RNF222

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1molting cycle (GO:0042303)8.94330430
2hair cycle (GO:0042633)8.94330430
3desmosome organization (GO:0002934)5.55077126
4keratinization (GO:0031424)5.34193699
5omega-hydroxylase P450 pathway (GO:0097267)4.33546525
6response to pheromone (GO:0019236)4.19698741
7behavioral response to nicotine (GO:0035095)4.17324538
8L-fucose catabolic process (GO:0042355)4.15209654
9fucose catabolic process (GO:0019317)4.15209654
10L-fucose metabolic process (GO:0042354)4.15209654
11facial nerve structural organization (GO:0021612)4.06525267
12platelet dense granule organization (GO:0060155)4.03420042
13keratinocyte development (GO:0003334)4.01198047
14superoxide anion generation (GO:0042554)3.93796725
15establishment of skin barrier (GO:0061436)3.93385416
16piRNA metabolic process (GO:0034587)3.75778832
17protein heterotetramerization (GO:0051290)3.68410391
18detection of light stimulus involved in sensory perception (GO:0050962)3.68402884
19detection of light stimulus involved in visual perception (GO:0050908)3.68402884
20presynaptic membrane assembly (GO:0097105)3.67898159
21amino sugar catabolic process (GO:0046348)3.67501517
22ribosomal small subunit assembly (GO:0000028)3.66568828
23cellular ketone body metabolic process (GO:0046950)3.65639606
24water-soluble vitamin biosynthetic process (GO:0042364)3.64366730
25cranial nerve morphogenesis (GO:0021602)3.60890825
26kynurenine metabolic process (GO:0070189)3.53740017
27bundle of His cell to Purkinje myocyte communication (GO:0086069)3.53474239
28tryptophan catabolic process (GO:0006569)3.51260257
29indole-containing compound catabolic process (GO:0042436)3.51260257
30indolalkylamine catabolic process (GO:0046218)3.51260257
31detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.50857890
32detection of bacterium (GO:0016045)3.45113338
33ketone body metabolic process (GO:1902224)3.36609270
34detection of other organism (GO:0098543)3.33307295
35response to peptidoglycan (GO:0032494)3.31512447
36intermediate filament organization (GO:0045109)3.30031902
37keratinocyte differentiation (GO:0030216)3.25146226
38regulation of water loss via skin (GO:0033561)3.24047590
39preassembly of GPI anchor in ER membrane (GO:0016254)3.22256338
40respiratory chain complex IV assembly (GO:0008535)3.19738670
41positive regulation of monocyte chemotaxis (GO:0090026)3.11993478
42regulation of T-helper 1 cell differentiation (GO:0045625)3.11938303
43phospholipid scrambling (GO:0017121)3.11823427
44indolalkylamine metabolic process (GO:0006586)3.10858450
45negative regulation of T-helper cell differentiation (GO:0045623)3.09459776
46negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.09459776
47proteasome assembly (GO:0043248)3.08579783
48regulation of male gonad development (GO:2000018)3.08238781
49cranial nerve structural organization (GO:0021604)3.08003133
50regulation of nuclear cell cycle DNA replication (GO:0033262)3.07493288
51protein complex biogenesis (GO:0070271)3.05181280
52G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.04975536
53neutrophil activation (GO:0042119)3.04485341
54neutrophil activation involved in immune response (GO:0002283)3.03660663
55tryptophan metabolic process (GO:0006568)3.03082194
56DNA methylation involved in gamete generation (GO:0043046)3.02590217
57viral transcription (GO:0019083)3.02183114
58mitochondrial respiratory chain complex I assembly (GO:0032981)3.01739382
59NADH dehydrogenase complex assembly (GO:0010257)3.01739382
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01739382
61membrane invagination (GO:0010324)3.00637583
62mannosylation (GO:0097502)2.99847891
63negative regulation of keratinocyte proliferation (GO:0010839)2.98748664
64sphingoid metabolic process (GO:0046519)2.95580380
65granulocyte activation (GO:0036230)2.94690916
66auditory receptor cell stereocilium organization (GO:0060088)2.94613831
67presynaptic membrane organization (GO:0097090)2.94047590
68response to muramyl dipeptide (GO:0032495)2.93804335
69primary amino compound metabolic process (GO:1901160)2.92960306
70phosphatidylinositol acyl-chain remodeling (GO:0036149)2.91854173
71neuronal action potential (GO:0019228)2.91166321
72nonmotile primary cilium assembly (GO:0035058)2.89677894
73negative regulation of telomere maintenance (GO:0032205)2.88199102
74regulation of action potential (GO:0098900)2.87702796
75adenosine metabolic process (GO:0046085)2.87026741
76protein K11-linked deubiquitination (GO:0035871)2.86442512
77opioid receptor signaling pathway (GO:0038003)2.86161441
78regulation of activation of Janus kinase activity (GO:0010533)2.85272309
79inositol phosphate catabolic process (GO:0071545)2.83598236
80glycerophospholipid catabolic process (GO:0046475)2.83587471
81epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83394044
82glucosamine-containing compound catabolic process (GO:1901072)2.81125653
83axoneme assembly (GO:0035082)2.81112203
84translational termination (GO:0006415)2.80645977
85gamma-aminobutyric acid transport (GO:0015812)2.80289745
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79778174
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79778174
88negative regulation of leukocyte chemotaxis (GO:0002689)2.79125356
89neural crest cell development (GO:0014032)2.79120850
90mesonephros development (GO:0001823)2.77486957
91amine catabolic process (GO:0009310)2.76734241
92cellular biogenic amine catabolic process (GO:0042402)2.76734241
93inner ear receptor stereocilium organization (GO:0060122)2.76297186
94replication fork processing (GO:0031297)2.74721480
95GPI anchor metabolic process (GO:0006505)2.73840060
96dopamine transport (GO:0015872)2.73281205
97adaptation of signaling pathway (GO:0023058)2.72901810
98positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.72895743
99mitochondrial respiratory chain complex assembly (GO:0033108)2.72700548
100protein-cofactor linkage (GO:0018065)2.72059985
101photoreceptor cell maintenance (GO:0045494)2.71861922
102regulation of ruffle assembly (GO:1900027)2.71023781
103ribosomal small subunit biogenesis (GO:0042274)2.70837949
104cytochrome complex assembly (GO:0017004)2.69915553
105mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65219228
106S-adenosylmethionine metabolic process (GO:0046500)2.64779749
107cilium morphogenesis (GO:0060271)2.64283684
