RNF180

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact5.41790762
2modulation by symbiont of host immune response (GO:0052553)5.41790762
3positive regulation by symbiont of host defense response (GO:0052509)5.41790762
4modulation by symbiont of host defense response (GO:0052031)5.41790762
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.41790762
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.41790762
7microglial cell activation (GO:0001774)5.17872109
8positive regulation of cellular amide metabolic process (GO:0034250)4.65911158
9pyrimidine nucleobase catabolic process (GO:0006208)4.35530150
10C4-dicarboxylate transport (GO:0015740)4.15682713
11macrophage activation involved in immune response (GO:0002281)4.14816412
12auditory behavior (GO:0031223)3.94493187
13regulation of interferon-beta biosynthetic process (GO:0045357)3.93553490
14neuron cell-cell adhesion (GO:0007158)3.88087848
15response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.87294598
16response to host immune response (GO:0052572)3.87294598
17nucleobase catabolic process (GO:0046113)3.79327873
18gamma-aminobutyric acid transport (GO:0015812)3.73297333
19mechanosensory behavior (GO:0007638)3.72339687
20locomotory exploration behavior (GO:0035641)3.68550548
21positive regulation of heat generation (GO:0031652)3.68139434
22positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.48359672
23G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.42851485
24neuronal action potential propagation (GO:0019227)3.42496987
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.41096802
26regulation of synapse structural plasticity (GO:0051823)3.40024819
27postsynaptic membrane organization (GO:0001941)3.39610983
28response to host (GO:0075136)3.33479304
29response to host defenses (GO:0052200)3.33479304
30response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.33479304
31positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.32745369
32response to auditory stimulus (GO:0010996)3.32247112
33negative regulation of cytosolic calcium ion concentration (GO:0051481)3.32153437
34amino acid import (GO:0043090)3.30648942
35negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28497164
36neurotransmitter-gated ion channel clustering (GO:0072578)3.26598572
37negative regulation of homotypic cell-cell adhesion (GO:0034111)3.25712188
38positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21867092
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20071150
40positive regulation of antigen processing and presentation (GO:0002579)3.16051337
41axonal fasciculation (GO:0007413)3.15014246
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14523649
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.14058645
44negative regulation of interleukin-17 production (GO:0032700)3.13650428
45regulation of fever generation (GO:0031620)3.12724465
46retinal cone cell development (GO:0046549)3.11670829
47regulation of heat generation (GO:0031650)3.08727058
48T-helper 1 type immune response (GO:0042088)3.06449609
49macrophage activation (GO:0042116)3.05465844
50regulation of glutamate receptor signaling pathway (GO:1900449)3.05371539
51vocalization behavior (GO:0071625)3.03852511
52regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.03348349
53presynaptic membrane assembly (GO:0097105)3.02939448
54behavioral response to ethanol (GO:0048149)3.02201564
55L-amino acid import (GO:0043092)3.00811921
56dendritic spine morphogenesis (GO:0060997)2.99845584
57regulation of synaptic transmission, glutamatergic (GO:0051966)2.97086840
58nonmotile primary cilium assembly (GO:0035058)2.92803255
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.92650508
60startle response (GO:0001964)2.90162764
61lens fiber cell differentiation (GO:0070306)2.89966757
62chondroitin sulfate catabolic process (GO:0030207)2.85570167
63synaptic vesicle exocytosis (GO:0016079)2.84044039
64exploration behavior (GO:0035640)2.81405004
65positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79826885
66establishment of protein localization to Golgi (GO:0072600)2.78272109
67regulation of neurotransmitter uptake (GO:0051580)2.77894478
68neuron recognition (GO:0008038)2.77514434
69glycosphingolipid catabolic process (GO:0046479)2.76039658
70limb bud formation (GO:0060174)2.75650922
71intraciliary transport (GO:0042073)2.74613873
72ionotropic glutamate receptor signaling pathway (GO:0035235)2.73837102
73regulation of dendritic cell antigen processing and presentation (GO:0002604)2.73093170
74synapse assembly (GO:0007416)2.71733591
75calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.71683046
76positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.69093038
77retinal ganglion cell axon guidance (GO:0031290)2.64434466
78response to peptidoglycan (GO:0032494)2.64162371
79negative regulation of neurotransmitter transport (GO:0051589)2.64099358
80protein targeting to Golgi (GO:0000042)2.63927611
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.63191845
82transmission of nerve impulse (GO:0019226)2.62837717
83positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.62183721
84neurotransmitter uptake (GO:0001504)2.61906798
85central nervous system projection neuron axonogenesis (GO:0021952)2.61742491
86regulation of respiratory system process (GO:0044065)2.61633352
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60541014
88regulation of interleukin-17 production (GO:0032660)2.57519534
89regulation of activation of Janus kinase activity (GO:0010533)2.57041000
90positive regulation of chemokine biosynthetic process (GO:0045080)2.56651335
91behavioral response to nicotine (GO:0035095)2.56510517
92neural tube formation (GO:0001841)2.56341246
93regulation of short-term neuronal synaptic plasticity (GO:0048172)2.55624947
94auditory receptor cell stereocilium organization (GO:0060088)2.55438575
