RNF19B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protin is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)5.96259982
2regulation of vitamin D biosynthetic process (GO:0060556)4.72077773
3antigen processing and presentation of endogenous antigen (GO:0019883)4.54846435
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.40465183
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.40465183
6regulation of interleukin-12 biosynthetic process (GO:0045075)4.30128805
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.28889286
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.28889286
9modulation by symbiont of host immune response (GO:0052553)4.28889286
10positive regulation by symbiont of host defense response (GO:0052509)4.28889286
11modulation by symbiont of host defense response (GO:0052031)4.28889286
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.28889286
13response to muramyl dipeptide (GO:0032495)4.19154076
14fusion of sperm to egg plasma membrane (GO:0007342)4.16790463
15sperm motility (GO:0030317)4.00498012
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.92502961
17regulation of dendritic cell antigen processing and presentation (GO:0002604)3.87152181
18neutrophil activation involved in immune response (GO:0002283)3.84154027
19regulation of vitamin metabolic process (GO:0030656)3.82475009
20myeloid dendritic cell differentiation (GO:0043011)3.82023499
21positive regulation of interferon-alpha production (GO:0032727)3.80364913
22cell wall macromolecule catabolic process (GO:0016998)3.76370051
23cell wall macromolecule metabolic process (GO:0044036)3.76370051
24regulation of chronic inflammatory response (GO:0002676)3.73280276
25regulation of interferon-alpha production (GO:0032647)3.72068436
26positive regulation of type 2 immune response (GO:0002830)3.70753166
27detection of other organism (GO:0098543)3.68815500
28immunoglobulin mediated immune response (GO:0016064)3.68439910
29defense response to protozoan (GO:0042832)3.60815837
30positive regulation of antigen processing and presentation (GO:0002579)3.60452495
31detection of molecule of bacterial origin (GO:0032490)3.58022912
32regulation of interferon-beta biosynthetic process (GO:0045357)3.51081867
33response to peptidoglycan (GO:0032494)3.50966873
34positive regulation of gamma-delta T cell activation (GO:0046645)3.50961031
35macrophage activation involved in immune response (GO:0002281)3.47319480
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.47160960
37response to protozoan (GO:0001562)3.43995479
38acrosome assembly (GO:0001675)3.43566293
39regulation of cytokine secretion involved in immune response (GO:0002739)3.43385738
40negative regulation of cytokine production involved in immune response (GO:0002719)3.41409725
41interferon-gamma-mediated signaling pathway (GO:0060333)3.37581554
42detection of bacterium (GO:0016045)3.36309783
43granulocyte activation (GO:0036230)3.36240205
44multicellular organism reproduction (GO:0032504)3.35789984
45regulation of T-helper 2 cell differentiation (GO:0045628)3.34975903
46JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.33990937
47regulation of RIG-I signaling pathway (GO:0039535)3.33139215
48regulation of T-helper 1 cell differentiation (GO:0045625)3.32129034
49sperm-egg recognition (GO:0035036)3.32003300
50myeloid dendritic cell activation (GO:0001773)3.29588468
51positive regulation of natural killer cell differentiation (GO:0032825)3.29468711
52growth hormone receptor signaling pathway (GO:0060396)3.25883640
53negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.25201246
54regulation of interleukin-8 biosynthetic process (GO:0045414)3.24034756
55neutrophil activation (GO:0042119)3.23005258
56positive regulation of NF-kappaB import into nucleus (GO:0042346)3.22799627
57positive regulation of interleukin-12 production (GO:0032735)3.22504370
58cell-cell recognition (GO:0009988)3.21546803
59detection of external biotic stimulus (GO:0098581)3.20665582
60regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.20048973
61regulation of chemokine biosynthetic process (GO:0045073)3.19631048
62reproduction (GO:0000003)3.18591841
63regulation of T cell tolerance induction (GO:0002664)3.16540727
64acrosome reaction (GO:0007340)3.16101213
65production of molecular mediator involved in inflammatory response (GO:0002532)3.15587270
66dendritic cell differentiation (GO:0097028)3.15418385
67regulation of type 2 immune response (GO:0002828)3.14262875
68positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.09406701
69regulation of antigen processing and presentation (GO:0002577)3.08697179
70macrophage activation (GO:0042116)3.08108777
71positive regulation of heat generation (GO:0031652)3.05059432
72lipopolysaccharide-mediated signaling pathway (GO:0031663)3.02725345