108mammary gland epithelial cell differentiation (GO:0060644)2.64105138
109indole-containing compound metabolic process (GO:0042430)2.63851494
110negative regulation of DNA-dependent DNA replication (GO:2000104)2.63757517
111regulation of interleukin-8 secretion (GO:2000482)2.63562733
112regulation of interleukin-6 biosynthetic process (GO:0045408)2.62654678
113negative regulation of interleukin-1 beta production (GO:0032691)2.62544856
114ribosomal large subunit biogenesis (GO:0042273)2.62323717
115peptide cross-linking (GO:0018149)2.62089412
116phosphorylated carbohydrate dephosphorylation (GO:0046838)2.61297879
117inositol phosphate dephosphorylation (GO:0046855)2.61297879
118lipoxygenase pathway (GO:0019372)2.60917745
119negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.60850895
120regulation of glucokinase activity (GO:0033131)2.59745685
121regulation of hexokinase activity (GO:1903299)2.59745685
122regulation of rhodopsin mediated signaling pathway (GO:0022400)2.59287685
123L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59089722
124behavioral response to ethanol (GO:0048149)2.57283178
125positive regulation of cellular amide metabolic process (GO:0034250)2.56957645
126photoreceptor cell development (GO:0042461)2.56751797
127positive regulation of action potential (GO:0045760)2.56409728
128dendritic cell chemotaxis (GO:0002407)2.55370089
129positive regulation of T cell migration (GO:2000406)2.54761373
130phosphatidylserine acyl-chain remodeling (GO:0036150)2.54596015
131epithelial cilium movement (GO:0003351)2.54309046
132rhodopsin mediated signaling pathway (GO:0016056)2.53480779
133SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.53145150
134reciprocal meiotic recombination (GO:0007131)2.51549179
135reciprocal DNA recombination (GO:0035825)2.51549179
136cornea development in camera-type eye (GO:0061303)2.51237787
137C-terminal protein amino acid modification (GO:0018410)2.50721837
138negative regulation of viral genome replication (GO:0045071)2.50568882
139epidermis development (GO:0008544)2.49891701
140response to nitrosative stress (GO:0051409)2.49464958
141cellular response to exogenous dsRNA (GO:0071360)2.49300353
142DNA double-strand break processing (GO:0000729)2.48854583
143phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.48225264
144cytidine deamination (GO:0009972)2.48167070
145cytidine metabolic process (GO:0046087)2.48167070
146cytidine catabolic process (GO:0006216)2.48167070
147positive regulation of male gonad development (GO:2000020)2.48123830
148response to folic acid (GO:0051593)2.46916504
149respiratory burst (GO:0045730)2.46831792
150cotranslational protein targeting to membrane (GO:0006613)2.46749318
151regulation of cilium movement (GO:0003352)2.46733574
152spinal cord motor neuron differentiation (GO:0021522)2.46693232
153protein targeting to ER (GO:0045047)2.46595190
154pyrimidine nucleobase catabolic process (GO:0006208)2.46588583
155cilium or flagellum-dependent cell motility (GO:0001539)2.46583689
156regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.45938613
157negative regulation of mast cell activation (GO:0033004)2.45881970
158cilium organization (GO:0044782)2.45844384
159nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.45287520
160sensory perception of smell (GO:0007608)2.44264298
161purinergic nucleotide receptor signaling pathway (GO:0035590)2.43745898
162protein localization to cilium (GO:0061512)2.43427683
163regulation of T-helper 2 cell differentiation (GO:0045628)2.43123268
164exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.42977515
165establishment of protein localization to mitochondrial membrane (GO:0090151)2.42926130
166polyol catabolic process (GO:0046174)2.41557305
167positive regulation of prostaglandin secretion (GO:0032308)2.41362111
168nucleoside diphosphate catabolic process (GO:0009134)2.40849480
169kidney morphogenesis (GO:0060993)2.40285203
170postsynaptic membrane organization (GO:0001941)2.39008914
171positive regulation of lymphocyte migration (GO:2000403)2.38533562
172thyroid gland development (GO:0030878)2.37511576
173lymphoid progenitor cell differentiation (GO:0002320)2.35132152
174response to hyperoxia (GO:0055093)2.32729253
175response to increased oxygen levels (GO:0036296)2.32729253
176mesenchymal cell development (GO:0014031)2.32610273
177establishment of protein localization to endoplasmic reticulum (GO:0072599)2.32537836
178protein localization to endoplasmic reticulum (GO:0070972)2.32445694
179sympathetic nervous system development (GO:0048485)2.32366959
180negative regulation of alpha-beta T cell differentiation (GO:0046639)2.32161751
181regulation of granulocyte chemotaxis (GO:0071622)2.32077336
182DNA ligation (GO:0006266)2.29704607
183regulation of monocyte chemotaxis (GO:0090025)2.29135298
184mesenchymal cell differentiation involved in renal system development (GO:2001012)2.29056490
185mesenchymal cell differentiation involved in kidney development (GO:0072161)2.29056490
186DNA deamination (GO:0045006)2.27103511
187dendritic cell migration (GO:0036336)2.27073158
188tRNA methylation (GO:0030488)2.26260411
189positive regulation of T-helper 1 type immune response (GO:0002827)2.26118337
190regulation of somitogenesis (GO:0014807)2.25896253
191regulation of apoptotic process involved in morphogenesis (GO:1902337)2.25730091
192leukocyte aggregation (GO:0070486)2.25080183
193regulation of neutrophil chemotaxis (GO:0090022)2.24804178
194regulation of neutrophil migration (GO:1902622)2.24804178
195epidermal cell differentiation (GO:0009913)2.24629553
196regulation of timing of cell differentiation (GO:0048505)2.23772066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.16267860
2ZNF274_21170338_ChIP-Seq_K562_Hela3.79036956
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.74350963
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80155852
5EZH2_22144423_ChIP-Seq_EOC_Human2.76288440
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.64001981
7IGF1R_20145208_ChIP-Seq_DFB_Human2.61491777
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.49431635
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45611978
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45509702
11FUS_26573619_Chip-Seq_HEK293_Human2.37422226
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31978610
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31539869
