ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis (GO:0007140)	9.99858622
2	meiotic nuclear division (GO:0007126)	8.69376257
3	DNA methylation involved in gamete generation (GO:0043046)	8.54129058
4	meiotic cell cycle process (GO:1903046)	7.70595588
5	positive regulation of meiosis (GO:0045836)	7.50007434
6	sister chromatid cohesion (GO:0007062)	7.17858092
7	positive regulation of meiotic cell cycle (GO:0051446)	6.97450564
8	reciprocal DNA recombination (GO:0035825)	6.93745033
9	reciprocal meiotic recombination (GO:0007131)	6.93745033
10	resolution of meiotic recombination intermediates (GO:0000712)	6.56844340
11	meiotic chromosome segregation (GO:0045132)	5.38975971
12	regulation of meiotic cell cycle (GO:0051445)	4.73458491
13	female gamete generation (GO:0007292)	4.39365416
14	gene silencing by RNA (GO:0031047)	4.32392733
15	negative regulation of meiosis (GO:0045835)	4.28728897
16	acrosome assembly (GO:0001675)	4.15419043
17	mitotic sister chromatid cohesion (GO:0007064)	4.06290254
18	histone H3-K36 demethylation (GO:0070544)	3.99046872
19	sex differentiation (GO:0007548)	3.95536018
20	oogenesis (GO:0048477)	3.83170215
21	regulation of meiosis (GO:0040020)	3.76167575
22	histone exchange (GO:0043486)	3.62264408
23	negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)	3.61466377
24	positive regulation of male gonad development (GO:2000020)	3.51026710
25	DNA biosynthetic process (GO:0071897)	3.48600725
26	response to pheromone (GO:0019236)	3.46278072
27	histone H3-K9 demethylation (GO:0033169)	3.45762232
28	protein neddylation (GO:0045116)	3.44568053
29	histone H2A acetylation (GO:0043968)	3.35549742
30	reproductive system development (GO:0061458)	3.26256778
31	meiotic cell cycle (GO:0051321)	3.24530290
32	regulation of male gonad development (GO:2000018)	3.20618328
33	mitochondrial DNA replication (GO:0006264)	3.18409927
34	interkinetic nuclear migration (GO:0022027)	3.18159156
35	glycerophospholipid catabolic process (GO:0046475)	3.17998243
36	male sex determination (GO:0030238)	3.13377983
37	oocyte development (GO:0048599)	3.12572012
38	germ cell migration (GO:0008354)	3.11844786
39	negative regulation of meiotic cell cycle (GO:0051447)	3.08317778
40	DNA alkylation (GO:0006305)	3.07721963
41	DNA methylation (GO:0006306)	3.07721963
42	nucleotide transmembrane transport (GO:1901679)	3.07079961
43	regulation of histone H3-K9 methylation (GO:0051570)	3.05505791
44	negative regulation of gene silencing (GO:0060969)	3.01134046
45	intraciliary transport (GO:0042073)	3.00774928
46	positive regulation of cAMP-mediated signaling (GO:0043950)	2.97620519
47	fertilization (GO:0009566)	2.95190413
48	platelet dense granule organization (GO:0060155)	2.94903160
49	proteasome assembly (GO:0043248)	2.93862418
50	chromosome organization (GO:0051276)	2.91141026
51	microtubule severing (GO:0051013)	2.78899492
52	CENP-A containing nucleosome assembly (GO:0034080)	2.76785957
53	regulation of DNA endoreduplication (GO:0032875)	2.74952138
54	negative regulation of heart rate (GO:0010459)	2.69631433
55	chromatin remodeling at centromere (GO:0031055)	2.66041548
56	nuclear division (GO:0000280)	2.63333475
57	positive regulation of response to oxidative stress (GO:1902884)	2.61674148
58	positive regulation of cellular response to oxidative stress (GO:1900409)	2.61674148
59	spermatid development (GO:0007286)	2.59301633
60	regulation of microtubule-based movement (GO:0060632)	2.57866066
61	male gamete generation (GO:0048232)	2.56092219
62	gamete generation (GO:0007276)	2.55592411
63	spermatogenesis (GO:0007283)	2.55438759
64	germ cell development (GO:0007281)	2.53235512
65	negative regulation of appetite (GO:0032099)	2.52348035
66	negative regulation of response to food (GO:0032096)	2.52348035
67	response to hydroperoxide (GO:0033194)	2.51540767
68	DNA methylation or demethylation (GO:0044728)	2.50440646
69	binding of sperm to zona pellucida (GO:0007339)	2.49836335
70	seminiferous tubule development (GO:0072520)	2.47245694
71	protein maturation by protein folding (GO:0022417)	2.46945629
72	organelle fission (GO:0048285)	2.46434112
73	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.45709022
74	regulation of cilium movement (GO:0003352)	2.45249385
75	gene silencing (GO:0016458)	2.44464591
76	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.42564437
