RNF20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.21481910
2regulation of DNA methylation (GO:0044030)5.17179596
3mitotic metaphase plate congression (GO:0007080)4.74956010
4metaphase plate congression (GO:0051310)4.74516382
5establishment of chromosome localization (GO:0051303)4.70425310
6establishment of integrated proviral latency (GO:0075713)4.31933669
7protein localization to kinetochore (GO:0034501)4.22335284
8regulation of sister chromatid cohesion (GO:0007063)4.08481575
9pre-miRNA processing (GO:0031054)4.03851041
10histone H3-K4 trimethylation (GO:0080182)4.02298910
11regulation of RNA export from nucleus (GO:0046831)4.00600207
12spindle assembly involved in mitosis (GO:0090307)3.87848767
13regulation of centriole replication (GO:0046599)3.83940969
14nuclear pore complex assembly (GO:0051292)3.67146811
15histone H3-K36 demethylation (GO:0070544)3.61855762
16regulation of nucleobase-containing compound transport (GO:0032239)3.58425764
17monoubiquitinated protein deubiquitination (GO:0035520)3.57135236
18mitotic spindle organization (GO:0007052)3.55034198
19protein localization to chromosome, centromeric region (GO:0071459)3.47027087
20mitotic sister chromatid cohesion (GO:0007064)3.45072730
21paraxial mesoderm development (GO:0048339)3.37492699
22mRNA splice site selection (GO:0006376)3.31692876
23double-strand break repair via nonhomologous end joining (GO:0006303)3.18017677
24non-recombinational repair (GO:0000726)3.18017677
25peptidyl-lysine trimethylation (GO:0018023)3.17209400
26NLS-bearing protein import into nucleus (GO:0006607)3.14451109
27pore complex assembly (GO:0046931)3.12880656
28establishment of viral latency (GO:0019043)3.09776748
29mRNA stabilization (GO:0048255)3.09359333
30RNA stabilization (GO:0043489)3.09359333
31kinetochore organization (GO:0051383)3.03625453
32chromatin remodeling at centromere (GO:0031055)3.03085462
33negative regulation of DNA recombination (GO:0045910)3.02738527
34DNA topological change (GO:0006265)3.00506631
35ribosome assembly (GO:0042255)3.00503314
36DNA replication-independent nucleosome organization (GO:0034724)2.99993748
37DNA replication-independent nucleosome assembly (GO:0006336)2.99993748
38regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.99750015
39histone H3-K9 methylation (GO:0051567)2.97758650
40CENP-A containing nucleosome assembly (GO:0034080)2.96446838
41spindle checkpoint (GO:0031577)2.95492624
42DNA ligation (GO:0006266)2.94957182
43cytoplasmic mRNA processing body assembly (GO:0033962)2.92961552
44regulation of mitotic metaphase/anaphase transition (GO:0030071)2.90589025
45regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90589025
46mitotic sister chromatid segregation (GO:0000070)2.90264569
47nuclear pore organization (GO:0006999)2.90251153
48stress granule assembly (GO:0034063)2.89974593
49mitotic nuclear envelope disassembly (GO:0007077)2.88703984
50centrosome localization (GO:0051642)2.86662416
51IMP metabolic process (GO:0046040)2.86221831
52ATP-dependent chromatin remodeling (GO:0043044)2.84593789
53IMP biosynthetic process (GO:0006188)2.84067189
54glial cell proliferation (GO:0014009)2.82785999
55meiotic cell cycle (GO:0051321)2.81295721
56positive regulation of mitotic sister chromatid separation (GO:1901970)2.78824162
57positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.78824162
58regulation of mitotic sister chromatid separation (GO:0010965)2.78068367
59regulation of mitotic sister chromatid segregation (GO:0033047)2.78068367
60regulation of sister chromatid segregation (GO:0033045)2.78068367
61histone H3-K4 methylation (GO:0051568)2.77784486
62histone demethylation (GO:0016577)2.76989018
63membrane disassembly (GO:0030397)2.76373934
64nuclear envelope disassembly (GO:0051081)2.76373934
65histone lysine demethylation (GO:0070076)2.75621165
66chromosome condensation (GO:0030261)2.75497027
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.74876605
68peptidyl-lysine methylation (GO:0018022)2.74216547
69nucleus organization (GO:0006997)2.74144123
70poly(A)+ mRNA export from nucleus (GO:0016973)2.73237042
71DNA damage response, detection of DNA damage (GO:0042769)2.72777368
72mitotic spindle checkpoint (GO:0071174)2.72710795
73negative regulation of mitotic sister chromatid separation (GO:2000816)2.71778975
74negative regulation of sister chromatid segregation (GO:0033046)2.71778975
75negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.71778975
76negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.71778975
77negative regulation of mitotic sister chromatid segregation (GO:0033048)2.71778975
78regulation of translational fidelity (GO:0006450)2.71649585
79histone H3-K9 demethylation (GO:0033169)2.68975359
80protein-DNA complex disassembly (GO:0032986)2.68646754
81nucleosome disassembly (GO:0006337)2.68646754
82negative regulation of chromosome segregation (GO:0051985)2.67826013
83DNA unwinding involved in DNA replication (GO:0006268)2.63896353
84telomere maintenance via telomerase (GO:0007004)2.63702912
85axon ensheathment in central nervous system (GO:0032291)2.62393278
86central nervous system myelination (GO:0022010)2.62393278
87DNA strand elongation involved in DNA replication (GO:0006271)2.60905418
88chromatin assembly (GO:0031497)2.59730486
89regulation of mRNA splicing, via spliceosome (GO:0048024)2.58820038
90regulation of centrosome cycle (GO:0046605)2.58474624
91protein localization to chromosome (GO:0034502)2.57614419
92regulation of mRNA stability (GO:0043488)2.57601420
93positive regulation of cell cycle checkpoint (GO:1901978)2.56888361
94regulation of RNA stability (GO:0043487)2.56441117
95regulation of growth hormone secretion (GO:0060123)2.56420634
96protein demethylation (GO:0006482)2.55001588
97protein dealkylation (GO:0008214)2.55001588