95regulation of platelet aggregation (GO:0090330)2.55399082
96negative regulation of oligodendrocyte differentiation (GO:0048715)2.55141365
97central nervous system neuron axonogenesis (GO:0021955)2.53761626
98cellular ketone body metabolic process (GO:0046950)2.53015083
99neuron-neuron synaptic transmission (GO:0007270)2.52534787
100protein localization to cilium (GO:0061512)2.51468361
101glycosphingolipid biosynthetic process (GO:0006688)2.51380546
102positive regulation of interleukin-17 production (GO:0032740)2.50701745
103reflex (GO:0060004)2.50582422
104righting reflex (GO:0060013)2.49909906
105synaptic transmission, glutamatergic (GO:0035249)2.49627541
106long-term synaptic potentiation (GO:0060291)2.49200220
107regulation of beta-amyloid formation (GO:1902003)2.46299176
108response to pheromone (GO:0019236)2.44688726
109inner ear receptor stereocilium organization (GO:0060122)2.44520716
110retrograde transport, vesicle recycling within Golgi (GO:0000301)2.44347163
111cilium morphogenesis (GO:0060271)2.44237804
112lens fiber cell development (GO:0070307)2.43878628
113regulation of timing of cell differentiation (GO:0048505)2.43850263
114establishment of mitochondrion localization (GO:0051654)2.43547478
115brain morphogenesis (GO:0048854)2.43412575
116positive regulation of interferon-alpha production (GO:0032727)2.42535553
117ketone body metabolic process (GO:1902224)2.42519570
118regulation of cardiac muscle cell contraction (GO:0086004)2.42424432
119retinal rod cell development (GO:0046548)2.42404581
120lens development in camera-type eye (GO:0002088)2.42077789
121neuronal action potential (GO:0019228)2.41545324
122acidic amino acid transport (GO:0015800)2.41216888
123epithelial cilium movement (GO:0003351)2.40459990
124photoreceptor cell differentiation (GO:0046530)2.39943807
125eye photoreceptor cell differentiation (GO:0001754)2.39943807
126detection of light stimulus involved in sensory perception (GO:0050962)2.39510381
127detection of light stimulus involved in visual perception (GO:0050908)2.39510381
128positive regulation of potassium ion transmembrane transport (GO:1901381)2.38833331
129vascular smooth muscle contraction (GO:0014829)2.36701794
130myeloid cell activation involved in immune response (GO:0002275)2.36675798
131gamma-aminobutyric acid signaling pathway (GO:0007214)2.36662243
132cilium organization (GO:0044782)2.36644519
133regulation of memory T cell differentiation (GO:0043380)2.36033672
134glycolipid catabolic process (GO:0019377)2.35967471
135synapse organization (GO:0050808)2.34812232
136regulation of antigen processing and presentation (GO:0002577)2.34483409
137positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.34336994
138detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.33723597
139response to cholesterol (GO:0070723)2.33199465
140positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.32843795
141glutamate receptor signaling pathway (GO:0007215)2.32459056
142cilium assembly (GO:0042384)2.32306036
143regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.31915754
144presynaptic membrane organization (GO:0097090)2.31411121
145cerebellar granule cell differentiation (GO:0021707)2.31167023
146protein localization to Golgi apparatus (GO:0034067)2.30802930
147membrane depolarization during action potential (GO:0086010)2.30306545
148positive regulation of synapse assembly (GO:0051965)2.30053608
149photoreceptor cell maintenance (GO:0045494)2.29913248
150synaptic vesicle maturation (GO:0016188)2.29488140
151protein polyglutamylation (GO:0018095)2.28551956
152positive regulation of synaptic transmission, GABAergic (GO:0032230)2.28527013
153regulation of interferon-gamma biosynthetic process (GO:0045072)2.27925941
154regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.27799676
155photoreceptor cell development (GO:0042461)2.25890535
156glial cell proliferation (GO:0014009)2.25240074
157regulation of interferon-alpha production (GO:0032647)2.25086810
158cerebral cortex cell migration (GO:0021795)2.24670405
159detection of calcium ion (GO:0005513)2.24667518
160neuromuscular synaptic transmission (GO:0007274)2.24543336
161positive regulation of interleukin-12 production (GO:0032735)2.24523440
162regulation of T-helper 1 cell differentiation (GO:0045625)2.23343454
163regulation of cilium movement (GO:0003352)2.23240704
164phagosome maturation (GO:0090382)2.22766455
165dendrite morphogenesis (GO:0048813)2.22151471
166regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.22017913
167cerebral cortex radially oriented cell migration (GO:0021799)2.21736542
168glutamate secretion (GO:0014047)2.21541963
169G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.20080978
170negative regulation of platelet activation (GO:0010544)2.19893268
171lipopolysaccharide-mediated signaling pathway (GO:0031663)2.19768764
172positive regulation of monocyte chemotaxis (GO:0090026)2.19241543
173ceramide catabolic process (GO:0046514)2.18994161
174protein localization to synapse (GO:0035418)2.15867582
175negative regulation of astrocyte differentiation (GO:0048712)2.14167151
176regulation of NFAT protein import into nucleus (GO:0051532)2.12794640
177G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.09994519

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.16953859
2EZH2_22144423_ChIP-Seq_EOC_Human2.97626542
3ZNF274_21170338_ChIP-Seq_K562_Hela2.54561633
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46892863
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33093281
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29513582
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.22671974
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.21511733
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08478117
10AR_21572438_ChIP-Seq_LNCaP_Human2.07842370
