RNF224

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)9.00515165
2translational termination (GO:0006415)8.65870064
3ribosomal small subunit assembly (GO:0000028)7.93846199
4ribosomal small subunit biogenesis (GO:0042274)7.55055384
5translational elongation (GO:0006414)7.23525559
6protein carboxylation (GO:0018214)7.22477112
7peptidyl-glutamic acid carboxylation (GO:0017187)7.22477112
8GDP-mannose metabolic process (GO:0019673)7.14281662
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.10723196
10cotranslational protein targeting to membrane (GO:0006613)6.98968169
11protein targeting to ER (GO:0045047)6.95902375
12maturation of SSU-rRNA (GO:0030490)6.85588245
13cellular protein complex disassembly (GO:0043624)6.71959982
14establishment of protein localization to endoplasmic reticulum (GO:0072599)6.66503079
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.54376825
16protein localization to endoplasmic reticulum (GO:0070972)6.49396201
17viral life cycle (GO:0019058)6.40816022
18regulation of skeletal muscle contraction (GO:0014819)6.34254783
19interferon-gamma secretion (GO:0072643)6.18747476
20translational initiation (GO:0006413)5.89545711
21cellular response to ATP (GO:0071318)5.88291072
22DNA strand renaturation (GO:0000733)5.84680823
23proline biosynthetic process (GO:0006561)5.77314550
24protein complex disassembly (GO:0043241)5.75205405
25semaphorin-plexin signaling pathway (GO:0071526)5.57768016
26glutamine family amino acid biosynthetic process (GO:0009084)5.38342589
27mitotic cell cycle arrest (GO:0071850)5.19660282
28macromolecular complex disassembly (GO:0032984)5.09822033
29L-fucose metabolic process (GO:0042354)4.90479176
30L-fucose catabolic process (GO:0042355)4.90479176
31fucose catabolic process (GO:0019317)4.90479176
32ribosomal large subunit biogenesis (GO:0042273)4.90090417
33mannose metabolic process (GO:0006013)4.89964587
34DNA deamination (GO:0045006)4.85361164
35protein targeting to membrane (GO:0006612)4.81361826
36pentose-phosphate shunt (GO:0006098)4.77230203
37regulation of cytokine production involved in inflammatory response (GO:1900015)4.63483184
38transepithelial transport (GO:0070633)4.61071142
39amino sugar catabolic process (GO:0046348)4.53245585
40proline metabolic process (GO:0006560)4.51100227
41regulation of synapse structural plasticity (GO:0051823)4.44918235
42negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.43020304
43adenosine receptor signaling pathway (GO:0001973)4.40169515
44meiotic chromosome segregation (GO:0045132)4.36067481
45wound healing, spreading of epidermal cells (GO:0035313)4.32741150
46NADPH regeneration (GO:0006740)4.31096884
47nuclear-transcribed mRNA catabolic process (GO:0000956)4.25637758
48phosphate ion homeostasis (GO:0055062)4.21730308
49trivalent inorganic anion homeostasis (GO:0072506)4.21730308
50positive regulation of mast cell activation involved in immune response (GO:0033008)4.16754511
51positive regulation of mast cell degranulation (GO:0043306)4.16754511
52regulation of cholesterol biosynthetic process (GO:0045540)4.13802565
53hepatocyte differentiation (GO:0070365)4.11106844
54pentose metabolic process (GO:0019321)4.01734368
55mRNA catabolic process (GO:0006402)4.01686471
56UV protection (GO:0009650)3.99289010
57protein retention in ER lumen (GO:0006621)3.98548265
58sphingosine metabolic process (GO:0006670)3.94106916
59sphingomyelin metabolic process (GO:0006684)3.92969759
60folic acid metabolic process (GO:0046655)3.88295244
61sequestering of extracellular ligand from receptor (GO:0035581)3.88022104
62diol metabolic process (GO:0034311)3.80407346
63planar cell polarity pathway involved in neural tube closure (GO:0090179)3.79983929
64translation (GO:0006412)3.76286856
65cellular anion homeostasis (GO:0030002)3.76025257
66ribonucleoprotein complex biogenesis (GO:0022613)3.74787558
67positive regulation of protein kinase C signaling (GO:0090037)3.74751320
68G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.74728286
69skin morphogenesis (GO:0043589)3.73903527
70hemidesmosome assembly (GO:0031581)3.73519058
71RNA catabolic process (GO:0006401)3.72436820
72establishment of protein localization to membrane (GO:0090150)3.72265488
73maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.70639507
74sulfur amino acid catabolic process (GO:0000098)3.70358760
75lens fiber cell differentiation (GO:0070306)3.70266546
76regulation of cholesterol metabolic process (GO:0090181)3.69309722
77sensory perception of taste (GO:0050909)3.57883759
78nucleotide-sugar biosynthetic process (GO:0009226)3.54823354
79phosphate ion transmembrane transport (GO:0035435)3.52953811
80negative regulation of cell aging (GO:0090344)3.52366401
81keratinocyte proliferation (GO:0043616)3.51550110
82regulation of gene silencing by RNA (GO:0060966)3.50540353
83regulation of posttranscriptional gene silencing (GO:0060147)3.50540353
84regulation of gene silencing by miRNA (GO:0060964)3.50540353
85positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.50081602
86CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.43928330
87adenine nucleotide transport (GO:0051503)3.38490623
88regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.36959736
89endocytic recycling (GO:0032456)3.36666172
90glucosamine-containing compound catabolic process (GO:1901072)3.35078191
91Golgi transport vesicle coating (GO:0048200)3.34005286
92COPI coating of Golgi vesicle (GO:0048205)3.34005286
93purine ribonucleotide transport (GO:0015868)3.33542268
94platelet dense granule organization (GO:0060155)3.33093471
95hexose catabolic process (GO:0019320)3.32427620
96pseudouridine synthesis (GO:0001522)3.32187816
97regulation of phospholipid biosynthetic process (GO:0071071)3.31205774
98purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.30824913
99ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.30824913
100nucleoside bisphosphate biosynthetic process (GO:0033866)3.30824913
101positive regulation of leukocyte degranulation (GO:0043302)3.28091463
102protein insertion into membrane (GO:0051205)3.22072597
103regulation of translational fidelity (GO:0006450)3.21425548
104estrogen biosynthetic process (GO:0006703)3.20764887
105regulation of mammary gland epithelial cell proliferation (GO:0033599)3.17170656
106platelet aggregation (GO:0070527)3.16504496
107negative regulation of interleukin-8 production (GO:0032717)3.14822752