98megakaryocyte development (GO:0035855)2.54997155
99negative regulation of DNA repair (GO:0045738)2.54764130
100histone H3-K9 modification (GO:0061647)2.53389737
101regulation of transcription from RNA polymerase I promoter (GO:0006356)2.53281844
102cell proliferation in forebrain (GO:0021846)2.53029234
103mitotic G2/M transition checkpoint (GO:0044818)2.52627205
104positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.52426202
105intra-S DNA damage checkpoint (GO:0031573)2.51992451
106type B pancreatic cell development (GO:0003323)2.51453254
107spindle organization (GO:0007051)2.50791721
108DNA strand elongation (GO:0022616)2.49972827
109negative regulation of DNA-dependent DNA replication (GO:2000104)2.49747652
110RNA-dependent DNA replication (GO:0006278)2.49463897
111nerve growth factor signaling pathway (GO:0038180)2.49167737
112hyperosmotic salinity response (GO:0042538)2.49092829
113regulation of mitotic spindle organization (GO:0060236)2.48211057
114histone lysine methylation (GO:0034968)2.47208545
115cerebral cortex radially oriented cell migration (GO:0021799)2.45130079
116regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.43892355
117regulation of establishment of cell polarity (GO:2000114)2.41846560
118mitotic chromosome condensation (GO:0007076)2.41484613
119regulation of meiosis I (GO:0060631)2.39721717
120regulation of histone H3-K27 methylation (GO:0061085)2.36520906
121establishment of mitotic spindle orientation (GO:0000132)2.36441548
122regulation of RNA splicing (GO:0043484)2.33031564
123negative regulation of histone methylation (GO:0031061)2.30827363
124regulation of mRNA processing (GO:0050684)2.30580767
125negative regulation of oligodendrocyte differentiation (GO:0048715)2.29849662
126asymmetric protein localization (GO:0008105)2.28240703
127sister chromatid cohesion (GO:0007062)2.26130931
128protein K11-linked deubiquitination (GO:0035871)2.25549549
129* regulation of histone methylation (GO:0031060)2.22398086
130positive thymic T cell selection (GO:0045059)2.22121524
131regulation of exit from mitosis (GO:0007096)2.21113615
132establishment of spindle orientation (GO:0051294)2.19878942
133regulation of mRNA metabolic process (GO:1903311)2.19806511
134photoreceptor cell differentiation (GO:0046530)2.19479276
135eye photoreceptor cell differentiation (GO:0001754)2.19479276
136microtubule anchoring (GO:0034453)2.17494845
137nonmotile primary cilium assembly (GO:0035058)2.16436757
138establishment of mitotic spindle localization (GO:0040001)2.16132977
139chromatin assembly or disassembly (GO:0006333)2.15987408
140microtubule depolymerization (GO:0007019)2.15914470
141positive regulation of histone H3-K4 methylation (GO:0051571)2.13822090
142regulation of spindle organization (GO:0090224)2.11245506
143sister chromatid segregation (GO:0000819)2.11159940
144positive regulation of RNA splicing (GO:0033120)2.10134638
145alternative mRNA splicing, via spliceosome (GO:0000380)2.09932034
146regulation of histone H3-K4 methylation (GO:0051569)2.09792847
147definitive hemopoiesis (GO:0060216)2.08865898
148embryonic retina morphogenesis in camera-type eye (GO:0060059)2.08730098
149establishment of spindle localization (GO:0051293)2.07370055
150regulation of DNA endoreduplication (GO:0032875)2.05252309
151resolution of meiotic recombination intermediates (GO:0000712)2.04419624
152regulation of establishment or maintenance of cell polarity (GO:0032878)2.04182292
153axon ensheathment (GO:0008366)2.03861481
154ensheathment of neurons (GO:0007272)2.03861481
155myelination (GO:0042552)2.03661249
156positive regulation of chromosome segregation (GO:0051984)2.03315960
157peptidyl-tyrosine autophosphorylation (GO:0038083)2.02324418
158microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.02251132
159microtubule polymerization or depolymerization (GO:0031109)2.02072808
160mesodermal cell differentiation (GO:0048333)2.01929084
161positive T cell selection (GO:0043368)2.01377547
162positive regulation of gamma-delta T cell activation (GO:0046645)2.00793743
163centriole replication (GO:0007099)2.00707462
164pyrimidine dimer repair (GO:0006290)2.00703192
165V(D)J recombination (GO:0033151)1.99536044
166negative regulation of mRNA splicing, via spliceosome (GO:0048025)1.99079641
167regulation of histone H3-K9 methylation (GO:0051570)1.98942300
168oligodendrocyte differentiation (GO:0048709)1.98236925
169insulin-like growth factor receptor signaling pathway (GO:0048009)1.98023225
170positive regulation of mRNA processing (GO:0050685)1.96226441
171regulation of chromosome segregation (GO:0051983)1.95823337
172neural tube formation (GO:0001841)1.95490914
173negative regulation of neurotransmitter secretion (GO:0046929)1.95450000
174positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)1.94754462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.88787367
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.89980096
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.42457575
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.29660294
5AR_21909140_ChIP-Seq_LNCAP_Human3.25326155
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.86172205
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.57188936
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.56368667
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.37098034
10HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.36833775
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.36310045
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35265827
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.31349454
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24822394
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21004341
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19605173