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07357859
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05673027
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03315834
14JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99345704
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98113802
16SALL1_21062744_ChIP-ChIP_HESCs_Human1.88200002
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.86390862
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82874496
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78350034
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77881559
21* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77794141
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76106607
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74813838
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.73912309
25REST_21632747_ChIP-Seq_MESCs_Mouse1.73789558
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73514729
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73353744
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72879811
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71860027
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71860027
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.70772357
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.70373554
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70329876
34DROSHA_22980978_ChIP-Seq_HELA_Human1.68804059
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68741964
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.66848208
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64800647
38SMAD4_21799915_ChIP-Seq_A2780_Human1.64721960
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.64306498
40P300_19829295_ChIP-Seq_ESCs_Human1.64189639
41EWS_26573619_Chip-Seq_HEK293_Human1.63831010
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63591196
43VDR_24787735_ChIP-Seq_THP-1_Human1.58292149
44IGF1R_20145208_ChIP-Seq_DFB_Human1.57583609
45* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55547375
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54183951
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.53237153
48* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52016752
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.51723810
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51485070
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50411806
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48093778
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47427621
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46221377
55CBP_20019798_ChIP-Seq_JUKART_Human1.46221377
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45369905
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43411616
58* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42878690
59* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42171816
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.39160419
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37902244
62* EZH2_27294783_Chip-Seq_ESCs_Mouse1.37576415
63AHR_22903824_ChIP-Seq_MCF-7_Human1.37457830
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36195932
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36121606
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34769684
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33558194
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32149993
69SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31787285
70AR_25329375_ChIP-Seq_VCAP_Human1.30642450
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30030373
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30030373
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29735142
74TCF4_22108803_ChIP-Seq_LS180_Human1.29266563
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27197295
76FUS_26573619_Chip-Seq_HEK293_Human1.26478357
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.26258560
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24818406
79ER_23166858_ChIP-Seq_MCF-7_Human1.22709121
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22409760
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22301126
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.21243724
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.21208833
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20678961
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17979629
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.17939966
87* TAL1_26923725_Chip-Seq_HPCs_Mouse1.17747518
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17743998
89TAF15_26573619_Chip-Seq_HEK293_Human1.16505913
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16299895
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15367215
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15312510
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.15265597
94* STAT3_23295773_ChIP-Seq_U87_Human1.14575442
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13662240
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13156091
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12518311
98* TCF4_23295773_ChIP-Seq_U87_Human1.11436773
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11317181
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11126465
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.10332191
102SMAD3_21741376_ChIP-Seq_ESCs_Human1.09842372
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08405546
104NFE2_27457419_Chip-Seq_LIVER_Mouse1.08020728
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.07612390
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.07596371
107JUN_21703547_ChIP-Seq_K562_Human1.05852221
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05209296
