RNF167

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.11132348
2negative regulation of cell killing (GO:0031342)5.10442764
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.10442764
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.06361161
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.06361161
6ribosomal small subunit assembly (GO:0000028)4.75773973
7DNA deamination (GO:0045006)4.74829693
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.61669756
9antigen processing and presentation of endogenous antigen (GO:0019883)4.61471218
10antigen processing and presentation via MHC class Ib (GO:0002475)4.30498774
11regulation of gamma-delta T cell differentiation (GO:0045586)4.13522230
12negative T cell selection (GO:0043383)4.09441658
13negative thymic T cell selection (GO:0045060)3.96443666
14regulation of gamma-delta T cell activation (GO:0046643)3.96069449
15detection of other organism (GO:0098543)3.92569222
16positive regulation by organism of defense response of other organism involved in symbiotic interact3.85890141
17modulation by symbiont of host immune response (GO:0052553)3.85890141
18positive regulation by symbiont of host defense response (GO:0052509)3.85890141
19modulation by symbiont of host defense response (GO:0052031)3.85890141
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.85890141
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.85890141
22signal complex assembly (GO:0007172)3.79715792
23neutrophil activation involved in immune response (GO:0002283)3.67698817
24interferon-gamma production (GO:0032609)3.64462045
25cellular response to interleukin-15 (GO:0071350)3.53075338
26positive thymic T cell selection (GO:0045059)3.49525388
27regulation of B cell receptor signaling pathway (GO:0050855)3.49428916
28response to peptidoglycan (GO:0032494)3.43192618
29regulation of isotype switching to IgG isotypes (GO:0048302)3.43051801
30regulation of B cell differentiation (GO:0045577)3.41928449
31response to interleukin-15 (GO:0070672)3.35234269
32negative regulation of erythrocyte differentiation (GO:0045647)3.34143677
33regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.32302331
34positive regulation of B cell differentiation (GO:0045579)3.30879580
35signal peptide processing (GO:0006465)3.30401888
36positive T cell selection (GO:0043368)3.28250598
37regulation of defense response to virus by virus (GO:0050690)3.27936418
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.25168642
39Arp2/3 complex-mediated actin nucleation (GO:0034314)3.21869293
40thymic T cell selection (GO:0045061)3.21464778
41T cell selection (GO:0045058)3.18723165
42response to type I interferon (GO:0034340)3.13370032
43leukocyte aggregation (GO:0070486)3.12464352
44cellular response to type I interferon (GO:0071357)3.12087298
45type I interferon signaling pathway (GO:0060337)3.12087298
46regulation of T cell receptor signaling pathway (GO:0050856)3.12080147
47negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.10404063
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.08933666
49negative regulation of leukocyte mediated immunity (GO:0002704)3.08366255
50positive regulation of granulocyte differentiation (GO:0030854)3.07280412
51negative regulation of glycoprotein biosynthetic process (GO:0010561)3.06955991
52B cell receptor signaling pathway (GO:0050853)3.05626546
53NIK/NF-kappaB signaling (GO:0038061)3.04964728
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.00264740
55detection of external biotic stimulus (GO:0098581)2.96388727
56positive regulation of Cdc42 GTPase activity (GO:0043089)2.95699635
57endosome to melanosome transport (GO:0035646)2.94954213
58endosome to pigment granule transport (GO:0043485)2.94954213
59respiratory burst (GO:0045730)2.94776616
60regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.94293567
61macrophage activation involved in immune response (GO:0002281)2.94235033
62modulation by virus of host process (GO:0019054)2.93579038
63antigen receptor-mediated signaling pathway (GO:0050851)2.90683409
64maturation of SSU-rRNA (GO:0030490)2.88560836
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.87850032
663-UTR-mediated mRNA stabilization (GO:0070935)2.87314323
67pentose-phosphate shunt (GO:0006098)2.87179297
68rRNA modification (GO:0000154)2.87123246
69cellular response to interferon-beta (GO:0035458)2.85682885
70T cell receptor signaling pathway (GO:0050852)2.82972094
71regulation of response to interferon-gamma (GO:0060330)2.82090090
72T cell migration (GO:0072678)2.81424705
73regulation of interferon-beta biosynthetic process (GO:0045357)2.81248885
74regulation of leukocyte degranulation (GO:0043300)2.78949197
75modulation by symbiont of host cellular process (GO:0044068)2.78609041
76L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.77748063
77negative regulation of innate immune response (GO:0045824)2.77454822
78rRNA methylation (GO:0031167)2.77220790
79Golgi transport vesicle coating (GO:0048200)2.74334420
80COPI coating of Golgi vesicle (GO:0048205)2.74334420
81regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.73350829
82regulation of natural killer cell mediated immunity (GO:0002715)2.73350829
83regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.73296484
84negative regulation of phagocytosis (GO:0050765)2.72257395
85regulation of superoxide anion generation (GO:0032928)2.71835559
86sequestering of actin monomers (GO:0042989)2.71028012
87negative regulation of stress fiber assembly (GO:0051497)2.70326019
88response to interferon-beta (GO:0035456)2.70199657
89regulation of myeloid leukocyte mediated immunity (GO:0002886)2.70021456
90response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.67654909
91response to host immune response (GO:0052572)2.67654909
92regulation of mast cell degranulation (GO:0043304)2.65706156
