RNF207

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.20970791
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.04991762
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.94237753
4ATP synthesis coupled proton transport (GO:0015986)5.94237753
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.24268492
6respiratory electron transport chain (GO:0022904)5.16657397
7sarcomere organization (GO:0045214)5.04481462
8electron transport chain (GO:0022900)5.02042160
9regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.79185360
10cardiac myofibril assembly (GO:0055003)4.78725989
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.60649859
12cellular ketone body metabolic process (GO:0046950)4.57308872
13negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.52316693
14myofibril assembly (GO:0030239)4.43797207
15regulation of rhodopsin mediated signaling pathway (GO:0022400)4.36891357
16negative regulation of protein localization to cell surface (GO:2000009)4.34357488
17rhodopsin mediated signaling pathway (GO:0016056)4.29427816
18positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.28267596
19adult heart development (GO:0007512)4.21200199
20negative regulation of potassium ion transmembrane transport (GO:1901380)4.12927516
21regulation of actin filament-based movement (GO:1903115)4.07831805
22ventricular cardiac muscle cell action potential (GO:0086005)4.05347672
23ketone body metabolic process (GO:1902224)4.05077005
24regulation of relaxation of muscle (GO:1901077)4.02987095
25DNA deamination (GO:0045006)3.96760502
26ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.92248886
27regulation of sarcomere organization (GO:0060297)3.90249964
28cytidine metabolic process (GO:0046087)3.89849426
29cytidine catabolic process (GO:0006216)3.89849426
30cytidine deamination (GO:0009972)3.89849426
31regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.88532422
32cardiac muscle contraction (GO:0060048)3.87884400
33behavioral response to nicotine (GO:0035095)3.87492041
34regulation of cell communication by electrical coupling (GO:0010649)3.82944808
35kynurenine metabolic process (GO:0070189)3.80057537
36cardiac muscle tissue morphogenesis (GO:0055008)3.77963994
37detection of calcium ion (GO:0005513)3.74014086
38regulation of membrane repolarization (GO:0060306)3.73193763
39pyrimidine ribonucleoside catabolic process (GO:0046133)3.61269964
40regulation of cardioblast differentiation (GO:0051890)3.60844421
41regulation of striated muscle contraction (GO:0006942)3.57411398
42regulation of ATP catabolic process (GO:1903289)3.55262804
43regulation of ATPase activity (GO:0043462)3.55262804
44positive regulation of action potential (GO:0045760)3.53915396
45cardiac muscle cell development (GO:0055013)3.53462040
46muscle filament sliding (GO:0030049)3.52797588
47actin-myosin filament sliding (GO:0033275)3.52797588
48cardiac muscle tissue development (GO:0048738)3.51199530
49regulation of cardiac muscle contraction (GO:0055117)3.50584341
50regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.50396354
51indolalkylamine catabolic process (GO:0046218)3.44690589
52tryptophan catabolic process (GO:0006569)3.44690589
53indole-containing compound catabolic process (GO:0042436)3.44690589
54nephron tubule morphogenesis (GO:0072078)3.44370650
55nephron epithelium morphogenesis (GO:0072088)3.44370650
56sarcoplasmic reticulum calcium ion transport (GO:0070296)3.38468947
57bundle of His cell to Purkinje myocyte communication (GO:0086069)3.37694859
58response to epinephrine (GO:0071871)3.37232832
59muscle tissue morphogenesis (GO:0060415)3.35441036
60cardiac cell development (GO:0055006)3.31914150
61fatty acid transmembrane transport (GO:1902001)3.31850985
62cardiac right ventricle morphogenesis (GO:0003215)3.30699245
63endoderm formation (GO:0001706)3.30139843
64ATP biosynthetic process (GO:0006754)3.25821063
65photoreceptor cell maintenance (GO:0045494)3.24257852
66positive regulation of potassium ion transmembrane transport (GO:1901381)3.24089110
67axon ensheathment in central nervous system (GO:0032291)3.22536598
68central nervous system myelination (GO:0022010)3.22536598
69response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.22349438
70cell communication involved in cardiac conduction (GO:0086065)3.21929028
71regulation of heart rate (GO:0002027)3.21807105
72regulation of voltage-gated calcium channel activity (GO:1901385)3.20917850
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20078455
74neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.19895759
75cellular response to epinephrine stimulus (GO:0071872)3.19414686
76regulation of the force of heart contraction (GO:0002026)3.18947114
77regulation of cardiac muscle cell contraction (GO:0086004)3.18599739
78neuron cell-cell adhesion (GO:0007158)3.16229610
79positive regulation of ATP catabolic process (GO:1903291)3.14899164
80positive regulation of ATPase activity (GO:0032781)3.14899164
81cardiac ventricle formation (GO:0003211)3.14464939
82regulation of skeletal muscle contraction (GO:0014819)3.09437853
83actin-mediated cell contraction (GO:0070252)3.08579166
84negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.08140645
85negative regulation of calcium ion transmembrane transport (GO:1903170)3.08140645
86inner mitochondrial membrane organization (GO:0007007)3.07818171
87water-soluble vitamin biosynthetic process (GO:0042364)3.07201564
