RNF186

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)7.79682832
2regulation of guanylate cyclase activity (GO:0031282)5.81501805
3intestinal absorption (GO:0050892)5.65490147
4L-phenylalanine metabolic process (GO:0006558)5.65070358
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.65070358
6L-phenylalanine catabolic process (GO:0006559)5.56536927
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.56536927
8maintenance of gastrointestinal epithelium (GO:0030277)5.56393341
9intestinal cholesterol absorption (GO:0030299)5.03599800
10aromatic amino acid family catabolic process (GO:0009074)4.86380130
11homocysteine metabolic process (GO:0050667)4.85953119
12sulfur amino acid catabolic process (GO:0000098)4.85120308
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.79268978
14drug catabolic process (GO:0042737)4.77459387
15bile acid and bile salt transport (GO:0015721)4.75645473
16glomerular filtration (GO:0003094)4.74730042
17flavonoid metabolic process (GO:0009812)4.67164958
18cysteine metabolic process (GO:0006534)4.63543559
19oligosaccharide biosynthetic process (GO:0009312)4.61047541
20digestion (GO:0007586)4.57121267
21angiotensin maturation (GO:0002003)4.54778753
22regulation of bile acid biosynthetic process (GO:0070857)4.54020642
23urea cycle (GO:0000050)4.53426754
24urea metabolic process (GO:0019627)4.53426754
25drug transmembrane transport (GO:0006855)4.50085106
26regulation of cellular extravasation (GO:0002691)4.37280369
27positive regulation of guanylate cyclase activity (GO:0031284)4.33023898
28calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.30194001
29tryptophan catabolic process (GO:0006569)4.29799490
30indole-containing compound catabolic process (GO:0042436)4.29799490
31indolalkylamine catabolic process (GO:0046218)4.29799490
32renal filtration (GO:0097205)4.25805435
33ethanol metabolic process (GO:0006067)4.21868271
34nitrogen cycle metabolic process (GO:0071941)4.15658883
35sulfate transmembrane transport (GO:1902358)4.13934552
36regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.12787554
37regulation of cholesterol homeostasis (GO:2000188)4.12707339
38bile acid metabolic process (GO:0008206)4.12264061
39antibacterial humoral response (GO:0019731)4.11886434
40regulation of triglyceride catabolic process (GO:0010896)4.09225354
41tryptophan metabolic process (GO:0006568)4.07554502
42cobalamin metabolic process (GO:0009235)4.07424891
43glyoxylate metabolic process (GO:0046487)4.05707991
44triglyceride homeostasis (GO:0070328)4.04253121
45acylglycerol homeostasis (GO:0055090)4.04253121
46proline metabolic process (GO:0006560)4.04036340
47epithelial structure maintenance (GO:0010669)4.03998957
48cellular ketone body metabolic process (GO:0046950)4.03398909
49NADH metabolic process (GO:0006734)4.02561136
50positive regulation of pseudopodium assembly (GO:0031274)4.00229457
51cellular response to zinc ion (GO:0071294)3.98525704
52regulation of cholesterol esterification (GO:0010872)3.98116307
53kynurenine metabolic process (GO:0070189)3.97220878
54exogenous drug catabolic process (GO:0042738)3.96648323
55alpha-linolenic acid metabolic process (GO:0036109)3.95232383
56antimicrobial humoral response (GO:0019730)3.94493149
57proline biosynthetic process (GO:0006561)3.93580152
58drug transport (GO:0015893)3.93258888
59primary alcohol catabolic process (GO:0034310)3.91665088
60bundle of His cell to Purkinje myocyte communication (GO:0086069)3.90554881
61cellular glucuronidation (GO:0052695)3.89985554
62regulation of autophagic vacuole assembly (GO:2000785)3.88088377
63high-density lipoprotein particle remodeling (GO:0034375)3.85924407
64negative regulation of sterol transport (GO:0032372)3.82093958
65negative regulation of cholesterol transport (GO:0032375)3.82093958
66transcytosis (GO:0045056)3.81849194
67fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.81522385
68protein-lipid complex remodeling (GO:0034368)3.80362636
69macromolecular complex remodeling (GO:0034367)3.80362636
70plasma lipoprotein particle remodeling (GO:0034369)3.80362636
71short-chain fatty acid metabolic process (GO:0046459)3.79817285
72UDP-N-acetylglucosamine metabolic process (GO:0006047)3.77676739
73bile acid biosynthetic process (GO:0006699)3.77154406
74lysine metabolic process (GO:0006553)3.76913570
75lysine catabolic process (GO:0006554)3.76913570
76regulation of systemic arterial blood pressure by hormone (GO:0001990)3.76090224
77regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.76090224
78endocrine process (GO:0050886)3.76090224
79desmosome organization (GO:0002934)3.74818232
80phospholipid efflux (GO:0033700)3.73566910
81regulation of cGMP biosynthetic process (GO:0030826)3.72511672
82aromatic amino acid family metabolic process (GO:0009072)3.66892488
83nucleoside diphosphate biosynthetic process (GO:0009133)3.66557942
84serine family amino acid catabolic process (GO:0009071)3.65533947
85uronic acid metabolic process (GO:0006063)3.61471743
86glucuronate metabolic process (GO:0019585)3.61471743
87regulation of vacuole organization (GO:0044088)3.59079435
88lipoprotein metabolic process (GO:0042157)3.58324698
