RNF181

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.14846214
2energy coupled proton transport, down electrochemical gradient (GO:0015985)7.54044860
3ATP synthesis coupled proton transport (GO:0015986)7.54044860
4viral transcription (GO:0019083)7.00726660
5translational termination (GO:0006415)6.65803830
6chaperone-mediated protein transport (GO:0072321)6.35898268
7ribosomal small subunit assembly (GO:0000028)6.24899409
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.20881640
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.19452794
10cotranslational protein targeting to membrane (GO:0006613)6.12714099
11protein targeting to ER (GO:0045047)6.09705063
12respiratory electron transport chain (GO:0022904)6.09009724
13electron transport chain (GO:0022900)5.96332420
14ribosomal small subunit biogenesis (GO:0042274)5.88247976
15L-phenylalanine catabolic process (GO:0006559)5.87619210
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.87619210
17establishment of protein localization to endoplasmic reticulum (GO:0072599)5.82036602
18protein localization to endoplasmic reticulum (GO:0070972)5.80963987
19translational elongation (GO:0006414)5.80176878
20L-phenylalanine metabolic process (GO:0006558)5.62639658
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.62639658
22establishment of protein localization to mitochondrial membrane (GO:0090151)5.61045588
23protein complex biogenesis (GO:0070271)5.49371439
24viral life cycle (GO:0019058)5.23597086
25maturation of SSU-rRNA (GO:0030490)5.16727993
26mitochondrial respiratory chain complex assembly (GO:0033108)5.10870341
27cellular protein complex disassembly (GO:0043624)5.05790702
28drug transmembrane transport (GO:0006855)4.96212814
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.92701334
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.88658384
31glyoxylate metabolic process (GO:0046487)4.88514192
32mitochondrial respiratory chain complex I assembly (GO:0032981)4.87178782
33NADH dehydrogenase complex assembly (GO:0010257)4.87178782
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.87178782
35translational initiation (GO:0006413)4.81495109
36cysteine metabolic process (GO:0006534)4.81266061
37aromatic amino acid family catabolic process (GO:0009074)4.60448905
38protein neddylation (GO:0045116)4.57765464
39ribosomal large subunit biogenesis (GO:0042273)4.53459123
40translation (GO:0006412)4.47216720
41ATP biosynthetic process (GO:0006754)4.38860811
42proteasome assembly (GO:0043248)4.36495111
43regulation of mitochondrial translation (GO:0070129)4.31165676
44protein complex disassembly (GO:0043241)4.28218266
45fatty acid elongation (GO:0030497)4.26394346
46drug transport (GO:0015893)4.20959019
47urate metabolic process (GO:0046415)4.20161958
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.18695285
49oxidative phosphorylation (GO:0006119)4.15626257
50protein targeting to membrane (GO:0006612)4.14433700
51purine nucleoside triphosphate biosynthetic process (GO:0009145)4.13912678
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.12067972
53hydrogen ion transmembrane transport (GO:1902600)4.11919034
54macromolecular complex disassembly (GO:0032984)4.09337134
55DNA deamination (GO:0045006)4.07651695
56serine family amino acid biosynthetic process (GO:0009070)4.04217219
57sulfur amino acid catabolic process (GO:0000098)4.03343103
58branched-chain amino acid catabolic process (GO:0009083)4.02428052
59regulation of cellular amino acid metabolic process (GO:0006521)3.97526499
60pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.92192740
61aldehyde catabolic process (GO:0046185)3.87990226
62lysine catabolic process (GO:0006554)3.87803037
63lysine metabolic process (GO:0006553)3.87803037
64branched-chain amino acid metabolic process (GO:0009081)3.87432668
65response to mercury ion (GO:0046689)3.86575319
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.86407028
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.86407028
68DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.85849303
69sequestering of actin monomers (GO:0042989)3.85574332
70protein targeting to mitochondrion (GO:0006626)3.83931646
71negative regulation of ligase activity (GO:0051352)3.83591476
72negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.83591476
73positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.82593458
74fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.78467999
75termination of RNA polymerase III transcription (GO:0006386)3.77119420
76transcription elongation from RNA polymerase III promoter (GO:0006385)3.77119420
77cytochrome complex assembly (GO:0017004)3.73728900
78cellular component biogenesis (GO:0044085)3.73637197
79signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.73498528
80signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.73498528
81signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.73498528
82intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.73156336
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.73156336
84serine family amino acid metabolic process (GO:0009069)3.71403995
85establishment of protein localization to mitochondrion (GO:0072655)3.68404276
86regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.67398672
87valine metabolic process (GO:0006573)3.67255614
88proton transport (GO:0015992)3.64625105
89tryptophan metabolic process (GO:0006568)3.63780769
90ribonucleoside triphosphate biosynthetic process (GO:0009201)3.63700611
91aromatic amino acid family metabolic process (GO:0009072)3.63657969
92glutathione derivative biosynthetic process (GO:1901687)3.63399636
93glutathione derivative metabolic process (GO:1901685)3.63399636
94signal transduction involved in DNA damage checkpoint (GO:0072422)3.61111986
95signal transduction involved in DNA integrity checkpoint (GO:0072401)3.61111986
96very long-chain fatty acid metabolic process (GO:0000038)3.60620807
