RNF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.58825017
2DNA double-strand break processing (GO:0000729)4.34122862
3nuclear pore organization (GO:0006999)4.25264914
4metaphase plate congression (GO:0051310)4.18599089
5nuclear pore complex assembly (GO:0051292)4.07106224
6protein localization to kinetochore (GO:0034501)3.98872027
7DNA damage response, detection of DNA damage (GO:0042769)3.87587071
8establishment of chromosome localization (GO:0051303)3.80468142
9DNA unwinding involved in DNA replication (GO:0006268)3.77123779
10CENP-A containing nucleosome assembly (GO:0034080)3.76092034
11kinetochore organization (GO:0051383)3.75573616
12chromatin remodeling at centromere (GO:0031055)3.71036951
13regulation of spindle organization (GO:0090224)3.65234137
14DNA replication-independent nucleosome organization (GO:0034724)3.61327506
15DNA replication-independent nucleosome assembly (GO:0006336)3.61327506
16cornea development in camera-type eye (GO:0061303)3.58665773
17regulation of mitotic spindle checkpoint (GO:1903504)3.55129595
18mitotic nuclear envelope disassembly (GO:0007077)3.53498026
19mitotic chromosome condensation (GO:0007076)3.53484359
20DNA replication initiation (GO:0006270)3.51487354
21spindle checkpoint (GO:0031577)3.49963063
22regulation of development, heterochronic (GO:0040034)3.47722410
23purine nucleobase biosynthetic process (GO:0009113)3.47573119
24negative regulation of sister chromatid segregation (GO:0033046)3.46561308
25negative regulation of mitotic sister chromatid separation (GO:2000816)3.46561308
26negative regulation of mitotic sister chromatid segregation (GO:0033048)3.46561308
27negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.46561308
28negative regulation of chromosome segregation (GO:0051985)3.46233607
29mitotic spindle assembly checkpoint (GO:0007094)3.45860754
30spindle assembly checkpoint (GO:0071173)3.44828151
31proteasome assembly (GO:0043248)3.43483374
32IMP biosynthetic process (GO:0006188)3.39247549
33nucleobase biosynthetic process (GO:0046112)3.39172839
34negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.39067226
35DNA strand elongation involved in DNA replication (GO:0006271)3.38424431
36protein localization to chromosome, centromeric region (GO:0071459)3.37910446
37mitotic spindle checkpoint (GO:0071174)3.37872048
38cullin deneddylation (GO:0010388)3.37197708
39pyrimidine nucleobase catabolic process (GO:0006208)3.36953683
40regulation of mitotic metaphase/anaphase transition (GO:0030071)3.36334689
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.35656615
42DNA replication checkpoint (GO:0000076)3.33714970
43neural tube formation (GO:0001841)3.33009511
44DNA strand elongation (GO:0022616)3.32299802
45DNA replication-dependent nucleosome assembly (GO:0006335)3.32241261
46DNA replication-dependent nucleosome organization (GO:0034723)3.32241261
47regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.31471840
48mitotic sister chromatid segregation (GO:0000070)3.30993437
49regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.30776230
50membrane disassembly (GO:0030397)3.30179956
51nuclear envelope disassembly (GO:0051081)3.30179956
52kinetochore assembly (GO:0051382)3.29228614
53histone exchange (GO:0043486)3.28735974
54sister chromatid segregation (GO:0000819)3.28601953
55regulation of telomere maintenance via telomerase (GO:0032210)3.28420939
56regulation of chromosome segregation (GO:0051983)3.26208624
57regulation of helicase activity (GO:0051095)3.25368327
58regulation of sister chromatid segregation (GO:0033045)3.23153616
59regulation of mitotic sister chromatid separation (GO:0010965)3.23153616
60regulation of mitotic sister chromatid segregation (GO:0033047)3.23153616
61regulation of timing of cell differentiation (GO:0048505)3.21213439
62attachment of spindle microtubules to kinetochore (GO:0008608)3.20895168
63regulation of sister chromatid cohesion (GO:0007063)3.18426567
64ribosome assembly (GO:0042255)3.16383307
65pore complex assembly (GO:0046931)3.14350010
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10829339
67ATP-dependent chromatin remodeling (GO:0043044)3.08897247
68protein deneddylation (GO:0000338)3.08764618
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.06502036
70protein localization to chromosome (GO:0034502)3.04362411
71dosage compensation (GO:0007549)3.03870756
72formation of translation preinitiation complex (GO:0001731)3.02734581
73mitotic recombination (GO:0006312)3.02030631
74mitotic sister chromatid cohesion (GO:0007064)3.01470863
75DNA catabolic process, exonucleolytic (GO:0000738)3.01363800
76telomere maintenance via recombination (GO:0000722)3.01253965
77maturation of 5.8S rRNA (GO:0000460)3.00362449
78positive regulation of chromosome segregation (GO:0051984)2.99338740
79telomere maintenance via semi-conservative replication (GO:0032201)2.99066133
80positive regulation of mitotic sister chromatid separation (GO:1901970)2.97990279
81positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.97990279
82positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.97990279
83meiotic chromosome segregation (GO:0045132)2.97253704
84regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96780656
85regulation of centriole replication (GO:0046599)2.96111024
86replication fork processing (GO:0031297)2.95796758
87histone H2A acetylation (GO:0043968)2.95684830
88negative regulation of DNA recombination (GO:0045910)2.95459983
89DNA topological change (GO:0006265)2.95363777
90presynaptic membrane assembly (GO:0097105)2.95068154
91paraxial mesoderm development (GO:0048339)2.94476232
92DNA deamination (GO:0045006)2.94444084
93somatic hypermutation of immunoglobulin genes (GO:0016446)2.93945265
94somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93945265
95telomere maintenance via telomere lengthening (GO:0010833)2.93777844
96regulation of double-strand break repair via homologous recombination (GO:0010569)2.93393074
97synapsis (GO:0007129)2.93005681
98RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.91739813
