RNF225

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell aging (GO:0090344)9.91714400
2GDP-mannose metabolic process (GO:0019673)9.46466955
3adenosine receptor signaling pathway (GO:0001973)8.94991567
4proline biosynthetic process (GO:0006561)8.83287645
5G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)8.29580539
6adenine nucleotide transport (GO:0051503)7.98972031
7rRNA methylation (GO:0031167)7.76909036
8purinergic nucleotide receptor signaling pathway (GO:0035590)7.74095471
9purine ribonucleotide transport (GO:0015868)7.72920424
10regulation of skeletal muscle contraction (GO:0014819)7.55878305
11embryonic process involved in female pregnancy (GO:0060136)7.14576398
12lens fiber cell differentiation (GO:0070306)7.09926210
13proline metabolic process (GO:0006560)6.96888629
14positive regulation of protein kinase C signaling (GO:0090037)6.93018938
15rRNA modification (GO:0000154)6.66934062
16nucleotide transmembrane transport (GO:1901679)6.42869715
17nucleoside transmembrane transport (GO:1901642)6.36454031
18purine nucleotide transport (GO:0015865)6.26002298
19replication fork processing (GO:0031297)6.23481869
20regulation of synapse structural plasticity (GO:0051823)6.19903364
21response to ATP (GO:0033198)6.17408855
22regulation of integrin activation (GO:0033623)6.17227154
23establishment of apical/basal cell polarity (GO:0035089)6.07736351
24sensory perception of taste (GO:0050909)6.05939120
25positive regulation of protein homooligomerization (GO:0032464)5.96639324
26peptidyl-glutamic acid carboxylation (GO:0017187)5.72084687
27protein carboxylation (GO:0018214)5.72084687
28transcription from mitochondrial promoter (GO:0006390)5.69937880
29DNA deamination (GO:0045006)5.65467743
30urinary tract smooth muscle contraction (GO:0014848)5.60220200
31purinergic receptor signaling pathway (GO:0035587)5.59865593
32keratinization (GO:0031424)5.50788366
33melanin biosynthetic process (GO:0042438)5.49887316
34oxidative demethylation (GO:0070989)5.40525576
35maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.32016144
36regulation of gene silencing by RNA (GO:0060966)5.30087793
37regulation of posttranscriptional gene silencing (GO:0060147)5.30087793
38regulation of gene silencing by miRNA (GO:0060964)5.30087793
39embryonic placenta development (GO:0001892)5.20998080
40UV protection (GO:0009650)5.19634593
41DNA replication-dependent nucleosome organization (GO:0034723)5.18020161
42DNA replication-dependent nucleosome assembly (GO:0006335)5.18020161
43peristalsis (GO:0030432)5.16632390
44behavioral response to nicotine (GO:0035095)5.14265792
45establishment of monopolar cell polarity (GO:0061162)5.13050736
46establishment or maintenance of monopolar cell polarity (GO:0061339)5.13050736
47regulation of protein homooligomerization (GO:0032462)5.10898880
48sex determination (GO:0007530)5.06458577
49DNA strand renaturation (GO:0000733)4.97081046
50melanin metabolic process (GO:0006582)4.93549939
51regulation of protein kinase A signaling (GO:0010738)4.90886029
52somatic hypermutation of immunoglobulin genes (GO:0016446)4.87876406
53somatic diversification of immune receptors via somatic mutation (GO:0002566)4.87876406
54G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.87428821
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.86610616
56nucleotide-sugar biosynthetic process (GO:0009226)4.84498304
57mitochondrial DNA metabolic process (GO:0032042)4.75968312
58nucleoside transport (GO:0015858)4.70770577
59purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.69221851
603-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.69221851
61negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.58130101
62regulation of cell aging (GO:0090342)4.57762292
63glutamine family amino acid biosynthetic process (GO:0009084)4.48940192
64secondary metabolite biosynthetic process (GO:0044550)4.44258888
65regulation of translational fidelity (GO:0006450)4.42904918
66regulation of cytokine production involved in inflammatory response (GO:1900015)4.42570691
67positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.36153630
68histone phosphorylation (GO:0016572)4.32584989
69DNA integration (GO:0015074)4.31914523
70establishment of skin barrier (GO:0061436)4.28926479
71gonadal mesoderm development (GO:0007506)4.25870783
72regulation of protein polyubiquitination (GO:1902914)4.24360558
73viral mRNA export from host cell nucleus (GO:0046784)4.21504166
74negative regulation of fatty acid biosynthetic process (GO:0045717)4.19328025
75DNA replication checkpoint (GO:0000076)4.16548863
76neuromuscular synaptic transmission (GO:0007274)4.13765138
77mitotic cell cycle arrest (GO:0071850)4.13038260
78mitotic G1 DNA damage checkpoint (GO:0031571)4.09203485
79transepithelial transport (GO:0070633)4.08450231
80ribonucleoside bisphosphate biosynthetic process (GO:0034030)4.03573108
81nucleoside bisphosphate biosynthetic process (GO:0033866)4.03573108
82purine nucleoside bisphosphate biosynthetic process (GO:0034033)4.03573108
83detection of light stimulus involved in visual perception (GO:0050908)3.98597281
84detection of light stimulus involved in sensory perception (GO:0050962)3.98597281
85sialylation (GO:0097503)3.97372486
86apoptotic process involved in morphogenesis (GO:0060561)3.91988820
87telomere maintenance via semi-conservative replication (GO:0032201)3.90100311
88grooming behavior (GO:0007625)3.86429409
89spliceosomal tri-snRNP complex assembly (GO:0000244)3.83762454
90positive regulation of protein oligomerization (GO:0032461)3.83575179
91positive regulation of developmental pigmentation (GO:0048087)3.83160223
92sphingomyelin metabolic process (GO:0006684)3.82714540
93negative regulation of Ras GTPase activity (GO:0034261)3.81601453
94positive regulation of catecholamine secretion (GO:0033605)3.79451176
95mitotic G1/S transition checkpoint (GO:0044819)3.78388426
96cellular response to ATP (GO:0071318)3.76306675
97positive regulation of heat generation (GO:0031652)3.71543142
98regulation of nuclear cell cycle DNA replication (GO:0033262)3.70033689