77	protein localization to chromosome (GO:0034502)	2.41708283
78	DNA-dependent DNA replication (GO:0006261)	2.38835729
79	somite rostral/caudal axis specification (GO:0032525)	2.37377547
80	positive regulation of protein homodimerization activity (GO:0090073)	2.36128954
81	Sertoli cell development (GO:0060009)	2.33025404
82	DNA recombination (GO:0006310)	2.30878343
83	sperm-egg recognition (GO:0035036)	2.29716128
84	DNA modification (GO:0006304)	2.28745546
85	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.28626336
86	negative regulation of execution phase of apoptosis (GO:1900118)	2.28424778
87	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.25279538
88	regulation of protein glycosylation (GO:0060049)	2.18647462
89	axoneme assembly (GO:0035082)	2.17290643
90	attachment of spindle microtubules to kinetochore (GO:0008608)	2.15598112
91	sperm motility (GO:0030317)	2.11457029
92	synapsis (GO:0007129)	15.4691703
93	chromosome organization involved in meiosis (GO:0070192)	13.3947049
94	synaptonemal complex assembly (GO:0007130)	12.4288749
95	male meiosis I (GO:0007141)	12.4233545
96	piRNA metabolic process (GO:0034587)	12.0500932
97	regulation of meiosis I (GO:0060631)	11.7051693
98	synaptonemal complex organization (GO:0070193)	11.2507254
99	meiosis I (GO:0007127)	10.2772764
100	DNA synthesis involved in DNA repair (GO:0000731)	10.2290171

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.54780650
2	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	4.39673014
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.63287260
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.06155720
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.75093127
6	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.58983392
7	VDR_22108803_ChIP-Seq_LS180_Human	2.40782186
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.34955752
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.26662046
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.23539711
11	RNF2_27304074_Chip-Seq_NSC_Mouse	2.22173224
12	HTT_18923047_ChIP-ChIP_STHdh_Human	2.14636688
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.08168943
14	BCAT_22108803_ChIP-Seq_LS180_Human	1.98805524
15	EWS_26573619_Chip-Seq_HEK293_Human	1.89685743
16	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.80260596
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.76961523
18	FUS_26573619_Chip-Seq_HEK293_Human	1.74533066
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69719166
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.68690356
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.60358308
22	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.60115945
23	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.60115945
24	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.58190934
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56996733
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.55783692
27	P300_19829295_ChIP-Seq_ESCs_Human	1.53455149
28	GBX2_23144817_ChIP-Seq_PC3_Human	1.51044528
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.50210252
30	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.49973651
31	STAT3_23295773_ChIP-Seq_U87_Human	1.45725027
32	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.44358857
33	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.41789099
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40855686
35	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.39163857
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38666802
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38611178
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38611178
39	AR_25329375_ChIP-Seq_VCAP_Human	1.38583075
40	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.33811457
41	TCF4_23295773_ChIP-Seq_U87_Human	1.33156548
42	GATA3_26560356_Chip-Seq_TH1_Human	1.29735583
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.28308196
44	CDX2_22108803_ChIP-Seq_LS180_Human	1.26944280
45	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.25598163
46	AR_20517297_ChIP-Seq_VCAP_Human	1.25448802
47	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.24730833
48	HOXB7_26014856_ChIP-Seq_BT474_Human	1.23582895
49	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.22813556
