RNF183

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)8.69187860
2renal absorption (GO:0070293)7.02093561
3regulation of dendritic cell antigen processing and presentation (GO:0002604)6.47439462
4positive regulation of receptor biosynthetic process (GO:0010870)6.27657994
5drug transmembrane transport (GO:0006855)6.03069318
6urate metabolic process (GO:0046415)5.89100962
7regulation of lipoprotein particle clearance (GO:0010984)5.68483981
8peptide catabolic process (GO:0043171)5.66131102
9sensory perception of smell (GO:0007608)5.62987614
10imidazole-containing compound metabolic process (GO:0052803)5.59885119
11high-density lipoprotein particle remodeling (GO:0034375)5.48867548
12cell wall macromolecule catabolic process (GO:0016998)5.29260482
13aminoglycoside antibiotic metabolic process (GO:0030647)5.19722576
14positive regulation of Cdc42 GTPase activity (GO:0043089)5.09836650
15nitric oxide mediated signal transduction (GO:0007263)4.92931422
16drug transport (GO:0015893)4.86794797
17reverse cholesterol transport (GO:0043691)4.86457164
18nonribosomal peptide biosynthetic process (GO:0019184)4.77203983
19phosphate ion transport (GO:0006817)4.73994804
20hydrogen peroxide catabolic process (GO:0042744)4.67422682
21phospholipid efflux (GO:0033700)4.65174655
22regulation of cholesterol esterification (GO:0010872)4.62696646
23glutathione biosynthetic process (GO:0006750)4.59422190
24calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.57360080
25protein-lipid complex assembly (GO:0065005)4.49910676
26cell wall macromolecule metabolic process (GO:0044036)4.47105452
27cholesterol efflux (GO:0033344)4.44526659
28organic cation transport (GO:0015695)4.43220638
29plasma lipoprotein particle assembly (GO:0034377)4.39732804
30nephron tubule morphogenesis (GO:0072078)4.39193143
31nephron epithelium morphogenesis (GO:0072088)4.39193143
32positive regulation of antigen processing and presentation (GO:0002579)4.32962462
33regulation of T-helper 1 cell differentiation (GO:0045625)4.30506723
34nephron tubule formation (GO:0072079)4.23427612
35negative regulation of sterol transport (GO:0032372)4.15913464
36negative regulation of cholesterol transport (GO:0032375)4.15913464
37regulation of RIG-I signaling pathway (GO:0039535)4.11153518
38positive regulation of tolerance induction (GO:0002645)4.01689176
39response to lipoprotein particle (GO:0055094)4.01547857
40lysine catabolic process (GO:0006554)3.95775389
41lysine metabolic process (GO:0006553)3.95775389
42positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.94025953
43excretion (GO:0007588)3.90704967
44response to mercury ion (GO:0046689)3.88342776
45biotin metabolic process (GO:0006768)3.87426383
46positive regulation of granulocyte chemotaxis (GO:0071624)3.86918505
47regulation of receptor biosynthetic process (GO:0010869)3.83967279
48myeloid dendritic cell differentiation (GO:0043011)3.81307990
49NIK/NF-kappaB signaling (GO:0038061)3.78565396
50phosphatidylcholine biosynthetic process (GO:0006656)3.78067168
51regulation of regulatory T cell differentiation (GO:0045589)3.77023518
52protein-lipid complex remodeling (GO:0034368)3.72861807
53macromolecular complex remodeling (GO:0034367)3.72861807
54plasma lipoprotein particle remodeling (GO:0034369)3.72861807
55piRNA metabolic process (GO:0034587)3.72413666
56neurotransmitter catabolic process (GO:0042135)3.71149985
57positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.67755588
58negative regulation of lipase activity (GO:0060192)3.67591636
59intestinal cholesterol absorption (GO:0030299)3.66898503
60superoxide anion generation (GO:0042554)3.65866774
61regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.65838621
62ovulation from ovarian follicle (GO:0001542)3.65727580
63regulation of cytokine secretion involved in immune response (GO:0002739)3.62562489
64positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.61828124
65triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.60793787
66peptide biosynthetic process (GO:0043043)3.55996082
67axoneme assembly (GO:0035082)3.55357936
68keratinocyte development (GO:0003334)3.50222810
69macroautophagy (GO:0016236)3.49681103
70dendritic cell differentiation (GO:0097028)3.48045114
71negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.47450386
72negative regulation of interleukin-10 production (GO:0032693)3.38882138
73phosphate ion homeostasis (GO:0055062)3.38843744
74trivalent inorganic anion homeostasis (GO:0072506)3.38843744
75diterpenoid biosynthetic process (GO:0016102)3.38843493
76endocrine pancreas development (GO:0031018)3.38157252
77regulation of antigen processing and presentation (GO:0002577)3.37876836
78protein localization to cilium (GO:0061512)3.36709541
79regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.35962025
80lung vasculature development (GO:0060426)3.35440329
81pericardium development (GO:0060039)3.35046400
82phosphate ion transmembrane transport (GO:0035435)3.33987536
83positive regulation of glycoprotein biosynthetic process (GO:0010560)3.33055186
84magnesium ion transport (GO:0015693)3.30139011
85renal tubule morphogenesis (GO:0061333)3.26988909
86response to thyroid hormone (GO:0097066)3.26026744
87mitochondrial calcium ion transport (GO:0006851)3.26013782
88glyoxylate metabolic process (GO:0046487)3.25035814
89sodium-independent organic anion transport (GO:0043252)3.24890725
90regulation of glucokinase activity (GO:0033131)3.24846944
91regulation of hexokinase activity (GO:1903299)3.24846944
92positive regulation of DNA-templated transcription, initiation (GO:2000144)3.22419519
93embryonic heart tube development (GO:0035050)3.20294777
94vitamin transmembrane transport (GO:0035461)3.19140218
95response to nitric oxide (GO:0071731)3.19134803
96tongue development (GO:0043586)3.18764750
97quaternary ammonium group transport (GO:0015697)3.18004610
98cilium or flagellum-dependent cell motility (GO:0001539)3.17880025
99branched-chain amino acid metabolic process (GO:0009081)3.17257070
100sensory perception of chemical stimulus (GO:0007606)3.17082240
101myelin maintenance (GO:0043217)3.16253162
102nucleoside diphosphate catabolic process (GO:0009134)3.14812438
103plasma lipoprotein particle clearance (GO:0034381)3.14139641
104very-low-density lipoprotein particle assembly (GO:0034379)3.13154582
105positive regulation of glycoprotein metabolic process (GO:1903020)3.12301742
106tricarboxylic acid metabolic process (GO:0072350)3.12270330
107cellular response to hepatocyte growth factor stimulus (GO:0035729)3.11963324
108response to hepatocyte growth factor (GO:0035728)3.11963324
109chemosensory behavior (GO:0007635)3.11942012
110cilium movement (GO:0003341)3.10863017
111positive regulation of T-helper 1 type immune response (GO:0002827)3.10012592
112protein-lipid complex subunit organization (GO:0071825)3.09946788
113negative regulation of gluconeogenesis (GO:0045721)3.09939196
114negative regulation of metanephros development (GO:0072217)3.08543508
115L-ascorbic acid metabolic process (GO:0019852)3.08464280
116oxygen transport (GO:0015671)3.08299877
117drug catabolic process (GO:0042737)3.07869748
118desmosome organization (GO:0002934)3.07110000
119DNA methylation involved in gamete generation (GO:0043046)3.06685230
120epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06458233
121axonemal dynein complex assembly (GO:0070286)3.06001207
122thyroid hormone generation (GO:0006590)3.05854850
123short-chain fatty acid metabolic process (GO:0046459)3.05650141
124lipoprotein metabolic process (GO:0042157)3.05518998
125regulation of apoptotic process involved in morphogenesis (GO:1902337)3.04041994
126cellular ketone body metabolic process (GO:0046950)3.03518487
127exogenous drug catabolic process (GO:0042738)3.00687074
128oligosaccharide catabolic process (GO:0009313)3.00554587
129epithelial cilium movement (GO:0003351)2.99948279
130chemical homeostasis within a tissue (GO:0048875)2.99183443
131hydrogen peroxide metabolic process (GO:0042743)2.98431733
132cholesterol transport (GO:0030301)2.97717013
133sterol transport (GO:0015918)2.97717013
134cysteine metabolic process (GO:0006534)2.97042941
135cellular response to vitamin D (GO:0071305)2.96559779
136response to magnesium ion (GO:0032026)2.96539058
137regulation of Cdc42 GTPase activity (GO:0043088)2.95940629
138male meiosis I (GO:0007141)2.95789143
139plasma lipoprotein particle organization (GO:0071827)2.95663764
140myeloid dendritic cell activation (GO:0001773)2.93852125
141regulation of meiosis I (GO:0060631)2.91827611
142regulation of heterotypic cell-cell adhesion (GO:0034114)2.91466839
143positive regulation of T-helper cell differentiation (GO:0045624)2.91153433
144leukotriene biosynthetic process (GO:0019370)2.90902209
145positive regulation of glycogen biosynthetic process (GO:0045725)2.83692849
146hypothalamus development (GO:0021854)2.83399425
147fibroblast migration (GO:0010761)2.82498144
148low-density lipoprotein particle remodeling (GO:0034374)2.82296975
149negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.79033399
150protein targeting to Golgi (GO:0000042)2.77274902
151positive regulation of interleukin-1 beta secretion (GO:0050718)2.76887936
152cellular response to pH (GO:0071467)2.76538134
153regulation of T cell tolerance induction (GO:0002664)2.75650558
154glutathione derivative biosynthetic process (GO:1901687)2.73674291
155glutathione derivative metabolic process (GO:1901685)2.73674291
156acylglycerol homeostasis (GO:0055090)2.73432096
157triglyceride homeostasis (GO:0070328)2.73432096
158iron coordination entity transport (GO:1901678)2.72861200
159positive regulation of neutrophil chemotaxis (GO:0090023)2.72623672
160positive regulation of neutrophil migration (GO:1902624)2.72623672
161activation of Rac GTPase activity (GO:0032863)2.70920752
162surfactant homeostasis (GO:0043129)2.68919633
163intra-Golgi vesicle-mediated transport (GO:0006891)2.68844288
164regulation of endothelial cell differentiation (GO:0045601)2.68661605
165vitamin D metabolic process (GO:0042359)2.68184913
166positive regulation of glycolytic process (GO:0045821)2.67964872
167male meiosis (GO:0007140)2.67486361
168homocysteine metabolic process (GO:0050667)2.67240177
169establishment of protein localization to Golgi (GO:0072600)2.66382506
170L-phenylalanine catabolic process (GO:0006559)2.66353129
171erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.66353129
172histone H3-K9 demethylation (GO:0033169)2.66204840
173negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.65919487
174positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.64504224
175regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.64047465
176embryonic digestive tract development (GO:0048566)2.63670277
177L-phenylalanine metabolic process (GO:0006558)2.63652520
178erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.63652520
179ovulation (GO:0030728)2.63376035
180metanephric tubule development (GO:0072170)2.63081095
181metanephric nephron tubule development (GO:0072234)2.63081095
182regulation of type B pancreatic cell apoptotic process (GO:2000674)2.62845334
183cellular modified amino acid catabolic process (GO:0042219)2.62733847
184valine metabolic process (GO:0006573)2.62313539
185fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.62129073
186galactose metabolic process (GO:0006012)2.61220512
187protein localization to Golgi apparatus (GO:0034067)2.60787092
188terpenoid biosynthetic process (GO:0016114)2.60204749
189regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.59776185
190positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.59727259
191positive regulation of interleukin-1 secretion (GO:0050716)2.57649397
192cellular response to vitamin (GO:0071295)2.55585213
193cell adhesion mediated by integrin (GO:0033627)2.55477414
194renal tubule development (GO:0061326)2.54025341
195aspartate family amino acid catabolic process (GO:0009068)2.54000763
196cellular response to exogenous dsRNA (GO:0071360)2.53312672
197metanephric nephron epithelium development (GO:0072243)2.52808802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.36576955
2HIF1A_21447827_ChIP-Seq_MCF-7_Human3.34071891
3EGR1_23403033_ChIP-Seq_LIVER_Mouse3.10096435
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05022439
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.01885305
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.96416452
7ESR1_15608294_ChIP-ChIP_MCF-7_Human2.81912846
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.74235788
9VDR_22108803_ChIP-Seq_LS180_Human2.62811487
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.57727723
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.57300535
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.46846191
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.43677863
14ZNF274_21170338_ChIP-Seq_K562_Hela2.30464387
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.24075334
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.22675267
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19909459
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.07029288
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03536199
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.98563197
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.96016926
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.93381527
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89040291
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82289113
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77667878
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77527298
27DROSHA_22980978_ChIP-Seq_HELA_Human1.76088183
28TP53_16413492_ChIP-PET_HCT116_Human1.75576097
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74066036
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.71937168
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70552371
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.63671400
33ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63021226
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61614125
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.61233026
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60840130
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58323683
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56767665
39* SOX2_20726797_ChIP-Seq_SW620_Human1.53859952
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50738725
41AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.47906662
42CDX2_22108803_ChIP-Seq_LS180_Human1.45472647
43STAT3_23295773_ChIP-Seq_U87_Human1.44493550
44ER_23166858_ChIP-Seq_MCF-7_Human1.42574920
45HNF4A_19822575_ChIP-Seq_HepG2_Human1.42307831
46FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.41957200
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.40719251
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.40477932
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.38339773
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38230555
51FOXA1_25552417_ChIP-Seq_VCAP_Human1.33896667
52BCAT_22108803_ChIP-Seq_LS180_Human1.33340494
53ERA_21632823_ChIP-Seq_H3396_Human1.33316479
54AHR_22903824_ChIP-Seq_MCF-7_Human1.32527071
55VDR_24787735_ChIP-Seq_THP-1_Human1.32025237
56TDRD3_21172665_ChIP-Seq_MCF-7_Human1.30981164
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30665947
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29271631
59TCF4_23295773_ChIP-Seq_U87_Human1.28988203
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27894772
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27793855
62CLOCK_20551151_ChIP-Seq_293T_Human1.24898791
63STAT1_17558387_ChIP-Seq_HELA_Human1.23103776
64CDX2_20551321_ChIP-Seq_CACO-2_Human1.22040473
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18843482
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.18606263
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18048717
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17054006
69FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.16843419
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16284959
71GBX2_23144817_ChIP-Seq_PC3_Human1.16156379
72GATA4_25053715_ChIP-Seq_YYC3_Human1.15296947
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14015674
74SOX2_19829295_ChIP-Seq_ESCs_Human1.12612629
75NANOG_19829295_ChIP-Seq_ESCs_Human1.12612629
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11291994
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.09439437
78AR_20517297_ChIP-Seq_VCAP_Human1.09266919
79RACK7_27058665_Chip-Seq_MCF-7_Human1.09061452
80MYC_19829295_ChIP-Seq_ESCs_Human1.09014140
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.08548966
82TP53_18474530_ChIP-ChIP_U2OS_Human1.07326818
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.05379246
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05379246
85P53_21459846_ChIP-Seq_SAOS-2_Human1.05335471
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05064458
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03721839
88FOXH1_21741376_ChIP-Seq_EPCs_Human1.03332123
89AR_25329375_ChIP-Seq_VCAP_Human1.03281994
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03024104
91PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02978402
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.02877801
93MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02755191
94TAF15_26573619_Chip-Seq_HEK293_Human1.02567045
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02310025
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02296592
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01425945
98CJUN_26792858_Chip-Seq_BT549_Human1.00996327
99JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00959110
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.00696394
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00412390
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99620097
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.99248547
104RXR_22108803_ChIP-Seq_LS180_Human0.98783800
105SMAD4_21741376_ChIP-Seq_EPCs_Human0.97799679
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97780657
107BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96764679
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96326281
109TP53_22573176_ChIP-Seq_HFKS_Human0.95970326
110GATA3_24758297_ChIP-Seq_MCF-7_Human0.95624374
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95018280
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94133995
113SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93596573
114TCF4_22108803_ChIP-Seq_LS180_Human0.93034395
115* CBP_20019798_ChIP-Seq_JUKART_Human0.92984275
116* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92984275
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92956580
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.92825781
119TBX20_22080862_ChIP-Seq_HEART_Mouse0.92825781
120EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92576907
121RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92576907
122LXR_22292898_ChIP-Seq_THP-1_Human0.92527144
123SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91976265
124CEBPB_22108803_ChIP-Seq_LS180_Human0.91744438
125ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91316203
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91118082
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90658993
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90643274
129RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90519589
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90482953
131P300_19829295_ChIP-Seq_ESCs_Human0.89328103
132HOXB7_26014856_ChIP-Seq_BT474_Human0.89191447
133ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88782693
134WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88344232
135TP63_23658742_ChIP-Seq_EP156T_Human0.88333145
136PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88116610
137SMAD4_21799915_ChIP-Seq_A2780_Human0.87874849
138SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87206518
139P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87123918
140JARID2_20064375_ChIP-Seq_MESCs_Mouse0.86837873
141P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86728096
142OCT4_20526341_ChIP-Seq_ESCs_Human0.86664355
143FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86308713
144TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.85753229
145NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84208810
146NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84208810
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.83759083
148SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.83189869
149GATA6_25053715_ChIP-Seq_YYC3_Human0.81622301
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80762991
151NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80051729
152IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79725973
153FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.79190926
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77947985
155AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77812574
156GF1_26923725_Chip-Seq_HPCs_Mouse0.77754913
157NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77429306
158STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.76901445
159EGR1_19032775_ChIP-ChIP_M12_Human0.76858443
160FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76827735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.55970609
2MP0002876_abnormal_thyroid_physiology6.11280651
3MP0005645_abnormal_hypothalamus_physiol5.88551290
4MP0001984_abnormal_olfaction3.54461645
5MP0002877_abnormal_melanocyte_morpholog3.31476653
6MP0000685_abnormal_immune_system3.27653202
7MP0005360_urolithiasis3.08363028
8MP0002138_abnormal_hepatobiliary_system3.00975074
9MP0003123_paternal_imprinting2.99999474
10MP0004043_abnormal_pH_regulation2.90307269
11MP0001348_abnormal_lacrimal_gland2.86375237
12MP0003879_abnormal_hair_cell2.85551954
13MP0009840_abnormal_foam_cell2.77657866
14MP0000678_abnormal_parathyroid_gland2.77279107
15MP0003195_calcinosis2.67226602
16MP0001346_abnormal_lacrimal_gland2.64717688
17MP0005310_abnormal_salivary_gland2.62223965
18MP0000013_abnormal_adipose_tissue2.58488921
19MP0009643_abnormal_urine_homeostasis2.53665973
20MP0010329_abnormal_lipoprotein_level2.41346194
21MP0005332_abnormal_amino_acid2.39218192
22MP0001756_abnormal_urination2.35543452
23MP0001835_abnormal_antigen_presentation2.28874696
24MP0008877_abnormal_DNA_methylation2.17969170
25MP0004510_myositis2.13389748
26MP0005083_abnormal_biliary_tract2.09202187
27MP0006082_CNS_inflammation2.04894497
28MP0000003_abnormal_adipose_tissue1.94382116
29MP0004019_abnormal_vitamin_homeostasis1.90045507
30MP0001764_abnormal_homeostasis1.88199683
31MP0001666_abnormal_nutrient_absorption1.83488342
32MP0001873_stomach_inflammation1.82818790
33MP0002909_abnormal_adrenal_gland1.80291155
34MP0002136_abnormal_kidney_physiology1.77265472
35MP0002163_abnormal_gland_morphology1.74090027
36MP0003959_abnormal_lean_body1.72596462
37MP0000538_abnormal_urinary_bladder1.71353574
38MP0002277_abnormal_respiratory_mucosa1.68889101
39MP0005670_abnormal_white_adipose1.66774245
40MP0002132_abnormal_respiratory_system1.66750317
41MP0001765_abnormal_ion_homeostasis1.66583597
42MP0003878_abnormal_ear_physiology1.58897133
43MP0005377_hearing/vestibular/ear_phenot1.58897133
44MP0003252_abnormal_bile_duct1.53434054
45MP0000566_synostosis1.52295075
46MP0002928_abnormal_bile_duct1.48050026
47MP0005408_hypopigmentation1.43134518
48MP0003300_gastrointestinal_ulcer1.42616701
49MP0003283_abnormal_digestive_organ1.40905648
50MP0006054_spinal_hemorrhage1.38688150
51MP0008004_abnormal_stomach_pH1.37997297
52MP0005646_abnormal_pituitary_gland1.37119259
53MP0000639_abnormal_adrenal_gland1.35705509
54MP0002139_abnormal_hepatobiliary_system1.35061275
55MP0003638_abnormal_response/metabolism_1.33388830
56MP0005551_abnormal_eye_electrophysiolog1.31810875
57MP0005220_abnormal_exocrine_pancreas1.28942585
58MP0003122_maternal_imprinting1.25538006
59MP0004133_heterotaxia1.25152823
60MP0009333_abnormal_splenocyte_physiolog1.22165329
61MP0010234_abnormal_vibrissa_follicle1.21956916
62MP0001485_abnormal_pinna_reflex1.21609625
63MP0005636_abnormal_mineral_homeostasis1.21230795
64MP0005084_abnormal_gallbladder_morpholo1.18994369
65MP0002735_abnormal_chemical_nociception1.17904805
66MP0001944_abnormal_pancreas_morphology1.14238967
67MP0000372_irregular_coat_pigmentation1.13601118
68MP0001853_heart_inflammation1.13274818
69MP0003953_abnormal_hormone_level1.12549150
70MP0003806_abnormal_nucleotide_metabolis1.11651006
71MP0004264_abnormal_extraembryonic_tissu1.11059888
72MP0001879_abnormal_lymphatic_vessel1.11032168
73MP0009780_abnormal_chondrocyte_physiolo1.10180151
74MP0002118_abnormal_lipid_homeostasis1.09161286
75MP0000383_abnormal_hair_follicle1.09068626
76MP0001958_emphysema1.08858748
77MP0001502_abnormal_circadian_rhythm1.06978858
78MP0005389_reproductive_system_phenotype1.05302649
79MP0005379_endocrine/exocrine_gland_phen1.03865817
80MP0000516_abnormal_urinary_system1.03288523
81MP0005367_renal/urinary_system_phenotyp1.03288523
82MP0005671_abnormal_response_to1.01450586
83MP0002938_white_spotting0.96722197
84MP0009764_decreased_sensitivity_to0.94202992
85MP0002971_abnormal_brown_adipose0.88549631
86MP0008875_abnormal_xenobiotic_pharmacok0.88150428
87MP0001929_abnormal_gametogenesis0.86292717
88MP0005395_other_phenotype0.85780887
89MP0008874_decreased_physiological_sensi0.85561189
90MP0003787_abnormal_imprinting0.84749349
91MP0001919_abnormal_reproductive_system0.84242349
92MP0002210_abnormal_sex_determination0.83740286
93MP0005085_abnormal_gallbladder_physiolo0.83208184
94MP0002557_abnormal_social/conspecific_i0.82795138
95MP0003011_delayed_dark_adaptation0.82666535
96MP0010386_abnormal_urinary_bladder0.81831282
97MP0001664_abnormal_digestion0.81658126
98MP0005375_adipose_tissue_phenotype0.81501423
99MP0003698_abnormal_male_reproductive0.80811416
100MP0001270_distended_abdomen0.80533027
101MP0004885_abnormal_endolymph0.80381945
102MP0008872_abnormal_physiological_respon0.80219214
103MP0003941_abnormal_skin_development0.80040227
104MP0003936_abnormal_reproductive_system0.78876270
105MP0009046_muscle_twitch0.78846819
106MP0003656_abnormal_erythrocyte_physiolo0.77793786
107MP0005584_abnormal_enzyme/coenzyme_acti0.77514518
108MP0008995_early_reproductive_senescence0.77375329
109MP0003075_altered_response_to0.77089761
110MP0005647_abnormal_sex_gland0.76671135
111MP0001145_abnormal_male_reproductive0.74755610
112MP0003943_abnormal_hepatobiliary_system0.73757706
113MP0001324_abnormal_eye_pigmentation0.73178017
114MP0003938_abnormal_ear_development0.72725903
115MP0000653_abnormal_sex_gland0.72591869
116MP0005253_abnormal_eye_physiology0.72163620
117MP0002078_abnormal_glucose_homeostasis0.72094250
118MP0005319_abnormal_enzyme/_coenzyme0.72055147
119MP0002896_abnormal_bone_mineralization0.71576963
120MP0005410_abnormal_fertilization0.70702769
121MP0010352_gastrointestinal_tract_polyps0.70090633
122MP0003136_yellow_coat_color0.69565987
123MP0002160_abnormal_reproductive_system0.68525441
124MP0009115_abnormal_fat_cell0.67721000
125MP0005387_immune_system_phenotype0.67565356
126MP0001790_abnormal_immune_system0.67565356
127MP0003890_abnormal_embryonic-extraembry0.66590772
128MP0001542_abnormal_bone_strength0.66349400
129MP0005058_abnormal_lysosome_morphology0.64022573
130MP0001845_abnormal_inflammatory_respons0.63513046
131MP0001663_abnormal_digestive_system0.62987589
132MP0002168_other_aberrant_phenotype0.61499585
133MP0003186_abnormal_redox_activity0.60064780
134MP0010155_abnormal_intestine_physiology0.59981173
135MP0001851_eye_inflammation0.58812888
136MP0004147_increased_porphyrin_level0.57598176
137MP0000470_abnormal_stomach_morphology0.56238367
138MP0003045_fibrosis0.55691784
139MP0004484_altered_response_of0.55363517
140MP0005623_abnormal_meninges_morphology0.54946771
141MP0002135_abnormal_kidney_morphology0.52935105
142MP0005365_abnormal_bile_salt0.52423562
143MP0001501_abnormal_sleep_pattern0.50958240
144MP0001963_abnormal_hearing_physiology0.50441239
145MP0008469_abnormal_protein_level0.50345541
146MP0000681_abnormal_thyroid_gland0.49787486
147MP0001881_abnormal_mammary_gland0.49098441
148MP0003183_abnormal_peptide_metabolism0.48958493
149MP0002734_abnormal_mechanical_nocicepti0.48288294
150MP0003724_increased_susceptibility_to0.46886335
151MP0003453_abnormal_keratinocyte_physiol0.45587773
152MP0002970_abnormal_white_adipose0.45445354
153MP0003795_abnormal_bone_structure0.45221267
154MP0004782_abnormal_surfactant_physiolog0.44488162
155MP0005025_abnormal_response_to0.43202536
156MP0005451_abnormal_body_composition0.43000121
157MP0010678_abnormal_skin_adnexa0.42934969
158MP0009765_abnormal_xenobiotic_induced0.41213512
159MP0004272_abnormal_basement_membrane0.41131184
160MP0008789_abnormal_olfactory_epithelium0.41027757
161MP0002405_respiratory_system_inflammati0.40874090

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)6.31298500
2Increased circulating renin level (HP:0000848)6.24229586
3Hypokalemic alkalosis (HP:0001949)6.03249225
4Hyperactive renin-angiotensin system (HP:0000841)5.82808563
5Polyuria (HP:0000103)5.65075144
6Gout (HP:0001997)5.55862531
7Hypomagnesemia (HP:0002917)5.55157419
8Abnormality of chloride homeostasis (HP:0011422)5.32317311
9Abnormal urine output (HP:0012590)5.21800984
10Abnormality of renal excretion (HP:0011036)4.99506309
11Abnormal drinking behavior (HP:0030082)4.66843414
12Polydipsia (HP:0001959)4.66843414
13Abnormality of magnesium homeostasis (HP:0004921)4.64764744
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.49185471
15Hydroxyprolinuria (HP:0003080)4.41274554
16Abnormality of proline metabolism (HP:0010907)4.41274554
17Increased purine levels (HP:0004368)4.28388680
18Hyperuricemia (HP:0002149)4.28388680
19Renal salt wasting (HP:0000127)4.27847876
20Tetany (HP:0001281)4.25204434
21Hyperglycinuria (HP:0003108)4.17402772
22Hypothermia (HP:0002045)4.04665471
23Hyperaldosteronism (HP:0000859)4.04373878
24Abnormality of renin-angiotensin system (HP:0000847)4.01230466
25Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.77936250
26Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.74526152
27Alkalosis (HP:0001948)3.73118724
28Abnormality of purine metabolism (HP:0004352)3.52511488
29Type I diabetes mellitus (HP:0100651)3.52256492
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.31497690
31Hypoglycemic seizures (HP:0002173)3.27673013
32Abnormality of the nasal septum (HP:0000419)3.19977023
33Hypokalemia (HP:0002900)3.17421907
34Intrahepatic cholestasis (HP:0001406)3.11283396