89glucocorticoid biosynthetic process (GO:0006704)3.56686453
90regulation of pseudopodium assembly (GO:0031272)3.56564971
91GDP-mannose metabolic process (GO:0019673)3.56262475
92drug metabolic process (GO:0017144)3.55996202
93intestinal epithelial cell development (GO:0060576)3.54548143
94amino-acid betaine metabolic process (GO:0006577)3.54287078
95renal system process involved in regulation of blood volume (GO:0001977)3.54184870
96plasma lipoprotein particle assembly (GO:0034377)3.51578509
97cholesterol homeostasis (GO:0042632)3.50338364
98receptor guanylyl cyclase signaling pathway (GO:0007168)3.49239415
99positive regulation of glycolytic process (GO:0045821)3.47907461
100positive regulation of lipoprotein lipase activity (GO:0051006)3.47505865
101positive regulation of triglyceride lipase activity (GO:0061365)3.47505865
102sterol homeostasis (GO:0055092)3.47457878
103reverse cholesterol transport (GO:0043691)3.47133708
104auditory receptor cell differentiation (GO:0042491)3.46864510
105regulation of respiratory burst (GO:0060263)3.45392191
106sulfation (GO:0051923)3.45190470
107ketone body metabolic process (GO:1902224)3.44889824
108purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.43600007
1093-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.43600007
110ethanol oxidation (GO:0006069)3.43328966
111cellular response to cadmium ion (GO:0071276)3.42877434
112phosphatidylinositol acyl-chain remodeling (GO:0036149)3.41750854
113low-density lipoprotein particle remodeling (GO:0034374)3.40646548
114glutamine family amino acid biosynthetic process (GO:0009084)3.39740691
115cellular modified amino acid catabolic process (GO:0042219)3.39159926
116cholesterol efflux (GO:0033344)3.38723032
117very-low-density lipoprotein particle assembly (GO:0034379)3.37698856
118regulation of systemic arterial blood pressure (GO:0003073)3.36847997
119fatty acid beta-oxidation (GO:0006635)3.36768307
120urate metabolic process (GO:0046415)3.36043021
121regulation of vitamin metabolic process (GO:0030656)3.33681947
122regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.32716177
123complement activation, alternative pathway (GO:0006957)3.29652879
124glycolipid catabolic process (GO:0019377)3.28994652
125response to nitrosative stress (GO:0051409)3.28562304
126endocrine pancreas development (GO:0031018)3.26972434
127arginine metabolic process (GO:0006525)3.26748668
128alpha-amino acid catabolic process (GO:1901606)3.23846282
129fructose metabolic process (GO:0006000)3.23479766
130fatty acid oxidation (GO:0019395)3.22818855
131sulfate transport (GO:0008272)3.22574570
132polyketide metabolic process (GO:0030638)3.21432977
133doxorubicin metabolic process (GO:0044598)3.21432977
134daunorubicin metabolic process (GO:0044597)3.21432977
135glutamate metabolic process (GO:0006536)3.20771764
136phospholipid homeostasis (GO:0055091)3.20537261
137cellular amino acid catabolic process (GO:0009063)3.20428662
138glutathione derivative metabolic process (GO:1901685)3.20163653
139glutathione derivative biosynthetic process (GO:1901687)3.20163653
140nucleotide-sugar biosynthetic process (GO:0009226)3.18213848
141peptidyl-glutamic acid carboxylation (GO:0017187)3.17225300
142protein carboxylation (GO:0018214)3.17225300
143digestive system process (GO:0022600)3.16745199
144protein-lipid complex assembly (GO:0065005)3.16503246
145complement activation, classical pathway (GO:0006958)3.16402172
146lipid oxidation (GO:0034440)3.15363852
147benzene-containing compound metabolic process (GO:0042537)3.14065885
148phosphatidylserine acyl-chain remodeling (GO:0036150)3.11763656
149fatty acid catabolic process (GO:0009062)3.11695889
150eosinophil chemotaxis (GO:0048245)3.09289281
151O-glycan processing (GO:0016266)3.08504500
152diacylglycerol metabolic process (GO:0046339)3.07585252
153epoxygenase P450 pathway (GO:0019373)3.04069085
154regulation of cGMP metabolic process (GO:0030823)3.03426980
155fucosylation (GO:0036065)2.99988431
156adhesion of symbiont to host cell (GO:0044650)2.95605907
157virion attachment to host cell (GO:0019062)2.95605907
158positive regulation of fatty acid beta-oxidation (GO:0032000)2.95384130
159fat-soluble vitamin biosynthetic process (GO:0042362)2.93956609
160cGMP-mediated signaling (GO:0019934)2.93265096
161aminoglycoside antibiotic metabolic process (GO:0030647)2.91725094
162peptide hormone processing (GO:0016486)2.91062588
163glutathione biosynthetic process (GO:0006750)2.89381050
164membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.83202310
165positive regulation of glycoprotein biosynthetic process (GO:0010560)2.81296941
166membrane lipid catabolic process (GO:0046466)2.79672274
167arginine catabolic process (GO:0006527)2.77327485
168positive regulation of glycoprotein metabolic process (GO:1903020)2.76935138
169bicarbonate transport (GO:0015701)2.76574523
170phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.76367443
171positive regulation of fatty acid oxidation (GO:0046321)2.76066458
172primary alcohol metabolic process (GO:0034308)2.75166277
173glycoside metabolic process (GO:0016137)2.74407956
174eosinophil migration (GO:0072677)2.73517943