88striated muscle contraction (GO:0006941)3.06827354
89cardiac muscle hypertrophy (GO:0003300)3.06404144
90heart process (GO:0003015)3.04971858
91heart contraction (GO:0060047)3.04971858
92cardiac muscle cell action potential (GO:0086001)3.03318276
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03241951
94cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02854867
95negative regulation of cytosolic calcium ion concentration (GO:0051481)3.02055127
96atrial septum morphogenesis (GO:0060413)3.00764311
97cardiac chamber formation (GO:0003207)3.00192973
98potassium ion export (GO:0071435)2.99266904
99hydrogen ion transmembrane transport (GO:1902600)2.98395838
100response to caffeine (GO:0031000)2.97947918
101calcium-mediated signaling using intracellular calcium source (GO:0035584)2.96856314
102heart trabecula formation (GO:0060347)2.95538124
103actomyosin structure organization (GO:0031032)2.95500609
104regulation of heart rate by cardiac conduction (GO:0086091)2.95391185
105photoreceptor cell differentiation (GO:0046530)2.95261779
106eye photoreceptor cell differentiation (GO:0001754)2.95261779
107negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.94896432
108purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.94328529
109long-chain fatty acid biosynthetic process (GO:0042759)2.94001349
110auditory receptor cell stereocilium organization (GO:0060088)2.92956636
111relaxation of cardiac muscle (GO:0055119)2.91453978
112cardiac conduction (GO:0061337)2.90525310
113positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.89050445
114cardiac muscle cell action potential involved in contraction (GO:0086002)2.88572040
115striated muscle hypertrophy (GO:0014897)2.88137959
116regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.87504769
117fucose catabolic process (GO:0019317)2.87198899
118L-fucose metabolic process (GO:0042354)2.87198899
119L-fucose catabolic process (GO:0042355)2.87198899
120establishment of protein localization to mitochondrial membrane (GO:0090151)2.85813184
121regulation of heart contraction (GO:0008016)2.82877064
122purine nucleoside triphosphate biosynthetic process (GO:0009145)2.82432480
123detection of light stimulus involved in sensory perception (GO:0050962)2.82151067
124detection of light stimulus involved in visual perception (GO:0050908)2.82151067
125regulation of action potential (GO:0098900)2.81869125
126regulation of calcium ion transmembrane transport (GO:1903169)2.80441557
127regulation of calcium ion transmembrane transporter activity (GO:1901019)2.80441557
128sulfate transmembrane transport (GO:1902358)2.79279306
129regulation of catecholamine metabolic process (GO:0042069)2.79265078
130regulation of dopamine metabolic process (GO:0042053)2.79265078
131short-term memory (GO:0007614)2.78457717
132positive regulation of heart rate (GO:0010460)2.77579730
133muscle hypertrophy (GO:0014896)2.77554331
134indolalkylamine metabolic process (GO:0006586)2.73999262
135renal tubule morphogenesis (GO:0061333)2.72370242
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70284724
137photoreceptor cell development (GO:0042461)2.69643430
138carnitine shuttle (GO:0006853)2.68569487
139positive regulation of fatty acid oxidation (GO:0046321)2.65799710
140cardiac septum development (GO:0003279)2.65094535
141positive regulation of sodium ion transport (GO:0010765)2.65080110
142membrane depolarization during action potential (GO:0086010)2.63662149
143adrenergic receptor signaling pathway (GO:0071875)2.61919363
144tryptophan metabolic process (GO:0006568)2.60779943
145cell communication by electrical coupling (GO:0010644)2.59384000
146regulation of memory T cell differentiation (GO:0043380)2.58272403
147negative regulation of heart rate (GO:0010459)2.57021407
148respiratory chain complex IV assembly (GO:0008535)2.56926420
149action potential (GO:0001508)2.55602778
150positive regulation of defense response to virus by host (GO:0002230)2.53124883
151response to pheromone (GO:0019236)2.52966962
152neuronal action potential (GO:0019228)2.52817682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.77931048
2GBX2_23144817_ChIP-Seq_PC3_Human3.25419947
3ZNF274_21170338_ChIP-Seq_K562_Hela3.08875619
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.84943534
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.64821881
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57548148
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53707702
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52074555
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41304672
10VDR_22108803_ChIP-Seq_LS180_Human2.38880902
11TAF15_26573619_Chip-Seq_HEK293_Human2.37604476
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29731878
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18963100
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16601265
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12643548
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.12165464
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11855543
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10763000
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10763000
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10446868
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08509990
22EP300_21415370_ChIP-Seq_HL-1_Mouse2.07116829
23CBX2_27304074_Chip-Seq_ESCs_Mouse2.00716986
24* EZH2_27294783_Chip-Seq_ESCs_Mouse1.93151714
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84660149