109TP53_18474530_ChIP-ChIP_U2OS_Human1.04794441
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04596004
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03779476
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03714550
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02330708
114BCAT_22108803_ChIP-Seq_LS180_Human1.02080517
115RUNX2_22187159_ChIP-Seq_PCA_Human1.01417079
116YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01221268
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00940149
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00940149
119TP53_16413492_ChIP-PET_HCT116_Human1.00343824
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00301978
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00084685
122SOX9_26525672_Chip-Seq_HEART_Mouse0.99927448
123CMYC_18555785_Chip-Seq_ESCs_Mouse0.99885439
124E2F1_18555785_Chip-Seq_ESCs_Mouse0.99756620
125LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98762647
126RNF2_27304074_Chip-Seq_NSC_Mouse0.98163879
127KDM2B_26808549_Chip-Seq_REH_Human0.97179287
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96964764
129BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96474714
130ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96341882
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95927991
132RARB_27405468_Chip-Seq_BRAIN_Mouse0.94859478
133VDR_22108803_ChIP-Seq_LS180_Human0.94264003
134P53_22387025_ChIP-Seq_ESCs_Mouse0.94197258

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism3.85806587
2MP0004858_abnormal_nervous_system3.29096016
3MP0002254_reproductive_system_inflammat3.03200327
4MP0004859_abnormal_synaptic_plasticity3.02103943
5MP0000569_abnormal_digit_pigmentation2.84984771
6MP0002735_abnormal_chemical_nociception2.83566829
7MP0005646_abnormal_pituitary_gland2.70023904
8MP0005645_abnormal_hypothalamus_physiol2.46942558
9MP0005058_abnormal_lysosome_morphology2.44694552
10MP0003172_abnormal_lysosome_physiology2.41217531
11MP0002736_abnormal_nociception_after2.29535294
12MP0010386_abnormal_urinary_bladder2.24139017
13MP0005551_abnormal_eye_electrophysiolog2.18331727
14MP0006072_abnormal_retinal_apoptosis2.14640680
15MP0001968_abnormal_touch/_nociception2.07966874
16MP0005253_abnormal_eye_physiology2.06545018
17MP0002063_abnormal_learning/memory/cond1.97757743
18MP0003635_abnormal_synaptic_transmissio1.97158320
19MP0002572_abnormal_emotion/affect_behav1.95210322
20MP0002102_abnormal_ear_morphology1.88190318
21MP0002638_abnormal_pupillary_reflex1.88108375
22MP0006276_abnormal_autonomic_nervous1.86557811
23MP0001835_abnormal_antigen_presentation1.85634925
24MP0005171_absent_coat_pigmentation1.85009762
25MP0002064_seizures1.84586533
26MP0009745_abnormal_behavioral_response1.83904774
27MP0005310_abnormal_salivary_gland1.78974156
28MP0003011_delayed_dark_adaptation1.77651350
29MP0000778_abnormal_nervous_system1.75080082
30MP0001529_abnormal_vocalization1.69862393
31MP0001486_abnormal_startle_reflex1.69590039
32MP0002733_abnormal_thermal_nociception1.68034330
33MP0005187_abnormal_penis_morphology1.64643156
34MP0004510_myositis1.64270406
35MP0003787_abnormal_imprinting1.63419443
36MP0004270_analgesia1.62954638
37MP0003880_abnormal_central_pattern1.62699704
38MP0003690_abnormal_glial_cell1.62131582
39MP0004885_abnormal_endolymph1.61456715
40MP0003136_yellow_coat_color1.61427166
41MP0005248_abnormal_Harderian_gland1.57797053
42MP0002277_abnormal_respiratory_mucosa1.56577483
43MP0002734_abnormal_mechanical_nocicepti1.56432884
44MP0001984_abnormal_olfaction1.55652823
45MP0002837_dystrophic_cardiac_calcinosis1.53443074
46MP0003122_maternal_imprinting1.47947018
47MP0002419_abnormal_innate_immunity1.47585069
48MP0000604_amyloidosis1.46891834
49MP0003634_abnormal_glial_cell1.46281341
50MP0001970_abnormal_pain_threshold1.45947097
51MP0004924_abnormal_behavior1.45108243
52MP0005386_behavior/neurological_phenoty1.45108243
53MP0004215_abnormal_myocardial_fiber1.44800775
54MP0002557_abnormal_social/conspecific_i1.42634887
55MP0002822_catalepsy1.41048970
56MP0004142_abnormal_muscle_tone1.40652761
57MP0005671_abnormal_response_to1.39766122
58MP0003075_altered_response_to1.38774392
59MP0008789_abnormal_olfactory_epithelium1.37033630
60MP0002148_abnormal_hypersensitivity_rea1.36717190
61MP0009046_muscle_twitch1.36212805
62MP0002067_abnormal_sensory_capabilities1.35830495
63MP0001502_abnormal_circadian_rhythm1.34749974
64MP0001501_abnormal_sleep_pattern1.33575307
65MP0006082_CNS_inflammation1.33389561
66MP0003941_abnormal_skin_development1.31993162
67MP0005257_abnormal_intraocular_pressure1.29647022
68MP0002090_abnormal_vision1.29006958
69MP0009780_abnormal_chondrocyte_physiolo1.28053405
70MP0001346_abnormal_lacrimal_gland1.27254850
71MP0000013_abnormal_adipose_tissue1.25972472
72MP0004742_abnormal_vestibular_system1.24022921
73MP0005499_abnormal_olfactory_system1.22847061
74MP0005394_taste/olfaction_phenotype1.22847061
75MP0003633_abnormal_nervous_system1.22027668
76MP0001873_stomach_inflammation1.21595309
77MP0002909_abnormal_adrenal_gland1.20980103
78MP0001853_heart_inflammation1.20421447
79MP0005423_abnormal_somatic_nervous1.18175323
80MP0002938_white_spotting1.17825270
81MP0005379_endocrine/exocrine_gland_phen1.17523893
82MP0000538_abnormal_urinary_bladder1.17493559
83MP0000015_abnormal_ear_pigmentation1.17255651
84MP0000647_abnormal_sebaceous_gland1.16620792
85MP0001986_abnormal_taste_sensitivity1.15453592
86MP0000372_irregular_coat_pigmentation1.14591427
87MP0004043_abnormal_pH_regulation1.14288270
88MP0005174_abnormal_tail_pigmentation1.13509787
89MP0002697_abnormal_eye_size1.12785565
90MP0002184_abnormal_innervation1.11920793
91MP0003879_abnormal_hair_cell1.11110735
92MP0000534_abnormal_ureter_morphology1.10930019
93MP0003121_genomic_imprinting1.10132040
94MP0002234_abnormal_pharynx_morphology1.10017046
95MP0003300_gastrointestinal_ulcer1.08850624