99establishment of protein localization to mitochondrial membrane (GO:0090151)2.91425659
100chromosome segregation (GO:0007059)2.89725442
101monoubiquitinated protein deubiquitination (GO:0035520)2.88785994
102regulation of mitotic spindle organization (GO:0060236)2.88600451
103RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88416025
104tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88416025
105L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.87264845
106IMP metabolic process (GO:0046040)2.85268721
107DNA duplex unwinding (GO:0032508)2.85256344
108DNA geometric change (GO:0032392)2.84866514
109chromatin assembly or disassembly (GO:0006333)2.84706834
110negative regulation of histone methylation (GO:0031061)2.84294030
111negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.82885588
112regulation of centrosome cycle (GO:0046605)2.82609709
113regulation of hexokinase activity (GO:1903299)2.80654350
114regulation of glucokinase activity (GO:0033131)2.80654350
115regulation of meiosis I (GO:0060631)2.80380220
116ribosome biogenesis (GO:0042254)2.80101509
117telomere maintenance via telomerase (GO:0007004)2.79060733
118spliceosomal snRNP assembly (GO:0000387)2.78636952
119RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.78624514
120mRNA splicing, via spliceosome (GO:0000398)2.78624514
121RNA splicing, via transesterification reactions (GO:0000375)2.78611323
122histone mRNA metabolic process (GO:0008334)2.78601511
123postreplication repair (GO:0006301)2.76917480
124hindbrain development (GO:0030902)2.76016266
125intra-S DNA damage checkpoint (GO:0031573)2.76005022
126protein K6-linked ubiquitination (GO:0085020)2.75939689
127negative regulation of mitosis (GO:0045839)2.75817746
128maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.73578479
129mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72789025
130mitochondrial respiratory chain complex I assembly (GO:0032981)2.72789025
131NADH dehydrogenase complex assembly (GO:0010257)2.72789025
132negative regulation of DNA-dependent DNA replication (GO:2000104)2.72596643
133water-soluble vitamin biosynthetic process (GO:0042364)2.72362240
134termination of RNA polymerase III transcription (GO:0006386)2.70408108
135transcription elongation from RNA polymerase III promoter (GO:0006385)2.70408108
136folic acid-containing compound biosynthetic process (GO:0009396)2.70060312
137somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.69434718
138somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.69434718
139isotype switching (GO:0045190)2.69434718
140nonmotile primary cilium assembly (GO:0035058)2.67464919
141regulation of nuclear cell cycle DNA replication (GO:0033262)2.66877546
142regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.66605585
143response to pheromone (GO:0019236)2.65174572
144nucleobase catabolic process (GO:0046113)2.64550487
145cilium morphogenesis (GO:0060271)2.64436759
146positive regulation of mitochondrial fission (GO:0090141)2.61069962
147intraciliary transport (GO:0042073)2.60731177
148dorsal/ventral axis specification (GO:0009950)2.58210544
149protein K11-linked ubiquitination (GO:0070979)2.57324050
150microtubule anchoring (GO:0034453)2.54933903
151protein complex biogenesis (GO:0070271)2.53895789
152protein localization to cilium (GO:0061512)2.52292744
153regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.51554118
154recombinational repair (GO:0000725)2.50365638
155negative regulation of transcription regulatory region DNA binding (GO:2000678)2.49990829
156establishment of integrated proviral latency (GO:0075713)2.49901142
157resolution of meiotic recombination intermediates (GO:0000712)2.49762314
158negative regulation of telomere maintenance (GO:0032205)2.48839714
159respiratory chain complex IV assembly (GO:0008535)2.48786031
160head development (GO:0060322)2.48484506
161pituitary gland development (GO:0021983)2.46712115
162organelle disassembly (GO:1903008)2.46149985
163centriole replication (GO:0007099)2.45661372
164mitochondrial respiratory chain complex assembly (GO:0033108)2.45447116
165chaperone-mediated protein transport (GO:0072321)2.43831017
166double-strand break repair via homologous recombination (GO:0000724)2.43227016
167DNA ligation (GO:0006266)2.41507667
168protein neddylation (GO:0045116)2.39842652
169presynaptic membrane organization (GO:0097090)2.37642103
170regulation of telomere maintenance (GO:0032204)2.36696899
171regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.36365003
172transcription from RNA polymerase III promoter (GO:0006383)2.35499908
173amino acid salvage (GO:0043102)2.34515753
174L-methionine salvage (GO:0071267)2.34515753
175L-methionine biosynthetic process (GO:0071265)2.34515753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.96958411
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.91474826
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.18893877
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.94168108
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.52048557
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.01187786
7ZNF274_21170338_ChIP-Seq_K562_Hela2.93968984
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.90373238
9IGF1R_20145208_ChIP-Seq_DFB_Human2.90330378
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.89664441
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73303011
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70221698
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67625099
14* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.61483085
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.57197933
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.56983230
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.56919102
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.54703112
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.51651042
20EWS_26573619_Chip-Seq_HEK293_Human2.43922845
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39050318
