RNF19A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.76512453
2sperm motility (GO:0030317)9.17827353
3cilium or flagellum-dependent cell motility (GO:0001539)8.90212272
4acrosome assembly (GO:0001675)8.26499898
5sperm-egg recognition (GO:0035036)7.91406906
6cell wall macromolecule metabolic process (GO:0044036)7.78438539
7cell wall macromolecule catabolic process (GO:0016998)7.78438539
8acrosome reaction (GO:0007340)7.73025717
9multicellular organism reproduction (GO:0032504)7.61723395
10plasma membrane fusion (GO:0045026)7.44126977
11binding of sperm to zona pellucida (GO:0007339)7.27111437
12cell-cell recognition (GO:0009988)7.22197657
13reproduction (GO:0000003)6.61154290
14axonemal dynein complex assembly (GO:0070286)6.60182441
15piRNA metabolic process (GO:0034587)6.50341676
16spermatid development (GO:0007286)6.37997644
17motile cilium assembly (GO:0044458)6.37691027
18epithelial cilium movement (GO:0003351)6.29886082
19male meiosis (GO:0007140)5.79957419
20synaptonemal complex organization (GO:0070193)5.54648751
21negative regulation of inclusion body assembly (GO:0090084)5.40994140
22synaptonemal complex assembly (GO:0007130)5.35718976
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.31896210
24cilium movement (GO:0003341)5.09990760
25single fertilization (GO:0007338)4.93485725
26regulation of cilium movement (GO:0003352)4.63221312
27spermatogenesis (GO:0007283)4.50783490
28male gamete generation (GO:0048232)4.48744558
29fertilization (GO:0009566)4.23823765
30gamete generation (GO:0007276)4.12858668
31sperm capacitation (GO:0048240)4.10484612
32monoubiquitinated protein deubiquitination (GO:0035520)4.04249086
33regulation of B cell receptor signaling pathway (GO:0050855)4.04017097
34regulation of inclusion body assembly (GO:0090083)3.91706698
35organic cation transport (GO:0015695)3.91198762
36cellular response to interleukin-15 (GO:0071350)3.90114027
37seminiferous tubule development (GO:0072520)3.86007807
38cellular process involved in reproduction in multicellular organism (GO:0022412)3.85218674
39response to interleukin-15 (GO:0070672)3.78684215
40DNA methylation involved in gamete generation (GO:0043046)3.76945037
41genitalia morphogenesis (GO:0035112)3.76750993
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.74911041
43germ cell development (GO:0007281)3.71222532
44nuclear pore complex assembly (GO:0051292)3.70997765
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.59438550
46male meiosis I (GO:0007141)3.55764527
47ventricular system development (GO:0021591)3.51876036
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.50226637
49antigen processing and presentation of endogenous antigen (GO:0019883)3.48519615
50regulation of protein polyubiquitination (GO:1902914)3.46639335
51negative regulation of cell killing (GO:0031342)3.45264759
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.45264759
53CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.45063292
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.44994455
55microtubule depolymerization (GO:0007019)3.37499406
56chromosome organization involved in meiosis (GO:0070192)3.37386404
57cell recognition (GO:0008037)3.30888416
58regulation of isotype switching to IgG isotypes (GO:0048302)3.29870671
59multicellular organismal reproductive process (GO:0048609)3.27746143
60cytidine deamination (GO:0009972)3.23570308
61cytidine metabolic process (GO:0046087)3.23570308
62cytidine catabolic process (GO:0006216)3.23570308
63activated T cell proliferation (GO:0050798)3.19965173
64regulation of interleukin-12 biosynthetic process (GO:0045075)3.19837383
65regulation of B cell differentiation (GO:0045577)3.18376547
66positive regulation of natural killer cell mediated immunity (GO:0002717)3.16218231
67regulation of regulatory T cell differentiation (GO:0045589)3.15183018
68meiotic nuclear division (GO:0007126)3.14754489
69interferon-gamma secretion (GO:0072643)3.13455139
70T cell migration (GO:0072678)3.12647269
71regulation of alpha-beta T cell proliferation (GO:0046640)3.11216622
72sexual reproduction (GO:0019953)3.09162423
73positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.08798964
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.07928351
75T cell selection (GO:0045058)3.07785528
76calcium ion-dependent exocytosis (GO:0017156)3.04889391
77pyrimidine ribonucleoside catabolic process (GO:0046133)3.01651591
78cellular response to type I interferon (GO:0071357)3.01413214
79type I interferon signaling pathway (GO:0060337)3.01413214
80response to type I interferon (GO:0034340)3.00606028
81growth hormone receptor signaling pathway (GO:0060396)2.99988859
82B cell receptor signaling pathway (GO:0050853)2.99260319
83regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.98442068
84regulation of natural killer cell mediated immunity (GO:0002715)2.98442068
85positive regulation of gamma-delta T cell activation (GO:0046645)2.98237519
86positive regulation of B cell differentiation (GO:0045579)2.95802117
87gene silencing by RNA (GO:0031047)2.95652889
88chromosome condensation (GO:0030261)2.93719817
89interferon-gamma-mediated signaling pathway (GO:0060333)2.92775095
90negative regulation of T cell mediated immunity (GO:0002710)2.92335476
91macroautophagy (GO:0016236)2.90672263
92NIK/NF-kappaB signaling (GO:0038061)2.88510252
93pore complex assembly (GO:0046931)2.86401893
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.86077125
95response to muramyl dipeptide (GO:0032495)2.85431541
96protein K11-linked deubiquitination (GO:0035871)2.80136496
97regulation of gamma-delta T cell differentiation (GO:0045586)2.77807614
98positive thymic T cell selection (GO:0045059)2.77665856
99DNA packaging (GO:0006323)2.77259393
100regulation of B cell proliferation (GO:0030888)2.77047505
101carnitine transport (GO:0015879)2.75012127