97indole-containing compound catabolic process (GO:0042436)3.58151231
98indolalkylamine catabolic process (GO:0046218)3.58151231
99tryptophan catabolic process (GO:0006569)3.58151231
100nuclear-transcribed mRNA catabolic process (GO:0000956)3.58033770
101ethanol oxidation (GO:0006069)3.57486317
102aspartate family amino acid catabolic process (GO:0009068)3.57183679
103nonribosomal peptide biosynthetic process (GO:0019184)3.57109888
104alpha-linolenic acid metabolic process (GO:0036109)3.55841112
105bile acid biosynthetic process (GO:0006699)3.55624203
106signal transduction involved in cell cycle checkpoint (GO:0072395)3.55546243
107hydrogen transport (GO:0006818)3.55446224
108organic cation transport (GO:0015695)3.53615728
109short-chain fatty acid metabolic process (GO:0046459)3.52556674
110glutathione biosynthetic process (GO:0006750)3.52456618
111anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.51859441
112protein localization to mitochondrion (GO:0070585)3.47868028
113glutathione metabolic process (GO:0006749)3.46403635
114signal peptide processing (GO:0006465)3.45734977
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.45305710
116inner mitochondrial membrane organization (GO:0007007)3.44682196
117fatty acid beta-oxidation (GO:0006635)3.41691864
118L-serine metabolic process (GO:0006563)3.40997803
119nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37984037
120mRNA catabolic process (GO:0006402)3.37878870
121base-excision repair, AP site formation (GO:0006285)3.37159047
122cellular ketone body metabolic process (GO:0046950)3.36350757
123aminoglycoside antibiotic metabolic process (GO:0030647)3.35183063
124tyrosine metabolic process (GO:0006570)3.34618680
125serine family amino acid catabolic process (GO:0009071)3.33912361
126positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.33434778
127respiratory chain complex IV assembly (GO:0008535)3.31403188
128rRNA modification (GO:0000154)3.31029750
129nucleoside triphosphate biosynthetic process (GO:0009142)3.29146853
130GDP-mannose metabolic process (GO:0019673)3.28762557
131drug catabolic process (GO:0042737)3.28746924
132GTP biosynthetic process (GO:0006183)3.27223984
133ribonucleoprotein complex biogenesis (GO:0022613)3.27181253
134amino acid salvage (GO:0043102)3.26490948
135L-methionine salvage (GO:0071267)3.26490948
136L-methionine biosynthetic process (GO:0071265)3.26490948
137antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.25745373
138fatty acid catabolic process (GO:0009062)3.25639492
139coenzyme catabolic process (GO:0009109)3.24558036
140cellular amino acid catabolic process (GO:0009063)3.24124027
141amino-acid betaine metabolic process (GO:0006577)3.23683309
142fatty acid oxidation (GO:0019395)3.22781176
143alpha-amino acid catabolic process (GO:1901606)3.22463772
144exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21052852
145mitochondrial transport (GO:0006839)3.19094758
146positive regulation of ligase activity (GO:0051351)3.19069574
147lipid oxidation (GO:0034440)3.18375738
148pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.17946198
149pyrimidine nucleotide catabolic process (GO:0006244)3.17378503
150heme transport (GO:0015886)3.16593520
151deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.15222624
152pseudouridine synthesis (GO:0001522)3.13262907
153fructose metabolic process (GO:0006000)3.12943585
154L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.10895135
155carboxylic acid catabolic process (GO:0046395)3.09360631
156organic acid catabolic process (GO:0016054)3.09360631
157RNA catabolic process (GO:0006401)3.08997009
158cellular aldehyde metabolic process (GO:0006081)3.08479586
159purine nucleoside monophosphate biosynthetic process (GO:0009127)3.08111464
160purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.08111464
161tricarboxylic acid metabolic process (GO:0072350)3.06890637
162homocysteine metabolic process (GO:0050667)3.06266949
163cellular modified amino acid catabolic process (GO:0042219)3.03553781
164spliceosomal snRNP assembly (GO:0000387)3.02986617
165monocarboxylic acid catabolic process (GO:0072329)3.01421246
166establishment of protein localization to membrane (GO:0090150)3.01158090
167deoxyribonucleotide catabolic process (GO:0009264)3.01148527
168benzene-containing compound metabolic process (GO:0042537)2.99651210
169sulfur amino acid metabolic process (GO:0000096)2.97672461
170bile acid metabolic process (GO:0008206)2.97165174
171kynurenine metabolic process (GO:0070189)2.96889996
172thioester metabolic process (GO:0035383)2.95922660
173acyl-CoA metabolic process (GO:0006637)2.95922660
174regulation of cholesterol metabolic process (GO:0090181)2.95346358
175cofactor catabolic process (GO:0051187)2.95342514
176acetyl-CoA metabolic process (GO:0006084)2.95062074
177ketone body metabolic process (GO:1902224)2.93968006
178L-ascorbic acid metabolic process (GO:0019852)2.93311537
179response to lead ion (GO:0010288)2.91943564
180acyl-CoA biosynthetic process (GO:0071616)2.91939366
181thioester biosynthetic process (GO:0035384)2.91939366
182NADP metabolic process (GO:0006739)2.91852552
183response to misfolded protein (GO:0051788)2.91379281
184indolalkylamine metabolic process (GO:0006586)2.87735779
185sulfur amino acid biosynthetic process (GO:0000097)2.86013998
186response to nitrosative stress (GO:0051409)2.85572471
187proline metabolic process (GO:0006560)2.84017591
188ethanol metabolic process (GO:0006067)2.81857082
189peptide biosynthetic process (GO:0043043)2.81679809
190positive regulation of cellular amine metabolic process (GO:0033240)2.80661828
191fatty-acyl-CoA biosynthetic process (GO:0046949)2.79984959
192exogenous drug catabolic process (GO:0042738)2.78987637
193drug metabolic process (GO:0017144)2.78798099
194aspartate family amino acid metabolic process (GO:0009066)2.78365959
195long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.77937628