96MP0002876_abnormal_thyroid_physiology1.08726045
97MP0002751_abnormal_autonomic_nervous1.07440719
98MP0000427_abnormal_hair_cycle1.07374594
99MP0002653_abnormal_ependyma_morphology1.07324410
100MP0000631_abnormal_neuroendocrine_gland1.05816471
101MP0004883_abnormal_blood_vessel1.05588509
102MP0002752_abnormal_somatic_nervous1.05119134
103MP0005000_abnormal_immune_tolerance1.04807794
104MP0001790_abnormal_immune_system1.04230645
105MP0005387_immune_system_phenotype1.04230645
106MP0002229_neurodegeneration1.04115413
107MP0001963_abnormal_hearing_physiology1.02965916
108MP0008260_abnormal_autophagy1.02631102
109MP0003195_calcinosis1.02366534
110MP0006292_abnormal_olfactory_placode1.02224865
111MP0005647_abnormal_sex_gland1.01205171
112MP0004145_abnormal_muscle_electrophysio1.01167593
113MP0005195_abnormal_posterior_eye0.98981298
114MP0000685_abnormal_immune_system0.98528401
115MP0002095_abnormal_skin_pigmentation0.96905384
116MP0005391_vision/eye_phenotype0.96319963
117MP0000026_abnormal_inner_ear0.95995451
118MP0002272_abnormal_nervous_system0.95864839
119MP0001299_abnormal_eye_distance/0.94823599
120MP0005167_abnormal_blood-brain_barrier0.94466099
121MP0003137_abnormal_impulse_conducting0.94232854
122MP0001188_hyperpigmentation0.93860641
123MP0001485_abnormal_pinna_reflex0.91490639
124MP0002233_abnormal_nose_morphology0.91472178
125MP0002928_abnormal_bile_duct0.90822169
126MP0003303_peritoneal_inflammation0.90787107
127MP0000383_abnormal_hair_follicle0.90362264
128MP0008877_abnormal_DNA_methylation0.90344445
129MP0002882_abnormal_neuron_morphology0.90266314
130MP0000955_abnormal_spinal_cord0.89910282
131MP0009785_altered_susceptibility_to0.89752356
132MP0002066_abnormal_motor_capabilities/c0.89557177
133MP0004811_abnormal_neuron_physiology0.89286807
134MP0009764_decreased_sensitivity_to0.87790817
135MP0003890_abnormal_embryonic-extraembry0.86913821
136MP0008569_lethality_at_weaning0.84753017
137MP0004133_heterotaxia0.84704751
138MP0000049_abnormal_middle_ear0.84510149
139MP0000516_abnormal_urinary_system0.84492407
140MP0005367_renal/urinary_system_phenotyp0.84492407
141MP0002069_abnormal_eating/drinking_beha0.84028055
142MP0002452_abnormal_antigen_presenting0.83720817
143MP0003631_nervous_system_phenotype0.83151504
144MP0003329_amyloid_beta_deposits0.81698638
145MP0005197_abnormal_uvea_morphology0.81345319
146MP0002723_abnormal_immune_serum0.78383019
147MP0003436_decreased_susceptibility_to0.76788981
148MP0002152_abnormal_brain_morphology0.76447989
149MP0002163_abnormal_gland_morphology0.75003336
150MP0005464_abnormal_platelet_physiology0.74621006
151MP0005025_abnormal_response_to0.74462118

Predicted human phenotypes

RankGene SetZ-score
1Nuclear cataract (HP:0100018)5.92783278
2Zonular cataract (HP:0010920)5.17199484
3Increased cerebral lipofuscin (HP:0011813)3.61070196
4Clumsiness (HP:0002312)3.56418869
5Increased neuronal autofluorescent lipopigment (HP:0002074)3.36994791
6Mediastinal lymphadenopathy (HP:0100721)3.30866173
7Dysostosis multiplex (HP:0000943)3.15436258
8Abnormality of liposaccharide metabolism (HP:0010968)3.14501250
9Abnormality of glycosphingolipid metabolism (HP:0004343)3.14501250
10Abnormality of glycolipid metabolism (HP:0010969)3.14501250
11Pancreatic fibrosis (HP:0100732)3.11297537
12Eczematoid dermatitis (HP:0000976)3.08087994
13Recurrent bacterial skin infections (HP:0005406)3.05639942
14Focal motor seizures (HP:0011153)3.04513706
15Hepatoblastoma (HP:0002884)3.03431994
16Recurrent abscess formation (HP:0002722)2.99003322
17Pancreatic cysts (HP:0001737)2.97900570
18Genital tract atresia (HP:0001827)2.91256725
19Broad-based gait (HP:0002136)2.90303202
20Type II lissencephaly (HP:0007260)2.88403143
21Epileptic encephalopathy (HP:0200134)2.85068828
22Hyperventilation (HP:0002883)2.78982899
23Molar tooth sign on MRI (HP:0002419)2.78467250
24Abnormality of midbrain morphology (HP:0002418)2.78467250
25Vaginal atresia (HP:0000148)2.78233567
26Mutism (HP:0002300)2.76577678
27Arterial tortuosity (HP:0005116)2.74298397
28Gaze-evoked nystagmus (HP:0000640)2.67448825
29Abnormality of the labia minora (HP:0012880)2.61676416
30Oligodactyly (hands) (HP:0001180)2.59812908
31Atonic seizures (HP:0010819)2.56734698
32Nephronophthisis (HP:0000090)2.53469056
33Systemic lupus erythematosus (HP:0002725)2.49820326
34Vacuolated lymphocytes (HP:0001922)2.47902276
35Large eyes (HP:0001090)2.46860762
36Action tremor (HP:0002345)2.45428638
37Limb dystonia (HP:0002451)2.44743440
38Retinal atrophy (HP:0001105)2.40978651
39Lissencephaly (HP:0001339)2.40666063
40Supranuclear gaze palsy (HP:0000605)2.40517537
41Hemiplegia (HP:0002301)2.39538222
42Abnormality of the renal medulla (HP:0100957)2.39517128
43Pulmonary infiltrates (HP:0002113)2.38591531
44Progressive inability to walk (HP:0002505)2.36716057
45Epidermoid cyst (HP:0200040)2.35622067
46Recurrent gram-negative bacterial infections (HP:0005420)2.34917513
47Progressive cerebellar ataxia (HP:0002073)2.34361897
48Cerebellar dysplasia (HP:0007033)2.33613073
49Megalencephaly (HP:0001355)2.33306244
50Febrile seizures (HP:0002373)2.33280299
51Poor coordination (HP:0002370)2.32817049
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.31232319
53Abnormality of polysaccharide metabolism (HP:0011012)2.30416948
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.30416948
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.30416948
56Progressive sensorineural hearing impairment (HP:0000408)2.30164932
57Mucopolysacchariduria (HP:0008155)2.29539644
58Urinary glycosaminoglycan excretion (HP:0003541)2.29539644
59Abnormality of the renal cortex (HP:0011035)2.29025409
60Neurofibrillary tangles (HP:0002185)2.28816128
61Chronic hepatic failure (HP:0100626)2.27980375
62Congenital stationary night blindness (HP:0007642)2.27112817
63Dialeptic seizures (HP:0011146)2.26308992