93tRNA methylation (GO:0030488)2.64434615
94SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.63943495
95negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.63915433
96neutrophil activation (GO:0042119)2.61536242
97T cell homeostasis (GO:0043029)2.61532039
98regulation of alpha-beta T cell proliferation (GO:0046640)2.60119360
99positive regulation of T cell mediated cytotoxicity (GO:0001916)2.60064815
100granulocyte activation (GO:0036230)2.59564161
101response to host (GO:0075136)2.58477587
102response to host defenses (GO:0052200)2.58477587
103response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.58477587
104immunoglobulin mediated immune response (GO:0016064)2.58291521
105positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.57508899
106regulation of T-helper 2 cell differentiation (GO:0045628)2.57026827
107mast cell activation (GO:0045576)2.56295501
108respiratory chain complex IV assembly (GO:0008535)2.55818040
109cellular response to interleukin-4 (GO:0071353)2.55799327
110pinocytosis (GO:0006907)2.55614787
111regulation of type I interferon-mediated signaling pathway (GO:0060338)2.55377031
112detection of biotic stimulus (GO:0009595)2.54903808
113regulation of regulatory T cell differentiation (GO:0045589)2.54327700
114cotranslational protein targeting to membrane (GO:0006613)2.53707917
115viral transcription (GO:0019083)2.53422609
116NADH metabolic process (GO:0006734)2.52874319
117ribosomal small subunit biogenesis (GO:0042274)2.52102556
118response to muramyl dipeptide (GO:0032495)2.52048849
119regulation of tolerance induction (GO:0002643)2.51917543
120detection of bacterium (GO:0016045)2.51613096
121metallo-sulfur cluster assembly (GO:0031163)2.51500076
122iron-sulfur cluster assembly (GO:0016226)2.51500076
123apoptotic process involved in morphogenesis (GO:0060561)2.50025693
124telomere maintenance via semi-conservative replication (GO:0032201)2.49796054
125protein targeting to ER (GO:0045047)2.49645560
126cellular response to zinc ion (GO:0071294)2.48477784
127lipopolysaccharide-mediated signaling pathway (GO:0031663)2.47667616
128GDP-mannose metabolic process (GO:0019673)2.47612978
129regulation of T cell tolerance induction (GO:0002664)2.47055825
130proteasome assembly (GO:0043248)2.46387452
131regulation of necrotic cell death (GO:0010939)2.45782616
132negative regulation of T cell mediated immunity (GO:0002710)2.45686826
133megakaryocyte development (GO:0035855)2.45402842
134lymphocyte homeostasis (GO:0002260)2.44903343
135regulation of necroptotic process (GO:0060544)2.44676980
136germinal center formation (GO:0002467)2.44659679
137RNA methylation (GO:0001510)2.44218367
138termination of RNA polymerase III transcription (GO:0006386)2.43454161
139transcription elongation from RNA polymerase III promoter (GO:0006385)2.43454161
140amino acid salvage (GO:0043102)2.43371083
141L-methionine salvage (GO:0071267)2.43371083
142L-methionine biosynthetic process (GO:0071265)2.43371083
143B cell mediated immunity (GO:0019724)2.42905478
144lymph node development (GO:0048535)2.42695957
145negative regulation of interleukin-12 production (GO:0032695)2.42486689
146protein localization to endoplasmic reticulum (GO:0070972)2.42412085
147mannose metabolic process (GO:0006013)2.42080127
148NADPH regeneration (GO:0006740)2.41558183
149protein localization to endosome (GO:0036010)2.41322113
150defense response to protozoan (GO:0042832)2.40314542
151deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.39636354
152mature B cell differentiation involved in immune response (GO:0002313)2.38696928
153interferon-gamma-mediated signaling pathway (GO:0060333)2.37406263
154leukocyte homeostasis (GO:0001776)2.37329572
155translational termination (GO:0006415)2.35982442
156RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.34492239
157chaperone mediated protein folding requiring cofactor (GO:0051085)2.34246436
158establishment of protein localization to endoplasmic reticulum (GO:0072599)2.34117460
159antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.33574001
160platelet dense granule organization (GO:0060155)2.33371315
161regulation of histone H3-K27 methylation (GO:0061085)2.32786543
162tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.32230984
163RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.32230984
164regulation of interleukin-12 biosynthetic process (GO:0045075)2.31603844
165regulation of T cell mediated cytotoxicity (GO:0001914)2.31481838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.50776691
2IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.31368262
3* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91186744
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90350397
5E2F7_22180533_ChIP-Seq_HELA_Human2.78254073
6SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.76645594
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72622243
8* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.70355955
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63047486
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.51932369
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51863760
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.50468778
13LXR_22292898_ChIP-Seq_THP-1_Human2.49324160
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48476803
15* GABP_17652178_ChIP-ChIP_JURKAT_Human2.48426610
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40534015
17* EST1_17652178_ChIP-ChIP_JURKAT_Human2.36601882
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.36110057
19SCL_19346495_ChIP-Seq_HPC-7_Human2.33168742
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29935165
21GATA1_22025678_ChIP-Seq_K562_Human2.26395123
22MYC_22102868_ChIP-Seq_BL_Human2.21376502