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82199384
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82059253
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82007497
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78472830
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77400135
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73910412
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65105241
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65079594
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63038780
35P300_19829295_ChIP-Seq_ESCs_Human1.61521877
36* RNF2_27304074_Chip-Seq_ESCs_Mouse1.61287325
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56050981
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54232978
39ER_23166858_ChIP-Seq_MCF-7_Human1.53822091
40SMAD4_21799915_ChIP-Seq_A2780_Human1.52749614
41ERA_21632823_ChIP-Seq_H3396_Human1.50408774
42DROSHA_22980978_ChIP-Seq_HELA_Human1.49360525
43BCAT_22108803_ChIP-Seq_LS180_Human1.48755269
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48715872
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47614345
46AR_21572438_ChIP-Seq_LNCaP_Human1.46546572
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45848614
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.44923151
49REST_21632747_ChIP-Seq_MESCs_Mouse1.43918941
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43763115
51OCT4_20526341_ChIP-Seq_ESCs_Human1.41919330
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41131221
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40616171
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.40232114
55FUS_26573619_Chip-Seq_HEK293_Human1.40148321
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37484532
57NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36623680
58MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.35360164
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33080042
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.32675508
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.31353461
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.31238690
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31140512
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.28295467
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26283654
66MYC_19829295_ChIP-Seq_ESCs_Human1.25025735
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25003174
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.24560278
69TP53_22573176_ChIP-Seq_HFKS_Human1.24354506
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24165804
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24030412
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21735260
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21581476
74P53_21459846_ChIP-Seq_SAOS-2_Human1.21306157
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21270266
76RNF2_27304074_Chip-Seq_NSC_Mouse1.19673640
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18145520
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.17857607
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.16731731
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16507171
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.15779760
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15502803
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.15502803
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15337887
85HOXB7_26014856_ChIP-Seq_BT474_Human1.15298357
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14819541
87IRF1_19129219_ChIP-ChIP_H3396_Human1.14526211
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14357104
89ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14300971
90TAF2_19829295_ChIP-Seq_ESCs_Human1.13903371
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13430123
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12708605
93REST_18959480_ChIP-ChIP_MESCs_Mouse1.12198728
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12070241
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11496247
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.11395465
97* CTCF_27219007_Chip-Seq_Bcells_Human1.10549000
98NCOR_22424771_ChIP-Seq_293T_Human1.10377546
99P53_22387025_ChIP-Seq_ESCs_Mouse1.10127547
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09874330
101SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09748833
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.09588393
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09281089
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09275397
105EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08717959
106* PHF8_20622853_ChIP-Seq_HELA_Human1.08597539
107EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08518167
108NANOG_20526341_ChIP-Seq_ESCs_Human1.08298385
109AR_20517297_ChIP-Seq_VCAP_Human1.06979695
110AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06786935
111P300_18555785_Chip-Seq_ESCs_Mouse1.06095938
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.06045953
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.05964224
114TAL1_26923725_Chip-Seq_HPCs_Mouse1.05905541
115SOX2_18555785_Chip-Seq_ESCs_Mouse1.05425550
116IGF1R_20145208_ChIP-Seq_DFB_Human1.05319410
117EWS_26573619_Chip-Seq_HEK293_Human1.05296786
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04351622
119TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03753615