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.18901293
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18230507
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10723099
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.00612469
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99436736
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99151531
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98370632
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95319336
25* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94680361
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.90649020
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89687271
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.88180481
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.85173614
30TP53_16413492_ChIP-PET_HCT116_Human1.83111425
31EWS_26573619_Chip-Seq_HEK293_Human1.83069044
32GBX2_23144817_ChIP-Seq_PC3_Human1.81352751
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.80632268
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77483947
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74990699
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74392617
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71892244
38* ELK1_19687146_ChIP-ChIP_HELA_Human1.71547590
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63762599
40* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.60962347
41* GABP_17652178_ChIP-ChIP_JURKAT_Human1.58215062
42FUS_26573619_Chip-Seq_HEK293_Human1.57882333
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52933738
44PKCTHETA_26484144_Chip-Seq_BREAST_Human1.52126150
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52098199
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45186185
47DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45009384
48FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.44308321
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.43685243
50RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.42521120
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42510386
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.42423607
53STAT3_23295773_ChIP-Seq_U87_Human1.41467250
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41322304
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39622776
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38926091
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37934291
58* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35615773
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34680713
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34680713
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33513509
62SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.33175671
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33157923
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31014891
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30989479
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30365474
67EZH2_22144423_ChIP-Seq_EOC_Human1.26816774
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23601350
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23258524
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22797034
71TCF4_23295773_ChIP-Seq_U87_Human1.22305863
72SOX17_20123909_ChIP-Seq_XEN_Mouse1.22181869
73* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21766962
74RUNX_20019798_ChIP-Seq_JUKART_Human1.21703367
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.21677380
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.21556609
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19239323
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.19199259
79AHR_22903824_ChIP-Seq_MCF-7_Human1.15800800
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15300523
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14747350
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13089081
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12453241
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12396654
85EP300_21415370_ChIP-Seq_HL-1_Mouse1.11713623
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.11522985
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.11384743
88P300_19829295_ChIP-Seq_ESCs_Human1.10780307
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10591969
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10035452
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09756873
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09686503
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09420321
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09272197
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08597363
96MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08045185
97TAF15_26573619_Chip-Seq_HEK293_Human1.07531452
98GATA1_22025678_ChIP-Seq_K562_Human1.07389361
99CLOCK_20551151_ChIP-Seq_293T_Human1.06928980
100* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05016333
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.04735395
102CHD1_26751641_Chip-Seq_LNCaP_Human1.04508275
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04151383
104TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04106468
105TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03377042
106LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03327234
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03074542
108CIITA_25753668_ChIP-Seq_RAJI_Human1.02844062
109ISL1_27105846_Chip-Seq_CPCs_Mouse1.02646407
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02602394
111JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01918625
112CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01603964
113RNF2_27304074_Chip-Seq_ESCs_Mouse1.01601379
114CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01311968
115SCL_19346495_ChIP-Seq_HPC-7_Human1.00696681
116SMAD4_21799915_ChIP-Seq_A2780_Human1.00059102
117NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99632680
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99066326
119PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98666236
120NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98460426
121ER_23166858_ChIP-Seq_MCF-7_Human0.98438434
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98248188
123POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98075803
124KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96803895
125DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95711621
126TCF4_18268006_ChIP-ChIP_LS174T_Human0.95528421
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94749073
128EGR1_19374776_ChIP-ChIP_THP-1_Human0.94621037
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94250908
130AR_21572438_ChIP-Seq_LNCaP_Human0.94201378
131ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94163163
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93782413
133STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93698421
134CBX2_27304074_Chip-Seq_ESCs_Mouse0.93679640
135SOX2_21211035_ChIP-Seq_LN229_Gbm0.93366592
136TBL1_22424771_ChIP-Seq_293T_Human0.93280029
137EZH2_27304074_Chip-Seq_ESCs_Mouse0.93205016
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92613319
139SOX9_26525672_Chip-Seq_HEART_Mouse0.92365446
140SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92331651
141E2F1_21310950_ChIP-Seq_MCF-7_Human0.91180611
142SOX2_16153702_ChIP-ChIP_HESCs_Human0.91172257
143AR_19668381_ChIP-Seq_PC3_Human0.91020803
144ETS1_20019798_ChIP-Seq_JURKAT_Human0.90754053
145NANOG_21062744_ChIP-ChIP_HESCs_Human0.89348080
146EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89132852
147KDM2B_26808549_Chip-Seq_JURKAT_Human0.89114360
148NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89060583
149* GABP_19822575_ChIP-Seq_HepG2_Human0.89028841
150TTF2_22483619_ChIP-Seq_HELA_Human0.88765490
151FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88393632
152HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87751412
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87667215
154CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86451778
155KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86369615
156SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86222647
157PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85365757
158SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85177152
159P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83635139
160CMYC_18555785_Chip-Seq_ESCs_Mouse0.83492344
161WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83321488
162CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82619845
163LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81974186
164POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81598567

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.54731323
2MP0003121_genomic_imprinting3.50526954
3MP0000569_abnormal_digit_pigmentation3.24216564
4MP0004957_abnormal_blastocyst_morpholog2.50078795
5MP0003718_maternal_effect2.42227254
6MP0008877_abnormal_DNA_methylation2.36480360
7MP0003941_abnormal_skin_development2.05038635
8MP0003111_abnormal_nucleus_morphology1.98922259
9MP0000537_abnormal_urethra_morphology1.95206658
10MP0010030_abnormal_orbit_morphology1.94528316
11MP0003937_abnormal_limbs/digits/tail_de1.94146147
12MP0008932_abnormal_embryonic_tissue1.91805689
13MP0001984_abnormal_olfaction1.84930797
14MP0003122_maternal_imprinting1.84620322
15MP0003123_paternal_imprinting1.79234392
16MP0009780_abnormal_chondrocyte_physiolo1.73371729
17MP0008057_abnormal_DNA_replication1.73029713
18MP0001299_abnormal_eye_distance/1.71307924
19MP0002396_abnormal_hematopoietic_system1.69572303
20MP0000778_abnormal_nervous_system1.62327804
21MP0003045_fibrosis1.61975044
22MP0002102_abnormal_ear_morphology1.60606862
23MP0003077_abnormal_cell_cycle1.59625778
24MP0000566_synostosis1.53875015
25MP0004859_abnormal_synaptic_plasticity1.53692594
26MP0008961_abnormal_basal_metabolism1.48069571
27MP0003693_abnormal_embryo_hatching1.47998093
28MP0010352_gastrointestinal_tract_polyps1.45936585
29MP0000920_abnormal_myelination1.40509093
30MP0000733_abnormal_muscle_development1.39288111
31MP0003950_abnormal_plasma_membrane1.38615655
32MP0004808_abnormal_hematopoietic_stem1.37185436
33MP0005076_abnormal_cell_differentiation1.33775507
34MP0002269_muscular_atrophy1.33329430
35MP0010094_abnormal_chromosome_stability1.32203400
36MP0001697_abnormal_embryo_size1.31960709
37MP0000428_abnormal_craniofacial_morphol1.31507293
38MP0000579_abnormal_nail_morphology1.30384673
39MP0004885_abnormal_endolymph1.28250494
40MP0003935_abnormal_craniofacial_develop1.27520817
41MP0004742_abnormal_vestibular_system1.27124291
42MP0001485_abnormal_pinna_reflex1.26366182
43MP0002080_prenatal_lethality1.25847306
44MP0000631_abnormal_neuroendocrine_gland1.25025818
45MP0001849_ear_inflammation1.22361383
46MP0005409_darkened_coat_color1.21949796
47MP0003890_abnormal_embryonic-extraembry1.21377912
48MP0004233_abnormal_muscle_weight1.21211623
49MP0003755_abnormal_palate_morphology1.19008114
50MP0006054_spinal_hemorrhage1.17409732
51MP0003632_abnormal_nervous_system1.16949598
52MP0000751_myopathy1.14454478
53MP0009703_decreased_birth_body1.13182739
54MP0008789_abnormal_olfactory_epithelium1.09586108
55MP0004270_analgesia1.09411246
56MP0003303_peritoneal_inflammation1.09350692
57MP0003861_abnormal_nervous_system1.07927816
58MP0000955_abnormal_spinal_cord1.07841688
59MP0005257_abnormal_intraocular_pressure1.06612379
60MP0000432_abnormal_head_morphology1.06606900
61MP0004811_abnormal_neuron_physiology1.06321032
62MP0003300_gastrointestinal_ulcer1.05630950