73myeloid cell activation involved in immune response (GO:0002275)3.00876220
74regulation of interleukin-12 production (GO:0032655)3.00500771
75positive regulation of interferon-beta production (GO:0032728)3.00039529
76low-density lipoprotein particle clearance (GO:0034383)2.99078673
77regulation of T-helper cell differentiation (GO:0045622)2.97836675
78spermatid development (GO:0007286)2.96744057
79response to type I interferon (GO:0034340)2.95409881
80type I interferon signaling pathway (GO:0060337)2.95055511
81cellular response to type I interferon (GO:0071357)2.95055511
82plasma membrane fusion (GO:0045026)2.93017203
83regulation of tolerance induction (GO:0002643)2.91797576
84regulation of necroptotic process (GO:0060544)2.90922462
85detection of biotic stimulus (GO:0009595)2.89727811
86positive regulation of acute inflammatory response (GO:0002675)2.89394988
87positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.89315259
88positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.88374109
89negative regulation of T cell mediated immunity (GO:0002710)2.88201724
90regulation of fever generation (GO:0031620)2.87829715
91binding of sperm to zona pellucida (GO:0007339)2.85759066
92regulation of podosome assembly (GO:0071801)2.85608177
93regulation of integrin activation (GO:0033623)2.85046825
94negative regulation of viral genome replication (GO:0045071)2.84367213
95negative regulation of interleukin-12 production (GO:0032695)2.84320777
96branching involved in labyrinthine layer morphogenesis (GO:0060670)2.84250770
97cellular response to lipopolysaccharide (GO:0071222)2.83818725
98positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83806320
99regulation of NF-kappaB import into nucleus (GO:0042345)2.83261983
100regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.83040205
101cellular response to molecule of bacterial origin (GO:0071219)2.82991820
102positive regulation of T-helper cell differentiation (GO:0045624)2.82471027
103positive regulation of toll-like receptor signaling pathway (GO:0034123)2.81493735
104positive regulation of interleukin-6 production (GO:0032755)2.79742875
105positive regulation of cellular amide metabolic process (GO:0034250)2.79594205
106positive regulation of humoral immune response (GO:0002922)2.79093714
107leukocyte aggregation (GO:0070486)2.78598114
108cellular extravasation (GO:0045123)2.77523878
109regulation of type I interferon-mediated signaling pathway (GO:0060338)2.76646400
110cellular response to growth hormone stimulus (GO:0071378)2.74665040
111microglial cell activation (GO:0001774)2.74586095
112response to interferon-gamma (GO:0034341)2.74449049
113positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.74146371
114positive regulation of chemokine biosynthetic process (GO:0045080)2.73828581
115negative regulation of lipid storage (GO:0010888)2.73818501
116positive regulation of B cell differentiation (GO:0045579)2.71827525
117positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.71679179
118regulation of cholesterol storage (GO:0010885)2.68937980
119positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.67371378
120T-helper cell differentiation (GO:0042093)2.66455354
121CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.66455354
122tolerance induction (GO:0002507)2.64403465
123response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.63929611
124response to host immune response (GO:0052572)2.63929611
125T-helper 1 type immune response (GO:0042088)2.63344317
126negative regulation of cell killing (GO:0031342)2.62883033
127negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.62883033
128regulation of hypersensitivity (GO:0002883)2.61205323
129B cell mediated immunity (GO:0019724)2.61177846
130cellular response to interferon-gamma (GO:0071346)2.61078094
131membrane protein intracellular domain proteolysis (GO:0031293)2.60597591
132positive regulation of interleukin-2 production (GO:0032743)2.60151235
133positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.60124858
134regulation of response to interferon-gamma (GO:0060330)2.59791870
135sexual reproduction (GO:0019953)2.58398339
136antigen processing and presentation via MHC class Ib (GO:0002475)2.57990995
137piRNA metabolic process (GO:0034587)2.57895673
138negative regulation of inclusion body assembly (GO:0090084)2.56744398
139regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.55115036
140regulation of gamma-delta T cell activation (GO:0046643)2.55057491
141germinal center formation (GO:0002467)2.52413246
142modulation by symbiont of host cellular process (GO:0044068)2.52272876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.26419929
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.08039131
