RNF215

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.91890091
2synapsis (GO:0007129)8.30703255
3synaptonemal complex assembly (GO:0007130)8.21495052
4chromosome organization involved in meiosis (GO:0070192)7.63344588
5synaptonemal complex organization (GO:0070193)7.37455906
6male meiosis I (GO:0007141)7.30614184
7DNA methylation involved in gamete generation (GO:0043046)7.22019024
8male meiosis (GO:0007140)6.42719648
9positive regulation of male gonad development (GO:2000020)5.96395722
10meiosis I (GO:0007127)5.66426459
11regulation of meiosis I (GO:0060631)5.24654905
12meiotic nuclear division (GO:0007126)4.91059324
13regulation of male gonad development (GO:2000018)4.86323088
14meiotic chromosome segregation (GO:0045132)4.60021546
15meiotic cell cycle process (GO:1903046)4.40974723
16alanine transport (GO:0032328)4.29097670
17DNA synthesis involved in DNA repair (GO:0000731)4.28614004
18cellular response to ATP (GO:0071318)4.26343565
19sex differentiation (GO:0007548)4.25368549
20diaphragm development (GO:0060539)4.24301666
21parturition (GO:0007567)4.13107871
22seminiferous tubule development (GO:0072520)4.10104262
23positive regulation of meiosis (GO:0045836)4.08701565
24skeletal muscle organ development (GO:0060538)4.05065636
25cellular response to gonadotropin stimulus (GO:0071371)4.03034716
26embryonic foregut morphogenesis (GO:0048617)3.97296882
27gonadal mesoderm development (GO:0007506)3.95860850
28L-serine transport (GO:0015825)3.92543329
29reciprocal DNA recombination (GO:0035825)3.92480752
30reciprocal meiotic recombination (GO:0007131)3.92480752
31behavioral response to nicotine (GO:0035095)3.86914096
32metanephric mesenchyme development (GO:0072075)3.83561980
33positive regulation of meiotic cell cycle (GO:0051446)3.81667136
34regulation of female gonad development (GO:2000194)3.80896173
35sex determination (GO:0007530)3.75687379
36low-density lipoprotein particle remodeling (GO:0034374)3.74290389
37gene silencing by RNA (GO:0031047)3.68550908
38sodium ion export (GO:0071436)3.67756725
39negative regulation of metanephros development (GO:0072217)3.65662362
40regulation of glomerulus development (GO:0090192)3.65239814
41serine transport (GO:0032329)3.57148574
42kidney mesenchyme development (GO:0072074)3.55780652
43endocardial cushion development (GO:0003197)3.53173567
44base-excision repair, AP site formation (GO:0006285)3.52306257
45regulation of cell proliferation involved in kidney development (GO:1901722)3.51451185
46cellular potassium ion homeostasis (GO:0030007)3.49291200
47atrioventricular valve morphogenesis (GO:0003181)3.46198215
48C4-dicarboxylate transport (GO:0015740)3.42741804
49gamma-aminobutyric acid transport (GO:0015812)3.41059653
50muscle cell fate commitment (GO:0042693)3.39308782
51epithelial cell fate commitment (GO:0072148)3.37117913
52female gamete generation (GO:0007292)3.32494072
53resolution of meiotic recombination intermediates (GO:0000712)3.31238252
54L-amino acid import (GO:0043092)3.30139951
55lymphangiogenesis (GO:0001946)3.27857625
56amino acid import (GO:0043090)3.26875281
57mesonephros development (GO:0001823)3.23825999
58cellular sodium ion homeostasis (GO:0006883)3.20638067
59regulation of meiotic cell cycle (GO:0051445)3.20168423
60negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.18645593
61regulation of cardioblast differentiation (GO:0051890)3.17549739
62sister chromatid cohesion (GO:0007062)3.17189812
63cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.16390919
64outer ear morphogenesis (GO:0042473)3.07206399
65pyrimidine dimer repair (GO:0006290)3.06116621
66reproductive system development (GO:0061458)3.05837832
67response to gonadotropin (GO:0034698)3.05689618
68negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.04521094
69negative regulation of sodium ion transport (GO:0010766)3.04235992
70negative regulation of tissue remodeling (GO:0034104)3.02414228
71sulfur amino acid catabolic process (GO:0000098)3.00428925
72regulation of gene silencing by RNA (GO:0060966)2.98878984
73regulation of posttranscriptional gene silencing (GO:0060147)2.98878984
74regulation of gene silencing by miRNA (GO:0060964)2.98878984
75oxidative demethylation (GO:0070989)2.96334654
76histone H4-K12 acetylation (GO:0043983)2.92822432
77serine family amino acid catabolic process (GO:0009071)2.92445114
78G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.91247657
79endoderm formation (GO:0001706)2.90915873
80regulation of meiosis (GO:0040020)2.89509087
81regulation of cholesterol esterification (GO:0010872)2.88970057
82pharyngeal system development (GO:0060037)2.88064428
83auditory behavior (GO:0031223)2.84129476
84chondroitin sulfate catabolic process (GO:0030207)2.82730735
85fusion of sperm to egg plasma membrane (GO:0007342)2.80548781
86cell communication by electrical coupling (GO:0010644)2.79860143
87potassium ion import (GO:0010107)2.74774310
88DNA alkylation (GO:0006305)2.71906898
89DNA methylation (GO:0006306)2.71906898
90meiotic cell cycle (GO:0051321)2.65170454
91peptidyl-glutamic acid carboxylation (GO:0017187)2.62667707
92protein carboxylation (GO:0018214)2.62667707
93RNA localization (GO:0006403)2.62369377
94cardiac right ventricle morphogenesis (GO:0003215)2.61876087
95positive regulation of mesonephros development (GO:0061213)2.61603927
96cornea development in camera-type eye (GO:0061303)2.59930428
97mesenchymal to epithelial transition (GO:0060231)2.59117136
98locomotory exploration behavior (GO:0035641)2.58007330
99regulation of phospholipid biosynthetic process (GO:0071071)2.55060918
100endothelium development (GO:0003158)2.53378999
101spermatid development (GO:0007286)2.53305947
102positive regulation of fatty acid biosynthetic process (GO:0045723)2.53079097
103glycerophospholipid catabolic process (GO:0046475)2.52119862
104regulation of DNA endoreduplication (GO:0032875)2.51825523
105blood vessel maturation (GO:0001955)2.50915763
106proline transport (GO:0015824)2.50194167
107potassium ion homeostasis (GO:0055075)2.49174890
108atrial septum morphogenesis (GO:0060413)2.48651767
109cell migration involved in gastrulation (GO:0042074)2.48188465
110positive regulation of extracellular matrix organization (GO:1903055)2.48133901
111cellular response to cholesterol (GO:0071397)2.47792419
112neuromuscular process controlling posture (GO:0050884)2.47179688
113positive regulation of triglyceride biosynthetic process (GO:0010867)2.46952035
114regulation of skeletal muscle contraction (GO:0014819)2.45188485
115oogenesis (GO:0048477)2.44857110
116nucleotide transmembrane transport (GO:1901679)2.44292635