22FUS_26573619_Chip-Seq_HEK293_Human2.38246070
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37320437
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.36232082
25AR_21909140_ChIP-Seq_LNCAP_Human2.36148789
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33302396
27GBX2_23144817_ChIP-Seq_PC3_Human2.31404561
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29563722
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.26735609
30TAF15_26573619_Chip-Seq_HEK293_Human2.24859382
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24187639
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22496847
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20600131
34VDR_22108803_ChIP-Seq_LS180_Human2.20319698
35ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19801426
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18388602
37E2F1_21310950_ChIP-Seq_MCF-7_Human2.17906850
38ETS1_20019798_ChIP-Seq_JURKAT_Human2.10021014
39VDR_23849224_ChIP-Seq_CD4+_Human2.08888079
40XRN2_22483619_ChIP-Seq_HELA_Human2.07378750
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06289918
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.99675152
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99451574
44P300_19829295_ChIP-Seq_ESCs_Human1.97843161
45ELK1_19687146_ChIP-ChIP_HELA_Human1.90609850
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87893938
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84818405
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84502121
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83848561
50FOXP3_21729870_ChIP-Seq_TREG_Human1.81666701
51* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77420014
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71982216
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70961184
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70066237
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69426799
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69015050
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.68003244
58DCP1A_22483619_ChIP-Seq_HELA_Human1.67992153
59TTF2_22483619_ChIP-Seq_HELA_Human1.65624546
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62844259
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60844873
62GABP_19822575_ChIP-Seq_HepG2_Human1.60608541
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59020190
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58528640
65CIITA_25753668_ChIP-Seq_RAJI_Human1.51244299
66MYC_22102868_ChIP-Seq_BL_Human1.51033134
67IRF1_19129219_ChIP-ChIP_H3396_Human1.49687727
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47020334
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45675279
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45482694
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44989151
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44304525
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43243496
74* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42915849
75* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42442425
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41194892
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40550204
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35407471
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.35095008
80KDM5A_27292631_Chip-Seq_BREAST_Human1.34269239
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34090726
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32835346
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32365216
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31861752
85CBP_20019798_ChIP-Seq_JUKART_Human1.30814362
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30814362
87* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30484976
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.28442281
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28128864
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27142890
91ER_23166858_ChIP-Seq_MCF-7_Human1.26531010
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25585193
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24491861
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22754599
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22745810
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22217378
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22130878
98SMAD4_21799915_ChIP-Seq_A2780_Human1.20994628
99* EZH2_27294783_Chip-Seq_NPCs_Mouse1.20779618
100RNF2_27304074_Chip-Seq_NSC_Mouse1.19961867
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19396636
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19013809
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19013809
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19013809
105* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18886031
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18306936
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18040863
108* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16363561
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15960789
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15097458
111TP53_22573176_ChIP-Seq_HFKS_Human1.13940084
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.13090791
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12908273
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11845499
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10828828
116CBX2_27304074_Chip-Seq_ESCs_Mouse1.10453680
117BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10129428
118* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09953371
119TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09762825
120SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08872575
121YY1_21170310_ChIP-Seq_MESCs_Mouse1.08554893
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08321855
123NOTCH1_21737748_ChIP-Seq_TLL_Human1.07987661
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06287135
125SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04873910