50	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.22253434
51	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.21366341
52	VDR_23849224_ChIP-Seq_CD4+_Human	1.20280946
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20083365
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.18639722
55	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.18341941
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17920989
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16993674
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16574224
59	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.15257304
60	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14341184
61	GATA1_22025678_ChIP-Seq_K562_Human	1.11762311
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.11717271
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11717271
64	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.11551054
65	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.11293853
66	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.10540466
67	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10482431
68	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10095704
69	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08080777
70	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08078045
71	PHF8_20622853_ChIP-Seq_HELA_Human	1.06600702
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.06368531
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05983788
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05299258
75	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.02539988
76	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02284360
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01806742
78	MYC_19829295_ChIP-Seq_ESCs_Human	1.01303593
79	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.00425964
80	ETV1_20927104_ChIP-Seq_GIST48_Human	1.00347056
81	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00061643
82	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99404545
83	IRF1_19129219_ChIP-ChIP_H3396_Human	0.99395725
84	ERG_20517297_ChIP-Seq_VCAP_Human	0.99234863
85	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.99181521
86	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.99045092
87	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.98026449
88	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97502592
89	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96419299
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95897516
91	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95748808
92	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.95479371
93	RBPJ_21746931_ChIP-Seq_IB4_Human	0.94852816
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94457586
95	STAT1_20625510_ChIP-Seq_HELA_Human	0.94229734
96	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.93477257
97	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.93172648
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.93025894
99	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92636823
100	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.91857661

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	8.95589910
2	MP0008058_abnormal_DNA_repair	4.76961587
3	MP0002210_abnormal_sex_determination	4.33271880
4	MP0001929_abnormal_gametogenesis	3.72354646
5	MP0008004_abnormal_stomach_pH	3.35023330
6	MP0001145_abnormal_male_reproductive	3.31885327
7	MP0002160_abnormal_reproductive_system	3.18624876
8	MP0000653_abnormal_sex_gland	3.13702742
9	MP0003698_abnormal_male_reproductive	3.12467537
10	MP0005464_abnormal_platelet_physiology	2.95451411
11	MP0002876_abnormal_thyroid_physiology	2.53108104
12	MP0002837_dystrophic_cardiac_calcinosis	2.47037175
13	MP0005174_abnormal_tail_pigmentation	2.37402503
14	MP0001119_abnormal_female_reproductive	2.24615741
15	MP0005410_abnormal_fertilization	2.21676861
16	MP0005389_reproductive_system_phenotype	2.17607291
17	MP0003183_abnormal_peptide_metabolism	2.00571412
18	MP0000015_abnormal_ear_pigmentation	1.88607794
19	MP0000013_abnormal_adipose_tissue	1.69607886
20	MP0002161_abnormal_fertility/fecundity	1.68544159
21	MP0006035_abnormal_mitochondrial_morpho	1.62492013
22	MP0005451_abnormal_body_composition	1.61751077
23	MP0000569_abnormal_digit_pigmentation	1.56522133