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.03649968
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02977292
122RUNX2_22187159_ChIP-Seq_PCA_Human1.02953016
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02723335
124NANOG_19829295_ChIP-Seq_ESCs_Human1.02460130
125SOX2_19829295_ChIP-Seq_ESCs_Human1.02460130
126TCF4_22108803_ChIP-Seq_LS180_Human1.02445589
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02372690
128TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01734640
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01692992
130RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00721111
131FOXH1_21741376_ChIP-Seq_ESCs_Human1.00590997
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99901123
133TCF4_23295773_ChIP-Seq_U87_Human0.98979998
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98708040
135CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98479996
136EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98232332
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97924490
138MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97169209
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.97060916
140* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96847757
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96587639
142RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96191397
143NMYC_18555785_Chip-Seq_ESCs_Mouse0.96145059
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.95147457
145MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94448302
146KDM2B_26808549_Chip-Seq_REH_Human0.94265015
147ZFX_18555785_Chip-Seq_ESCs_Mouse0.93684231
148* NFYB_21822215_ChIP-Seq_K562_Human0.92887311
149* TBL1_22424771_ChIP-Seq_293T_Human0.92872825
150STAT3_23295773_ChIP-Seq_U87_Human0.92741955
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.91996565
152AR_25329375_ChIP-Seq_VCAP_Human0.91972505
153EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91675391
154GATA4_25053715_ChIP-Seq_YYC3_Human0.91673648
155LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91375255

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.06751706
2MP0004215_abnormal_myocardial_fiber3.75134015
3MP0000751_myopathy3.64541590
4MP0004084_abnormal_cardiac_muscle3.60829528
5MP0003880_abnormal_central_pattern3.18287762
6MP0003646_muscle_fatigue3.14693049
7MP0003950_abnormal_plasma_membrane2.88662568
8MP0004036_abnormal_muscle_relaxation2.88035512
9MP0005551_abnormal_eye_electrophysiolog2.82438643
10MP0003137_abnormal_impulse_conducting2.69200202
11MP0005330_cardiomyopathy2.57335913
12MP0006072_abnormal_retinal_apoptosis2.31829170
13MP0000749_muscle_degeneration2.31580223
14MP0002972_abnormal_cardiac_muscle2.20796388
15MP0004043_abnormal_pH_regulation2.09033971
16MP0004085_abnormal_heartbeat2.08916158
17MP0000013_abnormal_adipose_tissue2.07596132
18MP0006276_abnormal_autonomic_nervous2.01243175
19MP0005253_abnormal_eye_physiology2.00546329
20MP0001529_abnormal_vocalization1.98675637
21MP0003195_calcinosis1.98494049
22MP0003011_delayed_dark_adaptation1.97370318
23MP0004145_abnormal_muscle_electrophysio1.95332685
24MP0002876_abnormal_thyroid_physiology1.93891225
25MP0005409_darkened_coat_color1.90033295
26MP0005423_abnormal_somatic_nervous1.89889507
27MP0008775_abnormal_heart_ventricle1.88503505
28MP0005620_abnormal_muscle_contractility1.86284781
29MP0008875_abnormal_xenobiotic_pharmacok1.85964381
30MP0005670_abnormal_white_adipose1.78054361
31MP0001905_abnormal_dopamine_level1.77989402
32MP0009046_muscle_twitch1.77487315
33MP0004484_altered_response_of1.75856371
34MP0003136_yellow_coat_color1.69103812
35MP0002272_abnormal_nervous_system1.68283990
36MP0002822_catalepsy1.66339280
37MP0009745_abnormal_behavioral_response1.63300088
38MP0001661_extended_life_span1.61741214
39MP0002138_abnormal_hepatobiliary_system1.57847600
40MP0001486_abnormal_startle_reflex1.57010857
41MP0005085_abnormal_gallbladder_physiolo1.53682982
42MP0003252_abnormal_bile_duct1.52728918
43MP0001544_abnormal_cardiovascular_syste1.52706594
44MP0005385_cardiovascular_system_phenoty1.52706594
45MP0002106_abnormal_muscle_physiology1.52283419
46MP0002234_abnormal_pharynx_morphology1.52187438
47MP0000750_abnormal_muscle_regeneration1.49747659
48MP0002064_seizures1.48802503
49MP0002127_abnormal_cardiovascular_syste1.48186241
50MP0006138_congestive_heart_failure1.45361031
51MP0003635_abnormal_synaptic_transmissio1.45249383
52MP0001188_hyperpigmentation1.43153946
53MP0004087_abnormal_muscle_fiber1.41605198
54MP0002638_abnormal_pupillary_reflex1.40634889
55MP0002572_abnormal_emotion/affect_behav1.37068384
56MP0004142_abnormal_muscle_tone1.36210059
57MP0008872_abnormal_physiological_respon1.36105376
58MP0002735_abnormal_chemical_nociception1.34806326
59MP0003828_pulmonary_edema1.33167262
60MP0003567_abnormal_fetal_cardiomyocyte1.32591657
61MP0004147_increased_porphyrin_level1.29872386
62MP0005171_absent_coat_pigmentation1.28439636
63MP0001968_abnormal_touch/_nociception1.27939801
64MP0000427_abnormal_hair_cycle1.26078795
65MP0005332_abnormal_amino_acid1.25667845
66MP0004270_analgesia1.25501454
67MP0005369_muscle_phenotype1.24843008
68MP0001986_abnormal_taste_sensitivity1.24225572
69MP0002102_abnormal_ear_morphology1.23004314
70MP0004130_abnormal_muscle_cell1.21733168
71MP0005360_urolithiasis1.21290326
72MP0005083_abnormal_biliary_tract1.20173750
73MP0004859_abnormal_synaptic_plasticity1.17987986
74MP0002332_abnormal_exercise_endurance1.17941666
