RNF17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is similar to a mouse gene that encodes a testis-specific protein containing a RING finger domain. Alternatively spliced transcript variants encoding different isoforms have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)8.77814028
2gonadal mesoderm development (GO:0007506)8.53370979
3positive regulation of meiosis (GO:0045836)7.69257289
4positive regulation of meiotic cell cycle (GO:0051446)7.20493823
5synaptonemal complex assembly (GO:0007130)7.11104414
6male meiosis (GO:0007140)6.91810263
7synaptonemal complex organization (GO:0070193)6.79418736
8DNA methylation involved in gamete generation (GO:0043046)6.62328450
9acrosome reaction (GO:0007340)6.53010384
10nuclear pore complex assembly (GO:0051292)5.90768642
11cilium or flagellum-dependent cell motility (GO:0001539)5.79546873
12nuclear pore organization (GO:0006999)5.69501984
13chromosome organization involved in meiosis (GO:0070192)5.50064205
14chromosome condensation (GO:0030261)5.41674909
15meiotic nuclear division (GO:0007126)5.22902429
16regulation of meiosis (GO:0040020)5.22201330
17fusion of sperm to egg plasma membrane (GO:0007342)5.20503233
18centriole replication (GO:0007099)5.16016481
19DNA packaging (GO:0006323)5.13928537
20sperm-egg recognition (GO:0035036)5.00990817
21regulation of meiosis I (GO:0060631)4.96835664
22binding of sperm to zona pellucida (GO:0007339)4.90353050
23histone H3-K9 demethylation (GO:0033169)4.88441975
24oocyte development (GO:0048599)4.83115655
25regulation of meiotic cell cycle (GO:0051445)4.79346723
26acrosome assembly (GO:0001675)4.70307105
27male meiosis I (GO:0007141)4.69720310
28female gamete generation (GO:0007292)4.68236255
29pore complex assembly (GO:0046931)4.51553396
30cell-cell recognition (GO:0009988)4.44488376
31DNA replication-dependent nucleosome assembly (GO:0006335)4.40675516
32DNA replication-dependent nucleosome organization (GO:0034723)4.40675516
33multicellular organism reproduction (GO:0032504)4.35718843
34fertilization (GO:0009566)4.34896994
35gene silencing by RNA (GO:0031047)4.32908067
36spermatogenesis (GO:0007283)4.32763693
37male gamete generation (GO:0048232)4.32570733
38oogenesis (GO:0048477)4.29894171
39microtubule polymerization or depolymerization (GO:0031109)4.29324340
40regulation of centriole replication (GO:0046599)4.26211439
41cell wall macromolecule catabolic process (GO:0016998)4.23029885
42cell wall macromolecule metabolic process (GO:0044036)4.23029885
43* germ cell development (GO:0007281)4.21176460
44gamete generation (GO:0007276)4.15317707
45meiotic cell cycle process (GO:1903046)4.14848789
46protein K6-linked ubiquitination (GO:0085020)4.13214404
47DNA synthesis involved in DNA repair (GO:0000731)4.12266543
48meiosis I (GO:0007127)4.11893000
49sperm motility (GO:0030317)4.11206697
50histone exchange (GO:0043486)4.05974882
51centriole assembly (GO:0098534)4.05562116
52regulation of acrosome reaction (GO:0060046)4.05398313
53regulation of female gonad development (GO:2000194)4.04390448
54mitotic metaphase plate congression (GO:0007080)4.04053267
55* spermatid development (GO:0007286)4.03688604
56meiotic chromosome segregation (GO:0045132)4.02543677
57axonemal dynein complex assembly (GO:0070286)4.00761469
58attachment of spindle microtubules to kinetochore (GO:0008608)3.95836277
59DNA alkylation (GO:0006305)3.92188854
60DNA methylation (GO:0006306)3.92188854
61regulation of histone H3-K9 methylation (GO:0051570)3.91234564
62chromatin remodeling at centromere (GO:0031055)3.91219782
63oocyte maturation (GO:0001556)3.85217935
64microtubule severing (GO:0051013)3.84512526
65mitotic nuclear envelope disassembly (GO:0007077)3.84439375
66spermatid nucleus differentiation (GO:0007289)3.81342038
67microtubule depolymerization (GO:0007019)3.80894463
68plasma membrane fusion (GO:0045026)3.80276386
69sperm capacitation (GO:0048240)3.77708779
70kinetochore organization (GO:0051383)3.76453196
71metaphase plate congression (GO:0051310)3.76155147
72calcium ion-dependent exocytosis (GO:0017156)3.71785462
73reciprocal DNA recombination (GO:0035825)3.70159108
74reciprocal meiotic recombination (GO:0007131)3.70159108
75positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.68722591
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.68722591
77positive regulation of mitotic sister chromatid separation (GO:1901970)3.68722591
78DNA replication initiation (GO:0006270)3.67954826
79protein localization to kinetochore (GO:0034501)3.65360186
80DNA replication checkpoint (GO:0000076)3.64464078
81* cellular process involved in reproduction in multicellular organism (GO:0022412)3.63202299
82protein localization to chromosome, centromeric region (GO:0071459)3.61790447
83nuclear envelope disassembly (GO:0051081)3.60841319
84membrane disassembly (GO:0030397)3.60841319
85epithelial cilium movement (GO:0003351)3.60573730
86mitotic chromosome condensation (GO:0007076)3.59258688
87single strand break repair (GO:0000012)3.59245858
88regulation of posttranscriptional gene silencing (GO:0060147)3.58153074
89regulation of gene silencing by miRNA (GO:0060964)3.58153074
90regulation of gene silencing by RNA (GO:0060966)3.58153074
91meiotic cell cycle (GO:0051321)3.57522840
92negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.57283770
93monoubiquitinated protein deubiquitination (GO:0035520)3.56243766
94epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.54730632
95CENP-A containing nucleosome assembly (GO:0034080)3.53642699
96positive regulation of chromosome segregation (GO:0051984)3.52441395
97DNA replication-independent nucleosome organization (GO:0034724)3.47235810