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.30956837
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.30136749
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23206864
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.21687294
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.20352039
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18331610
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.17147058
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12662720
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07918401
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05269138
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04325585
25EWS_26573619_Chip-Seq_HEK293_Human2.04241312
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.91594113
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.91589969
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.88132262
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.84280478
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.84264776
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.82971724
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80793119
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79343767
34ER_23166858_ChIP-Seq_MCF-7_Human1.79340874
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79010289
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.77428015
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.74333296
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73589174
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72243442
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67425348
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.65516867
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.65316550
43TP53_22573176_ChIP-Seq_HFKS_Human1.65030830
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63464018
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.62017138
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60903817
47AR_25329375_ChIP-Seq_VCAP_Human1.60314246
48BCAT_22108803_ChIP-Seq_LS180_Human1.59343331
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58092955
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.57129241
51CDX2_20551321_ChIP-Seq_CACO-2_Human1.55121577
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53720312
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52084065
54NMYC_18555785_Chip-Seq_ESCs_Mouse1.49350361
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.49048819
56SUZ12_18555785_Chip-Seq_ESCs_Mouse1.47447153
57P63_26484246_Chip-Seq_KERATINOCYTES_Human1.47303973
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46617665
59TAF15_26573619_Chip-Seq_HEK293_Human1.46257071
60MYC_18940864_ChIP-ChIP_HL60_Human1.46003140
61P53_22387025_ChIP-Seq_ESCs_Mouse1.44950479
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.44555324
63IRF1_19129219_ChIP-ChIP_H3396_Human1.44182585
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43883856
65IRF8_27001747_Chip-Seq_BMDM_Mouse1.43578868
66SMAD4_21799915_ChIP-Seq_A2780_Human1.42841709
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42827041
68CBP_20019798_ChIP-Seq_JUKART_Human1.42571545
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42571545
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42347174
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42152471
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41973449
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.41086206
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40645096
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.40645096
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.40612159
77RUNX1_27457419_Chip-Seq_LIVER_Mouse1.40073179
78STAT3_23295773_ChIP-Seq_U87_Human1.39042774
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38914099
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.38450700
81SOX2_19829295_ChIP-Seq_ESCs_Human1.38297670
82NANOG_19829295_ChIP-Seq_ESCs_Human1.38297670
83RNF2_27304074_Chip-Seq_NSC_Mouse1.36196854
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35947940
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.33598129
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33596473
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32556748
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.32401137
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31723683
90P300_18555785_Chip-Seq_ESCs_Mouse1.30423398
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.30034435
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.28256787
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28036064
94STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27041861
95TP53_18474530_ChIP-ChIP_U2OS_Human1.26490886
96NCOR_22424771_ChIP-Seq_293T_Human1.25957508
97TCF4_23295773_ChIP-Seq_U87_Human1.25668957
98TCF4_22108803_ChIP-Seq_LS180_Human1.25310758
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.25234932
100SOX2_18555785_Chip-Seq_ESCs_Mouse1.25164663
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24590629
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.24308360
103ZFX_18555785_Chip-Seq_ESCs_Mouse1.24226437
104PU1_27457419_Chip-Seq_LIVER_Mouse1.24160313
105OCT4_18555785_Chip-Seq_ESCs_Mouse1.24084684
106GBX2_23144817_ChIP-Seq_PC3_Human1.24056605
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23758277
108* AR_20517297_ChIP-Seq_VCAP_Human1.23564344
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23041206
110RUNX2_22187159_ChIP-Seq_PCA_Human1.22061406
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.21394735
112REST_21632747_ChIP-Seq_MESCs_Mouse1.19936110
113SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19673755
114VDR_23849224_ChIP-Seq_CD4+_Human1.19302851
115JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19153408
116ESRRB_18555785_Chip-Seq_ESCs_Mouse1.19044883
117* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19025252
118VDR_22108803_ChIP-Seq_LS180_Human1.18714509
119GATA3_21878914_ChIP-Seq_MCF-7_Human1.17550089
120EGR1_19032775_ChIP-ChIP_M12_Human1.17460457
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17438812
122SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17024906
123CTCF_18555785_Chip-Seq_ESCs_Mouse1.16901587
124SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16636641