108response to ATP (GO:0033198)3.14285187
109nucleoside transmembrane transport (GO:1901642)3.12906089
110glucose catabolic process (GO:0006007)3.12081397
111transcription elongation from RNA polymerase III promoter (GO:0006385)3.12005537
112termination of RNA polymerase III transcription (GO:0006386)3.12005537
113purinergic nucleotide receptor signaling pathway (GO:0035590)3.11191220
114phosphatidylglycerol biosynthetic process (GO:0006655)3.10064913
115urogenital system development (GO:0001655)3.07946544
116epithelial cell-cell adhesion (GO:0090136)3.07866192
117positive regulation of mast cell activation (GO:0033005)3.06147855
118regulation of water loss via skin (GO:0033561)3.05139917
119rRNA processing (GO:0006364)3.04739676
120phosphatidylethanolamine biosynthetic process (GO:0006646)3.03429622
121regulation of cell aging (GO:0090342)2.98868014
122negative regulation of cell size (GO:0045792)2.97849292
123L-serine metabolic process (GO:0006563)2.96021838
124purine nucleotide transport (GO:0015865)2.94226322
125regulation of ARF GTPase activity (GO:0032312)2.93528360
126monosaccharide catabolic process (GO:0046365)2.91846663
127glutathione biosynthetic process (GO:0006750)2.90819668
128rRNA metabolic process (GO:0016072)2.89880718
129protein localization to membrane (GO:0072657)2.88987048
130pinocytosis (GO:0006907)2.88665985
131N-acetylneuraminate metabolic process (GO:0006054)2.86599846
132positive regulation of heat generation (GO:0031652)2.85528507
133glutamate metabolic process (GO:0006536)2.84446325
134granulocyte differentiation (GO:0030851)2.84047515
135placenta development (GO:0001890)2.82982609
1364-hydroxyproline metabolic process (GO:0019471)2.82718482
137type B pancreatic cell proliferation (GO:0044342)2.82417622
138establishment of apical/basal cell polarity (GO:0035089)2.82415834
139DNA duplex unwinding (GO:0032508)2.82329829
140focal adhesion assembly (GO:0048041)2.81546413
141cell-substrate adherens junction assembly (GO:0007045)2.81546413
142intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.81479617
143DNA unwinding involved in DNA replication (GO:0006268)2.81082366
144wound healing, spreading of cells (GO:0044319)2.80752618
145folic acid transport (GO:0015884)2.80665242
146phosphate ion transport (GO:0006817)2.80602302
147sphingoid metabolic process (GO:0046519)2.80465524
148desmosome organization (GO:0002934)2.79921141
149detection of light stimulus involved in sensory perception (GO:0050962)2.79631850
150detection of light stimulus involved in visual perception (GO:0050908)2.79631850
151establishment of skin barrier (GO:0061436)2.79477420
152actin filament bundle organization (GO:0061572)2.79163465
153actin filament bundle assembly (GO:0051017)2.79163465
154protein targeting (GO:0006605)2.79013401
155regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.78376324
156cellular response to thyroid hormone stimulus (GO:0097067)2.76384906
157activation of Rac GTPase activity (GO:0032863)2.75830466
158cilium or flagellum-dependent cell motility (GO:0001539)2.75215998
159regulation of fatty acid beta-oxidation (GO:0031998)2.74993555
160inner cell mass cell proliferation (GO:0001833)2.74858416
161positive regulation of osteoblast proliferation (GO:0033690)2.74299096
162labyrinthine layer blood vessel development (GO:0060716)2.72787516
163basement membrane organization (GO:0071711)2.72274942
164dopamine transport (GO:0015872)2.70701768
165cell-cell junction maintenance (GO:0045217)2.70605017
166renal absorption (GO:0070293)2.70291956
167DNA strand elongation involved in DNA replication (GO:0006271)2.70133787
168embryonic body morphogenesis (GO:0010172)2.68247022
169glomerulus development (GO:0032835)2.67873041
170activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.67413862
171regulation of DNA endoreduplication (GO:0032875)2.67390406
172rRNA methylation (GO:0031167)2.67135686
173phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.66827698
174lung epithelium development (GO:0060428)2.66595459
175cellular component biogenesis (GO:0044085)2.66495017
176eyelid development in camera-type eye (GO:0061029)2.64226650
177spinal cord association neuron differentiation (GO:0021527)2.63093393
178DNA strand elongation (GO:0022616)2.62504850
179head development (GO:0060322)2.61774266
180ribosome assembly (GO:0042255)2.60791251
181regulation of cholesterol homeostasis (GO:2000188)2.60547425
182oligosaccharide catabolic process (GO:0009313)2.60538425
183imidazole-containing compound metabolic process (GO:0052803)2.60434530
184DNA geometric change (GO:0032392)2.59498481
185response to thyroid hormone (GO:0097066)2.59351161
186negative regulation of bone mineralization (GO:0030502)2.59020253
187atrioventricular valve morphogenesis (GO:0003181)2.58310002
188cardiolipin metabolic process (GO:0032048)2.58305885
189establishment of protein localization to organelle (GO:0072594)2.57782251
190reactive oxygen species biosynthetic process (GO:1903409)2.56191927
191nonribosomal peptide biosynthetic process (GO:0019184)2.55714901
192phosphatidylethanolamine metabolic process (GO:0046337)2.55059807
193snRNA metabolic process (GO:0016073)2.52948580
194very-low-density lipoprotein particle assembly (GO:0034379)2.52854123
195NADP metabolic process (GO:0006739)2.52843000
196negative regulation of fatty acid transport (GO:2000192)2.50150826
197peptidyl-glutamic acid modification (GO:0018200)2.49832880

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.25054025
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.12776817
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.11370788
4STAT6_21828071_ChIP-Seq_BEAS2B_Human4.02697744
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.77359025
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.67195096
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.20030757
8ZNF263_19887448_ChIP-Seq_K562_Human3.17464035
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.83504949
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66525000
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.58391328
12P68_20966046_ChIP-Seq_HELA_Human2.58101201
13IRF1_19129219_ChIP-ChIP_H3396_Human2.55152965
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38656543
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.38495173
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.36449195
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33428546