117sodium-independent organic anion transport (GO:0043252)2.44215080
118regulation of mesenchymal cell apoptotic process (GO:2001053)2.43706394
119dicarboxylic acid biosynthetic process (GO:0043650)2.43692335
120embryonic body morphogenesis (GO:0010172)2.43366084
121surfactant homeostasis (GO:0043129)2.43233190
122regulation of beta-amyloid formation (GO:1902003)2.42999473
123cardiac muscle hypertrophy in response to stress (GO:0014898)2.42841171
124muscle hypertrophy in response to stress (GO:0003299)2.42841171
125cardiac muscle adaptation (GO:0014887)2.42841171
126germ cell development (GO:0007281)2.41892262
127ubiquinone biosynthetic process (GO:0006744)2.40644486
128metanephric epithelium development (GO:0072207)2.40391040
129response to auditory stimulus (GO:0010996)2.40161443
130negative regulation of kidney development (GO:0090185)2.38462139
131L-serine metabolic process (GO:0006563)2.37876702
132positive regulation of heart growth (GO:0060421)2.37014329
133metanephros development (GO:0001656)2.36743630
134cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.36526768
135glycine metabolic process (GO:0006544)2.36394828
136dermatan sulfate metabolic process (GO:0030205)2.35985724
137glomerular basement membrane development (GO:0032836)2.35036074
138layer formation in cerebral cortex (GO:0021819)2.32079370
139heart valve formation (GO:0003188)2.27725960
140dermatan sulfate biosynthetic process (GO:0030208)2.26102273
141regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.23496941
142cGMP-mediated signaling (GO:0019934)2.23281941
143neurotransmitter-gated ion channel clustering (GO:0072578)2.22894204
144dendrite morphogenesis (GO:0048813)2.22414629
145regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.22201788
146regulation of vasculogenesis (GO:2001212)2.21520052
147pyrimidine nucleobase catabolic process (GO:0006208)2.19755475
148alpha-linolenic acid metabolic process (GO:0036109)2.19611200
149sodium ion homeostasis (GO:0055078)2.19149747
150synaptic vesicle maturation (GO:0016188)2.16244390
151regulation of synapse structural plasticity (GO:0051823)2.15546250
152acidic amino acid transport (GO:0015800)2.13874656
153neurotransmitter uptake (GO:0001504)2.10526301
154semaphorin-plexin signaling pathway (GO:0071526)2.09721339
155vascular endothelial growth factor signaling pathway (GO:0038084)2.08838216
156regulation of extracellular matrix organization (GO:1903053)2.08754426
157regulation of cholesterol biosynthetic process (GO:0045540)2.08252361
158glial cell proliferation (GO:0014009)2.07678829
159cellular response to sterol (GO:0036315)2.06926408
160negative regulation of astrocyte differentiation (GO:0048712)2.06803060
161nucleobase catabolic process (GO:0046113)2.06510621
162nerve growth factor signaling pathway (GO:0038180)2.06008919
163negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.05308570
164plasma lipoprotein particle remodeling (GO:0034369)2.04440798
165protein-lipid complex remodeling (GO:0034368)2.04440798
166macromolecular complex remodeling (GO:0034367)2.04440798
167regulation of amyloid precursor protein catabolic process (GO:1902991)2.03504565
168triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.03146887
169coronary vasculature morphogenesis (GO:0060977)2.03002429
170positive regulation of steroid metabolic process (GO:0045940)2.01705222
171positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.00618427
172positive regulation of cellular amide metabolic process (GO:0034250)2.00445259
173neutral amino acid transport (GO:0015804)2.00032090
174cytoskeletal anchoring at plasma membrane (GO:0007016)1.98342510
175plasma lipoprotein particle organization (GO:0071827)1.97867759
176positive regulation of synaptic transmission, dopaminergic (GO:0032226)1.96884424
177L-amino acid transport (GO:0015807)1.96725291
178activation of protein kinase A activity (GO:0034199)1.95807158
179protein-lipid complex subunit organization (GO:0071825)1.94680905
180endothelial cell differentiation (GO:0045446)1.94406777
181reverse cholesterol transport (GO:0043691)1.94334549
182regulation of short-term neuronal synaptic plasticity (GO:0048172)1.94169957
183positive regulation of potassium ion transmembrane transporter activity (GO:1901018)1.94017700
184response to cholesterol (GO:0070723)1.92968665
185regulation of triglyceride biosynthetic process (GO:0010866)1.92671557
186central nervous system myelination (GO:0022010)1.91437101
187axon ensheathment in central nervous system (GO:0032291)1.91437101
188positive regulation of membrane protein ectodomain proteolysis (GO:0051044)1.91361193
189anatomical structure maturation (GO:0071695)1.89774344
190negative regulation of synaptic transmission, GABAergic (GO:0032229)1.88890011
191positive regulation of lipid biosynthetic process (GO:0046889)1.88094898
192positive regulation of alcohol biosynthetic process (GO:1902932)1.87870448
193cellular modified amino acid catabolic process (GO:0042219)1.87509904
194regulation of astrocyte differentiation (GO:0048710)1.86815166
195neuromuscular process controlling balance (GO:0050885)1.86806951
196renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)1.86435835
197positive regulation of astrocyte differentiation (GO:0048711)1.86033464
198glutamate metabolic process (GO:0006536)1.85986237
199vocalization behavior (GO:0071625)1.85453420
200regulation of extracellular matrix disassembly (GO:0010715)1.85236983

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.15475286
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.11692853
3IGF1R_20145208_ChIP-Seq_DFB_Human2.68973912
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60066044
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.57571872
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.33039413
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.29632613
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28787324
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25769024
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25769024
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.24004799
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.21983139
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20604546
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.20243439
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15088801
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14848482
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11692619
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06388898