126* NFE2_27457419_Chip-Seq_LIVER_Mouse1.04821866
127* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03265624
128* NANOG_18555785_Chip-Seq_ESCs_Mouse1.03259698
129STAT3_23295773_ChIP-Seq_U87_Human1.03232068
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02615018
131SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01398561
132* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01242613
133* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01193654
134ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01042279
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00032467
136NANOG_19829295_ChIP-Seq_ESCs_Human0.99493834
137SOX2_19829295_ChIP-Seq_ESCs_Human0.99493834
138NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99310683
139* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97885416
140TFEB_21752829_ChIP-Seq_HELA_Human0.97562855
141MYC_18940864_ChIP-ChIP_HL60_Human0.97437381
142* RUNX2_22187159_ChIP-Seq_PCA_Human0.96523383
143FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96230673
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.95292404
145* NANOG_16153702_ChIP-ChIP_HESCs_Human0.94645574
146TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94050478
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92664306
148* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92346719
149TCF4_22108803_ChIP-Seq_LS180_Human0.92181593
150FLI1_21867929_ChIP-Seq_TH2_Mouse0.92015326
151* P53_22387025_ChIP-Seq_ESCs_Mouse0.91880230
152SRF_21415370_ChIP-Seq_HL-1_Mouse0.89954466
153TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89239204
154ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89231934
155ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88882901
156DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85802158
157SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85062247
158* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84712563
159PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83064565
160SOX2_16153702_ChIP-ChIP_HESCs_Human0.82448667

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.92145666
2MP0010094_abnormal_chromosome_stability3.88368444
3MP0003111_abnormal_nucleus_morphology3.43925462
4MP0004957_abnormal_blastocyst_morpholog3.36715392
5MP0003077_abnormal_cell_cycle3.35740332
6MP0008057_abnormal_DNA_replication3.27215579
7MP0008007_abnormal_cellular_replicative2.97071444
8MP0008058_abnormal_DNA_repair2.92733076
9MP0010030_abnormal_orbit_morphology2.88778521
10MP0003123_paternal_imprinting2.84843921
11MP0002638_abnormal_pupillary_reflex2.47340200
12MP0005394_taste/olfaction_phenotype2.44132823
13MP0005499_abnormal_olfactory_system2.44132823
14MP0003121_genomic_imprinting2.35417394
15MP0008932_abnormal_embryonic_tissue2.33297793
16MP0001529_abnormal_vocalization2.32270291
17MP0003880_abnormal_central_pattern2.22323244
18MP0009053_abnormal_anal_canal2.20016267
19MP0008877_abnormal_DNA_methylation2.07647102
20MP0000566_synostosis2.02846273
21MP0002396_abnormal_hematopoietic_system1.96732485
22MP0000350_abnormal_cell_proliferation1.91606863
23MP0001984_abnormal_olfaction1.90825063
24MP0010352_gastrointestinal_tract_polyps1.88743178
25* MP0001730_embryonic_growth_arrest1.87377087
26MP0006292_abnormal_olfactory_placode1.87342218
27MP0003890_abnormal_embryonic-extraembry1.76534020
28MP0004147_increased_porphyrin_level1.72601018
29MP0001697_abnormal_embryo_size1.60544674
30MP0001672_abnormal_embryogenesis/_devel1.60042190
31MP0005380_embryogenesis_phenotype1.60042190
32* MP0002085_abnormal_embryonic_tissue1.58682395
33MP0003937_abnormal_limbs/digits/tail_de1.55757118
34MP0000537_abnormal_urethra_morphology1.55276657
35MP0003941_abnormal_skin_development1.53984847
36* MP0002084_abnormal_developmental_patter1.53738754
37MP0009046_muscle_twitch1.53702857
38MP0002234_abnormal_pharynx_morphology1.53333470
39MP0002837_dystrophic_cardiac_calcinosis1.51150176
40MP0001293_anophthalmia1.51031919
41MP0004133_heterotaxia1.50604692
42MP0000631_abnormal_neuroendocrine_gland1.48130666
43MP0003315_abnormal_perineum_morphology1.47987817
44MP0003119_abnormal_digestive_system1.47265969
45MP0003786_premature_aging1.47171319
46MP0003984_embryonic_growth_retardation1.45105164
47MP0002088_abnormal_embryonic_growth/wei1.43919194
48MP0000778_abnormal_nervous_system1.43724054
49MP0004197_abnormal_fetal_growth/weight/1.43504777
50MP0003136_yellow_coat_color1.43028786
51MP0005076_abnormal_cell_differentiation1.42619373
52MP0001188_hyperpigmentation1.41838098
53MP0002736_abnormal_nociception_after1.41501557
54MP0006054_spinal_hemorrhage1.39105247
55MP0005253_abnormal_eye_physiology1.37976419
56MP0006276_abnormal_autonomic_nervous1.35936566
57MP0002938_white_spotting1.34897863
58MP0002102_abnormal_ear_morphology1.33204155
59MP0000049_abnormal_middle_ear1.31866116
60MP0002086_abnormal_extraembryonic_tissu1.31492756
61* MP0002080_prenatal_lethality1.27896658
62MP0000647_abnormal_sebaceous_gland1.26633243
63MP0003718_maternal_effect1.26545619
64MP0002210_abnormal_sex_determination1.25949080
65MP0003787_abnormal_imprinting1.25501347
66MP0003567_abnormal_fetal_cardiomyocyte1.25324744
67MP0004808_abnormal_hematopoietic_stem1.25159292
68MP0008789_abnormal_olfactory_epithelium1.24280167
69MP0005084_abnormal_gallbladder_morpholo1.21895355
70MP0002653_abnormal_ependyma_morphology1.21612797
71MP0010307_abnormal_tumor_latency1.21044882
72MP0000490_abnormal_crypts_of1.20116887
73MP0001286_abnormal_eye_development1.17809066
74MP0000428_abnormal_craniofacial_morphol1.17596577
75MP0006035_abnormal_mitochondrial_morpho1.15429935
76MP0008995_early_reproductive_senescence1.14177658
77MP0005551_abnormal_eye_electrophysiolog1.13951944
78MP0005257_abnormal_intraocular_pressure1.13149462
79MP0003755_abnormal_palate_morphology1.10338871
80MP0002249_abnormal_larynx_morphology1.10166426
81MP0003122_maternal_imprinting1.08363350
82MP0002090_abnormal_vision1.08278802
83MP0000313_abnormal_cell_death1.06335317
84MP0001119_abnormal_female_reproductive1.05481344