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.29532269
19E2F7_22180533_ChIP-Seq_HELA_Human2.28399724
20DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.23687368
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.22585916
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.13598351
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.08847693
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.04885178
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.98891128
26TET1_21451524_ChIP-Seq_MESCs_Mouse1.97006270
27CTCF_27219007_Chip-Seq_ERYTHROID_Human1.95013956
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94264069
29VDR_21846776_ChIP-Seq_THP-1_Human1.92195965
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.90235728
31MAF_26560356_Chip-Seq_TH2_Human1.89289699
32SMC4_20622854_ChIP-Seq_HELA_Human1.87883551
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86135219
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.85544533
35E2F1_20622854_ChIP-Seq_HELA_Human1.84481178
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84269186
37CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.83452123
38BCOR_27268052_Chip-Seq_Bcells_Human1.79487850
39CLOCK_20551151_ChIP-Seq_293T_Human1.78704321
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.75534352
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.74674444
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73415131
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70771828
44RARB_24833708_ChIP-Seq_LIVER_Mouse1.68757582
45CREB1_26743006_Chip-Seq_LNCaP_Human1.67535549
46PHF8_20622854_ChIP-Seq_HELA_Human1.67137882
47KDM2B_26808549_Chip-Seq_DND41_Human1.67060928
48MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.65799095
49CTCF_27219007_Chip-Seq_Bcells_Human1.63314084
50RARA_24833708_ChIP-Seq_LIVER_Mouse1.62517785
51HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.61669703
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61123222
53BCL6_27268052_Chip-Seq_Bcells_Human1.61075651
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.60110580
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.59634581
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58769142
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55766562
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55522531
59MAF_26560356_Chip-Seq_TH1_Human1.54053698
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53709512
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53435197
62* FOXP1_21924763_ChIP-Seq_HESCs_Human1.50993582
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.50926307
64RXRA_24833708_ChIP-Seq_LIVER_Mouse1.50264360
65RUNX1_27514584_Chip-Seq_MCF-7_Human1.49871031
66SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48727565
67XRN2_22483619_ChIP-Seq_HELA_Human1.48593676
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45412159
69EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44885580
70ATF3_27146783_Chip-Seq_COLON_Human1.43540037
71TP53_22127205_ChIP-Seq_IMR90_Human1.43479364
72PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42896396
73P63_26484246_Chip-Seq_KERATINOCYTES_Human1.41351705
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.41274666
75CTCF_21964334_Chip-Seq_Bcells_Human1.40073976
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.38491096
77MYC_18940864_ChIP-ChIP_HL60_Human1.37954637
78RACK7_27058665_Chip-Seq_MCF-7_Human1.37575301
79KDM2B_26808549_Chip-Seq_K562_Human1.36812004
80SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36046550
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34576542
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32017519
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.32006705
84VDR_24763502_ChIP-Seq_THP-1_Human1.28776783
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26129874
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.22909588
87CTCF_21964334_ChIP-Seq_BJAB-B_Human1.22737245
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22511396
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22283960
90CTCF_20526341_ChIP-Seq_ESCs_Human1.21771325
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19512856
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.19051972
93ETS1_21867929_ChIP-Seq_TH2_Mouse1.18623946
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18133618
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17817914
96UBF1/2_26484160_Chip-Seq_HMECs_Human1.15573041
97GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15531988
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14225232
99NCOR1_26117541_ChIP-Seq_K562_Human1.13918797
100NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13132914
101FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12951119
102RXR_22158963_ChIP-Seq_LIVER_Mouse1.12737275
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12328298
104CTCF_26484167_Chip-Seq_Bcells_Mouse1.10857845
105HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10663290
106FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10649743
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09927020
108FOXO3_23340844_ChIP-Seq_DLD1_Human1.09721613
109GABP_19822575_ChIP-Seq_HepG2_Human1.09649689
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09542190
111SA1_27219007_Chip-Seq_Bcells_Human1.09105335
112NANOG_18692474_ChIP-Seq_MEFs_Mouse1.09008349
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08617952
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07972471
115OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07945280
116STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07685513
117TP63_22573176_ChIP-Seq_HFKS_Human1.07545716
118SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07358946
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.07214807
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07198391
121JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.07051906
122HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07026158
123GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06477951
124AR_21909140_ChIP-Seq_LNCAP_Human1.06157973
125E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06014815
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05983532
127CDX2_20551321_ChIP-Seq_CACO-2_Human1.05536171
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05150647
129CIITA_25753668_ChIP-Seq_RAJI_Human1.04787616
130SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04553230
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04091134
132UTX_26944678_Chip-Seq_JUKART_Human1.03791210
133TCF7_22412390_ChIP-Seq_EML_Mouse1.03319316
134SPI1_20517297_ChIP-Seq_HL60_Human1.03016778
135MYC_22102868_ChIP-Seq_BL_Human1.01725823
136TTF2_22483619_ChIP-Seq_HELA_Human1.00978079
137PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00736717
138SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99813912
139SA1_27219007_Chip-Seq_ERYTHROID_Human0.98654401
140CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98503778
141MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97762524
142NOTCH1_21737748_ChIP-Seq_TLL_Human0.97400178
143SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96028437
144TP53_20018659_ChIP-ChIP_R1E_Mouse0.91949769
145ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90798882
146MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90062217
147RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89192137
148KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88574392
149UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86962959
150SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86682151
151KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86495905
152NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85840881
153TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85116828
154SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85021765
155SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85021765
156ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84946904
157SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.84723718
158KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84581749
159NANOG_18555785_ChIP-Seq_MESCs_Mouse0.83702555
160LXR_22292898_ChIP-Seq_THP-1_Human0.83665788
161EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83281438
162CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82204028
163IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81907571
164HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81541488
165ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81226659
166BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80850307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation5.09984662
2MP0009379_abnormal_foot_pigmentation5.01868951
3MP0003123_paternal_imprinting4.77988146
4MP0003941_abnormal_skin_development4.44766039
5MP0003705_abnormal_hypodermis_morpholog3.95230202
6MP0008875_abnormal_xenobiotic_pharmacok3.66709514
7MP0002132_abnormal_respiratory_system3.46420188
8MP0005397_hematopoietic_system_phenotyp3.18731108
9MP0001545_abnormal_hematopoietic_system3.18731108
10MP0005423_abnormal_somatic_nervous3.14126745
11MP0000383_abnormal_hair_follicle3.00269763
12MP0010234_abnormal_vibrissa_follicle2.98587660
13MP0003566_abnormal_cell_adhesion2.95746227
14MP0001661_extended_life_span2.81457516
15MP0005083_abnormal_biliary_tract2.65438357
16MP0005058_abnormal_lysosome_morphology2.58119863
17MP0000751_myopathy2.52294738
18MP0004264_abnormal_extraembryonic_tissu2.47362393
19MP0002254_reproductive_system_inflammat2.44249329
20MP0005076_abnormal_cell_differentiation2.32556469
21MP0005409_darkened_coat_color2.30139561
22MP0004381_abnormal_hair_follicle2.27731579
23MP0008057_abnormal_DNA_replication2.13555244
24MP0002796_impaired_skin_barrier2.11634273
25MP0005330_cardiomyopathy2.11140580
26MP0005501_abnormal_skin_physiology2.08983855
27MP0003045_fibrosis2.08436763
28MP0003111_abnormal_nucleus_morphology2.07236884
29MP0000467_abnormal_esophagus_morphology2.04751655
30MP0010678_abnormal_skin_adnexa2.00534147
31MP0004808_abnormal_hematopoietic_stem2.00487558
32MP0000858_altered_metastatic_potential1.99213529
33MP0001188_hyperpigmentation1.98513378
34MP0004947_skin_inflammation1.98437504
35MP0005174_abnormal_tail_pigmentation1.95605223
36MP0005257_abnormal_intraocular_pressure1.88086281
37MP0003172_abnormal_lysosome_physiology1.81025238
38MP0001756_abnormal_urination1.78215598
39MP0003806_abnormal_nucleotide_metabolis1.74314902
40MP0004185_abnormal_adipocyte_glucose1.72111491
41MP0000465_gastrointestinal_hemorrhage1.71181803
42MP0000003_abnormal_adipose_tissue1.68961879
43MP0008007_abnormal_cellular_replicative1.65010345
44MP0001348_abnormal_lacrimal_gland1.64735265
45MP0002396_abnormal_hematopoietic_system1.61739742
46MP0002160_abnormal_reproductive_system1.61100002
47MP0000750_abnormal_muscle_regeneration1.60770816
48MP0009384_cardiac_valve_regurgitation1.53559345
49MP0005332_abnormal_amino_acid1.48654715
50MP0004957_abnormal_blastocyst_morpholog1.44187423
51MP0002877_abnormal_melanocyte_morpholog1.44014193
52MP0001502_abnormal_circadian_rhythm1.43241732
53MP0000013_abnormal_adipose_tissue1.40487643
54MP0001958_emphysema1.39972410
55MP0009931_abnormal_skin_appearance1.37377328
56MP0004019_abnormal_vitamin_homeostasis1.36814426
57MP0005636_abnormal_mineral_homeostasis1.36491273
58MP0003121_genomic_imprinting1.35785150
59MP0010352_gastrointestinal_tract_polyps1.33807163
60MP0002089_abnormal_postnatal_growth/wei1.32822155
61MP0000747_muscle_weakness1.32268064
62MP0000490_abnormal_crypts_of1.32103559
63MP0004858_abnormal_nervous_system1.31473310
64MP0001216_abnormal_epidermal_layer1.31125185
65MP0003638_abnormal_response/metabolism_1.26115693
66MP0003724_increased_susceptibility_to1.25132984
67MP0008872_abnormal_physiological_respon1.23691427
68MP0001666_abnormal_nutrient_absorption1.23456560
69MP0002098_abnormal_vibrissa_morphology1.22681747
70MP0001849_ear_inflammation1.21374852
71MP0000427_abnormal_hair_cycle1.20492615
72MP0000647_abnormal_sebaceous_gland1.18133038
73MP0000015_abnormal_ear_pigmentation1.15949861
74MP0003453_abnormal_keratinocyte_physiol1.15570653
75MP0003136_yellow_coat_color1.13557540
76MP0001664_abnormal_digestion1.10766373
77MP0008789_abnormal_olfactory_epithelium1.10128908
78MP0009643_abnormal_urine_homeostasis1.10127303
79MP0005360_urolithiasis1.08474068
80MP0010030_abnormal_orbit_morphology1.07465229
81MP0001293_anophthalmia1.06769853
82MP0005464_abnormal_platelet_physiology1.04626354
83MP0003091_abnormal_cell_migration1.02706343
84MP0001919_abnormal_reproductive_system1.02496610
85MP0010771_integument_phenotype1.01104960
86MP0005666_abnormal_adipose_tissue1.00506967
87MP0002249_abnormal_larynx_morphology0.99762599
88MP0002938_white_spotting0.99464516
89MP0005379_endocrine/exocrine_gland_phen0.98625674