99nucleotide-excision repair, DNA gap filling (GO:0006297)3.69594404
100mRNA cleavage (GO:0006379)3.69533576
101establishment of protein localization to mitochondrial membrane (GO:0090151)3.68480617
102regulation of DNA damage checkpoint (GO:2000001)3.63706686
103poly(A)+ mRNA export from nucleus (GO:0016973)3.60889702
104regulation of water loss via skin (GO:0033561)3.59823201
105positive regulation of mitotic sister chromatid separation (GO:1901970)3.53797673
106positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.53797673
107positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.53797673
108nucleotide transport (GO:0006862)3.53346046
109cellular response to zinc ion (GO:0071294)3.53126412
110G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.52932055
111G1 DNA damage checkpoint (GO:0044783)3.52912812
112tRNA modification (GO:0006400)3.52902279
113non-recombinational repair (GO:0000726)3.48846633
114double-strand break repair via nonhomologous end joining (GO:0006303)3.48846633
115dosage compensation (GO:0007549)3.47760386
116meiotic chromosome segregation (GO:0045132)3.46177434
117sphingosine metabolic process (GO:0006670)3.45132506
118activation of adenylate cyclase activity (GO:0007190)3.44609342
119base-excision repair (GO:0006284)3.38684027
120diol metabolic process (GO:0034311)3.38133097
121estrogen biosynthetic process (GO:0006703)3.32957719
122positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.32184576
123negative regulation of tumor necrosis factor production (GO:0032720)3.27636343
124activation of Rac GTPase activity (GO:0032863)3.27241990
125negative regulation of JAK-STAT cascade (GO:0046426)3.26309402
126regulation of phospholipid biosynthetic process (GO:0071071)3.26259003
127anatomical structure regression (GO:0060033)3.26113292
128regulation of protein oligomerization (GO:0032459)3.26010936
129regulation of sister chromatid cohesion (GO:0007063)3.25255604
130phosphatidylglycerol biosynthetic process (GO:0006655)3.24251872
131negative regulation of cell cycle arrest (GO:0071157)3.23240001
132convergent extension (GO:0060026)3.22576263
133determination of adult lifespan (GO:0008340)3.22496129
134negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.21224867
135negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.19303820
136regulation of gene silencing (GO:0060968)3.17401576
137phosphate ion homeostasis (GO:0055062)3.16344716
138trivalent inorganic anion homeostasis (GO:0072506)3.16344716
139sulfur amino acid catabolic process (GO:0000098)3.16000308
140very-low-density lipoprotein particle assembly (GO:0034379)3.12988491
141cellular anion homeostasis (GO:0030002)3.12900407
142telomere maintenance via recombination (GO:0000722)3.11964361
143embryonic camera-type eye development (GO:0031076)3.11005715
144mitochondrial RNA metabolic process (GO:0000959)3.07615905
145regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.07225367
146prenylation (GO:0097354)3.03659497
147protein prenylation (GO:0018342)3.03659497
148glial cell migration (GO:0008347)3.03203005
149folic acid metabolic process (GO:0046655)3.03055020
150urogenital system development (GO:0001655)2.99771239
151negative regulation of protein oligomerization (GO:0032460)2.99059381
152DNA strand elongation involved in DNA replication (GO:0006271)2.99007056
153positive regulation of adenylate cyclase activity (GO:0045762)2.98851087
154negative regulation of interleukin-8 production (GO:0032717)2.97507656
155DNA demethylation (GO:0080111)2.96936258
156behavioral response to pain (GO:0048266)2.95890220
157positive regulation of DNA repair (GO:0045739)2.95177384
158dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.95171045
159regulation of double-strand break repair (GO:2000779)2.94047138
160apoptotic process involved in development (GO:1902742)2.93585926
161protein localization to endosome (GO:0036010)2.92410264
162keratan sulfate biosynthetic process (GO:0018146)2.90823240
163endocytic recycling (GO:0032456)2.90751298
164regulation of hydrogen peroxide metabolic process (GO:0010310)2.89524377
165iron coordination entity transport (GO:1901678)2.89488097
166histone H4-K12 acetylation (GO:0043983)2.87837019
167post-anal tail morphogenesis (GO:0036342)2.87705431
168reciprocal DNA recombination (GO:0035825)2.87213146
169reciprocal meiotic recombination (GO:0007131)2.87213146
170protein import into peroxisome matrix (GO:0016558)2.86599043
171muscle fiber development (GO:0048747)2.86038592
172DNA topological change (GO:0006265)2.85844764
173phosphate ion transmembrane transport (GO:0035435)2.82945734
174regulation of double-strand break repair via homologous recombination (GO:0010569)2.82028775
175regulation of podosome assembly (GO:0071801)2.81727561
176base-excision repair, AP site formation (GO:0006285)2.80286029
177nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.79049592
178DNA strand elongation (GO:0022616)2.78915982
179sphingoid metabolic process (GO:0046519)2.78899603
180mannose metabolic process (GO:0006013)2.78867694
181protein targeting to vacuole (GO:0006623)2.78622781
182protein targeting to lysosome (GO:0006622)2.78622781
183establishment of protein localization to vacuole (GO:0072666)2.78622781
184cardiolipin metabolic process (GO:0032048)2.78275032
185cilium or flagellum-dependent cell motility (GO:0001539)2.77373709
186negative regulation of chondrocyte differentiation (GO:0032331)2.77175143
187regulation of protein kinase C signaling (GO:0090036)2.75425486
188negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.75205526
189interferon-gamma production (GO:0032609)2.75203718
190regulation of heat generation (GO:0031650)2.74907135
191positive regulation of antigen processing and presentation (GO:0002579)2.74223769
192positive regulation of cAMP biosynthetic process (GO:0030819)2.73966131
193DNA double-strand break processing (GO:0000729)2.73605587
194DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.73555870
195face development (GO:0060324)2.71097250