196glycine metabolic process (GO:0006544)2.77747592
197peptide catabolic process (GO:0043171)2.75441993
198axon ensheathment in central nervous system (GO:0032291)2.75070605
199central nervous system myelination (GO:0022010)2.75070605
200phosphate ion transport (GO:0006817)2.74912516

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.96964280
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.25380069
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.82454651
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.46302489
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.42661659
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.39035663
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.33083051
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11353656
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.04168767
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.97934822
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.94040259
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.81960076
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78812213
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.73036737
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.52484506
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.50186436
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49400815
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.23892056
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.23029914
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22193485
21ELK1_19687146_ChIP-ChIP_HELA_Human2.09532061
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01663148
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00177185
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.98608384
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96985203
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.93469029
27TTF2_22483619_ChIP-Seq_HELA_Human1.92465367
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83357594
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76570575
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73839977
31* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71038949
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64852135
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62893559
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61286940
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53294126
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48781375
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48552549
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45314295
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43244119
40* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39990992
41MYC_18940864_ChIP-ChIP_HL60_Human1.39783993
42* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38025899
43CLOCK_20551151_ChIP-Seq_293T_Human1.35874244
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30215820
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28704921
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27226918
47DCP1A_22483619_ChIP-Seq_HELA_Human1.26616009
48GABP_19822575_ChIP-Seq_HepG2_Human1.25845608
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.22800814
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20338801
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18990771
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17633130
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16223325
54VDR_23849224_ChIP-Seq_CD4+_Human1.14654797
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14016036
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13267233
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13197868
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12872753
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12104681
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11152213
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10640028
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09493848
63GATA4_25053715_ChIP-Seq_YYC3_Human1.08953153
64SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07235014
65KDM5A_27292631_Chip-Seq_BREAST_Human1.06115273
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04416471
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04302702
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03882196
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.03685385
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03365995
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03249009
72CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03111447
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02931423
74* FOXP1_21924763_ChIP-Seq_HESCs_Human1.02930068
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02233708
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01934308
77SOX17_20123909_ChIP-Seq_XEN_Mouse1.01675326
78* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01421968
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01247370
80* YY1_22570637_ChIP-Seq_MALME-3M_Human1.01236793
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01149822
82PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.00227622
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99406805
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99087398
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99060771
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98341673
87SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97450564
88KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97270047
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96685530
90NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95729481
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95297405
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94836139
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94240430