90MP0003787_abnormal_imprinting0.97711487
91MP0005377_hearing/vestibular/ear_phenot0.97489416
92MP0003878_abnormal_ear_physiology0.97489416
93MP0003077_abnormal_cell_cycle0.97349710
94MP0004130_abnormal_muscle_cell0.97252461
95MP0002148_abnormal_hypersensitivity_rea0.96684625
96MP0005375_adipose_tissue_phenotype0.96676612
97MP0001346_abnormal_lacrimal_gland0.96424689
98MP0004043_abnormal_pH_regulation0.95285406
99MP0000685_abnormal_immune_system0.94316424
100MP0002086_abnormal_extraembryonic_tissu0.93765574
101MP0005451_abnormal_body_composition0.92456558
102MP0002909_abnormal_adrenal_gland0.92241616
103MP0001873_stomach_inflammation0.92159425
104MP0003938_abnormal_ear_development0.90914151
105MP0005023_abnormal_wound_healing0.90479230
106MP0004272_abnormal_basement_membrane0.89920118
107MP0005365_abnormal_bile_salt0.89024630
108MP0002060_abnormal_skin_morphology0.87250041
109MP0004233_abnormal_muscle_weight0.87130054
110MP0000538_abnormal_urinary_bladder0.85460243
111MP0005075_abnormal_melanosome_morpholog0.85326752
112MP0001986_abnormal_taste_sensitivity0.84784001
113MP0009703_decreased_birth_body0.84231716
114MP0000470_abnormal_stomach_morphology0.84125690
115MP0001765_abnormal_ion_homeostasis0.82451850
116MP0009840_abnormal_foam_cell0.81572352
117MP0000372_irregular_coat_pigmentation0.81101145
118MP0001968_abnormal_touch/_nociception0.80951296
119MP0005410_abnormal_fertilization0.79481018
120MP0009333_abnormal_splenocyte_physiolog0.79458029
121MP0009672_abnormal_birth_weight0.79228564
122MP0004782_abnormal_surfactant_physiolog0.78634835
123MP0005623_abnormal_meninges_morphology0.78318776
124MP0001915_intracranial_hemorrhage0.76773933
125MP0000762_abnormal_tongue_morphology0.76215259
126MP0002080_prenatal_lethality0.76104648
127MP0003115_abnormal_respiratory_system0.75743976
128MP0003303_peritoneal_inflammation0.74239212
129MP0001191_abnormal_skin_condition0.72988688
130MP0002075_abnormal_coat/hair_pigmentati0.72428768
131MP0004087_abnormal_muscle_fiber0.71475522
132MP0008770_decreased_survivor_rate0.71242023
133MP0000477_abnormal_intestine_morphology0.70619124
134MP0000678_abnormal_parathyroid_gland0.70175742
135MP0003693_abnormal_embryo_hatching0.69893725
136MP0005584_abnormal_enzyme/coenzyme_acti0.69666625
137MP0005388_respiratory_system_phenotype0.69244084
138MP0002133_abnormal_respiratory_system0.69244084
139MP0005499_abnormal_olfactory_system0.69212278
140MP0005394_taste/olfaction_phenotype0.69212278
141MP0009785_altered_susceptibility_to0.68003563
142MP0000377_abnormal_hair_follicle0.67561414
143MP0004197_abnormal_fetal_growth/weight/0.67441050
144MP0008932_abnormal_embryonic_tissue0.65162199
145MP0010094_abnormal_chromosome_stability0.64448357
146MP0000579_abnormal_nail_morphology0.64046051
147MP0000537_abnormal_urethra_morphology0.63783137
148MP0005275_abnormal_skin_tensile0.63491158
149MP0002118_abnormal_lipid_homeostasis0.63432213
150MP0002735_abnormal_chemical_nociception0.62476821
151MP0002136_abnormal_kidney_physiology0.62311519
152MP0002419_abnormal_innate_immunity0.62156910
153MP0005220_abnormal_exocrine_pancreas0.61700088
154MP0003656_abnormal_erythrocyte_physiolo0.61608403
155MP0004147_increased_porphyrin_level0.61056075
156MP0000367_abnormal_coat/_hair0.59226556
157MP0009763_increased_sensitivity_to0.59018315
158MP0000358_abnormal_cell_content/0.58918523

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)8.80642867
2Abnormal number of erythroid precursors (HP:0012131)8.54690472
3Petechiae (HP:0000967)6.92160680
4Testicular atrophy (HP:0000029)6.90750291
5Thin bony cortex (HP:0002753)6.05096299
6Macrocytic anemia (HP:0001972)5.78435793
7Hemorrhage of the eye (HP:0011885)5.08157925
8Reticulocytopenia (HP:0001896)5.07530604
9Mesangial abnormality (HP:0001966)5.04460896
10Ulnar bowing (HP:0003031)4.94072949
11Pallor (HP:0000980)4.62295028
12Rib fusion (HP:0000902)4.56870349
13Akinesia (HP:0002304)4.39638495
14Dyschromatopsia (HP:0007641)4.38615627
15Poikiloderma (HP:0001029)4.29859847
16Abnormality of the heme biosynthetic pathway (HP:0010472)4.28048686
17Hypoplasia of the pons (HP:0012110)4.26285421
18Acanthocytosis (HP:0001927)4.24928232
19Prolonged partial thromboplastin time (HP:0003645)4.21831113
20Vaginal fistula (HP:0004320)4.07145591
21Attenuation of retinal blood vessels (HP:0007843)4.04786111
22Joint hemorrhage (HP:0005261)4.02988055
23Short middle phalanx of the 5th finger (HP:0004220)3.96068373
24Abnormality of reticulocytes (HP:0004312)3.95157910
25Popliteal pterygium (HP:0009756)3.92183385
26Abnormality of the pons (HP:0007361)3.90759702
27Rectal fistula (HP:0100590)3.89396632
28Rectovaginal fistula (HP:0000143)3.89396632
29Abnormality of the intrinsic pathway (HP:0010989)3.82555959
30Intestinal fistula (HP:0100819)3.80692846
31Broad face (HP:0000283)3.76251404
32Annular pancreas (HP:0001734)3.75887517
33Facial hemangioma (HP:0000329)3.75119463
34Turricephaly (HP:0000262)3.68419473
35Delayed epiphyseal ossification (HP:0002663)3.67303607
36Aplasia of the musculature (HP:0100854)3.54932210
37Parakeratosis (HP:0001036)3.48889348
38Reticulocytosis (HP:0001923)3.31948269
39Squamous cell carcinoma (HP:0002860)3.31551790
40Prolonged bleeding time (HP:0003010)3.28053579
41Abnormal platelet function (HP:0011869)3.20200806
42Impaired platelet aggregation (HP:0003540)3.20200806
43Cervical subluxation (HP:0003308)3.13181102
44Facial diplegia (HP:0001349)3.08795311
45Choroideremia (HP:0001139)3.02503217
46Abnormal sex determination (HP:0012244)3.02391139
47Sex reversal (HP:0012245)3.02391139
48Megaloblastic anemia (HP:0001889)3.01659203
49Hypophosphatemic rickets (HP:0004912)3.00877384
50Aplastic anemia (HP:0001915)2.99791292
51Coronal craniosynostosis (HP:0004440)2.99460434
52Anteriorly placed anus (HP:0001545)2.95827192
53Brushfield spots (HP:0001088)2.95311651
54Widely patent fontanelles and sutures (HP:0004492)2.94764555
55Confusion (HP:0001289)2.91857088
56Onycholysis (HP:0001806)2.89259461
57Cone-rod dystrophy (HP:0000548)2.85635170
58Chronic bronchitis (HP:0004469)2.84315730
59Fetal akinesia sequence (HP:0001989)2.83580448
60Joint stiffness (HP:0001387)2.83573633
61Atrioventricular block (HP:0001678)2.80886226
62Renal Fanconi syndrome (HP:0001994)2.79164972
63Zonular cataract (HP:0010920)2.77684392
64Abnormality of the costochondral junction (HP:0000919)2.76645249
65Milia (HP:0001056)2.76573529
66Mucopolysacchariduria (HP:0008155)2.74801737