85MP0001145_abnormal_male_reproductive1.03082117
86MP0003763_abnormal_thymus_physiology1.03053002
87MP0002282_abnormal_trachea_morphology1.02975190
88MP0005248_abnormal_Harderian_gland1.01808899
89MP0002019_abnormal_tumor_incidence0.99935296
90MP0003938_abnormal_ear_development0.99552623
91MP0000372_irregular_coat_pigmentation0.99027462
92MP0003942_abnormal_urinary_system0.97569792
93MP0005391_vision/eye_phenotype0.96205346
94MP0000653_abnormal_sex_gland0.95642479
95MP0003935_abnormal_craniofacial_develop0.95523342
96MP0003385_abnormal_body_wall0.95442062
97MP0001485_abnormal_pinna_reflex0.95106012
98MP0003221_abnormal_cardiomyocyte_apopto0.94672661
99MP0009745_abnormal_behavioral_response0.94547228
100MP0001968_abnormal_touch/_nociception0.94519172
101MP0002111_abnormal_tail_morphology0.94164003
102MP0005645_abnormal_hypothalamus_physiol0.93046221
103MP0002822_catalepsy0.89500023
104MP0003283_abnormal_digestive_organ0.88773292
105MP0004885_abnormal_endolymph0.88769137
106MP0002752_abnormal_somatic_nervous0.88232718
107MP0002184_abnormal_innervation0.88113602
108MP0001929_abnormal_gametogenesis0.87880558
109MP0002932_abnormal_joint_morphology0.87447300
110MP0005195_abnormal_posterior_eye0.87342542
111MP0009672_abnormal_birth_weight0.87307949
112MP0009250_abnormal_appendicular_skeleto0.86647962
113MP0002092_abnormal_eye_morphology0.86400554
114MP0010368_abnormal_lymphatic_system0.86348569
115MP0002751_abnormal_autonomic_nervous0.85157647
116MP0003195_calcinosis0.85003092
117MP0009697_abnormal_copulation0.84886058
118MP0006072_abnormal_retinal_apoptosis0.83752963
119MP0001486_abnormal_startle_reflex0.83328465
120MP0002272_abnormal_nervous_system0.82392717
121MP0001915_intracranial_hemorrhage0.81801169
122MP0004215_abnormal_myocardial_fiber0.80526075
123MP0000703_abnormal_thymus_morphology0.80338698
124MP0004142_abnormal_muscle_tone0.80139034
125MP0003698_abnormal_male_reproductive0.80125776
126MP0005187_abnormal_penis_morphology0.80069950
127* MP0003861_abnormal_nervous_system0.80030736
128MP0000432_abnormal_head_morphology0.80002831
129MP0004811_abnormal_neuron_physiology0.79069977
130MP0003115_abnormal_respiratory_system0.78820118
131MP0001324_abnormal_eye_pigmentation0.78719654
132MP0005386_behavior/neurological_phenoty0.78606951
133MP0004924_abnormal_behavior0.78606951
134MP0002116_abnormal_craniofacial_bone0.78179742
135MP0000427_abnormal_hair_cycle0.77981104
136MP0002160_abnormal_reproductive_system0.77180852
137MP0000955_abnormal_spinal_cord0.76527472
138MP0005389_reproductive_system_phenotype0.76398935
139MP0000569_abnormal_digit_pigmentation0.75701056
140MP0009703_decreased_birth_body0.75480181
141MP0002233_abnormal_nose_morphology0.74195677
142MP0002177_abnormal_outer_ear0.72985983
143MP0002697_abnormal_eye_size0.72836655
144MP0001919_abnormal_reproductive_system0.71750639
145MP0002109_abnormal_limb_morphology0.68884131
146* MP0002114_abnormal_axial_skeleton0.66958645
147MP0000516_abnormal_urinary_system0.64608370
148MP0005367_renal/urinary_system_phenotyp0.64608370
149MP0002095_abnormal_skin_pigmentation0.64534824
150* MP0002398_abnormal_bone_marrow0.64505081

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.70155163
2Chromsome breakage (HP:0040012)3.61142158
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.35044181
4Colon cancer (HP:0003003)3.13973163
5Patellar aplasia (HP:0006443)3.13615229
6Aplasia/Hypoplasia of the fovea (HP:0008060)3.12373167
7Hypoplasia of the fovea (HP:0007750)3.12373167
8Medulloblastoma (HP:0002885)3.11603900
9Abnormality of the labia minora (HP:0012880)3.09403760
10Pancreatic cysts (HP:0001737)3.08276193
11True hermaphroditism (HP:0010459)2.98517321
12Volvulus (HP:0002580)2.95686219
13Abnormality of the fovea (HP:0000493)2.95411106
14Aplasia/Hypoplasia of the patella (HP:0006498)2.94165592
15Pancreatic fibrosis (HP:0100732)2.90168147
16Aplasia/Hypoplasia of the sternum (HP:0006714)2.82864080
17Medial flaring of the eyebrow (HP:0010747)2.81701495
18Meckel diverticulum (HP:0002245)2.75900272
19Abnormality of chromosome stability (HP:0003220)2.72567202
20Nephroblastoma (Wilms tumor) (HP:0002667)2.71369798
21Abnormality of the ileum (HP:0001549)2.71143801
22Abnormality of midbrain morphology (HP:0002418)2.67059064
23Molar tooth sign on MRI (HP:0002419)2.67059064
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.65488661
25Short 4th metacarpal (HP:0010044)2.65488661
26Ectopic kidney (HP:0000086)2.65413318
27Facial hemangioma (HP:0000329)2.60958471
28Gait imbalance (HP:0002141)2.59816744
29Embryonal renal neoplasm (HP:0011794)2.57659712
30Proximal placement of thumb (HP:0009623)2.56900244
31Increased nuchal translucency (HP:0010880)2.56536358
32Selective tooth agenesis (HP:0001592)2.55000550
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.54830149
34Breast hypoplasia (HP:0003187)2.54430906
35Methylmalonic acidemia (HP:0002912)2.54241787
36Congenital primary aphakia (HP:0007707)2.53015218
37Absent radius (HP:0003974)2.50377337
38Deviation of the thumb (HP:0009603)2.50002563
39Optic nerve hypoplasia (HP:0000609)2.45169237
40Abnormal lung lobation (HP:0002101)2.42121519
41Abnormality of the preputium (HP:0100587)2.41256307
42Aplasia involving forearm bones (HP:0009822)2.40848681
43Absent forearm bone (HP:0003953)2.40848681
44Abnormality of the anterior horn cell (HP:0006802)2.40380499
45Degeneration of anterior horn cells (HP:0002398)2.40380499
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.39420104
47Pendular nystagmus (HP:0012043)2.37917133
48Nephronophthisis (HP:0000090)2.37544053
49Cortical dysplasia (HP:0002539)2.37318587
50Nephrogenic diabetes insipidus (HP:0009806)2.36151159
51Small intestinal stenosis (HP:0012848)2.32095925
52Duodenal stenosis (HP:0100867)2.32095925
53Reticulocytopenia (HP:0001896)2.31352328
54Supernumerary spleens (HP:0009799)2.29262160
55Impulsivity (HP:0100710)2.29056101
56Ependymoma (HP:0002888)2.28099370
57Myelodysplasia (HP:0002863)2.26131415
58Genital tract atresia (HP:0001827)2.25343640
59Atresia of the external auditory canal (HP:0000413)2.25140626