98DNA replication-independent nucleosome assembly (GO:0006336)3.47235810
99heterochromatin organization (GO:0070828)3.45166741
100synapsis (GO:0007129)3.44692868
101sister chromatid cohesion (GO:0007062)3.44105658
102regulation of chromosome segregation (GO:0051983)3.43711110
103single fertilization (GO:0007338)3.42464945
104regulation of centrosome cycle (GO:0046605)3.40185495
105mitotic sister chromatid segregation (GO:0000070)3.40108166
106mitotic sister chromatid cohesion (GO:0007064)3.37716029
107reproduction (GO:0000003)3.37211877
108somatic diversification of immune receptors via somatic mutation (GO:0002566)3.34728102
109somatic hypermutation of immunoglobulin genes (GO:0016446)3.34728102
110motile cilium assembly (GO:0044458)3.34592516
111kinetochore assembly (GO:0051382)3.33910163
112negative regulation of gene silencing (GO:0060969)3.33159355
113protein targeting to Golgi (GO:0000042)3.32969470
114DNA methylation or demethylation (GO:0044728)3.32433970
115chaperone-mediated protein complex assembly (GO:0051131)3.32338435
116nucleus organization (GO:0006997)3.26513806
117multicellular organismal reproductive process (GO:0048609)3.25585758
118regulation of helicase activity (GO:0051095)3.25291873
119gene silencing (GO:0016458)3.24561771
120regulation of DNA methylation (GO:0044030)3.24004974
121regulation of mitotic metaphase/anaphase transition (GO:0030071)3.23801430
122negative regulation of chromosome segregation (GO:0051985)3.22014316
123resolution of meiotic recombination intermediates (GO:0000712)3.21867670
124establishment of protein localization to Golgi (GO:0072600)3.21347364
125regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.19382596
126establishment of chromosome localization (GO:0051303)3.19302013
127regulation of spindle organization (GO:0090224)3.18479083
128regulation of mitotic sister chromatid separation (GO:0010965)3.17173816
129regulation of mitotic sister chromatid segregation (GO:0033047)3.17173816
130regulation of sister chromatid segregation (GO:0033045)3.17173816
131negative regulation of meiosis (GO:0045835)3.17109984
132negative regulation of mitotic sister chromatid separation (GO:2000816)3.16299984
133negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16299984
134negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16299984
135negative regulation of sister chromatid segregation (GO:0033046)3.16299984
136protein polyglutamylation (GO:0018095)3.15998858
137purine nucleobase biosynthetic process (GO:0009113)3.14853909
138nucleobase biosynthetic process (GO:0046112)3.14540294
139negative regulation of histone methylation (GO:0031061)3.14273006
140positive regulation of translational initiation (GO:0045948)3.11944516
141N-terminal protein amino acid acetylation (GO:0006474)3.10676663
142regulation of DNA endoreduplication (GO:0032875)3.10415115
143seminiferous tubule development (GO:0072520)3.08547548
144negative regulation of meiotic cell cycle (GO:0051447)3.02213957
145retrograde transport, vesicle recycling within Golgi (GO:0000301)3.01984624
146regulation of retinoic acid receptor signaling pathway (GO:0048385)2.98257615
147sex differentiation (GO:0007548)2.93553423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.81738341
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.24959654
3EZH2_22144423_ChIP-Seq_EOC_Human5.85488626
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.40314966
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.85719130
6IGF1R_20145208_ChIP-Seq_DFB_Human3.56671690
7* MYC_18555785_ChIP-Seq_MESCs_Mouse3.43718008
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.33228523
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10686681
10ZNF274_21170338_ChIP-Seq_K562_Hela3.03284486
11SALL1_21062744_ChIP-ChIP_HESCs_Human3.00883951
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.68740841
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64784455
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40548276
15MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23612499
16VDR_22108803_ChIP-Seq_LS180_Human2.22093151
17AR_21909140_ChIP-Seq_LNCAP_Human2.20656507
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.19520023
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.19520023
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.19520023
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.18140349
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.12532484
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12223562
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11124642
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09862317
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09408082
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05341870
28* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.03884084
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96952849
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.95996814
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86750573
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84706508
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79208302
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.78646470
35* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.76606115
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.76575617
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73687860
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.72655279
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71840603
40XRN2_22483619_ChIP-Seq_HELA_Human1.68943521
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66349034