175positive regulation of cGMP biosynthetic process (GO:0030828)2.70164611
176nonribosomal peptide biosynthetic process (GO:0019184)2.69548130
177membrane repolarization during action potential (GO:0086011)2.68168365
178receptor recycling (GO:0001881)2.66903823

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.73483309
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.45403290
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.05598189
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.19105419
5TP63_17297297_ChIP-ChIP_HaCaT_Human5.00373199
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.90117169
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.42116845
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.87634095
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.79173135
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.58100201
11CDX2_20551321_ChIP-Seq_CACO-2_Human3.49208921
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.48645586
13SOX2_27498859_Chip-Seq_STOMACH_Mouse3.16991306
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.02608842
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.70422756
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.67246288
17GATA4_25053715_ChIP-Seq_YYC3_Human2.65899414
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.27672463
19SOX2_20726797_ChIP-Seq_SW620_Human2.17221798
20* GATA6_25053715_ChIP-Seq_YYC3_Human2.15953953
21ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.10521006
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.60966168
23HNF4A_19822575_ChIP-Seq_HepG2_Human1.57856207
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57717929
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57693888
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.55805944
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.55798854
28GATA1_22025678_ChIP-Seq_K562_Human1.52951520
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.48829298
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.44146322
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41324699
32* TCF4_18268006_ChIP-ChIP_LS174T_Human1.40434921
33CLOCK_20551151_ChIP-Seq_293T_Human1.39163612
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38600270
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.36428528
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35479991
37NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26966406
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24650354
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23851447
40DROSHA_22980978_ChIP-Seq_HELA_Human1.22943529
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16796550
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14884138
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.14403108
44RACK7_27058665_Chip-Seq_MCF-7_Human1.14384156
45BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12249187
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.10456425
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08762862
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08259049
49ZNF263_19887448_ChIP-Seq_K562_Human1.07818183
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06793137
51FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.05386196
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04933446
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03855442
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03603637
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02983951
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02884063
57FOXA1_25552417_ChIP-Seq_VCAP_Human1.02440365
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01979484
59ESR1_20079471_ChIP-ChIP_T-47D_Human0.99955669
60* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98941040
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98930585
62RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98722432
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97398881
64AR_21909140_ChIP-Seq_LNCAP_Human0.95917299
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94765233
66GATA3_24758297_ChIP-Seq_MCF-7_Human0.93992837
67RUNX1_27514584_Chip-Seq_MCF-7_Human0.93353073
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92508548
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92484947
70* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92130027
71ATF3_27146783_Chip-Seq_COLON_Human0.92026785
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90590137
73* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90460773
74* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.90378063
75SA1_27219007_Chip-Seq_Bcells_Human0.89591968
76BCL6_27268052_Chip-Seq_Bcells_Human0.88508460
77RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88248484
78BCOR_27268052_Chip-Seq_Bcells_Human0.87844420
79P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86854073
80LXR_22292898_ChIP-Seq_THP-1_Human0.86829387
81SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86232380
82* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85253624
83FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83943552