63MP0001346_abnormal_lacrimal_gland1.04435508
64MP0002751_abnormal_autonomic_nervous1.02347823
65MP0005646_abnormal_pituitary_gland1.01814195
66MP0010307_abnormal_tumor_latency1.01500406
67MP0005395_other_phenotype1.01064956
68MP0000465_gastrointestinal_hemorrhage1.01063216
69MP0005248_abnormal_Harderian_gland1.00881830
70MP0006292_abnormal_olfactory_placode1.00077100
71MP0005310_abnormal_salivary_gland0.99503801
72MP0003567_abnormal_fetal_cardiomyocyte0.99462266
73MP0002084_abnormal_developmental_patter0.99089465
74MP0001730_embryonic_growth_arrest0.97349404
75MP0006072_abnormal_retinal_apoptosis0.97288364
76MP0002116_abnormal_craniofacial_bone0.97056177
77MP0005171_absent_coat_pigmentation0.96658746
78MP0010678_abnormal_skin_adnexa0.94805570
79MP0003763_abnormal_thymus_physiology0.93358409
80MP0001851_eye_inflammation0.91938434
81MP0010234_abnormal_vibrissa_follicle0.90737370
82MP0002233_abnormal_nose_morphology0.90599636
83MP0000762_abnormal_tongue_morphology0.90377413
84MP0000703_abnormal_thymus_morphology0.90256105
85MP0002938_white_spotting0.90076013
86MP0002085_abnormal_embryonic_tissue0.89308214
87MP0005408_hypopigmentation0.89137984
88MP0002177_abnormal_outer_ear0.88719941
89MP0002925_abnormal_cardiovascular_devel0.88066213
90MP0005394_taste/olfaction_phenotype0.86954775
91MP0005499_abnormal_olfactory_system0.86954775
92MP0001486_abnormal_startle_reflex0.86825958
93MP0005380_embryogenesis_phenotype0.86521698
94MP0001672_abnormal_embryogenesis/_devel0.86521698
95MP0005384_cellular_phenotype0.86457974
96MP0003385_abnormal_body_wall0.85939000
97MP0003221_abnormal_cardiomyocyte_apopto0.83828658
98MP0008058_abnormal_DNA_repair0.83394971
99MP0001929_abnormal_gametogenesis0.80534468
100MP0002697_abnormal_eye_size0.80493939
101MP0001177_atelectasis0.80279559
102MP0001915_intracranial_hemorrhage0.80163141
103MP0008007_abnormal_cellular_replicative0.80045001
104MP0003705_abnormal_hypodermis_morpholog0.79924992
105MP0002092_abnormal_eye_morphology0.79865364
106MP0004087_abnormal_muscle_fiber0.79716156
107MP0000358_abnormal_cell_content/0.79603762
108MP0001293_anophthalmia0.79382367
109MP0002111_abnormal_tail_morphology0.79231146
110MP0000377_abnormal_hair_follicle0.79101253
111MP0002109_abnormal_limb_morphology0.78962582
112MP0003938_abnormal_ear_development0.78075344
113MP0005391_vision/eye_phenotype0.77473711
114MP0003984_embryonic_growth_retardation0.76999860
115MP0004185_abnormal_adipocyte_glucose0.76930022
116MP0002081_perinatal_lethality0.76868851
117MP0002152_abnormal_brain_morphology0.76799670
118MP0009250_abnormal_appendicular_skeleto0.76395299
119MP0002877_abnormal_melanocyte_morpholog0.76320512
120MP0003136_yellow_coat_color0.76313797
121MP0002088_abnormal_embryonic_growth/wei0.75550468
122MP0001958_emphysema0.75441720
123MP0003943_abnormal_hepatobiliary_system0.75375395
124MP0000350_abnormal_cell_proliferation0.74665712
125MP0004197_abnormal_fetal_growth/weight/0.73969563
126MP0005075_abnormal_melanosome_morpholog0.73386698
127MP0003699_abnormal_female_reproductive0.73011054
128MP0002398_abnormal_bone_marrow0.72965109
129MP0002114_abnormal_axial_skeleton0.72636520
130MP0003115_abnormal_respiratory_system0.72475540
131MP0000313_abnormal_cell_death0.71240852
132MP0009672_abnormal_birth_weight0.71120092
133MP0001286_abnormal_eye_development0.70916660
134MP0001340_abnormal_eyelid_morphology0.70882017
135MP0002089_abnormal_postnatal_growth/wei0.70035062
136MP0005621_abnormal_cell_physiology0.69387992
137MP0000049_abnormal_middle_ear0.69266346
138MP0000747_muscle_weakness0.69077014
139MP0002086_abnormal_extraembryonic_tissu0.68768874
140MP0003183_abnormal_peptide_metabolism0.68494771
141MP0002210_abnormal_sex_determination0.66579376
142MP0000749_muscle_degeneration0.66509074

Predicted human phenotypes

RankGene SetZ-score
1Syringomyelia (HP:0003396)5.00791846
2Spinal cord lesions (HP:0100561)5.00791846
3Volvulus (HP:0002580)3.76934786
4Abnormality of the fingertips (HP:0001211)3.50039132
5Papillary thyroid carcinoma (HP:0002895)3.31889139
6Cortical dysplasia (HP:0002539)3.09951491
7Degeneration of the lateral corticospinal tracts (HP:0002314)3.05298412
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.05298412
9Chromsome breakage (HP:0040012)2.95758888
10Rhabdomyosarcoma (HP:0002859)2.86775320
11Truncal obesity (HP:0001956)2.67825184
12Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59752847
13Multiple enchondromatosis (HP:0005701)2.50790289
14Facial hemangioma (HP:0000329)2.49013985
15Proximal placement of thumb (HP:0009623)2.44807155
16Aplasia/Hypoplasia of the sternum (HP:0006714)2.42194135
17Supernumerary spleens (HP:0009799)2.40841640
18Abnormality of chromosome stability (HP:0003220)2.35189272
19Termporal pattern (HP:0011008)2.32406777
20Insidious onset (HP:0003587)2.32406777
21Macroorchidism (HP:0000053)2.32397051
22Thick eyebrow (HP:0000574)2.27041865
23Short 4th metacarpal (HP:0010044)2.26576253
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.26576253
25Oligodactyly (hands) (HP:0001180)2.24408056
26Thyroid carcinoma (HP:0002890)2.22582671
27Abnormality of the intervertebral disk (HP:0005108)2.21986812
28Abnormality of the corticospinal tract (HP:0002492)2.21405137
29Abnormality of the hip-girdle musculature (HP:0001445)2.21063231
30Abnormality of the musculature of the pelvis (HP:0001469)2.21063231
31Deviation of the thumb (HP:0009603)2.18874615
32Long eyelashes (HP:0000527)2.18015285
33Neoplasm of striated muscle (HP:0009728)2.14781021
34Increased nuchal translucency (HP:0010880)2.12828122
35Absent frontal sinuses (HP:0002688)2.12665809
36Difficulty running (HP:0009046)2.11411464
37Aqueductal stenosis (HP:0002410)2.10507481
38Gonadotropin excess (HP:0000837)2.10346583
39Microvesicular hepatic steatosis (HP:0001414)2.08605125