196positive regulation of chromosome segregation (GO:0051984)2.70705025
197folic acid-containing compound biosynthetic process (GO:0009396)2.70686368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.28609951
2STAT6_21828071_ChIP-Seq_BEAS2B_Human5.09061699
3SMAD1_18555785_ChIP-Seq_MESCs_Mouse4.58296678
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.16871942
5E2F7_22180533_ChIP-Seq_HELA_Human3.91406257
6P68_20966046_ChIP-Seq_HELA_Human3.20536306
7TCF3_18692474_ChIP-Seq_MESCs_Mouse2.74146561
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.68817044
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.68706081
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.68360576
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.65712456
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.62774387
13XRN2_22483619_ChIP-Seq_HELA_Human2.58891693
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.58533654
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.58533654
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.58533654
17CTCF_27219007_Chip-Seq_Bcells_Human2.57280037
18MAF_26560356_Chip-Seq_TH2_Human2.49207194
19BCL6_27268052_Chip-Seq_Bcells_Human2.47771356
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.44915161
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.43147854
22E2F1_20622854_ChIP-Seq_HELA_Human2.43006483
23BCOR_27268052_Chip-Seq_Bcells_Human2.42111155
24STAT3_1855785_ChIP-Seq_MESCs_Mouse2.40652901
25SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.39690447
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.37350835
27MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.30230892
28MYC_18555785_ChIP-Seq_MESCs_Mouse2.24422965
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.23933498
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20179693
31TCF3_18692474_ChIP-Seq_MEFs_Mouse2.19847823
32PHF8_20622854_ChIP-Seq_HELA_Human2.16818801
33VDR_24763502_ChIP-Seq_THP-1_Human2.16696287
34ESR1_15608294_ChIP-ChIP_MCF-7_Human2.11935933
35SMAD2/3_21741376_ChIP-Seq_ESCs_Human2.09455463
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.09146639
37RARB_24833708_ChIP-Seq_LIVER_Mouse2.03369826
38NANOG_18555785_ChIP-Seq_MESCs_Mouse2.02986104
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.00072220
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.99751997
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.99320975
42SMC4_20622854_ChIP-Seq_HELA_Human1.97901618
43MAF_26560356_Chip-Seq_TH1_Human1.93648419
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92790114
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86978047
46RARA_24833708_ChIP-Seq_LIVER_Mouse1.84098875
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.83573828
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.81954010
49POU5F1_16518401_ChIP-PET_MESCs_Mouse1.80545552
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.80439770
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.77307687
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76939620
53FOXP1_21924763_ChIP-Seq_HESCs_Human1.76062841
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75928847
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75168728
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74996147
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72487413
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.70430859
59NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.70072983
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.69800275
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.69292322
62SOX2_18692474_ChIP-Seq_MESCs_Mouse1.69035468
63CTCF_21964334_Chip-Seq_Bcells_Human1.67185318
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.66568549
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.66391440
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66233995
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65302621
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.64480130
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63313090
70SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63203135
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.61792073
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.61699366
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60583731
74CTCF_20526341_ChIP-Seq_ESCs_Human1.59794555
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56520375
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.54613929
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50625950
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50580239
79NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.50057488
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.49908271
81KDM2B_26808549_Chip-Seq_DND41_Human1.48680636
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48652116
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48625610
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.48367701
85SA1_27219007_Chip-Seq_Bcells_Human1.46802376
86ERA_21632823_ChIP-Seq_H3396_Human1.45993800
87CTCF_21964334_ChIP-Seq_BJAB-B_Human1.45638922
88CREB1_26743006_Chip-Seq_LNCaP_Human1.44852602
89MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43576236
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42241286
91MYC_22102868_ChIP-Seq_BL_Human1.42152371
92POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.41962187
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.41889055
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.41156094
95NANOG_18692474_ChIP-Seq_MESCs_Mouse1.40881112
96RXR_22158963_ChIP-Seq_LIVER_Mouse1.40513791
97FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39965963
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39864163
99YY1_22570637_ChIP-Seq_MALME-3M_Human1.38371164
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37320118
101UTX_26944678_Chip-Seq_JUKART_Human1.36631407
102TP53_22127205_ChIP-Seq_IMR90_Human1.35512908
103P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35380133
104RXRA_24833708_ChIP-Seq_LIVER_Mouse1.35234363