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83464675
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82792919
86FOXH1_21741376_ChIP-Seq_ESCs_Human0.82610695
87NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81179225
88AR_20517297_ChIP-Seq_VCAP_Human0.80937919
89PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79272244
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.78765908
91RXRA_24833708_ChIP-Seq_LIVER_Mouse0.77979066
92ETV2_25802403_ChIP-Seq_MESCs_Mouse0.77717291
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.77679658
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77234517
95CREB1_26743006_Chip-Seq_LNCaP_Human0.76821167
96* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.75574144
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.75249774
98RXR_22108803_ChIP-Seq_LS180_Human0.74929509
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.72508019
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72201904
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.72021025
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71853318
103TP63_22573176_ChIP-Seq_HFKS_Human0.71522593
104* HNFA_21074721_ChIP-Seq_CACO-2_Human0.71363785
105E2F1_20622854_ChIP-Seq_HELA_Human0.71245722
106RARA_24833708_ChIP-Seq_LIVER_Mouse0.71104866
107STAT3_1855785_ChIP-Seq_MESCs_Mouse0.70869306
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70658940
109GATA2_19941826_ChIP-Seq_K562_Human0.69682088
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68919770
111NANOG_20526341_ChIP-Seq_ESCs_Human0.68825570
112KAP1_22055183_ChIP-Seq_ESCs_Mouse0.68724299
113BCAT_22108803_ChIP-Seq_LS180_Human0.67903290
114FOXM1_26456572_ChIP-Seq_MCF-7_Human0.67799364
115EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.67323791
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.66564471
117KLF5_25053715_ChIP-Seq_YYC3_Human0.66091688
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.64519296
119* CEBPB_22108803_ChIP-Seq_LS180_Human0.62847095
120CTCF_20526341_ChIP-Seq_ESCs_Human0.60865798
121* CTCF_27219007_Chip-Seq_Bcells_Human0.59787689
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.59557957
123STAT1_20625510_ChIP-Seq_HELA_Human0.59526502
124TAF2_19829295_ChIP-Seq_ESCs_Human0.59319548
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.59144658
126CDX2_22108803_ChIP-Seq_LS180_Human0.59098568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.13070693
2MP0002139_abnormal_hepatobiliary_system6.67075996
3MP0005085_abnormal_gallbladder_physiolo5.22554597
4MP0005365_abnormal_bile_salt4.69115499
5MP0008875_abnormal_xenobiotic_pharmacok4.17243869
6MP0001666_abnormal_nutrient_absorption3.84287102
7MP0003252_abnormal_bile_duct3.56993545
8MP0003806_abnormal_nucleotide_metabolis2.98334580
9MP0004019_abnormal_vitamin_homeostasis2.73668282
10MP0009840_abnormal_foam_cell2.73555726
11MP0010329_abnormal_lipoprotein_level2.68472014
12MP0002138_abnormal_hepatobiliary_system2.60718499
13MP0010234_abnormal_vibrissa_follicle2.48345865
14MP0005083_abnormal_biliary_tract2.46365594
15MP0005332_abnormal_amino_acid2.37426491
16MP0004264_abnormal_extraembryonic_tissu2.26948311
17MP0003195_calcinosis2.21015726
18MP0000462_abnormal_digestive_system2.17167888
19MP0003868_abnormal_feces_composition2.08686851
20MP0004043_abnormal_pH_regulation2.05639363
21MP0008004_abnormal_stomach_pH2.04838651
22MP0009643_abnormal_urine_homeostasis1.98336080
23MP0001873_stomach_inflammation1.89380009
24MP0003300_gastrointestinal_ulcer1.84790205
25MP0003866_abnormal_defecation1.83683899
26MP0010155_abnormal_intestine_physiology1.76326230
27MP0004147_increased_porphyrin_level1.69717394
28MP0001663_abnormal_digestive_system1.66490048
29MP0003191_abnormal_cellular_cholesterol1.62777606
30MP0002118_abnormal_lipid_homeostasis1.61649143
31MP0002166_altered_tumor_susceptibility1.60994811
32MP0005381_digestive/alimentary_phenotyp1.56846210
33MP0000609_abnormal_liver_physiology1.55973455
34MP0003879_abnormal_hair_cell1.50601091
35MP0005636_abnormal_mineral_homeostasis1.50145909
36MP0005319_abnormal_enzyme/_coenzyme1.45333114
37MP0004782_abnormal_surfactant_physiolog1.43442486
38MP0001765_abnormal_ion_homeostasis1.42468062
39MP0009379_abnormal_foot_pigmentation1.41578141
40MP0000490_abnormal_crypts_of1.39521336
41MP0004858_abnormal_nervous_system1.35390630
42MP0001764_abnormal_homeostasis1.33760061
43MP0002009_preneoplasia1.28492388
44MP0000013_abnormal_adipose_tissue1.28091577
45MP0001664_abnormal_digestion1.27499212
46MP0001756_abnormal_urination1.21297347
47MP0003045_fibrosis1.21162725
48MP0003705_abnormal_hypodermis_morpholog1.19569512
49MP0000477_abnormal_intestine_morphology1.19450113
50MP0005584_abnormal_enzyme/coenzyme_acti1.14315144
51MP0005084_abnormal_gallbladder_morpholo1.11354573
52MP0005451_abnormal_body_composition1.09976690
53MP0010678_abnormal_skin_adnexa1.02449667
54MP0002006_tumorigenesis1.01177567
55MP0005220_abnormal_exocrine_pancreas1.01000595
56MP0000538_abnormal_urinary_bladder1.00979602
57MP0001501_abnormal_sleep_pattern1.00342937
58MP0009780_abnormal_chondrocyte_physiolo0.99894804
59MP0002136_abnormal_kidney_physiology0.97148010
60MP0000537_abnormal_urethra_morphology0.96937438
61MP0000465_gastrointestinal_hemorrhage0.94281840
62MP0006082_CNS_inflammation0.91147035
63MP0003186_abnormal_redox_activity0.89740037
64MP0005409_darkened_coat_color0.86827021
65MP0002796_impaired_skin_barrier0.86723411
66MP0008872_abnormal_physiological_respon0.83974665
67MP0005408_hypopigmentation0.83911754
68MP0002098_abnormal_vibrissa_morphology0.83499585
69MP0002277_abnormal_respiratory_mucosa0.82905275
70MP0002971_abnormal_brown_adipose0.82514331
71MP0009642_abnormal_blood_homeostasis0.82149996
72MP0000516_abnormal_urinary_system0.82056633
73MP0005367_renal/urinary_system_phenotyp0.82056633
74MP0002254_reproductive_system_inflammat0.81685115
75MP0003172_abnormal_lysosome_physiology0.81388220
76MP0006036_abnormal_mitochondrial_physio0.80198858
77MP0009697_abnormal_copulation0.80121013
78MP0005670_abnormal_white_adipose0.79706955
79MP0002822_catalepsy0.79473852
80MP0009764_decreased_sensitivity_to0.79167922
81MP0005167_abnormal_blood-brain_barrier0.77867034
82MP0002876_abnormal_thyroid_physiology0.77372523
83MP0002078_abnormal_glucose_homeostasis0.76120476
84MP0005058_abnormal_lysosome_morphology0.75759858
85MP0009785_altered_susceptibility_to0.74814770
86MP0005448_abnormal_energy_balance0.72678443
87MP0003283_abnormal_digestive_organ0.72245569
88MP0008469_abnormal_protein_level0.71224684
89MP0000598_abnormal_liver_morphology0.70768918
90MP0001944_abnormal_pancreas_morphology0.69624381
91MP0010352_gastrointestinal_tract_polyps0.69170880
92MP0003787_abnormal_imprinting0.68984925
93MP0003075_altered_response_to0.67546747
94MP0002837_dystrophic_cardiac_calcinosis0.67470715
95MP0000681_abnormal_thyroid_gland0.66020082
96MP0002693_abnormal_pancreas_physiology0.65307219
97MP0000678_abnormal_parathyroid_gland0.64206346
98MP0001188_hyperpigmentation0.63222631
99MP0000566_synostosis0.62726723
100MP0003724_increased_susceptibility_to0.61072868
101MP0005310_abnormal_salivary_gland0.59875591
102MP0000470_abnormal_stomach_morphology0.59367389
103MP0005166_decreased_susceptibility_to0.59268647
104MP0010386_abnormal_urinary_bladder0.59251603
105MP0005535_abnormal_body_temperature0.59207692
106MP0008775_abnormal_heart_ventricle0.58133232
107MP0005666_abnormal_adipose_tissue0.57774206
108MP0000230_abnormal_systemic_arterial0.57559480
109MP0002638_abnormal_pupillary_reflex0.57098605
110MP0003183_abnormal_peptide_metabolism0.56771246
111MP0003953_abnormal_hormone_level0.56765480
112MP0005174_abnormal_tail_pigmentation0.56674156
113MP0009763_increased_sensitivity_to0.56607534
114MP0003453_abnormal_keratinocyte_physiol0.56196251
115MP0005025_abnormal_response_to0.56054868
116MP0002928_abnormal_bile_duct0.55947675
117MP0009765_abnormal_xenobiotic_induced0.54628525
118MP0001485_abnormal_pinna_reflex0.53928352
119MP0006054_spinal_hemorrhage0.52455921
120MP0004947_skin_inflammation0.52369230
121MP0001845_abnormal_inflammatory_respons0.51609551
122MP0005376_homeostasis/metabolism_phenot0.50218566
123MP0002132_abnormal_respiratory_system0.49670497
124MP0002909_abnormal_adrenal_gland0.49624454
125MP0003878_abnormal_ear_physiology0.47333722
126MP0005377_hearing/vestibular/ear_phenot0.47333722
127MP0002060_abnormal_skin_morphology0.46929377
128MP0009053_abnormal_anal_canal0.46897061
129MP0000613_abnormal_salivary_gland0.45579415
130MP0003718_maternal_effect0.44209034
131MP0005334_abnormal_fat_pad0.43971685

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)5.73182173
2Intrahepatic cholestasis (HP:0001406)5.15657301
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.04718830
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.74417338
5Ileus (HP:0002595)4.57100833
6Abnormality of glutamine family amino acid metabolism (HP:0010902)4.56262710
7Hypobetalipoproteinemia (HP:0003563)4.54060570
8Hypoglycemic coma (HP:0001325)4.19216678
9Xanthomatosis (HP:0000991)4.13633229
10Conjugated hyperbilirubinemia (HP:0002908)4.07105582
11Malnutrition (HP:0004395)3.84061059
12Hyperammonemia (HP:0001987)3.82319967
13Deep venous thrombosis (HP:0002625)3.81692027
14Ketoacidosis (HP:0001993)3.80355020
15Hyperactive renin-angiotensin system (HP:0000841)3.78634158
16Gout (HP:0001997)3.68064899
17Hyperglycinuria (HP:0003108)3.67590119
18Fat malabsorption (HP:0002630)3.62624416
19Ketosis (HP:0001946)3.62235345
20Glycosuria (HP:0003076)3.56292278
21Abnormality of urine glucose concentration (HP:0011016)3.56292278
22Insulin-resistant diabetes mellitus (HP:0000831)3.41129782
23Prolonged partial thromboplastin time (HP:0003645)3.39155534
24Hyperaldosteronism (HP:0000859)3.38421356
25Abnormality of purine metabolism (HP:0004352)3.36641293
26Systemic lupus erythematosus (HP:0002725)3.35454251
27Ventricular fibrillation (HP:0001663)3.32786328
28Hyperglycemia (HP:0003074)3.30480613
29Abnormality of serine family amino acid metabolism (HP:0010894)3.25209447
30Abnormality of glycine metabolism (HP:0010895)3.25209447
31Symptomatic seizures (HP:0011145)3.24953643
32Late onset (HP:0003584)3.22742647
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.17716359
34Abnormality of chloride homeostasis (HP:0011422)3.15383958
35Hyperglycinemia (HP:0002154)3.08486484
36Alkalosis (HP:0001948)3.07950307
37Abnormality of sulfur amino acid metabolism (HP:0004339)3.07463230
38Flat acetabular roof (HP:0003180)3.07070169
39Proximal tubulopathy (HP:0000114)3.05326414
40Hypokalemia (HP:0002900)3.02311619
41Dicarboxylic aciduria (HP:0003215)3.02126950
42Abnormality of dicarboxylic acid metabolism (HP:0010995)3.02126950
43Hypoglycemic seizures (HP:0002173)3.00862893
44Abnormality of fatty-acid metabolism (HP:0004359)3.00622983
45Generalized aminoaciduria (HP:0002909)2.96690332
46Hypolipoproteinemia (HP:0010981)2.96388911
47Abnormality of nucleobase metabolism (HP:0010932)2.95295010
48Abdominal distention (HP:0003270)2.93407667
49Metabolic alkalosis (HP:0200114)2.88536050
50Congenital sensorineural hearing impairment (HP:0008527)2.86650365
51Hyperphosphaturia (HP:0003109)2.85591195
52Abnormality of magnesium homeostasis (HP:0004921)2.84069756
53Abnormality of endocrine pancreas physiology (HP:0012093)2.82984567
54Abnormality of the pancreatic islet cells (HP:0006476)2.82984567
55Lethargy (HP:0001254)2.74447773
56Metabolic acidosis (HP:0001942)2.72795384
57Epidermoid cyst (HP:0200040)2.71402828
58Hemorrhage of the eye (HP:0011885)2.70640120
59Chronic diarrhea (HP:0002028)2.69909339
60Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.67126781
61Exocrine pancreatic insufficiency (HP:0001738)2.64442696
62Hyponatremia (HP:0002902)2.62307284
63Abnormality of potassium homeostasis (HP:0011042)2.61127415
64Increased purine levels (HP:0004368)2.61010289
65Hyperuricemia (HP:0002149)2.61010289
66Hyperinsulinemic hypoglycemia (HP:0000825)2.56996271
67Visceral angiomatosis (HP:0100761)2.56363021
68Hematochezia (HP:0002573)2.56345795
69Hyperbilirubinemia (HP:0002904)2.56300600
70Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.56154380
71Abnormality of proline metabolism (HP:0010907)2.53145434
72Hydroxyprolinuria (HP:0003080)2.53145434
73Right ventricular cardiomyopathy (HP:0011663)2.51666495
74Hypercholesterolemia (HP:0003124)2.51522006
75Large for gestational age (HP:0001520)2.49813985
76Retinal atrophy (HP:0001105)2.48924170
77Complement deficiency (HP:0004431)2.48517229
78Hyperlipoproteinemia (HP:0010980)2.45944525
79Delayed CNS myelination (HP:0002188)2.45715749
80Hepatic necrosis (HP:0002605)2.44371444
81Hyperparathyroidism (HP:0000843)2.44178961
82Insulin resistance (HP:0000855)2.43559022
83Abnormality of the intrinsic pathway (HP:0010989)2.42547774
84Increased muscle lipid content (HP:0009058)2.40748833
85Widely patent fontanelles and sutures (HP:0004492)2.40330956
86Abnormality of vitamin metabolism (HP:0100508)2.39803025
87Abnormality of renin-angiotensin system (HP:0000847)2.39584937
88Bone cyst (HP:0012062)2.38944661
89Abnormal urine phosphate concentration (HP:0012599)2.37272968
90Abnormality of the common coagulation pathway (HP:0010990)2.36334950
91Esophageal varix (HP:0002040)2.36289594
92Cerebral edema (HP:0002181)2.35159659
93Acanthocytosis (HP:0001927)2.34869637
94Vascular calcification (HP:0004934)2.32255730
95Abnormal hemoglobin (HP:0011902)2.30817038
96Vomiting (HP:0002013)2.28389829
97Syncope (HP:0001279)2.26885008
98Focal segmental glomerulosclerosis (HP:0000097)2.25099649
99Abnormality of methionine metabolism (HP:0010901)2.24401534
100Facial shape deformation (HP:0011334)2.22873670
101Potter facies (HP:0002009)2.22873670
102Hemangiomatosis (HP:0007461)2.20220723
103Hypomagnesemia (HP:0002917)2.20135284
104Pili torti (HP:0003777)2.19373776
105Steatorrhea (HP:0002570)2.18770800
106Acute encephalopathy (HP:0006846)2.18098645
107Growth hormone excess (HP:0000845)2.16721780
108Abnormality of vitamin B metabolism (HP:0004340)2.16223359
109Abnormal biliary tract morphology (HP:0012440)2.15923516
110Pancreatic islet-cell hyperplasia (HP:0004510)2.14824242
111Joint hemorrhage (HP:0005261)2.14819305
112Increased intramyocellular lipid droplets (HP:0012240)2.14633693
113Abnormality of pyrimidine metabolism (HP:0004353)2.12602444
114Abnormality of the vitamin B12 metabolism (HP:0004341)2.11865636
115Pancreatitis (HP:0001733)2.11712836
116Abnormal tarsal ossification (HP:0008369)2.10184652
117Glomerulonephritis (HP:0000099)2.08708964
118Irritability (HP:0000737)2.08078195
119Rickets (HP:0002748)2.07945778
120Lipid accumulation in hepatocytes (HP:0006561)2.07262303
121Nephrolithiasis (HP:0000787)2.04618193
122Myoglobinuria (HP:0002913)2.04264100
123Hypokalemic alkalosis (HP:0001949)2.01516865
124Hypoalphalipoproteinemia (HP:0003233)2.01390898
125Protuberant abdomen (HP:0001538)2.01146232
126Hepatocellular carcinoma (HP:0001402)2.00737130
127Cardiovascular calcification (HP:0011915)2.00592997
128Abnormal enzyme/coenzyme activity (HP:0012379)2.00225089
129Hypophosphatemia (HP:0002148)1.98750707
130Adrenal overactivity (HP:0002717)1.98623110
131Abnormality of serum amino acid levels (HP:0003112)1.97580920
132Villous atrophy (HP:0011473)1.96586166
133Abnormality of small intestinal villus morphology (HP:0011472)1.96586166
134Petechiae (HP:0000967)1.96512785
135Abnormal pancreas size (HP:0012094)1.95533615
136Increased circulating renin level (HP:0000848)1.95140739
137Micronodular cirrhosis (HP:0001413)1.94887273
138Abnormal hair laboratory examination (HP:0003328)1.94614397