67Urinary glycosaminoglycan excretion (HP:0003541)2.74801737
68Enlarged epiphyses (HP:0010580)2.74611137
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.68205355
70Bowing of the arm (HP:0006488)2.67968597
71Bowed forearm bones (HP:0003956)2.67968597
72Increased hepatocellular lipid droplets (HP:0006565)2.67209199
73Abnormality of the common coagulation pathway (HP:0010990)2.66609203
74Abnormality of mucopolysaccharide metabolism (HP:0011020)2.66360900
75Abnormality of polysaccharide metabolism (HP:0011012)2.66360900
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.66360900
77Fragile nails (HP:0001808)2.59873422
78Neonatal onset (HP:0003623)2.56090722
79Type II lissencephaly (HP:0007260)2.53062483
80Thin ribs (HP:0000883)2.52742946
81Amniotic constriction ring (HP:0009775)2.52459968
82Abnormality of placental membranes (HP:0011409)2.52459968
83Intrahepatic cholestasis (HP:0001406)2.51315430
84Lipid accumulation in hepatocytes (HP:0006561)2.47831795
85White forelock (HP:0002211)2.47748334
86Decreased electroretinogram (ERG) amplitude (HP:0000654)2.44536311
87Bony spicule pigmentary retinopathy (HP:0007737)2.42497497
88Abnormal epiphyseal ossification (HP:0010656)2.41217051
89Myopathic facies (HP:0002058)2.37046000
90Neonatal respiratory distress (HP:0002643)2.36396697
91Abnormality of the vitamin B12 metabolism (HP:0004341)2.34697719
92Mediastinal lymphadenopathy (HP:0100721)2.34554674
93Abnormal urine phosphate concentration (HP:0012599)2.34090544
94Capillary hemangiomas (HP:0005306)2.30304792
95Choanal stenosis (HP:0000452)2.29086992
96Polycythemia (HP:0001901)2.28724524
97Decreased central vision (HP:0007663)2.28210201
98Abnormal albumin level (HP:0012116)2.25625240
99Hypoalbuminemia (HP:0003073)2.25625240
100Wide cranial sutures (HP:0010537)2.25045707
101Childhood onset (HP:0011463)2.24600414
102Flat occiput (HP:0005469)2.23746714
103Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23023044
104Pustule (HP:0200039)2.22279874
105Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22147644
106Thick nail (HP:0001805)2.21922319
107Patellar aplasia (HP:0006443)2.21180143
108Myotonia (HP:0002486)2.20040663
109Aplasia cutis congenita (HP:0001057)2.18659280
110Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18385011
111Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.17987787
112Abnormality of vitamin B metabolism (HP:0004340)2.16827849
113Plantar hyperkeratosis (HP:0007556)2.16554965
114Epiphyseal stippling (HP:0010655)2.16422642
115Recurrent corneal erosions (HP:0000495)2.16221336
116Aplasia/Hypoplasia of the patella (HP:0006498)2.11551621
117Exertional dyspnea (HP:0002875)2.11012187
118Morphological abnormality of the middle ear (HP:0008609)2.09615917
119Woolly hair (HP:0002224)2.09331899
120Diminished movement (HP:0002374)2.09197549
121Atrophic scars (HP:0001075)2.08690380
122Migraine (HP:0002076)2.08408530
123Patchy hypopigmentation of hair (HP:0011365)2.08388016
124Morphological abnormality of the inner ear (HP:0011390)2.07894628
125Abnormality of serum amino acid levels (HP:0003112)2.06631537
126Increased serum ferritin (HP:0003281)2.04589717
127Cheilitis (HP:0100825)2.04560521
128Abnormal hemoglobin (HP:0011902)2.00665713
129Chronic otitis media (HP:0000389)1.98446960
130Cholelithiasis (HP:0001081)1.96967469
131Malnutrition (HP:0004395)1.95756634
132Right ventricular cardiomyopathy (HP:0011663)1.92312137
133Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.90218613
134Abnormal trabecular bone morphology (HP:0100671)1.90103279
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89936269
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.89936269
137Distal lower limb amyotrophy (HP:0008944)1.89807601
138Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.88159087
139Asymmetry of the thorax (HP:0001555)1.87375075
140Bradycardia (HP:0001662)1.86977204
141Nail dystrophy (HP:0008404)1.85645131
142Heterochromia iridis (HP:0001100)1.85475464
143Myelomeningocele (HP:0002475)1.85469007
144Hyperacusis (HP:0010780)1.85353480
145Male infertility (HP:0003251)1.85314895
146Progressive muscle weakness (HP:0003323)1.84711444
147Biconcave vertebral bodies (HP:0004586)1.84708511
148Spastic diplegia (HP:0001264)1.84593707
149Deep venous thrombosis (HP:0002625)1.84502274
150Short humerus (HP:0005792)1.84316390
151Absent eyelashes (HP:0000561)1.84115973
152Tibial bowing (HP:0002982)1.83813138
153Pterygium (HP:0001059)1.83695163
154Chorioretinal atrophy (HP:0000533)1.83673109
155Abnormality of vitamin metabolism (HP:0100508)1.83275706
156Increased muscle lipid content (HP:0009058)1.82877573
157Keratoconus (HP:0000563)1.81681558
158Increased corneal curvature (HP:0100692)1.81681558
159Thrombocytosis (HP:0001894)1.81258094
160Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79996788
161Stenosis of the external auditory canal (HP:0000402)1.79992949
162Abnormal atrioventricular conduction (HP:0005150)1.79762835
163Easy fatigability (HP:0003388)1.78225948
164Purpura (HP:0000979)1.77962811
165Increased intramyocellular lipid droplets (HP:0012240)1.77938748
166Malignant hyperthermia (HP:0002047)1.77000399
167Germ cell neoplasia (HP:0100728)1.76944402
168Menorrhagia (HP:0000132)1.75349453
169Ragged-red muscle fibers (HP:0003200)1.74380315
170Short 5th finger (HP:0009237)1.73184175
171Premature ovarian failure (HP:0008209)1.72500676
172Abnormal blistering of the skin (HP:0008066)1.72219725
173Short chin (HP:0000331)1.71863723
174Congenital ichthyosiform erythroderma (HP:0007431)1.71826205
175Mask-like facies (HP:0000298)1.71467780
176Oral leukoplakia (HP:0002745)1.70389687
177Protruding tongue (HP:0010808)1.69348189
178Pili torti (HP:0003777)1.68775357
179Increased number of teeth (HP:0011069)1.68651673
180Congenital stationary night blindness (HP:0007642)1.68299154
181Abnormality of glutamine family amino acid metabolism (HP:0010902)1.67886848
182Abnormality of cochlea (HP:0000375)1.67858001
183Complete atrioventricular canal defect (HP:0001674)1.67664896
184Epistaxis (HP:0000421)1.67208155
185Depressed nasal ridge (HP:0000457)1.66723970
186Abnormality of the phalanges of the 5th finger (HP:0004213)1.66487559
187Abnormal gallbladder morphology (HP:0012437)1.66343793
188Xanthomatosis (HP:0000991)1.64933432
189Dysostosis multiplex (HP:0000943)1.64810469
190Abnormality of proline metabolism (HP:0010907)1.64545041
191Hydroxyprolinuria (HP:0003080)1.64545041