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.16383294
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15708979
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15708979
128BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15701171
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15191329
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.15081322
131ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14256291
132SCL_19346495_ChIP-Seq_HPC-7_Human1.14173351
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14066930
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13535620
135SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12582870
136NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12136786
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12068745
138ELK1_19687146_ChIP-ChIP_HELA_Human1.12024782
139FLI1_21867929_ChIP-Seq_TH2_Mouse1.10936925
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10707010
141RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10209153
142KLF4_18555785_Chip-Seq_ESCs_Mouse1.09745299
143PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08443627
144AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07872290
145SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07613694
146PIAS1_25552417_ChIP-Seq_VCAP_Human1.06526101
147P300_19829295_ChIP-Seq_ESCs_Human1.06070367
148CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05263112
149SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04860206
150SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04860206
151HTT_18923047_ChIP-ChIP_STHdh_Human1.04735111
152EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04016214
153CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03185842
154SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03037209
155OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03024935
156SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02258976
157EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01567940
158RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01567940
159TAL1_26923725_Chip-Seq_HPCs_Mouse1.01433617
160* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01057906
161RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00764124
162EZH2_27294783_Chip-Seq_ESCs_Mouse0.99657915
163HOXB7_26014856_ChIP-Seq_BT474_Human0.98658168
164STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98538393
165SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98003982
166* GATA3_21867929_ChIP-Seq_TH1_Mouse0.98003333
167IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96574067
168VDR_24787735_ChIP-Seq_THP-1_Human0.95404909
169KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93832368
170OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93606899
171GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93227332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.29106572
2MP0004381_abnormal_hair_follicle4.26596590
3MP0009379_abnormal_foot_pigmentation3.77864628
4MP0001188_hyperpigmentation3.59294222
5MP0002009_preneoplasia3.43378469
6MP0002796_impaired_skin_barrier3.41105328
7MP0000579_abnormal_nail_morphology3.22554032
8MP0003195_calcinosis3.09714711
9MP0003941_abnormal_skin_development2.96384707
10MP0008877_abnormal_DNA_methylation2.80842873
11MP0005409_darkened_coat_color2.74490050
12MP0002102_abnormal_ear_morphology2.73758070
13MP0002098_abnormal_vibrissa_morphology2.70208408
14MP0001968_abnormal_touch/_nociception2.62130437
15MP0008260_abnormal_autophagy2.57783782
16MP0000569_abnormal_digit_pigmentation2.56510419
17MP0000647_abnormal_sebaceous_gland2.56455490
18MP0006072_abnormal_retinal_apoptosis2.55607227
19MP0005551_abnormal_eye_electrophysiolog2.52440174
20MP0005451_abnormal_body_composition2.46948146
21MP0004885_abnormal_endolymph2.45388613
22MP0000372_irregular_coat_pigmentation2.44560811
23MP0006292_abnormal_olfactory_placode2.42089024
24MP0001984_abnormal_olfaction2.41751306
25MP0008875_abnormal_xenobiotic_pharmacok2.24834233
26MP0005275_abnormal_skin_tensile2.19107127
27MP0002736_abnormal_nociception_after2.16543003
28MP0005501_abnormal_skin_physiology2.12266253
29MP0005253_abnormal_eye_physiology2.12218192
30MP0002837_dystrophic_cardiac_calcinosis2.08158491
31MP0003724_increased_susceptibility_to2.00134953
32MP0008872_abnormal_physiological_respon1.97013940
33MP0002938_white_spotting1.96439062
34MP0003787_abnormal_imprinting1.95883016
35MP0002277_abnormal_respiratory_mucosa1.95333170
36MP0002148_abnormal_hypersensitivity_rea1.93919791
37MP0003880_abnormal_central_pattern1.88851685
38MP0009745_abnormal_behavioral_response1.87252742
39MP0000566_synostosis1.86136269
40MP0009046_muscle_twitch1.83600945
41MP0010234_abnormal_vibrissa_follicle1.81710054
42MP0001835_abnormal_antigen_presentation1.79107483
43MP0009785_altered_susceptibility_to1.78985895
44MP0001501_abnormal_sleep_pattern1.78082476
45MP0005646_abnormal_pituitary_gland1.77781655
46MP0002095_abnormal_skin_pigmentation1.74142812
47MP0004142_abnormal_muscle_tone1.71978761
48MP0002132_abnormal_respiratory_system1.70747823
49MP0004510_myositis1.69411002
50MP0005174_abnormal_tail_pigmentation1.68720781
51MP0001346_abnormal_lacrimal_gland1.67413523
52MP0005171_absent_coat_pigmentation1.65451060
53MP0000383_abnormal_hair_follicle1.62485076
54MP0002876_abnormal_thyroid_physiology1.62052077
55MP0000377_abnormal_hair_follicle1.60236487
56MP0002272_abnormal_nervous_system1.58929758
57MP0004147_increased_porphyrin_level1.58422526
58MP0003453_abnormal_keratinocyte_physiol1.58007518
59MP0002254_reproductive_system_inflammat1.57756481
60MP0002249_abnormal_larynx_morphology1.57238328
61MP0004043_abnormal_pH_regulation1.56714828
62MP0001216_abnormal_epidermal_layer1.54003533
63MP0010386_abnormal_urinary_bladder1.49825948
64MP0002234_abnormal_pharynx_morphology1.47880553
65MP0000015_abnormal_ear_pigmentation1.46649289
66MP0002653_abnormal_ependyma_morphology1.46562202
67MP0002166_altered_tumor_susceptibility1.43217516
68MP0005084_abnormal_gallbladder_morpholo1.42443809
69MP0005671_abnormal_response_to1.41622685
70MP0002006_tumorigenesis1.41247478
71MP0005377_hearing/vestibular/ear_phenot1.40627641
72MP0003878_abnormal_ear_physiology1.40627641
73MP0001486_abnormal_startle_reflex1.40225567
74MP0002735_abnormal_chemical_nociception1.39787234
75MP0001529_abnormal_vocalization1.39704006
76MP0000427_abnormal_hair_cycle1.38877383