102amino-acid betaine transport (GO:0015838)2.75012127
103mitotic sister chromatid cohesion (GO:0007064)2.74721619
104regulation of chronic inflammatory response (GO:0002676)2.74441196
105lactate metabolic process (GO:0006089)2.74281702
106positive regulation of alpha-beta T cell proliferation (GO:0046641)2.74170071
107negative regulation of B cell activation (GO:0050869)2.73725068
108regulation of T-helper 1 cell differentiation (GO:0045625)2.73533821
109T-helper cell differentiation (GO:0042093)2.72691916
110CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.72691916
111positive regulation of interleukin-2 production (GO:0032743)2.71553847
112carnitine transmembrane transport (GO:1902603)2.70697452
113positive regulation of humoral immune response (GO:0002922)2.70467981
114positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.70277134
115lymphocyte costimulation (GO:0031294)2.70085432
116regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.69952232
117cellular response to ethanol (GO:0071361)2.69776514
118T cell costimulation (GO:0031295)2.69636891
119antigen receptor-mediated signaling pathway (GO:0050851)2.68919565
120B cell homeostasis (GO:0001782)2.68665920
121multicellular organismal development (GO:0007275)2.68490398
122positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.68004640
123regulation of gamma-delta T cell activation (GO:0046643)2.67769372
124negative regulation of B cell proliferation (GO:0030889)2.66974655
125positive regulation of cell killing (GO:0031343)2.66678320
126germinal center formation (GO:0002467)2.66127030
127meiosis I (GO:0007127)2.65980785
128interferon-gamma production (GO:0032609)2.65759256
129positive regulation of granulocyte differentiation (GO:0030854)2.65641776
130nuclear pore organization (GO:0006999)2.65436360
131T cell receptor signaling pathway (GO:0050852)2.64539765
132regulation of interleukin-2 biosynthetic process (GO:0045076)2.63818113
133negative T cell selection (GO:0043383)2.62613111
134cellular response to growth hormone stimulus (GO:0071378)2.62478935
135regulation of leukocyte mediated cytotoxicity (GO:0001910)2.62251898
136meiotic cell cycle (GO:0051321)2.61674814
137negative thymic T cell selection (GO:0045060)2.61093694
138regulation of cell killing (GO:0031341)2.60089562
139tolerance induction (GO:0002507)2.59945667
140positive regulation of B cell proliferation (GO:0030890)2.59292396
141myeloid dendritic cell differentiation (GO:0043011)2.58950913
142regulation of microtubule-based movement (GO:0060632)2.57984401
143regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.57926968
144membrane protein intracellular domain proteolysis (GO:0031293)2.57745950
145regulation of chromatin binding (GO:0035561)2.56246788
146regulation of lymphocyte chemotaxis (GO:1901623)2.56231298
147establishment of protein localization to Golgi (GO:0072600)2.53379264
148interleukin-6-mediated signaling pathway (GO:0070102)2.50533744
149regulation of B cell activation (GO:0050864)2.49525137
150defense response to protozoan (GO:0042832)2.49482236
151negative regulation of organelle assembly (GO:1902116)2.48926188
152regulation of T cell receptor signaling pathway (GO:0050856)2.48631167
153positive T cell selection (GO:0043368)2.45947850
154T cell mediated immunity (GO:0002456)2.45330245
155regulation of tolerance induction (GO:0002643)2.45127925
156NLS-bearing protein import into nucleus (GO:0006607)2.43518853
157positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.42121312
158alpha-beta T cell differentiation involved in immune response (GO:0002293)2.41687263
159alpha-beta T cell activation involved in immune response (GO:0002287)2.41687263
160T cell differentiation involved in immune response (GO:0002292)2.41687263
161left/right pattern formation (GO:0060972)2.41148593
162regulation of T cell mediated cytotoxicity (GO:0001914)2.41141231
163negative regulation of lymphocyte mediated immunity (GO:0002707)2.39649177
164regulation of T-helper cell differentiation (GO:0045622)2.39442737
165negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.39368401
166positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.39240947
167cell adhesion mediated by integrin (GO:0033627)2.38839600
168negative regulation of T-helper cell differentiation (GO:0045623)2.38779718
169negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.38779718
170negative regulation of adaptive immune response (GO:0002820)2.38702547
171CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.37758556
172positive regulation of macrophage differentiation (GO:0045651)2.36360104
173regulation of centriole replication (GO:0046599)2.35996029
174regulation of necroptotic process (GO:0060544)2.34747167
175regulation of T cell tolerance induction (GO:0002664)2.34175360
176negative regulation of necroptotic process (GO:0060546)2.34033574
177spermatid nucleus differentiation (GO:0007289)2.32755992
178lipid translocation (GO:0034204)2.31967943
179phospholipid translocation (GO:0045332)2.31967943
180sequestering of actin monomers (GO:0042989)2.31249115
181positive regulation of macrophage activation (GO:0043032)2.30512246
182thymic T cell selection (GO:0045061)2.28340345
183positive regulation of tolerance induction (GO:0002645)2.27665863
184microtubule severing (GO:0051013)2.24901690
185regulation of podosome assembly (GO:0071801)2.24405979
186chaperone-mediated protein complex assembly (GO:0051131)2.23886454

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.04038531
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.52865320
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.99698868
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.86276395
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.25623866
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65210942