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.62537202
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.62364545
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.46910396
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.26052988
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.24491018
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.12147666
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.07527314
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02479450
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.97098704
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93293499
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.83171346
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.82221081
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.79334033
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.78347078
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71192009
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.47175737
19PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.33377243
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26830838
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14392504
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13422261
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97737534
24TCF7_22412390_ChIP-Seq_EML_Mouse1.93427902
25MYB_26560356_Chip-Seq_TH2_Human1.89007611
26* MAF_26560356_Chip-Seq_TH1_Human1.86454116
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.83026218
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79697977
29* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77936313
30MYB_26560356_Chip-Seq_TH1_Human1.73890715
31VDR_24787735_ChIP-Seq_THP-1_Human1.67170805
32RUNX_20019798_ChIP-Seq_JUKART_Human1.66623023
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65396822
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62880383
35VDR_24763502_ChIP-Seq_THP-1_Human1.55685438
36VDR_21846776_ChIP-Seq_THP-1_Human1.55602499
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53424819
38PU_27001747_Chip-Seq_BMDM_Mouse1.48515014
39GATA1_22025678_ChIP-Seq_K562_Human1.48463690
40* RUNX1_22412390_ChIP-Seq_EML_Mouse1.47880654
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43275254
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.42919117
43SPI1_23547873_ChIP-Seq_NB4_Human1.40074778
44* KDM2B_26808549_Chip-Seq_DND41_Human1.39932220
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38861873
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37187970
47MYC_22102868_ChIP-Seq_BL_Human1.36810180
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33599506
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33131022
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33094452
51SPI1_23127762_ChIP-Seq_K562_Human1.32660221
52* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32048295
53* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31954880
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.31713170
55* GATA3_27048872_Chip-Seq_THYMUS_Human1.31078588
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30155602
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28426910
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.24890351
59* UTX_26944678_Chip-Seq_JUKART_Human1.23452216
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22272003
61CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19057251
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.18780723
63* MAF_26560356_Chip-Seq_TH2_Human1.18658146
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18584756
65LXR_22292898_ChIP-Seq_THP-1_Human1.15131359
66SCL_19346495_ChIP-Seq_HPC-7_Human1.15054498
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12712527
68GATA1_19941826_ChIP-Seq_K562_Human1.12416140
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10263252
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.09719414
71ZNF263_19887448_ChIP-Seq_K562_Human1.08819161
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.08717085
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07885577
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07469642
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04512223
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03725049
77* GATA3_26560356_Chip-Seq_TH2_Human1.03350511
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03334945
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02892582
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02674307
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02135212
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00969046
83* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97422228
84* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97370002
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95398460