77MP0005000_abnormal_immune_tolerance1.38300192
78MP0000681_abnormal_thyroid_gland1.33099546
79MP0003436_decreased_susceptibility_to1.31941393
80MP0001986_abnormal_taste_sensitivity1.30965287
81MP0010678_abnormal_skin_adnexa1.29100050
82MP0004742_abnormal_vestibular_system1.28792993
83MP0002557_abnormal_social/conspecific_i1.27525405
84MP0001485_abnormal_pinna_reflex1.26448365
85MP0002060_abnormal_skin_morphology1.25020957
86MP0010771_integument_phenotype1.24148668
87MP0005085_abnormal_gallbladder_physiolo1.23317739
88MP0002928_abnormal_bile_duct1.22984406
89MP0003763_abnormal_thymus_physiology1.22834728
90MP0004782_abnormal_surfactant_physiolog1.21938686
91MP0005025_abnormal_response_to1.21602246
92MP0001764_abnormal_homeostasis1.20269782
93MP0000762_abnormal_tongue_morphology1.20267049
94MP0001970_abnormal_pain_threshold1.19882717
95MP0002638_abnormal_pupillary_reflex1.19692505
96MP0002138_abnormal_hepatobiliary_system1.19461270
97MP0000538_abnormal_urinary_bladder1.19249621
98MP0004133_heterotaxia1.18982853
99MP0000631_abnormal_neuroendocrine_gland1.18519001
100MP0002751_abnormal_autonomic_nervous1.18266899
101MP0002419_abnormal_innate_immunity1.18058245
102MP0002909_abnormal_adrenal_gland1.15702390
103MP0002067_abnormal_sensory_capabilities1.12238064
104MP0003011_delayed_dark_adaptation1.10617284
105MP0003718_maternal_effect1.09538478
106MP0004924_abnormal_behavior1.08626364
107MP0005386_behavior/neurological_phenoty1.08626364
108MP0002572_abnormal_emotion/affect_behav1.08308399
109MP0001905_abnormal_dopamine_level1.07495152
110MP0003283_abnormal_digestive_organ1.06989051
111MP0008995_early_reproductive_senescence1.06656884
112MP0003315_abnormal_perineum_morphology1.04832816
113MP0002177_abnormal_outer_ear1.03709079
114MP0004947_skin_inflammation1.03621924
115MP0001853_heart_inflammation1.03080380
116MP0005075_abnormal_melanosome_morpholog1.02146091
117MP0005410_abnormal_fertilization1.01661500
118MP0000049_abnormal_middle_ear1.01097310
119MP0000367_abnormal_coat/_hair1.00393285
120MP0001919_abnormal_reproductive_system0.99503300
121MP0002064_seizures0.98291404
122MP0008058_abnormal_DNA_repair0.98128820
123MP0005332_abnormal_amino_acid0.97380044
124MP0002733_abnormal_thermal_nociception0.97139366
125MP0002452_abnormal_antigen_presenting0.97134621
126MP0002723_abnormal_immune_serum0.97125331
127MP0003646_muscle_fatigue0.96707613
128MP0001800_abnormal_humoral_immune0.96466846
129MP0002282_abnormal_trachea_morphology0.95131413
130MP0003786_premature_aging0.93712318
131MP0004215_abnormal_myocardial_fiber0.92451670
132MP0000465_gastrointestinal_hemorrhage0.92319792
133MP0009697_abnormal_copulation0.92084601
134MP0005367_renal/urinary_system_phenotyp0.90558099
135MP0000516_abnormal_urinary_system0.90558099
136MP0006276_abnormal_autonomic_nervous0.90469515
137MP0004145_abnormal_muscle_electrophysio0.89320467
138MP0006036_abnormal_mitochondrial_physio0.89317498
139MP0001819_abnormal_immune_cell0.88395104
140MP0002163_abnormal_gland_morphology0.88137920
141MP0002420_abnormal_adaptive_immunity0.87725467
142MP0005195_abnormal_posterior_eye0.86867555
143MP0009764_decreased_sensitivity_to0.86528571
144MP0005379_endocrine/exocrine_gland_phen0.85602531
145MP0002693_abnormal_pancreas_physiology0.84618068
146MP0005464_abnormal_platelet_physiology0.83041164
147MP0006082_CNS_inflammation0.82473108
148MP0000613_abnormal_salivary_gland0.82369388
149MP0003252_abnormal_bile_duct0.80793338
150MP0000467_abnormal_esophagus_morphology0.80755495
151MP0001944_abnormal_pancreas_morphology0.79768453
152MP0001502_abnormal_circadian_rhythm0.79688061
153MP0003698_abnormal_male_reproductive0.79569055
154MP0008789_abnormal_olfactory_epithelium0.78688490
155MP0002734_abnormal_mechanical_nocicepti0.78466272
156MP0001929_abnormal_gametogenesis0.78197495
157MP0009931_abnormal_skin_appearance0.77783482
158MP0003303_peritoneal_inflammation0.77181485
159MP0005645_abnormal_hypothalamus_physiol0.76342170
160MP0002160_abnormal_reproductive_system0.73602567
161MP0005387_immune_system_phenotype0.71608555
162MP0001790_abnormal_immune_system0.71608555
163MP0000490_abnormal_crypts_of0.71182191
164MP0001191_abnormal_skin_condition0.70451512
165MP0001542_abnormal_bone_strength0.67505737
166MP0000678_abnormal_parathyroid_gland0.66289559
167MP0005165_increased_susceptibility_to0.65562415
168MP0005389_reproductive_system_phenotype0.65400086
169MP0005310_abnormal_salivary_gland0.64557354
170MP0000685_abnormal_immune_system0.64325736
171MP0010155_abnormal_intestine_physiology0.60969724
172MP0009333_abnormal_splenocyte_physiolog0.60024369
173MP0000026_abnormal_inner_ear0.59803570

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)6.00624319
2Woolly hair (HP:0002224)5.10101802
3Parakeratosis (HP:0001036)4.28581492
4Congenital stationary night blindness (HP:0007642)4.14521740
5Increased IgE level (HP:0003212)4.09405724
6Molar tooth sign on MRI (HP:0002419)4.06908062
7Abnormality of midbrain morphology (HP:0002418)4.06908062
8Abnormality of the axillary hair (HP:0100134)4.01567393
9Abnormality of secondary sexual hair (HP:0009888)4.01567393
10Slow-growing hair (HP:0002217)3.79690554
11Abnormality of hair growth rate (HP:0011363)3.79690554
12Pancreatic cysts (HP:0001737)3.76437092
13Pancreatic fibrosis (HP:0100732)3.55141845
14Nephronophthisis (HP:0000090)3.49358483
15Dry hair (HP:0011359)3.47002446
16Recurrent bacterial skin infections (HP:0005406)3.39791834
17Eczematoid dermatitis (HP:0000976)3.37492076
18Type II lissencephaly (HP:0007260)3.35644287
19Recurrent abscess formation (HP:0002722)3.30567584
20Sparse eyelashes (HP:0000653)3.21720408
21Onycholysis (HP:0001806)3.16079673
22Medial flaring of the eyebrow (HP:0010747)3.12183860
23Abnormality of nail color (HP:0100643)3.12009529
24Congenital ichthyosiform erythroderma (HP:0007431)3.08144800
25Amelogenesis imperfecta (HP:0000705)3.04775515
26Erythema (HP:0010783)3.03981020
27Attenuation of retinal blood vessels (HP:0007843)3.03276387
28Abolished electroretinogram (ERG) (HP:0000550)3.03274553
29Palmoplantar hyperkeratosis (HP:0000972)3.02942367
30Thick nail (HP:0001805)3.01899073
31Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.00775744
32Abnormality of the renal medulla (HP:0100957)3.00447935
33Abnormality of the renal cortex (HP:0011035)2.99043723
34Pili torti (HP:0003777)2.96861350
35Sex reversal (HP:0012245)2.92160306
36Abnormal sex determination (HP:0012244)2.92160306