7GATA1_22025678_ChIP-Seq_K562_Human2.55598970
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35552227
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.30489316
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21378371
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19512049
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.19163758
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.16444771
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.10952392
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.06844198
16* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.93394341
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.90118579
18ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78515821
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72329569
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66742756
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57677223
22* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.52563682
23* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52012842
24PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51533390
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51227221
26TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.47495018
27VDR_24787735_ChIP-Seq_THP-1_Human1.46540441
28RUNX_20019798_ChIP-Seq_JUKART_Human1.46345470
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44896038
30ZNF274_21170338_ChIP-Seq_K562_Hela1.42547466
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.40218617
32TP53_16413492_ChIP-PET_HCT116_Human1.39373723
33GATA3_26560356_Chip-Seq_TH2_Human1.38998589
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38564759
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36425987
36MYB_26560356_Chip-Seq_TH2_Human1.34939289
37SCL_19346495_ChIP-Seq_HPC-7_Human1.31779033
38TCF7_22412390_ChIP-Seq_EML_Mouse1.30672327
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29107268
40CBP_20019798_ChIP-Seq_JUKART_Human1.29107268
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28864417
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.28576808
43* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.27484623
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.26267458
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.25663320
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24473944
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23262425
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22390134
49CJUN_26792858_Chip-Seq_BT549_Human1.21849622
50RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20236755
51EZH2_22144423_ChIP-Seq_EOC_Human1.19073495
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.18047868
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17112784
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.16297614
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15677187
56NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14517125
57MYB_26560356_Chip-Seq_TH1_Human1.14483849
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.14101869
59JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12262400
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11967308
61FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11496529
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10978999
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.10783460
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10552848
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.10329929
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.10258262
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09193007
68WDR5_24793694_ChIP-Seq_LNCAP_Human1.09057009
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08334693
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07613140
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06382275
72GATA1_19941826_ChIP-Seq_K562_Human1.05751602
73LXR_22158963_ChIP-Seq_LIVER_Mouse1.04111526
74GATA3_27048872_Chip-Seq_THYMUS_Human1.04072379
75KDM2B_26808549_Chip-Seq_REH_Human1.03687670
76TP63_17297297_ChIP-ChIP_HaCaT_Human1.03010557
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02079214
78GATA2_19941826_ChIP-Seq_K562_Human1.01787106
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01234804
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01069138
81* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00547037
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00469520
83STAT1_17558387_ChIP-Seq_HELA_Human1.00200634
84* TBX20_22080862_ChIP-Seq_HEART_Mouse0.99705594
85* TBX20_22328084_ChIP-Seq_HEART_Mouse0.99705594
86LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.99040588
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.98030719
88* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97734320
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97424770
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97249711
91* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97002228
92AHR_22903824_ChIP-Seq_MCF-7_Human0.95627181
93NFE2_27457419_Chip-Seq_LIVER_Mouse0.95492958
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95288380
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94455845
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93773090
97NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93773090
98* TP63_23658742_ChIP-Seq_EP156T_Human0.93416417
99CLOCK_20551151_ChIP-Seq_293T_Human0.93013373
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92563143
101BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91831136
102* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91109441
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90881400
104STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90880151
105PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90292096