35Congenital malformation of the right heart (HP:0011723)3.11120035
36Double outlet right ventricle (HP:0001719)3.11120035
37Hyperphosphatemia (HP:0002905)3.10576943
38Late onset (HP:0003584)3.07581131
39Proximal tubulopathy (HP:0000114)3.07557352
40Hyperinsulinemic hypoglycemia (HP:0000825)3.06841353
41Chronic mucocutaneous candidiasis (HP:0002728)3.01691410
42Recurrent cutaneous fungal infections (HP:0011370)3.01691410
43Ketoacidosis (HP:0001993)3.01618186
44Abnormality of glycine metabolism (HP:0010895)3.00893978
45Abnormality of serine family amino acid metabolism (HP:0010894)3.00893978
46Aplasia/Hypoplasia of the spleen (HP:0010451)2.98080010
47Fat malabsorption (HP:0002630)2.86632562
48Keratoconjunctivitis (HP:0001096)2.86272482
49Adrenal overactivity (HP:0002717)2.83118885
50Hypoglycemic coma (HP:0001325)2.82990903
51Rhinitis (HP:0012384)2.80933556
52Abnormal respiratory motile cilium physiology (HP:0012261)2.79582958
53Upper limb muscle weakness (HP:0003484)2.78532111
54Hypercalciuria (HP:0002150)2.77718371
55Abnormal auditory evoked potentials (HP:0006958)2.77502773
56Tongue fasciculations (HP:0001308)2.75671548
57Abnormality of calcium-phosphate metabolism (HP:0100530)2.73206085
58Absence seizures (HP:0002121)2.72012256
59Abnormal pupillary function (HP:0007686)2.71895216
60Spontaneous abortion (HP:0005268)2.67274596
61Muscle fibrillation (HP:0010546)2.66710749
62Abnormality of the pancreatic islet cells (HP:0006476)2.65105232
63Abnormality of endocrine pancreas physiology (HP:0012093)2.65105232
64Abnormal respiratory motile cilium morphology (HP:0005938)2.64840772
65Abnormal respiratory epithelium morphology (HP:0012253)2.64840772
66Confusion (HP:0001289)2.63106118
67Chronic bronchitis (HP:0004469)2.62846447
68Renal tubular acidosis (HP:0001947)2.57943557
69Steatorrhea (HP:0002570)2.56525517
70Abnormal ciliary motility (HP:0012262)2.54334423
71Interstitial pulmonary disease (HP:0006530)2.51700763
72Abnormality of sodium homeostasis (HP:0010931)2.51639677
73Abnormality of midbrain morphology (HP:0002418)2.49600661
74Molar tooth sign on MRI (HP:0002419)2.49600661
75Chronic hepatic failure (HP:0100626)2.48079324
76Abnormality of nucleobase metabolism (HP:0010932)2.44995381
77Absent/shortened dynein arms (HP:0200106)2.41932013
78Dynein arm defect of respiratory motile cilia (HP:0012255)2.41932013
79Abnormality of potassium homeostasis (HP:0011042)2.40530786
80Hypobetalipoproteinemia (HP:0003563)2.39319095
81Bicornuate uterus (HP:0000813)2.34892161
82Dehydration (HP:0001944)2.32752860
83Hypoplasia of the capital femoral epiphysis (HP:0003090)2.28845009
84Barrel-shaped chest (HP:0001552)2.25999867
85Ketosis (HP:0001946)2.24741386
86Hepatoblastoma (HP:0002884)2.24298495
87Tubular atrophy (HP:0000092)2.21247103
88Lip pit (HP:0100267)2.19490145
89Abnormal pancreas size (HP:0012094)2.18864046
90Generalized aminoaciduria (HP:0002909)2.17376194
91Stage 5 chronic kidney disease (HP:0003774)2.12758804
92Tachypnea (HP:0002789)2.11166741
93Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.09734587
94Prolonged partial thromboplastin time (HP:0003645)2.09541703
95Hypoplasia of the uterus (HP:0000013)2.09448034
96Truncus arteriosus (HP:0001660)2.08642952
97Metaphyseal irregularity (HP:0003025)2.08562177
98Abnormality of macular pigmentation (HP:0008002)2.07883815
99Dialeptic seizures (HP:0011146)2.07656061
100Generalized muscle weakness (HP:0003324)2.07646115
101Eczematoid dermatitis (HP:0000976)2.07179542
102Pancreatic cysts (HP:0001737)2.05172495
103Abnormality of the pubic bones (HP:0003172)2.05002716
104Vacuolated lymphocytes (HP:0001922)2.04831367
105Abnormality of aromatic amino acid family metabolism (HP:0004338)2.02550746
106Prolonged neonatal jaundice (HP:0006579)2.02236367
107Abnormality of the gastric mucosa (HP:0004295)2.01270924
108Nephrocalcinosis (HP:0000121)2.00674294
109Symptomatic seizures (HP:0011145)2.00089320
110Disproportionate short-trunk short stature (HP:0003521)1.97954802
111Glomerulosclerosis (HP:0000096)1.97849204
112Abnormality of macrophages (HP:0004311)1.97182628
113Enlarged kidneys (HP:0000105)1.96488419
114Myositis (HP:0100614)1.96343677
115Type 2 muscle fiber atrophy (HP:0003554)1.95636537
116Bronchiectasis (HP:0002110)1.94506980
117Hyperammonemia (HP:0001987)1.92770849
118Abnormality of fatty-acid metabolism (HP:0004359)1.92511455
119Annular pancreas (HP:0001734)1.91617917
120Nephrolithiasis (HP:0000787)1.90756309
121Hypoplasia of dental enamel (HP:0006297)1.90513646
122Glycosuria (HP:0003076)1.89245700
123Abnormality of urine glucose concentration (HP:0011016)1.89245700
124Recurrent skin infections (HP:0001581)1.88644049
125Vascular calcification (HP:0004934)1.88049657
126Abnormality of the renal cortex (HP:0011035)1.87976034
127Chondrocalcinosis (HP:0000934)1.85420236
128Abnormal urine phosphate concentration (HP:0012599)1.84146650
129Xerostomia (HP:0000217)1.82388262
130Mitral stenosis (HP:0001718)1.82064740
131Hypolipoproteinemia (HP:0010981)1.81336464
132Recurrent fungal infections (HP:0002841)1.77489194
133Asplenia (HP:0001746)1.77116903
134Type I transferrin isoform profile (HP:0003642)1.76764051
135Tubulointerstitial nephritis (HP:0001970)1.76394752
136Amyloidosis (HP:0011034)1.75679863
137Hypoplastic ischia (HP:0003175)1.75091395
138Abnormality of alanine metabolism (HP:0010916)1.74296553
139Hyperalaninemia (HP:0003348)1.74296553
140Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74296553
141Abnormality of the labia minora (HP:0012880)1.73765301
142Large for gestational age (HP:0001520)1.73119768
143Abnormality of the common coagulation pathway (HP:0010990)1.72053969
144Abnormality of Sharpey fibers (HP:0100685)1.71221730
145Fatigable weakness (HP:0003473)1.70745084
146Abnormality of the neuromuscular junction (HP:0003398)1.70745084
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.70420284
148Absent epiphyses (HP:0010577)1.70420284
149Bilateral microphthalmos (HP:0007633)1.70232023
150Short nail (HP:0001799)1.69971628
151Cystic liver disease (HP:0006706)1.69055864
152Cardiovascular calcification (HP:0011915)1.67582528
153Malnutrition (HP:0004395)1.66298448
154Abnormality of the ischium (HP:0003174)1.66220688
155Abnormality of the renal medulla (HP:0100957)1.65947561
156Hyperphosphaturia (HP:0003109)1.64589577
157Hypotension (HP:0002615)1.63557499
158Colitis (HP:0002583)1.63203113
159Bell-shaped thorax (HP:0001591)1.61953733
160Hypercortisolism (HP:0001578)1.61863893
161Right ventricular cardiomyopathy (HP:0011663)1.61720611
162Bilateral sensorineural hearing impairment (HP:0008619)1.61656659
163Abnormality of the wing of the ilium (HP:0011867)1.61609876
164Hyperglycemia (HP:0003074)1.61535192
165Onycholysis (HP:0001806)1.61343780
166Abnormality of the fingertips (HP:0001211)1.60084615
167Muscle fiber atrophy (HP:0100295)1.59929640

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.19051415
2WNK35.03697424
3WNK44.84917444
4TRIM284.78132751
5OXSR14.29183380
6DYRK1B3.89597781
7MAP3K143.61636166
8INSRR3.52880144
9FGFR23.21988833
10TIE12.77108732
11PHKG22.68032647
12PHKG12.68032647
13IRAK42.55139511
14RIPK12.50062083
15IRAK32.38378427
16BRSK12.35397645
17PTK62.29563418
18EPHA22.22551246
19NUAK12.14312775
20ERBB32.07277652
21STK391.96613991
22AKT31.91924931
23PINK11.77031261
24NTRK31.76862491
25TBK11.72407825
26MST41.60714810
27PIM21.60713176
28KDR1.55197367
29CASK1.53259011
30FER1.53039425
31MUSK1.33918140
32EPHA41.32532564
33EPHB11.27244548
34FGFR41.26440490
35BMPR21.20360028
36PTK21.15457018
37ACVR1B1.15292843
38ADRBK21.14843254
39PAK31.12423324
40EIF2AK31.12251625
41BMPR1B1.10716744
42FLT31.09242573
43MAPK111.08176114
44PRKCI1.04251090
45PASK1.02596131
46CAMKK21.01516757
47BCKDK1.01317580
48MAPK151.00138033
49SGK4940.98422901
50SGK2230.98422901
51DYRK30.95669987
52PKN20.95199286
53PDK20.94580212
54STK30.94443522
55IKBKE0.91580803
56NLK0.91400772
57PIK3CA0.91342602
58IRAK10.91155513
59PRKAA20.89445457
60CDK120.88263605
61TGFBR10.88153780
62CHUK0.87921991
63NME10.86732378
64ERN10.86294197
65STK38L0.85608299
66MAP3K90.84440288
67BRSK20.83939221
68ITK0.82999231
69PNCK0.82389719
70EPHA30.77222889
71PLK20.72155184
72TEC0.69817313
73MAP2K20.69393194
74LRRK20.69050908
75BCR0.67165016
76JAK30.66240218
77CAMK1G0.66110956
78TRIB30.65800820
79TAOK30.64994275
80KSR10.64773859
81NEK10.64477847
82MAP3K10.64332952
83LATS10.63949273
84STK240.63550096
85MAP2K60.63223097
86PRKCQ0.62853079
87MST1R0.61928587
88MAP3K70.61333703
89PRKCE0.61262556
90PBK0.61139662
91STK380.60756686
92CAMK1D0.59549295
93MAP3K30.59516823
94PIK3CG0.59490174
95TSSK60.59137886
96EPHB20.59048965
97TGFBR20.57531580
98GRK60.56877601
99FGFR10.56473993
100PAK40.55118333
101MAPKAPK30.55052604
102PRKCG0.53145897
103GSK3A0.52134216
104PRKCD0.49941360
105PDGFRB0.49569612
106PDK30.48827936
107PDK40.48827936
108NTRK10.48817866
109MAP2K10.47308890
110TESK10.46594374
111FGFR30.45574239
112LMTK20.45545445
113CSNK1E0.43177445
114TYK20.41839143
115SGK20.41766882
116ADRBK10.40990745
117CAMK2B0.39413323
118RET0.39394684
119PRKACB0.38914767
120GRK10.37998483
121JAK20.37926597
122ROCK10.37801000
123CDC42BPA0.37632480
124CAMK2G0.37529765
125CDK70.36828395
126WNK10.36398802
127BTK0.36186948
128EGFR0.35198122
129GRK50.34413077
130CSNK2A20.32229104
131ERBB20.31921452
132CSF1R0.31832801
133SGK30.31681501
134PKN10.31483366
135IKBKB0.31438719
136ERBB40.30341558
137CAMK2D0.29037920
138PRKCA0.28299924
139PDK10.27901857
140PRKCZ0.27827093
141PRKG10.27322372
142STK110.27171047
143CSNK1A10.27033561
144ATM0.26955168
145IGF1R0.26749365
146MAP3K20.26699492
147TLK10.26539508
148ARAF0.26291776
149MELK0.26248394
150MET0.26247873
151CSNK1A1L0.25534727
152PTK2B0.25338190
153PRKAA10.24606588
154SGK10.24523137
155PIM10.23866654

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.95453655
2Olfactory transduction_Homo sapiens_hsa047403.42439202
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.40203113
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.87611211
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.73958690
6Vitamin digestion and absorption_Homo sapiens_hsa049772.58239226
7Histidine metabolism_Homo sapiens_hsa003402.52638689
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43323674
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.43310158
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.25342826
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21549347
12Propanoate metabolism_Homo sapiens_hsa006402.19008112
13Pyruvate metabolism_Homo sapiens_hsa006202.15442663
14Fat digestion and absorption_Homo sapiens_hsa049752.14242774
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01125621
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90921810
17Collecting duct acid secretion_Homo sapiens_hsa049661.87562218
18Vitamin B6 metabolism_Homo sapiens_hsa007501.85027897
19Retinol metabolism_Homo sapiens_hsa008301.82682946
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.79627864
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77905869
22Phenylalanine metabolism_Homo sapiens_hsa003601.73534976
23Butanoate metabolism_Homo sapiens_hsa006501.67234377
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.65470362
25Nitrogen metabolism_Homo sapiens_hsa009101.58330531
26Tryptophan metabolism_Homo sapiens_hsa003801.57560355
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.57119409
28Complement and coagulation cascades_Homo sapiens_hsa046101.56853419
29Peroxisome_Homo sapiens_hsa041461.56519595
30Bile secretion_Homo sapiens_hsa049761.55828660
31Arginine biosynthesis_Homo sapiens_hsa002201.54269951
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47120097
33Caffeine metabolism_Homo sapiens_hsa002321.42952095
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41068712
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40886352
36beta-Alanine metabolism_Homo sapiens_hsa004101.40450413
37Sulfur metabolism_Homo sapiens_hsa009201.38279903
38Asthma_Homo sapiens_hsa053101.38147311
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37427788
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25993173
41Thyroid hormone synthesis_Homo sapiens_hsa049181.23160395
42Steroid biosynthesis_Homo sapiens_hsa001001.23106654
43Fatty acid degradation_Homo sapiens_hsa000711.22684882