75MP0001440_abnormal_grooming_behavior1.17757370
76MP0004924_abnormal_behavior1.17445400
77MP0005386_behavior/neurological_phenoty1.17445400
78MP0002734_abnormal_mechanical_nocicepti1.14629974
79MP0002067_abnormal_sensory_capabilities1.14510988
80MP0006292_abnormal_olfactory_placode1.14507598
81MP0002063_abnormal_learning/memory/cond1.14486483
82MP0010630_abnormal_cardiac_muscle1.14434556
83MP0004381_abnormal_hair_follicle1.13487946
84MP0000566_synostosis1.13391715
85MP0002229_neurodegeneration1.13220598
86MP0005645_abnormal_hypothalamus_physiol1.12800177
87MP0001984_abnormal_olfaction1.11611089
88MP0004510_myositis1.11427052
89MP0009384_cardiac_valve_regurgitation1.10725773
90MP0005365_abnormal_bile_salt1.08877582
91MP0005195_abnormal_posterior_eye1.08112145
92MP0004742_abnormal_vestibular_system1.07286356
93MP0002752_abnormal_somatic_nervous1.07119746
94MP0001970_abnormal_pain_threshold1.07076664
95MP0010386_abnormal_urinary_bladder1.03316301
96MP0002736_abnormal_nociception_after1.02496338
97MP0000747_muscle_weakness1.01341340
98MP0000759_abnormal_skeletal_muscle0.98006253
99MP0001485_abnormal_pinna_reflex0.97320552
100MP0005623_abnormal_meninges_morphology0.96025420
101MP0001873_stomach_inflammation0.95833657
102MP0000920_abnormal_myelination0.94896315
103MP0001501_abnormal_sleep_pattern0.94692957
104MP0001502_abnormal_circadian_rhythm0.94234619
105MP0002882_abnormal_neuron_morphology0.93013807
106MP0000003_abnormal_adipose_tissue0.91744012
107MP0001765_abnormal_ion_homeostasis0.91523622
108MP0002184_abnormal_innervation0.90266606
109MP0006036_abnormal_mitochondrial_physio0.88568950
110MP0005451_abnormal_body_composition0.88349294
111MP0000778_abnormal_nervous_system0.85604100
112MP0006035_abnormal_mitochondrial_morpho0.85235361
113MP0000538_abnormal_urinary_bladder0.84889572
114MP0000026_abnormal_inner_ear0.83693803
115MP0002090_abnormal_vision0.83296958
116MP0002269_muscular_atrophy0.79182109
117MP0000383_abnormal_hair_follicle0.78279949
118MP0009379_abnormal_foot_pigmentation0.78192279
119MP0002733_abnormal_thermal_nociception0.77978630
120MP0002557_abnormal_social/conspecific_i0.77167410
121MP0008961_abnormal_basal_metabolism0.77099474
122MP0008569_lethality_at_weaning0.76363071
123MP0001963_abnormal_hearing_physiology0.75648532
124MP0002909_abnormal_adrenal_gland0.74856336
125MP0005646_abnormal_pituitary_gland0.74779201
126MP0000230_abnormal_systemic_arterial0.74357576
127MP0005165_increased_susceptibility_to0.73846822
128MP0005379_endocrine/exocrine_gland_phen0.72866622
129MP0001348_abnormal_lacrimal_gland0.72276706
130MP0002693_abnormal_pancreas_physiology0.71695751
131MP0002066_abnormal_motor_capabilities/c0.70776470
132MP0002160_abnormal_reproductive_system0.68066224
133MP0005174_abnormal_tail_pigmentation0.67466426
134MP0009643_abnormal_urine_homeostasis0.65959649
135MP0002163_abnormal_gland_morphology0.65727482
136MP0001756_abnormal_urination0.64719895
137MP0003045_fibrosis0.64342210
138MP0010329_abnormal_lipoprotein_level0.61549409
139MP0005084_abnormal_gallbladder_morpholo0.60627472
140MP0005448_abnormal_energy_balance0.60140860
141MP0002933_joint_inflammation0.60035116
142MP0005410_abnormal_fertilization0.58675617
143MP0000266_abnormal_heart_morphology0.57490615
144MP0001944_abnormal_pancreas_morphology0.57169711

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.33590727
2Acute necrotizing encephalopathy (HP:0006965)4.86915507
3Atrial fibrillation (HP:0005110)4.79859785
4Ventricular tachycardia (HP:0004756)4.76439890
5Syncope (HP:0001279)4.75563535
6Congenital stationary night blindness (HP:0007642)4.66557077
7Primary atrial arrhythmia (HP:0001692)4.52416693
8Abnormal mitochondria in muscle tissue (HP:0008316)4.42856839
9Supraventricular tachycardia (HP:0004755)4.39563174
10Calf muscle hypertrophy (HP:0008981)4.35669876
11Supraventricular arrhythmia (HP:0005115)4.26454120
12Mitochondrial inheritance (HP:0001427)4.23438760
13Muscle hypertrophy of the lower extremities (HP:0008968)4.16873589
14Prolonged QT interval (HP:0001657)4.09358012
15Progressive macrocephaly (HP:0004481)4.02188780
16Abnormality of the calf musculature (HP:0001430)3.87590877
17Optic disc pallor (HP:0000543)3.83864307
18Acute encephalopathy (HP:0006846)3.68070688
19Increased CSF lactate (HP:0002490)3.54270027
20Muscle fiber splitting (HP:0003555)3.52366948
21Central scotoma (HP:0000603)3.49674714
22Hepatocellular necrosis (HP:0001404)3.49588595
23Lipoatrophy (HP:0100578)3.48961971
24Bony spicule pigmentary retinopathy (HP:0007737)3.30234762
25Palpitations (HP:0001962)3.27744883
26Pancreatic cysts (HP:0001737)3.23889247
27Hepatic necrosis (HP:0002605)3.18555666
28Abnormality of the renal cortex (HP:0011035)3.18088411
29Attenuation of retinal blood vessels (HP:0007843)3.17657939
30Right ventricular cardiomyopathy (HP:0011663)3.11015104
31Type II lissencephaly (HP:0007260)3.08427172
32Exercise-induced myalgia (HP:0003738)3.07927618
33Increased hepatocellular lipid droplets (HP:0006565)3.06059610
34Dilated cardiomyopathy (HP:0001644)3.05886306
35Ventricular fibrillation (HP:0001663)3.03213253
36Abnormal EKG (HP:0003115)3.01546235
37Subaortic stenosis (HP:0001682)3.00366011
38Abnormality of the left ventricular outflow tract (HP:0011103)3.00366011
39Ventricular arrhythmia (HP:0004308)2.95136385
40Abnormal rod and cone electroretinograms (HP:0008323)2.93234807
41Left ventricular hypertrophy (HP:0001712)2.92691813