24	MP0004215_abnormal_myocardial_fiber	1.55491232
25	MP0010094_abnormal_chromosome_stability	1.53739867
26	MP0003699_abnormal_female_reproductive	1.51720788
27	MP0006036_abnormal_mitochondrial_physio	1.49229768
28	MP0008057_abnormal_DNA_replication	1.46977440
29	MP0001986_abnormal_taste_sensitivity	1.43756298
30	MP0008995_early_reproductive_senescence	1.43558237
31	MP0005645_abnormal_hypothalamus_physiol	1.38262486
32	MP0001984_abnormal_olfaction	1.34777858
33	MP0003646_muscle_fatigue	1.30788881
34	MP0005646_abnormal_pituitary_gland	1.27184518
35	MP0002653_abnormal_ependyma_morphology	1.25171116
36	MP0005379_endocrine/exocrine_gland_phen	1.22011474
37	MP0004147_increased_porphyrin_level	1.18617894
38	MP0000383_abnormal_hair_follicle	1.16921548
39	MP0005551_abnormal_eye_electrophysiolog	1.16579295
40	MP0000358_abnormal_cell_content/	1.15561531
41	MP0000230_abnormal_systemic_arterial	1.14998511
42	MP0008872_abnormal_physiological_respon	1.13999087
43	MP0002254_reproductive_system_inflammat	1.13112602
44	MP0005084_abnormal_gallbladder_morpholo	1.08331685
45	MP0001485_abnormal_pinna_reflex	1.08218541
46	MP0002095_abnormal_skin_pigmentation	1.07583320
47	MP0009780_abnormal_chondrocyte_physiolo	1.06060864
48	MP0002132_abnormal_respiratory_system	1.04884693
49	MP0002736_abnormal_nociception_after	1.01147716
50	MP0004019_abnormal_vitamin_homeostasis	0.98343171
51	MP0001764_abnormal_homeostasis	0.94024651
52	MP0003786_premature_aging	0.93725053
53	MP0005058_abnormal_lysosome_morphology	0.93366486
54	MP0010386_abnormal_urinary_bladder	0.93167233
55	MP0002163_abnormal_gland_morphology	0.92646282
56	MP0001944_abnormal_pancreas_morphology	0.88099284
57	MP0002909_abnormal_adrenal_gland	0.87975553
58	MP0001919_abnormal_reproductive_system	0.87766854
59	MP0001968_abnormal_touch/_nociception	0.83773054
60	MP0001756_abnormal_urination	0.82583814
61	MP0003879_abnormal_hair_cell	0.79897008
62	MP0002693_abnormal_pancreas_physiology	0.79367962
63	MP0008007_abnormal_cellular_replicative	0.73924660
64	MP0001879_abnormal_lymphatic_vessel	0.73732262
65	MP0005332_abnormal_amino_acid	0.73343695
66	MP0005075_abnormal_melanosome_morpholog	0.72806011
67	MP0009046_muscle_twitch	0.72498649
68	MP0000372_irregular_coat_pigmentation	0.72064910
69	MP0002102_abnormal_ear_morphology	0.71126664
70	MP0010329_abnormal_lipoprotein_level	0.70389876
71	MP0002139_abnormal_hepatobiliary_system	0.70217285
72	MP0003718_maternal_effect	0.69582950
73	MP0005367_renal/urinary_system_phenotyp	0.68606583
74	MP0000516_abnormal_urinary_system	0.68606583
75	MP0005636_abnormal_mineral_homeostasis	0.67252597
76	MP0006054_spinal_hemorrhage	0.67107456
77	MP0005448_abnormal_energy_balance	0.64936580
78	MP0003283_abnormal_digestive_organ	0.63985787
79	MP0005670_abnormal_white_adipose	0.63845858
80	MP0001765_abnormal_ion_homeostasis	0.62653333
81	MP0004133_heterotaxia	0.62454151
82	MP0003567_abnormal_fetal_cardiomyocyte	0.62335120
83	MP0002075_abnormal_coat/hair_pigmentati	0.62093591
84	MP0005253_abnormal_eye_physiology	0.60965013
85	MP0005666_abnormal_adipose_tissue	0.60123801
86	MP0004142_abnormal_muscle_tone	0.59896152
87	MP0000427_abnormal_hair_cycle	0.58794338
88	MP0001666_abnormal_nutrient_absorption	0.58617794
89	MP0002078_abnormal_glucose_homeostasis	0.58553163
90	MP0004885_abnormal_endolymph	0.58110192
91	MP0004036_abnormal_muscle_relaxation	0.56133032
92	MP0001188_hyperpigmentation	0.56109728
93	MP0003890_abnormal_embryonic-extraembry	0.56097440
94	MP0002638_abnormal_pupillary_reflex	0.53494497
95	MP0005535_abnormal_body_temperature	0.53133886
96	MP0002733_abnormal_thermal_nociception	0.52044907
97	MP0001502_abnormal_circadian_rhythm	0.51760663
98	MP0003953_abnormal_hormone_level	0.51220269
99	MP0004084_abnormal_cardiac_muscle	0.50191239
100	MP0002938_white_spotting	0.50186047

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Spontaneous abortion (HP:0005268)	5.47887157
2	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.77810907
3	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.77810907
4	Azoospermia (HP:0000027)	4.46477804
5	Hand muscle atrophy (HP:0009130)	3.79305513
6	Abnormal spermatogenesis (HP:0008669)	3.52004530
7	Impaired vibration sensation in the lower limbs (HP:0002166)	3.51813483
8	Tubulointerstitial nephritis (HP:0001970)	3.48938683