105TP63_22573176_ChIP-Seq_HFKS_Human1.35113840
106JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34531629
107FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34128554
108ATF3_27146783_Chip-Seq_COLON_Human1.34100449
109TCF7_22412390_ChIP-Seq_EML_Mouse1.33835312
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.33463535
111E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31892627
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31066411
113NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.30913240
114VDR_21846776_ChIP-Seq_THP-1_Human1.30638311
115P53_21459846_ChIP-Seq_SAOS-2_Human1.29096078
116JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.29052672
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26696001
118ESR2_21235772_ChIP-Seq_MCF-7_Human1.26548800
119CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25563768
120ZNF263_19887448_ChIP-Seq_K562_Human1.25557862
121NANOG_21062744_ChIP-ChIP_HESCs_Human1.23749514
122ELK3_25401928_ChIP-Seq_HUVEC_Human1.23711339
123E2F1_21310950_ChIP-Seq_MCF-7_Human1.22562317
124SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21998737
125P300_27268052_Chip-Seq_Bcells_Human1.21704648
126KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20176302
127TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.19953274
128RUNX1_27514584_Chip-Seq_MCF-7_Human1.18224628
129FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17184041
130SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16988234
131UBF1/2_26484160_Chip-Seq_HMECs_Human1.16632531
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16188727
133PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14961871
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13451704
135CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12826874
136PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12500317
137TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12072362
138TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11849570
139SMC3_22415368_ChIP-Seq_MEFs_Mouse1.11633208
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10978837
141SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09839822
142CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08837030
143NCOR1_26117541_ChIP-Seq_K562_Human1.08209525
144PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08054622
145NANOG_20526341_ChIP-Seq_ESCs_Human1.07762041
146CTCF_26484167_Chip-Seq_Bcells_Mouse1.07170149
147TAF2_19829295_ChIP-Seq_ESCs_Human1.06873919
148LXR_22292898_ChIP-Seq_THP-1_Human1.06349083
149KAP1_27257070_Chip-Seq_ESCs_Mouse1.05688658
150NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05489834
151PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05151173
152TP63_19390658_ChIP-ChIP_HaCaT_Human1.04085860
153KDM2B_26808549_Chip-Seq_K562_Human1.04084208
154OCT4_19829295_ChIP-Seq_ESCs_Human1.03819088
155DCP1A_22483619_ChIP-Seq_HELA_Human1.02592561
156POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02591141
157RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01685500
158MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00905805
159NANOG_18692474_ChIP-Seq_MEFs_Mouse1.00130521
160POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99361513
161PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.97029737
162BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95061332
163KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94948931
164NANOG_16518401_ChIP-PET_MESCs_Mouse0.94098655
165HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93987364
166OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92530997
167TET1_21451524_ChIP-Seq_MESCs_Mouse0.90615609
168EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90066521
169TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89298988
170ERG_21242973_ChIP-ChIP_JURKAT_Human0.88025888
171ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87277915
172BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87178307
173LXR_22158963_ChIP-Seq_LIVER_Mouse0.85621889
174RACK7_27058665_Chip-Seq_MCF-7_Human0.82487294
175TTF2_22483619_ChIP-Seq_HELA_Human0.81595952
176VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80862471
177NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79754910
178ETS1_21867929_ChIP-Seq_TH2_Mouse0.79599833
179EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79452892
180PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78318086
181EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78268786
182KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77671556

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity6.76705879
2MP0005423_abnormal_somatic_nervous6.10256978
3MP0008057_abnormal_DNA_replication4.63559016
4MP0001188_hyperpigmentation4.54659660
5MP0005409_darkened_coat_color4.45053215
6MP0005171_absent_coat_pigmentation4.19115179
7MP0003136_yellow_coat_color3.70326725
8MP0005174_abnormal_tail_pigmentation3.15266358
9MP0002009_preneoplasia3.10895223
10MP0010307_abnormal_tumor_latency2.89902809
11MP0001968_abnormal_touch/_nociception2.82616143
12MP0003453_abnormal_keratinocyte_physiol2.65031942
13MP0005058_abnormal_lysosome_morphology2.62898060
14MP0003705_abnormal_hypodermis_morpholog2.47180557
15MP0005085_abnormal_gallbladder_physiolo2.37149053
16MP0002638_abnormal_pupillary_reflex2.33020122
17MP0009278_abnormal_bone_marrow2.28089630
18MP0003172_abnormal_lysosome_physiology2.27041398
19MP0000015_abnormal_ear_pigmentation2.26652183
20MP0001756_abnormal_urination2.23705064
21MP0003941_abnormal_skin_development2.20404998
22MP0010030_abnormal_orbit_morphology2.19020081
23MP0008995_early_reproductive_senescence2.18062049
24MP0010094_abnormal_chromosome_stability2.17560969
25MP0005083_abnormal_biliary_tract2.17317419
26MP0010234_abnormal_vibrissa_follicle2.04228650
27MP0002796_impaired_skin_barrier2.01885829
28MP0001502_abnormal_circadian_rhythm1.97986806
29MP0000751_myopathy1.94100969
30MP0002736_abnormal_nociception_after1.92550628
31MP0003786_premature_aging1.92132552
32MP0000579_abnormal_nail_morphology1.87097633