42Abnormality of midbrain morphology (HP:0002418)2.91662191
43Molar tooth sign on MRI (HP:0002419)2.91662191
44Hyperventilation (HP:0002883)2.81024096
45Polydipsia (HP:0001959)2.77034440
46Abnormal drinking behavior (HP:0030082)2.77034440
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.76876618
48Exercise intolerance (HP:0003546)2.76212089
49Lipid accumulation in hepatocytes (HP:0006561)2.75952369
50Nephronophthisis (HP:0000090)2.74163194
51Pancreatic fibrosis (HP:0100732)2.71445272
52Focal motor seizures (HP:0011153)2.69326538
53Tubular atrophy (HP:0000092)2.66644877
54Respiratory failure (HP:0002878)2.64457304
55Renal Fanconi syndrome (HP:0001994)2.64249997
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63322502
57Increased intramyocellular lipid droplets (HP:0012240)2.61993014
58True hermaphroditism (HP:0010459)2.61245747
59Scotoma (HP:0000575)2.60236228
60Severe muscular hypotonia (HP:0006829)2.59115862
61Cerebral edema (HP:0002181)2.54489631
62Hyporeflexia of lower limbs (HP:0002600)2.54460329
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.54144501
64Pheochromocytoma (HP:0002666)2.53110745
65Abnormality of the renal medulla (HP:0100957)2.52846076
66Renal cortical cysts (HP:0000803)2.51072262
67Congenital, generalized hypertrichosis (HP:0004540)2.49186658
68Abnormality of macular pigmentation (HP:0008002)2.44064084
69Bundle branch block (HP:0011710)2.42010802
70Limb dystonia (HP:0002451)2.41115096
71Chorioretinal atrophy (HP:0000533)2.39666738
72Gaze-evoked nystagmus (HP:0000640)2.39539140
73Lactic acidosis (HP:0003128)2.38575291
74Neuroendocrine neoplasm (HP:0100634)2.34442435
75Heart block (HP:0012722)2.34009626
76Decreased central vision (HP:0007663)2.33582872
77Testicular atrophy (HP:0000029)2.30503791
78Exercise-induced muscle cramps (HP:0003710)2.28662994
79Hypoplastic left heart (HP:0004383)2.25790959
80EMG: myopathic abnormalities (HP:0003458)2.25513258
81Genetic anticipation (HP:0003743)2.25502062
82Large for gestational age (HP:0001520)2.25325417
83Cystic liver disease (HP:0006706)2.23947210
84Increased muscle lipid content (HP:0009058)2.23797161
85Leukodystrophy (HP:0002415)2.23585059
86Congenital sensorineural hearing impairment (HP:0008527)2.23571617
87Congenital malformation of the right heart (HP:0011723)2.23481276
88Double outlet right ventricle (HP:0001719)2.23481276
89Pulmonary artery stenosis (HP:0004415)2.23234663
90Ketoacidosis (HP:0001993)2.22988603
91Myotonia (HP:0002486)2.20182321
92Cerebellar dysplasia (HP:0007033)2.18914591
93Progressive external ophthalmoplegia (HP:0000590)2.18647373
94Parakeratosis (HP:0001036)2.15806696
95Atrioventricular block (HP:0001678)2.14616547
96Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.13942046
97Polyuria (HP:0000103)2.13635288
98Patent foramen ovale (HP:0001655)2.13458574
99Abnormal atrioventricular conduction (HP:0005150)2.12617404
100Dyschromatopsia (HP:0007641)2.12122687
101Ketosis (HP:0001946)2.09816439
102Increased corneal curvature (HP:0100692)2.09688797
103Keratoconus (HP:0000563)2.09688797
104Pigmentary retinal degeneration (HP:0001146)2.04506554
105Tachypnea (HP:0002789)2.03236662
1063-Methylglutaconic aciduria (HP:0003535)2.01917903
107Pendular nystagmus (HP:0012043)2.00676353
108Medial flaring of the eyebrow (HP:0010747)1.98803465
109Palmoplantar keratoderma (HP:0000982)1.98797172
110Rib fusion (HP:0000902)1.98719858
111Hyperglycinuria (HP:0003108)1.98390787
112Gait imbalance (HP:0002141)1.97865195
113Hypoplastic heart (HP:0001961)1.94314153
114Increased serum lactate (HP:0002151)1.93651646
115Hypoalbuminemia (HP:0003073)1.92856744
116Abnormal albumin level (HP:0012116)1.92856744
117Abnormality of alanine metabolism (HP:0010916)1.91690489
118Hyperalaninemia (HP:0003348)1.91690489
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91690489
120Entropion (HP:0000621)1.90570517
121Bradycardia (HP:0001662)1.88341656
122X-linked dominant inheritance (HP:0001423)1.88298520
123Asymmetric septal hypertrophy (HP:0001670)1.87551558
124Vaginal atresia (HP:0000148)1.87526006
125Congenital primary aphakia (HP:0007707)1.87409420
126Decreased circulating renin level (HP:0003351)1.85032529
127Abnormal ciliary motility (HP:0012262)1.84785555
128Broad-based gait (HP:0002136)1.84607810
129Progressive microcephaly (HP:0000253)1.84565602
130Late onset (HP:0003584)1.84536915
131Genital tract atresia (HP:0001827)1.83521523
132Respiratory difficulties (HP:0002880)1.83498128
133Submucous cleft hard palate (HP:0000176)1.83362394
134Hypothermia (HP:0002045)1.83320116
135Dysmetric saccades (HP:0000641)1.82663728
136Retinitis pigmentosa (HP:0000510)1.80503794
137Chronic hepatic failure (HP:0100626)1.79179615
138Increased serum pyruvate (HP:0003542)1.78722403
139Abnormality of glycolysis (HP:0004366)1.78722403
140Abnormality of urine glucose concentration (HP:0011016)1.78526321
141Glycosuria (HP:0003076)1.78526321
142Myokymia (HP:0002411)1.78255031
143Abnormality of the foot musculature (HP:0001436)1.77899324
144Progressive cerebellar ataxia (HP:0002073)1.77899205
145Fair hair (HP:0002286)1.77844952
146Abnormal urine output (HP:0012590)1.77491440
147Aplasia/Hypoplasia of the fovea (HP:0008060)1.76602531
148Hypoplasia of the fovea (HP:0007750)1.76602531
149Absent thumb (HP:0009777)1.75774088
150Limb hypertonia (HP:0002509)1.74933751
151Abolished electroretinogram (ERG) (HP:0000550)1.72217554
152Aplasia/Hypoplasia of the patella (HP:0006498)1.71636791

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.97131436