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21196756
24ELK3_25401928_ChIP-Seq_HUVEC_Human2.20953166
25CIITA_25753668_ChIP-Seq_RAJI_Human2.20160640
26ETS1_20019798_ChIP-Seq_JURKAT_Human2.19577247
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.16311187
28VDR_23849224_ChIP-Seq_CD4+_Human2.11961881
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.08493591
30KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06929290
31FOXP3_21729870_ChIP-Seq_TREG_Human2.06357511
32* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06288556
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03049365
34BP1_19119308_ChIP-ChIP_Hs578T_Human2.00759746
35SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.98616691
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.98379810
37TCF7_22412390_ChIP-Seq_EML_Mouse1.96350429
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.96309101
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.92774096
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.90510071
41KDM2B_26808549_Chip-Seq_DND41_Human1.90151399
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.89965384
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.89095617
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87271932
45RACK7_27058665_Chip-Seq_MCF-7_Human1.87003785
46VDR_24763502_ChIP-Seq_THP-1_Human1.86892497
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85406438
48* SPI1_23547873_ChIP-Seq_NB4_Human1.83147828
49* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82634490
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.82227438
51* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.82068269
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78340116
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76366479
54MYB_26560356_Chip-Seq_TH2_Human1.76072723
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72190135
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71282025
57P68_20966046_ChIP-Seq_HELA_Human1.66142730
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65812691
59* MAF_26560356_Chip-Seq_TH1_Human1.65618122
60* MYB_26560356_Chip-Seq_TH1_Human1.65479718
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.65157323
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64184471
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62615285
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60611303
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59596539
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.58158155
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58101328
68XRN2_22483619_ChIP-Seq_HELA_Human1.57336333
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56796578
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55831767
71VDR_21846776_ChIP-Seq_THP-1_Human1.54643107
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52160104
73GABP_19822575_ChIP-Seq_HepG2_Human1.52080891
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.51073316
75* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51018212
76TP63_17297297_ChIP-ChIP_HaCaT_Human1.49562519
77RUNX_20019798_ChIP-Seq_JUKART_Human1.49193064
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.48844286
79* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.48612434
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.47927147
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46492838
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46097377
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45583071
84E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44998602
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.43705060
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.42955562
87* UTX_26944678_Chip-Seq_JUKART_Human1.42643301
88BCOR_27268052_Chip-Seq_Bcells_Human1.42392441
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39823313
90NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39127024
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35882361
92DCP1A_22483619_ChIP-Seq_HELA_Human1.35372864
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34797143
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34152958
95PU.1_20513432_ChIP-Seq_Bcells_Mouse1.34016732
96SMC4_20622854_ChIP-Seq_HELA_Human1.32979191
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32919177
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31315232
99STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.30955723
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30751399
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30059240
102ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.28849072
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28247271
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26628628
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25178053
106MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24508339
107SPI1_23127762_ChIP-Seq_K562_Human1.24125417
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23986552
109NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23342612
110MAF_26560356_Chip-Seq_TH2_Human1.22091649
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21660953
112MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21105884
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20178448
114EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19958961
115KDM2B_26808549_Chip-Seq_JURKAT_Human1.19213300
116STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18755445
117NCOR1_26117541_ChIP-Seq_K562_Human1.18335034
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17946281
119PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17127359
120NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17005498
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16849575
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16145132