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.20059392
45Arginine and proline metabolism_Homo sapiens_hsa003301.13878479
46Other glycan degradation_Homo sapiens_hsa005111.12902536
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12640256
48Mineral absorption_Homo sapiens_hsa049781.12404036
49Vibrio cholerae infection_Homo sapiens_hsa051101.10707384
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09318990
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.08107690
52Primary immunodeficiency_Homo sapiens_hsa053401.02390919
53Galactose metabolism_Homo sapiens_hsa000521.00622432
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99339519
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98954532
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93515798
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.92663351
58Gastric acid secretion_Homo sapiens_hsa049710.90250366
59Taste transduction_Homo sapiens_hsa047420.88247224
60Arachidonic acid metabolism_Homo sapiens_hsa005900.87275836
61Fatty acid elongation_Homo sapiens_hsa000620.85663443
62Starch and sucrose metabolism_Homo sapiens_hsa005000.85626779
63Regulation of autophagy_Homo sapiens_hsa041400.85423697
64Carbon metabolism_Homo sapiens_hsa012000.83062002
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82719475
66Type II diabetes mellitus_Homo sapiens_hsa049300.82224418
67Tight junction_Homo sapiens_hsa045300.81923830
68Antigen processing and presentation_Homo sapiens_hsa046120.81406522
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.76560985
70Phototransduction_Homo sapiens_hsa047440.75965580
71Protein digestion and absorption_Homo sapiens_hsa049740.75917931
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.75174727
73Insulin secretion_Homo sapiens_hsa049110.74927579
74Fatty acid biosynthesis_Homo sapiens_hsa000610.74754989
75African trypanosomiasis_Homo sapiens_hsa051430.74714878
76Glycerolipid metabolism_Homo sapiens_hsa005610.73682444
77Glutathione metabolism_Homo sapiens_hsa004800.73678400
78Fructose and mannose metabolism_Homo sapiens_hsa000510.73449637
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72523760
80Melanoma_Homo sapiens_hsa052180.70966301
81Lysine degradation_Homo sapiens_hsa003100.69683928
82Lysosome_Homo sapiens_hsa041420.68586861
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.67903753
84Type I diabetes mellitus_Homo sapiens_hsa049400.67723279
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63032872
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62583219
87N-Glycan biosynthesis_Homo sapiens_hsa005100.61575607
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60718133
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60387413
90PPAR signaling pathway_Homo sapiens_hsa033200.59523447
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59313524
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58725463
93Rheumatoid arthritis_Homo sapiens_hsa053230.57868390
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.57113916
95Autoimmune thyroid disease_Homo sapiens_hsa053200.57020861
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56895192
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56438340
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56429779
99Metabolic pathways_Homo sapiens_hsa011000.55713632
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55147357
101Leishmaniasis_Homo sapiens_hsa051400.54728580
102Tyrosine metabolism_Homo sapiens_hsa003500.54709469
103Protein export_Homo sapiens_hsa030600.54299026
104Fatty acid metabolism_Homo sapiens_hsa012120.53658605
105Basal transcription factors_Homo sapiens_hsa030220.53603003
106Homologous recombination_Homo sapiens_hsa034400.53528778
107Nicotine addiction_Homo sapiens_hsa050330.53149770
108Oxidative phosphorylation_Homo sapiens_hsa001900.51223096
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50978769
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49678590
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49346314
112Sphingolipid metabolism_Homo sapiens_hsa006000.47704890
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.43132128
114Rap1 signaling pathway_Homo sapiens_hsa040150.42931890
115ABC transporters_Homo sapiens_hsa020100.41679196
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39407018
117Small cell lung cancer_Homo sapiens_hsa052220.38931030
118Biosynthesis of amino acids_Homo sapiens_hsa012300.37200247
119Tuberculosis_Homo sapiens_hsa051520.37092162
120Salivary secretion_Homo sapiens_hsa049700.36798244
121Toxoplasmosis_Homo sapiens_hsa051450.35952330
122Ovarian steroidogenesis_Homo sapiens_hsa049130.35587278
123Phagosome_Homo sapiens_hsa041450.34564314
124Circadian rhythm_Homo sapiens_hsa047100.33718284
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33176910
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33012113
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31406511
128Dorso-ventral axis formation_Homo sapiens_hsa043200.31204273
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.31149482
130Cocaine addiction_Homo sapiens_hsa050300.31005079
131Apoptosis_Homo sapiens_hsa042100.29672007
132Amoebiasis_Homo sapiens_hsa051460.28708912
133Legionellosis_Homo sapiens_hsa051340.28562018
134Ras signaling pathway_Homo sapiens_hsa040140.28407810
135Synaptic vesicle cycle_Homo sapiens_hsa047210.26436929
136Chemical carcinogenesis_Homo sapiens_hsa052040.23852674
137Ether lipid metabolism_Homo sapiens_hsa005650.22783017
138Hepatitis C_Homo sapiens_hsa051600.22593197
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22095683
140TNF signaling pathway_Homo sapiens_hsa046680.21419583
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21273926
142Parkinsons disease_Homo sapiens_hsa050120.21004770
143Selenocompound metabolism_Homo sapiens_hsa004500.20645898
144Linoleic acid metabolism_Homo sapiens_hsa005910.20517700
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20464715
146Pentose phosphate pathway_Homo sapiens_hsa000300.18913659
147Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18576364

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