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95027362
87* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94181402
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93773011
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93258505
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91476790
91* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90954829
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90580405
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90525553
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90161334
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89980296
96* KDM2B_26808549_Chip-Seq_K562_Human0.89711467
97JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89337266
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88941511
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88779586
100SMRT_27268052_Chip-Seq_Bcells_Human0.87914377
101RACK7_27058665_Chip-Seq_MCF-7_Human0.87185682
102* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86128030
103EGR1_19032775_ChIP-ChIP_M12_Human0.85998803
104* KDM2B_26808549_Chip-Seq_JURKAT_Human0.85858349
105* NCOR1_26117541_ChIP-Seq_K562_Human0.84891650
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83024735
107SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83024735
108* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82290138
109* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81833598
110GATA2_19941826_ChIP-Seq_K562_Human0.81544974
111GATA2_21666600_ChIP-Seq_HMVEC_Human0.81296605
112LXR_22158963_ChIP-Seq_LIVER_Mouse0.80832124
113BCOR_27268052_Chip-Seq_Bcells_Human0.80151953
114* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79448251
115* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79343098
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78301775
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76790591
118STAT1_20625510_ChIP-Seq_HELA_Human0.76550435
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.75988429
120* UBF1/2_26484160_Chip-Seq_HMECs_Human0.75954181
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74992432
122* RXR_22158963_ChIP-Seq_LIVER_Mouse0.74856967
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74803926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.78057024
2MP0004510_myositis3.69106715
3MP0005410_abnormal_fertilization3.55755430
4MP0003303_peritoneal_inflammation3.43462235
5MP0003436_decreased_susceptibility_to3.31296068
6MP0002254_reproductive_system_inflammat3.28010668
7MP0000685_abnormal_immune_system2.97948241
8MP0009785_altered_susceptibility_to2.77629302
9MP0005387_immune_system_phenotype2.74293288
10MP0001790_abnormal_immune_system2.74293288
11MP0002138_abnormal_hepatobiliary_system2.64238486
12MP0005000_abnormal_immune_tolerance2.62028276
13MP0002148_abnormal_hypersensitivity_rea2.59880286
14MP0001800_abnormal_humoral_immune2.40152414
15MP0005451_abnormal_body_composition2.39555716
16MP0002419_abnormal_innate_immunity2.38306867
17MP0002452_abnormal_antigen_presenting2.33381775
18MP0005025_abnormal_response_to2.26946914
19MP0006082_CNS_inflammation2.25537049
20* MP0002723_abnormal_immune_serum2.20829046
21MP0005671_abnormal_response_to2.20170678
22MP0004947_skin_inflammation2.10940247
23MP0009278_abnormal_bone_marrow2.04100032
24MP0009840_abnormal_foam_cell2.02061980
25MP0008004_abnormal_stomach_pH2.01938001
26MP0000569_abnormal_digit_pigmentation1.98798611
27* MP0001819_abnormal_immune_cell1.93495689
28MP0003300_gastrointestinal_ulcer1.90469969
29* MP0002420_abnormal_adaptive_immunity1.90262326
30MP0005076_abnormal_cell_differentiation1.89765657
31MP0002405_respiratory_system_inflammati1.87126949
32MP0005310_abnormal_salivary_gland1.86789659
33MP0002166_altered_tumor_susceptibility1.84804960
34MP0002006_tumorigenesis1.83890627
35MP0005058_abnormal_lysosome_morphology1.81233181
36MP0010352_gastrointestinal_tract_polyps1.70105224
37MP0001853_heart_inflammation1.67397790
38MP0001533_abnormal_skeleton_physiology1.67218944
39MP0001545_abnormal_hematopoietic_system1.65804210
40MP0005397_hematopoietic_system_phenotyp1.65804210
41MP0003724_increased_susceptibility_to1.64425719
42MP0005464_abnormal_platelet_physiology1.62610446
43MP0002332_abnormal_exercise_endurance1.57559720
44MP0001845_abnormal_inflammatory_respons1.56885822
45MP0003705_abnormal_hypodermis_morpholog1.55309531
46MP0001348_abnormal_lacrimal_gland1.54947768
47* MP0003448_altered_tumor_morphology1.54939193
48MP0010155_abnormal_intestine_physiology1.53146959
49MP0000604_amyloidosis1.52482893
50MP0002398_abnormal_bone_marrow1.51735300
51MP0010307_abnormal_tumor_latency1.50639305
52MP0000716_abnormal_immune_system1.50635543
53MP0001873_stomach_inflammation1.44734764
54MP0008469_abnormal_protein_level1.37033878