64Postaxial hand polydactyly (HP:0001162)2.25489745
65Astrocytoma (HP:0009592)2.25479825
66Abnormality of the astrocytes (HP:0100707)2.25479825
67Pachygyria (HP:0001302)2.24656206
68Abnormality of binocular vision (HP:0011514)2.18608705
69Diplopia (HP:0000651)2.18608705
70Vascular tortuosity (HP:0004948)2.18405050
71Inappropriate behavior (HP:0000719)2.17384167
72Renal cortical cysts (HP:0000803)2.15822740
73Congenital primary aphakia (HP:0007707)2.12807112
74Apathy (HP:0000741)2.11673270
75Intestinal atresia (HP:0011100)2.09979322
76Abnormal hair whorl (HP:0010721)2.09159333
77Protruding tongue (HP:0010808)2.07454214
78Retinal dysplasia (HP:0007973)2.07212173
79Keratoconus (HP:0000563)2.05903853
80Increased corneal curvature (HP:0100692)2.05903853
81Broad foot (HP:0001769)2.05832713
82Morphological abnormality of the inner ear (HP:0011390)2.04222193
83Aplasia/Hypoplasia of the tongue (HP:0010295)2.02579309
84Colon cancer (HP:0003003)2.02505947
85Neuronal loss in central nervous system (HP:0002529)2.02405250
86Corneal dystrophy (HP:0001131)2.01903601
87Large for gestational age (HP:0001520)2.01017879
88Chorioretinal atrophy (HP:0000533)2.00963458
89Absence seizures (HP:0002121)2.00658356
90Stereotypic behavior (HP:0000733)2.00476054
91Glioma (HP:0009733)1.99787927
92Gait imbalance (HP:0002141)1.98675836
93Absent speech (HP:0001344)1.98381428
94Split foot (HP:0001839)1.98322768
95Short foot (HP:0001773)1.97851214
96Occipital encephalocele (HP:0002085)1.97802520
97Polyphagia (HP:0002591)1.97783366
98Heterochromia iridis (HP:0001100)1.97277895
99Short tibia (HP:0005736)1.97135401
100Generalized myoclonic seizures (HP:0002123)1.96993167
101Optic nerve hypoplasia (HP:0000609)1.96647446
102Diminished motivation (HP:0000745)1.96083344
103Drooling (HP:0002307)1.95298391
104Excessive salivation (HP:0003781)1.95298391
105Neoplasm of the adrenal cortex (HP:0100641)1.93060857
106Urethral obstruction (HP:0000796)1.92469614
107Focal seizures (HP:0007359)1.92402622
108Attenuation of retinal blood vessels (HP:0007843)1.90995095
109Left ventricular hypertrophy (HP:0001712)1.90127320
110Oligodactyly (HP:0012165)1.89883325
111Epileptiform EEG discharges (HP:0011182)1.89261525
112Postaxial foot polydactyly (HP:0001830)1.88455176
113EEG with generalized epileptiform discharges (HP:0011198)1.87937806
114Fair hair (HP:0002286)1.87645617
115Aplasia/Hypoplasia of the lens (HP:0008063)1.87459813
116Agnosia (HP:0010524)1.87429776
117Abolished electroretinogram (ERG) (HP:0000550)1.87311809
118Cystic liver disease (HP:0006706)1.87286421
119Adactyly (HP:0009776)1.87199787
120Hemiparesis (HP:0001269)1.86320952
121Congenital sensorineural hearing impairment (HP:0008527)1.85762834
122Renal hypoplasia (HP:0000089)1.85369879
123Amblyopia (HP:0000646)1.85176609
124Abnormality of macular pigmentation (HP:0008002)1.84534402
125Ankle clonus (HP:0011448)1.83925881
126Agitation (HP:0000713)1.82603700
127Disinhibition (HP:0000734)1.82451124
128Hypoplastic iliac wings (HP:0002866)1.81320476
129Hypsarrhythmia (HP:0002521)1.81290814
130Blue irides (HP:0000635)1.80324491
131Narrow forehead (HP:0000341)1.80169320
132Hypothermia (HP:0002045)1.79927785
133Aplasia involving bones of the upper limbs (HP:0009823)1.79849796
134Aplasia of the phalanges of the hand (HP:0009802)1.79849796
135Aplasia involving bones of the extremities (HP:0009825)1.79849796
136Progressive macrocephaly (HP:0004481)1.79683526
137Abnormality of macrophages (HP:0004311)1.78967031
138Absent frontal sinuses (HP:0002688)1.77479712
139Specific learning disability (HP:0001328)1.77289048
140Myokymia (HP:0002411)1.77025790
141Thyroid carcinoma (HP:0002890)1.76835851
142Progressive hearing impairment (HP:0001730)1.76583082
143Papillary thyroid carcinoma (HP:0002895)1.74521350
144Gingivitis (HP:0000230)1.74230046
145Bile duct proliferation (HP:0001408)1.73978657
146Abnormal biliary tract physiology (HP:0012439)1.73978657
147Hematochezia (HP:0002573)1.73464648
148Inability to walk (HP:0002540)1.72838882
149Basal ganglia calcification (HP:0002135)1.72703431
150Retrobulbar optic neuritis (HP:0100654)1.72083951
151Optic neuritis (HP:0100653)1.72083951
152Dysdiadochokinesis (HP:0002075)1.70978922
153Akinesia (HP:0002304)1.70890028
154Tetraparesis (HP:0002273)1.70597402
155Abnormal drinking behavior (HP:0030082)1.70286626
156Polydipsia (HP:0001959)1.70286626
157Stomach cancer (HP:0012126)1.69407084
158Eosinophilia (HP:0001880)1.68040508
159Tubulointerstitial nephritis (HP:0001970)1.67747168
160Medial flaring of the eyebrow (HP:0010747)1.65591487
161Widely spaced teeth (HP:0000687)1.65363061
162Abnormal eating behavior (HP:0100738)1.64033278
163Nephrogenic diabetes insipidus (HP:0009806)1.63688245
164Progressive visual loss (HP:0000529)1.63432324
165Glomerulonephritis (HP:0000099)1.62553584
166Postural instability (HP:0002172)1.62035572
167Septo-optic dysplasia (HP:0100842)1.61901404
168Stomatitis (HP:0010280)1.61453977
169Broad ribs (HP:0000885)1.59094554
170Leiomyosarcoma (HP:0100243)1.58699103
171Uterine leiomyosarcoma (HP:0002891)1.58699103
172True hermaphroditism (HP:0010459)1.57976542
173Generalized tonic-clonic seizures (HP:0002069)1.57693446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.98829962
2MAP4K24.07394339
3WNK33.05176393
4NTRK22.61281150
5MAPK132.53382783
6NTRK32.52764593
7MARK12.36865554
8RIPK42.30912785
9BCR2.27896218
10PINK12.21997867
11CSNK1G22.13737896
12CSNK1G32.09695801
13CSNK1G12.06944510
14CAMK1G2.05916264
15CAMK1D2.03803622
16TAOK31.99561464
17CSNK1A1L1.90986560
18PAK31.89833169
19MAP2K71.89041620
20BMPR1B1.83493393
21PHKG21.74451994
22PHKG11.74451994
23SGK21.60219289
24MAP3K121.56381892
25MAPK151.56145949
26TRIM281.54369385
27MAP3K41.53716799
28SIK31.47317271
29GRK71.43118970
30DMPK1.37533292
31NUAK11.37407822
32KIT1.31286263
33TBK11.30889271
34FES1.30755362