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00351852
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99234681
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.98103223
22YY1_22570637_ChIP-Seq_MALME-3M_Human1.96599028
23EZH2_22144423_ChIP-Seq_EOC_Human1.91109414
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89653495
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88825299
26P68_20966046_ChIP-Seq_HELA_Human1.88773996
27RNF2_27304074_Chip-Seq_NSC_Mouse1.88688500
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88406317
29CLOCK_20551151_ChIP-Seq_293T_Human1.86171799
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.81659882
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76822814
32ERA_21632823_ChIP-Seq_H3396_Human1.76549220
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76201044
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74505392
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.73732029
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.72234246
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66034870
38DROSHA_22980978_ChIP-Seq_HELA_Human1.63293653
39AR_21572438_ChIP-Seq_LNCaP_Human1.63093587
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.62604304
41PHF8_20622854_ChIP-Seq_HELA_Human1.62481818
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.62285962
43E2F1_20622854_ChIP-Seq_HELA_Human1.60937022
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.60303819
45IRF1_19129219_ChIP-ChIP_H3396_Human1.57454372
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53618833
47* LXR_22292898_ChIP-Seq_THP-1_Human1.49637741
48KDM2B_26808549_Chip-Seq_K562_Human1.49583851
49BCL6_27268052_Chip-Seq_Bcells_Human1.48957332
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43499430
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42729974
52CTCF_20526341_ChIP-Seq_ESCs_Human1.40530016
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40374035
54* TET1_21451524_ChIP-Seq_MESCs_Mouse1.40202185
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39878382
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39178039
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38913132
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.37529552
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37391647
60RXR_22158963_ChIP-Seq_LIVER_Mouse1.34793871
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.34100398
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33822750
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33668934
64TP53_22573176_ChIP-Seq_HFKS_Human1.30606692
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28287343
66SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.28170091
67LXR_22158963_ChIP-Seq_LIVER_Mouse1.26687927
68SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25380709
69* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.25261589
70BCOR_27268052_Chip-Seq_Bcells_Human1.25074470
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24035025
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20802979
73OCT4_19829295_ChIP-Seq_ESCs_Human1.20049050
74SOX2_21211035_ChIP-Seq_LN229_Human1.18765479
75* RARA_24833708_ChIP-Seq_LIVER_Mouse1.18454116
76SMC4_20622854_ChIP-Seq_HELA_Human1.18304459
77KDM2B_26808549_Chip-Seq_DND41_Human1.17770958
78OCT4_20526341_ChIP-Seq_ESCs_Human1.17186118
79TP53_16413492_ChIP-PET_HCT116_Human1.16662762
80TP53_18474530_ChIP-ChIP_U2OS_Human1.16471016
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15480286
82RARB_27405468_Chip-Seq_BRAIN_Mouse1.14917033
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13792633
84FOXP1_21924763_ChIP-Seq_HESCs_Human1.13342807
85* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12784136
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.12320338
87TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12142693
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.12049913
89KDM2B_26808549_Chip-Seq_JURKAT_Human1.11666223
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11242471
91ZNF274_21170338_ChIP-Seq_K562_Hela1.10435074
92E2F1_17053090_ChIP-ChIP_MCF-7_Human1.09773675
93PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09650949
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.08427081
95CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08390458
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.08225351
97RUNX_20019798_ChIP-Seq_JUKART_Human1.07539262
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07401546
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06876369
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06540831
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06439245
102SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06155670
103EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06081048
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05556684
105TP53_20018659_ChIP-ChIP_R1E_Mouse1.05243234
106RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04342084
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04338801
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04207235
109REST_21632747_ChIP-Seq_MESCs_Mouse1.03381966
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01840841
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01480449
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01351270
113TAF2_19829295_ChIP-Seq_ESCs_Human1.01273948
114NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.00945184
115CTCF_21964334_Chip-Seq_Bcells_Human1.00891153
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00620458
117EP300_21415370_ChIP-Seq_HL-1_Mouse1.00476902
118BCAT_22108803_ChIP-Seq_LS180_Human1.00382464
119ELK3_25401928_ChIP-Seq_HUVEC_Human0.99847765
120P53_21459846_ChIP-Seq_SAOS-2_Human0.99783794
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99690398
122LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99410995
123TET1_21490601_ChIP-Seq_MESCs_Mouse0.99361958
124* RARB_24833708_ChIP-Seq_LIVER_Mouse0.99066172
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99003893
126GABP_19822575_ChIP-Seq_HepG2_Human0.98461442
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98181418
128ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98034715
129VDR_24787735_ChIP-Seq_THP-1_Human0.97572514
130RAC3_21632823_ChIP-Seq_H3396_Human0.97501205
131GBX2_23144817_ChIP-Seq_PC3_Human0.97220266
132STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97101016
133TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96144758
134CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95471724
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95217938