55MP0009764_decreased_sensitivity_to1.36370590
56MP0002877_abnormal_melanocyte_morpholog1.33809124
57MP0008260_abnormal_autophagy1.32149874
58MP0003172_abnormal_lysosome_physiology1.29437524
59MP0003091_abnormal_cell_migration1.27557515
60MP0002139_abnormal_hepatobiliary_system1.27400672
61MP0002277_abnormal_respiratory_mucosa1.26380107
62MP0003453_abnormal_keratinocyte_physiol1.25033925
63MP0003191_abnormal_cellular_cholesterol1.22502637
64MP0009333_abnormal_splenocyte_physiolog1.22247215
65MP0002429_abnormal_blood_cell1.21132435
66MP0003690_abnormal_glial_cell1.21068064
67MP0000689_abnormal_spleen_morphology1.18822384
68MP0003566_abnormal_cell_adhesion1.18736635
69MP0002998_abnormal_bone_remodeling1.17871775
70MP0002722_abnormal_immune_system1.15240895
71MP0006054_spinal_hemorrhage1.08353246
72MP0003656_abnormal_erythrocyte_physiolo1.08140700
73MP0003195_calcinosis1.04631530
74MP0003075_altered_response_to1.00637678
75MP0003806_abnormal_nucleotide_metabolis1.00517617
76MP0001851_eye_inflammation1.00336586
77MP0001929_abnormal_gametogenesis0.96659918
78MP0000343_altered_response_to0.95773642
79MP0004808_abnormal_hematopoietic_stem0.95084180
80MP0003763_abnormal_thymus_physiology0.93762305
81MP0000465_gastrointestinal_hemorrhage0.93717040
82MP0003698_abnormal_male_reproductive0.90645836
83MP0009765_abnormal_xenobiotic_induced0.88719021
84MP0004883_abnormal_blood_vessel0.87761960
85* MP0000858_altered_metastatic_potential0.86942297
86MP0002009_preneoplasia0.85496111
87MP0001663_abnormal_digestive_system0.85449717
88MP0000703_abnormal_thymus_morphology0.84008874
89MP0002933_joint_inflammation0.83356675
90MP0000249_abnormal_blood_vessel0.81840256
91MP0005023_abnormal_wound_healing0.80502974
92MP0003045_fibrosis0.79782342
93MP0005167_abnormal_blood-brain_barrier0.79457049
94MP0005166_decreased_susceptibility_to0.76427884
95MP0000609_abnormal_liver_physiology0.75749823
96MP0005390_skeleton_phenotype0.73656523
97MP0001881_abnormal_mammary_gland0.73575196
98MP0008874_decreased_physiological_sensi0.72778715
99MP0009763_increased_sensitivity_to0.71332355
100MP0000733_abnormal_muscle_development0.69183015
101MP0000627_abnormal_mammary_gland0.68832774
102MP0003646_muscle_fatigue0.66714401
103MP0001542_abnormal_bone_strength0.64475176
104MP0005535_abnormal_body_temperature0.64115528
105MP0005165_increased_susceptibility_to0.63969534
106MP0001501_abnormal_sleep_pattern0.63364145
107MP0003866_abnormal_defecation0.62675669
108MP0000767_abnormal_smooth_muscle0.61702071
109MP0000920_abnormal_myelination0.61491323
110MP0003183_abnormal_peptide_metabolism0.61032645
111MP0002136_abnormal_kidney_physiology0.60781723
112MP0000490_abnormal_crypts_of0.60759698
113MP0003795_abnormal_bone_structure0.60096518
114MP0009115_abnormal_fat_cell0.59887726
115MP0003828_pulmonary_edema0.58228013
116MP0005164_abnormal_response_to0.57557749
117MP0005666_abnormal_adipose_tissue0.56926158
118MP0010234_abnormal_vibrissa_follicle0.56826746
119MP0001216_abnormal_epidermal_layer0.56459678
120MP0005257_abnormal_intraocular_pressure0.56166022
121MP0003221_abnormal_cardiomyocyte_apopto0.55109912
122MP0002163_abnormal_gland_morphology0.54484870
123MP0000371_diluted_coat_color0.53777852
124MP0004185_abnormal_adipocyte_glucose0.53370032
125MP0002019_abnormal_tumor_incidence0.53199365

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)5.44506842
2Eczematoid dermatitis (HP:0000976)5.12028674
3Recurrent abscess formation (HP:0002722)4.68938837
4Recurrent bacterial skin infections (HP:0005406)4.63893565
5Abnormality of the nasal mucosa (HP:0000433)4.61530203
6Orchitis (HP:0100796)4.50168866
7Retrobulbar optic neuritis (HP:0100654)4.41874812
8Optic neuritis (HP:0100653)4.41874812
9Myositis (HP:0100614)4.23429738
10Recurrent gram-negative bacterial infections (HP:0005420)3.98995718
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.97055917
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.96008856
13Absent/shortened dynein arms (HP:0200106)3.96008856
14Elevated erythrocyte sedimentation rate (HP:0003565)3.76847582
15Recurrent fungal infections (HP:0002841)3.72543750
16Mediastinal lymphadenopathy (HP:0100721)3.63113912
17Myocardial infarction (HP:0001658)3.60369910
18Tetraparesis (HP:0002273)3.55631741
19Abnormality of macrophages (HP:0004311)3.41479272
20Autoimmune thrombocytopenia (HP:0001973)3.37272471
21Arterial thrombosis (HP:0004420)3.24083977
22Gangrene (HP:0100758)3.17818014
23Vasculitis (HP:0002633)3.16982887
24Recurrent bronchitis (HP:0002837)3.16958316
25Recurrent viral infections (HP:0004429)3.15852803
26Dysostosis multiplex (HP:0000943)3.14724051
27Recurrent skin infections (HP:0001581)3.04789914
28Pulmonary infiltrates (HP:0002113)3.04047176
29Systemic lupus erythematosus (HP:0002725)3.02033116