33MP0000371_diluted_coat_color1.86174544
34MP0005275_abnormal_skin_tensile1.83918035
35MP0006082_CNS_inflammation1.79464296
36MP0002282_abnormal_trachea_morphology1.77145262
37MP0002060_abnormal_skin_morphology1.73133871
38MP0005076_abnormal_cell_differentiation1.72550402
39MP0004233_abnormal_muscle_weight1.71939126
40MP0010352_gastrointestinal_tract_polyps1.71051380
41MP0003111_abnormal_nucleus_morphology1.70428006
42MP0003806_abnormal_nucleotide_metabolis1.67953954
43MP0008875_abnormal_xenobiotic_pharmacok1.66162347
44MP0005365_abnormal_bile_salt1.63032052
45MP0008438_abnormal_cutaneous_collagen1.59212618
46MP0004957_abnormal_blastocyst_morpholog1.58199453
47MP0004043_abnormal_pH_regulation1.51932228
48MP0000538_abnormal_urinary_bladder1.51888802
49MP0004264_abnormal_extraembryonic_tissu1.51540263
50MP0003890_abnormal_embryonic-extraembry1.47191013
51MP0004019_abnormal_vitamin_homeostasis1.42779488
52MP0000750_abnormal_muscle_regeneration1.40827087
53MP0001293_anophthalmia1.40100490
54MP0004381_abnormal_hair_follicle1.38288322
55MP0002086_abnormal_extraembryonic_tissu1.36231834
56MP0005075_abnormal_melanosome_morpholog1.35252583
57MP0010386_abnormal_urinary_bladder1.34779625
58MP0000013_abnormal_adipose_tissue1.30197385
59MP0005501_abnormal_skin_physiology1.29483190
60MP0008058_abnormal_DNA_repair1.28878426
61MP0000490_abnormal_crypts_of1.26939979
62MP0004197_abnormal_fetal_growth/weight/1.24826376
63MP0002006_tumorigenesis1.22778853
64MP0009840_abnormal_foam_cell1.22116082
65MP0002111_abnormal_tail_morphology1.19197787
66MP0002735_abnormal_chemical_nociception1.19196022
67MP0006072_abnormal_retinal_apoptosis1.15697866
68MP0001545_abnormal_hematopoietic_system1.14340047
69MP0005397_hematopoietic_system_phenotyp1.14340047
70MP0003718_maternal_effect1.13161719
71MP0002084_abnormal_developmental_patter1.12599735
72MP0001340_abnormal_eyelid_morphology1.11283103
73MP0000467_abnormal_esophagus_morphology1.10795072
74MP0003566_abnormal_cell_adhesion1.07004273
75MP0003119_abnormal_digestive_system1.06850910
76MP0004133_heterotaxia1.05695592
77MP0004130_abnormal_muscle_cell1.05200912
78MP0005332_abnormal_amino_acid1.04795070
79MP0002166_altered_tumor_susceptibility1.01512574
80MP0002085_abnormal_embryonic_tissue0.99412004
81MP0001324_abnormal_eye_pigmentation0.97638527
82MP0001216_abnormal_epidermal_layer0.97368805
83MP0001765_abnormal_ion_homeostasis0.95051888
84MP0002019_abnormal_tumor_incidence0.94066210
85MP0001661_extended_life_span0.93828772
86MP0002075_abnormal_coat/hair_pigmentati0.93743618
87MP0005084_abnormal_gallbladder_morpholo0.93588240
88MP0005584_abnormal_enzyme/coenzyme_acti0.93161945
89MP0004185_abnormal_adipocyte_glucose0.92938857
90MP0000003_abnormal_adipose_tissue0.92705261
91MP0003283_abnormal_digestive_organ0.92584478
92MP0009931_abnormal_skin_appearance0.92401792
93MP0002249_abnormal_larynx_morphology0.92074943
94MP0003828_pulmonary_edema0.89753553
95MP0001664_abnormal_digestion0.89642667
96MP0001672_abnormal_embryogenesis/_devel0.89517166
97MP0005380_embryogenesis_phenotype0.89517166
98MP0003448_altered_tumor_morphology0.89498606
99MP0003077_abnormal_cell_cycle0.88885884
100MP0001697_abnormal_embryo_size0.88588132
101MP0003878_abnormal_ear_physiology0.88309191
102MP0005377_hearing/vestibular/ear_phenot0.88309191
103MP0008932_abnormal_embryonic_tissue0.87619669
104MP0005551_abnormal_eye_electrophysiolog0.86999493
105MP0003693_abnormal_embryo_hatching0.86058708
106MP0005330_cardiomyopathy0.85803188
107MP0001958_emphysema0.85709370
108MP0005647_abnormal_sex_gland0.85701764
109MP0000470_abnormal_stomach_morphology0.82445495
110MP0002160_abnormal_reproductive_system0.80701284
111MP0010771_integument_phenotype0.79426072
112MP0010678_abnormal_skin_adnexa0.76125739
113MP0002269_muscular_atrophy0.75695674
114MP0001145_abnormal_male_reproductive0.75292619
115MP0000762_abnormal_tongue_morphology0.74880991
116MP0001186_pigmentation_phenotype0.73919862
117MP0002098_abnormal_vibrissa_morphology0.73428490
118MP0003045_fibrosis0.72362742
119MP0000432_abnormal_head_morphology0.71658487
120MP0000609_abnormal_liver_physiology0.70724431
121MP0000477_abnormal_intestine_morphology0.70349956
122MP0002095_abnormal_skin_pigmentation0.69511891
123MP0000516_abnormal_urinary_system0.67527827
124MP0005367_renal/urinary_system_phenotyp0.67527827
125MP0001849_ear_inflammation0.66200326
126MP0003755_abnormal_palate_morphology0.66194182
127MP0003935_abnormal_craniofacial_develop0.66098612
128MP0000367_abnormal_coat/_hair0.65592709
129MP0002697_abnormal_eye_size0.64747543
130MP0000747_muscle_weakness0.64567339
131MP0000350_abnormal_cell_proliferation0.61580886
132MP0005023_abnormal_wound_healing0.60979910
133MP0002092_abnormal_eye_morphology0.60888361
134MP0002909_abnormal_adrenal_gland0.60626194
135MP0002080_prenatal_lethality0.60373164
136MP0002088_abnormal_embryonic_growth/wei0.59177051
137MP0005248_abnormal_Harderian_gland0.58911403
138MP0001905_abnormal_dopamine_level0.58463610
139MP0005410_abnormal_fertilization0.57031641
140MP0000377_abnormal_hair_follicle0.56686548
141MP0001191_abnormal_skin_condition0.56391034
142MP0003137_abnormal_impulse_conducting0.54883570
143MP0000427_abnormal_hair_cycle0.53851356
144MP0001970_abnormal_pain_threshold0.53453903
145MP0003011_delayed_dark_adaptation0.53180246
146MP0000358_abnormal_cell_content/0.52451668
147MP0004782_abnormal_surfactant_physiolog0.51484364
148MP0009643_abnormal_urine_homeostasis0.48863726
149MP0001873_stomach_inflammation0.48174527
150MP0002254_reproductive_system_inflammat0.45783778
151MP0002136_abnormal_kidney_physiology0.44607064
152MP0003091_abnormal_cell_migration0.44306369
153MP0005257_abnormal_intraocular_pressure0.40954435
154MP0002177_abnormal_outer_ear0.38818373
155MP0005220_abnormal_exocrine_pancreas0.37554683
156MP0005375_adipose_tissue_phenotype0.33738385
157MP0002933_joint_inflammation0.32607103
158MP0004947_skin_inflammation0.32088991
159MP0003632_abnormal_nervous_system0.31694764
160MP0000678_abnormal_parathyroid_gland0.30589117