136GATA1_19941826_ChIP-Seq_K562_Human0.95078362
137NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94489682
138KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93714878
139RXR_22108803_ChIP-Seq_LS180_Human0.93534778
140STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.93130351
141P300_27268052_Chip-Seq_Bcells_Human0.93012209
142TP53_22127205_ChIP-Seq_IMR90_Human0.92585784
143EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92581825
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.92175044
145MYC_19829295_ChIP-Seq_ESCs_Human0.91989254
146EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91544608
147TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90968368
148* FLI1_21867929_ChIP-Seq_CD8_Mouse0.90075419
149GATA1_26923725_Chip-Seq_HPCs_Mouse0.89392139
150SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89327536
151NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89021363
152TBX20_22328084_ChIP-Seq_HEART_Mouse0.88929099
153TBX20_22080862_ChIP-Seq_HEART_Mouse0.88929099
154NCOR_22424771_ChIP-Seq_293T_Human0.88599951
155* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87609304
156HOXB7_26014856_ChIP-Seq_BT474_Human0.87515705
157RACK7_27058665_Chip-Seq_MCF-7_Human0.87410861
158RING1B_27294783_Chip-Seq_NPCs_Mouse0.87178892
159P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86923720
160REST_18959480_ChIP-ChIP_MESCs_Mouse0.86043414
161ZNF263_19887448_ChIP-Seq_K562_Human0.85686952
162FOXO3_23340844_ChIP-Seq_DLD1_Human0.85411743
163NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84105035
164* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83315025
165CTCF_27219007_Chip-Seq_Bcells_Human0.82651917
166* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82297165
167TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81861043
168TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.81745093
169NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81649920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.41930933
2MP0002160_abnormal_reproductive_system3.56899534
3MP0005167_abnormal_blood-brain_barrier3.35438109
4MP0006292_abnormal_olfactory_placode3.15467291
5MP0003329_amyloid_beta_deposits3.09291504
6MP0009384_cardiac_valve_regurgitation2.73929930
7MP0009840_abnormal_foam_cell2.73522211
8MP0001661_extended_life_span2.72828779
9MP0003690_abnormal_glial_cell2.69730937
10MP0003646_muscle_fatigue2.69194217
11MP0002210_abnormal_sex_determination2.68543353
12MP0002254_reproductive_system_inflammat2.63714133
13MP0001986_abnormal_taste_sensitivity2.62984074
14MP0005389_reproductive_system_phenotype2.57750044
15MP0008995_early_reproductive_senescence2.47882848
16MP0004885_abnormal_endolymph2.47545119
17MP0000678_abnormal_parathyroid_gland2.36073685
18MP0004859_abnormal_synaptic_plasticity2.27814180
19MP0003191_abnormal_cellular_cholesterol2.21530663
20MP0001145_abnormal_male_reproductive2.21137302
21MP0003279_aneurysm2.19817137
22MP0001929_abnormal_gametogenesis2.16115469
23MP0000604_amyloidosis2.13443673
24MP0010386_abnormal_urinary_bladder2.07186236
25MP0003635_abnormal_synaptic_transmissio2.00978710
26MP0004858_abnormal_nervous_system1.98513214
27MP0000653_abnormal_sex_gland1.96317461
28MP0000013_abnormal_adipose_tissue1.92743687
29MP0003075_altered_response_to1.92088563
30MP0003698_abnormal_male_reproductive1.91968576
31MP0002837_dystrophic_cardiac_calcinosis1.89679470
32MP0003300_gastrointestinal_ulcer1.89398835
33MP0005423_abnormal_somatic_nervous1.89336357
34MP0010368_abnormal_lymphatic_system1.88280167
35MP0001958_emphysema1.88026403
36MP0005646_abnormal_pituitary_gland1.87397876
37MP0005410_abnormal_fertilization1.82217619
38MP0003705_abnormal_hypodermis_morpholog1.78114030
39MP0003633_abnormal_nervous_system1.77995509
40MP0008789_abnormal_olfactory_epithelium1.73275095
41MP0000049_abnormal_middle_ear1.67423766
42MP0009053_abnormal_anal_canal1.66870199
43MP0002249_abnormal_larynx_morphology1.66061458
44MP0001879_abnormal_lymphatic_vessel1.65783920
45MP0003119_abnormal_digestive_system1.61257755
46MP0002638_abnormal_pupillary_reflex1.59849378
47MP0010030_abnormal_orbit_morphology1.58995915
48MP0002735_abnormal_chemical_nociception1.57084388
49MP0000537_abnormal_urethra_morphology1.54271856
50MP0002909_abnormal_adrenal_gland1.53566820
51MP0003634_abnormal_glial_cell1.46721104
52MP0005645_abnormal_hypothalamus_physiol1.46377762
53MP0001919_abnormal_reproductive_system1.46362572
54MP0009780_abnormal_chondrocyte_physiolo1.44488541
55MP0002653_abnormal_ependyma_morphology1.43478952
56MP0005394_taste/olfaction_phenotype1.43474162
57MP0005499_abnormal_olfactory_system1.43474162
58MP0002064_seizures1.42212930
59MP0005174_abnormal_tail_pigmentation1.41193990
60MP0003942_abnormal_urinary_system1.39215857
61MP0003303_peritoneal_inflammation1.38232990
62MP0005360_urolithiasis1.38131220
63MP0001764_abnormal_homeostasis1.31443052
64MP0000465_gastrointestinal_hemorrhage1.30875572
65MP0003136_yellow_coat_color1.30526130
66MP0001486_abnormal_startle_reflex1.29701505
67MP0009745_abnormal_behavioral_response1.28159600
68MP0004130_abnormal_muscle_cell1.27944406
69MP0002139_abnormal_hepatobiliary_system1.27848356
70MP0005058_abnormal_lysosome_morphology1.27714388
71MP0002295_abnormal_pulmonary_circulatio1.27389263
72MP0005166_decreased_susceptibility_to1.26748908
73MP0004270_analgesia1.25664345
74MP0005551_abnormal_eye_electrophysiolog1.23810218
75MP0001119_abnormal_female_reproductive1.23104202
76MP0000538_abnormal_urinary_bladder1.23000616
77MP0003693_abnormal_embryo_hatching1.22372466
78MP0004272_abnormal_basement_membrane1.21866340
79MP0008569_lethality_at_weaning1.21421560
80MP0008058_abnormal_DNA_repair1.21235557
81MP0008438_abnormal_cutaneous_collagen1.20986015
82MP0001502_abnormal_circadian_rhythm1.20943629
83MP0006054_spinal_hemorrhage1.20803670
84MP0000778_abnormal_nervous_system1.20573474
85MP0000751_myopathy1.19294623
86MP0000920_abnormal_myelination1.18020116
87MP0005085_abnormal_gallbladder_physiolo1.17406001
88MP0002733_abnormal_thermal_nociception1.14992967
89MP0003631_nervous_system_phenotype1.14516070
90MP0009250_abnormal_appendicular_skeleto1.14475473
91MP0002063_abnormal_learning/memory/cond1.13695820
92MP0002161_abnormal_fertility/fecundity1.11977895
93MP0002089_abnormal_postnatal_growth/wei1.11158031
94MP0001440_abnormal_grooming_behavior1.06724565
95MP0003936_abnormal_reproductive_system1.05935227
96MP0005670_abnormal_white_adipose1.04799418
97MP0004133_heterotaxia1.03936206
98MP0000003_abnormal_adipose_tissue1.03222908
99MP0003183_abnormal_peptide_metabolism1.02792525