106NANOG_18555785_Chip-Seq_ESCs_Mouse0.90291245
107STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90185883
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90148226
109GATA2_21666600_ChIP-Seq_HMVEC_Human0.89358067
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88669985
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88669985
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88004564
113SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87578436
114SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87578436
115* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87206774
116NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87111229
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87058277
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.86946172
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86636483
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86422747
121MAF_26560356_Chip-Seq_TH1_Human0.86067220
122TAF15_26573619_Chip-Seq_HEK293_Human0.85707620
123EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85645757
124GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85451799
125GBX2_23144817_ChIP-Seq_PC3_Human0.85449347
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85431450
127OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84975082
128* CDX2_22108803_ChIP-Seq_LS180_Human0.84842936
129PRDM14_20953172_ChIP-Seq_ESCs_Human0.84141449
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83635308
131RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83624381
132FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83609283
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83578537
134* ER_23166858_ChIP-Seq_MCF-7_Human0.83420837
135GATA1_26923725_Chip-Seq_HPCs_Mouse0.82913163
136SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82798160
137* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82731565
138* RUNX1_27514584_Chip-Seq_MCF-7_Human0.82551175
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82168751
140* STAT3_23295773_ChIP-Seq_U87_Human0.82013322
141* SMRT_27268052_Chip-Seq_Bcells_Human0.81524117
142BCAT_22108803_ChIP-Seq_LS180_Human0.80941034
143GF1_26923725_Chip-Seq_HPCs_Mouse0.80856212
144PU_27001747_Chip-Seq_BMDM_Mouse0.80639105
145* SPI1_23547873_ChIP-Seq_NB4_Human0.80455204
146E2F1_18555785_Chip-Seq_ESCs_Mouse0.80120137
147SALL1_21062744_ChIP-ChIP_HESCs_Human0.79795965
148CMYC_18555785_Chip-Seq_ESCs_Mouse0.79740874
149* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.79419703
150ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79396977
151* BRD4_25478319_ChIP-Seq_HGPS_Human0.79331664
152TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78929126
153ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78911457
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78392328
155* KDM2B_26808549_Chip-Seq_DND41_Human0.78379143
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.77943692

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive3.58028484
2MP0001929_abnormal_gametogenesis3.35995165
3MP0003300_gastrointestinal_ulcer2.85848112
4MP0000569_abnormal_digit_pigmentation2.80705317
5MP0008877_abnormal_DNA_methylation2.46624115
6MP0002138_abnormal_hepatobiliary_system2.42208365
7MP0003183_abnormal_peptide_metabolism2.28295684
8MP0005623_abnormal_meninges_morphology2.13092942
9MP0002148_abnormal_hypersensitivity_rea2.06175290
10MP0000685_abnormal_immune_system2.01798770
11MP0005410_abnormal_fertilization10.4103102
12MP0004510_myositis1.99506965
13MP0002166_altered_tumor_susceptibility1.98251451
14MP0002161_abnormal_fertility/fecundity1.93903909
15MP0006082_CNS_inflammation1.87634781
16MP0002210_abnormal_sex_determination1.84631796
17MP0009333_abnormal_splenocyte_physiolog1.83147044
18MP0009278_abnormal_bone_marrow1.80668537
19MP0003763_abnormal_thymus_physiology1.80608097
20MP0003091_abnormal_cell_migration1.74958943
21MP0010368_abnormal_lymphatic_system1.74333656
22MP0003705_abnormal_hypodermis_morpholog1.70436950
23MP0003656_abnormal_erythrocyte_physiolo1.68145013
24MP0002254_reproductive_system_inflammat1.66306356
25MP0000716_abnormal_immune_system1.66164364
26MP0005076_abnormal_cell_differentiation1.62920643
27MP0003866_abnormal_defecation1.59950305
28MP0004947_skin_inflammation1.59755623
29MP0010234_abnormal_vibrissa_follicle1.56696571
30MP0001145_abnormal_male_reproductive1.54520654
31MP0003045_fibrosis1.54037340
32MP0000465_gastrointestinal_hemorrhage1.51180752
33MP0005670_abnormal_white_adipose1.51043886
34MP0002009_preneoplasia1.48291313
35MP0003436_decreased_susceptibility_to1.48090094
36MP0005310_abnormal_salivary_gland1.47553083
37MP0005167_abnormal_blood-brain_barrier1.43822706
38MP0002006_tumorigenesis1.43064346
39MP0000689_abnormal_spleen_morphology1.41377789
40MP0001545_abnormal_hematopoietic_system1.39466059
41MP0005397_hematopoietic_system_phenotyp1.39466059
42MP0004808_abnormal_hematopoietic_stem1.36770068
43MP0005275_abnormal_skin_tensile1.36760417
44MP0000653_abnormal_sex_gland1.34913373
45MP0002405_respiratory_system_inflammati1.33792293
46MP0002722_abnormal_immune_system1.32800673
47MP0008438_abnormal_cutaneous_collagen1.32465494
48MP0003303_peritoneal_inflammation1.30057696
49MP0003195_calcinosis1.28665570
50MP0010352_gastrointestinal_tract_polyps1.28332885
51MP0003279_aneurysm1.26983588
52MP0001853_heart_inflammation1.26559819
53MP0001873_stomach_inflammation1.22618404
54MP0004381_abnormal_hair_follicle1.21621323
55MP0002429_abnormal_blood_cell1.21422405
56MP0003828_pulmonary_edema1.20174884
57MP0002928_abnormal_bile_duct1.20165481
58MP0003566_abnormal_cell_adhesion1.19909513
59MP0003724_increased_susceptibility_to1.19651581
60MP0003252_abnormal_bile_duct1.19554467
61MP0002653_abnormal_ependyma_morphology1.19491107
62MP0005023_abnormal_wound_healing1.11676284
63MP0010307_abnormal_tumor_latency1.10342165