40Vertebral arch anomaly (HP:0008438)2.07953622
41Pelvic girdle muscle weakness (HP:0003749)2.03709033
42Broad distal phalanx of finger (HP:0009836)2.00231761
43Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.98882384
44Abdominal situs inversus (HP:0003363)1.96609254
45Abnormality of abdominal situs (HP:0011620)1.96609254
46Medulloblastoma (HP:0002885)1.92365537
47Inappropriate behavior (HP:0000719)1.92128560
48Arnold-Chiari malformation (HP:0002308)1.91690781
49Large earlobe (HP:0009748)1.91113431
50Meckel diverticulum (HP:0002245)1.91088236
51Subacute progressive viral hepatitis (HP:0006572)1.89752340
52Broad thumb (HP:0011304)1.89114299
53Oligodactyly (HP:0012165)1.88854306
54Prominent nose (HP:0000448)1.88697717
55Neoplasm of the oral cavity (HP:0100649)1.88445811
56Limited elbow extension (HP:0001377)1.87791793
57Small epiphyses (HP:0010585)1.87550215
58Abnormal lung lobation (HP:0002101)1.86190926
59Narrow palate (HP:0000189)1.84652091
60Broad alveolar ridges (HP:0000187)1.84550765
61Colon cancer (HP:0003003)1.83191557
62Microtia (HP:0008551)1.83069681
63Septo-optic dysplasia (HP:0100842)1.82508590
64Urethral obstruction (HP:0000796)1.82291768
65Malignant gastrointestinal tract tumors (HP:0006749)1.82116478
66Gastrointestinal carcinoma (HP:0002672)1.82116478
67Impulsivity (HP:0100710)1.81116623
68Spastic diplegia (HP:0001264)1.80736295
69Biliary tract neoplasm (HP:0100574)1.80404924
70Bowel diverticulosis (HP:0005222)1.78678662
71Spastic gait (HP:0002064)1.78172148
72Increased serum pyruvate (HP:0003542)1.78012298
73Peripheral hypomyelination (HP:0007182)1.77952013
74Tubulointerstitial nephritis (HP:0001970)1.76815309
75Overriding aorta (HP:0002623)1.75938754
76Germ cell neoplasia (HP:0100728)1.75702185
77Agnosia (HP:0010524)1.75656544
78Obsessive-compulsive behavior (HP:0000722)1.75434454
79Trigonocephaly (HP:0000243)1.74927623
80Deep philtrum (HP:0002002)1.74102698
81High anterior hairline (HP:0009890)1.73958325
82Transitional cell carcinoma of the bladder (HP:0006740)1.73914824
83Cystic hygroma (HP:0000476)1.72468502
84Apathy (HP:0000741)1.72111206
85Radioulnar synostosis (HP:0002974)1.71357792
86Genetic anticipation (HP:0003743)1.71000749
87Abnormality of the metopic suture (HP:0005556)1.70543806
88Bifid tongue (HP:0010297)1.70206010
89Anteriorly placed anus (HP:0001545)1.69633711
90Hypopigmentation of the fundus (HP:0007894)1.68782847
91Choanal atresia (HP:0000453)1.68462622
92Abnormality of the parathyroid morphology (HP:0011766)1.68226625
93Abnormality of the labia minora (HP:0012880)1.67891849
94Abnormality of the ileum (HP:0001549)1.67511340
95Dysmetric saccades (HP:0000641)1.67268368
96Abnormality of the labia (HP:0000058)1.67160058
97Abnormal auditory evoked potentials (HP:0006958)1.66412500
98Shoulder girdle muscle weakness (HP:0003547)1.65868033
99Nephroblastoma (Wilms tumor) (HP:0002667)1.65458578
100Hammertoe (HP:0001765)1.64074783
101Ectopic kidney (HP:0000086)1.63827409
102Low anterior hairline (HP:0000294)1.63119406
103Striae distensae (HP:0001065)1.62904801
104Microglossia (HP:0000171)1.62157031
105Insomnia (HP:0100785)1.61345266
106Hypoplastic female external genitalia (HP:0012815)1.61212812
107Abnormality of glycolysis (HP:0004366)1.60749861
108Broad phalanges of the hand (HP:0009768)1.60543002
109Cafe-au-lait spot (HP:0000957)1.60170407
110Asymmetry of the thorax (HP:0001555)1.60040850
111Leiomyosarcoma (HP:0100243)1.59270869
112Uterine leiomyosarcoma (HP:0002891)1.59270869
113Micropenis (HP:0000054)1.58926752
114Patellar aplasia (HP:0006443)1.58815776
115Embryonal renal neoplasm (HP:0011794)1.58731209
116Labial hypoplasia (HP:0000066)1.58318737
117Ependymoma (HP:0002888)1.57660574
118Synophrys (HP:0000664)1.57631735
119Abnormality of the antihelix (HP:0009738)1.57582302
120Enlarged penis (HP:0000040)1.57381719
121Abnormality of the lower motor neuron (HP:0002366)1.57078041
122Poor coordination (HP:0002370)1.56844887
123Abnormality of the preputium (HP:0100587)1.56647467
124Heterotopia (HP:0002282)1.56531682
125Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.56388380
126Resting tremor (HP:0002322)1.56334520
127Breast carcinoma (HP:0003002)1.55715537
128Ankle contracture (HP:0006466)1.55709656
129Gait imbalance (HP:0002141)1.55450945
130Hyperacusis (HP:0010780)1.55278614
131Diminished motivation (HP:0000745)1.54738479
132Broad phalanx (HP:0006009)1.54622276
133Intestinal malrotation (HP:0002566)1.54541634
134Astrocytoma (HP:0009592)1.54386219
135Abnormality of the astrocytes (HP:0100707)1.54386219
136Bladder carcinoma (HP:0002862)1.53506500
137Bladder neoplasm (HP:0009725)1.53506500
138Abnormality of the parietal bone (HP:0002696)1.53318239
139Limb-girdle muscle atrophy (HP:0003797)1.53154983
140Widely spaced teeth (HP:0000687)1.52718216
141Neoplasm of the thyroid gland (HP:0100031)1.52629129
142Shallow orbits (HP:0000586)1.51767306
143Tapered finger (HP:0001182)1.51755470
144Cupped ear (HP:0000378)1.51357384
145Sandal gap (HP:0001852)1.50346661
146Urinary urgency (HP:0000012)1.49743919
147Elfin facies (HP:0004428)1.48764922
148Disinhibition (HP:0000734)1.48672755
149Downturned corners of mouth (HP:0002714)1.48314755
150Gastroesophageal reflux (HP:0002020)1.47936260
151Broad finger (HP:0001500)1.47685643
152Flat cornea (HP:0007720)1.47342190
153Abnormality of chromosome segregation (HP:0002916)1.47244012
154Supernumerary ribs (HP:0005815)1.47031456
155Spina bifida occulta (HP:0003298)1.46615365
156Highly arched eyebrow (HP:0002553)1.46345905
157Abnormal hair whorl (HP:0010721)1.45723348
158Hypoplastic ischia (HP:0003175)1.44656278
159Hypoplastic labia majora (HP:0000059)1.44227011
160Deeply set eye (HP:0000490)1.43466238
161Aplasia/Hypoplasia of the patella (HP:0006498)1.41737454
162Broad long bones (HP:0005622)1.41615227