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94163170
95NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93910454
96ZNF263_19887448_ChIP-Seq_K562_Human0.93564955
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93511689
98BCL6_27268052_Chip-Seq_Bcells_Human0.93479295
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93159903
100FOXP3_21729870_ChIP-Seq_TREG_Human0.92714318
101ELF1_20517297_ChIP-Seq_JURKAT_Human0.92710326
102SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92689450
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92147996
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91875956
105* CTCF_26484167_Chip-Seq_Bcells_Mouse0.91867035
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90878841
107THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90051407
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89314388
109CTCF_20526341_ChIP-Seq_ESCs_Human0.88710779
110TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88318802
111XRN2_22483619_ChIP-Seq_HELA_Human0.88310463
112AR_20517297_ChIP-Seq_VCAP_Human0.87458429
113MYC_18555785_ChIP-Seq_MESCs_Mouse0.87031797
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86481133
115RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86117737
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85822659
117CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85727469
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85526358
119TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.85368724
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84973256
121ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84207786
122ERG_20517297_ChIP-Seq_VCAP_Human0.84134537
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83289042
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82577496
125* ELK1_22589737_ChIP-Seq_MCF10A_Human0.82479029
126EOMES_21245162_ChIP-Seq_HESCs_Human0.82120162
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81778489
128FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81658312
129TFEB_21752829_ChIP-Seq_HELA_Human0.81006976
130GATA1_22025678_ChIP-Seq_K562_Human0.80762797
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80626906
132FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80523691
133RARB_24833708_ChIP-Seq_LIVER_Mouse0.80282984
134OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79989298
135AR_21909140_ChIP-Seq_LNCAP_Human0.79838500
136MYC_19030024_ChIP-ChIP_MESCs_Mouse0.79566881
137MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79286355
138NANOG_18692474_ChIP-Seq_MEFs_Mouse0.79205918
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79119959
140PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79039783
141GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78662626
142ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.78577823
143HTT_18923047_ChIP-ChIP_STHdh_Human0.78232687
144* TET1_21451524_ChIP-Seq_MESCs_Mouse0.78108000
145SPI1_23547873_ChIP-Seq_NB4_Human0.75412693
146CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.74700494
147E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74261004

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.90734306
2MP0002139_abnormal_hepatobiliary_system5.74527837
3MP0005360_urolithiasis5.36849529
4MP0003806_abnormal_nucleotide_metabolis4.91887955
5MP0008875_abnormal_xenobiotic_pharmacok3.96088363
6MP0003195_calcinosis3.89195397
7MP0005365_abnormal_bile_salt3.87509222
8MP0005085_abnormal_gallbladder_physiolo3.56680261
9MP0005332_abnormal_amino_acid3.49143462
10MP0004043_abnormal_pH_regulation3.29206011
11MP0009840_abnormal_foam_cell3.09712408
12MP0003186_abnormal_redox_activity3.03946548
13MP0010030_abnormal_orbit_morphology3.01018708
14MP0005058_abnormal_lysosome_morphology2.83020101
15MP0004019_abnormal_vitamin_homeostasis2.79351553
16MP0006292_abnormal_olfactory_placode2.67743935
17MP0009643_abnormal_urine_homeostasis2.58237485
18MP0000372_irregular_coat_pigmentation2.36453385
19MP0002138_abnormal_hepatobiliary_system2.31743568
20MP0005083_abnormal_biliary_tract2.26588433
21MP0005636_abnormal_mineral_homeostasis2.24656681
22MP0001666_abnormal_nutrient_absorption2.22200358
23MP0002277_abnormal_respiratory_mucosa2.04520570
24MP0005671_abnormal_response_to2.02900598
25MP0003252_abnormal_bile_duct2.01872267
26MP0008789_abnormal_olfactory_epithelium1.98329949
27MP0010329_abnormal_lipoprotein_level1.96603692
28MP0001764_abnormal_homeostasis1.89722080
29MP0003191_abnormal_cellular_cholesterol1.84148630
30MP0001756_abnormal_urination1.81238229
31MP0006036_abnormal_mitochondrial_physio1.79028485
32MP0002148_abnormal_hypersensitivity_rea1.75678800
33MP0008058_abnormal_DNA_repair1.75444576
34MP0004957_abnormal_blastocyst_morpholog1.75057831
35MP0004147_increased_porphyrin_level1.74462435
36MP0005451_abnormal_body_composition1.73544077
37MP0009785_altered_susceptibility_to1.72307246
38MP0009333_abnormal_splenocyte_physiolog1.70414928
39MP0001765_abnormal_ion_homeostasis1.70224208
40MP0005584_abnormal_enzyme/coenzyme_acti1.68130279
41MP0003693_abnormal_embryo_hatching1.67833802
42MP0002118_abnormal_lipid_homeostasis1.67075963
43MP0001661_extended_life_span1.66416020
44MP0002938_white_spotting1.64517329
45MP0002234_abnormal_pharynx_morphology1.63822663
46MP0005319_abnormal_enzyme/_coenzyme1.61585381
47MP0003656_abnormal_erythrocyte_physiolo1.57247881
48MP0008932_abnormal_embryonic_tissue1.53623940
49MP0002837_dystrophic_cardiac_calcinosis1.51487944
50MP0006072_abnormal_retinal_apoptosis1.48300140
51MP0002653_abnormal_ependyma_morphology1.46340714
52MP0005408_hypopigmentation1.46323343
53MP0005410_abnormal_fertilization1.46268236
54MP0005084_abnormal_gallbladder_morpholo1.45454748
55MP0005499_abnormal_olfactory_system1.44858924
56MP0005394_taste/olfaction_phenotype1.44858924
57MP0001529_abnormal_vocalization1.43685423
58MP0000343_altered_response_to1.42971888