123KDM2B_26808549_Chip-Seq_K562_Human1.13409435
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12024141
125CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11743423
126EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11739498
127KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11482898
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11283645
129* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10762007
130GATA3_27048872_Chip-Seq_THYMUS_Human1.10062831
131CTCF_26484167_Chip-Seq_Bcells_Mouse1.09826153
132CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08980359
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08907878
134* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08321812
135CREB1_26743006_Chip-Seq_LNCaP_Human1.08307305
136SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08163996
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07944431
138MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07876626
139E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06767614
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06703115
141YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05921389
142* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05807390
143SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05679965
144SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05584826
145PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05290379
146ZNF263_19887448_ChIP-Seq_K562_Human1.05257382
147RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04944145
148NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04522870
149MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04192038
150CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04054527
151* GATA1_19941827_ChIP-Seq_MEL_Mouse1.02085427
152BCL6_27268052_Chip-Seq_Bcells_Human0.99936801
153TTF2_22483619_ChIP-Seq_HELA_Human0.99843385
154* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98623337
155GATA3_26560356_Chip-Seq_TH2_Human0.98159721
156KDM5A_27292631_Chip-Seq_BREAST_Human0.97526384
157IRF8_27001747_Chip-Seq_BMDM_Mouse0.96578299
158TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95893290
159ELK1_19687146_ChIP-ChIP_HELA_Human0.95471841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.95795484
2MP0003763_abnormal_thymus_physiology3.93156428
3MP0001835_abnormal_antigen_presentation3.63967527
4MP0003303_peritoneal_inflammation3.07959940
5MP0000685_abnormal_immune_system3.05203002
6MP0005451_abnormal_body_composition3.04742971
7MP0009785_altered_susceptibility_to2.64950434
8MP0001800_abnormal_humoral_immune2.63408814
9MP0001790_abnormal_immune_system2.43485674
10MP0005387_immune_system_phenotype2.43485674
11MP0002398_abnormal_bone_marrow2.40559169
12MP0003183_abnormal_peptide_metabolism2.35143549
13MP0002396_abnormal_hematopoietic_system2.33941174
14MP0002420_abnormal_adaptive_immunity2.33434674
15MP0001819_abnormal_immune_cell2.29390509
16MP0002723_abnormal_immune_serum2.28010803
17MP0002166_altered_tumor_susceptibility2.21978662
18MP0003693_abnormal_embryo_hatching2.21114947
19MP0002452_abnormal_antigen_presenting2.13111001
20MP0005025_abnormal_response_to2.13000416
21MP0005075_abnormal_melanosome_morpholog2.12356707
22MP0000716_abnormal_immune_system2.08405811
23MP0005000_abnormal_immune_tolerance2.08141537
24MP0002132_abnormal_respiratory_system2.07923884
25MP0000689_abnormal_spleen_morphology2.05450664
26MP0002722_abnormal_immune_system2.00651582
27MP0003300_gastrointestinal_ulcer1.99824299
28MP0009333_abnormal_splenocyte_physiolog1.97192145
29MP0001873_stomach_inflammation1.95156446
30MP0002148_abnormal_hypersensitivity_rea1.89018477
31MP0003705_abnormal_hypodermis_morpholog1.84491333
32MP0003191_abnormal_cellular_cholesterol1.83789185
33MP0002429_abnormal_blood_cell1.82760428
34MP0002405_respiratory_system_inflammati1.80144845
35MP0003724_increased_susceptibility_to1.79800842
36MP0000703_abnormal_thymus_morphology1.75446265
37MP0009278_abnormal_bone_marrow1.74433483
38MP0010155_abnormal_intestine_physiology1.73950313
39MP0002419_abnormal_innate_immunity1.71141334
40MP0001853_heart_inflammation1.69911745
41MP0005464_abnormal_platelet_physiology1.69543419
42MP0003866_abnormal_defecation1.65459492
43MP0008058_abnormal_DNA_repair1.64678030
44MP0003436_decreased_susceptibility_to1.62985778
45MP0002006_tumorigenesis1.60347589
46MP0005310_abnormal_salivary_gland1.56319668
47MP0004147_increased_porphyrin_level1.55635561
48MP0004858_abnormal_nervous_system1.54440002
49MP0001845_abnormal_inflammatory_respons1.50892437
50MP0004185_abnormal_adipocyte_glucose1.50592409
51MP0003656_abnormal_erythrocyte_physiolo1.49969711
52MP0002796_impaired_skin_barrier1.49905662
53MP0005397_hematopoietic_system_phenotyp1.47376684
54MP0001545_abnormal_hematopoietic_system1.47376684
55MP0004947_skin_inflammation1.46893409
56MP0004808_abnormal_hematopoietic_stem1.44897360
57MP0001849_ear_inflammation1.41619842
58MP0003075_altered_response_to1.40207046
59MP0001764_abnormal_homeostasis1.36551331
60MP0008007_abnormal_cellular_replicative1.35342665
61MP0003453_abnormal_keratinocyte_physiol1.34966639
62MP0003077_abnormal_cell_cycle1.33089679
63MP0006082_CNS_inflammation1.32436034
64MP0009840_abnormal_foam_cell1.29386000
65MP0008469_abnormal_protein_level1.29096663
66MP0004510_myositis1.28785739
67MP0001986_abnormal_taste_sensitivity1.27502741
68MP0002009_preneoplasia1.27180917
69MP0005174_abnormal_tail_pigmentation1.23801777
70MP0001851_eye_inflammation1.21662865
71MP0000490_abnormal_crypts_of1.21476740
72MP0003786_premature_aging1.19921310
73MP0001348_abnormal_lacrimal_gland1.17771809
74MP0010094_abnormal_chromosome_stability1.16712178
75MP0003566_abnormal_cell_adhesion1.16039034
76MP0005076_abnormal_cell_differentiation1.16014681