163Abnormality of the 4th metacarpal (HP:0010012)1.41519831
164Disproportionate tall stature (HP:0001519)1.39784914
165Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.39341806
166Skull defect (HP:0001362)1.38459497
167Supernumerary bones of the axial skeleton (HP:0009144)1.37194104
168Thyroiditis (HP:0100646)1.37098142
169Protruding tongue (HP:0010808)1.36919835

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.09677571
2CDK123.37694992
3TTK3.31427846
4BRD43.21887355
5LATS12.76244041
6NEK12.70528340
7CDC72.46972047
8MKNK22.41024660
9PNCK2.33782036
10CSNK1A1L2.10115198
11CASK2.05522649
12INSRR2.04989170
13STK31.84343905
14NTRK21.82158441
15MKNK11.74531758
16TNIK1.73812404
17FGFR21.71909914
18BUB11.71657293
19NEK61.67943741
20TAF11.67446603
21SRPK11.66376746
22TXK1.64394433
23NEK21.63902169
24STK241.63816692
25PBK1.57913038
26FRK1.57404574
27NTRK11.53189092
28MAP3K41.52074144
29EEF2K1.51988998
30PRPF4B1.51859317
31NUAK11.50545410
32ACVR1B1.47798338
33EIF2AK11.46581992
34PLK11.42893218
35WNK11.37911256
36EPHA31.28554004
37PDGFRB1.28536840
38NEK91.28358245
39MAP3K91.27096146
40PKN11.26191247
41DMPK1.26165803
42LATS21.20552998
43STK391.18130586
44MAPK131.16502654
45CDK91.13513889
46CSNK1G11.12459220
47TRPM71.11341678
48EIF2AK31.10600795
49CSNK1E1.09873200
50PDGFRA1.08721927
51CAMK1G1.07759567
52DYRK31.05936614
53TRIM281.04925946
54MAP3K61.04190615
55SCYL21.04181424
56CHEK11.03496545
57CLK11.03362793
58MELK1.02791646
59CSNK1G21.02364819
60CSNK1G31.02165632
61KSR11.00475006
62MAP3K100.99636621
63STK100.99614425
64ALK0.98047345
65MAP4K20.93911132
66FGFR30.91438173
67EPHB10.87211282
68* ATM0.85956949
69FGR0.82719598
70MARK20.82303026
71CAMK1D0.82215871
72CDK10.81855297
73BRSK20.81766545
74ERBB30.80765658
75TAOK30.80124874
76MOS0.79723324
77MST40.78801753
78FGFR10.77547932
79PASK0.77384534
80BCR0.77183228
81MTOR0.76746347
82STK38L0.76550284
83RPS6KA50.75426456
84CHEK20.73603289
85SGK4940.73365797
86SGK2230.73365797
87PRKACB0.73117091
88SGK30.73051309
89ITK0.72861039
90WEE10.71985675
91PRKCH0.71721788
92PLK20.71221994
93CHUK0.70673694
94PLK30.70321283
95MAPK100.69847192
96CDK20.68696006
97YES10.66677278
98PRKCQ0.66603889
99PTK60.66107895
100ATR0.64527511
101MARK30.64463479
102CDK60.62205898
103UHMK10.62051060
104GSK3B0.62043248
105DDR20.61785653
106AURKA0.61692186
107MINK10.60777211
108SIK20.60748911
109BMPR1B0.60163320
110PLK40.60019538
111TYRO30.59664534
112MAP2K70.59660603
113CSNK1D0.59322313
114NTRK30.58904813
115PRKD10.58734701
116MAPK140.58443136
117HIPK20.57916222
118MARK10.57309459
119MAP3K20.56694894
120STK110.56667197
121CDK30.56334440
122MET0.55457044
123MAPK80.55040722
124ICK0.55003700
125PTK20.54038591
126BRSK10.53980300
127PRKDC0.53954877
128ERBB40.53142751
129AURKB0.53052370
130OXSR10.53022168
131RPS6KB10.52849535
132DYRK20.52721554
133EIF2AK20.52626087
134STK40.52150284
135DYRK1A0.52082801
136CSNK2A20.51524544
137SGK10.51333031
138CDK70.50789402
139RET0.50322167
140ROCK20.49415459
141PAK60.48856179
142AKT20.47343696
143RAF10.45981152
144CDK180.45954959
145DYRK1B0.45593902
146CDK150.44226317
147STK160.43442061
148RPS6KA40.43347025
149CDK140.42368954
150CDK11A0.42318051
151MAP3K80.39832432
152LRRK20.39776186

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.14961767
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.03200557
3DNA replication_Homo sapiens_hsa030302.54664864
4Base excision repair_Homo sapiens_hsa034102.08729720
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.08163583
6Thyroid cancer_Homo sapiens_hsa052161.84060190
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70048433
8Nucleotide excision repair_Homo sapiens_hsa034201.70026015
9Vitamin B6 metabolism_Homo sapiens_hsa007501.59523065
10mRNA surveillance pathway_Homo sapiens_hsa030151.49604462
11MicroRNAs in cancer_Homo sapiens_hsa052061.46710144
12Non-homologous end-joining_Homo sapiens_hsa034501.43970072
13Cell cycle_Homo sapiens_hsa041101.42914299
14Colorectal cancer_Homo sapiens_hsa052101.41771016
15Biosynthesis of amino acids_Homo sapiens_hsa012301.38158847
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.34894524
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.30692660
18Basal transcription factors_Homo sapiens_hsa030221.29134941
19Axon guidance_Homo sapiens_hsa043601.28445761
20Propanoate metabolism_Homo sapiens_hsa006401.28235914
21Renal cell carcinoma_Homo sapiens_hsa052111.26511366
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22280271
23Carbon metabolism_Homo sapiens_hsa012001.20815526
24T cell receptor signaling pathway_Homo sapiens_hsa046601.19223461
25Pancreatic cancer_Homo sapiens_hsa052121.15830932
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13012553
27Dorso-ventral axis formation_Homo sapiens_hsa043201.10001868
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09368294
29Primary immunodeficiency_Homo sapiens_hsa053401.09251879
30Homologous recombination_Homo sapiens_hsa034401.08397486
31Type II diabetes mellitus_Homo sapiens_hsa049301.07622943
32ErbB signaling pathway_Homo sapiens_hsa040121.07308792
33Prostate cancer_Homo sapiens_hsa052151.06369585
34Chronic myeloid leukemia_Homo sapiens_hsa052201.03948639
35Focal adhesion_Homo sapiens_hsa045101.00276862
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00233743
37mTOR signaling pathway_Homo sapiens_hsa041501.00147866
38One carbon pool by folate_Homo sapiens_hsa006700.99366366
39Endometrial cancer_Homo sapiens_hsa052130.98863983
40Spliceosome_Homo sapiens_hsa030400.98680032
41B cell receptor signaling pathway_Homo sapiens_hsa046620.97922794
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97787824
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97705025
44Adherens junction_Homo sapiens_hsa045200.96665902
45Proteasome_Homo sapiens_hsa030500.96174615
46Wnt signaling pathway_Homo sapiens_hsa043100.96157390