37Palmar hyperkeratosis (HP:0010765)2.91705131
38Fragile nails (HP:0001808)2.91047873
39Congenital, generalized hypertrichosis (HP:0004540)2.88696065
40Nonprogressive disorder (HP:0003680)2.88559563
41Plantar hyperkeratosis (HP:0007556)2.88457229
42Cerebellar dysplasia (HP:0007033)2.87522540
43Chronic obstructive pulmonary disease (HP:0006510)2.79885667
44Obstructive lung disease (HP:0006536)2.79885667
45Pendular nystagmus (HP:0012043)2.78927292
46Mediastinal lymphadenopathy (HP:0100721)2.74993932
47Brittle hair (HP:0002299)2.71037185
48Decreased electroretinogram (ERG) amplitude (HP:0000654)2.66787450
49Type I transferrin isoform profile (HP:0003642)2.65524050
50Reticulocytopenia (HP:0001896)2.62808468
51Hypoplasia of the pons (HP:0012110)2.60034227
52Abnormal rod and cone electroretinograms (HP:0008323)2.58982861
53Hyperventilation (HP:0002883)2.54817982
54Pruritus (HP:0000989)2.53823373
55Abnormality of the pons (HP:0007361)2.53724709
56Chronic hepatic failure (HP:0100626)2.53251857
57Tubular atrophy (HP:0000092)2.52561745
58Abnormal drinking behavior (HP:0030082)2.48379450
59Polydipsia (HP:0001959)2.48379450
60Concave nail (HP:0001598)2.47921802
61Nail dystrophy (HP:0008404)2.47107621
62Acute necrotizing encephalopathy (HP:0006965)2.46756326
63Abnormality of alanine metabolism (HP:0010916)2.44352648
64Hyperalaninemia (HP:0003348)2.44352648
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.44352648
66Stomatitis (HP:0010280)2.44338794
67Recurrent skin infections (HP:0001581)2.43192957
68Increased CSF lactate (HP:0002490)2.42842687
69Mitochondrial inheritance (HP:0001427)2.40484147
70Gaze-evoked nystagmus (HP:0000640)2.38782357
71Lipid accumulation in hepatocytes (HP:0006561)2.37339444
72Progressive macrocephaly (HP:0004481)2.36129377
73Abnormal hair laboratory examination (HP:0003328)2.33116028
74Large for gestational age (HP:0001520)2.32465714
75Erythroderma (HP:0001019)2.31826964
76Reduced antithrombin III activity (HP:0001976)2.31298993
77True hermaphroditism (HP:0010459)2.30995766
78Hemiparesis (HP:0001269)2.27968905
79Conical tooth (HP:0000698)2.25712395
80Lip pit (HP:0100267)2.24717755
81Vacuolated lymphocytes (HP:0001922)2.23928442
82Nephrogenic diabetes insipidus (HP:0009806)2.23895222
83Methylmalonic acidemia (HP:0002912)2.23047694
84Aplasia cutis congenita (HP:0001057)2.22445931
85Renal cortical cysts (HP:0000803)2.22319238
86Natal tooth (HP:0000695)2.21567308
87Retinal dysplasia (HP:0007973)2.21049818
88Methylmalonic aciduria (HP:0012120)2.21037939
893-Methylglutaconic aciduria (HP:0003535)2.19923046
90Gait imbalance (HP:0002141)2.19386435
91Furrowed tongue (HP:0000221)2.19208102
92Acute encephalopathy (HP:0006846)2.18583382
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.18577644
94Abnormality of dental color (HP:0011073)2.18438462
95Decreased central vision (HP:0007663)2.17545785
96Aplasia/Hypoplasia of the tibia (HP:0005772)2.17478154
97Congenital primary aphakia (HP:0007707)2.17195049
98Sclerocornea (HP:0000647)2.16662653
99Cystic liver disease (HP:0006706)2.14567501
100Hypothermia (HP:0002045)2.12121201
101Recurrent cutaneous fungal infections (HP:0011370)2.10370564
102Chronic mucocutaneous candidiasis (HP:0002728)2.10370564
103Increased corneal curvature (HP:0100692)2.10247319
104Keratoconus (HP:0000563)2.10247319
105Chorioretinal atrophy (HP:0000533)2.08923283
106Ectropion (HP:0000656)2.07780875
107Ketoacidosis (HP:0001993)2.06689218
108Abnormality of the labia minora (HP:0012880)2.06636995
109Gangrene (HP:0100758)2.06425114
110Polyuria (HP:0000103)2.05363252
111Thyroiditis (HP:0100646)2.04096449
112Prostate neoplasm (HP:0100787)2.03383734
113Progressive inability to walk (HP:0002505)2.02754183
114Lissencephaly (HP:0001339)2.01218646
115Bony spicule pigmentary retinopathy (HP:0007737)2.01127795
116Right ventricular cardiomyopathy (HP:0011663)2.01120149
117Recurrent gram-negative bacterial infections (HP:0005420)2.00602348
118Anhidrosis (HP:0000970)1.99389243
119Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98758788
120Abnormal mitochondria in muscle tissue (HP:0008316)1.98278520
121Myositis (HP:0100614)1.97760608
122Abnormality of the preputium (HP:0100587)1.97434787
123Meningitis (HP:0001287)1.96522272
124Hyperglycinemia (HP:0002154)1.95643767
125Hyperglycinuria (HP:0003108)1.94868607
126Abnormality of macular pigmentation (HP:0008002)1.94573633
127Optic disc pallor (HP:0000543)1.94191918
128Abnormal biliary tract physiology (HP:0012439)1.94099373
129Bile duct proliferation (HP:0001408)1.94099373
130Clubbing of toes (HP:0100760)1.93912666
131Dynein arm defect of respiratory motile cilia (HP:0012255)1.93230943
132Absent/shortened dynein arms (HP:0200106)1.93230943
133Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93167719
134Corneal dystrophy (HP:0001131)1.92982194
135Inability to walk (HP:0002540)1.91595772
136Congenital hepatic fibrosis (HP:0002612)1.90413737
137Short tibia (HP:0005736)1.90247501
138Absent thumb (HP:0009777)1.88505591
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.88402027
140Hypoplasia of the fovea (HP:0007750)1.88166821
141Aplasia/Hypoplasia of the fovea (HP:0008060)1.88166821
142Arthropathy (HP:0003040)1.87275647
143Follicular hyperkeratosis (HP:0007502)1.86817560
144Retrobulbar optic neuritis (HP:0100654)1.86746138
145Optic neuritis (HP:0100653)1.86746138
146Stomach cancer (HP:0012126)1.86198553
147Abnormality of cells of the erythroid lineage (HP:0012130)1.86024059
148Genital tract atresia (HP:0001827)1.84997244
149Intestinal atresia (HP:0011100)1.84720947
150Renal Fanconi syndrome (HP:0001994)1.84655106
151Broad-based gait (HP:0002136)1.84637260
152Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84454622
153Prolonged bleeding time (HP:0003010)1.83666301
154Severe muscular hypotonia (HP:0006829)1.83636495
155Constricted visual fields (HP:0001133)1.83567057
156Febrile seizures (HP:0002373)1.82355475
157Basal ganglia calcification (HP:0002135)1.81544953
158Absent hair (HP:0002298)1.79922686
159Congenital sensorineural hearing impairment (HP:0008527)1.79327644
160Aplasia/hypoplasia of the uterus (HP:0008684)1.78374741
161Ketosis (HP:0001946)1.77427580
162Hypergammaglobulinemia (HP:0010702)1.77371056
163Corneal erosion (HP:0200020)1.75836627
164Absent eyebrow (HP:0002223)1.75777387
165Increased hepatocellular lipid droplets (HP:0006565)1.74359964
166Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72091238
167Abnormal protein N-linked glycosylation (HP:0012347)1.72091238
168Abnormal protein glycosylation (HP:0012346)1.72091238
169Abnormal glycosylation (HP:0012345)1.72091238
170Distal lower limb muscle weakness (HP:0009053)1.72083292
171Hypoalbuminemia (HP:0003073)1.71472617
172Abnormal albumin level (HP:0012116)1.71472617
173Abnormal respiratory epithelium morphology (HP:0012253)1.71133700
174Abnormal respiratory motile cilium morphology (HP:0005938)1.71133700
175Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70641727
176Alopecia of scalp (HP:0002293)1.70398421
177Vaginal atresia (HP:0000148)1.70244967
178Male pseudohermaphroditism (HP:0000037)1.70221694
179Ridged nail (HP:0001807)1.69364756
180Abnormality of serine family amino acid metabolism (HP:0010894)1.69221288
181Abnormality of glycine metabolism (HP:0010895)1.69221288
182Recurrent fungal infections (HP:0002841)1.68633625
183Abnormality of macrophages (HP:0004311)1.68166393
184Hypohidrosis (HP:0000966)1.67418466
185Abnormality of molar (HP:0011077)1.66285199
186Abnormality of molar morphology (HP:0011070)1.66285199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.60624001
2IRAK33.24307325
3NME23.14527615
4MUSK2.91482079
5NLK2.79543095
6MKNK22.67062253
7EIF2AK32.58016026
8PIM22.48342236
9MAP4K22.47465794
10IRAK42.45956874
11MAP3K142.44132059
12ACVR1B2.33019385
13WNK32.32569208
14EIF2AK22.25397093
15MST42.21019544
16PINK12.16124281
17CLK11.96939365
18TAOK31.96338136
19MKNK11.92450492
20INSRR1.88609237
21TEC1.88064933
22TLK11.79006487
23GRK71.72425903
24MAP3K41.62049112
25TXK1.61726147
26WNK41.58849021
27TRIM281.56959833
28TNIK1.56346606
29BLK1.53135771
30TGFBR21.53087624
31SRPK11.51660412
32TRPM71.50508119
33IKBKB1.47851383
34FGFR21.41514682
35TGFBR11.38626743
36MAP3K121.37775144
37BMPR21.36777608
38OXSR11.34553250
39IKBKE1.29740668
40BRSK21.29356776
41FER1.25556333
42YES11.22853905
43MAPKAPK31.18944993
44SGK21.18079184
45IRAK11.17475280
46GRK11.16404152
47STK391.14676821
48PAK31.13291744
49RIPK41.09700592
50MAPK131.06197979
51PIM11.06063423
52STK38L1.03059997
53FRK0.99507379
54PTK2B0.97826436
55GRK50.97589442
56TNK20.96053939
57PLK20.92267429
58PLK30.91746283
59BMPR1B0.89687754
60EPHA30.87987069
61DAPK20.87596226
62NUAK10.86269272
63DYRK20.85744868
64MAP2K60.83541089
65CSNK1G10.83338631
66PRKCG0.81559953
67CSNK1G20.80850052
68ARAF0.80729946
69BTK0.80135076
70TIE10.79776780
71PRPF4B0.79439868
72STK240.79084111
73EPHA40.77845149
74IRAK20.77446844
75MARK10.76687833
76STK160.76328501
77NME10.75353183
78MAPK120.73950771
79ERBB30.73881021
80KIT0.73350872
81ADRBK20.73074450
82CSNK1G30.72596616
83MAPK150.72537377
84WEE10.69867355
85TBK10.67393898
86CHUK0.67186490
87MAP2K70.66551984
88MAP3K90.65812838
89CAMKK20.65497902
90CDK30.65475343
91MAPKAPK50.64134684
92SGK2230.63911823
93SGK4940.63911823
94NTRK30.63193699
95BRAF0.62962423
96DYRK1B0.62843841
97FES0.60223020
98PLK40.58804834
99CSK0.58631298
100PRKD20.58490066
101BCR0.57438237
102MYLK0.57019244
103HIPK20.56982513
104LYN0.56964799
105CSNK1A1L0.55901108
106NEK60.54943821
107RPS6KA50.54314032
108CDK80.54161281
109AKT30.53050764
110DYRK30.52550070
111VRK20.51021261
112SGK30.49867601
113CDK90.49839702
114MAPK110.47551819
115TAF10.47329322
116ADRBK10.46622238
117EPHB20.45777869
118PDK20.44540683
119CAMK2A0.44510607
120VRK10.44313615
121DYRK1A0.44109728
122RPS6KA60.43972122
123RPS6KC10.43709911
124RPS6KL10.43709911
125GRK60.43421005
126PIK3CG0.42588574
127PRKG20.41713586
128SYK0.41640413
129MAPKAPK20.41111550
130PRKCE0.40828267
131ZAK0.40074694
132BCKDK0.39526406
133STK110.38985507
134STK100.38721175
135MAPK40.37700522
136PRKCQ0.37188319
137STK30.36936112
138PHKG10.36688036
139PHKG20.36688036
140PIK3CA0.36681146
141PRKACA0.35499082
142PKN10.35326383
143CSNK1A10.35264736
144MAP3K10.34535664
145EIF2AK10.34410839
146FLT30.34327428
147CSNK1D0.32873843
148PRKCI0.30990805
149MARK30.29529992
150TSSK60.29357589
151PRKAA20.29303685
152PNCK0.26975717
153PRKCA0.26951040
154CAMK10.24809326
155PRKG10.23661685

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.60835810
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.20172253
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.78736344
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61657393
5Butanoate metabolism_Homo sapiens_hsa006502.34053099
6Nitrogen metabolism_Homo sapiens_hsa009102.27363550
7Arachidonic acid metabolism_Homo sapiens_hsa005902.15917101
8Sphingolipid metabolism_Homo sapiens_hsa006002.14232518
9Olfactory transduction_Homo sapiens_hsa047402.00162593
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.99625108
11Allograft rejection_Homo sapiens_hsa053301.98481985
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93573528
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92624397
14Graft-versus-host disease_Homo sapiens_hsa053321.92580059
15Phototransduction_Homo sapiens_hsa047441.92578032
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.84395960
17Leishmaniasis_Homo sapiens_hsa051401.83705556
18Protein export_Homo sapiens_hsa030601.74118601
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.70004750
20Oxidative phosphorylation_Homo sapiens_hsa001901.69178163
21Linoleic acid metabolism_Homo sapiens_hsa005911.65460805
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61080591
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57523651
24Caffeine metabolism_Homo sapiens_hsa002321.54889966
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50980313
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50361795
27Propanoate metabolism_Homo sapiens_hsa006401.50250151
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45543637
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.44920459
30Tryptophan metabolism_Homo sapiens_hsa003801.41795149
31Measles_Homo sapiens_hsa051621.41689451
32RNA polymerase_Homo sapiens_hsa030201.40541891
33Nicotine addiction_Homo sapiens_hsa050331.40507464
34One carbon pool by folate_Homo sapiens_hsa006701.40480037
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39358918
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38641091
37Selenocompound metabolism_Homo sapiens_hsa004501.38316467
38Autoimmune thyroid disease_Homo sapiens_hsa053201.37959581
39Pertussis_Homo sapiens_hsa051331.37096815
40Ether lipid metabolism_Homo sapiens_hsa005651.36520684