59MP0002638_abnormal_pupillary_reflex1.41858445
60MP0000609_abnormal_liver_physiology1.41141473
61MP0003329_amyloid_beta_deposits1.41098438
62MP0008260_abnormal_autophagy1.40669656
63MP0002136_abnormal_kidney_physiology1.39510552
64MP0005377_hearing/vestibular/ear_phenot1.36643397
65MP0003878_abnormal_ear_physiology1.36643397
66MP0001293_anophthalmia1.35920312
67MP0000920_abnormal_myelination1.28792916
68MP0003950_abnormal_plasma_membrane1.27292128
69MP0002163_abnormal_gland_morphology1.26940822
70MP0000049_abnormal_middle_ear1.24999085
71MP0004142_abnormal_muscle_tone1.21557486
72MP0004782_abnormal_surfactant_physiolog1.21444727
73MP0002876_abnormal_thyroid_physiology1.20387078
74MP0005075_abnormal_melanosome_morpholog1.15977433
75MP0005220_abnormal_exocrine_pancreas1.15698131
76MP0003718_maternal_effect1.15091830
77MP0003315_abnormal_perineum_morphology1.10262504
78MP0000639_abnormal_adrenal_gland1.09230707
79MP0003123_paternal_imprinting1.09183570
80MP0001958_emphysema1.08834412
81MP0005647_abnormal_sex_gland1.07379650
82MP0003011_delayed_dark_adaptation1.06866024
83MP0000604_amyloidosis1.06841248
84MP0002095_abnormal_skin_pigmentation1.06820729
85MP0001873_stomach_inflammation1.02499007
86MP0003646_muscle_fatigue0.98972709
87MP0005025_abnormal_response_to0.98027169
88MP0002295_abnormal_pulmonary_circulatio0.95342225
89MP0005395_other_phenotype0.95150668
90MP0010386_abnormal_urinary_bladder0.94394526
91MP0008469_abnormal_protein_level0.90254301
92MP0002736_abnormal_nociception_after0.89941863
93MP0004133_heterotaxia0.89264985
94MP0008007_abnormal_cellular_replicative0.88590242
95MP0000598_abnormal_liver_morphology0.88115582
96MP0001542_abnormal_bone_strength0.87423685
97MP0003077_abnormal_cell_cycle0.86251856
98MP0000230_abnormal_systemic_arterial0.85206863
99MP0001919_abnormal_reproductive_system0.85037468
100MP0001835_abnormal_antigen_presentation0.84527475
101MP0009642_abnormal_blood_homeostasis0.82575984
102MP0001845_abnormal_inflammatory_respons0.82212212
103MP0005376_homeostasis/metabolism_phenot0.81025049
104MP0003938_abnormal_ear_development0.80201966
105MP0001790_abnormal_immune_system0.80004165
106MP0005387_immune_system_phenotype0.80004165
107MP0006035_abnormal_mitochondrial_morpho0.79879318
108MP0003690_abnormal_glial_cell0.79820766
109MP0001485_abnormal_pinna_reflex0.79796657
110MP0000750_abnormal_muscle_regeneration0.79707219
111MP0002723_abnormal_immune_serum0.78072664
112MP0005389_reproductive_system_phenotype0.77203835
113MP0004264_abnormal_extraembryonic_tissu0.76007824
114MP0002210_abnormal_sex_determination0.75520345
115MP0008995_early_reproductive_senescence0.74952851
116MP0009765_abnormal_xenobiotic_induced0.74255303
117MP0001346_abnormal_lacrimal_gland0.73118127
118MP0005000_abnormal_immune_tolerance0.72762455
119MP0001905_abnormal_dopamine_level0.72684469
120MP0002282_abnormal_trachea_morphology0.72497196
121MP0004885_abnormal_endolymph0.72490363
122MP0004742_abnormal_vestibular_system0.72390885
123MP0002160_abnormal_reproductive_system0.72363435
124MP0003638_abnormal_response/metabolism_0.71866427
125MP0004145_abnormal_muscle_electrophysio0.70798238
126MP0002168_other_aberrant_phenotype0.70040750
127MP0003786_premature_aging0.69799299
128MP0005670_abnormal_white_adipose0.67835536
129MP0001881_abnormal_mammary_gland0.66712710
130MP0002132_abnormal_respiratory_system0.66391104
131MP0008872_abnormal_physiological_respon0.66314962
132MP0003075_altered_response_to0.66198505
133MP0005464_abnormal_platelet_physiology0.66066774
134MP0009764_decreased_sensitivity_to0.66052843
135MP0001819_abnormal_immune_cell0.65643171
136MP0002420_abnormal_adaptive_immunity0.65290624
137MP0000538_abnormal_urinary_bladder0.64295770
138MP0002078_abnormal_glucose_homeostasis0.64094018
139MP0003172_abnormal_lysosome_physiology0.63781938
140MP0003868_abnormal_feces_composition0.62971905
141MP0005266_abnormal_metabolism0.60798712
142MP0009384_cardiac_valve_regurgitation0.59075800
143MP0009697_abnormal_copulation0.57666916
144MP0006054_spinal_hemorrhage0.56279732
145MP0003953_abnormal_hormone_level0.55870804
146MP0002135_abnormal_kidney_morphology0.55679682
147MP0002254_reproductive_system_inflammat0.55437478
148MP0000358_abnormal_cell_content/0.54538096
149MP0005535_abnormal_body_temperature0.54067199
150MP0002796_impaired_skin_barrier0.52475200
151MP0002229_neurodegeneration0.50899303
152MP0001929_abnormal_gametogenesis0.50440699
153MP0009763_increased_sensitivity_to0.49473903
154MP0006082_CNS_inflammation0.49376343
155MP0001853_heart_inflammation0.48903953
156MP0003634_abnormal_glial_cell0.46583743
157MP0005310_abnormal_salivary_gland0.45388337
158MP0001727_abnormal_embryo_implantation0.41521711
159MP0005501_abnormal_skin_physiology0.41282530
160MP0001944_abnormal_pancreas_morphology0.41158456
161MP0000747_muscle_weakness0.40652850
162MP0005379_endocrine/exocrine_gland_phen0.40449455
163MP0001145_abnormal_male_reproductive0.39286405

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)5.48432450
2Lipid accumulation in hepatocytes (HP:0006561)5.11705926
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.99570794
4Abnormality of cells of the erythroid lineage (HP:0012130)4.52421903
5Gout (HP:0001997)4.38040948
6Reticulocytopenia (HP:0001896)4.29435503
7Abnormal number of erythroid precursors (HP:0012131)4.24525217
8Generalized aminoaciduria (HP:0002909)3.98152676
9Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.97829360
10Exertional dyspnea (HP:0002875)3.83258770
11Macrocytic anemia (HP:0001972)3.78335349
12Hyperglycinuria (HP:0003108)3.64495013
13Abnormality of glycine metabolism (HP:0010895)3.63687838
14Abnormality of serine family amino acid metabolism (HP:0010894)3.63687838
15Intrahepatic cholestasis (HP:0001406)3.61418390
16Increased serum lactate (HP:0002151)3.55376041
17Abnormality of fatty-acid metabolism (HP:0004359)3.53976042
18Proximal tubulopathy (HP:0000114)3.43341209