60Oral leukoplakia (HP:0002745)2.25024966
61Agnosia (HP:0010524)2.24662450
62Progressive inability to walk (HP:0002505)2.23340248
63Aplastic anemia (HP:0001915)2.20106779
64Vaginal atresia (HP:0000148)2.19371572
65Atrophy/Degeneration involving motor neurons (HP:0007373)2.19205860
66Increased hepatocellular lipid droplets (HP:0006565)2.14491047
67Amyotrophic lateral sclerosis (HP:0007354)2.11903493
6811 pairs of ribs (HP:0000878)2.10717437
69Abnormal number of incisors (HP:0011064)2.10064677
70Lipid accumulation in hepatocytes (HP:0006561)2.08544147
71Inability to walk (HP:0002540)2.07899885
72Lissencephaly (HP:0001339)2.05015332
73Abnormality of the duodenum (HP:0002246)2.04455468
74Triphalangeal thumb (HP:0001199)2.03362854
75Acute necrotizing encephalopathy (HP:0006965)2.02100217
76Gastrointestinal atresia (HP:0002589)2.02090366
77Sclerocornea (HP:0000647)2.01057375
78Sloping forehead (HP:0000340)2.00870422
79Abnormality of alanine metabolism (HP:0010916)1.99837151
80Hyperalaninemia (HP:0003348)1.99837151
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99837151
82Papillary thyroid carcinoma (HP:0002895)1.99473406
83Increased CSF lactate (HP:0002490)1.99237054
84Anencephaly (HP:0002323)1.98536053
85Abnormality of the carotid arteries (HP:0005344)1.98172563
86Dandy-Walker malformation (HP:0001305)1.98069748
87Neoplasm of the pancreas (HP:0002894)1.96721367
88Postaxial hand polydactyly (HP:0001162)1.95562612
89Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.95330260
90Short 1st metacarpal (HP:0010034)1.95330260
91Shawl scrotum (HP:0000049)1.95229080
92Stenosis of the external auditory canal (HP:0000402)1.94758517
93Aplasia/Hypoplasia of the tongue (HP:0010295)1.94049363
94Methylmalonic aciduria (HP:0012120)1.93855575
95High anterior hairline (HP:0009890)1.93579682
96Intestinal atresia (HP:0011100)1.93455812
97Absent thumb (HP:0009777)1.92046671
98Hyperinsulinemic hypoglycemia (HP:0000825)1.91943718
99Capillary hemangiomas (HP:0005306)1.91849495
100Short thumb (HP:0009778)1.91365485
101Progressive macrocephaly (HP:0004481)1.90478827
102Tracheoesophageal fistula (HP:0002575)1.89223425
103Abnormality of the metopic suture (HP:0005556)1.89130460
104Preaxial hand polydactyly (HP:0001177)1.88161965
105Rhabdomyosarcoma (HP:0002859)1.87779717
106Optic nerve coloboma (HP:0000588)1.86999045
107Rough bone trabeculation (HP:0100670)1.86712572
108Hyperglycinemia (HP:0002154)1.86679843
109Type II lissencephaly (HP:0007260)1.86528437
110Oligodactyly (HP:0012165)1.86478218
111Poor coordination (HP:0002370)1.86089277
112Pancreatic islet-cell hyperplasia (HP:0004510)1.85821348
113Broad foot (HP:0001769)1.84937314
114Hepatoblastoma (HP:0002884)1.83607030
115Abnormality of the renal medulla (HP:0100957)1.81514805
116Acute encephalopathy (HP:0006846)1.80872435
117Postaxial foot polydactyly (HP:0001830)1.80684743
118Carpal bone hypoplasia (HP:0001498)1.80250003
119Gastrointestinal carcinoma (HP:0002672)1.80233232
120Malignant gastrointestinal tract tumors (HP:0006749)1.80233232
121Bone marrow hypocellularity (HP:0005528)1.79602194
122Bifid tongue (HP:0010297)1.79513688
123Neoplasm of the adrenal cortex (HP:0100641)1.79154579
124Mitochondrial inheritance (HP:0001427)1.79133656
125Abnormality of DNA repair (HP:0003254)1.78884449
126Abnormality of the phalanges of the hallux (HP:0010057)1.78704692
127Embryonal neoplasm (HP:0002898)1.78144367
128Hypothermia (HP:0002045)1.77217450
129Abnormality of the 4th metacarpal (HP:0010012)1.76269186
130Aplasia/Hypoplasia of the macula (HP:0008059)1.76203141
131Specific learning disability (HP:0001328)1.75664063
132Abnormality of the pons (HP:0007361)1.75606497
133Fibular aplasia (HP:0002990)1.75601182
1343-Methylglutaconic aciduria (HP:0003535)1.75377022
135Aqueductal stenosis (HP:0002410)1.74232785
136Limb dystonia (HP:0002451)1.73980046
137Short tibia (HP:0005736)1.73500592
138Acute myeloid leukemia (HP:0004808)1.73303370
139Abnormality of the proximal phalanges of the hand (HP:0009834)1.72642062
140Thyroid carcinoma (HP:0002890)1.72353992
141Septo-optic dysplasia (HP:0100842)1.72317192
142Neoplasm of the oral cavity (HP:0100649)1.72256479
143Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72248915
144Renal cortical cysts (HP:0000803)1.72206424
145Abolished electroretinogram (ERG) (HP:0000550)1.71948446
146Glioma (HP:0009733)1.71093934
147Hypoplasia of the pons (HP:0012110)1.70890848
148Shoulder girdle muscle weakness (HP:0003547)1.70022244
149Cutis marmorata (HP:0000965)1.69719875
150Narrow forehead (HP:0000341)1.69468562
151Retinal dysplasia (HP:0007973)1.69102431
152Pelvic girdle muscle weakness (HP:0003749)1.69046153
153Abnormality of the astrocytes (HP:0100707)1.68951240
154Astrocytoma (HP:0009592)1.68951240
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.68684244
156Abnormal glycosylation (HP:0012345)1.68364600
157Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.68364600
158Abnormal protein N-linked glycosylation (HP:0012347)1.68364600
159Abnormal protein glycosylation (HP:0012346)1.68364600
160Chronic hepatic failure (HP:0100626)1.67889805
161Premature graying of hair (HP:0002216)1.67808044
162Aplasia/hypoplasia of the humerus (HP:0006507)1.67753396
163Neoplasm of the adrenal gland (HP:0100631)1.67274119
164Synostosis of carpal bones (HP:0005048)1.65757680
165Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.64979786
166Horseshoe kidney (HP:0000085)1.64843171
167Abnormality of the intervertebral disk (HP:0005108)1.62480893
168Microglossia (HP:0000171)1.60904195
169Carpal synostosis (HP:0009702)1.60793136
170Amaurosis fugax (HP:0100576)1.60721850
171Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.60665153
172Abnormality of the incisor (HP:0000676)1.59615102
173Missing ribs (HP:0000921)1.59396320
174Abnormality of the 1st metacarpal (HP:0010009)1.55602597
175Diastasis recti (HP:0001540)1.54903906
176Renal duplication (HP:0000075)1.54567912

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.49507010
2CDC73.43602425
3TRIM283.38817810