35YES11.28699742
36INSRR1.28371968
37STK38L1.26517359
38IRAK11.26145338
39IRAK21.24118077
40PLK21.23407865
41BMPR21.23154246
42SIK21.22305554
43TGFBR21.17409699
44CAMKK21.17266462
45TYK21.15175480
46IRAK41.14776900
47SGK31.12975734
48TNIK1.10788521
49JAK31.10182805
50MAP3K141.09164389
51CCNB11.07734533
52STK391.07654435
53EPHA41.07461667
54CSF1R1.07157109
55FGR1.06841694
56FRK1.06172982
57FER1.05452005
58GRK11.05079027
59PDGFRA1.02080379
60SGK2231.02018333
61SGK4941.02018333
62JAK10.99106922
63ADRBK20.98999860
64MST40.98753689
65MAP3K90.97641919
66PNCK0.96005046
67FGFR20.95768961
68RET0.94996582
69CDK50.94361781
70PRKCE0.91385348
71LMTK20.90402776
72MINK10.89394380
73PRPF4B0.89223066
74EPHA30.89116080
75OBSCN0.88310088
76IRAK30.88059612
77MAP2K40.87096438
78MATK0.86838968
79ACVR1B0.86667902
80RPS6KA20.86460803
81EIF2AK20.84808194
82SGK10.83612557
83DYRK20.81286204
84PKN10.80811378
85CAMKK10.79949403
86KSR10.78141236
87PAK60.78024518
88UHMK10.71590890
89BMX0.69410725
90AKT30.69386673
91CHUK0.68679510
92CDK30.68425286
93SIK10.68264802
94ERBB40.66994635
95MUSK0.65826664
96PRKD30.65575080
97NTRK10.64167483
98CAMK2B0.63887007
99BCKDK0.63334607
100TSSK60.63261359
101BLK0.63183959
102DAPK20.62427811
103PDK20.61085396
104MKNK20.60286253
105STK240.59408686
106CSNK1D0.58776916
107ADRBK10.57946350
108DAPK10.56070140
109CAMK2D0.54677095
110DYRK1A0.54300383
111BRSK20.54122630
112TIE10.54049024
113PIK3CA0.53320288
114VRK10.52857113
115EIF2AK30.52303999
116PDGFRB0.51493032
117ROCK10.50809354
118JAK20.50569412
119PRKAA10.49756092
120CSNK1A10.49469905
121CAMK40.48424425
122PRKG10.47789240
123ERBB30.47293111
124PRKACA0.47042970
125PRKCG0.46774477
126LIMK10.45512348
127CAMK2A0.44668907
128NEK60.43629931
129WEE10.43392374
130LYN0.43263465
131WNK40.42738008
132PTK2B0.42735727
133HCK0.41748075
134PRKCZ0.41678830
135IKBKB0.40925745
136PRKACB0.40260953
137OXSR10.39084449
138IGF1R0.38987527
139SYK0.38689746
140FGFR30.36666005
141MKNK10.36544974
142IKBKE0.36180600
143STK30.36130224
144PRKCB0.35346723
145CAMK2G0.34187409
146CAMK10.34058015
147TGFBR10.33629108
148CSNK1E0.32990785
149RAF10.32255910
150ROCK20.31072813
151STK380.30796104
152ERBB20.30115325
153PRKDC0.29978565

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.37143642
2Butanoate metabolism_Homo sapiens_hsa006502.80488810
3Nicotine addiction_Homo sapiens_hsa050332.40491055
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.33342563
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.07942875
6Other glycan degradation_Homo sapiens_hsa005112.01018051
7Type I diabetes mellitus_Homo sapiens_hsa049401.99427061
8Phototransduction_Homo sapiens_hsa047441.89376311
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86824675
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83412051
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83130558
12Rheumatoid arthritis_Homo sapiens_hsa053231.82594623
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81464578
14Synaptic vesicle cycle_Homo sapiens_hsa047211.80295173
15African trypanosomiasis_Homo sapiens_hsa051431.76975460
16Steroid biosynthesis_Homo sapiens_hsa001001.74884950
17Protein export_Homo sapiens_hsa030601.70307155
18Leishmaniasis_Homo sapiens_hsa051401.69173029
19Propanoate metabolism_Homo sapiens_hsa006401.68786169
20Lysosome_Homo sapiens_hsa041421.60585250
21Fatty acid elongation_Homo sapiens_hsa000621.55510749
22Collecting duct acid secretion_Homo sapiens_hsa049661.52421965
23Morphine addiction_Homo sapiens_hsa050321.52285150
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.51049285
25Fatty acid metabolism_Homo sapiens_hsa012121.48636152
26Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.46878016
27GABAergic synapse_Homo sapiens_hsa047271.44973671
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43962852
29Osteoclast differentiation_Homo sapiens_hsa043801.43248530
30Tuberculosis_Homo sapiens_hsa051521.40060809
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.38556062
32Phagosome_Homo sapiens_hsa041451.38335401
33beta-Alanine metabolism_Homo sapiens_hsa004101.37746289
34Pertussis_Homo sapiens_hsa051331.34674753
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33785879
36Glutamatergic synapse_Homo sapiens_hsa047241.31959907
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26960846
38Allograft rejection_Homo sapiens_hsa053301.26355752
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25168081
40Regulation of autophagy_Homo sapiens_hsa041401.24612327
41Vibrio cholerae infection_Homo sapiens_hsa051101.21172792
42Graft-versus-host disease_Homo sapiens_hsa053321.19417265
43Olfactory transduction_Homo sapiens_hsa047401.18408372
44Nitrogen metabolism_Homo sapiens_hsa009101.16138416
45Influenza A_Homo sapiens_hsa051641.15778947
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.13161543
47Legionellosis_Homo sapiens_hsa051341.12616944
48Salmonella infection_Homo sapiens_hsa051321.12574059
49Chemokine signaling pathway_Homo sapiens_hsa040621.12003061
50Circadian entrainment_Homo sapiens_hsa047131.09298393
51Peroxisome_Homo sapiens_hsa041461.07360649
52Type II diabetes mellitus_Homo sapiens_hsa049301.07173891
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06406712
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03157814
55TNF signaling pathway_Homo sapiens_hsa046681.02959066
56Cocaine addiction_Homo sapiens_hsa050301.02587333
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02535559
58Cholinergic synapse_Homo sapiens_hsa047251.01862430
59Serotonergic synapse_Homo sapiens_hsa047261.00286148
60Fatty acid degradation_Homo sapiens_hsa000710.99397221
61Malaria_Homo sapiens_hsa051440.99270138
62Fatty acid biosynthesis_Homo sapiens_hsa000610.96615396
63Tryptophan metabolism_Homo sapiens_hsa003800.96430890
64Glioma_Homo sapiens_hsa052140.95996742
65Insulin secretion_Homo sapiens_hsa049110.95328651