77MP0005365_abnormal_bile_salt1.15670172
78MP0003329_amyloid_beta_deposits1.14543427
79MP0006036_abnormal_mitochondrial_physio1.12258892
80MP0005666_abnormal_adipose_tissue1.12046412
81MP0008057_abnormal_DNA_replication1.11987680
82MP0002095_abnormal_skin_pigmentation1.09606120
83MP0009765_abnormal_xenobiotic_induced1.09570748
84MP0005166_decreased_susceptibility_to1.08183087
85MP0005501_abnormal_skin_physiology1.05963637
86MP0000465_gastrointestinal_hemorrhage1.05114995
87MP0003172_abnormal_lysosome_physiology1.03332410
88MP0003186_abnormal_redox_activity1.02960803
89MP0004381_abnormal_hair_follicle1.01719913
90MP0002019_abnormal_tumor_incidence1.01458319
91MP0002998_abnormal_bone_remodeling1.00032825
92MP0003448_altered_tumor_morphology0.99660583
93MP0008260_abnormal_autophagy0.98311250
94MP0004957_abnormal_blastocyst_morpholog0.97469848
95MP0002877_abnormal_melanocyte_morpholog0.97315781
96MP0002693_abnormal_pancreas_physiology0.96475299
97MP0006292_abnormal_olfactory_placode0.95441967
98MP0008874_decreased_physiological_sensi0.93387475
99MP0005058_abnormal_lysosome_morphology0.91946438
100MP0002876_abnormal_thyroid_physiology0.88876721
101MP0005375_adipose_tissue_phenotype0.88455818
102MP0000604_amyloidosis0.87617410
103MP0002933_joint_inflammation0.87174199
104MP0009643_abnormal_urine_homeostasis0.86808790
105MP0003828_pulmonary_edema0.86652901
106MP0003111_abnormal_nucleus_morphology0.86242883
107MP0000609_abnormal_liver_physiology0.86144183
108MP0000678_abnormal_parathyroid_gland0.86040105
109MP0000858_altered_metastatic_potential0.82470446
110MP0005083_abnormal_biliary_tract0.81720467
111MP0000015_abnormal_ear_pigmentation0.81441935
112MP0005409_darkened_coat_color0.81276222
113MP0005636_abnormal_mineral_homeostasis0.81200040
114MP0004264_abnormal_extraembryonic_tissu0.80878183
115MP0005379_endocrine/exocrine_gland_phen0.78700188
116MP0003943_abnormal_hepatobiliary_system0.77600196
117MP0006054_spinal_hemorrhage0.77484374
118MP0008004_abnormal_stomach_pH0.75932321
119MP0003806_abnormal_nucleotide_metabolis0.75881367
120MP0000313_abnormal_cell_death0.74808691
121MP0009931_abnormal_skin_appearance0.74519646
122MP0010234_abnormal_vibrissa_follicle0.74186795
123MP0009697_abnormal_copulation0.73717383
124MP0003091_abnormal_cell_migration0.72280414
125MP0009763_increased_sensitivity_to0.72170813
126MP0008995_early_reproductive_senescence0.71803056
127MP0001666_abnormal_nutrient_absorption0.70746967
128MP0005390_skeleton_phenotype0.70717598
129MP0005330_cardiomyopathy0.70063239
130MP0002136_abnormal_kidney_physiology0.68668875
131MP0000681_abnormal_thyroid_gland0.68323259
132MP0004233_abnormal_muscle_weight0.68218445
133MP0000343_altered_response_to0.68175251
134MP0000003_abnormal_adipose_tissue0.67118688
135MP0002638_abnormal_pupillary_reflex0.66305929
136MP0008877_abnormal_DNA_methylation0.66242403
137MP0005621_abnormal_cell_physiology0.66121076
138MP0005584_abnormal_enzyme/coenzyme_acti0.66096567
139MP0001533_abnormal_skeleton_physiology0.63676142
140MP0008875_abnormal_xenobiotic_pharmacok0.63372865
141MP0004782_abnormal_surfactant_physiolog0.62717077

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)4.28948100
2Abnormality of macrophages (HP:0004311)3.95893222
3Recurrent bronchitis (HP:0002837)3.87336992
4IgG deficiency (HP:0004315)3.72693219
5Panhypogammaglobulinemia (HP:0003139)3.71991077
6Chronic otitis media (HP:0000389)3.70760167
7Abnormality of T cell number (HP:0011839)3.68191685
8T lymphocytopenia (HP:0005403)3.64239593
9Aplastic anemia (HP:0001915)3.43606772
10Abnormality of T cells (HP:0002843)3.40438625
11Agammaglobulinemia (HP:0004432)3.35821370
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.32578005
13Elevated erythrocyte sedimentation rate (HP:0003565)3.29524450
14Severe combined immunodeficiency (HP:0004430)3.27022382
15Myositis (HP:0100614)3.18416817
16Obstructive lung disease (HP:0006536)3.18131966
17Chronic obstructive pulmonary disease (HP:0006510)3.18131966
18Recurrent viral infections (HP:0004429)3.14578630
19Abnormality of T cell physiology (HP:0011840)3.11675726
20Thrombocytosis (HP:0001894)3.06694389
21Recurrent fungal infections (HP:0002841)3.05260916
22Combined immunodeficiency (HP:0005387)3.03657505
23Hypoplasia of the thymus (HP:0000778)2.96709660
24Recurrent gram-negative bacterial infections (HP:0005420)2.95277417
25Recurrent cutaneous fungal infections (HP:0011370)2.91298150
26Chronic mucocutaneous candidiasis (HP:0002728)2.91298150
27Type I transferrin isoform profile (HP:0003642)2.91054146
28Abnormality of B cell number (HP:0010975)2.85959991
29B lymphocytopenia (HP:0010976)2.85959991
30Purpura (HP:0000979)2.85201064
31Lymphopenia (HP:0001888)2.82335924
32Increased IgM level (HP:0003496)2.78983285
33Bronchitis (HP:0012387)2.78008215
34Cellulitis (HP:0100658)2.77093622
35Nasal polyposis (HP:0100582)2.76924960
36Recurrent sinusitis (HP:0011108)2.75933497
37Abnormality of cells of the lymphoid lineage (HP:0012140)2.75803847
38Recurrent abscess formation (HP:0002722)2.74765951
39Centrally nucleated skeletal muscle fibers (HP:0003687)2.72419769
40Gastrointestinal infarctions (HP:0005244)2.71201499
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.70710116
42Chronic diarrhea (HP:0002028)2.67037833
43Urticaria (HP:0001025)2.66639989
44Abnormality of the nasal mucosa (HP:0000433)2.65955646
45Abnormality of eosinophils (HP:0001879)2.62759632
46Thyroiditis (HP:0100646)2.62684454
47Pustule (HP:0200039)2.60104534
48Mediastinal lymphadenopathy (HP:0100721)2.57805923
49Recurrent bacterial skin infections (HP:0005406)2.53592406
50Granulocytopenia (HP:0001913)2.52367737
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.48570831
52Abnormal protein N-linked glycosylation (HP:0012347)2.48570831
53Abnormal protein glycosylation (HP:0012346)2.48570831