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65987582
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65110494
44VDR_23849224_ChIP-Seq_CD4+_Human1.62361412
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.61665623
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60336074
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57700899
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56137657
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56137657
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56112653
51TAF15_26573619_Chip-Seq_HEK293_Human1.55995593
52CBP_20019798_ChIP-Seq_JUKART_Human1.55756438
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55756438
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53500034
55SMAD4_21741376_ChIP-Seq_EPCs_Human1.52373947
56GBX2_23144817_ChIP-Seq_PC3_Human1.51757403
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51228734
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51161571
59FUS_26573619_Chip-Seq_HEK293_Human1.50692425
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50184500
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.48507851
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48184401
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47700616
64STAT3_23295773_ChIP-Seq_U87_Human1.47425945
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44005430
66* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43641680
67FOXP3_21729870_ChIP-Seq_TREG_Human1.40151401
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37456907
69ER_23166858_ChIP-Seq_MCF-7_Human1.36824413
70RUNX2_22187159_ChIP-Seq_PCA_Human1.36701292
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35947717
72AR_25329375_ChIP-Seq_VCAP_Human1.35731638
73GATA3_26560356_Chip-Seq_TH1_Human1.35624207
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33328752
75RNF2_27304074_Chip-Seq_NSC_Mouse1.33004088
76DCP1A_22483619_ChIP-Seq_HELA_Human1.31849005
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31082821
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31011767
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30796315
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29674759
81GABP_19822575_ChIP-Seq_HepG2_Human1.29151834
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29005118
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28498731
84TTF2_22483619_ChIP-Seq_HELA_Human1.28286941
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.28102320
86TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22969118
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22796059
88TCF4_23295773_ChIP-Seq_U87_Human1.22762319
89BCAT_22108803_ChIP-Seq_LS180_Human1.21131996
90* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19247438
91KAP1_22055183_ChIP-Seq_ESCs_Mouse1.18503911
92KDM5A_27292631_Chip-Seq_BREAST_Human1.18301954
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18034977
94FOXH1_21741376_ChIP-Seq_EPCs_Human1.17157512
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16504586
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.16419518
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15201287
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15079452
99YY1_21170310_ChIP-Seq_MESCs_Mouse1.14593471
100SMAD4_21799915_ChIP-Seq_A2780_Human1.13465473
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13286352
102* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12531306
103RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11878402
104ETV1_20927104_ChIP-Seq_GIST48_Human1.11459847
105HOXB7_26014856_ChIP-Seq_BT474_Human1.11121705
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10060016
107IRF1_19129219_ChIP-ChIP_H3396_Human1.08775664
108NANOG_19829295_ChIP-Seq_ESCs_Human1.08119204
109SOX2_19829295_ChIP-Seq_ESCs_Human1.08119204
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07751732
111CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07157113
112NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.06855126
113* P300_19829295_ChIP-Seq_ESCs_Human1.06150544
114TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05599669
115NANOG_21062744_ChIP-ChIP_HESCs_Human1.03937979
116RBPJ_21746931_ChIP-Seq_IB4_Human1.03869956
117NANOG_20526341_ChIP-Seq_ESCs_Human1.03735851
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03642243
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03437050
120HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03047019
121RAC3_21632823_ChIP-Seq_H3396_Human1.03010657
122FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02268066
123ELK1_19687146_ChIP-ChIP_HELA_Human1.02260601
124MYC_19829295_ChIP-Seq_ESCs_Human1.01769213
125* FOXA1_25329375_ChIP-Seq_VCAP_Human0.99654033
126* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99654033
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99056275
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98639282
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98398345
130* SMAD3_21741376_ChIP-Seq_EPCs_Human0.97438369
131BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97212237
132EWS_26573619_Chip-Seq_HEK293_Human0.97134743
133FLI1_27457419_Chip-Seq_LIVER_Mouse0.95855744
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.94162562
135SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93994294
136NFYB_21822215_ChIP-Seq_K562_Human0.93954954
137WDR5_24793694_ChIP-Seq_LNCAP_Human0.93631594
138* GATA3_21878914_ChIP-Seq_MCF-7_Human0.93562319
139CBX2_22325352_ChIP-Seq_293T-Rex_Human0.92758612
140SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92644056
141TP53_22573176_ChIP-Seq_HFKS_Human0.91614707
142E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90992166
143ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90913809
144TCF4_22108803_ChIP-Seq_LS180_Human0.90671915
145ERA_21632823_ChIP-Seq_H3396_Human0.90585050
146SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89817768
147KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88880471
148HNFA_21074721_ChIP-Seq_CACO-2_Human0.88654300
149RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88271451
150E2F1_17053090_ChIP-ChIP_MCF-7_Human0.88216515
151NANOG_18692474_ChIP-Seq_MESCs_Mouse0.88112088
152ERG_20517297_ChIP-Seq_VCAP_Human0.87527316
153ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.86644001
154CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86611475
155CBP_21632823_ChIP-Seq_H3396_Human0.86268839
156CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86195462
157POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.86168248
158PHF8_20622853_ChIP-Seq_HELA_Human0.85578831
159PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.84954928
160CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84776179
161EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84229253
162MYC_18940864_ChIP-ChIP_HL60_Human0.82684556
163NANOG_18692474_ChIP-Seq_MEFs_Mouse0.82357411
164SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82309219
165POU5F1_16518401_ChIP-PET_MESCs_Mouse0.82302740
166SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80678040
167NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.79932740
168SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.79701363
169KAP1_27257070_Chip-Seq_ESCs_Mouse0.79497974
170PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78771473
171TP63_19390658_ChIP-ChIP_HaCaT_Human0.77973613
172ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76813389
173NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.76290837
174HOXB4_20404135_ChIP-ChIP_EML_Mouse0.75869603
175CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75772382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.63260800
2MP0008057_abnormal_DNA_replication5.06957183
3MP0005410_abnormal_fertilization5.04693603
4MP0010094_abnormal_chromosome_stability4.69359466
5MP0003693_abnormal_embryo_hatching4.09138210
6MP0003111_abnormal_nucleus_morphology3.81937934
7MP0008058_abnormal_DNA_repair3.80235709
8* MP0001929_abnormal_gametogenesis3.62059158
9MP0004957_abnormal_blastocyst_morpholog3.60825083
10MP0010368_abnormal_lymphatic_system3.56027744
11MP0003077_abnormal_cell_cycle3.43866607
12* MP0002210_abnormal_sex_determination3.42976026
13* MP0003698_abnormal_male_reproductive3.16587898
14* MP0001145_abnormal_male_reproductive2.86673985
15MP0003786_premature_aging2.71462717
16MP0002653_abnormal_ependyma_morphology2.57236595
17MP0008007_abnormal_cellular_replicative2.55889299
18* MP0000653_abnormal_sex_gland2.54984758
19MP0003183_abnormal_peptide_metabolism2.39187432
20MP0003123_paternal_imprinting2.19638378
21MP0001730_embryonic_growth_arrest2.18343356
22MP0008995_early_reproductive_senescence2.12017907
23MP0010307_abnormal_tumor_latency2.08583346
24MP0008932_abnormal_embryonic_tissue2.07150545
25* MP0002161_abnormal_fertility/fecundity1.93718342
26MP0000350_abnormal_cell_proliferation1.91913739
27MP0003718_maternal_effect1.78549746
28MP0000678_abnormal_parathyroid_gland1.75762479
29MP0003787_abnormal_imprinting1.66206663
30MP0005174_abnormal_tail_pigmentation1.63266959
31MP0010352_gastrointestinal_tract_polyps1.63093527
32MP0002084_abnormal_developmental_patter1.58224030
33MP0005380_embryogenesis_phenotype1.57354109
34MP0001672_abnormal_embryogenesis/_devel1.57354109
35MP0003121_genomic_imprinting1.55508762
36MP0003806_abnormal_nucleotide_metabolis1.53316412
37MP0001697_abnormal_embryo_size1.52894380
38MP0002160_abnormal_reproductive_system1.51536349
39MP0002085_abnormal_embryonic_tissue1.49763796
40MP0010030_abnormal_orbit_morphology1.37889648
41MP0005623_abnormal_meninges_morphology1.37722804
42MP0008789_abnormal_olfactory_epithelium1.32114997
43MP0003984_embryonic_growth_retardation1.29951886
44MP0004147_increased_porphyrin_level1.28813060
45MP0001188_hyperpigmentation1.28416076
46MP0002080_prenatal_lethality1.28247366
47MP0004197_abnormal_fetal_growth/weight/1.28115593
48MP0003890_abnormal_embryonic-extraembry1.28102448
49MP0002086_abnormal_extraembryonic_tissu1.27215605
50MP0001119_abnormal_female_reproductive1.26614632
51MP0000313_abnormal_cell_death1.26222369
52MP0002088_abnormal_embryonic_growth/wei1.25954777
53MP0001879_abnormal_lymphatic_vessel1.21745992
54MP0001293_anophthalmia1.20029526
55MP0004133_heterotaxia1.15268814
56MP0005389_reproductive_system_phenotype1.11106438
57MP0009697_abnormal_copulation1.06208318
58MP0005451_abnormal_body_composition1.05087047
59MP0005499_abnormal_olfactory_system1.04860649
60MP0005394_taste/olfaction_phenotype1.04860649
61MP0003699_abnormal_female_reproductive1.04149723
62MP0003941_abnormal_skin_development1.01494844
63MP0002019_abnormal_tumor_incidence0.98190144
64MP0001666_abnormal_nutrient_absorption0.96435179
65MP0004808_abnormal_hematopoietic_stem0.95870666
66MP0001545_abnormal_hematopoietic_system0.91304839
67MP0005397_hematopoietic_system_phenotyp0.91304839
68MP0000569_abnormal_digit_pigmentation0.91041917
69MP0005076_abnormal_cell_differentiation0.90288614
70MP0003879_abnormal_hair_cell0.89693169
71MP0003119_abnormal_digestive_system0.88689586
72MP0002234_abnormal_pharynx_morphology0.84392082
73MP0003315_abnormal_perineum_morphology0.81496360
74MP0003646_muscle_fatigue0.78766207
75MP0003136_yellow_coat_color0.78362774
76MP0002138_abnormal_hepatobiliary_system0.76565150
77MP0005379_endocrine/exocrine_gland_phen0.76039292
78MP0005647_abnormal_sex_gland0.74363476
79MP0005551_abnormal_eye_electrophysiolog0.73802623
80MP0002396_abnormal_hematopoietic_system0.73242691
81MP0005266_abnormal_metabolism0.70932266
82MP0003937_abnormal_limbs/digits/tail_de0.70637560
83MP0000358_abnormal_cell_content/0.69636271
84MP0003936_abnormal_reproductive_system0.67602280
85MP0009703_decreased_birth_body0.66936072
86MP0000490_abnormal_crypts_of0.66836271
87MP0003567_abnormal_fetal_cardiomyocyte0.66792315
88MP0006292_abnormal_olfactory_placode0.66740691
89MP0000566_synostosis0.65289752
90MP0001486_abnormal_startle_reflex0.64979365
91MP0001963_abnormal_hearing_physiology0.64880958
92MP0005395_other_phenotype0.64863255
93MP0003861_abnormal_nervous_system0.64378612
94MP0003878_abnormal_ear_physiology0.64013984
95MP0005377_hearing/vestibular/ear_phenot0.64013984
96MP0002735_abnormal_chemical_nociception0.63146916
97MP0005384_cellular_phenotype0.62655678
98MP0001915_intracranial_hemorrhage0.61606309
99MP0003950_abnormal_plasma_membrane0.61457276
100MP0001919_abnormal_reproductive_system0.60198051
101MP0005409_darkened_coat_color0.60074244
102MP0004215_abnormal_myocardial_fiber0.59831132
103MP0000462_abnormal_digestive_system0.59038926
104MP0005621_abnormal_cell_physiology0.56972181
105MP0009672_abnormal_birth_weight0.56915494
106MP0000432_abnormal_head_morphology0.56280378
107MP0003943_abnormal_hepatobiliary_system0.54439832
108MP0000049_abnormal_middle_ear0.54026009
109MP0001177_atelectasis0.53102200
110MP0000631_abnormal_neuroendocrine_gland0.52866222
111MP0002139_abnormal_hepatobiliary_system0.52099232
112MP0004233_abnormal_muscle_weight0.52056827
113MP0002092_abnormal_eye_morphology0.51572449
114MP0005423_abnormal_somatic_nervous0.51202839
115MP0003186_abnormal_redox_activity0.50965745
116MP0000427_abnormal_hair_cycle0.50891799
117MP0002229_neurodegeneration0.50767275
118MP0002127_abnormal_cardiovascular_syste0.50577505
119MP0009278_abnormal_bone_marrow0.49474352
120MP0003959_abnormal_lean_body0.49150613
121MP0002095_abnormal_skin_pigmentation0.48948368
122MP0003566_abnormal_cell_adhesion0.48702360
123MP0000516_abnormal_urinary_system0.48658283
124MP0005367_renal/urinary_system_phenotyp0.48658283
125MP0002272_abnormal_nervous_system0.48088567
126MP0002282_abnormal_trachea_morphology0.47954663
127MP0002928_abnormal_bile_duct0.46373851
128MP0008004_abnormal_stomach_pH0.46154935
129MP0004264_abnormal_extraembryonic_tissu0.46132599
130MP0004036_abnormal_muscle_relaxation0.46016036
131MP0001849_ear_inflammation0.45520125
132MP0001485_abnormal_pinna_reflex0.45217139
133MP0000015_abnormal_ear_pigmentation0.45194309
134MP0003935_abnormal_craniofacial_develop0.45076388
135MP0009053_abnormal_anal_canal0.44837832
136MP0002111_abnormal_tail_morphology0.44685809
137MP0000026_abnormal_inner_ear0.44364280
138MP0003283_abnormal_digestive_organ0.43701595
139MP0001286_abnormal_eye_development0.43582415
140MP0009115_abnormal_fat_cell0.42725933
141MP0001764_abnormal_homeostasis0.42176591
142MP0006072_abnormal_retinal_apoptosis0.41603824
143MP0002269_muscular_atrophy0.41027406
144MP0005023_abnormal_wound_healing0.40558588
145MP0000703_abnormal_thymus_morphology0.40310244
146MP0005670_abnormal_white_adipose0.40175075
147MP0004084_abnormal_cardiac_muscle0.40088792
148MP0002697_abnormal_eye_size0.39384792

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.58796884
2Absent/shortened dynein arms (HP:0200106)5.99593423
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.99593423
4Osteomalacia (HP:0002749)5.86606213
5Tubulointerstitial nephritis (HP:0001970)4.94880641
6Abnormal respiratory motile cilium physiology (HP:0012261)4.88685778
7Abnormal respiratory epithelium morphology (HP:0012253)4.33395700
8Abnormal respiratory motile cilium morphology (HP:0005938)4.33395700
9Abnormal spermatogenesis (HP:0008669)4.29470304
10Rhinitis (HP:0012384)4.26150513
11Chromsome breakage (HP:0040012)4.24143660
12Enlarged epiphyses (HP:0010580)4.00784683
13Delayed epiphyseal ossification (HP:0002663)3.99385459
14Supernumerary spleens (HP:0009799)3.98928579
15Birth length less than 3rd percentile (HP:0003561)3.96991784
16Chronic bronchitis (HP:0004469)3.94679636
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.92550371
18Abnormal ciliary motility (HP:0012262)3.92546146
19Azoospermia (HP:0000027)3.91117442
20Scotoma (HP:0000575)3.80520342
21Impulsivity (HP:0100710)3.70040899
22Abnormality of the costochondral junction (HP:0000919)3.69820582
23Abnormality of the lower motor neuron (HP:0002366)3.69753174
24Breast hypoplasia (HP:0003187)3.69716380
25Abnormality of the labia minora (HP:0012880)3.50734426
26Chronic hepatic failure (HP:0100626)3.46350716
27Ependymoma (HP:0002888)3.44702968
28Selective tooth agenesis (HP:0001592)3.42527193
2911 pairs of ribs (HP:0000878)3.35629058
30Degeneration of anterior horn cells (HP:0002398)3.26938940
31Abnormality of the anterior horn cell (HP:0006802)3.26938940
32Degeneration of the lateral corticospinal tracts (HP:0002314)3.26266152
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.26266152
34Infertility (HP:0000789)3.25165766
35Hypophosphatemic rickets (HP:0004912)3.22986756
36Abnormality of chromosome stability (HP:0003220)3.21327737
37Severe visual impairment (HP:0001141)3.19579490
38Horizontal nystagmus (HP:0000666)3.18257412
39Medulloblastoma (HP:0002885)3.14855382
40Abnormality of the corticospinal tract (HP:0002492)3.05938774
41Oligodactyly (hands) (HP:0001180)3.03641389
42Gonadotropin excess (HP:0000837)3.02089285
43Male infertility (HP:0003251)2.98892615
44Meckel diverticulum (HP:0002245)2.90634562
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.87562603