100MP0000767_abnormal_smooth_muscle1.01186445
101MP0005332_abnormal_amino_acid1.00833228
102MP0002572_abnormal_emotion/affect_behav0.98996952
103MP0010329_abnormal_lipoprotein_level0.97382511
104MP0000631_abnormal_neuroendocrine_gland0.97305959
105MP0002736_abnormal_nociception_after0.97152260
106MP0010234_abnormal_vibrissa_follicle0.96352188
107MP0003638_abnormal_response/metabolism_0.96004414
108MP0005171_absent_coat_pigmentation0.94390602
109MP0003123_paternal_imprinting0.94112295
110MP0001968_abnormal_touch/_nociception0.93685888
111MP0003937_abnormal_limbs/digits/tail_de0.93317236
112MP0005623_abnormal_meninges_morphology0.92802791
113MP0005584_abnormal_enzyme/coenzyme_acti0.91098762
114MP0003091_abnormal_cell_migration0.90331963
115MP0005595_abnormal_vascular_smooth0.89057342
116MP0008961_abnormal_basal_metabolism0.89036104
117MP0008874_decreased_physiological_sensi0.88972522
118MP0002557_abnormal_social/conspecific_i0.88825945
119MP0005165_increased_susceptibility_to0.88003795
120MP0001963_abnormal_hearing_physiology0.86669188
121MP0003699_abnormal_female_reproductive0.85828163
122MP0003890_abnormal_embryonic-extraembry0.85226865
123MP0001970_abnormal_pain_threshold0.84142187
124MP0000685_abnormal_immune_system0.84033304
125MP0002118_abnormal_lipid_homeostasis0.83520850
126MP0002998_abnormal_bone_remodeling0.82144633
127MP0003115_abnormal_respiratory_system0.81180625
128MP0009046_muscle_twitch0.80966424
129MP0003880_abnormal_central_pattern0.80082697
130MP0003724_increased_susceptibility_to0.79899056
131MP0003566_abnormal_cell_adhesion0.79255105
132MP0003567_abnormal_fetal_cardiomyocyte0.78241234
133MP0000026_abnormal_inner_ear0.77574690
134MP0000249_abnormal_blood_vessel0.77122871
135MP0003045_fibrosis0.76700578
136MP0006138_congestive_heart_failure0.76640294
137MP0004215_abnormal_myocardial_fiber0.76496193
138MP0000230_abnormal_systemic_arterial0.75924045
139MP0002138_abnormal_hepatobiliary_system0.75500303
140MP0003879_abnormal_hair_cell0.75182822
141MP0006276_abnormal_autonomic_nervous0.74332116
142MP0001485_abnormal_pinna_reflex0.72416463
143MP0003938_abnormal_ear_development0.71135418
144MP0002272_abnormal_nervous_system0.70775777
145MP0002876_abnormal_thyroid_physiology0.69672111
146MP0005375_adipose_tissue_phenotype0.69503925
147MP0005365_abnormal_bile_salt0.68273155
148MP0004142_abnormal_muscle_tone0.67947713
149MP0004019_abnormal_vitamin_homeostasis0.66886299
150MP0003195_calcinosis0.66779368
151MP0000639_abnormal_adrenal_gland0.66414656
152MP0002067_abnormal_sensory_capabilities0.66053904
153MP0001501_abnormal_sleep_pattern0.65756147
154MP0001666_abnormal_nutrient_absorption0.65610021
155MP0008875_abnormal_xenobiotic_pharmacok0.65210616
156MP0001849_ear_inflammation0.64616926
157MP0005195_abnormal_posterior_eye0.64403905
158MP0005220_abnormal_exocrine_pancreas0.64304536
159MP0000534_abnormal_ureter_morphology0.63895963
160MP0009764_decreased_sensitivity_to0.63849923
161MP0001188_hyperpigmentation0.63810298
162MP0001348_abnormal_lacrimal_gland0.63485617
163MP0003172_abnormal_lysosome_physiology0.63003505
164MP0002168_other_aberrant_phenotype0.62125894
165MP0002734_abnormal_mechanical_nocicepti0.62078487
166MP0001873_stomach_inflammation0.61880906
167MP0002233_abnormal_nose_morphology0.61023136
168MP0003315_abnormal_perineum_morphology0.60880055
169MP0001299_abnormal_eye_distance/0.60698396
170MP0001270_distended_abdomen0.60524143
171MP0003786_premature_aging0.59763876
172MP0000343_altered_response_to0.59299948
173MP0003718_maternal_effect0.59281179
174MP0000428_abnormal_craniofacial_morphol0.59012491

Predicted human phenotypes

RankGene SetZ-score
1Gonadal dysgenesis (HP:0000133)5.17780839
2Mesangial abnormality (HP:0001966)4.98885952
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.73571675
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.73571675
5Neurofibrillary tangles (HP:0002185)4.68417847
6Abnormality of the lower motor neuron (HP:0002366)4.62621190
7Hemiplegia (HP:0002301)4.18184685
8Back pain (HP:0003418)3.99005470
9Hemiparesis (HP:0001269)3.94563465
10Cerebral inclusion bodies (HP:0100314)3.92958608
11Abnormality of the corticospinal tract (HP:0002492)3.91738803
12Testicular neoplasm (HP:0010788)3.89273142
13Aplasia involving bones of the upper limbs (HP:0009823)3.81025277
14Aplasia of the phalanges of the hand (HP:0009802)3.81025277
15Aplasia involving bones of the extremities (HP:0009825)3.81025277
16Anomalous pulmonary venous return (HP:0010772)3.79638053
17Megalencephaly (HP:0001355)3.65449596
18Supranuclear gaze palsy (HP:0000605)3.60450484
19Testicular atrophy (HP:0000029)3.56339010
20Diplopia (HP:0000651)3.56071426
21Abnormality of binocular vision (HP:0011514)3.56071426
22Shoulder girdle muscle weakness (HP:0003547)3.53091673
23Osteomalacia (HP:0002749)3.47154730
24Upper motor neuron abnormality (HP:0002127)3.46415100
25Abnormality of the pulmonary veins (HP:0011718)3.40681494
26True hermaphroditism (HP:0010459)3.27198754
27Male infertility (HP:0003251)3.25521886
28Facial shape deformation (HP:0011334)3.20612903
29Potter facies (HP:0002009)3.20612903
30Amyloidosis (HP:0011034)3.11195506
31Bronchomalacia (HP:0002780)3.11058388
32Male pseudohermaphroditism (HP:0000037)3.08744908
33Hypoplastic heart (HP:0001961)3.01165459
34Increased cerebral lipofuscin (HP:0011813)2.94501202
35Abnormal ventriculo-arterial connection (HP:0011563)2.89633578
36Transposition of the great arteries (HP:0001669)2.89633578
37Abnormal connection of the cardiac segments (HP:0011545)2.89633578
38Abnormality of the renal collecting system (HP:0004742)2.88430810
39Broad metatarsal (HP:0001783)2.87145018
40Amyotrophic lateral sclerosis (HP:0007354)2.86589892
41Humeroradial synostosis (HP:0003041)2.83623393
42Synostosis involving the elbow (HP:0003938)2.83623393
43Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.79961215
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.78042042
45Turricephaly (HP:0000262)2.73671081
46Ectopic kidney (HP:0000086)2.72494209
47Preauricular pit (HP:0004467)2.70794835
48Periauricular skin pits (HP:0100277)2.70794835
49Cerebral aneurysm (HP:0004944)2.70191417
50Morphological abnormality of the middle ear (HP:0008609)2.65238656
51Abnormality of DNA repair (HP:0003254)2.64116302
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.63688710
53Chronic hepatic failure (HP:0100626)2.62009105
54Impaired vibration sensation in the lower limbs (HP:0002166)2.57116925
55Abnormality of cochlea (HP:0000375)2.50103734
56Clumsiness (HP:0002312)2.48862864
57Xanthomatosis (HP:0000991)2.48448478
58Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.46890878
59Short 1st metacarpal (HP:0010034)2.46890878
60Stenosis of the external auditory canal (HP:0000402)2.45797261
61Fatigue (HP:0012378)2.45557004
62Abnormal lung lobation (HP:0002101)2.45269222
63Abnormality of the vocal cords (HP:0008777)2.44485856
64Urinary bladder sphincter dysfunction (HP:0002839)2.40037265
65Rimmed vacuoles (HP:0003805)2.37755991
66Shallow orbits (HP:0000586)2.35255374
67Arterial tortuosity (HP:0005116)2.33593084
68Nephronophthisis (HP:0000090)2.30941088
69Female pseudohermaphroditism (HP:0010458)2.27304433
70Facial hemangioma (HP:0000329)2.25985355
71Attenuation of retinal blood vessels (HP:0007843)2.25576143
72Rib fusion (HP:0000902)2.25450941
73Polycythemia (HP:0001901)2.23874174
74Deep venous thrombosis (HP:0002625)2.23157569
75Aortic dissection (HP:0002647)2.23128939
76Interstitial pulmonary disease (HP:0006530)2.23036551
77Abnormal sex determination (HP:0012244)2.18997835
78Sex reversal (HP:0012245)2.18997835
79Retinal dysplasia (HP:0007973)2.18508146
80Carpal bone hypoplasia (HP:0001498)2.16904046
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16775228
82Abnormality of alanine metabolism (HP:0010916)2.16775228
83Hyperalaninemia (HP:0003348)2.16775228
84Gonadotropin excess (HP:0000837)2.16176127
85Rectovaginal fistula (HP:0000143)2.15920600
86Rectal fistula (HP:0100590)2.15920600
87Vaginal fistula (HP:0004320)2.15404524
88Vascular tortuosity (HP:0004948)2.12174372
89Hypoplastic left heart (HP:0004383)2.11521470
90Urinary urgency (HP:0000012)2.10853129
91Stage 5 chronic kidney disease (HP:0003774)2.08088699
92Hypoplasia of the uterus (HP:0000013)2.07950886
93Abnormality of the costochondral junction (HP:0000919)2.07492905
94Abnormality of the 1st metacarpal (HP:0010009)2.06864391
95Status epilepticus (HP:0002133)2.06685216
96Visceral angiomatosis (HP:0100761)2.06655359
97Visual hallucinations (HP:0002367)2.06516484
98Premature rupture of membranes (HP:0001788)2.01518110
99Hyperglycinemia (HP:0002154)1.99703091
100Dysostosis multiplex (HP:0000943)1.99666196
101Poikiloderma (HP:0001029)1.99661309
102Hyperlipoproteinemia (HP:0010980)1.98810430
103Small hand (HP:0200055)1.98799876
104Aortic aneurysm (HP:0004942)1.97229810
105Hand muscle atrophy (HP:0009130)1.96383145
106Neuronal loss in central nervous system (HP:0002529)1.96343215
107Germ cell neoplasia (HP:0100728)1.95614518
108Apathy (HP:0000741)1.95506748
109Preaxial foot polydactyly (HP:0001841)1.94360870
110Tachypnea (HP:0002789)1.94119797
111Hematochezia (HP:0002573)1.92791315
112Type II lissencephaly (HP:0007260)1.92294346
113Diminished motivation (HP:0000745)1.90937971
114Abnormality of glycolipid metabolism (HP:0010969)1.90248958
115Abnormality of liposaccharide metabolism (HP:0010968)1.90248958
116Abnormality of glycosphingolipid metabolism (HP:0004343)1.90248958
117Pendular nystagmus (HP:0012043)1.90105750
118Hemangiomatosis (HP:0007461)1.89882113
119Ketoacidosis (HP:0001993)1.87835720
120Morphological abnormality of the inner ear (HP:0011390)1.87716630
121Prolonged partial thromboplastin time (HP:0003645)1.87635456
122Dementia (HP:0000726)1.86379313
123Morphological abnormality of the pyramidal tract (HP:0002062)1.86366707
124Reduced antithrombin III activity (HP:0001976)1.85121288
125Truncal ataxia (HP:0002078)1.84467188
126Retinal atrophy (HP:0001105)1.83753917
127Disproportionate tall stature (HP:0001519)1.82733080
128Depression (HP:0000716)1.82106032
129Congenital stationary night blindness (HP:0007642)1.81469851
130Genetic anticipation (HP:0003743)1.81034023
131Lip pit (HP:0100267)1.81026149
132Mutism (HP:0002300)1.79733737
133Buphthalmos (HP:0000557)1.79499396
134Dyskinesia (HP:0100660)1.78758578
135Delayed epiphyseal ossification (HP:0002663)1.77465900
136Mitral regurgitation (HP:0001653)1.77203192
137Narrow nasal bridge (HP:0000446)1.76687890
138Azoospermia (HP:0000027)1.76478281
139Abnormality of the renal medulla (HP:0100957)1.75642289
140Squamous cell carcinoma (HP:0002860)1.75368324
141Bony spicule pigmentary retinopathy (HP:0007737)1.74813490
142Anteriorly placed anus (HP:0001545)1.73689349
143Infertility (HP:0000789)1.73570948
144Spastic gait (HP:0002064)1.71671185
145Action tremor (HP:0002345)1.70961942
146Abnormality of the aortic arch (HP:0012303)1.70690511
147Abnormality of midbrain morphology (HP:0002418)1.69528166
148Molar tooth sign on MRI (HP:0002419)1.69528166
149Abnormality of the Achilles tendon (HP:0005109)1.69304489
150Hypokalemic alkalosis (HP:0001949)1.68991637
151Rapidly progressive (HP:0003678)1.68637050
152Optic nerve coloboma (HP:0000588)1.68153454
153Intestinal fistula (HP:0100819)1.68078235
154Focal seizures (HP:0007359)1.67371679
155Pseudobulbar signs (HP:0002200)1.67322957
156Achilles tendon contracture (HP:0001771)1.67281239
157Abnormality of the proximal phalanges of the hand (HP:0009834)1.66543099
158Protrusio acetabuli (HP:0003179)1.65974421
159Widely patent fontanelles and sutures (HP:0004492)1.65864328
160Abnormality of the nasal septum (HP:0000419)1.65654333
161Polygenic inheritance (HP:0010982)1.65448486
162Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65079014
163Bowing of the arm (HP:0006488)1.64657876
164Bowed forearm bones (HP:0003956)1.64657876
165Ketosis (HP:0001946)1.64471884
166Mitral stenosis (HP:0001718)1.64023196
167Skin pits (HP:0100276)1.63861765
168Rigidity (HP:0002063)1.63785556
169Abnormality of the middle phalanges of the toes (HP:0010183)1.63736632
170Hypoventilation (HP:0002791)1.63418354
171Generalized hypotonia (HP:0001290)1.62984705
172Mitral valve prolapse (HP:0001634)1.62924668
173Coronal craniosynostosis (HP:0004440)1.62745380
174Atrophy/Degeneration involving motor neurons (HP:0007373)1.62412905
175Premature skin wrinkling (HP:0100678)1.62084343
176Biconcave vertebral bodies (HP:0004586)1.61922637
177Hypoalphalipoproteinemia (HP:0003233)1.61354365
178Congenital diaphragmatic hernia (HP:0000776)1.60809481
179Bulbar palsy (HP:0001283)1.60767223
180Neoplasm of the heart (HP:0100544)1.60461303
181Progressive neurologic deterioration (HP:0002344)1.59713944
182Short hallux (HP:0010109)1.59406192
183Mucopolysacchariduria (HP:0008155)1.59378245
184Urinary glycosaminoglycan excretion (HP:0003541)1.59378245
185Ankle clonus (HP:0011448)1.57916353
186Lymphangioma (HP:0100764)1.55085787
187Deviation of the hallux (HP:0010051)1.54795086
188Neonatal short-limb short stature (HP:0008921)1.54571923
189Vascular calcification (HP:0004934)1.54404833
190Complement deficiency (HP:0004431)1.54173436
191Esophageal varix (HP:0002040)1.52808205