161MP0004215_abnormal_myocardial_fiber0.30118614
162MP0001919_abnormal_reproductive_system0.27553593
163MP0001784_abnormal_fluid_regulation0.26735511
164MP0009053_abnormal_anal_canal0.26056328
165MP0006276_abnormal_autonomic_nervous0.24385307
166MP0002928_abnormal_bile_duct0.24153796

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)5.98948821
2Abnormal hemoglobin (HP:0011902)5.10599387
3Thin bony cortex (HP:0002753)5.10220288
4Congenital stationary night blindness (HP:0007642)5.06655208
5Attenuation of retinal blood vessels (HP:0007843)5.04845299
6Tongue fasciculations (HP:0001308)4.39538746
7Alopecia of scalp (HP:0002293)4.36449323
8Pustule (HP:0200039)4.36267322
9Dyschromatopsia (HP:0007641)4.34205565
10Rib fusion (HP:0000902)4.32248103
11Abnormality of the intrinsic pathway (HP:0010989)4.22693124
12Akinesia (HP:0002304)4.18981588
13Turricephaly (HP:0000262)4.05538022
14Chorioretinal atrophy (HP:0000533)4.03690014
15Aplasia of the musculature (HP:0100854)3.91658256
16Muscle fibrillation (HP:0010546)3.90173236
17Anteriorly placed anus (HP:0001545)3.89163207
18Concave nail (HP:0001598)3.82757223
19Rectal fistula (HP:0100590)3.79648663
20Rectovaginal fistula (HP:0000143)3.79648663
21Abnormality of placental membranes (HP:0011409)3.79277703
22Amniotic constriction ring (HP:0009775)3.79277703
23Poikiloderma (HP:0001029)3.77961574
24Facial hemangioma (HP:0000329)3.76700371
25Bony spicule pigmentary retinopathy (HP:0007737)3.74990495
26Fetal akinesia sequence (HP:0001989)3.74633405
27Facial diplegia (HP:0001349)3.74348554
28Increased IgM level (HP:0003496)3.62838291
29Hypochromic microcytic anemia (HP:0004840)3.59945539
30Ulnar bowing (HP:0003031)3.59745641
31Vaginal fistula (HP:0004320)3.58622276
32Urinary glycosaminoglycan excretion (HP:0003541)3.57461813
33Mucopolysacchariduria (HP:0008155)3.57461813
34Delayed epiphyseal ossification (HP:0002663)3.54596509
35Short humerus (HP:0005792)3.48956723
36Intestinal fistula (HP:0100819)3.48082729
37Orthostatic hypotension (HP:0001278)3.39716170
38Patellar aplasia (HP:0006443)3.38638289
39Abnormality of the costochondral junction (HP:0000919)3.38506811
40Aplasia/hypoplasia of the humerus (HP:0006507)3.32556211
41Abnormality of mucopolysaccharide metabolism (HP:0011020)3.25095630
42Abnormality of polysaccharide metabolism (HP:0011012)3.25095630
43Abnormality of glycosaminoglycan metabolism (HP:0004371)3.25095630
44Hypotrichosis (HP:0001006)3.22824908
45Prolonged partial thromboplastin time (HP:0003645)3.19966655
46Dysostosis multiplex (HP:0000943)3.19763006
47Abnormality of nail color (HP:0100643)3.18982295
48Aplasia/Hypoplasia of the patella (HP:0006498)3.13411120
49Enlarged epiphyses (HP:0010580)3.04525768
50Coronal craniosynostosis (HP:0004440)3.02945304
51Abnormality of the labia minora (HP:0012880)3.00009436
52Myocardial infarction (HP:0001658)2.97914806
53Abnormal albumin level (HP:0012116)2.97333488
54Hypoalbuminemia (HP:0003073)2.97333488
55Annular pancreas (HP:0001734)2.94695533
56Absent radius (HP:0003974)2.94218751
57Birth length less than 3rd percentile (HP:0003561)2.86608926
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.85738953
59Hemorrhage of the eye (HP:0011885)2.84181206
60Choanal stenosis (HP:0000452)2.82670842
61Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.82010108
62Vertebral hypoplasia (HP:0008417)2.82010108
63Abnormality of male internal genitalia (HP:0000022)2.80976230
64Albinism (HP:0001022)2.79052668
65Cerebral aneurysm (HP:0004944)2.77990195
66Atrioventricular block (HP:0001678)2.74465784
67Hypophosphatemic rickets (HP:0004912)2.72118518
68Selective tooth agenesis (HP:0001592)2.70700740
69Absent thumb (HP:0009777)2.70039750
70Short chin (HP:0000331)2.69181940
71Widely patent fontanelles and sutures (HP:0004492)2.68553358
72Aplasia involving forearm bones (HP:0009822)2.68039927
73Absent forearm bone (HP:0003953)2.68039927
74Narrow nasal bridge (HP:0000446)2.65146668
75Dysautonomia (HP:0002459)2.61829024
76Squamous cell carcinoma (HP:0002860)2.61013755
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.56553998
78Alacrima (HP:0000522)2.56468907
79Mesangial abnormality (HP:0001966)2.54070202
80Choroideremia (HP:0001139)2.53939862
81Clumsiness (HP:0002312)2.50643753
82Increased number of teeth (HP:0011069)2.50597845
83Cheilitis (HP:0100825)2.50240701
84Myotonia (HP:0002486)2.50173465
85Flat occiput (HP:0005469)2.49386648
86Pendular nystagmus (HP:0012043)2.42951311
87Palmar hyperkeratosis (HP:0010765)2.42012094
88Vertebral fusion (HP:0002948)2.40331803
89Pterygium (HP:0001059)2.39279027
90Lower limb hyperreflexia (HP:0002395)2.38929237
91Decreased circulating renin level (HP:0003351)2.36069092
92Reduced antithrombin III activity (HP:0001976)2.34899754
93Palmoplantar hyperkeratosis (HP:0000972)2.33614563
94Malignant hyperthermia (HP:0002047)2.32763350
95Breast hypoplasia (HP:0003187)2.32461470
96Bifid uvula (HP:0000193)2.32283468
97Basal cell carcinoma (HP:0002671)2.29599925
98Aplasia/Hypoplasia involving the musculature (HP:0001460)2.28889053
99Polydipsia (HP:0001959)2.28817480
100Abnormal drinking behavior (HP:0030082)2.28817480
101Intestinal atresia (HP:0011100)2.28177056
102Increased CSF protein (HP:0002922)2.25587283
103Decreased central vision (HP:0007663)2.25118148
104Agnosia (HP:0010524)2.24617321
105Pancreatic islet-cell hyperplasia (HP:0004510)2.23951823
106Premature graying of hair (HP:0002216)2.22043636
107Congenital hip dislocation (HP:0001374)2.19490436
108Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19091183
109Renal Fanconi syndrome (HP:0001994)2.18980241
110Complement deficiency (HP:0004431)2.17501087
111Abnormality of the hepatic vasculature (HP:0006707)2.17454832
112Capillary hemangiomas (HP:0005306)2.14865927
113Neonatal respiratory distress (HP:0002643)2.14457536
114Hamartoma (HP:0010566)2.14235254
115Neonatal onset (HP:0003623)2.13802531
116Male infertility (HP:0003251)2.13427649
117Intrahepatic cholestasis (HP:0001406)2.10197931
118Abnormality of complement system (HP:0005339)2.09829634
119Hemivertebrae (HP:0002937)2.09202135