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94563412
67ErbB signaling pathway_Homo sapiens_hsa040120.94367508
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93250021
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93151390
70B cell receptor signaling pathway_Homo sapiens_hsa046620.92960531
71Measles_Homo sapiens_hsa051620.91317975
72Linoleic acid metabolism_Homo sapiens_hsa005910.90741386
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89712226
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89663878
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89089132
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.88599277
77Prolactin signaling pathway_Homo sapiens_hsa049170.87364147
78Toxoplasmosis_Homo sapiens_hsa051450.86726282
79Ether lipid metabolism_Homo sapiens_hsa005650.86326334
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85737766
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85139622
82Long-term potentiation_Homo sapiens_hsa047200.84136468
83Dopaminergic synapse_Homo sapiens_hsa047280.83376802
84ABC transporters_Homo sapiens_hsa020100.82864337
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81893659
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.79836357
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79438162
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78632474
89Prion diseases_Homo sapiens_hsa050200.78565045
90Dorso-ventral axis formation_Homo sapiens_hsa043200.76663625
91Taste transduction_Homo sapiens_hsa047420.76541367
92Choline metabolism in cancer_Homo sapiens_hsa052310.76254664
93Renin secretion_Homo sapiens_hsa049240.75917321
94Salivary secretion_Homo sapiens_hsa049700.75683346
95Basal transcription factors_Homo sapiens_hsa030220.75388623
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75105706
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75004126
98Colorectal cancer_Homo sapiens_hsa052100.74973692
99Selenocompound metabolism_Homo sapiens_hsa004500.74520279
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74106498
101Cardiac muscle contraction_Homo sapiens_hsa042600.73668807
102Long-term depression_Homo sapiens_hsa047300.72669840
103Amphetamine addiction_Homo sapiens_hsa050310.72577907
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72535236
105Calcium signaling pathway_Homo sapiens_hsa040200.71612796
106Axon guidance_Homo sapiens_hsa043600.70786034
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70780468
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70739262
109Circadian rhythm_Homo sapiens_hsa047100.69868788
110Oxytocin signaling pathway_Homo sapiens_hsa049210.69800139
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69447655
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67813970
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.67266176
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67135268
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.66877143
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66640384
117Gap junction_Homo sapiens_hsa045400.65991937
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65664338
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65632130
120Asthma_Homo sapiens_hsa053100.65539976
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65327021
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64706032
123Estrogen signaling pathway_Homo sapiens_hsa049150.64150209
124Endometrial cancer_Homo sapiens_hsa052130.63935570
125Staphylococcus aureus infection_Homo sapiens_hsa051500.63517989
126Pancreatic cancer_Homo sapiens_hsa052120.62860951
127cAMP signaling pathway_Homo sapiens_hsa040240.62765797
128Gastric acid secretion_Homo sapiens_hsa049710.62252276
129Folate biosynthesis_Homo sapiens_hsa007900.61137162
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60693160
131Oxidative phosphorylation_Homo sapiens_hsa001900.60409077
132Histidine metabolism_Homo sapiens_hsa003400.59941706
133Amoebiasis_Homo sapiens_hsa051460.59776364
134Thyroid hormone synthesis_Homo sapiens_hsa049180.59623473
135Hepatitis B_Homo sapiens_hsa051610.58929345
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58650668
137MAPK signaling pathway_Homo sapiens_hsa040100.58413550
138Endocytosis_Homo sapiens_hsa041440.57568237
139Caffeine metabolism_Homo sapiens_hsa002320.57233297
140Dilated cardiomyopathy_Homo sapiens_hsa054140.57182888
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55824012
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55687027
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.55308478
144Hedgehog signaling pathway_Homo sapiens_hsa043400.55090970
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54503650
146Ovarian steroidogenesis_Homo sapiens_hsa049130.54407731
147Retinol metabolism_Homo sapiens_hsa008300.53855871
148Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53647694
149Hepatitis C_Homo sapiens_hsa051600.52781782
150Jak-STAT signaling pathway_Homo sapiens_hsa046300.52525957
151Hippo signaling pathway_Homo sapiens_hsa043900.52284297
152Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51967090
153Shigellosis_Homo sapiens_hsa051310.51769556
154Bile secretion_Homo sapiens_hsa049760.51704157
155GnRH signaling pathway_Homo sapiens_hsa049120.51685623
156PPAR signaling pathway_Homo sapiens_hsa033200.51669572
157Glycerolipid metabolism_Homo sapiens_hsa005610.51219075
158Pancreatic secretion_Homo sapiens_hsa049720.51067065
159Vitamin B6 metabolism_Homo sapiens_hsa007500.49844312
160Oocyte meiosis_Homo sapiens_hsa041140.48545808
161Chemical carcinogenesis_Homo sapiens_hsa052040.43140698
162Tight junction_Homo sapiens_hsa045300.40792841
163Arginine and proline metabolism_Homo sapiens_hsa003300.39143332
164Parkinsons disease_Homo sapiens_hsa050120.36886779

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