2CASK3.47875460
3MYLK3.13888066
4MUSK2.87060008
5MAPKAPK32.64193937
6TNIK2.63856630
7GRK72.54139850
8PHKG22.48590012
9PHKG12.48590012
10STK392.44888689
11OBSCN2.38561427
12TXK2.13106921
13CAMK2D1.90383331
14MST1R1.89233230
15PINK11.88498763
16LMTK21.85310784
17PBK1.83416644
18STK161.80135798
19INSRR1.74434109
20PNCK1.74083299
21WNK41.72764898
22STK241.70680388
23GRK11.69732697
24PKN11.68901307
25EPHA41.68185157
26PIK3CA1.63751715
27MARK11.53094439
28MAP4K21.50223290
29IRAK21.47665275
30ZAK1.47159308
31TTN1.47024919
32CAMK2A1.45617546
33MAP3K121.44396928
34MAP2K61.44263354
35NTRK31.43306367
36DMPK1.43236840
37MAP2K71.40976753
38NME11.40716875
39EPHA21.38417418
40MAPKAPK51.36046179
41TIE11.35057073
42BMPR1B1.34682844
43MAP3K71.34222621
44ADRBK21.30973497
45GRK51.30524438
46MET1.26620124
47FLT31.26006166
48PRKCE1.23630143
49CAMK2B1.18671660
50CDC42BPA1.18474990
51PKN21.18034567
52BMPR21.16783157
53MAPK131.14821081
54DAPK21.14536540
55NUAK11.12388257
56BCR1.11823004
57STK38L1.09937717
58WNK31.07105794
59PDK31.05911590
60PDK41.05911590
61ROCK21.02245744
62PLK21.01358314
63OXSR10.99783197
64PRPF4B0.99272066
65WNK10.98936118
66PDK20.98747643
67BCKDK0.97827837
68ADRBK10.97652081
69IRAK30.97385799
70ACVR1B0.96193537
71NTRK20.96111741
72UHMK10.94753964
73PRKAA10.94161836
74FGFR20.93943117
75NEK60.92846248
76LIMK10.91914935
77MAP3K40.91776383
78PAK30.90426852
79MST40.85193091
80IRAK10.85148900
81PRKD10.82517043
82MAPK120.80063777
83TAOK30.79655505
84CAMK2G0.79523098
85ROCK10.75913665
86PRKCI0.75274278
87PRKACA0.73891820
88FGR0.70076277
89CAMK10.69522904
90MKNK20.69519298
91TRPM70.68192834
92NME20.67634872
93IKBKB0.66758645
94CDK30.65147540
95FES0.64305506
96ITK0.62102534
97CSNK1G30.60076136
98CHUK0.59159192
99PRKD20.56713976
100PTK2B0.55963732
101NEK20.53767592
102DAPK30.52389933
103AKT30.52047774
104CDK50.50954225
105RPS6KA50.47061735
106PRKACB0.46488647
107CSNK1G20.46432224
108CAMKK20.46420656
109TLK10.45179926
110PRKG10.44781493
111FER0.42758984
112NTRK10.42488602
113MAP2K40.42219560
114IRAK40.42054283
115RIPK40.41838028
116ILK0.41492972
117EPHA30.41007181
118CSNK1A1L0.40903159
119CSNK1G10.40773287
120PRKCQ0.40246268
121CAMK40.38822744
122PRKCA0.37228240
123YES10.36571284
124PRKAA20.36389630
125PRKCG0.35508895
126SGK2230.35402640
127SGK4940.35402640
128DYRK1A0.35261680
129RPS6KA60.34790498
130KDR0.34772739
131PRKCH0.34321802
132DYRK20.33742328
133VRK10.32513679
134PRKACG0.32375590
135MAPK150.32273578
136NEK10.31733325
137MAPK110.30414963
138MAP2K10.29370393
139RPS6KB20.27420291
140CSNK1A10.26817522
141STK30.26747622
142STK110.25872499
143FGFR10.25481279

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.22942759
2Phototransduction_Homo sapiens_hsa047445.13447960
3Parkinsons disease_Homo sapiens_hsa050124.58223887
4Cardiac muscle contraction_Homo sapiens_hsa042604.06522823
5Alzheimers disease_Homo sapiens_hsa050103.60745155
6Huntingtons disease_Homo sapiens_hsa050163.11711747
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.70498682
8Dilated cardiomyopathy_Homo sapiens_hsa054142.46436448
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.35552548
10Fatty acid elongation_Homo sapiens_hsa000622.08837924
11Nicotine addiction_Homo sapiens_hsa050332.04209879
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93795089
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.82291811
14Tryptophan metabolism_Homo sapiens_hsa003801.71947039
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.71335588
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67141048
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.66920593
18Serotonergic synapse_Homo sapiens_hsa047261.64501563
19Sulfur relay system_Homo sapiens_hsa041221.59408957
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54261180
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51338987
22Taste transduction_Homo sapiens_hsa047421.47957330
23Morphine addiction_Homo sapiens_hsa050321.47894123
24Nitrogen metabolism_Homo sapiens_hsa009101.47789985
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47403445
26GABAergic synapse_Homo sapiens_hsa047271.45483450
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.43373559
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.41707325
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41235773
30Circadian entrainment_Homo sapiens_hsa047131.40944549
31ABC transporters_Homo sapiens_hsa020101.38502332
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37116733
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36675812
34Collecting duct acid secretion_Homo sapiens_hsa049661.33477205
35Caffeine metabolism_Homo sapiens_hsa002321.33456032
36Glutamatergic synapse_Homo sapiens_hsa047241.33203450
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28267115
38Calcium signaling pathway_Homo sapiens_hsa040201.25594227
39Olfactory transduction_Homo sapiens_hsa047401.25530995
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21358863
41Vitamin B6 metabolism_Homo sapiens_hsa007501.15474157
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15044762
43Retinol metabolism_Homo sapiens_hsa008301.09221512
44Peroxisome_Homo sapiens_hsa041461.08141304
45Amphetamine addiction_Homo sapiens_hsa050311.07895105
46Ether lipid metabolism_Homo sapiens_hsa005651.06382630
47Renin secretion_Homo sapiens_hsa049241.04794379
48Cocaine addiction_Homo sapiens_hsa050301.03296153
49Chemical carcinogenesis_Homo sapiens_hsa052041.01047855