192Poor head control (HP:0002421)1.63622620
193Corneal erosion (HP:0200020)1.63482013
194Flat acetabular roof (HP:0003180)1.63458043

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.98463859
2EPHA26.72849287
3TSSK64.48950616
4MST43.50754854
5WNK43.40390398
6SIK13.31500581
7RPS6KB22.87776288
8MUSK2.83882670
9VRK12.70286386
10MAP3K112.52356433
11SMG12.44167193
12LRRK22.36201639
13MAP3K32.19649613
14ICK2.18256584
15ERN12.12558344
16IRAK32.07593377
17NME22.05716954
18PIM22.01964072
19NEK22.00725669
20PKN21.84128037
21STK161.77423341
22BUB11.75928991
23GRK61.73173587
24MAP3K71.68726839
25ZAK1.67204782
26EPHB11.64808109
27MARK21.63814321
28WEE11.61168834
29TGFBR11.57238695
30TESK21.56799422
31MATK1.51847123
32LATS11.50936494
33PRKD31.49896381
34PASK1.46685664
35CDK121.44621940
36PDPK11.35923775
37TLK11.32781838
38BLK1.31215909
39MAP2K61.29696477
40YES11.28779032
41WNK11.28302378
42FGFR41.25688813
43MET1.23268749
44AKT31.20188042
45MAP3K121.19195573
46PRKD21.15755113
47NTRK21.15494135
48RIPK11.15261356
49ARAF1.14699784
50IRAK21.13843490
51MAP3K21.12629355
52GRK11.12578492
53STK101.09906551
54DYRK31.07217559
55KDR1.07048528
56PAK21.04571422
57NTRK11.02872411
58MTOR1.02012109
59JAK21.00250677
60RPS6KA20.99337571
61PAK40.97847758
62MAP3K140.95835210
63TAOK20.95447549
64CDK190.93799179
65PDGFRA0.92578971
66NME10.92294949
67MAP2K20.89054583
68CDK60.89009081
69PTK60.86848051
70TTK0.84561659
71SCYL20.83706843
72RIPK40.81784168
73BMX0.81760192
74KIT0.80057269
75PTK20.78709421
76MAP2K30.75484462
77TBK10.75371476
78MAPKAPK30.75154293
79CAMK10.74449464
80MST1R0.74291671
81CAMK1D0.73981674
82ZAP700.72956536
83MAPK40.71096001
84BRSK20.70631303
85MAP3K80.69470145
86MAP3K10.68824506
87EIF2AK20.67704107
88BRSK10.66305709
89PAK30.65479967
90MAP3K60.64951016
91ILK0.64723551
92CDK70.64211849
93BRAF0.63621850
94AURKA0.62305996
95PIM10.61850517
96EEF2K0.59786446
97MAPK110.58933975
98CDK40.58872644
99RPS6KL10.58581550
100RPS6KC10.58581550
101SIK20.57216346
102ALK0.56213881
103DYRK1B0.55889697
104PRKCH0.54082632
105PRKCD0.52111060
106MAP2K70.51414683
107PLK30.50862612
108RAF10.49539675
109EIF2AK10.48219374
110RPS6KA60.47506559
111CSNK1E0.46979392
112CDK150.46470642
113MAP3K130.45682839
114MAPKAPK50.45273104
115BTK0.45048603
116NEK60.44683208
117FER0.44633603
118TAOK10.44364174
119PRKD10.44127965
120CDK80.43550451
121MAP2K10.43394652
122TEC0.43065619
123CDK11A0.42916527
124PAK10.41600545
125CHEK20.40565055
126STK390.40416179
127ABL10.40208224
128DDR20.40024337
129CDK180.39877500
130ATR0.39670352
131MAPK80.39582480
132ROCK20.39511012
133SRC0.38177885
134MELK0.37788824
135PRKCI0.37316013
136DAPK30.36717444
137MAP3K90.36122008
138CDC42BPA0.35313288
139TESK10.34337716
140AURKB0.34241582
141FLT30.34124214
142TTN0.33669029
143LATS20.33394765
144MAPKAPK20.33308872
145MAP2K40.33059448
146CSNK2A20.33023554
147HIPK20.32822932
148CCNB10.31158809
149MAPK120.30989548
150EGFR0.30570621
151TYRO30.30498597
152CSNK1G30.29927886
153PRKCA0.29386274
154STK380.29293448
155MAPK90.28791998
156PDK10.28363324
157TRIB30.27966933
158MAP3K50.27717189
159AKT20.26215276
160CAMK1G0.25803901
161NTRK30.25112110
162PLK10.24391771
163ERBB40.24257808
164CAMK2A0.22201853

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030108.80114493
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.90162217
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006044.24352078
4RNA polymerase_Homo sapiens_hsa030203.42641521
5Other glycan degradation_Homo sapiens_hsa005113.13050980
6Fructose and mannose metabolism_Homo sapiens_hsa000512.98112437
7Arginine biosynthesis_Homo sapiens_hsa002202.82410195
8Asthma_Homo sapiens_hsa053102.76285964
9Sphingolipid metabolism_Homo sapiens_hsa006002.40734053
10Nitrogen metabolism_Homo sapiens_hsa009102.33675413
11One carbon pool by folate_Homo sapiens_hsa006702.30169478
12DNA replication_Homo sapiens_hsa030302.16962740
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.11811952
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10577915
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05127953
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02380228
17Sulfur relay system_Homo sapiens_hsa041221.88905243
18Folate biosynthesis_Homo sapiens_hsa007901.88431260
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60087855
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.57263364
21Systemic lupus erythematosus_Homo sapiens_hsa053221.57102236
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53029021
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51249011
24mTOR signaling pathway_Homo sapiens_hsa041501.51058168
25Hematopoietic cell lineage_Homo sapiens_hsa046401.47146897
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40817137
27VEGF signaling pathway_Homo sapiens_hsa043701.38233522
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.35877170
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.35782612
30Small cell lung cancer_Homo sapiens_hsa052221.35759701
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35508751
32Pentose phosphate pathway_Homo sapiens_hsa000301.32141571
33Vitamin digestion and absorption_Homo sapiens_hsa049771.31550507
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28945339
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.26980797
36Biosynthesis of amino acids_Homo sapiens_hsa012301.26466710
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22852903
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22219673
39ECM-receptor interaction_Homo sapiens_hsa045121.20886503
40Vitamin B6 metabolism_Homo sapiens_hsa007501.20765486
41N-Glycan biosynthesis_Homo sapiens_hsa005101.19132919
42Alcoholism_Homo sapiens_hsa050341.18837988
43Inositol phosphate metabolism_Homo sapiens_hsa005621.18800590
44Pyrimidine metabolism_Homo sapiens_hsa002401.17953287
45Phenylalanine metabolism_Homo sapiens_hsa003601.17532216
46Lysosome_Homo sapiens_hsa041421.16058660
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11355580
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11284924
49Lysine degradation_Homo sapiens_hsa003101.10423193
50p53 signaling pathway_Homo sapiens_hsa041151.10277294
51Phototransduction_Homo sapiens_hsa047441.07385365
52Notch signaling pathway_Homo sapiens_hsa043301.06090316
53Histidine metabolism_Homo sapiens_hsa003401.05475710
54Renin-angiotensin system_Homo sapiens_hsa046141.03867380
55Non-small cell lung cancer_Homo sapiens_hsa052231.02973269