54Abnormal glycosylation (HP:0012345)2.48570831
55Distal lower limb muscle weakness (HP:0009053)2.46471738
56Ragged-red muscle fibers (HP:0003200)2.45894090
57Meningitis (HP:0001287)2.44146784
58Abnormal number of erythroid precursors (HP:0012131)2.44009246
59Generalized aminoaciduria (HP:0002909)2.43499152
60Vertebral compression fractures (HP:0002953)2.38168185
613-Methylglutaconic aciduria (HP:0003535)2.36876792
62Hemorrhage of the eye (HP:0011885)2.36418148
63Stomatitis (HP:0010280)2.35902562
64Reticulocytopenia (HP:0001896)2.35833396
65Eosinophilia (HP:0001880)2.34612363
66Gingivitis (HP:0000230)2.33014577
67Prolonged bleeding time (HP:0003010)2.32197880
68Recurrent skin infections (HP:0001581)2.30950862
69Myopathic facies (HP:0002058)2.29780182
70Lymphoma (HP:0002665)2.28882152
71Chest pain (HP:0100749)2.26274772
7211 pairs of ribs (HP:0000878)2.25205984
73Eczematoid dermatitis (HP:0000976)2.25040168
74Slow saccadic eye movements (HP:0000514)2.24753084
75Abnormal gallbladder physiology (HP:0012438)2.22936510
76Cholecystitis (HP:0001082)2.22936510
77Autoimmune thrombocytopenia (HP:0001973)2.22235962
78Increased serum ferritin (HP:0003281)2.21580987
79Petechiae (HP:0000967)2.21368930
80Abnormality of cells of the erythroid lineage (HP:0012130)2.20971791
81Dry hair (HP:0011359)2.20143395
82Hepatic necrosis (HP:0002605)2.19921985
83Neutropenia (HP:0001875)2.19324800
84Polygenic inheritance (HP:0010982)2.19322661
85Increased cerebral lipofuscin (HP:0011813)2.19209719
86Pancytopenia (HP:0001876)2.18350963
87Reduced antithrombin III activity (HP:0001976)2.18331845
88Colitis (HP:0002583)2.16010917
89Hypoproteinemia (HP:0003075)2.15182174
90Gastrointestinal stroma tumor (HP:0100723)2.14408742
91Gastrointestinal inflammation (HP:0004386)2.11974834
92Encephalitis (HP:0002383)2.11922143
93Loss of speech (HP:0002371)2.11682483
94Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.11488571
95Hypertensive crisis (HP:0100735)2.10814088
96Joint swelling (HP:0001386)2.09870799
97Autoimmune hemolytic anemia (HP:0001890)2.09529585
98Abnormality of the fingertips (HP:0001211)2.07762139
99Distal lower limb amyotrophy (HP:0008944)2.07459108
100Hepatosplenomegaly (HP:0001433)2.05760536
101Inflammation of the large intestine (HP:0002037)2.04737837
102Retrobulbar optic neuritis (HP:0100654)2.04495783
103Optic neuritis (HP:0100653)2.04495783
104Hepatocellular necrosis (HP:0001404)2.03158601
105IgA deficiency (HP:0002720)2.03089406
106Gastrointestinal dysmotility (HP:0002579)2.03014443
107Supranuclear gaze palsy (HP:0000605)2.02896938
108Acute hepatic failure (HP:0006554)2.02654366
109Microvesicular hepatic steatosis (HP:0001414)2.01455244
110Segmental peripheral demyelination/remyelination (HP:0003481)2.00552693
111Abnormality of glycolipid metabolism (HP:0010969)1.99067384
112Abnormality of liposaccharide metabolism (HP:0010968)1.99067384
113Abnormality of glycosphingolipid metabolism (HP:0004343)1.99067384
114Hypochromic anemia (HP:0001931)1.99035187
115Amaurosis fugax (HP:0100576)1.99021083
116Exercise-induced myalgia (HP:0003738)1.98378790
117Hypergammaglobulinemia (HP:0010702)1.98328039
118Renal cortical cysts (HP:0000803)1.97926653
119Abnormality of skeletal muscle fiber size (HP:0012084)1.97208217
120Abnormality of fatty-acid metabolism (HP:0004359)1.96734681
121Increased IgE level (HP:0003212)1.96669470
122Gingival bleeding (HP:0000225)1.95340049
123Spontaneous hematomas (HP:0007420)1.95132195
124Epistaxis (HP:0000421)1.94901459
125Systemic lupus erythematosus (HP:0002725)1.94116384
126Hypercortisolism (HP:0001578)1.92726561
127Orchitis (HP:0100796)1.92641017
128Growth hormone excess (HP:0000845)1.92335699
129Skin rash (HP:0000988)1.91334394
130Leukocytosis (HP:0001974)1.91081479
131Hypertriglyceridemia (HP:0002155)1.91032820
132Increased connective tissue (HP:0009025)1.90722620
133Chronic sinusitis (HP:0011109)1.90498174
134Abnormality of the anterior horn cell (HP:0006802)1.90136120
135Degeneration of anterior horn cells (HP:0002398)1.90136120
136Birth length less than 3rd percentile (HP:0003561)1.89887630
137Poikiloderma (HP:0001029)1.89764780
138Vasculitis (HP:0002633)1.87830616
139Increased neuronal autofluorescent lipopigment (HP:0002074)1.87778524
140Skin ulcer (HP:0200042)1.87683421
141Cheilitis (HP:0100825)1.85409282
142Neuronal loss in central nervous system (HP:0002529)1.83763768
143Arterial thrombosis (HP:0004420)1.82348855
144Dysostosis multiplex (HP:0000943)1.82296144
145Progressive muscle weakness (HP:0003323)1.81711594
146Microcytic anemia (HP:0001935)1.81292978
147Keratoconjunctivitis sicca (HP:0001097)1.80888298
148Increased variability in muscle fiber diameter (HP:0003557)1.80318681
149Basal cell carcinoma (HP:0002671)1.79690677
150Amyloidosis (HP:0011034)1.79452023
151Metaphyseal cupping (HP:0003021)1.79202694
152Abnormal platelet volume (HP:0011876)1.78628776
153Abnormality of iron homeostasis (HP:0011031)1.78528424
154Interstitial pulmonary disease (HP:0006530)1.78351439
155Erythema (HP:0010783)1.77709721
156Type 2 muscle fiber atrophy (HP:0003554)1.76178240
157Easy fatigability (HP:0003388)1.76172856
158Myelodysplasia (HP:0002863)1.76153940
159Achilles tendon contracture (HP:0001771)1.75049383
160Emphysema (HP:0002097)1.74211519
161Malnutrition (HP:0004395)1.73263956
162Fatigue (HP:0012378)1.72543320
163Long palpebral fissure (HP:0000637)1.69558886
164Deep venous thrombosis (HP:0002625)1.69155603
165Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68783401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.21933353
2TXK3.88904144
3TRIB33.49125951
4PRPF4B3.40471803
5SMG13.32697964
6STK162.80037727
7TYK22.60981541
8IKBKE2.50962683
9KIT2.33331771
10ZAP702.22671262
11MAP3K112.15047422
12TESK12.11175619
13TEC2.07620393
14JAK31.97550131
15IRAK41.95439829
16BTK1.93988232