41Regulation of autophagy_Homo sapiens_hsa041401.33823886
42Other glycan degradation_Homo sapiens_hsa005111.31981496
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.30489288
44Alzheimers disease_Homo sapiens_hsa050101.24864677
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.22517032
46Parkinsons disease_Homo sapiens_hsa050121.21888675
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21121780
48Hematopoietic cell lineage_Homo sapiens_hsa046401.20818512
49Peroxisome_Homo sapiens_hsa041461.20598999
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19196647
51Asthma_Homo sapiens_hsa053101.17693063
52Cardiac muscle contraction_Homo sapiens_hsa042601.17297243
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15267670
54Rheumatoid arthritis_Homo sapiens_hsa053231.14648990
55Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13352091
56Collecting duct acid secretion_Homo sapiens_hsa049661.13175140
57Staphylococcus aureus infection_Homo sapiens_hsa051501.12486107
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11755693
59Fanconi anemia pathway_Homo sapiens_hsa034601.10960426
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09171174
61Chemical carcinogenesis_Homo sapiens_hsa052041.08331547
62RNA degradation_Homo sapiens_hsa030181.07266911
63Malaria_Homo sapiens_hsa051441.03793939
64Primary bile acid biosynthesis_Homo sapiens_hsa001201.00596823
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00379046
66Homologous recombination_Homo sapiens_hsa034400.99494953
67Huntingtons disease_Homo sapiens_hsa050160.99456959
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97646086
69Tuberculosis_Homo sapiens_hsa051520.97493257
70Retinol metabolism_Homo sapiens_hsa008300.97303723
71Salmonella infection_Homo sapiens_hsa051320.96145940
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95892400
73TNF signaling pathway_Homo sapiens_hsa046680.95643103
74Fatty acid elongation_Homo sapiens_hsa000620.95433645
75p53 signaling pathway_Homo sapiens_hsa041150.93936746
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93743126
77Circadian rhythm_Homo sapiens_hsa047100.91934181
78Primary immunodeficiency_Homo sapiens_hsa053400.91915506
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89486180
80ABC transporters_Homo sapiens_hsa020100.88670407
81Osteoclast differentiation_Homo sapiens_hsa043800.88299428
82Insulin secretion_Homo sapiens_hsa049110.86757789
83Herpes simplex infection_Homo sapiens_hsa051680.86382426
84Sulfur metabolism_Homo sapiens_hsa009200.85598674
85Histidine metabolism_Homo sapiens_hsa003400.83463121
86Hepatitis C_Homo sapiens_hsa051600.82290247
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81306487
88Legionellosis_Homo sapiens_hsa051340.81240052
89Non-homologous end-joining_Homo sapiens_hsa034500.80270682
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77972967
91Apoptosis_Homo sapiens_hsa042100.77261975
92Metabolic pathways_Homo sapiens_hsa011000.72307761
93beta-Alanine metabolism_Homo sapiens_hsa004100.70247859
94Influenza A_Homo sapiens_hsa051640.69154231
95Taste transduction_Homo sapiens_hsa047420.68755762
96Chemokine signaling pathway_Homo sapiens_hsa040620.68657336
97Toxoplasmosis_Homo sapiens_hsa051450.67023457
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65835037
99GABAergic synapse_Homo sapiens_hsa047270.64621577
100Ovarian steroidogenesis_Homo sapiens_hsa049130.63842707
101Acute myeloid leukemia_Homo sapiens_hsa052210.63665983
102Basal cell carcinoma_Homo sapiens_hsa052170.63325945
103Glutamatergic synapse_Homo sapiens_hsa047240.62956971
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.62816806
105Purine metabolism_Homo sapiens_hsa002300.61820182
106Fat digestion and absorption_Homo sapiens_hsa049750.61562390
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.60933053
108Serotonergic synapse_Homo sapiens_hsa047260.60560781
109Circadian entrainment_Homo sapiens_hsa047130.59601780
110Salivary secretion_Homo sapiens_hsa049700.59530058
111Pyrimidine metabolism_Homo sapiens_hsa002400.59350943
112Dorso-ventral axis formation_Homo sapiens_hsa043200.59260482
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58615438
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58405234
115Fatty acid metabolism_Homo sapiens_hsa012120.56745467
116Steroid biosynthesis_Homo sapiens_hsa001000.55971987
117Vitamin digestion and absorption_Homo sapiens_hsa049770.55919759
118Proteasome_Homo sapiens_hsa030500.55192882
119Fatty acid degradation_Homo sapiens_hsa000710.52904518
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52776754
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52571041
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52459657
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52118018
124Type I diabetes mellitus_Homo sapiens_hsa049400.51770947
125Basal transcription factors_Homo sapiens_hsa030220.51696644
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.51235125
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51084574
128Glutathione metabolism_Homo sapiens_hsa004800.51076571
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50790876
130African trypanosomiasis_Homo sapiens_hsa051430.49256202
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48790997
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47886770
133Platelet activation_Homo sapiens_hsa046110.47085495
134Phagosome_Homo sapiens_hsa041450.46461796
135Shigellosis_Homo sapiens_hsa051310.46112085
136Calcium signaling pathway_Homo sapiens_hsa040200.45774513
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45456772
138Nucleotide excision repair_Homo sapiens_hsa034200.42458306
139Arginine and proline metabolism_Homo sapiens_hsa003300.41800879
140Melanogenesis_Homo sapiens_hsa049160.41720040
141Prostate cancer_Homo sapiens_hsa052150.40179971
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39040434
143Hepatitis B_Homo sapiens_hsa051610.36140869
144Dopaminergic synapse_Homo sapiens_hsa047280.35963294
145Fatty acid biosynthesis_Homo sapiens_hsa000610.35572869
146Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35012488
147Morphine addiction_Homo sapiens_hsa050320.34599656
148Mineral absorption_Homo sapiens_hsa049780.32996859
149Ras signaling pathway_Homo sapiens_hsa040140.31991108
150Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31945426

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