9	Petechiae (HP:0000967)	3.46445034
10	Abnormality of the corticospinal tract (HP:0002492)	3.44635453
11	Gonadotropin excess (HP:0000837)	3.27227452
12	Nephronophthisis (HP:0000090)	3.26028231
13	Prolonged bleeding time (HP:0003010)	3.19025813
14	Hypoproteinemia (HP:0003075)	3.04399685
15	Osteomalacia (HP:0002749)	3.01862603
16	Intestinal atresia (HP:0011100)	2.93612207
17	Central scotoma (HP:0000603)	2.85137488
18	Upper limb muscle weakness (HP:0003484)	2.84877877
19	Volvulus (HP:0002580)	2.77359621
20	Menorrhagia (HP:0000132)	2.76013385
21	Scotoma (HP:0000575)	2.75636124
22	Increased mean platelet volume (HP:0011877)	2.74871777
23	B lymphocytopenia (HP:0010976)	2.73649108
24	Short tibia (HP:0005736)	2.70232296
25	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.69568382
26	Abnormality of the renal medulla (HP:0100957)	2.68215834
27	Distal upper limb amyotrophy (HP:0007149)	2.62183918
28	Upper limb amyotrophy (HP:0009129)	2.62183918
29	Oligodactyly (hands) (HP:0001180)	2.61649471
30	Hyperlipoproteinemia (HP:0010980)	2.56600092
31	Hypoplasia of the thymus (HP:0000778)	2.53041290
32	Panhypogammaglobulinemia (HP:0003139)	2.45511983
33	Impaired vibratory sensation (HP:0002495)	2.41353092
34	Abnormal platelet volume (HP:0011876)	2.38281983
35	Rimmed vacuoles (HP:0003805)	2.32240389
36	Abnormality of B cell number (HP:0010975)	2.31655736
37	Male pseudohermaphroditism (HP:0000037)	2.23658741
38	Polyphagia (HP:0002591)	2.22271186
39	Purpura (HP:0000979)	2.21137713
40	Congenital malformation of the right heart (HP:0011723)	2.19536482
41	Double outlet right ventricle (HP:0001719)	2.19536482
42	Acanthocytosis (HP:0001927)	2.19366612
43	Tubular atrophy (HP:0000092)	2.17264774
44	Neonatal short-limb short stature (HP:0008921)	2.16247526
45	Abnormality of the vocal cords (HP:0008777)	2.15701518
46	Abnormality of the renal cortex (HP:0011035)	2.15538199
47	Thyroiditis (HP:0100646)	2.14712537
48	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	2.12354303
49	Conjunctival telangiectasia (HP:0000524)	2.11668292
50	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.08759247
51	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.08759247
52	Tubulointerstitial abnormality (HP:0001969)	2.08575034
53	Postaxial foot polydactyly (HP:0001830)	2.04286250
54	Combined immunodeficiency (HP:0005387)	2.04000862
55	Proximal tubulopathy (HP:0000114)	2.02122172
56	Hypoplastic iliac wings (HP:0002866)	2.00968695
57	Abnormality of the fovea (HP:0000493)	1.98502640
58	Molar tooth sign on MRI (HP:0002419)	1.98178085
59	Abnormality of midbrain morphology (HP:0002418)	1.98178085
60	Severe visual impairment (HP:0001141)	1.95250497
61	Synostosis of carpal bones (HP:0005048)	1.90958197
62	Abnormality of urine glucose concentration (HP:0011016)	1.90490635
63	Glycosuria (HP:0003076)	1.90490635
64	Chronic hepatic failure (HP:0100626)	1.86982799
65	Pancreatic islet-cell hyperplasia (HP:0004510)	1.85462082
66	Stage 5 chronic kidney disease (HP:0003774)	1.85252531
67	Insulin-resistant diabetes mellitus (HP:0000831)	1.85068522
68	Epistaxis (HP:0000421)	1.83365067
69	Fair hair (HP:0002286)	1.82862667
70	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.81955237
71	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.80394029
72	Abnormality of the lower motor neuron (HP:0002366)	1.80029603
73	Abnormality of macular pigmentation (HP:0008002)	1.79979360
74	Facial cleft (HP:0002006)	1.79399472
75	Renal cortical cysts (HP:0000803)	1.75381539
76	Abnormality of the epiphyses of the hand (HP:0005924)	1.73812254
77	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.73096770
78	Gout (HP:0001997)	1.72427923
79	Poikilocytosis (HP:0004447)	1.70361755
80	Progressive inability to walk (HP:0002505)	1.70282748
81	Hyperglycinemia (HP:0002154)	1.70149237
82	Urinary bladder sphincter dysfunction (HP:0002839)	1.70058644
83	Facial diplegia (HP:0001349)	1.69534348
84	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.69410718
85	Albinism (HP:0001022)	1.69403294
86	Gaze-evoked nystagmus (HP:0000640)	1.69004828
87	Congenital stationary night blindness (HP:0007642)	1.68751703
88	Abnormal ciliary motility (HP:0012262)	1.68416929
89	Metaphyseal cupping (HP:0003021)	1.66367569
90	Gingival bleeding (HP:0000225)	1.65193419
91	Severe combined immunodeficiency (HP:0004430)	1.64340522