64MP0001879_abnormal_lymphatic_vessel1.08641238
65MP0001502_abnormal_circadian_rhythm1.07665683
66MP0000604_amyloidosis1.07637674
67MP0001851_eye_inflammation1.06730849
68MP0008469_abnormal_protein_level1.06062747
69MP0008961_abnormal_basal_metabolism1.04780587
70MP0004272_abnormal_basement_membrane1.04614482
71MP0009785_altered_susceptibility_to1.02340801
72MP0000013_abnormal_adipose_tissue1.00548304
73MP0003868_abnormal_feces_composition1.00419526
74MP0005464_abnormal_platelet_physiology1.00333807
75MP0008004_abnormal_stomach_pH1.00300149
76MP0005503_abnormal_tendon_morphology0.99763393
77MP0001790_abnormal_immune_system0.99056544
78MP0005387_immune_system_phenotype0.99056544
79MP0002282_abnormal_trachea_morphology0.97701327
80MP0008995_early_reproductive_senescence0.96237399
81MP0001348_abnormal_lacrimal_gland0.95639378
82MP0003943_abnormal_hepatobiliary_system0.95150805
83MP0003448_altered_tumor_morphology0.91443950
84MP0001835_abnormal_antigen_presentation0.89988469
85MP0005000_abnormal_immune_tolerance0.89017706
86MP0001849_ear_inflammation0.88916336
87MP0003191_abnormal_cellular_cholesterol0.88004013
88MP0002723_abnormal_immune_serum0.86188446
89MP0002877_abnormal_melanocyte_morpholog0.85927826
90MP0008057_abnormal_DNA_replication0.85687069
91MP0001533_abnormal_skeleton_physiology0.84520522
92MP0001915_intracranial_hemorrhage0.84243703
93MP0004484_altered_response_of0.82658083
94MP0001765_abnormal_ion_homeostasis0.82500773
95MP0003115_abnormal_respiratory_system0.82114467
96MP0009115_abnormal_fat_cell0.81755889
97MP0005671_abnormal_response_to0.80653291
98MP0002998_abnormal_bone_remodeling0.79779430
99MP0009763_increased_sensitivity_to0.79730075
100MP0003172_abnormal_lysosome_physiology0.79196457
101MP0009764_decreased_sensitivity_to0.78776400
102MP0000733_abnormal_muscle_development0.78508549
103MP0001800_abnormal_humoral_immune0.78420485
104MP0010155_abnormal_intestine_physiology0.77374324
105MP0003453_abnormal_keratinocyte_physiol0.76627533
106MP0002332_abnormal_exercise_endurance0.76488799
107MP0002398_abnormal_bone_marrow0.75368761
108MP0002452_abnormal_antigen_presenting0.73996727
109MP0005166_decreased_susceptibility_to0.73960098
110MP0000858_altered_metastatic_potential0.73807757
111MP0006054_spinal_hemorrhage0.73187110
112MP0001819_abnormal_immune_cell0.72961067
113MP0001501_abnormal_sleep_pattern0.72685191
114MP0001958_emphysema0.72438827
115MP0000767_abnormal_smooth_muscle0.72389697
116MP0002419_abnormal_innate_immunity0.72330823
117MP0000609_abnormal_liver_physiology0.72160988
118MP0002420_abnormal_adaptive_immunity0.71786371
119MP0000703_abnormal_thymus_morphology0.71733027
120MP0000920_abnormal_myelination0.71437816
121MP0002168_other_aberrant_phenotype0.70449480
122MP0005647_abnormal_sex_gland0.69956868
123MP0001666_abnormal_nutrient_absorption0.69461184
124MP0005164_abnormal_response_to0.69106300
125MP0002060_abnormal_skin_morphology0.69017449
126MP0008260_abnormal_autophagy0.68936199
127MP0003690_abnormal_glial_cell0.67639519
128MP0001191_abnormal_skin_condition0.67628935
129MP0000003_abnormal_adipose_tissue0.67301262
130MP0000249_abnormal_blood_vessel0.66491487
131MP0004233_abnormal_muscle_weight0.65935678
132MP0005666_abnormal_adipose_tissue0.65740983
133MP0002925_abnormal_cardiovascular_devel0.64957882
134MP0010678_abnormal_skin_adnexa0.64288065
135MP0001845_abnormal_inflammatory_respons0.64045720
136MP0002139_abnormal_hepatobiliary_system0.63801239
137MP0002136_abnormal_kidney_physiology0.62836402
138MP0009840_abnormal_foam_cell0.62389037
139MP0003221_abnormal_cardiomyocyte_apopto0.62245275
140MP0002933_joint_inflammation0.61809404
141MP0008007_abnormal_cellular_replicative0.61474824
142MP0005645_abnormal_hypothalamus_physiol0.60962481
143MP0005257_abnormal_intraocular_pressure0.60431503
144MP0005025_abnormal_response_to0.59766277
145MP0005360_urolithiasis0.59422978
146MP0009765_abnormal_xenobiotic_induced0.59205959

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.48893033
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.01356068
3Absent/shortened dynein arms (HP:0200106)9.01356068
4Abnormal respiratory motile cilium physiology (HP:0012261)6.15365892
5Nasal polyposis (HP:0100582)6.04906911
6Abnormal respiratory epithelium morphology (HP:0012253)5.43702227
7Abnormal respiratory motile cilium morphology (HP:0005938)5.43702227
8Rhinitis (HP:0012384)5.35223557
9Chronic bronchitis (HP:0004469)5.30927478
10Abnormality of the nasal mucosa (HP:0000433)5.28952436
11Infertility (HP:0000789)5.00470269
12Abnormality of T cell number (HP:0011839)4.74743760
13Autoimmune hemolytic anemia (HP:0001890)4.65247284
14T lymphocytopenia (HP:0005403)4.63397065
15Abnormal ciliary motility (HP:0012262)4.39013529
16Chronic diarrhea (HP:0002028)4.18686579
17Bronchitis (HP:0012387)3.92104993
18Pulmonary infiltrates (HP:0002113)3.73752452
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.63648098
20Bronchiectasis (HP:0002110)3.52985462
21Abnormality of T cells (HP:0002843)3.32357595
22Mediastinal lymphadenopathy (HP:0100721)3.29988142
23Vasculitis (HP:0002633)3.24658260
24Nephronophthisis (HP:0000090)3.21543118
25Male infertility (HP:0003251)3.10878810
26Papilledema (HP:0001085)3.09285302
27Gastrointestinal infarctions (HP:0005244)3.03622845
28Tubular atrophy (HP:0000092)3.00884546
29Recurrent bronchitis (HP:0002837)2.99556669
30Recurrent viral infections (HP:0004429)2.97812182
31Autoimmune thrombocytopenia (HP:0001973)2.93876876
32Increased IgM level (HP:0003496)2.92576037
33Neoplasm of the tracheobronchial system (HP:0100552)2.85161967
34Joint swelling (HP:0001386)2.84805003
35Recurrent fungal infections (HP:0002841)2.84685803
36Menstrual irregularities (HP:0000858)2.83799795
37IgG deficiency (HP:0004315)2.79638369
38Abnormality of eosinophils (HP:0001879)2.78057929