192Abnormality of mucopolysaccharide metabolism (HP:0011020)1.52558371
193Abnormality of polysaccharide metabolism (HP:0011012)1.52558371
194Abnormality of glycosaminoglycan metabolism (HP:0004371)1.52558371
195Striae distensae (HP:0001065)1.51950202
196Protuberant abdomen (HP:0001538)1.51458856

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.80654074
2PNCK3.28094445
3TRIB33.03371041
4ZAK2.90800558
5MAP3K132.56993647
6TLK12.49572638
7EPHA42.46751658
8WNK42.41471526
9PINK12.11055946
10OXSR12.04572670
11NTRK22.03788382
12MET2.00775763
13NEK92.00701596
14MARK11.96121486
15MAP3K91.94685297
16EPHB11.92174801
17FGFR21.90955009
18PDK21.83247631
19GRK11.81360565
20SIK11.80511884
21PHKG21.79231235
22PHKG11.79231235
23TGFBR21.78452457
24ERN11.77652115
25TNIK1.76628891
26STK161.73713168
27AURKA1.68812363
28SIK21.60579233
29PKN21.59776556
30MAP3K41.58181524
31KSR21.56593178
32MAP2K21.54557013
33ADRBK21.51788031
34TIE11.50269085
35BMPR1B1.50198766
36KDR1.48141333
37PTK61.48101480
38LMTK21.47230554
39FGFR41.46575891
40PDGFRA1.45308429
41MAP2K71.44345893
42MAPK121.41569908
43RET1.41536263
44TNK21.40296097
45CAMK1G1.33867774
46MAP4K21.33177434
47RIPK11.30069501
48RPS6KA21.29844041
49DMPK1.28616985
50NTRK11.27939041
51DAPK21.26735277
52FGFR31.25287051
53BLK1.21772838
54SGK4941.21515026
55SGK2231.21515026
56STK391.20022902
57FES1.17725101
58FRK1.15938103
59PLK11.13601991
60EPHB21.12449945
61TTN1.12161935
62CAMK1D1.11239631
63RPS6KA61.09062770
64CASK1.05950792
65MAP2K41.05499514
66STK38L1.04189922
67CDK41.03632897
68DYRK20.97886749
69MARK20.96342470
70TYRO30.95832013
71NTRK30.95126515
72PRKCH0.94916267
73PAK30.92715768
74DDR20.91839724
75BRAF0.91494505
76LRRK20.89956158
77PLK40.89941738
78RPS6KL10.86956054
79RPS6KC10.86956054
80SGK10.86860771
81EEF2K0.85839433
82GRK60.83108478
83MAP3K10.82948979
84JAK20.81126983
85MAP4K10.80578007
86PRKD10.80033659
87NEK20.79528459
88GRK70.79417669
89CDK50.79198578
90JAK10.79054722
91ATR0.77783455
92ADRBK10.75918834
93PRKCI0.75773718
94MOS0.75678630
95MAPK130.74504608
96FER0.74316315
97BMX0.73396280
98SGK20.72891226
99PAK60.71126579
100SCYL20.70192082
101MAP3K70.70173169
102MYLK0.70050187
103PTK20.69947196
104PRKD20.69394030
105MINK10.69242371
106ROCK10.68652816
107UHMK10.67548840
108STK110.67158572
109RPS6KA10.65649592
110RPS6KB10.65506811
111ROCK20.65338821
112MAPK40.64201540
113PKN10.62974543
114ARAF0.62867071
115ITK0.61529095
116PRKCG0.61471334
117RPS6KA50.61355558
118BCKDK0.61283401
119HCK0.60620374
120MUSK0.59694354
121PRKD30.58673639
122FGFR10.58566971
123MAPK110.57196450
124RIPK40.56845186
125INSRR0.55943729
126TBK10.55941973
127CAMKK10.55938906
128MAPK150.55768235
129PDGFRB0.55481423
130CSNK1G10.54226838
131ACVR1B0.54120429
132DYRK1A0.53049527
133MAP3K110.53003910
134MAP3K20.51628932
135MAP3K100.51508031
136FGR0.51318156
137MAP2K10.51303381
138FYN0.50707019
139PTK2B0.50552253
140EIF2AK30.50480293
141MAP2K60.49062030
142TYK20.48747744
143CSF1R0.48001363
144PDPK10.47379937
145PAK20.46449049
146TTK0.45254396
147STK380.44948613
148WNK10.44617019
149SRC0.43820560
150PRKACA0.43421470
151IGF1R0.42676372
152PRKCE0.42589080
153PRKCZ0.42097061
154CHEK20.41724279
155HIPK20.41368815
156CSNK1G20.38170932
157BRSK10.34886241
158CSNK1G30.33761589
159RPS6KA30.33153091
160ABL20.32942404
161STK30.31080671
162TGFBR10.27292660
163CDK80.27165627

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.08906443
2Sulfur relay system_Homo sapiens_hsa041223.90893776
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.82683927
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.87020170
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.66347828
6Fatty acid biosynthesis_Homo sapiens_hsa000612.15664172
7Base excision repair_Homo sapiens_hsa034102.08146702
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.06237671
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77223869
10Selenocompound metabolism_Homo sapiens_hsa004501.75491359
11Fatty acid degradation_Homo sapiens_hsa000711.63458367
12Linoleic acid metabolism_Homo sapiens_hsa005911.59139082
13Bile secretion_Homo sapiens_hsa049761.55989725
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51941645
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45859204
16Fatty acid metabolism_Homo sapiens_hsa012121.41096650
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36658741
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30576607
19Chemical carcinogenesis_Homo sapiens_hsa052041.29530764
20Regulation of autophagy_Homo sapiens_hsa041401.28689050
21Retinol metabolism_Homo sapiens_hsa008301.28357168
22Arginine and proline metabolism_Homo sapiens_hsa003301.26596707
23Hedgehog signaling pathway_Homo sapiens_hsa043401.25901700
24Gastric acid secretion_Homo sapiens_hsa049711.25884819
25GABAergic synapse_Homo sapiens_hsa047271.24928266
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23404762
27Fanconi anemia pathway_Homo sapiens_hsa034601.21151485
28Salivary secretion_Homo sapiens_hsa049701.21023348
29Renin secretion_Homo sapiens_hsa049241.19941551
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18207064
31Nicotine addiction_Homo sapiens_hsa050331.18032460
32PPAR signaling pathway_Homo sapiens_hsa033201.17885655
33Sulfur metabolism_Homo sapiens_hsa009201.17849472
34Homologous recombination_Homo sapiens_hsa034401.15747062
35Glutamatergic synapse_Homo sapiens_hsa047241.13942208
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11460366
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10973100
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10447727
39Basal transcription factors_Homo sapiens_hsa030221.10161829
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08156634
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06898103
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.04953176
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.01716619
44Pancreatic secretion_Homo sapiens_hsa049720.99823446
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98860924
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98352138
47Lysosome_Homo sapiens_hsa041420.97588298
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97290942
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97148164
50Folate biosynthesis_Homo sapiens_hsa007900.96987346
51Phototransduction_Homo sapiens_hsa047440.96939508
52Basal cell carcinoma_Homo sapiens_hsa052170.96610569
53Arginine biosynthesis_Homo sapiens_hsa002200.95826481
54Insulin secretion_Homo sapiens_hsa049110.95056531
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94799085
56One carbon pool by folate_Homo sapiens_hsa006700.94276208