56Carbon metabolism_Homo sapiens_hsa012001.00037504
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.97632844
58Proteasome_Homo sapiens_hsa030500.94411856
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94291518
60Linoleic acid metabolism_Homo sapiens_hsa005910.91918495
61Platelet activation_Homo sapiens_hsa046110.91195524
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87881288
63Glutathione metabolism_Homo sapiens_hsa004800.86915544
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86052979
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83958033
66Tryptophan metabolism_Homo sapiens_hsa003800.81229867
67Legionellosis_Homo sapiens_hsa051340.81145258
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80155103
69Endometrial cancer_Homo sapiens_hsa052130.78360618
70Insulin resistance_Homo sapiens_hsa049310.77291863
71Base excision repair_Homo sapiens_hsa034100.76745844
72Fatty acid biosynthesis_Homo sapiens_hsa000610.76309832
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75937517
74Hepatitis C_Homo sapiens_hsa051600.75791189
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73888364
76ABC transporters_Homo sapiens_hsa020100.73565922
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.73485362
78Acute myeloid leukemia_Homo sapiens_hsa052210.73301838
79Antigen processing and presentation_Homo sapiens_hsa046120.71030303
80Fatty acid degradation_Homo sapiens_hsa000710.70519498
81Amoebiasis_Homo sapiens_hsa051460.69569837
82Fatty acid metabolism_Homo sapiens_hsa012120.68810585
83Galactose metabolism_Homo sapiens_hsa000520.67468273
84Pyruvate metabolism_Homo sapiens_hsa006200.67127407
85Fat digestion and absorption_Homo sapiens_hsa049750.66974217
86Tyrosine metabolism_Homo sapiens_hsa003500.66661427
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66626980
88Thyroid cancer_Homo sapiens_hsa052160.65867190
89AMPK signaling pathway_Homo sapiens_hsa041520.63661312
90Insulin signaling pathway_Homo sapiens_hsa049100.63636217
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63277054
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.62931355
93Purine metabolism_Homo sapiens_hsa002300.62929495
94Bile secretion_Homo sapiens_hsa049760.62004623
95Hippo signaling pathway_Homo sapiens_hsa043900.61333015
96Bladder cancer_Homo sapiens_hsa052190.61020829
97Endocytosis_Homo sapiens_hsa041440.61002224
98Basal cell carcinoma_Homo sapiens_hsa052170.60567241
99Viral carcinogenesis_Homo sapiens_hsa052030.60251999
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60056796
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59097939
102Circadian rhythm_Homo sapiens_hsa047100.58765653
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.58611942
104Spliceosome_Homo sapiens_hsa030400.58226564
105Fatty acid elongation_Homo sapiens_hsa000620.57678042
106Nucleotide excision repair_Homo sapiens_hsa034200.53589753
107PPAR signaling pathway_Homo sapiens_hsa033200.52974569
108Apoptosis_Homo sapiens_hsa042100.52079273
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51378415
110Arachidonic acid metabolism_Homo sapiens_hsa005900.51148228
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51025107
112Ether lipid metabolism_Homo sapiens_hsa005650.50734880
113RNA transport_Homo sapiens_hsa030130.50383892
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.50376701
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47612689
116Melanogenesis_Homo sapiens_hsa049160.45002541
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.44396527
118Long-term depression_Homo sapiens_hsa047300.44181003
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44075105
120Pancreatic cancer_Homo sapiens_hsa052120.44053397
121Proteoglycans in cancer_Homo sapiens_hsa052050.43815208
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42803218
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42675718
124Ovarian steroidogenesis_Homo sapiens_hsa049130.40500743
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39788174
126Glucagon signaling pathway_Homo sapiens_hsa049220.39501894
127Axon guidance_Homo sapiens_hsa043600.38361384
128Toxoplasmosis_Homo sapiens_hsa051450.38278578
129TNF signaling pathway_Homo sapiens_hsa046680.38173166
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37593766
131Focal adhesion_Homo sapiens_hsa045100.36843063
132African trypanosomiasis_Homo sapiens_hsa051430.35706063
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34660901
134Fanconi anemia pathway_Homo sapiens_hsa034600.33354854
135Pathways in cancer_Homo sapiens_hsa052000.32610178
136Prostate cancer_Homo sapiens_hsa052150.31729295
137Dilated cardiomyopathy_Homo sapiens_hsa054140.31419877
138Mismatch repair_Homo sapiens_hsa034300.30956364
139Chronic myeloid leukemia_Homo sapiens_hsa052200.30773240
140Salmonella infection_Homo sapiens_hsa051320.30590926
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30486455
142Hedgehog signaling pathway_Homo sapiens_hsa043400.30333843
143Chemical carcinogenesis_Homo sapiens_hsa052040.29011372
144Olfactory transduction_Homo sapiens_hsa047400.28895311
145Leukocyte transendothelial migration_Homo sapiens_hsa046700.28821956
146ErbB signaling pathway_Homo sapiens_hsa040120.27971621
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27870014
148Gastric acid secretion_Homo sapiens_hsa049710.27072974
149Glioma_Homo sapiens_hsa052140.26746414
150Maturity onset diabetes of the young_Homo sapiens_hsa049500.26196046
151Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26111204
152PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25183625
153Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.24629099
154Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24129163
155Choline metabolism in cancer_Homo sapiens_hsa052310.24099637
156Tight junction_Homo sapiens_hsa045300.24033070
157GnRH signaling pathway_Homo sapiens_hsa049120.24013142
158Steroid hormone biosynthesis_Homo sapiens_hsa001400.23178715
159Steroid biosynthesis_Homo sapiens_hsa001000.22703185
160Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21934871
161Metabolic pathways_Homo sapiens_hsa011000.21776909
162Sphingolipid signaling pathway_Homo sapiens_hsa040710.21636684
163Estrogen signaling pathway_Homo sapiens_hsa049150.21636649
164Arginine and proline metabolism_Homo sapiens_hsa003300.21156743
165Malaria_Homo sapiens_hsa051440.21070580

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