17SRPK11.93293909
18BCKDK1.90972274
19FGFR41.88921158
20FLT31.86702821
21TAOK11.86328941
22MAP3K121.85435585
23TAOK21.83519689
24SIK11.80383869
25ICK1.80289080
26ADRBK21.76566594
27RIPK11.72244850
28BUB11.71169801
29KDR1.69589772
30TBK11.66209297
31CDK121.60082639
32MAP3K31.55936124
33PASK1.53029880
34ITK1.52886393
35EPHB11.51010433
36SYK1.49721027
37SIK31.49104512
38GRK61.45389404
39VRK11.45027338
40MAPK151.44218186
41BRSK21.42549813
42FES1.41852248
43TGFBR21.40100340
44MAP3K141.38314658
45WEE11.37595622
46NLK1.33448736
47CDK191.32875776
48TNK21.31911386
49MAPKAPK31.30678906
50EIF2AK11.28842518
51CSF1R1.25064612
52ACVR1B1.24073180
53IKBKB1.24041845
54ARAF1.20639508
55ERN11.20630341
56JAK11.20141985
57MAP3K11.19383486
58TSSK61.19356656
59KSR21.18001079
60IRAK31.17034832
61LCK1.15938675
62VRK21.15295962
63MAP3K101.14787926
64DAPK11.07986843
65PTK61.07795658
66CCNB11.07546350
67LRRK21.06982234
68PDPK11.04907977
69MST41.02546192
70LYN0.97484688
71MAP2K60.96570994
72MAPK110.92055972
73PRKD20.90461385
74FGFR30.90325258
75MAP3K130.86416370
76PRKD30.85824221
77RPS6KB20.85784333
78BMX0.85299304
79BLK0.84906420
80MARK20.84592612
81STK100.84465612
82EIF2AK30.84070222
83TTN0.83707510
84EEF2K0.82933506
85SIK20.81664302
86DYRK30.81545901
87TESK20.80189059
88BRSK10.80130321
89PIM10.79114353
90YES10.78820421
91TLK10.77555693
92PAK40.76668515
93HIPK20.76548560
94PDK10.74261605
95PINK10.73437916
96MAP3K80.72955345
97TIE10.72421055
98MYLK0.71061495
99CDC42BPA0.70533757
100CSK0.70526901
101CDK40.68122606
102INSRR0.67826567
103IRAK20.67393346
104MAPK70.67193172
105CHUK0.66680947
106PLK40.64647545
107PKN20.64496689
108MARK30.64298286
109FGR0.63079943
110TGFBR10.62835753
111AKT30.61854984
112SCYL20.59451235
113MAP2K20.58899504
114GRK10.57942576
115CDK80.56475105
116STK240.55974803
117PRKG20.55359859
118ATR0.54990762
119EPHA20.54336094
120HCK0.54112436
121BRD40.53727953
122STK380.50623003
123NEK20.50141744
124CLK10.47638150
125MAPK120.46133310
126EIF2AK20.46030270
127BRAF0.45194203
128MAPKAPK20.44365870
129JAK20.43750285
130MAP2K30.43260786
131MUSK0.42829896
132PDK20.42697271
133RIPK40.42204529
134RPS6KA20.42060101
135RPS6KA40.41930915
136FYN0.41777212
137RPS6KA60.41478806
138CDK60.40880218
139PIM20.40546252
140PAK10.39557007
141TAOK30.39417326
142CAMKK20.37563402
143ZAK0.37394526
144MTOR0.36663235
145CAMKK10.36626500
146DYRK1B0.36115294
147CDK70.35664827
148MATK0.35641967
149NME20.35556268
150BMPR20.34501121
151DAPK30.34469155
152ALK0.33907620
153PRKCD0.33001495
154RPS6KC10.32667115
155RPS6KL10.32667115
156LIMK10.31972035
157MAP3K50.31197709

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.77211701
2DNA replication_Homo sapiens_hsa030302.81883890
3Ribosome_Homo sapiens_hsa030102.72955598
4Mismatch repair_Homo sapiens_hsa034302.51964463
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.49416440
6Protein export_Homo sapiens_hsa030602.47547144
7RNA polymerase_Homo sapiens_hsa030202.43924919
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.37524229
9Antigen processing and presentation_Homo sapiens_hsa046122.25743398
10Proteasome_Homo sapiens_hsa030502.23581384
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.18222157
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.18211101
13Base excision repair_Homo sapiens_hsa034102.13302376
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.08583775
15Folate biosynthesis_Homo sapiens_hsa007901.90005612
16Homologous recombination_Homo sapiens_hsa034401.89086162
17Pyrimidine metabolism_Homo sapiens_hsa002401.85953241
18Spliceosome_Homo sapiens_hsa030401.77580054
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74302550
20Herpes simplex infection_Homo sapiens_hsa051681.74034929
21Hematopoietic cell lineage_Homo sapiens_hsa046401.70249959
22Non-homologous end-joining_Homo sapiens_hsa034501.66674623
23Measles_Homo sapiens_hsa051621.66016949
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58168242
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.51729261
26Allograft rejection_Homo sapiens_hsa053301.51471964
27Viral myocarditis_Homo sapiens_hsa054161.51238540
28Regulation of autophagy_Homo sapiens_hsa041401.50988781
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48622274
30Non-small cell lung cancer_Homo sapiens_hsa052231.46874460
31Nucleotide excision repair_Homo sapiens_hsa034201.45450814
32Chronic myeloid leukemia_Homo sapiens_hsa052201.44248909
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42542821
34Tuberculosis_Homo sapiens_hsa051521.41722218
35RNA degradation_Homo sapiens_hsa030181.38830476
36T cell receptor signaling pathway_Homo sapiens_hsa046601.37572023
37Other glycan degradation_Homo sapiens_hsa005111.35476312
38VEGF signaling pathway_Homo sapiens_hsa043701.35443228
39Pentose phosphate pathway_Homo sapiens_hsa000301.30560116
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27449983
41B cell receptor signaling pathway_Homo sapiens_hsa046621.26227442
42Basal transcription factors_Homo sapiens_hsa030221.24347577
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23907857
44Caffeine metabolism_Homo sapiens_hsa002321.23825537
45Pancreatic cancer_Homo sapiens_hsa052121.22753613
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.21943818
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21338700
48ABC transporters_Homo sapiens_hsa020101.19224460
49Fanconi anemia pathway_Homo sapiens_hsa034601.18028488
50Endocytosis_Homo sapiens_hsa041441.17419928
51Sulfur relay system_Homo sapiens_hsa041221.17052354
52Prion diseases_Homo sapiens_hsa050201.16340334
53Biosynthesis of amino acids_Homo sapiens_hsa012301.13177701
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12049598
55Hepatitis C_Homo sapiens_hsa051601.10796205
56Leishmaniasis_Homo sapiens_hsa051401.10776841
57Central carbon metabolism in cancer_Homo sapiens_hsa052301.10363223