120Hypokinesia (HP:0002375)2.09155788
121Menorrhagia (HP:0000132)2.06982785
122Myopathic facies (HP:0002058)2.06096565
123Joint stiffness (HP:0001387)2.03887319
124Abnormal epiphyseal ossification (HP:0010656)2.03005645
125Thin ribs (HP:0000883)2.02628824
126Decreased lacrimation (HP:0000633)2.02514313
127Fatigable weakness (HP:0003473)2.01549402
128Abnormality of the neuromuscular junction (HP:0003398)2.01549402
129Hyperinsulinemic hypoglycemia (HP:0000825)2.00949048
130Tubular atrophy (HP:0000092)2.00912018
131Diminished movement (HP:0002374)2.00495399
132Spinal muscular atrophy (HP:0007269)2.00041402
133Abnormality of the ischium (HP:0003174)1.98563763
134Abnormality of pyrimidine metabolism (HP:0004353)1.98324044
135Zonular cataract (HP:0010920)1.98181106
136Hypotelorism (HP:0000601)1.98126983
137Broad alveolar ridges (HP:0000187)1.97918977
138Hypoplastic ischia (HP:0003175)1.97305485
139Median cleft lip (HP:0000161)1.96315726
140Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95867736
141Hypoplasia of the pons (HP:0012110)1.95822352
142Duplicated collecting system (HP:0000081)1.95574933
143Type 2 muscle fiber atrophy (HP:0003554)1.94919916
144Upper motor neuron abnormality (HP:0002127)1.94050829
145Prostate neoplasm (HP:0100787)1.93793653
146Cystic hygroma (HP:0000476)1.93792142
147Hypochromic anemia (HP:0001931)1.91232236
148Recurrent gram-negative bacterial infections (HP:0005420)1.89590323
149Hypoplasia of the radius (HP:0002984)1.89007914
150Small hand (HP:0200055)1.88728872
151Abnormality of the periventricular white matter (HP:0002518)1.88711853
152Bowed forearm bones (HP:0003956)1.87786147
153Bowing of the arm (HP:0006488)1.87786147
154Lipid accumulation in hepatocytes (HP:0006561)1.87005887
155Hypoplasia of the ulna (HP:0003022)1.86903171
156Increased hepatocellular lipid droplets (HP:0006565)1.85773322
157Plantar hyperkeratosis (HP:0007556)1.85284214
158Joint hemorrhage (HP:0005261)1.83817182
159Premature skin wrinkling (HP:0100678)1.82997142
160Astrocytoma (HP:0009592)1.81498799
161Abnormality of the astrocytes (HP:0100707)1.81498799
162Heterotopia (HP:0002282)1.81214480
163Gangrene (HP:0100758)1.80355982
164Neoplasm of the oral cavity (HP:0100649)1.79259369
165Muscle fiber atrophy (HP:0100295)1.78812761
166Impulsivity (HP:0100710)1.77987314
167IgA deficiency (HP:0002720)1.76162122
168Vacuolated lymphocytes (HP:0001922)1.75300238
169Peripheral demyelination (HP:0011096)1.74953571
170Popliteal pterygium (HP:0009756)1.73972485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.60268700
2WNK45.44331947
3DDR24.38913019
4BLK4.18322582
5ICK4.17658463
6ZAK3.73922987
7MAP3K63.40049187
8MAPK153.36255851
9MUSK3.19296346
10MAP3K113.12413095
11GRK63.07784692
12TESK22.83786421
13EPHA22.71690581
14FGR2.63633395
15MATK2.51981400
16STK162.41874809
17PINK12.23003075
18ACVR1B2.19919586
19TYRO32.15307467
20YES12.12546862
21PHKG12.02735239
22PHKG22.02735239
23AKT31.94964570
24PIM11.87440581
25CSK1.85105887
26PDGFRA1.83392775
27BMX1.80409709
28WNK11.73812232
29WEE11.65869055
30ADRBK11.64967274
31DYRK1B1.62496229
32IRAK21.59105262
33DAPK11.56502709
34SIK21.54043558
35CDK61.52193917
36CDK71.50898204
37TRIB31.47759394
38ERN11.44394137
39TRPM71.41048860
40MST1R1.39874811
41PIM21.35009440
42BMPR1B1.34192898
43CDK121.29752772
44CCNB11.25685011
45ZAP701.23856917
46GSK3A1.21514681
47PRKD21.19770662
48ADRBK21.15741290
49VRK11.12970938
50UHMK11.11788346
51EEF2K1.09985054
52MAP2K31.09814076
53FLT31.09784913
54MAP2K61.06213383
55TGFBR11.05348997
56CDK151.01566599
57PDPK10.99915300
58MAPK110.96143369
59CDK180.95124404
60SRPK10.93922345
61CDK11A0.93764881
62MKNK20.91495372
63CHEK20.91124421
64ERBB40.89590729
65RPS6KC10.88631866
66RPS6KL10.88631866
67STK390.88470367
68SCYL20.85747530
69DYRK30.82834003
70DAPK20.82022612
71MAP3K30.81375791
72RPS6KA20.79367341
73PKN10.78717433
74SGK2230.75472752
75SGK4940.75472752
76STK40.73528484
77MELK0.71491727
78PLK10.71332090
79TBK10.70807821
80RPS6KA60.69181408
81PRKD10.69016719
82CDK90.68722833
83RPS6KB20.68029948
84RPS6KA50.66694451
85MAPK120.66571063
86RIPK10.65940065
87PKN20.65801040
88MAPKAPK30.65084879
89CDK140.65050935
90MAP3K90.63698149
91PRKD30.59730253
92STK110.59480384
93CDC42BPA0.58758605
94CAMK1D0.58437610
95LATS20.58252173
96STK30.54903177
97JAK20.51854725
98TGFBR20.51347720
99MAPK80.50363057
100EGFR0.50347281
101ARAF0.47848551
102AURKA0.46774883
103TAOK20.45953142
104NEK20.45307070
105RAF10.45176149
106PRKAA10.44810793
107LYN0.44691658
108ATR0.43666769
109IKBKB0.42941292
110PBK0.41318824
111SIK10.40744321
112DAPK30.40197722
113CDK40.40015906
114IKBKE0.39933536
115OXSR10.39562734
116RPS6KB10.39406459
117HIPK20.38835356
118MTOR0.37128659
119PDK20.37100109
120LATS10.35012550
121PRKAA20.34205268
122MAP3K100.33994726
123CSNK1D0.33575303
124MARK20.32688444
125MET0.31713592
126MAP2K40.31208357
127CDK20.30272077
128EIF2AK20.29767011
129RPS6KA10.29216985
130MAP3K80.29019305
131DYRK20.28054799
132AKT20.27626908
133AURKB0.27150393
134MAPK40.26840575
135PRKCD0.26826200
136PAK10.26758337
137FER0.26660254
138PDGFRB0.26287926
139BRD40.26287694
140BUB10.26066652
141GRK10.22864519
142INSR0.22740215
143ATM0.22614361
144CSNK1G10.22338352
145MAPKAPK50.22019443
146LCK0.21361217
147CAMK2G0.21079113
148MAPK10.20955152
149PRPF4B0.20756711
150CSNK2A20.20403526
151NEK10.20022685
152PAK40.19891310
153MAP2K10.19666461
154PRKCH0.17042698
155TRIM280.16907875
156CDK50.13598595
157CDK10.12843345
158PRKCQ0.11153303
159ROCK10.10738229
160STK380.09656788

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006048.53869546
2Systemic lupus erythematosus_Homo sapiens_hsa053225.36414658
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001305.18804570
4Fatty acid biosynthesis_Homo sapiens_hsa000614.83110338
5Mismatch repair_Homo sapiens_hsa034304.47542440
6DNA replication_Homo sapiens_hsa030303.10417831
7Base excision repair_Homo sapiens_hsa034102.92532484
8One carbon pool by folate_Homo sapiens_hsa006702.45705926
9Alcoholism_Homo sapiens_hsa050342.26130023
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18206336