39Recurrent cutaneous fungal infections (HP:0011370)2.77937576
40Chronic mucocutaneous candidiasis (HP:0002728)2.77937576
41Meningitis (HP:0001287)2.74685838
42Agammaglobulinemia (HP:0004432)2.71165773
43Elevated erythrocyte sedimentation rate (HP:0003565)2.67028043
44Heterotopia (HP:0002282)2.65792259
45Abnormality of T cell physiology (HP:0011840)2.65698656
46Recurrent otitis media (HP:0000403)2.64253847
47Abnormality of the renal medulla (HP:0100957)2.60934924
48Aortic aneurysm (HP:0004942)2.60389752
49Eosinophilia (HP:0001880)2.56296120
50Thyroiditis (HP:0100646)2.56286720
51Abnormality of the prostate (HP:0008775)2.54900763
52Stomach cancer (HP:0012126)2.49964208
53Abnormal spermatogenesis (HP:0008669)2.49695689
54IgA deficiency (HP:0002720)2.46089847
55Keratoconjunctivitis sicca (HP:0001097)2.44462669
56Hemoptysis (HP:0002105)2.43927682
57Abnormality of B cell number (HP:0010975)2.42753081
58Pulmonary embolism (HP:0002204)2.40209233
59Abnormality of the lower motor neuron (HP:0002366)2.39156731
60Tubulointerstitial abnormality (HP:0001969)2.37949172
61Tubulointerstitial fibrosis (HP:0005576)2.35021282
62Recurrent sinusitis (HP:0011108)2.34624658
63Recurrent bacterial skin infections (HP:0005406)2.29717042
64Impaired proprioception (HP:0010831)2.28919238
65Hemorrhage of the eye (HP:0011885)2.28586696
66Absent frontal sinuses (HP:0002688)2.27730447
67Leukocytosis (HP:0001974)2.27096415
68Gangrene (HP:0100758)2.25442843
69Pustule (HP:0200039)2.24848683
70Tubulointerstitial nephritis (HP:0001970)2.24275324
71Recurrent skin infections (HP:0001581)2.23516241
72Encephalitis (HP:0002383)2.21895934
73Granulocytopenia (HP:0001913)2.19635543
74Keratoconjunctivitis (HP:0001096)2.18882729
75B lymphocytopenia (HP:0010976)2.16731789
76Acute hepatic failure (HP:0006554)2.13228365
77Short nail (HP:0001799)2.12541601
78Spontaneous hematomas (HP:0007420)2.11715567
79Abnormality of macrophages (HP:0004311)2.11207307
80Severe combined immunodeficiency (HP:0004430)2.09212391
81Chest pain (HP:0100749)2.08818940
82Generalized hypopigmentation of hair (HP:0011358)2.07823557
83Segmental peripheral demyelination/remyelination (HP:0003481)2.06824415
84Exocrine pancreatic insufficiency (HP:0001738)2.06461885
85Decreased motor nerve conduction velocity (HP:0003431)2.04302302
86Molar tooth sign on MRI (HP:0002419)2.03435320
87Abnormality of midbrain morphology (HP:0002418)2.03435320
88Hypergammaglobulinemia (HP:0010702)2.02915737
89Optic neuritis (HP:0100653)2.02542757
90Retrobulbar optic neuritis (HP:0100654)2.02542757
91Azoospermia (HP:0000027)2.02343673
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97872857
93Arterial thrombosis (HP:0004420)1.96557034
94Fair hair (HP:0002286)1.96496151
95Degeneration of the lateral corticospinal tracts (HP:0002314)1.96224737
96Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96224737
97Gastrointestinal stroma tumor (HP:0100723)1.94981505
98Abnormality of dentin (HP:0010299)1.94772417
99Interstitial pulmonary disease (HP:0006530)1.94716814
100Gingivitis (HP:0000230)1.94693671
101Gonadotropin excess (HP:0000837)1.94184981
102Scanning speech (HP:0002168)1.94161950
103Abnormality of the pleura (HP:0002103)1.94051474
104Glucose intolerance (HP:0000833)1.92678078
105Abnormality of male internal genitalia (HP:0000022)1.92524351
106Orchitis (HP:0100796)1.92314488
107Osteolytic defects of the hand bones (HP:0009699)1.90022268
108Osteolytic defects of the phalanges of the hand (HP:0009771)1.90022268
109Myocardial infarction (HP:0001658)1.89484629
110Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.88996808
111Inflammation of the large intestine (HP:0002037)1.86418138
112Recurrent abscess formation (HP:0002722)1.86008688
113Abnormality of cells of the lymphoid lineage (HP:0012140)1.85357506
114Increased IgE level (HP:0003212)1.85319571
115Colitis (HP:0002583)1.84215381
116Chronic otitis media (HP:0000389)1.84163192
117Aortic dissection (HP:0002647)1.84005467
118Slow saccadic eye movements (HP:0000514)1.83699520
119Hypochromic anemia (HP:0001931)1.83112181
120Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82890599
121Abnormality of the renal cortex (HP:0011035)1.82534206
122Hypokalemic alkalosis (HP:0001949)1.82280491
123Hypoproteinemia (HP:0003075)1.82081614
124Cerebral aneurysm (HP:0004944)1.81211453
125Hyporeflexia of lower limbs (HP:0002600)1.79892426
126Ulnar claw (HP:0001178)1.79674774
127Arthralgia (HP:0002829)1.79356417
128Widely spaced teeth (HP:0000687)1.78540259
129Curly hair (HP:0002212)1.77875244
130Lymphopenia (HP:0001888)1.77813231
131Hypoplasia of dental enamel (HP:0006297)1.77437472
132Recurrent gram-negative bacterial infections (HP:0005420)1.76201457
133Thrombophlebitis (HP:0004418)1.75627122
134Abnormality of the fingertips (HP:0001211)1.74599408
135Pulmonary fibrosis (HP:0002206)1.74099437
136Fibular hypoplasia (HP:0003038)1.73853306
137Protrusio acetabuli (HP:0003179)1.73429786
138Subacute progressive viral hepatitis (HP:0006572)1.70717677
139Polycythemia (HP:0001901)1.70356684
140Cholecystitis (HP:0001082)1.69493219
141Abnormal gallbladder physiology (HP:0012438)1.69493219
142Eczematoid dermatitis (HP:0000976)1.69070351
143Increased CSF protein (HP:0002922)1.68964140
144Stage 5 chronic kidney disease (HP:0003774)1.68173994
145Difficulty climbing stairs (HP:0003551)1.68077350
146Impulsivity (HP:0100710)1.67831784
147Long toe (HP:0010511)1.66309727
148Conjunctival telangiectasia (HP:0000524)1.66161014
149Peritonitis (HP:0002586)1.64076158
150Milia (HP:0001056)1.63216951
151Stomatitis (HP:0010280)1.61403511
152Choroideremia (HP:0001139)1.60803227
153Truncal obesity (HP:0001956)1.56866754
154Myositis (HP:0100614)1.56359599
155Fatigue (HP:0012378)1.54878405
156Mitral valve prolapse (HP:0001634)1.53580827
157Esophageal varix (HP:0002040)1.51776494
158Aneurysm (HP:0002617)1.50343268