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10025681
59Malaria_Homo sapiens_hsa051441.08809839
60Salmonella infection_Homo sapiens_hsa051321.08514209
61Jak-STAT signaling pathway_Homo sapiens_hsa046301.04612640
62Purine metabolism_Homo sapiens_hsa002301.04597480
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04015209
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02831029
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02653939
66Selenocompound metabolism_Homo sapiens_hsa004501.02437768
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01031091
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99398463
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97925735
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94466498
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.93508947
72Legionellosis_Homo sapiens_hsa051340.92335916
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91955710
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87736162
75Phenylalanine metabolism_Homo sapiens_hsa003600.87705472
76Insulin signaling pathway_Homo sapiens_hsa049100.85244965
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83093485
78Viral carcinogenesis_Homo sapiens_hsa052030.82788565
79RNA transport_Homo sapiens_hsa030130.82646653
80Autoimmune thyroid disease_Homo sapiens_hsa053200.82026533
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.82011124
82Thyroid cancer_Homo sapiens_hsa052160.81647985
83TNF signaling pathway_Homo sapiens_hsa046680.81605766
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81402140
85Carbon metabolism_Homo sapiens_hsa012000.81365303
86Bladder cancer_Homo sapiens_hsa052190.81153396
87Epstein-Barr virus infection_Homo sapiens_hsa051690.81087498
88Phagosome_Homo sapiens_hsa041450.80889038
89Graft-versus-host disease_Homo sapiens_hsa053320.79264083
90One carbon pool by folate_Homo sapiens_hsa006700.78407067
91Endometrial cancer_Homo sapiens_hsa052130.78291918
92N-Glycan biosynthesis_Homo sapiens_hsa005100.77961385
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77929183
94Influenza A_Homo sapiens_hsa051640.76837540
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74854102
96Peroxisome_Homo sapiens_hsa041460.73542920
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.73293025
98p53 signaling pathway_Homo sapiens_hsa041150.72154647
99Platelet activation_Homo sapiens_hsa046110.71790018
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71225961
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.70102756
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67505197
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67432550
104Renal cell carcinoma_Homo sapiens_hsa052110.67430132
105Vibrio cholerae infection_Homo sapiens_hsa051100.65352013
106Pertussis_Homo sapiens_hsa051330.63858793
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63743304
108mTOR signaling pathway_Homo sapiens_hsa041500.63102359
109Cell cycle_Homo sapiens_hsa041100.62466049
110Fructose and mannose metabolism_Homo sapiens_hsa000510.61962071
111Osteoclast differentiation_Homo sapiens_hsa043800.61549007
112Notch signaling pathway_Homo sapiens_hsa043300.60874253
113Insulin resistance_Homo sapiens_hsa049310.60401523
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60224946
115Amoebiasis_Homo sapiens_hsa051460.57709894
116Choline metabolism in cancer_Homo sapiens_hsa052310.56764838
117Inositol phosphate metabolism_Homo sapiens_hsa005620.56383415
118ErbB signaling pathway_Homo sapiens_hsa040120.56223451
119African trypanosomiasis_Homo sapiens_hsa051430.56014704
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55380476
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55266913
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.54649684
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.50957441
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50758978
125HIF-1 signaling pathway_Homo sapiens_hsa040660.50709554
126Glioma_Homo sapiens_hsa052140.50568301
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50055122
128GnRH signaling pathway_Homo sapiens_hsa049120.49389670
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.48592083
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48222712
131Hepatitis B_Homo sapiens_hsa051610.47574315
132Lysosome_Homo sapiens_hsa041420.46721563
133Galactose metabolism_Homo sapiens_hsa000520.46146708
134Vitamin B6 metabolism_Homo sapiens_hsa007500.45966767
135Staphylococcus aureus infection_Homo sapiens_hsa051500.45032500
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.43992780
137Acute myeloid leukemia_Homo sapiens_hsa052210.43606676
138Type I diabetes mellitus_Homo sapiens_hsa049400.42436764
139Fatty acid degradation_Homo sapiens_hsa000710.40798213
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39694269
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39444048
142mRNA surveillance pathway_Homo sapiens_hsa030150.38942854
143Fatty acid elongation_Homo sapiens_hsa000620.38861574
144Vitamin digestion and absorption_Homo sapiens_hsa049770.36928340
145Metabolic pathways_Homo sapiens_hsa011000.36034434
146Circadian rhythm_Homo sapiens_hsa047100.35264389
147Sphingolipid metabolism_Homo sapiens_hsa006000.34666375
148Propanoate metabolism_Homo sapiens_hsa006400.33620739
149Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33568940
150HTLV-I infection_Homo sapiens_hsa051660.33147530
151Arachidonic acid metabolism_Homo sapiens_hsa005900.33041576
152Chemokine signaling pathway_Homo sapiens_hsa040620.31821918
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.31164929
154Toxoplasmosis_Homo sapiens_hsa051450.29883118
155Apoptosis_Homo sapiens_hsa042100.29774296
156Shigellosis_Homo sapiens_hsa051310.29212167

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »