RNF175

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.36040201
2pyrimidine nucleobase catabolic process (GO:0006208)4.71420219
3regulation of synaptic vesicle exocytosis (GO:2000300)4.49009112
4positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.44860919
5positive regulation by symbiont of host defense response (GO:0052509)4.24098797
6modulation by symbiont of host defense response (GO:0052031)4.24098797
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.24098797
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.24098797
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.24098797
10modulation by symbiont of host immune response (GO:0052553)4.24098797
11locomotory exploration behavior (GO:0035641)4.09245061
12synaptic vesicle exocytosis (GO:0016079)4.04611267
13microglial cell activation (GO:0001774)4.01628661
14short-term memory (GO:0007614)3.90977211
15regulation of synaptic vesicle transport (GO:1902803)3.87714109
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.83846188
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.77678278
18detection of molecule of bacterial origin (GO:0032490)3.75155130
19exploration behavior (GO:0035640)3.73505386
20macrophage activation involved in immune response (GO:0002281)3.69900182
21cerebellar Purkinje cell differentiation (GO:0021702)3.65087461
22neutrophil mediated immunity (GO:0002446)3.64865987
23dendritic spine morphogenesis (GO:0060997)3.60279583
24neuron cell-cell adhesion (GO:0007158)3.48900397
25nucleobase catabolic process (GO:0046113)3.48812967
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.42776764
27postsynaptic membrane organization (GO:0001941)3.39832589
28protein localization to synapse (GO:0035418)3.30897957
29myeloid leukocyte mediated immunity (GO:0002444)3.27526849
30neuronal action potential propagation (GO:0019227)3.26128451
31regulation of short-term neuronal synaptic plasticity (GO:0048172)3.22497269
32negative regulation of interleukin-12 production (GO:0032695)3.20123256
33response to peptidoglycan (GO:0032494)3.17625352
34establishment of mitochondrion localization (GO:0051654)3.16273134
35presynaptic membrane assembly (GO:0097105)3.15913988
36synaptic vesicle endocytosis (GO:0048488)3.14884555
37transmission of nerve impulse (GO:0019226)3.13088316
38vocalization behavior (GO:0071625)3.12276388
39synaptic vesicle docking involved in exocytosis (GO:0016081)3.10609762
40axonal fasciculation (GO:0007413)3.09367160
41cerebral cortex radially oriented cell migration (GO:0021799)3.07491699
42positive regulation of neurotransmitter transport (GO:0051590)3.03908101
43neurotransmitter-gated ion channel clustering (GO:0072578)3.03604264
44presynaptic membrane organization (GO:0097090)3.03067300
45leukocyte migration involved in inflammatory response (GO:0002523)3.00729966
46regulation of synapse structural plasticity (GO:0051823)2.99183851
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.98546411
48neuron-neuron synaptic transmission (GO:0007270)2.98343797
49synaptic transmission, glutamatergic (GO:0035249)2.98315743
50neutrophil activation involved in immune response (GO:0002283)2.98110657
51behavioral response to cocaine (GO:0048148)2.97509619
52adult walking behavior (GO:0007628)2.97051846
53regulation of voltage-gated calcium channel activity (GO:1901385)2.97008505
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.95127140
55negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.94806596
56negative regulation of cell killing (GO:0031342)2.94806596
57neurofilament cytoskeleton organization (GO:0060052)2.94303944
58neuron fate determination (GO:0048664)2.94023219
59macrophage activation (GO:0042116)2.92695365
60glutamate secretion (GO:0014047)2.92006173
61negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.89620959
62neuron recognition (GO:0008038)2.88214912
63respiratory burst (GO:0045730)2.87040134
64regulation of excitatory postsynaptic membrane potential (GO:0060079)2.83515997
65positive regulation of neurotransmitter secretion (GO:0001956)2.79869874
66regulation of synaptic transmission, dopaminergic (GO:0032225)2.78079142
67regulation of neurotransmitter secretion (GO:0046928)2.77978286
68neuronal ion channel clustering (GO:0045161)2.76728467
69gamma-aminobutyric acid transport (GO:0015812)2.75447706
70layer formation in cerebral cortex (GO:0021819)2.74250999
71L-amino acid import (GO:0043092)2.74227685
72ionotropic glutamate receptor signaling pathway (GO:0035235)2.73235822
73regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.72355722
74neurotransmitter secretion (GO:0007269)2.71597132
75intraciliary transport (GO:0042073)2.71465381
76sequestering of actin monomers (GO:0042989)2.71157529
77positive regulation of mast cell activation (GO:0033005)2.70981771
78response to host immune response (GO:0052572)2.69584542
79response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.69584542
80cellular extravasation (GO:0045123)2.67870724
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.66622110
82regulation of postsynaptic membrane potential (GO:0060078)2.65107410
83synaptic vesicle transport (GO:0048489)2.64668156
84establishment of synaptic vesicle localization (GO:0097480)2.64668156
85regulation of dopamine secretion (GO:0014059)2.64522320
86auditory behavior (GO:0031223)2.63867845
87protein localization to cilium (GO:0061512)2.62671122
88glutamate receptor signaling pathway (GO:0007215)2.60984338
89olfactory bulb development (GO:0021772)2.60200512
90myeloid cell activation involved in immune response (GO:0002275)2.57933704
91regulation of synaptic transmission, glutamatergic (GO:0051966)2.57134663
92gamma-aminobutyric acid signaling pathway (GO:0007214)2.57092212
93positive regulation of dendritic spine morphogenesis (GO:0061003)2.54292758
94G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.54157955
95regulation of glutamate receptor signaling pathway (GO:1900449)2.52787100
96positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.52010049
97behavioral response to nicotine (GO:0035095)2.51912134
98regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.51049508
99detection of biotic stimulus (GO:0009595)2.50388975
100establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.49491780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.72398243
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.61120126
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.94994924
4REST_21632747_ChIP-Seq_MESCs_Mouse2.90606176
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.45312150
6REST_18959480_ChIP-ChIP_MESCs_Mouse2.44440958
7GBX2_23144817_ChIP-Seq_PC3_Human2.31140378
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26583281
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22014522
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.18228323
11TAF15_26573619_Chip-Seq_HEK293_Human2.08236834
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.04212183
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.01869529
14DROSHA_22980978_ChIP-Seq_HELA_Human1.97612515
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97482137
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85848321
17SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85729065
18POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.80668690
19TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80668690
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.79577746
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79164847
22IGF1R_20145208_ChIP-Seq_DFB_Human1.77744456
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.72535873
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69601602
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68993689
26RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.67404493
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61339285
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60458378
29RNF2_27304074_Chip-Seq_NSC_Mouse1.59525877
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52711757
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.51634467
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.50233529
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48799833
34RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44732186
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44296159
36P300_19829295_ChIP-Seq_ESCs_Human1.44203201
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41955131
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40145258
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40145258
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.37037308
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33383143
42ZNF274_21170338_ChIP-Seq_K562_Hela1.30895989
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30071579
44FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27899649
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26213365
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25402438
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24982627
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24352543
49IRF1_19129219_ChIP-ChIP_H3396_Human1.24166309
50TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20575154
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19550046
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19105685
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.18399625
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16584380
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15369895
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14201641
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13070382
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12442617
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.09999588
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09306316
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08483888
62* RUNX2_22187159_ChIP-Seq_PCA_Human1.06782666
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06377602
64KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06041277
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05499032
66* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05258955
67EGR1_19032775_ChIP-ChIP_M12_Human1.04511222
68SMAD4_21799915_ChIP-Seq_A2780_Human1.03647049
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03053585
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00782515
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.00312871
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99588842
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99412829
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98800144
75ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98712698
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96879389
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96702611
78SMAD3_21741376_ChIP-Seq_EPCs_Human0.96509143
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96390264
80FLI1_21867929_ChIP-Seq_TH2_Mouse0.96063415
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95878240
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95192440
83RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94794302
84IRF8_27001747_Chip-Seq_BMDM_Mouse0.93198460
85DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92303385
86VDR_22108803_ChIP-Seq_LS180_Human0.91818929
87SMAD3_21741376_ChIP-Seq_ESCs_Human0.89210406
88SOX2_21211035_ChIP-Seq_LN229_Gbm0.87583790
89TAL1_26923725_Chip-Seq_HPCs_Mouse0.87485747
90FUS_26573619_Chip-Seq_HEK293_Human0.85560527
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85357091
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.84840567
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84747612
94KDM2B_26808549_Chip-Seq_REH_Human0.83053389
95DPY_21335234_ChIP-Seq_ESCs_Mouse0.82717886
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82708699
97JUN_21703547_ChIP-Seq_K562_Human0.82371101
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.81821383
99AR_25329375_ChIP-Seq_VCAP_Human0.81539224
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.81422267

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.85723804
2MP0004859_abnormal_synaptic_plasticity3.84475338
3MP0003122_maternal_imprinting3.28044961
4MP0003787_abnormal_imprinting3.23829591
5MP0002653_abnormal_ependyma_morphology2.95322071
6MP0006292_abnormal_olfactory_placode2.89039239
7MP0003635_abnormal_synaptic_transmissio2.64734320
8MP0000569_abnormal_digit_pigmentation2.57836254
9MP0002822_catalepsy2.42476259
10MP0003121_genomic_imprinting2.33723952
11MP0009745_abnormal_behavioral_response2.26959040
12MP0002063_abnormal_learning/memory/cond2.26096258
13MP0002064_seizures2.25189435
14MP0004270_analgesia2.24159947
15MP0002272_abnormal_nervous_system2.22356449
16MP0001486_abnormal_startle_reflex2.18412537
17MP0003724_increased_susceptibility_to2.16841783
18MP0000778_abnormal_nervous_system2.10957488
19MP0005423_abnormal_somatic_nervous2.07719579
20MP0001968_abnormal_touch/_nociception2.02875212
21MP0003123_paternal_imprinting1.94671939
22MP0002102_abnormal_ear_morphology1.91289502
23MP0005248_abnormal_Harderian_gland1.86874913
24MP0003878_abnormal_ear_physiology1.86105990
25MP0005377_hearing/vestibular/ear_phenot1.86105990
26MP0009046_muscle_twitch1.85019527
27MP0002572_abnormal_emotion/affect_behav1.82012207
28MP0002734_abnormal_mechanical_nocicepti1.80505652
29MP0002736_abnormal_nociception_after1.71254089
30MP0008877_abnormal_DNA_methylation1.68130869
31MP0006276_abnormal_autonomic_nervous1.63728669
32MP0001188_hyperpigmentation1.63489111
33MP0001986_abnormal_taste_sensitivity1.55648145
34MP0004811_abnormal_neuron_physiology1.55306164
35MP0001501_abnormal_sleep_pattern1.54721316
36MP0002067_abnormal_sensory_capabilities1.50596085
37MP0004742_abnormal_vestibular_system1.49941707
38MP0003303_peritoneal_inflammation1.49671427
39MP0001984_abnormal_olfaction1.49326046
40MP0001970_abnormal_pain_threshold1.48161922
41MP0005499_abnormal_olfactory_system1.43200928
42MP0005394_taste/olfaction_phenotype1.43200928
43MP0004142_abnormal_muscle_tone1.42723572
44MP0001485_abnormal_pinna_reflex1.42398840
45MP0001529_abnormal_vocalization1.40390966
46MP0001293_anophthalmia1.35832189
47MP0002735_abnormal_chemical_nociception1.33896422
48MP0002733_abnormal_thermal_nociception1.33883215
49MP0008260_abnormal_autophagy1.32487889
50MP0003690_abnormal_glial_cell1.31999695
51MP0000955_abnormal_spinal_cord1.30501403
52MP0002557_abnormal_social/conspecific_i1.26429249
53MP0008569_lethality_at_weaning1.24762589
54MP0002882_abnormal_neuron_morphology1.21692110
55MP0001440_abnormal_grooming_behavior1.21657584
56MP0003329_amyloid_beta_deposits1.19482957
57MP0008789_abnormal_olfactory_epithelium1.14313266
58MP0002152_abnormal_brain_morphology1.11709640
59MP0003633_abnormal_nervous_system1.11510146
60MP0000015_abnormal_ear_pigmentation1.08759701
61MP0009278_abnormal_bone_marrow1.08346936
62MP0005174_abnormal_tail_pigmentation1.03761803
63MP0001963_abnormal_hearing_physiology1.01039244
64MP0003436_decreased_susceptibility_to1.00208341
65MP0003172_abnormal_lysosome_physiology0.99725995
66MP0002419_abnormal_innate_immunity0.99660012
67MP0009764_decreased_sensitivity_to0.97000331
68MP0002066_abnormal_motor_capabilities/c0.94822915
69MP0002752_abnormal_somatic_nervous0.93795878
70MP0001324_abnormal_eye_pigmentation0.91941179
71MP0003631_nervous_system_phenotype0.91856080
72MP0009379_abnormal_foot_pigmentation0.90936661
73MP0003938_abnormal_ear_development0.90573614
74MP0002095_abnormal_skin_pigmentation0.89872675
75MP0000631_abnormal_neuroendocrine_gland0.89655956
76MP0003136_yellow_coat_color0.89098878
77MP0005386_behavior/neurological_phenoty0.88751146
78MP0004924_abnormal_behavior0.88751146
79MP0001905_abnormal_dopamine_level0.85975404
80MP0000604_amyloidosis0.85214126
81MP0000026_abnormal_inner_ear0.85077314
82MP0002928_abnormal_bile_duct0.85050853
83MP0005075_abnormal_melanosome_morpholog0.85024015
84MP0005171_absent_coat_pigmentation0.84920854
85MP0002277_abnormal_respiratory_mucosa0.84208590
86MP0005551_abnormal_eye_electrophysiolog0.82783746
87MP0005167_abnormal_blood-brain_barrier0.82079466
88MP0003879_abnormal_hair_cell0.82011471
89MP0004885_abnormal_endolymph0.82001855
90MP0010030_abnormal_orbit_morphology0.79974009
91MP0002638_abnormal_pupillary_reflex0.79812460
92MP0002229_neurodegeneration0.79704107
93MP0000920_abnormal_myelination0.79404394
94MP0002184_abnormal_innervation0.78123146
95MP0005253_abnormal_eye_physiology0.76079361
96MP0004133_heterotaxia0.74248707
97MP0003861_abnormal_nervous_system0.73466335
98MP0009785_altered_susceptibility_to0.71718647
99MP0005195_abnormal_posterior_eye0.70340931
100MP0006082_CNS_inflammation0.69072927

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.84651329
2Focal motor seizures (HP:0011153)4.24079029
3Febrile seizures (HP:0002373)3.81480633
4Focal seizures (HP:0007359)3.57518071
5Polyphagia (HP:0002591)3.46768764
6Limb dystonia (HP:0002451)3.20135617
7Atonic seizures (HP:0010819)3.19467366
8Recurrent bacterial skin infections (HP:0005406)3.06691169
9Septo-optic dysplasia (HP:0100842)2.99898295
10Progressive cerebellar ataxia (HP:0002073)2.98972144
11Optic neuritis (HP:0100653)2.96712382
12Retrobulbar optic neuritis (HP:0100654)2.96712382
13Agnosia (HP:0010524)2.92688750
14Gait imbalance (HP:0002141)2.88509605
15Orchitis (HP:0100796)2.83309376
16Mutism (HP:0002300)2.78875579
17Abnormal eating behavior (HP:0100738)2.77029960
18Myositis (HP:0100614)2.76659729
19Action tremor (HP:0002345)2.75933909
20Epileptic encephalopathy (HP:0200134)2.75297256
21Stomatitis (HP:0010280)2.75002419
22Agitation (HP:0000713)2.64402917
23Recurrent abscess formation (HP:0002722)2.59515097
24Hypochromic microcytic anemia (HP:0004840)2.55368051
25Dialeptic seizures (HP:0011146)2.53185210
26Inappropriate behavior (HP:0000719)2.53071417
27Disinhibition (HP:0000734)2.52728027
28Generalized tonic-clonic seizures (HP:0002069)2.51625853
29Amyotrophic lateral sclerosis (HP:0007354)2.51074814
30Postural instability (HP:0002172)2.50937111
31Visual hallucinations (HP:0002367)2.47771770
32Congenital primary aphakia (HP:0007707)2.46235953
33Impaired vibration sensation in the lower limbs (HP:0002166)2.45810612
34Diplopia (HP:0000651)2.42343761
35Abnormality of binocular vision (HP:0011514)2.42343761
36Recurrent gram-negative bacterial infections (HP:0005420)2.40886116
37Excessive salivation (HP:0003781)2.40633642
38Peripheral hypomyelination (HP:0007182)2.40583200
39Growth hormone deficiency (HP:0000824)2.36906865
40Drooling (HP:0002307)2.36361378
41Nephrogenic diabetes insipidus (HP:0009806)2.33849854
42Spastic gait (HP:0002064)2.33619823
43Medial flaring of the eyebrow (HP:0010747)2.30852362
44Oligodactyly (hands) (HP:0001180)2.30176336
45Colon cancer (HP:0003003)2.28950093
46Urinary bladder sphincter dysfunction (HP:0002839)2.27669737
47True hermaphroditism (HP:0010459)2.22060490
48Iris hypopigmentation (HP:0007730)2.21670765
49Elevated erythrocyte sedimentation rate (HP:0003565)2.21653901
50Absence seizures (HP:0002121)2.20794447
51Anophthalmia (HP:0000528)2.17912737
52Abnormality of the labia minora (HP:0012880)2.17463266
53Papilledema (HP:0001085)2.17332764
54Supranuclear gaze palsy (HP:0000605)2.16957868
55Nephronophthisis (HP:0000090)2.15889350
56Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.10995060
57Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.10508253
58Pancreatic fibrosis (HP:0100732)2.10181133
59Specific learning disability (HP:0001328)2.09861182
60Oligodactyly (HP:0012165)2.06792885
61Broad-based gait (HP:0002136)2.03080907
62Amyloidosis (HP:0011034)2.02765368
63Keratoconjunctivitis sicca (HP:0001097)2.01928362
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01927032
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.01927032
66Sleep apnea (HP:0010535)1.98518691
67Optic nerve hypoplasia (HP:0000609)1.98477295
68Abnormality of the corticospinal tract (HP:0002492)1.97376152
69Dyskinesia (HP:0100660)1.96001929
70Abnormality of macrophages (HP:0004311)1.95625395
71Breast aplasia (HP:0100783)1.95213546
72Amblyopia (HP:0000646)1.95014689
73Vaginal atresia (HP:0000148)1.93910392
74Erectile abnormalities (HP:0100639)1.92837020
75Eczematoid dermatitis (HP:0000976)1.91096369
76Genital tract atresia (HP:0001827)1.90420547
77Urinary urgency (HP:0000012)1.89359900
78Obstructive lung disease (HP:0006536)1.87823987
79Chronic obstructive pulmonary disease (HP:0006510)1.87823987
80Hip dysplasia (HP:0001385)1.86748644
81Ocular albinism (HP:0001107)1.86626891
82Absent septum pellucidum (HP:0001331)1.86242634
83Molar tooth sign on MRI (HP:0002419)1.85410906
84Abnormality of midbrain morphology (HP:0002418)1.85410906
85Aplasia/Hypoplasia of the breasts (HP:0010311)1.84660684
86Keratoconjunctivitis (HP:0001096)1.83760571
87Poor coordination (HP:0002370)1.80201996
88Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80162674
89Morphological abnormality of the pyramidal tract (HP:0002062)1.78993946
90Abnormal social behavior (HP:0012433)1.77231523
91Impaired social interactions (HP:0000735)1.77231523
92Status epilepticus (HP:0002133)1.76837958
93Hemiplegia (HP:0002301)1.76736145
94Rib fusion (HP:0000902)1.76044395
95Annular pancreas (HP:0001734)1.75210666
96Pancreatic cysts (HP:0001737)1.74371541
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74180430
98Broad foot (HP:0001769)1.74039597
99Cortical dysplasia (HP:0002539)1.73499341
100Mediastinal lymphadenopathy (HP:0100721)1.71833817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.40020931
2CDK193.34254505
3RIPK42.80009815
4CASK2.40192380
5MARK12.23472234
6MINK12.18345574
7UHMK12.11536668
8DYRK32.08916085
9MAP3K42.00618579
10MAP2K71.98442019
11FGR1.98111569
12DAPK21.95349061
13NTRK21.87735368
14MAP2K41.83249670
15TNIK1.80286944
16PAK61.77580551
17NTRK31.74657627
18MAP3K111.67262489
19DYRK21.65403648
20MAPK131.63653866
21WNK31.46159111
22BLK1.44971479
23PLK21.43899097
24CAMKK21.43392600
25CAMKK11.41895060
26DYRK1A1.35988530
27DYRK1B1.33997171
28MARK21.29650984
29TYRO31.29307650
30STK111.28085518
31FES1.26809415
32PRKCG1.18727479
33CAMK11.15977909
34PINK11.15726675
35TNK21.14338561
36SGK2231.11922609
37SGK4941.11922609
38CSNK1G21.11772286
39IRAK41.10970784
40CDK51.10741695
41CSK1.09921022
42GRK51.05420755
43SGK21.04454873
44SIK21.04432566
45CAMK41.00201585
46IRAK20.98896712
47TAOK10.98138091
48KSR10.95248855
49MAP3K60.91990567
50MKNK20.90518896
51PAK30.85357168
52CDK140.83970967
53BCR0.83170163
54MAP3K90.82807075
55MKNK10.82633264
56TRIM280.81304679
57OXSR10.81228064
58MATK0.78854144
59BRAF0.78029942
60SGK30.76593111
61CDK150.75723612
62CDK180.75331169
63CDC70.74793958
64CSNK1G30.74077995
65CDK11A0.72802869
66JAK20.71604307
67PRKCH0.70921642
68RPS6KA40.70262432
69SYK0.69666114
70TYK20.68921960
71ERBB20.65187316
72PNCK0.64349211
73PTK2B0.63214784
74PRKCZ0.61299001
75CAMK2A0.59386926
76YES10.59154937
77MAP2K30.59036714
78ADRBK20.58924147
79SGK10.58749190
80PRKD30.58109460
81CSNK1A1L0.57948598
82KSR20.55635312
83TXK0.55491772
84GRK70.54598234
85GRK60.52470360
86LYN0.51446371
87CSNK1G10.51238462
88FYN0.51132582
89CAMK1G0.50800977
90PLK30.49712783
91HCK0.47145926
92ALK0.44585897
93MAP3K50.43980876
94BCKDK0.43511327
95BTK0.42219866
96IKBKE0.40243914
97MAP4K20.40003203
98MARK30.38898094
99SRPK10.35115362
100CAMK1D0.35076237

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.35432061
2Morphine addiction_Homo sapiens_hsa050322.75429372
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72979145
4Synaptic vesicle cycle_Homo sapiens_hsa047212.67068963
5GABAergic synapse_Homo sapiens_hsa047272.60281973
6Glutamatergic synapse_Homo sapiens_hsa047242.17620254
7Circadian entrainment_Homo sapiens_hsa047132.04863410
8Dopaminergic synapse_Homo sapiens_hsa047282.03859862
9Osteoclast differentiation_Homo sapiens_hsa043801.93596351
10Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.83443304
11Long-term potentiation_Homo sapiens_hsa047201.80419134
12Cocaine addiction_Homo sapiens_hsa050301.77596254
13Amphetamine addiction_Homo sapiens_hsa050311.71401899
14Cholinergic synapse_Homo sapiens_hsa047251.66884623
15Collecting duct acid secretion_Homo sapiens_hsa049661.66760568
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66478919
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.58889945
18Taste transduction_Homo sapiens_hsa047421.51977533
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50560025
20Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.47786663
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45151652
22Tuberculosis_Homo sapiens_hsa051521.43060683
23Serotonergic synapse_Homo sapiens_hsa047261.37461408
24Chemokine signaling pathway_Homo sapiens_hsa040621.36051631
25Parkinsons disease_Homo sapiens_hsa050121.35567030
26Axon guidance_Homo sapiens_hsa043601.34022317
27Leishmaniasis_Homo sapiens_hsa051401.33151668
28Long-term depression_Homo sapiens_hsa047301.25466137
29Gastric acid secretion_Homo sapiens_hsa049711.25338512
30Olfactory transduction_Homo sapiens_hsa047401.24205763
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23101799
32Insulin secretion_Homo sapiens_hsa049111.22528007
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22282651
34Regulation of autophagy_Homo sapiens_hsa041401.17302889
35Oxytocin signaling pathway_Homo sapiens_hsa049211.15455606
36Oxidative phosphorylation_Homo sapiens_hsa001901.15099226
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15044685
38Cardiac muscle contraction_Homo sapiens_hsa042601.14653084
39cAMP signaling pathway_Homo sapiens_hsa040241.07762419
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05462584
41Phagosome_Homo sapiens_hsa041451.05453110
42GnRH signaling pathway_Homo sapiens_hsa049121.03647191
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00761262
44Salmonella infection_Homo sapiens_hsa051320.99398722
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98659352
46Malaria_Homo sapiens_hsa051440.98449396
47Alzheimers disease_Homo sapiens_hsa050100.97610568
48Hedgehog signaling pathway_Homo sapiens_hsa043400.96604265
49Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95048817
50Phototransduction_Homo sapiens_hsa047440.94673406
51Staphylococcus aureus infection_Homo sapiens_hsa051500.93713036
52Gap junction_Homo sapiens_hsa045400.93544749
53Melanogenesis_Homo sapiens_hsa049160.91557253
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89708768
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87042089
56Calcium signaling pathway_Homo sapiens_hsa040200.84411387
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.83619099
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80495280
59Type II diabetes mellitus_Homo sapiens_hsa049300.80336762
60MAPK signaling pathway_Homo sapiens_hsa040100.79987236
61VEGF signaling pathway_Homo sapiens_hsa043700.79844949
62Oocyte meiosis_Homo sapiens_hsa041140.79594719
63Salivary secretion_Homo sapiens_hsa049700.78890604
64Rap1 signaling pathway_Homo sapiens_hsa040150.76894468
65Huntingtons disease_Homo sapiens_hsa050160.76091051
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.76083214
67Colorectal cancer_Homo sapiens_hsa052100.75611424
68ErbB signaling pathway_Homo sapiens_hsa040120.72248298
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69853592
70Basal cell carcinoma_Homo sapiens_hsa052170.69418966
71Legionellosis_Homo sapiens_hsa051340.68836749
72Renin secretion_Homo sapiens_hsa049240.67659784
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65537263
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65098904
75Steroid biosynthesis_Homo sapiens_hsa001000.65013754
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64873436
77Ras signaling pathway_Homo sapiens_hsa040140.64011831
78B cell receptor signaling pathway_Homo sapiens_hsa046620.63205364
79Wnt signaling pathway_Homo sapiens_hsa043100.62908668
80Notch signaling pathway_Homo sapiens_hsa043300.61181107
81Alcoholism_Homo sapiens_hsa050340.59797089
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59480031
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58178297
84Rheumatoid arthritis_Homo sapiens_hsa053230.55658067
85African trypanosomiasis_Homo sapiens_hsa051430.55233589
86Estrogen signaling pathway_Homo sapiens_hsa049150.55199743
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54563096
88Ether lipid metabolism_Homo sapiens_hsa005650.53948704
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51972316
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51378062
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50881954
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47790533
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.47058568
94Choline metabolism in cancer_Homo sapiens_hsa052310.46081612
95Prolactin signaling pathway_Homo sapiens_hsa049170.43813700
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43807033
97Inositol phosphate metabolism_Homo sapiens_hsa005620.42859348
98Pertussis_Homo sapiens_hsa051330.42580578
99Dorso-ventral axis formation_Homo sapiens_hsa043200.41005068
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39508110

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