46Rickets (HP:0002748)2.85396714
47Thin bony cortex (HP:0002753)2.85365769
48Abnormal auditory evoked potentials (HP:0006958)2.80219063
49Short tibia (HP:0005736)2.79874778
50Abnormality of the ileum (HP:0001549)2.79835036
51Abnormality of the preputium (HP:0100587)2.78547890
52Metaphyseal irregularity (HP:0003025)2.77848882
53Truncal obesity (HP:0001956)2.77183937
54Agnosia (HP:0010524)2.77114014
55Nasal polyposis (HP:0100582)2.68660497
56Abnormality of the fovea (HP:0000493)2.65273460
57Neoplasm of the oral cavity (HP:0100649)2.64906698
58Nephronophthisis (HP:0000090)2.64460770
59Rhabdomyosarcoma (HP:0002859)2.64352279
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.63306019
61Absent radius (HP:0003974)2.62515188
62Carpal bone hypoplasia (HP:0001498)2.61452188
63Missing ribs (HP:0000921)2.60872665
64Amyotrophic lateral sclerosis (HP:0007354)2.56652075
65Aplasia/Hypoplasia of the earlobes (HP:0009906)2.56640394
66Abnormality of macular pigmentation (HP:0008002)2.51796927
67Sloping forehead (HP:0000340)2.51791175
68Abnormality of the astrocytes (HP:0100707)2.48037568
69Astrocytoma (HP:0009592)2.48037568
70Patellar aplasia (HP:0006443)2.46954777
71Gonadal dysgenesis (HP:0000133)2.46738058
72Absent forearm bone (HP:0003953)2.46631555
73Aplasia involving forearm bones (HP:0009822)2.46631555
74Duodenal stenosis (HP:0100867)2.46630195
75Small intestinal stenosis (HP:0012848)2.46630195
76Ectopic kidney (HP:0000086)2.46117819
77Absent thumb (HP:0009777)2.44959879
78Tubulointerstitial abnormality (HP:0001969)2.41539012
79Bronchiectasis (HP:0002110)2.40703536
80Colon cancer (HP:0003003)2.40040156
81Bony spicule pigmentary retinopathy (HP:0007737)2.39127403
82Nephroblastoma (Wilms tumor) (HP:0002667)2.38863468
83Facial cleft (HP:0002006)2.36822980
84Upper motor neuron abnormality (HP:0002127)2.34635634
85Abnormality of DNA repair (HP:0003254)2.34066227
86Abnormality of chromosome segregation (HP:0002916)2.32219354
87Anterior segment dysgenesis (HP:0007700)2.30436351
88Bronchitis (HP:0012387)2.27252960
89Attenuation of retinal blood vessels (HP:0007843)2.26926872
90Volvulus (HP:0002580)2.23405519
91Aplasia/Hypoplasia of the patella (HP:0006498)2.23191100
92Abnormality of abdominal situs (HP:0011620)2.22660588
93Abdominal situs inversus (HP:0003363)2.22660588
94Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.21777583
95Widely patent fontanelles and sutures (HP:0004492)2.18443408
96Facial hemangioma (HP:0000329)2.18317474
97Biliary tract neoplasm (HP:0100574)2.18272723
98Embryonal renal neoplasm (HP:0011794)2.17967019
99Shawl scrotum (HP:0000049)2.17922875
100Aplasia/hypoplasia of the humerus (HP:0006507)2.17335310
101Septate vagina (HP:0001153)2.17240785
102Hypergonadotropic hypogonadism (HP:0000815)2.17021452
103Myelodysplasia (HP:0002863)2.15758824
104Glioma (HP:0009733)2.13622672
105Microglossia (HP:0000171)2.13471245
106Median cleft lip (HP:0000161)2.09377335
107Duplicated collecting system (HP:0000081)2.08333974
108Hyperkalemia (HP:0002153)2.07968586
109Molar tooth sign on MRI (HP:0002419)2.07911079
110Abnormality of midbrain morphology (HP:0002418)2.07911079
111Cone-rod dystrophy (HP:0000548)2.07652017
112Spontaneous abortion (HP:0005268)2.06891140
113Abnormality of the nasal mucosa (HP:0000433)2.06666922
114Aplasia/Hypoplasia of the fovea (HP:0008060)2.05738018
115Hypoplasia of the fovea (HP:0007750)2.05738018
116Menstrual irregularities (HP:0000858)2.05659380
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03969705
118Generalized aminoaciduria (HP:0002909)2.03286092
119Abnormality of the duodenum (HP:0002246)2.02930848
120Short humerus (HP:0005792)2.02919392
121Tongue fasciculations (HP:0001308)2.02698920
122Abnormality of the carotid arteries (HP:0005344)2.01660161
123Atrophy/Degeneration involving motor neurons (HP:0007373)2.00736035
124Oligodactyly (HP:0012165)2.00281363
125Neoplasm of striated muscle (HP:0009728)1.98634751
126Papillary thyroid carcinoma (HP:0002895)1.96941399
127Heterotopia (HP:0002282)1.94625551
128Fibular hypoplasia (HP:0003038)1.92972331
129Increased nuchal translucency (HP:0010880)1.92805603
130Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.90979592
131Short ribs (HP:0000773)1.90657789
132Sandal gap (HP:0001852)1.90592288
133Abnormality of the renal medulla (HP:0100957)1.90164801
134Central scotoma (HP:0000603)1.89730429
135Aplasia/Hypoplasia of the sternum (HP:0006714)1.87211613
136Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86677458
137Reticulocytopenia (HP:0001896)1.85762696
138Resting tremor (HP:0002322)1.85699132
139Embryonal neoplasm (HP:0002898)1.84341503
140Capillary hemangiomas (HP:0005306)1.82992795
141Aplasia/Hypoplasia of the tongue (HP:0010295)1.81965822
142Bone marrow hypocellularity (HP:0005528)1.81270597
143Abnormal lung lobation (HP:0002101)1.80938355
144Basal cell carcinoma (HP:0002671)1.80268215
145Breast carcinoma (HP:0003002)1.79698888
146Hypoplasia of the radius (HP:0002984)1.79086557
147Horseshoe kidney (HP:0000085)1.78782150
148Proximal tubulopathy (HP:0000114)1.77954685
149Clubbing of toes (HP:0100760)1.77876657
150Impaired vibration sensation in the lower limbs (HP:0002166)1.77247555
151Short thumb (HP:0009778)1.76820514
152Amaurosis fugax (HP:0100576)1.76555336
153Subcapsular cataract (HP:0000523)1.76343965
154Muscle fibrillation (HP:0010546)1.76310940
155Intellectual disability, moderate (HP:0002342)1.76134754
156Retinal dysplasia (HP:0007973)1.75725735
157Lip pit (HP:0100267)1.74934939
158Abnormality of the renal collecting system (HP:0004742)1.69374942
159Leiomyosarcoma (HP:0100243)1.64090732
160Uterine leiomyosarcoma (HP:0002891)1.64090732

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.01860967
2PDK45.01860967
3CDC74.35361600
4WEE14.23094049
5CDK194.04249866
6PDK23.33215785
7NEK23.02820328
8BUB12.94435734
9TTK2.90884699
10ACVR1B2.71977713
11CDK122.71177700
12PNCK2.67131002
13PLK42.48582955
14KSR22.41657972
15NEK12.21659164
16PLK12.12275500
17STK392.07685317
18SRPK11.96083596
19MAP3K21.95337760
20EPHA21.93378814
21ATR1.86802452
22NTRK31.72351556
23PASK1.71923876
24CHEK21.71873269
25MAP3K91.64556754
26EIF2AK11.60176674
27STK38L1.58679482
28TSSK61.55988250
29CAMK1G1.55852180
30CHEK11.54679560
31MAP3K131.51710820
32BRSK21.50660299
33TESK11.40501160
34PLK31.39025862
35DYRK31.37371878
36RPS6KB21.34368046
37ARAF1.34013182
38AURKB1.31518469
39CDK71.30192638
40ATM1.27556569
41MST1R1.26846265
42TRIM281.24304348
43NEK91.17298777
44RAF11.16113595
45PLK21.15786585
46PRKD31.13929873
47CDK81.12995546
48ICK1.12646484
49CDK41.12485771
50BRD41.12264555
51KSR11.10501514
52STK161.10176499
53MKNK21.06235919
54INSRR1.05974791
55BRSK11.05592555
56STK30.98196306
57VRK10.97333743
58AKT30.95810595
59AURKA0.95734914
60ZAK0.95710268
61MATK0.95341067
62MKNK10.94833468
63CLK10.94776403
64STK40.93385319
65PIK3CG0.92471353
66BMPR1B0.91911964
67CDK20.91328029
68TLK10.80675167
69MAP3K80.80382527
70EIF2AK30.78387019
71EPHA40.76902047
72FLT30.76480977
73CDK10.74039751
74KIT0.72742799
75MELK0.72439872
76PBK0.71315073
77BRAF0.68744514
78PTK2B0.68593873
79CCNB10.67352630
80CDK60.66556807
81CSNK2A20.63060244
82TAOK30.61526168
83EEF2K0.59955855
84STK100.59288123
85CSNK1D0.58780105
86MAP3K10.58078312
87PINK10.56693227
88STK380.53451440
89MTOR0.52253672
90CSNK2A10.51638257
91NEK60.51626103
92PIM10.51449782
93WNK30.51338637
94ALK0.50899601
95TGFBR10.50790695
96MARK30.49162404
97PRKDC0.48782474
98DDR20.48635894
99PRKG10.48280804
100LATS20.45651405
101PAK40.44337562
102TYRO30.43955572
103CSNK1E0.41734555
104PAK10.41679497
105MAPKAPK30.41670781
106SCYL20.41397138
107OXSR10.38787609
108TESK20.37282426
109MET0.36030767
110MAPK140.35010716
111GSK3B0.34478069
112PRKCI0.34243188
113NME20.33392908
114WNK10.32870885
115LATS10.32372212
116MOS0.30871360
117SGK10.30298182
118MST40.29792833
119CAMK10.29447566
120PKN10.29416183
121RPS6KB10.29307030
122CDK30.28585450
123ERBB40.26589490
124MAP4K20.26034954
125MAPK10.25215078
126MAP3K40.24638133
127WNK40.24521674
128STK240.23925946
129PRKACB0.23726763
130MAP3K60.23651742
131CDK11A0.22525890
132RPS6KA10.21905121
133MAPK100.21171731
134PDK10.19571481
135MAP3K70.19140800
136AKT10.18812370
137RET0.17755548
138RPS6KA50.17559573
139MAPK80.16538977
140CDK90.16520965
141DYRK20.15352425
142EIF2AK20.14129113
143RPS6KA40.13811735

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.45758106
2Mismatch repair_Homo sapiens_hsa034304.35573109
3DNA replication_Homo sapiens_hsa030304.25178931
4RNA transport_Homo sapiens_hsa030133.66147694
5Basal transcription factors_Homo sapiens_hsa030223.56820394
6Homologous recombination_Homo sapiens_hsa034403.53146726
7Fanconi anemia pathway_Homo sapiens_hsa034603.50544110
8Cell cycle_Homo sapiens_hsa041103.05257313
9Spliceosome_Homo sapiens_hsa030402.98669225
10Nucleotide excision repair_Homo sapiens_hsa034202.88427239
11Non-homologous end-joining_Homo sapiens_hsa034502.66963952
12RNA polymerase_Homo sapiens_hsa030202.60447402
13Base excision repair_Homo sapiens_hsa034102.58765714
14One carbon pool by folate_Homo sapiens_hsa006702.52408115
15mRNA surveillance pathway_Homo sapiens_hsa030152.41224147
16Proteasome_Homo sapiens_hsa030502.29724627
17RNA degradation_Homo sapiens_hsa030182.21412968
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19791293
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.14944434
20Pyrimidine metabolism_Homo sapiens_hsa002401.97232379
21Olfactory transduction_Homo sapiens_hsa047401.94906579
22Oocyte meiosis_Homo sapiens_hsa041141.84589294
23Selenocompound metabolism_Homo sapiens_hsa004501.65436302
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61814670
25p53 signaling pathway_Homo sapiens_hsa041151.61503115
26Regulation of autophagy_Homo sapiens_hsa041401.59873077
27Vitamin B6 metabolism_Homo sapiens_hsa007501.55526567
28Ribosome_Homo sapiens_hsa030101.51133300
29Systemic lupus erythematosus_Homo sapiens_hsa053221.36142738
30Pentose phosphate pathway_Homo sapiens_hsa000301.34937465
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.34164955
32Purine metabolism_Homo sapiens_hsa002301.34130703
33ABC transporters_Homo sapiens_hsa020101.27487814
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19251424
35Circadian rhythm_Homo sapiens_hsa047101.19062295
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18579112
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13042311
38Biosynthesis of amino acids_Homo sapiens_hsa012301.11160884
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11097066
40Steroid biosynthesis_Homo sapiens_hsa001001.06592407
41Epstein-Barr virus infection_Homo sapiens_hsa051691.05710534
42Viral carcinogenesis_Homo sapiens_hsa052030.99532500
43Pyruvate metabolism_Homo sapiens_hsa006200.99070638
44Fatty acid elongation_Homo sapiens_hsa000620.96830977
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95874899
46Phototransduction_Homo sapiens_hsa047440.95555974
47Gap junction_Homo sapiens_hsa045400.86890734
48Antigen processing and presentation_Homo sapiens_hsa046120.84130160
49Ovarian steroidogenesis_Homo sapiens_hsa049130.82099353
50Dorso-ventral axis formation_Homo sapiens_hsa043200.81695229
51Huntingtons disease_Homo sapiens_hsa050160.79360775
52Fatty acid metabolism_Homo sapiens_hsa012120.77049107
53Caffeine metabolism_Homo sapiens_hsa002320.75877397