4PASK3.26694304
5WEE13.26645747
6EIF2AK12.99559461
7SRPK12.90708956
8ACVR1B2.89571617
9FRK2.83818592
10WNK32.67348504
11MAP3K42.60347387
12NEK22.59911840
13MAP4K22.41164303
14MKNK12.40367950
15PLK42.38308294
16TGFBR12.19217994
17TTK2.09973091
18DYRK32.08866803
19TNIK2.03191417
20PLK32.03096850
21MKNK22.01388237
22BRSK21.97638605
23EIF2AK31.96328841
24TSSK61.92796474
25PLK11.92124050
26MAP2K71.88697209
27ATR1.69564125
28STK38L1.68697960
29CSNK1G21.67424018
30LATS11.63348833
31ERBB31.58712017
32CDK81.53399677
33CHEK21.49249014
34AURKB1.47087468
35RPS6KA41.46576038
36RPS6KB21.43933747
37CDK71.40071532
38CDK121.38282627
39CASK1.36164360
40CDK191.34358530
41VRK11.33124792
42TXK1.32672523
43VRK21.29204881
44ZAK1.28968389
45MARK11.27619138
46PLK21.25891705
47TAF11.24840040
48PINK11.24100732
49CHEK11.23335809
50STK31.22910116
51INSRR1.14296468
52TLK11.10259491
53NEK11.10182555
54MINK11.09346835
55DYRK21.08463450
56MST41.05931380
57ADRBK21.05195330
58ATM1.03529570
59STK161.01653716
60GRK10.99976788
61BCKDK0.99615898
62STK100.98818788
63PBK0.98349611
64MELK0.97993395
65TESK20.97666180
66CDK40.97128452
67AKT30.95644414
68EEF2K0.93155758
69FGFR30.92971756
70BRSK10.88039260
71OXSR10.87733707
72BRD40.87237381
73AURKA0.83878854
74LATS20.83862165
75PKN20.82408031
76CDK20.82036471
77SIK30.79337310
78FGFR10.79146084
79MAP3K80.78489536
80NUAK10.73609548
81FLT30.71438703
82PNCK0.71053294
83EIF2AK20.70085341
84PAK40.69939950
85CCNB10.69885647
86CDK60.69433289
87PRKCG0.67581775
88PIM10.67298165
89CDK10.66916810
90FGFR20.65793762
91LIMK10.64778978
92SCYL20.63210617
93MAP3K50.62755417
94STK40.62411557
95STK240.61517751
96BCR0.61307203
97BMPR1B0.60311250
98EPHA40.59113796
99NEK90.59026332
100JAK30.57903243
101STK390.57774854
102CDK90.56736487
103CHUK0.55253294
104PRKCE0.52272812
105CSNK2A10.52167201
106PTK2B0.51548581
107CSNK2A20.50526534
108YES10.48515567
109KSR10.48146225
110ALK0.47815597
111KIT0.47165885
112CSNK1G30.46480577
113MAP4K10.45559021
114PAK30.45417664
115GRK70.45345320
116RPS6KA50.44337230
117NLK0.44148566
118TESK10.42761798
119CDK30.42403095
120EPHA20.41301641
121PRKCI0.41227531
122CSNK1A1L0.40628774
123CSNK1G10.39941386
124CDK140.39618215
125PRKDC0.39180957
126CSNK1A10.38172531
127TIE10.37657003
128MAPKAPK30.35416174
129MAP2K40.34967676
130MAPK130.34887306
131ERBB40.34692248
132MAPKAPK50.34004444
133CSNK1D0.33752532
134DYRK1A0.33739007
135CLK10.32583358
136MAPK140.32471946
137FGFR40.31247650
138NTRK30.31112448
139MARK30.31013728
140CAMK2A0.30374426
141WNK40.30111132
142CDK180.28318379
143BRAF0.28062232
144CSNK1E0.26963268
145MTOR0.26771979
146NME10.26493696
147EGFR0.26056134
148ZAP700.25960282
149DAPK10.24517810

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.89269662
2Mismatch repair_Homo sapiens_hsa034303.55242660
3Spliceosome_Homo sapiens_hsa030403.36107025
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.33826385
5RNA transport_Homo sapiens_hsa030133.15079917
6Cell cycle_Homo sapiens_hsa041103.14124850
7RNA polymerase_Homo sapiens_hsa030202.81553255
8Homologous recombination_Homo sapiens_hsa034402.70238226
9Nucleotide excision repair_Homo sapiens_hsa034202.66259933
10Base excision repair_Homo sapiens_hsa034102.64978535
11Steroid biosynthesis_Homo sapiens_hsa001002.48829340
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.45842643
13Fanconi anemia pathway_Homo sapiens_hsa034602.40060035
14Basal transcription factors_Homo sapiens_hsa030222.37346522
15Non-homologous end-joining_Homo sapiens_hsa034502.28113376
16mRNA surveillance pathway_Homo sapiens_hsa030152.18278068
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15081815
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12938554
19RNA degradation_Homo sapiens_hsa030182.08418783
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02793681
21Maturity onset diabetes of the young_Homo sapiens_hsa049502.02679361
22Oxidative phosphorylation_Homo sapiens_hsa001902.01790568
23Propanoate metabolism_Homo sapiens_hsa006401.96767190
24Proteasome_Homo sapiens_hsa030501.96295737
25One carbon pool by folate_Homo sapiens_hsa006701.92178629
26Phototransduction_Homo sapiens_hsa047441.85843508
27p53 signaling pathway_Homo sapiens_hsa041151.85431824
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82013919
29Parkinsons disease_Homo sapiens_hsa050121.79236575
30Pyrimidine metabolism_Homo sapiens_hsa002401.79134947
31Nicotine addiction_Homo sapiens_hsa050331.74312969
32Butanoate metabolism_Homo sapiens_hsa006501.73077807
33Ribosome_Homo sapiens_hsa030101.65537530
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.62003973
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42217411
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36012997
37Epstein-Barr virus infection_Homo sapiens_hsa051691.31592368
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.29727018
39Herpes simplex infection_Homo sapiens_hsa051681.24277068
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24177316
41Antigen processing and presentation_Homo sapiens_hsa046121.23692345
42Huntingtons disease_Homo sapiens_hsa050161.22316688
43Basal cell carcinoma_Homo sapiens_hsa052171.20310336
44MicroRNAs in cancer_Homo sapiens_hsa052061.19479174
45Oocyte meiosis_Homo sapiens_hsa041141.19258558
46Fatty acid elongation_Homo sapiens_hsa000621.18689198
47Hippo signaling pathway_Homo sapiens_hsa043901.18206132
48TGF-beta signaling pathway_Homo sapiens_hsa043501.16954517
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16347676
50Colorectal cancer_Homo sapiens_hsa052101.16281088
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15712030
52Viral carcinogenesis_Homo sapiens_hsa052031.15671875
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13920202
54HTLV-I infection_Homo sapiens_hsa051661.10204393
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09994808
56Systemic lupus erythematosus_Homo sapiens_hsa053221.09991239
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03788567
58Taste transduction_Homo sapiens_hsa047421.03195340
59Purine metabolism_Homo sapiens_hsa002301.02332924