19Exercise intolerance (HP:0003546)3.38217824
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.27917847
21Renal salt wasting (HP:0000127)3.25897591
22Abnormality of glycolysis (HP:0004366)3.21445049
23Increased serum pyruvate (HP:0003542)3.21445049
24Glycosuria (HP:0003076)3.20999608
25Abnormality of urine glucose concentration (HP:0011016)3.20999608
26Hypokalemic alkalosis (HP:0001949)3.20927905
27Abnormality of dicarboxylic acid metabolism (HP:0010995)3.20368523
28Dicarboxylic aciduria (HP:0003215)3.20368523
29Ketosis (HP:0001946)3.19314486
30Hyperglycinemia (HP:0002154)3.19088724
31Aplasia/Hypoplasia of the sacrum (HP:0008517)3.14428015
32Respiratory difficulties (HP:0002880)3.14314375
33Hypoglycemic coma (HP:0001325)3.11055022
34Hepatic necrosis (HP:0002605)3.04642446
35Xanthomatosis (HP:0000991)3.04085305
36Vacuolated lymphocytes (HP:0001922)3.03913537
37Hyperammonemia (HP:0001987)3.03636818
38Increased circulating renin level (HP:0000848)3.01574905
39Aplastic anemia (HP:0001915)2.98227713
40Abnormality of glutamine family amino acid metabolism (HP:0010902)2.98082286
41Abnormality of purine metabolism (HP:0004352)2.95500547
42Increased purine levels (HP:0004368)2.92055796
43Hyperuricemia (HP:0002149)2.92055796
44Ketoacidosis (HP:0001993)2.88748147
45Abnormality of monocarboxylic acid metabolism (HP:0010996)2.88540686
46Lethargy (HP:0001254)2.88025914
47Hyperactive renin-angiotensin system (HP:0000841)2.85613314
48Acute encephalopathy (HP:0006846)2.85503471
49Optic disc pallor (HP:0000543)2.85261933
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.82336292
51Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.76920009
52Hypomagnesemia (HP:0002917)2.76692587
53Pallor (HP:0000980)2.75077405
54Alkalosis (HP:0001948)2.70572038
55Type I transferrin isoform profile (HP:0003642)2.64003115
56Cerebral edema (HP:0002181)2.62988838
57Methylmalonic aciduria (HP:0012120)2.62802745
58Leukodystrophy (HP:0002415)2.61601348
59Hyperlipoproteinemia (HP:0010980)2.61432473
60Abnormality of renal excretion (HP:0011036)2.60599540
61Delayed CNS myelination (HP:0002188)2.59850661
62Hepatocellular necrosis (HP:0001404)2.58514095
63Polyuria (HP:0000103)2.56418961
64Abnormal urine output (HP:0012590)2.55265675
65Metabolic acidosis (HP:0001942)2.54840828
66Fat malabsorption (HP:0002630)2.54387818
67Abnormality of sulfur amino acid metabolism (HP:0004339)2.51392408
68Abnormality of chloride homeostasis (HP:0011422)2.50614412
69Abnormality of magnesium homeostasis (HP:0004921)2.50553145
70Hypobetalipoproteinemia (HP:0003563)2.46466485
71Abnormal mitochondria in muscle tissue (HP:0008316)2.44879077
72Hyperaldosteronism (HP:0000859)2.44535655
73Emotional lability (HP:0000712)2.43528978
74Hyperphosphaturia (HP:0003109)2.42240667
75Acute necrotizing encephalopathy (HP:0006965)2.42083355
76Vomiting (HP:0002013)2.41315418
77Abnormality of serum amino acid levels (HP:0003112)2.39141051
78Metabolic alkalosis (HP:0200114)2.37804722
79Mitochondrial inheritance (HP:0001427)2.36017364
80Hypoplasia of the uterus (HP:0000013)2.35369889
81Prolonged neonatal jaundice (HP:0006579)2.34307579
82Abnormality of nucleobase metabolism (HP:0010932)2.33509060
83Abnormality of renin-angiotensin system (HP:0000847)2.32532947
84Steatorrhea (HP:0002570)2.31972160
85Irritability (HP:0000737)2.29963802
86Deep venous thrombosis (HP:0002625)2.28713710
87Decreased activity of mitochondrial respiratory chain (HP:0008972)2.28303125
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.28303125
893-Methylglutaconic aciduria (HP:0003535)2.24164075
90Abnormality of renal resorption (HP:0011038)2.23773137
91Neurofibrillary tangles (HP:0002185)2.21745404
92Malnutrition (HP:0004395)2.20491218
93Abnormal protein glycosylation (HP:0012346)2.19785495
94Abnormal glycosylation (HP:0012345)2.19785495
95Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.19785495
96Abnormal protein N-linked glycosylation (HP:0012347)2.19785495
97Abnormality of methionine metabolism (HP:0010901)2.19173389
98Spastic paraparesis (HP:0002313)2.19079740
99Oral leukoplakia (HP:0002745)2.18684478
100Lactic acidosis (HP:0003128)2.16370064
101Opisthotonus (HP:0002179)2.15041783
102Polydipsia (HP:0001959)2.14938598
103Abnormal drinking behavior (HP:0030082)2.14938598
104Pancytopenia (HP:0001876)2.14017958
105CNS demyelination (HP:0007305)2.13636887
106Renal Fanconi syndrome (HP:0001994)2.13385896
107Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.12844249
108X-linked dominant inheritance (HP:0001423)2.12354752
109Increased CSF lactate (HP:0002490)2.12157639
110Increased muscle lipid content (HP:0009058)2.11440777
111Congenital, generalized hypertrichosis (HP:0004540)2.09131297
112Vascular calcification (HP:0004934)2.08269367
113Colon cancer (HP:0003003)2.07089511
114Brushfield spots (HP:0001088)2.06284715
115Prolonged partial thromboplastin time (HP:0003645)2.04584970
116Nausea (HP:0002018)2.03363668
117Abnormal urine phosphate concentration (HP:0012599)2.03299653
118Muscle fiber atrophy (HP:0100295)2.02652228
119Rickets (HP:0002748)1.98384980
120Respiratory failure (HP:0002878)1.98092330
121Abnormality of the intrinsic pathway (HP:0010989)1.96845367
122Conjugated hyperbilirubinemia (HP:0002908)1.95146432
123Type 2 muscle fiber atrophy (HP:0003554)1.95019520
124Abnormal enzyme/coenzyme activity (HP:0012379)1.94771269
125Progressive macrocephaly (HP:0004481)1.92326162
126Microvesicular hepatic steatosis (HP:0001414)1.92036857
127Hyperbilirubinemia (HP:0002904)1.91726851
128Abnormality of midbrain morphology (HP:0002418)1.91450772
129Molar tooth sign on MRI (HP:0002419)1.91450772
130Respiratory distress (HP:0002098)1.90466232
131Epiphyseal stippling (HP:0010655)1.90296166
132Absent thumb (HP:0009777)1.90250353
133Increased intramyocellular lipid droplets (HP:0012240)1.90214599
134Rough bone trabeculation (HP:0100670)1.88781367
135Progressive neurologic deterioration (HP:0002344)1.88658572