30Chronic otitis media (HP:0000389)2.98932817
31Amyloidosis (HP:0011034)2.93943762
32Gastrointestinal infarctions (HP:0005244)2.86583752
33Encephalitis (HP:0002383)2.84348098
34Gingivitis (HP:0000230)2.82807757
35Increased cerebral lipofuscin (HP:0011813)2.78662976
36Peritonitis (HP:0002586)2.75483272
37Bronchitis (HP:0012387)2.75100345
38Stomatitis (HP:0010280)2.70939263
39Colitis (HP:0002583)2.70877593
40Chronic mucocutaneous candidiasis (HP:0002728)2.70440987
41Recurrent cutaneous fungal infections (HP:0011370)2.70440987
42Fatigue (HP:0012378)2.65984645
43Osteolytic defects of the hand bones (HP:0009699)2.63826140
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.63826140
45Keratoconjunctivitis (HP:0001096)2.63138761
46Keratoconjunctivitis sicca (HP:0001097)2.62473074
47Infertility (HP:0000789)2.61467661
48Episodic fever (HP:0001954)2.60991591
49Interstitial pulmonary disease (HP:0006530)2.59686379
50Hematochezia (HP:0002573)2.57477479
51Disinhibition (HP:0000734)2.56936606
52T lymphocytopenia (HP:0005403)2.53818191
53Rhinitis (HP:0012384)2.52538903
54Increased IgE level (HP:0003212)2.51538429
55Thick nail (HP:0001805)2.50309134
56Periodontitis (HP:0000704)2.49788207
57Male infertility (HP:0003251)2.47121198
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45353762
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45353762
60Abnormality of polysaccharide metabolism (HP:0011012)2.45353762
61Abnormality of T cell number (HP:0011839)2.44932957
62Mutism (HP:0002300)2.44422486
63Abnormal respiratory motile cilium physiology (HP:0012261)2.43473836
64Spontaneous hematomas (HP:0007420)2.42227463
65Polycythemia (HP:0001901)2.42167029
66Increased serum ferritin (HP:0003281)2.41378658
67Cellulitis (HP:0100658)2.39781393
68Pulmonary embolism (HP:0002204)2.39203473
69Malnutrition (HP:0004395)2.36946337
70Abnormality of the pleura (HP:0002103)2.34721902
71Hypergammaglobulinemia (HP:0010702)2.30523230
72Autoimmune hemolytic anemia (HP:0001890)2.30276347
73Leukocytosis (HP:0001974)2.29727139
74Mucopolysacchariduria (HP:0008155)2.29532084
75Urinary glycosaminoglycan excretion (HP:0003541)2.29532084
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.28825648
77Abnormal respiratory motile cilium morphology (HP:0005938)2.28431265
78Abnormal respiratory epithelium morphology (HP:0012253)2.28431265
79Nuclear cataract (HP:0100018)2.27181772
80Increased IgM level (HP:0003496)2.25866698
81Esophageal varix (HP:0002040)2.25557784
82Neurofibrillary tangles (HP:0002185)2.23725113
83Inflammation of the large intestine (HP:0002037)2.23356188
84Bronchiectasis (HP:0002110)2.23107035
85Hemoptysis (HP:0002105)2.22925660
86Pustule (HP:0200039)2.22694292
87Basal ganglia calcification (HP:0002135)2.21602848
88Chronic obstructive pulmonary disease (HP:0006510)2.21585686
89Obstructive lung disease (HP:0006536)2.21585686
90Porencephaly (HP:0002132)2.19261312
91Acne (HP:0001061)2.18821014
92Joint swelling (HP:0001386)2.18507230
93Increased neuronal autofluorescent lipopigment (HP:0002074)2.18312429
94Axonal loss (HP:0003447)2.15865660
95Upper motor neuron abnormality (HP:0002127)2.15804084
96Vertigo (HP:0002321)2.15227267
97Progressive neurologic deterioration (HP:0002344)2.14800168
98Glomerulonephritis (HP:0000099)2.13665062
99Glomerulopathy (HP:0100820)2.12911752
100Parakeratosis (HP:0001036)2.12321942
101Chronic bronchitis (HP:0004469)2.12313388
102Cortical dysplasia (HP:0002539)2.12270404
103Loss of speech (HP:0002371)2.12016802
104Purpura (HP:0000979)2.10638152
105Abnormality of the endocardium (HP:0004306)2.09559152
106Prostate neoplasm (HP:0100787)2.09356056
107Gastrointestinal inflammation (HP:0004386)2.08470485
108Petechiae (HP:0000967)2.05898548
109Keratitis (HP:0000491)2.04278565
110Gingival bleeding (HP:0000225)2.02725487
111Abnormality of glycolipid metabolism (HP:0010969)2.00265266
112Abnormality of liposaccharide metabolism (HP:0010968)2.00265266
113Abnormality of glycosphingolipid metabolism (HP:0004343)2.00265266
114Chronic sinusitis (HP:0011109)2.00144742
115Premature loss of primary teeth (HP:0006323)1.98772900
116Global brain atrophy (HP:0002283)1.98520811
117Gastrointestinal stroma tumor (HP:0100723)1.97078559
118Abnormality of iron homeostasis (HP:0011031)1.96196717
119Meningitis (HP:0001287)1.95669755
120Neuronal loss in central nervous system (HP:0002529)1.95179105
121Emphysema (HP:0002097)1.94877781
122Recurrent sinusitis (HP:0011108)1.94452966
123Thrombocytosis (HP:0001894)1.93361586
124Arthralgia (HP:0002829)1.93107143
125Apathy (HP:0000741)1.92549275
126Abnormality of the pericardium (HP:0001697)1.89863032
127Vacuolated lymphocytes (HP:0001922)1.89401769
128Nephritis (HP:0000123)1.88874393
129Abnormal delayed hypersensitivity skin test (HP:0002963)1.88801442
130Anorexia (HP:0002039)1.88644197
131Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88324598
132Polyneuropathy (HP:0001271)1.86306430
133Absent frontal sinuses (HP:0002688)1.84980028
134Frequent falls (HP:0002359)1.84660171
135Hemorrhage of the eye (HP:0011885)1.83064529
136Chest pain (HP:0100749)1.82365050
137Urticaria (HP:0001025)1.81098369
138Osteomyelitis (HP:0002754)1.79806478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.62034326
2TBK13.43391246
3TYK23.36419591
4RIPK42.89337060
5JAK32.84638953
6IKBKB2.78297439
7PRPF4B2.67568743
8TESK12.55197382
9JAK12.36018424
10IKBKE2.29932170
11TAOK22.27926923
12GRK72.26465766
13CHUK2.21251682
14TRIB32.15910504
15MAP4K12.13698712
16MAP3K132.04600456
17BLK1.98482675
18EPHB11.95667429
19PDK41.94069244
20PDK31.94069244
21FGFR41.84788937
22ICK1.82327767
23IRAK31.78782663
24ERN11.71682017
25BMPR21.62036452
26PDK21.60529309
27DDR21.57755551
28TXK1.55162582
29IRAK21.54415512
30KIT1.51733407
31RIPK11.46957016
32IRAK41.45514199
33NME21.37529944
34CDK121.36457052
35PIM11.35277649
36EPHA31.34177000
37MAP3K101.32733334
38BMX1.32533950
39ZAP701.32229676
40JAK21.29380327
41CDC42BPA1.29248563
42PRKD31.29091743
43CSF1R1.29001457
44STK31.28267618
45FGFR31.26544096
46PIM21.20582618
47RPS6KA41.18537162
48TAOK31.15932360
49PTK61.14340007
50SIK31.11235737
51CSK1.09909541
52NEK21.05770066
53MAP3K31.04656625
54HCK1.03429058
55STK101.02128809
56FES0.99944775
57SYK0.93189144
58PTK2B0.90407690
59NEK90.86404472
60MAP2K30.84769738
61TGFBR20.83352004
62PDK10.79587286
63TNK20.77983587
64DYRK1B0.77434732
65IRAK10.77304574
66EEF2K0.77029587
67MAP3K50.76928755
68LCK0.76121054
69TTN0.74641206
70ALK0.73039391
71CDK60.72553910
72MARK30.72539060
73PKN20.68336432
74HIPK20.67511083
75SIK20.66352067
76TAOK10.63801061
77MOS0.63093425
78PDPK10.62587833
79MARK20.61717317
80PRKAA20.60015192
81EGFR0.59789993
82BTK0.57118669
83GRK60.57065961
84MAP2K60.56152575
85FGR0.55696981
86MAPKAPK20.55502344
87STK380.52311530
88ABL10.52302720
89ITK0.51943470
90ACVR1B0.51936001
91YES10.51346352
92RET0.50804108
93RPS6KA10.50659441
94SIK10.49624429
95MAP3K20.49308217
96MTOR0.48340896
97ADRBK20.47797173
98MAPK70.47269838
99LRRK20.46961009
100DAPK20.45634475
101DYRK30.45319492
102CLK10.43553292
103ABL20.43218345
104PDGFRB0.43026444
105MAP3K10.43001957
106GSK3A0.42378944
107STK240.40259447
108PRKD20.39713662
109MAP3K110.39608071
110LYN0.38605996
111MAP3K90.38602222
112TESK20.37191250
113PAK40.36911975
114PRKCD0.36284963
115FYN0.36182334
116MAP3K60.35939001
117CDK40.35034386
118KSR20.34859049
119STK40.34370994
120TYRO30.34295522
121ARAF0.34269701
122LATS20.32922364
123FLT30.32197774
124MELK0.31870214
125KSR10.31477846
126MATK0.31112990
127NLK0.30829340
128RPS6KL10.29293348
129RPS6KC10.29293348
130CAMK1D0.28740092
131PKN10.28686333
132PAK20.28588118
133SGK30.28101595
134MAPK40.27013194

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.92389794
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.89200909
3Osteoclast differentiation_Homo sapiens_hsa043802.64090038
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.33912714
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.27541974
6TNF signaling pathway_Homo sapiens_hsa046682.26350616
7Allograft rejection_Homo sapiens_hsa053302.22931027
8Measles_Homo sapiens_hsa051622.19694616
9Graft-versus-host disease_Homo sapiens_hsa053322.19380117
10Staphylococcus aureus infection_Homo sapiens_hsa051502.14788298
11Legionellosis_Homo sapiens_hsa051342.12428087
12Toxoplasmosis_Homo sapiens_hsa051452.10810338
13Antigen processing and presentation_Homo sapiens_hsa046121.95015499
14B cell receptor signaling pathway_Homo sapiens_hsa046621.91157201
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90493091
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.83880784
17Influenza A_Homo sapiens_hsa051641.79702796
18Tuberculosis_Homo sapiens_hsa051521.76604149
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75497392
20Malaria_Homo sapiens_hsa051441.71269966
21Apoptosis_Homo sapiens_hsa042101.70537895
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.68470601
23Pertussis_Homo sapiens_hsa051331.66095471
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.57906287
25Herpes simplex infection_Homo sapiens_hsa051681.47625119
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39253087
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35837227
28Rheumatoid arthritis_Homo sapiens_hsa053231.34844830
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31045983
30Shigellosis_Homo sapiens_hsa051311.30686345
31African trypanosomiasis_Homo sapiens_hsa051431.30411238
32Chemokine signaling pathway_Homo sapiens_hsa040621.29859775
33Asthma_Homo sapiens_hsa053101.27824558
34Type I diabetes mellitus_Homo sapiens_hsa049401.27344373
35T cell receptor signaling pathway_Homo sapiens_hsa046601.27205687