60Collecting duct acid secretion_Homo sapiens_hsa049660.97919897
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95764009
62Notch signaling pathway_Homo sapiens_hsa043300.93627302
63Small cell lung cancer_Homo sapiens_hsa052220.92139640
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90372106
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89799174
66Hedgehog signaling pathway_Homo sapiens_hsa043400.89659834
67Peroxisome_Homo sapiens_hsa041460.89523157
68Alzheimers disease_Homo sapiens_hsa050100.89111584
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88638041
70Thyroid cancer_Homo sapiens_hsa052160.87875735
71Primary immunodeficiency_Homo sapiens_hsa053400.84852258
72Protein export_Homo sapiens_hsa030600.84447584
73Legionellosis_Homo sapiens_hsa051340.84359121
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83352379
75GABAergic synapse_Homo sapiens_hsa047270.82549515
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82030429
77Measles_Homo sapiens_hsa051620.77754139
78Adherens junction_Homo sapiens_hsa045200.75443451
79Regulation of autophagy_Homo sapiens_hsa041400.74435343
80Hepatitis B_Homo sapiens_hsa051610.74085492
81Olfactory transduction_Homo sapiens_hsa047400.73603368
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71300114
83Viral myocarditis_Homo sapiens_hsa054160.70097406
84Pancreatic cancer_Homo sapiens_hsa052120.69967824
85Pyruvate metabolism_Homo sapiens_hsa006200.68305302
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.66339184
87Nitrogen metabolism_Homo sapiens_hsa009100.64634297
88Pathways in cancer_Homo sapiens_hsa052000.63646556
89Metabolic pathways_Homo sapiens_hsa011000.63118392
90Endometrial cancer_Homo sapiens_hsa052130.62985037
91Chronic myeloid leukemia_Homo sapiens_hsa052200.61937163
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60380945
93Prostate cancer_Homo sapiens_hsa052150.60002682
94Morphine addiction_Homo sapiens_hsa050320.57900137
95Selenocompound metabolism_Homo sapiens_hsa004500.57007052
96Ether lipid metabolism_Homo sapiens_hsa005650.55945794
97Wnt signaling pathway_Homo sapiens_hsa043100.55052228
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54748311
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54623752
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54296028
101Alcoholism_Homo sapiens_hsa050340.53243506
102Sulfur metabolism_Homo sapiens_hsa009200.52079616
103Cardiac muscle contraction_Homo sapiens_hsa042600.51742922
104Influenza A_Homo sapiens_hsa051640.50917124
105Apoptosis_Homo sapiens_hsa042100.50644753
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48670858
107Dopaminergic synapse_Homo sapiens_hsa047280.47679666
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46585140
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45926682
110Shigellosis_Homo sapiens_hsa051310.45249349
111Tryptophan metabolism_Homo sapiens_hsa003800.45180303
112N-Glycan biosynthesis_Homo sapiens_hsa005100.44790900
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.44538666
114FoxO signaling pathway_Homo sapiens_hsa040680.44533749
115Caffeine metabolism_Homo sapiens_hsa002320.43494440
116Vitamin B6 metabolism_Homo sapiens_hsa007500.43159783
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42374076
118T cell receptor signaling pathway_Homo sapiens_hsa046600.40756543
119Folate biosynthesis_Homo sapiens_hsa007900.40343743
120mTOR signaling pathway_Homo sapiens_hsa041500.40197777
121Asthma_Homo sapiens_hsa053100.39675275
122Serotonergic synapse_Homo sapiens_hsa047260.39227909
123Allograft rejection_Homo sapiens_hsa053300.38961419
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38547391
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.37919191
126Circadian entrainment_Homo sapiens_hsa047130.37866340
127Leishmaniasis_Homo sapiens_hsa051400.37795481
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37290734
129Fatty acid metabolism_Homo sapiens_hsa012120.37223606
130Melanoma_Homo sapiens_hsa052180.36252898
131Toxoplasmosis_Homo sapiens_hsa051450.36143895
132Acute myeloid leukemia_Homo sapiens_hsa052210.36040869
133Proteoglycans in cancer_Homo sapiens_hsa052050.34224295
134Hematopoietic cell lineage_Homo sapiens_hsa046400.34155804
135Non-small cell lung cancer_Homo sapiens_hsa052230.34037221
136Bladder cancer_Homo sapiens_hsa052190.33784645
137beta-Alanine metabolism_Homo sapiens_hsa004100.33613509
138Glutathione metabolism_Homo sapiens_hsa004800.32961823
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32874507
140Circadian rhythm_Homo sapiens_hsa047100.32678217
141Axon guidance_Homo sapiens_hsa043600.31389575
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31260470
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.30773523
144Primary bile acid biosynthesis_Homo sapiens_hsa001200.30149892
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30021173
146alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28476195
147Prolactin signaling pathway_Homo sapiens_hsa049170.28137363
148Glutamatergic synapse_Homo sapiens_hsa047240.28046430
149Autoimmune thyroid disease_Homo sapiens_hsa053200.27995779
150Renal cell carcinoma_Homo sapiens_hsa052110.27493612
151Tight junction_Homo sapiens_hsa045300.26818175
152Carbon metabolism_Homo sapiens_hsa012000.26643400
153Biosynthesis of amino acids_Homo sapiens_hsa012300.26577139
154AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25518437
155Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25512600
156RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23310173
157Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23019007
158Amphetamine addiction_Homo sapiens_hsa050310.22211748
159Leukocyte transendothelial migration_Homo sapiens_hsa046700.22043599
160Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21321811
161Type I diabetes mellitus_Homo sapiens_hsa049400.21276970
162Linoleic acid metabolism_Homo sapiens_hsa005910.20757150
163Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19025019

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