136Hydroxyprolinuria (HP:0003080)1.88392097
137Sclerocornea (HP:0000647)1.86892144
138Renal tubular dysfunction (HP:0000124)1.86302630
139Microretrognathia (HP:0000308)1.85057635
140Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84601132
141Methylmalonic acidemia (HP:0002912)1.82136725
142Cleft eyelid (HP:0000625)1.79544195
143Sparse eyelashes (HP:0000653)1.79493022
144Gliosis (HP:0002171)1.78265741
145Blindness (HP:0000618)1.77258665
146Degeneration of anterior horn cells (HP:0002398)1.76178529
147Abnormality of the anterior horn cell (HP:0006802)1.76178529
148Pancreatic cysts (HP:0001737)1.75132424
149Abnormality of placental membranes (HP:0011409)1.74243590
150Amniotic constriction ring (HP:0009775)1.74243590
151Stenosis of the external auditory canal (HP:0000402)1.71263901
152Pancreatic fibrosis (HP:0100732)1.67622775
153Congenital ichthyosiform erythroderma (HP:0007431)1.64109883
154Myokymia (HP:0002411)1.59946604
155Hypoplastic left heart (HP:0004383)1.56639966
156IgM deficiency (HP:0002850)1.53451255
157Neutropenia (HP:0001875)1.51715155
158Cellular immunodeficiency (HP:0005374)1.47934148
159Reduced antithrombin III activity (HP:0001976)1.47037509
160Abnormal trabecular bone morphology (HP:0100671)1.46168518
161Medial flaring of the eyebrow (HP:0010747)1.45241257
162Abnormal rod and cone electroretinograms (HP:0008323)1.44261971
163Aplasia/hypoplasia of the uterus (HP:0008684)1.43660010
164Parakeratosis (HP:0001036)1.42558764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK27.34642740
2BCKDK4.68119213
3WNK44.57781179
4STK393.93922827
5OXSR13.91623105
6STK162.77843149
7WNK32.58878529
8EPHA22.45284675
9ZAK2.44408066
10MST42.40238126
11TAF12.36182838
12NUAK12.33064053
13TLK12.19190676
14BUB12.17350871
15MET2.06287606
16PDK31.93985886
17PDK41.93985886
18SRPK11.93035906
19MYLK1.93017122
20TESK21.91496804
21PBK1.84592105
22ARAF1.84248447
23EPHB11.78556311
24ERN11.78052385
25EIF2AK11.72211569
26TESK11.57188437
27CDC71.56195167
28STK38L1.52509794
29MAP4K21.50203758
30CDK81.48428885
31PDK21.45309472
32MAPKAPK51.45250300
33EIF2AK31.39133761
34BRAF1.37889387
35TXK1.36635936
36LIMK11.33110945
37PINK11.31073793
38NME21.30122252
39MST1R1.29956513
40WEE11.27467711
41PIM21.25030690
42FLT31.17652377
43LRRK21.13819574
44MAPK151.12520750
45AKT31.10150093
46TAOK31.08033257
47ADRBK21.07612168
48MAP2K21.06497731
49BCR1.04734505
50PIK3CG1.04678190
51SGK4940.99845273
52SGK2230.99845273
53IRAK30.98974515
54CDK190.98381243
55DAPK10.97395073
56FGFR20.97380059
57CSNK1G30.94571759
58ABL20.92938263
59FGFR40.92263260
60PLK30.89176621
61DYRK30.87699636
62PLK40.87102883
63PRKD30.85412370
64WNK10.84872017
65KDR0.83429073
66MAP3K120.80772958
67GRK70.80191171
68TRIM280.78472420
69EPHB20.75841110
70DYRK1B0.75785080
71GRK50.74799774
72IKBKB0.74403128
73AURKB0.73189698
74BMPR1B0.72399494
75PAK40.71814134
76DYRK20.70210485
77GRK10.66634781
78CSNK2A20.66157553
79BRSK20.65855592
80SMG10.65770475
81CSNK2A10.63230131
82FRK0.62454295
83MAP2K70.62027179
84NEK10.61536402
85CAMK2G0.61524552
86MAP3K20.60793410
87CSNK1G10.60437096
88IRAK20.58856053
89ZAP700.58746346
90PLK10.54383494
91ERBB40.53926212
92CSNK1A1L0.52337192
93NME10.50841236
94TBK10.49220629
95TYK20.48184502
96PASK0.47550879
97CHEK20.47366788
98PAK10.46575229
99PRKCI0.46396976
100CDK90.45754132
101RPS6KB20.45670870
102INSRR0.45387338
103STK100.44796537
104MAPKAPK30.43410345
105CDK70.42994130
106MUSK0.42293805
107IRAK10.42266492
108CSNK1G20.40986209
109MAP3K30.38837414
110MAP3K110.38705908
111AURKA0.38686669
112STK40.38196091
113MAP2K60.37617029
114DAPK30.37211991
115RPS6KA50.37055865
116CAMK2B0.35555829
117VRK10.35328554
118CAMK2D0.35003050
119CCNB10.34862234
120ROCK20.34176482
121NEK90.34027768
122MAP4K10.33011701
123PRKCD0.32470553
124TIE10.32291444
125MAP2K10.32028454
126IKBKE0.31780151
127TTK0.31493727
128ADRBK10.30980101
129PTK20.30867477
130ILK0.30730412
131ATR0.30424964
132MAP3K80.30122999
133PRKCQ0.29658444
134SIK10.29274322
135BRSK10.28760086
136CSNK1A10.28141214
137NEK60.28004318
138SCYL20.27232229
139NTRK10.27039274
140GSK3A0.25685237
141TGFBR10.25531451
142MOS0.25504358
143TAOK20.25108091
144CDK11A0.24984627
145CDK140.23947624
146KSR20.23503142
147EIF2AK20.20627314

Predicted pathways (KEGG)

RankGene SetZ-score
1Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.68030808
2Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55438107
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50770491
4Fatty acid elongation_Homo sapiens_hsa000622.47772518
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45251276
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.43428028
7Propanoate metabolism_Homo sapiens_hsa006402.37780815
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.25221403
9Sulfur metabolism_Homo sapiens_hsa009202.21704422
10Peroxisome_Homo sapiens_hsa041462.18802433
11Protein export_Homo sapiens_hsa030602.18120861
12Butanoate metabolism_Homo sapiens_hsa006502.17527644
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.16895548
14Cardiac muscle contraction_Homo sapiens_hsa042602.14423386
15Fatty acid degradation_Homo sapiens_hsa000712.13660869
16DNA replication_Homo sapiens_hsa030302.09813085
17Folate biosynthesis_Homo sapiens_hsa007902.08560228
18Mismatch repair_Homo sapiens_hsa034302.04688674
19Pyruvate metabolism_Homo sapiens_hsa006202.04346260
20Histidine metabolism_Homo sapiens_hsa003401.98980294
21Tryptophan metabolism_Homo sapiens_hsa003801.98765293
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96378002
23Steroid biosynthesis_Homo sapiens_hsa001001.94801180
24Vitamin B6 metabolism_Homo sapiens_hsa007501.88948575
25Homologous recombination_Homo sapiens_hsa034401.82927800
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.82180395
27Fatty acid metabolism_Homo sapiens_hsa012121.81070698
28Glutathione metabolism_Homo sapiens_hsa004801.72215133
29Proteasome_Homo sapiens_hsa030501.71150777