47Glutamatergic synapse_Homo sapiens_hsa047240.96085560
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94420055
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93653121
50Lysine degradation_Homo sapiens_hsa003100.92053370
51Protein export_Homo sapiens_hsa030600.91395829
52Choline metabolism in cancer_Homo sapiens_hsa052310.89787104
53Hematopoietic cell lineage_Homo sapiens_hsa046400.89695101
54MAPK signaling pathway_Homo sapiens_hsa040100.89511549
55Glioma_Homo sapiens_hsa052140.89075143
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88386847
57Small cell lung cancer_Homo sapiens_hsa052220.87883083
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87791145
59FoxO signaling pathway_Homo sapiens_hsa040680.87718150
60Non-small cell lung cancer_Homo sapiens_hsa052230.87482860
61RNA degradation_Homo sapiens_hsa030180.86158835
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85992607
63Pyruvate metabolism_Homo sapiens_hsa006200.85769605
64Proteoglycans in cancer_Homo sapiens_hsa052050.85309058
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.85130099
66Chemokine signaling pathway_Homo sapiens_hsa040620.84983944
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84966564
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84957800
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.84659253
70GnRH signaling pathway_Homo sapiens_hsa049120.84606387
71TGF-beta signaling pathway_Homo sapiens_hsa043500.84145715
72Pentose phosphate pathway_Homo sapiens_hsa000300.83712245
73ECM-receptor interaction_Homo sapiens_hsa045120.83351204
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.82988387
75Viral myocarditis_Homo sapiens_hsa054160.82821245
76Prolactin signaling pathway_Homo sapiens_hsa049170.82798942
77Fanconi anemia pathway_Homo sapiens_hsa034600.82727736
78Alcoholism_Homo sapiens_hsa050340.82604342
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82561419
80Viral carcinogenesis_Homo sapiens_hsa052030.82457387
81Notch signaling pathway_Homo sapiens_hsa043300.81485105
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81342047
83Ether lipid metabolism_Homo sapiens_hsa005650.81298277
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.81225936
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80234871
86Platelet activation_Homo sapiens_hsa046110.80065181
87Long-term potentiation_Homo sapiens_hsa047200.79478553
88Ras signaling pathway_Homo sapiens_hsa040140.79450165
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78683179
90Insulin secretion_Homo sapiens_hsa049110.78488056
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.78072407
92Long-term depression_Homo sapiens_hsa047300.78065437
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77718969
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77279018
95Basal cell carcinoma_Homo sapiens_hsa052170.76984521
96Circadian entrainment_Homo sapiens_hsa047130.76940383
97Oocyte meiosis_Homo sapiens_hsa041140.76917177
98Pathways in cancer_Homo sapiens_hsa052000.75482693
99Hippo signaling pathway_Homo sapiens_hsa043900.74712730
100HTLV-I infection_Homo sapiens_hsa051660.73904560
101RNA polymerase_Homo sapiens_hsa030200.73235324
102RNA transport_Homo sapiens_hsa030130.72866504
103Serotonergic synapse_Homo sapiens_hsa047260.72610524
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70794320
105Tight junction_Homo sapiens_hsa045300.70734253
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70637016
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70320698
108Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69443184
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69346097
110Ovarian steroidogenesis_Homo sapiens_hsa049130.69027202
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68381709
112Morphine addiction_Homo sapiens_hsa050320.68357408
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68352076
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68215797
115cAMP signaling pathway_Homo sapiens_hsa040240.68072660
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.67143236
117Cocaine addiction_Homo sapiens_hsa050300.66594369
118Circadian rhythm_Homo sapiens_hsa047100.65464883
119Gap junction_Homo sapiens_hsa045400.65257551
120Rap1 signaling pathway_Homo sapiens_hsa040150.65085688
121Hedgehog signaling pathway_Homo sapiens_hsa043400.64950825
122Inositol phosphate metabolism_Homo sapiens_hsa005620.64629293
123Hepatitis B_Homo sapiens_hsa051610.64459610
124Steroid biosynthesis_Homo sapiens_hsa001000.64421422
125Cholinergic synapse_Homo sapiens_hsa047250.64275038
126Endocytosis_Homo sapiens_hsa041440.64252838
127Dilated cardiomyopathy_Homo sapiens_hsa054140.64060884
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63971181
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63807671
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63531154
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63439852
132p53 signaling pathway_Homo sapiens_hsa041150.63352842
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63300022
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59676819
135Purine metabolism_Homo sapiens_hsa002300.59321516
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58914462
137Selenocompound metabolism_Homo sapiens_hsa004500.54639002
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50321456
139Melanogenesis_Homo sapiens_hsa049160.47565936
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40601202
141Insulin signaling pathway_Homo sapiens_hsa049100.40267650
142beta-Alanine metabolism_Homo sapiens_hsa004100.38680459
143Nicotine addiction_Homo sapiens_hsa050330.38648430
144Estrogen signaling pathway_Homo sapiens_hsa049150.37038140
145Pyrimidine metabolism_Homo sapiens_hsa002400.35184378

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