36Acute myeloid leukemia_Homo sapiens_hsa052211.26553879
37Salmonella infection_Homo sapiens_hsa051321.22377299
38Adipocytokine signaling pathway_Homo sapiens_hsa049201.21860394
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17021483
40Chronic myeloid leukemia_Homo sapiens_hsa052201.14352771
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.13884013
42Prolactin signaling pathway_Homo sapiens_hsa049171.12570516
43Hepatitis B_Homo sapiens_hsa051611.11032913
44Small cell lung cancer_Homo sapiens_hsa052221.07368619
45Dorso-ventral axis formation_Homo sapiens_hsa043201.06040243
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05190484
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04753447
48Viral myocarditis_Homo sapiens_hsa054161.04059211
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03312363
50Lysosome_Homo sapiens_hsa041421.02701961
51Autoimmune thyroid disease_Homo sapiens_hsa053201.02097002
52Hematopoietic cell lineage_Homo sapiens_hsa046401.01400298
53Primary immunodeficiency_Homo sapiens_hsa053400.99395464
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98198839
55Hepatitis C_Homo sapiens_hsa051600.97933016
56Epstein-Barr virus infection_Homo sapiens_hsa051690.97854310
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91181985
58Amoebiasis_Homo sapiens_hsa051460.87321897
59Pancreatic cancer_Homo sapiens_hsa052120.86872079
60Phagosome_Homo sapiens_hsa041450.84007201
61VEGF signaling pathway_Homo sapiens_hsa043700.83878116
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.81664205
63Insulin resistance_Homo sapiens_hsa049310.81548841
64Viral carcinogenesis_Homo sapiens_hsa052030.80072921
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78783843
66Type II diabetes mellitus_Homo sapiens_hsa049300.78461797
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77822063
68mTOR signaling pathway_Homo sapiens_hsa041500.76385403
69Bladder cancer_Homo sapiens_hsa052190.74814670
70HIF-1 signaling pathway_Homo sapiens_hsa040660.74690295
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69561068
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.66851183
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63953129
74HTLV-I infection_Homo sapiens_hsa051660.62193485
75p53 signaling pathway_Homo sapiens_hsa041150.58531144
76Endocytosis_Homo sapiens_hsa041440.58530470
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56461499
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54954514
79MAPK signaling pathway_Homo sapiens_hsa040100.53521148
80Notch signaling pathway_Homo sapiens_hsa043300.53235202
81Other glycan degradation_Homo sapiens_hsa005110.51238454
82MicroRNAs in cancer_Homo sapiens_hsa052060.50106416
83Prion diseases_Homo sapiens_hsa050200.49426464
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48560825
85FoxO signaling pathway_Homo sapiens_hsa040680.47162797
86Platelet activation_Homo sapiens_hsa046110.46889793
87Sphingolipid metabolism_Homo sapiens_hsa006000.45494889
88Renal cell carcinoma_Homo sapiens_hsa052110.44577937
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44179960
90Proteoglycans in cancer_Homo sapiens_hsa052050.42635043
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41585062
92Fatty acid biosynthesis_Homo sapiens_hsa000610.40658312
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38575535
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37230142
95Inositol phosphate metabolism_Homo sapiens_hsa005620.37124161
96GnRH signaling pathway_Homo sapiens_hsa049120.35808023
97Complement and coagulation cascades_Homo sapiens_hsa046100.35065468
98Collecting duct acid secretion_Homo sapiens_hsa049660.34666690
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34350275
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.33695253
101Estrogen signaling pathway_Homo sapiens_hsa049150.33435555
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.33417960
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31968693
104Prostate cancer_Homo sapiens_hsa052150.31799932
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.30923137
106Non-small cell lung cancer_Homo sapiens_hsa052230.30155965
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29962016
108ErbB signaling pathway_Homo sapiens_hsa040120.29588039
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28175485
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27205738
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24103704
112Endometrial cancer_Homo sapiens_hsa052130.22934172
113Mineral absorption_Homo sapiens_hsa049780.21888350
114Insulin signaling pathway_Homo sapiens_hsa049100.19268927
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19028244
116Galactose metabolism_Homo sapiens_hsa000520.17556256

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