30Oxidative phosphorylation_Homo sapiens_hsa001901.70255530
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66524691
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65179077
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60554414
34Base excision repair_Homo sapiens_hsa034101.58823815
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55561952
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.53813607
37Vitamin digestion and absorption_Homo sapiens_hsa049771.51651552
38Nucleotide excision repair_Homo sapiens_hsa034201.51350647
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49360644
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.47144120
41Chemical carcinogenesis_Homo sapiens_hsa052041.46414974
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46266060
43Carbon metabolism_Homo sapiens_hsa012001.43112296
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.42080819
45beta-Alanine metabolism_Homo sapiens_hsa004101.41506001
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.40913944
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35698667
48Arginine and proline metabolism_Homo sapiens_hsa003301.34562070
49Spliceosome_Homo sapiens_hsa030401.27836509
50Selenocompound metabolism_Homo sapiens_hsa004501.24947254
51Parkinsons disease_Homo sapiens_hsa050121.24795220
52Nitrogen metabolism_Homo sapiens_hsa009101.21947063
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20286470
54Biosynthesis of amino acids_Homo sapiens_hsa012301.19242028
55PPAR signaling pathway_Homo sapiens_hsa033201.16431924
56Pentose phosphate pathway_Homo sapiens_hsa000301.16208964
57Arginine biosynthesis_Homo sapiens_hsa002201.15039986
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.14948239
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13530505
60Tyrosine metabolism_Homo sapiens_hsa003501.11705772
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10521588
62Retinol metabolism_Homo sapiens_hsa008301.08918752
63Collecting duct acid secretion_Homo sapiens_hsa049661.08754586
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06026604
65Phenylalanine metabolism_Homo sapiens_hsa003601.05622236
66Regulation of autophagy_Homo sapiens_hsa041401.01431701
67One carbon pool by folate_Homo sapiens_hsa006701.01086082
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00461152
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96406472
70Other glycan degradation_Homo sapiens_hsa005110.95246194
71Metabolic pathways_Homo sapiens_hsa011000.93744752
72Complement and coagulation cascades_Homo sapiens_hsa046100.92661712
73Fanconi anemia pathway_Homo sapiens_hsa034600.92651452
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92591649
75Lysosome_Homo sapiens_hsa041420.92261387
76Sulfur relay system_Homo sapiens_hsa041220.91009802
77RNA degradation_Homo sapiens_hsa030180.89651934
78Asthma_Homo sapiens_hsa053100.88515178
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88040471
80Fat digestion and absorption_Homo sapiens_hsa049750.87630033
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87349618
82Primary immunodeficiency_Homo sapiens_hsa053400.85389203
83Fructose and mannose metabolism_Homo sapiens_hsa000510.85361154
84Linoleic acid metabolism_Homo sapiens_hsa005910.82237209
85Graft-versus-host disease_Homo sapiens_hsa053320.81361500
86Systemic lupus erythematosus_Homo sapiens_hsa053220.80279612
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79626638
88RNA polymerase_Homo sapiens_hsa030200.79436089
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79285399
90Autoimmune thyroid disease_Homo sapiens_hsa053200.77043008
91Allograft rejection_Homo sapiens_hsa053300.76493392
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75787867
93Glycerolipid metabolism_Homo sapiens_hsa005610.75715472
94Antigen processing and presentation_Homo sapiens_hsa046120.73718140
95Starch and sucrose metabolism_Homo sapiens_hsa005000.72072907
96Bile secretion_Homo sapiens_hsa049760.70421260
97Ether lipid metabolism_Homo sapiens_hsa005650.70381589
98Caffeine metabolism_Homo sapiens_hsa002320.69999675
99Alzheimers disease_Homo sapiens_hsa050100.69671071
100Huntingtons disease_Homo sapiens_hsa050160.69537487
101Vibrio cholerae infection_Homo sapiens_hsa051100.68671921
102Arachidonic acid metabolism_Homo sapiens_hsa005900.68090695
103Sphingolipid metabolism_Homo sapiens_hsa006000.67976311
104RNA transport_Homo sapiens_hsa030130.66879056
105Mineral absorption_Homo sapiens_hsa049780.62110528
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58906369
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.58248056
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55307253
109Ribosome_Homo sapiens_hsa030100.48144813
110Pyrimidine metabolism_Homo sapiens_hsa002400.47674645
111ABC transporters_Homo sapiens_hsa020100.46268282
112Type I diabetes mellitus_Homo sapiens_hsa049400.44917839
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44068708
114Epstein-Barr virus infection_Homo sapiens_hsa051690.37477712
115Galactose metabolism_Homo sapiens_hsa000520.35931296
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.34097197
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29168534
118N-Glycan biosynthesis_Homo sapiens_hsa005100.28281868
119Renin-angiotensin system_Homo sapiens_hsa046140.27597579
120Purine metabolism_Homo sapiens_hsa002300.25143392
121p53 signaling pathway_Homo sapiens_hsa041150.25138045
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24003816
123Hematopoietic cell lineage_Homo sapiens_hsa046400.23225367
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22989450
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.22573762
126Basal transcription factors_Homo sapiens_hsa030220.17185311
127Fatty acid biosynthesis_Homo sapiens_hsa000610.14512684
128Phagosome_Homo sapiens_hsa041450.13535629
129Rheumatoid arthritis_Homo sapiens_hsa053230.10273927

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