92	Erythroderma (HP:0001019)	1.64223846
93	Abnormality of vitamin B metabolism (HP:0004340)	1.62217321
94	Abnormality of the basal ganglia (HP:0002134)	1.61432342
95	Chromsome breakage (HP:0040012)	1.59545165
96	Medial flaring of the eyebrow (HP:0010747)	1.58925651
97	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.58605870
98	Urinary urgency (HP:0000012)	1.58032772
99	Vertebral arch anomaly (HP:0008438)	1.57958824
100	Renal Fanconi syndrome (HP:0001994)	1.57938256

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	5.75919277
2	CDK19	3.85950874
3	MST4	3.72158982
4	RIPK4	3.15632834
5	FRK	3.09723745
6	PDK2	2.98842304
7	STK38L	2.83735571
8	BMPR1B	2.38264971
9	PTK2B	2.07070712
10	NEK9	2.03533655
11	OXSR1	1.93873521
12	MAP4K2	1.90852309
13	ACVR1B	1.89192723
14	NLK	1.77800427
15	YES1	1.72090018
16	WNK4	1.65351946
17	MAP3K2	1.62377141
18	PLK2	1.59684777
19	PRKD3	1.58203630
20	MAPK13	1.55412038
21	BMX	1.55323881
22	LATS1	1.48310207
23	ZAK	1.47731485
24	GRK1	1.47001619
25	PLK1	1.38490800
26	MET	1.37981692
27	MAP3K3	1.37886926
28	WEE1	1.28945419
29	PHKG2	1.28828162
30	PHKG1	1.28828162
31	STK3	1.28041333
32	ADRBK2	1.27934796
33	TTK	1.19476663
34	STK38	1.15530094
35	PLK4	1.12312656
36	WNK3	1.05250311
37	TNK2	1.05183312
38	EIF2AK3	1.04964720
39	PAK3	1.04587525
40	FER	1.03490107
41	PINK1	1.01064151
42	BRSK2	0.98606762
43	NUAK1	0.97643906
44	TLK1	0.94877743
45	PRKCI	0.92817301
46	MYLK	0.91082096
47	NTRK3	0.90102397
48	VRK1	0.84641428
49	TRIM28	0.80574663
50	CAMK1G	0.78289241
51	MAP2K3	0.76471228
52	PRKD2	0.74469106
53	PLK3	0.73154530
54	WNK1	0.69897050
55	IRAK1	0.69795444
56	TEC	0.69472210
57	PIK3CG	0.68272618
58	PDPK1	0.68146177
59	STK39	0.67120772
60	MAP2K2	0.66355655
61	DYRK2	0.65342060
62	BRSK1	0.64659473
63	TNIK	0.63276640
64	CSF1R	0.61959036
65	CSNK1G1	0.58523589
66	PDK1	0.58100016
67	EPHA3	0.57577428
68	SGK2	0.54620098
69	CSNK1G2	0.53230225
70	RPS6KB1	0.51880272
71	INSRR	0.49284348
72	ATR	0.48901503
73	PRKCE	0.48583496
74	DAPK2	0.48432351
75	RET	0.47228852
76	ATM	0.45059394
77	BRAF	0.44454457
78	CHEK1	0.43778839
79	TAOK3	0.43302511
80	FGFR3	0.43193961
81	MAP3K4	0.42413692
82	MAP3K12	0.39609142
83	CASK	0.39550797
84	PDGFRB	0.38673192
85	FLT3	0.36494229
86	AKT2	0.34423984
87	AURKA	0.33366581
88	SGK1	0.33185535
89	PRKG1	0.32774566
90	MAPKAPK3	0.32399561
91	PRKCG	0.32370125
92	SGK494	0.32291752
93	SGK223	0.32291752
94	PRKACB	0.30349122
95	ADRBK1	0.29611580
96	CDK9	0.28475851
97	FGR	0.28286145
98	STK24	0.28263692
99	CSNK1G3	0.27294935
100	BTK	0.24942713

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	5.52954281
2	Mismatch repair_Homo sapiens_hsa03430	3.26184211
3	Non-homologous end-joining_Homo sapiens_hsa03450	3.16176107
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.63842652
5	Oocyte meiosis_Homo sapiens_hsa04114	2.60699917
6	Regulation of autophagy_Homo sapiens_hsa04140	2.40775781
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.27725250
8	Basal transcription factors_Homo sapiens_hsa03022	2.26184206
9	Propanoate metabolism_Homo sapiens_hsa00640	2.20065078
10	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.94998125
11	Phototransduction_Homo sapiens_hsa04744	1.86079046
12	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.82612081
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.76278456
14	Caffeine metabolism_Homo sapiens_hsa00232	1.74853848
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.70622227
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.66639394
17	Cell cycle_Homo sapiens_hsa04110	1.65985014
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64710323
19	DNA replication_Homo sapiens_hsa03030	1.64212773
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.62288770
21	Fatty acid elongation_Homo sapiens_hsa00062	1.60135459
22	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.57633671
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.54803267
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.53886095
25	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.43462936
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.42832211
27	Collecting duct acid secretion_Homo sapiens_hsa04966	1.39392174
28	Glutathione metabolism_Homo sapiens_hsa00480	1.37846307
29	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.36820992
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.34546733