159Bell-shaped thorax (HP:0001591)1.50333780
160Vascular tortuosity (HP:0004948)1.49860129
161Striae distensae (HP:0001065)1.48805218
162Hand muscle atrophy (HP:0009130)1.48026084
163Bicuspid aortic valve (HP:0001647)1.47138757
164Arterial tortuosity (HP:0005116)1.46787366
165Upper motor neuron abnormality (HP:0002127)1.45790008
166Amyotrophic lateral sclerosis (HP:0007354)1.45213195
167Spontaneous abortion (HP:0005268)1.44177140
168Micronodular cirrhosis (HP:0001413)1.43498210
169Hematochezia (HP:0002573)1.41944367
170Increased density of long bones (HP:0006392)1.40783994
171Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.40500154
172Increased connective tissue (HP:0009025)1.39291236
173Papillary thyroid carcinoma (HP:0002895)1.39203396
174Alveolar cell carcinoma (HP:0006519)1.39190444
175Hypercholesterolemia (HP:0003124)1.39113839
176Hyperkalemia (HP:0002153)1.38883766
177Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.38585072
178Tetraparesis (HP:0002273)1.38044698
179Persistence of primary teeth (HP:0006335)1.36981266
180Distal upper limb amyotrophy (HP:0007149)1.36921352
181Upper limb amyotrophy (HP:0009129)1.36921352
182High pitched voice (HP:0001620)1.36650017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.76717656
2PDK35.76717656
3TESK14.73167899
4PDK23.78553821
5PRKD32.99945155
6ICK2.93210637
7TAOK32.62586854
8PTK2B2.48003584
9BMPR22.38321478
10PRPF4B2.37969641
11MAP3K142.36507728
12EIF2AK32.20105629
13FGFR42.16668992
14EPHB11.82450523
15MST41.81119905
16NEK91.76820057
17EPHA31.76816691
18FES1.74923691
19JAK31.74371687
20RIPK41.74252350
21BRD41.67137647
22CDK121.59149209
23RIPK11.50406204
24TXK1.48755959
25IRAK41.47395611
26NEK21.46258571
27PTK61.44176453
28WNK41.42656225
29STK31.40097002
30CHUK1.36748086
31TEC1.32822940
32FGFR31.32729216
33CSF1R1.32593791
34TBK11.32389602
35DYRK1B1.31871797
36SYK1.30665963
37PIK3CG1.29681118
38BCR1.28475185
39ZAP701.28028717
40LATS11.27624244
41STK241.26365034
42MAP4K11.24854636
43KIT1.22170891
44JAK11.21356114
45ITK1.20304596
46PIK3CA1.18372461
47SGK21.14356397
48MAP3K101.12031137
49SCYL21.11157572
50CAMKK21.10767218
51BTK1.09687958
52EEF2K1.09124574
53STK101.08181538
54TYK21.07680668
55STK381.07009446
56IKBKE1.03609692
57SIK21.01349305
58TTN1.01040902
59AKT30.99538166
60TYRO30.95740049
61TIE10.94543866
62FRK0.92937216
63NEK60.90320569
64MAPK110.89604074
65CASK0.89182395
66PDK10.88133882
67FER0.87696251
68CAMK1G0.86664477
69YES10.83298021
70RET0.81747454
71BLK0.80949811
72IRAK10.79980399
73FGR0.79688642
74TRIB30.79320536
75PTK20.78380897
76MTOR0.78115968
77PDGFRB0.76092164
78LYN0.72795380
79WNK10.72577958
80TGFBR20.72506742
81MARK30.71309931
82PDGFRA0.70832182
83PKN20.70588263
84STK390.70155466
85MAP3K30.69936448
86MAPK70.68673425
87ERBB30.67682162
88IKBKB0.67643736
89HIPK20.66568571
90MELK0.64708445
91CSK0.63832200
92NLK0.63612529
93FGFR10.62703860
94FGFR20.61991056
95KDR0.59818901
96JAK20.59480738
97RPS6KA40.57178763
98PAK20.56666697
99TNK20.56646441
100MAP3K120.54455448
101ACVR1B0.52456564
102CAMK1D0.52348857
103SGK4940.52054292
104SGK2230.52054292
105MAP2K60.51267465
106SGK10.50837802
107CAMKK10.48977360
108IRAK20.48969154
109MATK0.48795252
110PRKCQ0.48623102
111MST1R0.48351075
112MARK20.48167222
113HCK0.47722633
114PIM10.47343180
115MAP3K70.46086959
116CDK90.45866571
117GRK70.45663765
118MAP2K30.45220315
119MAP3K50.43577488
120RPS6KA50.42317600
121EGFR0.41644077
122ERN10.41484167
123MAPK120.40728801
124RPS6KB10.37677102
125ABL10.37016833
126MAP3K130.36568305
127PRKAA10.35982445
128TGFBR10.35673035
129BMX0.35167630
130TAOK20.34603944
131PDPK10.34385476
132TAOK10.33385171
133LCK0.32971961
134RPS6KA10.32971080
135MAPK150.32616078
136EPHB20.32255096
137INSR0.31736520
138STK38L0.31489410
139SGK30.31325610
140MAP3K10.30106440
141CDK60.30093542
142PRKAA20.29966813
143DMPK0.29081060
144MAP3K20.28971848
145SIK30.26810873
146ATM0.25268884
147TRPM70.24155377
148IGF1R0.24124789
149PRKCH0.23727059
150GSK3A0.22191811
151NUAK10.21777644

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053102.20088835
2T cell receptor signaling pathway_Homo sapiens_hsa046601.93179060
3Dorso-ventral axis formation_Homo sapiens_hsa043201.89655616
4Toxoplasmosis_Homo sapiens_hsa051451.84622982
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.70130838
6TNF signaling pathway_Homo sapiens_hsa046681.65277763
7Osteoclast differentiation_Homo sapiens_hsa043801.62020987
8Measles_Homo sapiens_hsa051621.60539851
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.52966856
10Fatty acid biosynthesis_Homo sapiens_hsa000611.49191161
11Glucagon signaling pathway_Homo sapiens_hsa049221.47331982
12Adipocytokine signaling pathway_Homo sapiens_hsa049201.39204210
13Legionellosis_Homo sapiens_hsa051341.37901699
14Circadian rhythm_Homo sapiens_hsa047101.37810215
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31817771
16Small cell lung cancer_Homo sapiens_hsa052221.31392019
17Allograft rejection_Homo sapiens_hsa053301.30431661
18Selenocompound metabolism_Homo sapiens_hsa004501.27564737
19Antigen processing and presentation_Homo sapiens_hsa046121.27318143
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26146898
21Rheumatoid arthritis_Homo sapiens_hsa053231.23992404
22Viral myocarditis_Homo sapiens_hsa054161.23016194
23Adherens junction_Homo sapiens_hsa045201.22721465
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19798601
25Leishmaniasis_Homo sapiens_hsa051401.19514621
26Malaria_Homo sapiens_hsa051441.15042233
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14409567
28Graft-versus-host disease_Homo sapiens_hsa053321.13433919
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13044859
30Influenza A_Homo sapiens_hsa051641.12690578
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12611644
32Pyruvate metabolism_Homo sapiens_hsa006201.10661713