50Synaptic vesicle cycle_Homo sapiens_hsa047211.00719136
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00465568
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.99896577
53Arginine biosynthesis_Homo sapiens_hsa002200.98022838
54Bile secretion_Homo sapiens_hsa049760.97906408
55Dopaminergic synapse_Homo sapiens_hsa047280.97568676
56Cholinergic synapse_Homo sapiens_hsa047250.96864850
57Ribosome_Homo sapiens_hsa030100.95148865
58Fat digestion and absorption_Homo sapiens_hsa049750.95116663
59One carbon pool by folate_Homo sapiens_hsa006700.92787634
60Insulin secretion_Homo sapiens_hsa049110.92399668
61Selenocompound metabolism_Homo sapiens_hsa004500.91978362
62Propanoate metabolism_Homo sapiens_hsa006400.90817572
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90358709
64Oxytocin signaling pathway_Homo sapiens_hsa049210.89409817
65beta-Alanine metabolism_Homo sapiens_hsa004100.82392066
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82242180
67Gastric acid secretion_Homo sapiens_hsa049710.81934377
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.81924340
69Primary immunodeficiency_Homo sapiens_hsa053400.81416709
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81237568
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81192865
72Mineral absorption_Homo sapiens_hsa049780.80122176
73PPAR signaling pathway_Homo sapiens_hsa033200.79286562
74Linoleic acid metabolism_Homo sapiens_hsa005910.78485536
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77628709
76Salivary secretion_Homo sapiens_hsa049700.75446625
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74716950
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.73670723
79Arachidonic acid metabolism_Homo sapiens_hsa005900.71016720
80Axon guidance_Homo sapiens_hsa043600.70436931
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70197052
82Homologous recombination_Homo sapiens_hsa034400.69586352
83RNA polymerase_Homo sapiens_hsa030200.69057475
84Long-term depression_Homo sapiens_hsa047300.66163087
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65768409
86cAMP signaling pathway_Homo sapiens_hsa040240.65255412
87Vibrio cholerae infection_Homo sapiens_hsa051100.64039122
88Protein export_Homo sapiens_hsa030600.63770837
89Long-term potentiation_Homo sapiens_hsa047200.62593975
90Glycerolipid metabolism_Homo sapiens_hsa005610.61976976
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61539792
92Sphingolipid metabolism_Homo sapiens_hsa006000.60817285
93Fanconi anemia pathway_Homo sapiens_hsa034600.60614217
94Circadian rhythm_Homo sapiens_hsa047100.58894842
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58690329
96Fatty acid metabolism_Homo sapiens_hsa012120.58462423
97RNA degradation_Homo sapiens_hsa030180.57793659
98Sulfur metabolism_Homo sapiens_hsa009200.57269591
99Rheumatoid arthritis_Homo sapiens_hsa053230.57055033
100Ovarian steroidogenesis_Homo sapiens_hsa049130.55914736
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54214285
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52105993
103Butanoate metabolism_Homo sapiens_hsa006500.50872765
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50673632
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49655930
106Graft-versus-host disease_Homo sapiens_hsa053320.48541755
107Lysine degradation_Homo sapiens_hsa003100.47833369
108Tyrosine metabolism_Homo sapiens_hsa003500.47670531
109Metabolic pathways_Homo sapiens_hsa011000.46172214
110Arginine and proline metabolism_Homo sapiens_hsa003300.45946147
111Proteasome_Homo sapiens_hsa030500.45758143
112Thyroid hormone synthesis_Homo sapiens_hsa049180.45171670
113Pyruvate metabolism_Homo sapiens_hsa006200.44411030
114GnRH signaling pathway_Homo sapiens_hsa049120.44344060
115Phenylalanine metabolism_Homo sapiens_hsa003600.44024508
116Viral myocarditis_Homo sapiens_hsa054160.43208342
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42546882
118Fatty acid degradation_Homo sapiens_hsa000710.40328582
119Purine metabolism_Homo sapiens_hsa002300.39709715
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39564007
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38987509
122Gap junction_Homo sapiens_hsa045400.38180884
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35342380
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32559378
125Pancreatic secretion_Homo sapiens_hsa049720.32246313
126Ras signaling pathway_Homo sapiens_hsa040140.29684438
127Autoimmune thyroid disease_Homo sapiens_hsa053200.29627741
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28468746
129Melanogenesis_Homo sapiens_hsa049160.28326611
130Basal transcription factors_Homo sapiens_hsa030220.27096754
131Tight junction_Homo sapiens_hsa045300.27076247
132Carbon metabolism_Homo sapiens_hsa012000.22511770
133ECM-receptor interaction_Homo sapiens_hsa045120.18469251
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.18004655
135MAPK signaling pathway_Homo sapiens_hsa040100.16722803
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15660871
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15267954
138Fatty acid biosynthesis_Homo sapiens_hsa000610.15236769
139African trypanosomiasis_Homo sapiens_hsa051430.15205732
140Glucagon signaling pathway_Homo sapiens_hsa049220.14835467
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.11285886
142Histidine metabolism_Homo sapiens_hsa003400.10952394

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