139Abnormality of sodium homeostasis (HP:0010931)1.93261901
140Dehydration (HP:0001944)1.91926699
141Hyperphosphatemia (HP:0002905)1.89387808
142Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79595167
143Tetraparesis (HP:0002273)1.79128384
144Confusion (HP:0001289)1.78205432
145Hyperkalemia (HP:0002153)1.77032424
146Abnormality of complement system (HP:0005339)1.73595061
147Multiple lipomas (HP:0001012)1.72208975
148Glomerulosclerosis (HP:0000096)1.71796437
149Flat capital femoral epiphysis (HP:0003370)1.70918880
150Neonatal short-limb short stature (HP:0008921)1.70813593
151Ventricular arrhythmia (HP:0004308)1.69736405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.93749849
2LMTK24.31984489
3FRK4.29150981
4MST1R3.92827767
5BCKDK3.24902469
6FGFR22.96517287
7MAP2K22.94046182
8ERN12.83640940
9MST42.80011698
10WNK42.75114689
11TNIK2.73289253
12NME12.69384529
13MAP3K22.62682583
14IRAK32.48153881
15TAOK32.34566634
16INSRR2.23503668
17MAPK152.21018107
18NUAK12.12960290
19PTK62.10588789
20MAP2K62.10185303
21PRKG22.06265633
22STK38L2.00804001
23PINK11.98703601
24FGFR31.96904494
25MAP3K31.91483516
26STK391.76228165
27FGFR41.75945939
28PBK1.72705835
29OXSR11.72346427
30EPHA21.53081494
31EPHB21.43953510
32PKN21.31605520
33WNK31.29244303
34PTK21.23575047
35SIK11.23175780
36MET1.21952752
37PIK3CG1.21197484
38ERBB21.18651518
39PIK3CA1.18621088
40BLK1.14206171
41MYLK1.12264885
42DDR21.10844321
43STK31.09490841
44GRK61.09376441
45RIPK11.08836062
46MAP3K110.99863001
47PHKG10.95351765
48PHKG20.95351765
49MAPK110.94598847
50LATS10.91918122
51MAP2K10.91614957
52CDK120.90719110
53PRKAA20.89647335
54TTK0.85729278
55MAP3K100.84875270
56ERBB40.84663132
57MAP3K70.82472753
58YES10.81049499
59PRKCI0.79721313
60SCYL20.79345325
61HIPK20.77364475
62EPHA30.77330016
63CDC42BPA0.77064331
64IRAK40.77013267
65TLK10.76766247
66FLT30.76035315
67IRAK20.75247670
68DAPK20.73278213
69PDK20.70325514
70TRIB30.68249901
71MAP3K120.66709329
72TIE10.66183805
73MAP3K10.65180467
74GRK10.63667725
75TESK10.62071248
76FER0.60769856
77TBK10.60012961
78TEC0.59998159
79CAMK2G0.58030679
80GSK3A0.57050934
81PDK10.56926040
82CSK0.53610982
83IRAK10.50949537
84LRRK20.50936959
85PDPK10.50570423
86ADRBK20.48566171
87OBSCN0.48464341
88KSR20.48432265
89DYRK1B0.47946708
90JAK20.46398810
91RPS6KB20.45894522
92NEK90.44892475
93PRKACG0.44405833
94ROCK10.43949156
95STK40.43872261
96CAMK2D0.43032345
97EIF2AK30.42609470
98EPHB10.42128890
99PRKAA10.41905258
100PASK0.40974171
101PRKCA0.40026600
102CAMK2B0.38923063
103STK240.37841830
104TYK20.35353634
105PAK40.35280524
106PRKCQ0.33582773
107PRKCZ0.33033328
108BMPR1B0.32716442
109KIT0.30064147
110AURKB0.28053339
111CSNK1A10.27207096
112MAP3K80.27104033
113CHUK0.26918569
114PRKCE0.26906798
115SRC0.26768564
116PDK30.26042727
117PDK40.26042727
118ADRBK10.25872313
119EIF2AK10.24977853
120PIM20.24854355
121RIPK40.24736899
122MAP4K10.22318495
123ABL20.22074767
124NME20.21840816
125IKBKE0.20846146
126STK110.19900475
127TAOK10.19873129
128ZAP700.19871506
129STK380.19126173
130MATK0.19089511
131BRAF0.18829592
132NLK0.18187140
133TESK20.17906623
134LYN0.17848284
135RPS6KB10.17652541
136SGK10.17335409
137PRKCD0.17331605
138DAPK30.14811909

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.84656845
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.02650006
3Sulfur metabolism_Homo sapiens_hsa009202.99536789
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.82140764
5Tryptophan metabolism_Homo sapiens_hsa003802.82077224
6Nitrogen metabolism_Homo sapiens_hsa009102.77462735
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.72843000
8Fatty acid degradation_Homo sapiens_hsa000712.59859175
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43305196
10Fat digestion and absorption_Homo sapiens_hsa049752.43008387
11Histidine metabolism_Homo sapiens_hsa003402.33456849
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.22124940
13Butanoate metabolism_Homo sapiens_hsa006502.14990190
14Arginine biosynthesis_Homo sapiens_hsa002202.12762426
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07997554
16Bile secretion_Homo sapiens_hsa049761.79092954
17Peroxisome_Homo sapiens_hsa041461.74434102
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73539204
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73409023
20Propanoate metabolism_Homo sapiens_hsa006401.73333421
21Pyruvate metabolism_Homo sapiens_hsa006201.70065248
22Folate biosynthesis_Homo sapiens_hsa007901.67836445
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67107375
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.67054586
25beta-Alanine metabolism_Homo sapiens_hsa004101.64250956
26Selenocompound metabolism_Homo sapiens_hsa004501.63423333
27Chemical carcinogenesis_Homo sapiens_hsa052041.62200959
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62198281
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.60837498
30PPAR signaling pathway_Homo sapiens_hsa033201.59084161
31Starch and sucrose metabolism_Homo sapiens_hsa005001.52034210
32Vitamin digestion and absorption_Homo sapiens_hsa049771.51911842
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.46697816
34Fatty acid metabolism_Homo sapiens_hsa012121.45714907