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10073385
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09767012
35Chemokine signaling pathway_Homo sapiens_hsa040621.09626727
36Shigellosis_Homo sapiens_hsa051311.08554051
37Vitamin B6 metabolism_Homo sapiens_hsa007501.07248085
38Chronic myeloid leukemia_Homo sapiens_hsa052201.06628888
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.05265881
40Salmonella infection_Homo sapiens_hsa051321.04603702
41Pancreatic cancer_Homo sapiens_hsa052121.02951914
42Prolactin signaling pathway_Homo sapiens_hsa049171.01699343
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01368167
44VEGF signaling pathway_Homo sapiens_hsa043701.00955254
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00895461
46PPAR signaling pathway_Homo sapiens_hsa033200.99013455
47Insulin resistance_Homo sapiens_hsa049310.98865611
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98072574
49Acute myeloid leukemia_Homo sapiens_hsa052210.97558310
50B cell receptor signaling pathway_Homo sapiens_hsa046620.95875877
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.94480720
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94165369
53Hepatitis B_Homo sapiens_hsa051610.94104584
54Viral carcinogenesis_Homo sapiens_hsa052030.93918192
55Autoimmune thyroid disease_Homo sapiens_hsa053200.91394807
56Non-small cell lung cancer_Homo sapiens_hsa052230.91306922
57Focal adhesion_Homo sapiens_hsa045100.90200562
58Apoptosis_Homo sapiens_hsa042100.89444963
59Herpes simplex infection_Homo sapiens_hsa051680.86011487
60Renal cell carcinoma_Homo sapiens_hsa052110.85831370
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84996902
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84787451
63African trypanosomiasis_Homo sapiens_hsa051430.84691619
64HTLV-I infection_Homo sapiens_hsa051660.84483899
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83007043
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82561706
67ECM-receptor interaction_Homo sapiens_hsa045120.81345656
68Systemic lupus erythematosus_Homo sapiens_hsa053220.80566752
69Amoebiasis_Homo sapiens_hsa051460.79298089
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78743285
71Type II diabetes mellitus_Homo sapiens_hsa049300.77638977
72Complement and coagulation cascades_Homo sapiens_hsa046100.77173822
73Endocytosis_Homo sapiens_hsa041440.75632890
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75217895
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74112530
76Platelet activation_Homo sapiens_hsa046110.73618800
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.73295770
78Proteoglycans in cancer_Homo sapiens_hsa052050.72951435
79Pertussis_Homo sapiens_hsa051330.72383820
80MAPK signaling pathway_Homo sapiens_hsa040100.71799538
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.71424489
82Glycerolipid metabolism_Homo sapiens_hsa005610.70849843
83Renin secretion_Homo sapiens_hsa049240.69594674
84Primary immunodeficiency_Homo sapiens_hsa053400.69121974
85MicroRNAs in cancer_Homo sapiens_hsa052060.67792295
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67568145
87ABC transporters_Homo sapiens_hsa020100.66524643
88Hematopoietic cell lineage_Homo sapiens_hsa046400.66202314
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65368341
90HIF-1 signaling pathway_Homo sapiens_hsa040660.65300412
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64301090
92Inositol phosphate metabolism_Homo sapiens_hsa005620.63973330
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63612865
94Estrogen signaling pathway_Homo sapiens_hsa049150.62876116
95mTOR signaling pathway_Homo sapiens_hsa041500.62053755
96AMPK signaling pathway_Homo sapiens_hsa041520.60866452
97FoxO signaling pathway_Homo sapiens_hsa040680.59689016
98Prostate cancer_Homo sapiens_hsa052150.59007074
99Hepatitis C_Homo sapiens_hsa051600.58768189
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.58585648
101Staphylococcus aureus infection_Homo sapiens_hsa051500.55652246
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55446883
103ErbB signaling pathway_Homo sapiens_hsa040120.54654294
104TGF-beta signaling pathway_Homo sapiens_hsa043500.52968339
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52620538
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52582790
107Endometrial cancer_Homo sapiens_hsa052130.52485087
108Propanoate metabolism_Homo sapiens_hsa006400.51883124
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51688937
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.50975870
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50870686
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50565906
113Tuberculosis_Homo sapiens_hsa051520.49916788
114Type I diabetes mellitus_Homo sapiens_hsa049400.49784200
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49075862
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48653242
117Mineral absorption_Homo sapiens_hsa049780.48617030
118Oocyte meiosis_Homo sapiens_hsa041140.48402967
119Choline metabolism in cancer_Homo sapiens_hsa052310.43329622
120Epstein-Barr virus infection_Homo sapiens_hsa051690.41317874
121Long-term potentiation_Homo sapiens_hsa047200.41023396
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40742776
123Nitrogen metabolism_Homo sapiens_hsa009100.40197191
124Regulation of autophagy_Homo sapiens_hsa041400.37457897
125Pancreatic secretion_Homo sapiens_hsa049720.36927647
126GnRH signaling pathway_Homo sapiens_hsa049120.36433855
127Lysosome_Homo sapiens_hsa041420.34836672
128Phagosome_Homo sapiens_hsa041450.34394390
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33103502
130Prion diseases_Homo sapiens_hsa050200.32515250
131Glioma_Homo sapiens_hsa052140.31347518
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.30742424

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