31	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.33745257
32	Platelet activation_Homo sapiens_hsa04611	1.32263796
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.28824630
34	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.24404858
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.12948721
36	RNA transport_Homo sapiens_hsa03013	1.08850174
37	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.05671058
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.04192170
39	Retinol metabolism_Homo sapiens_hsa00830	1.00570250
40	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.98962582
41	Sphingolipid metabolism_Homo sapiens_hsa00600	0.97646416
42	Olfactory transduction_Homo sapiens_hsa04740	0.96262373
43	Ether lipid metabolism_Homo sapiens_hsa00565	0.95041581
44	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.94494761
45	Fat digestion and absorption_Homo sapiens_hsa04975	0.93971220
46	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.93571649
47	Sulfur relay system_Homo sapiens_hsa04122	0.92333091
48	Sulfur metabolism_Homo sapiens_hsa00920	0.92234722
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.91370527
50	ABC transporters_Homo sapiens_hsa02010	0.91342901
51	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.89761119
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.85875817
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.84811567
54	Calcium signaling pathway_Homo sapiens_hsa04020	0.84604503
55	Glucagon signaling pathway_Homo sapiens_hsa04922	0.83870456
56	Purine metabolism_Homo sapiens_hsa00230	0.80758973
57	RNA degradation_Homo sapiens_hsa03018	0.79934615
58	Parkinsons disease_Homo sapiens_hsa05012	0.79607073
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.76888531
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.76069432
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75963802
62	Base excision repair_Homo sapiens_hsa03410	0.75217446
63	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.74978394
64	Butanoate metabolism_Homo sapiens_hsa00650	0.73057249
65	Circadian rhythm_Homo sapiens_hsa04710	0.70759446
66	Type I diabetes mellitus_Homo sapiens_hsa04940	0.68841685
67	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.67139567
68	Peroxisome_Homo sapiens_hsa04146	0.66267001
69	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65898157
70	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.65875883
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65726790
72	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.64218582
73	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.64094087
74	Pyrimidine metabolism_Homo sapiens_hsa00240	0.63318421
75	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.62379980
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.61582905
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60866557
78	Serotonergic synapse_Homo sapiens_hsa04726	0.60652910
79	Huntingtons disease_Homo sapiens_hsa05016	0.58946270
80	Pyruvate metabolism_Homo sapiens_hsa00620	0.58929246
81	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.55560742
82	Primary immunodeficiency_Homo sapiens_hsa05340	0.54228610
83	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.52058530
84	Taste transduction_Homo sapiens_hsa04742	0.48609282
85	p53 signaling pathway_Homo sapiens_hsa04115	0.48393096
86	Protein export_Homo sapiens_hsa03060	0.47498733
87	Metabolic pathways_Homo sapiens_hsa01100	0.47324143
88	Oxidative phosphorylation_Homo sapiens_hsa00190	0.46479248
89	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46111317
90	Insulin secretion_Homo sapiens_hsa04911	0.45753721
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44754599
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44200727
93	Tryptophan metabolism_Homo sapiens_hsa00380	0.40355078
94	Renin secretion_Homo sapiens_hsa04924	0.39427001
95	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.39073544
96	Proteasome_Homo sapiens_hsa03050	0.38753513
97	Gap junction_Homo sapiens_hsa04540	0.36109100
98	Lysosome_Homo sapiens_hsa04142	0.34820981
99	Fatty acid degradation_Homo sapiens_hsa00071	0.31704195
100	Melanoma_Homo sapiens_hsa05218	0.30086448

RNF212B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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