35Glutathione metabolism_Homo sapiens_hsa004801.44253970
36Arginine and proline metabolism_Homo sapiens_hsa003301.44211115
37Retinol metabolism_Homo sapiens_hsa008301.42565137
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42417793
39Caffeine metabolism_Homo sapiens_hsa002321.40670120
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36300013
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.35545242
42Mineral absorption_Homo sapiens_hsa049781.33104844
43Complement and coagulation cascades_Homo sapiens_hsa046101.29644525
44Carbon metabolism_Homo sapiens_hsa012001.23351025
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18931185
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17589089
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14547201
48Fatty acid elongation_Homo sapiens_hsa000621.07176669
49ABC transporters_Homo sapiens_hsa020101.05377221
50Fructose and mannose metabolism_Homo sapiens_hsa000511.04233502
51Glycerolipid metabolism_Homo sapiens_hsa005611.03552727
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00102830
53Phenylalanine metabolism_Homo sapiens_hsa003600.99360430
54Galactose metabolism_Homo sapiens_hsa000520.97602131
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96517626
56Type I diabetes mellitus_Homo sapiens_hsa049400.96394964
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94265319
58Tyrosine metabolism_Homo sapiens_hsa003500.90248762
59Pentose phosphate pathway_Homo sapiens_hsa000300.88636004
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87443356
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85752279
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85186913
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85151727
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.82879405
65Biosynthesis of amino acids_Homo sapiens_hsa012300.82250326
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81976246
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79404876
68Oxidative phosphorylation_Homo sapiens_hsa001900.79402445
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77386665
70Lysine degradation_Homo sapiens_hsa003100.76296689
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75179707
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.74909265
73Renin-angiotensin system_Homo sapiens_hsa046140.73332959
74Linoleic acid metabolism_Homo sapiens_hsa005910.72235127
75Asthma_Homo sapiens_hsa053100.69959493
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68834161
77Steroid biosynthesis_Homo sapiens_hsa001000.67914498
78Staphylococcus aureus infection_Homo sapiens_hsa051500.65549495
79Protein digestion and absorption_Homo sapiens_hsa049740.63215802
80Parkinsons disease_Homo sapiens_hsa050120.62036789
81Metabolic pathways_Homo sapiens_hsa011000.61467015
82Arachidonic acid metabolism_Homo sapiens_hsa005900.58029593
83Sulfur relay system_Homo sapiens_hsa041220.55032445
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54212937
85Ovarian steroidogenesis_Homo sapiens_hsa049130.51648367
86Thyroid hormone synthesis_Homo sapiens_hsa049180.47804442
87Alzheimers disease_Homo sapiens_hsa050100.47518728
88Type II diabetes mellitus_Homo sapiens_hsa049300.46848155
89Allograft rejection_Homo sapiens_hsa053300.37919437
90Renin secretion_Homo sapiens_hsa049240.37589612
91Autoimmune thyroid disease_Homo sapiens_hsa053200.36497727
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33458817
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.30224532
94Pancreatic secretion_Homo sapiens_hsa049720.29096641
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29057817
96Huntingtons disease_Homo sapiens_hsa050160.27625005
97Protein export_Homo sapiens_hsa030600.26938195
98Graft-versus-host disease_Homo sapiens_hsa053320.26659763
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.24265536
100Pertussis_Homo sapiens_hsa051330.19456843
101Insulin resistance_Homo sapiens_hsa049310.18207335
102Other glycan degradation_Homo sapiens_hsa005110.17484407
103Hepatitis C_Homo sapiens_hsa051600.17111942
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14564448
105Vibrio cholerae infection_Homo sapiens_hsa051100.14161387
106One carbon pool by folate_Homo sapiens_hsa006700.13403124
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12490357
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11593592
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.11034182
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.10297093
111Insulin secretion_Homo sapiens_hsa049110.09901015
112N-Glycan biosynthesis_Homo sapiens_hsa005100.08374934
113Tight junction_Homo sapiens_hsa045300.07396466
114Ether lipid metabolism_Homo sapiens_hsa005650.07178861
115Collecting duct acid secretion_Homo sapiens_hsa049660.06361482
116Sphingolipid metabolism_Homo sapiens_hsa006000.06126685
117Bladder cancer_Homo sapiens_hsa052190.04899758
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.04582351
119Salivary secretion_Homo sapiens_hsa049700.04491808
120Influenza A_Homo sapiens_hsa051640.01517414
121Lysosome_Homo sapiens_hsa041420.00863962

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