57Nucleotide excision repair_Homo sapiens_hsa034200.93557235
58Taste transduction_Homo sapiens_hsa047420.93410556
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92368539
60Morphine addiction_Homo sapiens_hsa050320.89627203
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89570322
62Dorso-ventral axis formation_Homo sapiens_hsa043200.88774449
63Pyruvate metabolism_Homo sapiens_hsa006200.88365596
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88300626
65Axon guidance_Homo sapiens_hsa043600.88194964
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.87674203
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87402954
68Cocaine addiction_Homo sapiens_hsa050300.87264873
69Vitamin B6 metabolism_Homo sapiens_hsa007500.87186566
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.84727515
71TGF-beta signaling pathway_Homo sapiens_hsa043500.84657085
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84535994
73Sphingolipid metabolism_Homo sapiens_hsa006000.84420917
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.83701353
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83467882
76Butanoate metabolism_Homo sapiens_hsa006500.83155287
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82548929
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81960230
79cAMP signaling pathway_Homo sapiens_hsa040240.81446332
80Ovarian steroidogenesis_Homo sapiens_hsa049130.80024643
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79255545
82Complement and coagulation cascades_Homo sapiens_hsa046100.78444687
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78079518
84Oocyte meiosis_Homo sapiens_hsa041140.77817383
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.77026217
86Dilated cardiomyopathy_Homo sapiens_hsa054140.76952694
87Vitamin digestion and absorption_Homo sapiens_hsa049770.76639010
88Circadian entrainment_Homo sapiens_hsa047130.75497591
89Prion diseases_Homo sapiens_hsa050200.73489895
90Propanoate metabolism_Homo sapiens_hsa006400.73302674
91Mismatch repair_Homo sapiens_hsa034300.73196470
92DNA replication_Homo sapiens_hsa030300.72659969
93Fatty acid elongation_Homo sapiens_hsa000620.72640162
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72598955
95ECM-receptor interaction_Homo sapiens_hsa045120.72357967
96Tryptophan metabolism_Homo sapiens_hsa003800.71295319
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71227675
98Protein digestion and absorption_Homo sapiens_hsa049740.70599338
99Other glycan degradation_Homo sapiens_hsa005110.70452152
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69882417
101Renal cell carcinoma_Homo sapiens_hsa052110.69869204
102Steroid biosynthesis_Homo sapiens_hsa001000.69755043
103Long-term potentiation_Homo sapiens_hsa047200.69424771
104B cell receptor signaling pathway_Homo sapiens_hsa046620.69137754
105Rap1 signaling pathway_Homo sapiens_hsa040150.68607208
106Focal adhesion_Homo sapiens_hsa045100.67961688
107Estrogen signaling pathway_Homo sapiens_hsa049150.65878500
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65583282
109Lysine degradation_Homo sapiens_hsa003100.65015488
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64565073
111Malaria_Homo sapiens_hsa051440.64358872
112Ether lipid metabolism_Homo sapiens_hsa005650.64059680
113GnRH signaling pathway_Homo sapiens_hsa049120.63602509
114Melanogenesis_Homo sapiens_hsa049160.63039847
115Gap junction_Homo sapiens_hsa045400.62878946
116Cholinergic synapse_Homo sapiens_hsa047250.62756837
117VEGF signaling pathway_Homo sapiens_hsa043700.62314683
118Olfactory transduction_Homo sapiens_hsa047400.61993818
119Type II diabetes mellitus_Homo sapiens_hsa049300.60793421
120N-Glycan biosynthesis_Homo sapiens_hsa005100.60656593
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.59720504
122Calcium signaling pathway_Homo sapiens_hsa040200.59492270
123Osteoclast differentiation_Homo sapiens_hsa043800.59286664
124RNA degradation_Homo sapiens_hsa030180.58915900
125Metabolic pathways_Homo sapiens_hsa011000.58648891
126RNA polymerase_Homo sapiens_hsa030200.58589745
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57857131
128p53 signaling pathway_Homo sapiens_hsa041150.57835940
129Insulin resistance_Homo sapiens_hsa049310.57751644
130Glioma_Homo sapiens_hsa052140.57688665
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.57289084
132Pancreatic cancer_Homo sapiens_hsa052120.56424450
133Peroxisome_Homo sapiens_hsa041460.56372946
134mTOR signaling pathway_Homo sapiens_hsa041500.56288452
135RNA transport_Homo sapiens_hsa030130.56022709
136ABC transporters_Homo sapiens_hsa020100.55947808
137Choline metabolism in cancer_Homo sapiens_hsa052310.55732685
138Long-term depression_Homo sapiens_hsa047300.55439097
139Proteoglycans in cancer_Homo sapiens_hsa052050.54889499
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54285156
141beta-Alanine metabolism_Homo sapiens_hsa004100.54192227
142Arachidonic acid metabolism_Homo sapiens_hsa005900.54151909
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.53865638
144Oxytocin signaling pathway_Homo sapiens_hsa049210.53759067
145Staphylococcus aureus infection_Homo sapiens_hsa051500.53554623
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.53364290
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53301330
148Synaptic vesicle cycle_Homo sapiens_hsa047210.52988060
149Dopaminergic synapse_Homo sapiens_hsa047280.51212954
150Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51140308
151Vascular smooth muscle contraction_Homo sapiens_hsa042700.50658923
152Amoebiasis_Homo sapiens_hsa051460.49710318
153Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49449108
154Endocytosis_Homo sapiens_hsa041440.49299199
155Thyroid hormone synthesis_Homo sapiens_hsa049180.49057719
156Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48926634
157Drug metabolism - other enzymes_Homo sapiens_hsa009830.48421186
158Pyrimidine metabolism_Homo sapiens_hsa002400.48309042
159ErbB signaling pathway_Homo sapiens_hsa040120.47558685
160Hippo signaling pathway_Homo sapiens_hsa043900.47427996
161Glutathione metabolism_Homo sapiens_hsa004800.46919312
162Leukocyte transendothelial migration_Homo sapiens_hsa046700.46916033
163Platelet activation_Homo sapiens_hsa046110.46649588
164Bladder cancer_Homo sapiens_hsa052190.44941453
165Galactose metabolism_Homo sapiens_hsa000520.42307452
166Cell cycle_Homo sapiens_hsa041100.40246887
167Serotonergic synapse_Homo sapiens_hsa047260.38137004
168Histidine metabolism_Homo sapiens_hsa003400.38078954

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