54Herpes simplex infection_Homo sapiens_hsa051680.74839075
55Linoleic acid metabolism_Homo sapiens_hsa005910.72408137
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70668630
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70213930
58Fatty acid degradation_Homo sapiens_hsa000710.65468878
59Carbon metabolism_Homo sapiens_hsa012000.64467856
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.63816999
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62635472
62HTLV-I infection_Homo sapiens_hsa051660.61903790
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61363636
64Type II diabetes mellitus_Homo sapiens_hsa049300.60331139
65Lysine degradation_Homo sapiens_hsa003100.59364050
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56890443
67MicroRNAs in cancer_Homo sapiens_hsa052060.54079995
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53743491
69TGF-beta signaling pathway_Homo sapiens_hsa043500.53146660
70Glucagon signaling pathway_Homo sapiens_hsa049220.52013156
71Nicotine addiction_Homo sapiens_hsa050330.51387903
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.49037407
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49010479
74Fructose and mannose metabolism_Homo sapiens_hsa000510.48737420
75Alcoholism_Homo sapiens_hsa050340.48362321
76Thyroid cancer_Homo sapiens_hsa052160.48228524
77N-Glycan biosynthesis_Homo sapiens_hsa005100.45840510
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45027440
79Glutathione metabolism_Homo sapiens_hsa004800.43135374
80Hippo signaling pathway_Homo sapiens_hsa043900.43038790
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43001952
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42656467
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.42347326
84Butanoate metabolism_Homo sapiens_hsa006500.39954046
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39673952
86Retinol metabolism_Homo sapiens_hsa008300.39577074
87Taste transduction_Homo sapiens_hsa047420.39023237
88Sulfur relay system_Homo sapiens_hsa041220.38503992
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37641464
90Synaptic vesicle cycle_Homo sapiens_hsa047210.37363298
91Propanoate metabolism_Homo sapiens_hsa006400.36352663
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34818458
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34232910
94ErbB signaling pathway_Homo sapiens_hsa040120.34070574
95Tight junction_Homo sapiens_hsa045300.33689315
96Endocytosis_Homo sapiens_hsa041440.33301006
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.32951276
98Fatty acid biosynthesis_Homo sapiens_hsa000610.32676070
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.32157652
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31738915
101Calcium signaling pathway_Homo sapiens_hsa040200.30071407
102Small cell lung cancer_Homo sapiens_hsa052220.29695636
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29197381
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.28752315
105Renin-angiotensin system_Homo sapiens_hsa046140.28670361
106Protein digestion and absorption_Homo sapiens_hsa049740.28469384
107Basal cell carcinoma_Homo sapiens_hsa052170.28024969
108Adherens junction_Homo sapiens_hsa045200.26670548
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24137375
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23685476
111Glycerolipid metabolism_Homo sapiens_hsa005610.23439908
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22452800
113Notch signaling pathway_Homo sapiens_hsa043300.22147637
114Hedgehog signaling pathway_Homo sapiens_hsa043400.21725765
115Bile secretion_Homo sapiens_hsa049760.21618627
116Arachidonic acid metabolism_Homo sapiens_hsa005900.21516820
117Legionellosis_Homo sapiens_hsa051340.20454006
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.20306626
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20286961
120Folate biosynthesis_Homo sapiens_hsa007900.20005267
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19728865
122Acute myeloid leukemia_Homo sapiens_hsa052210.18081867
123Metabolic pathways_Homo sapiens_hsa011000.17972184
124Morphine addiction_Homo sapiens_hsa050320.17001870
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15826080
126Long-term depression_Homo sapiens_hsa047300.15358261
127Choline metabolism in cancer_Homo sapiens_hsa052310.14462948
128Arginine and proline metabolism_Homo sapiens_hsa003300.14195842
129HIF-1 signaling pathway_Homo sapiens_hsa040660.13095133
130mTOR signaling pathway_Homo sapiens_hsa041500.12857283
131Pathways in cancer_Homo sapiens_hsa052000.12840159
132beta-Alanine metabolism_Homo sapiens_hsa004100.12301198
133Ether lipid metabolism_Homo sapiens_hsa005650.11432440
134Influenza A_Homo sapiens_hsa051640.11318098
135cAMP signaling pathway_Homo sapiens_hsa040240.10908865
136Wnt signaling pathway_Homo sapiens_hsa043100.10653164
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.08586770
138Colorectal cancer_Homo sapiens_hsa052100.05894997
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.05851399
140Prostate cancer_Homo sapiens_hsa052150.05243625
141Inositol phosphate metabolism_Homo sapiens_hsa005620.02510549
142FoxO signaling pathway_Homo sapiens_hsa040680.00098760
143Bacterial invasion of epithelial cells_Homo sapiens_hsa05100-0.0609038
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0510566
145Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630-0.0449977
146Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0394652
147Fat digestion and absorption_Homo sapiens_hsa04975-0.0315433
148AMPK signaling pathway_Homo sapiens_hsa04152-0.0127873

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