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09553875
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.03954370
13Nitrogen metabolism_Homo sapiens_hsa009102.01149883
14Nucleotide excision repair_Homo sapiens_hsa034201.97768238
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.95759884
16Fanconi anemia pathway_Homo sapiens_hsa034601.87453556
17p53 signaling pathway_Homo sapiens_hsa041151.79164755
18Folate biosynthesis_Homo sapiens_hsa007901.76174490
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64204678
20Arginine biosynthesis_Homo sapiens_hsa002201.63629031
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.60905810
22Taste transduction_Homo sapiens_hsa047421.58390118
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.57803426
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56426208
25Viral carcinogenesis_Homo sapiens_hsa052031.55200072
26Homologous recombination_Homo sapiens_hsa034401.48613469
27Vitamin digestion and absorption_Homo sapiens_hsa049771.46841688
28Arginine and proline metabolism_Homo sapiens_hsa003301.40939071
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37827269
30RNA transport_Homo sapiens_hsa030131.37028497
31Bladder cancer_Homo sapiens_hsa052191.36546724
32Biosynthesis of amino acids_Homo sapiens_hsa012301.35242144
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.31952220
34Other glycan degradation_Homo sapiens_hsa005111.27058225
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26032679
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24939570
37mTOR signaling pathway_Homo sapiens_hsa041501.21348918
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19793281
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18677705
40Sulfur relay system_Homo sapiens_hsa041221.16811468
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14968344
42Notch signaling pathway_Homo sapiens_hsa043301.14213688
43Staphylococcus aureus infection_Homo sapiens_hsa051501.13354571
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12225942
45Hippo signaling pathway_Homo sapiens_hsa043901.10990308
46Fatty acid metabolism_Homo sapiens_hsa012121.08032432
47Nicotine addiction_Homo sapiens_hsa050331.06023097
48mRNA surveillance pathway_Homo sapiens_hsa030151.05289908
49Lysine degradation_Homo sapiens_hsa003101.04866535
50Selenocompound metabolism_Homo sapiens_hsa004501.04667637
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03417365
52Adherens junction_Homo sapiens_hsa045201.02812844
53Spliceosome_Homo sapiens_hsa030401.00441405
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98902920
55Steroid biosynthesis_Homo sapiens_hsa001000.98134390
56Complement and coagulation cascades_Homo sapiens_hsa046100.97150579
57Fructose and mannose metabolism_Homo sapiens_hsa000510.95389045
58Lysosome_Homo sapiens_hsa041420.92477113
59Ovarian steroidogenesis_Homo sapiens_hsa049130.90694787
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87879373
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86771619
62MicroRNAs in cancer_Homo sapiens_hsa052060.85638986
63Linoleic acid metabolism_Homo sapiens_hsa005910.84810707
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81901035
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78408909
66Hedgehog signaling pathway_Homo sapiens_hsa043400.78077456
67Cell cycle_Homo sapiens_hsa041100.77354477
68Circadian rhythm_Homo sapiens_hsa047100.76320859
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75528648
70Inositol phosphate metabolism_Homo sapiens_hsa005620.74915527
71Calcium signaling pathway_Homo sapiens_hsa040200.74887792
72TGF-beta signaling pathway_Homo sapiens_hsa043500.71383219
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70604149
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68538837
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67395162
76Melanogenesis_Homo sapiens_hsa049160.67302287
77Vitamin B6 metabolism_Homo sapiens_hsa007500.65600252
78Pyruvate metabolism_Homo sapiens_hsa006200.65230118
79Basal cell carcinoma_Homo sapiens_hsa052170.64117025
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63972544
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63804043
82ABC transporters_Homo sapiens_hsa020100.63516958
83RNA polymerase_Homo sapiens_hsa030200.63167412
84Phenylalanine metabolism_Homo sapiens_hsa003600.58595532
85Galactose metabolism_Homo sapiens_hsa000520.57760582
86Fat digestion and absorption_Homo sapiens_hsa049750.57335141
87Phototransduction_Homo sapiens_hsa047440.56843220
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.54689410
89Small cell lung cancer_Homo sapiens_hsa052220.53949224
90Prion diseases_Homo sapiens_hsa050200.53529946
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51138580
92Ribosome_Homo sapiens_hsa030100.49813966
93Cocaine addiction_Homo sapiens_hsa050300.49593753
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.46838073
95Ether lipid metabolism_Homo sapiens_hsa005650.45890152
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44882444
97Starch and sucrose metabolism_Homo sapiens_hsa005000.43112544
98Endocytosis_Homo sapiens_hsa041440.39951661
99Dorso-ventral axis formation_Homo sapiens_hsa043200.39661404
100Histidine metabolism_Homo sapiens_hsa003400.39095344
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38963362
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.37177347
103Tight junction_Homo sapiens_hsa045300.37174081
104Phagosome_Homo sapiens_hsa041450.36494969
105Chemical carcinogenesis_Homo sapiens_hsa052040.35079601
106VEGF signaling pathway_Homo sapiens_hsa043700.34997455
107Wnt signaling pathway_Homo sapiens_hsa043100.34746220
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34704604
109Fatty acid degradation_Homo sapiens_hsa000710.34208996
110Apoptosis_Homo sapiens_hsa042100.33589743
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.32124593
112Legionellosis_Homo sapiens_hsa051340.31982973
113Basal transcription factors_Homo sapiens_hsa030220.30407496
114Colorectal cancer_Homo sapiens_hsa052100.30328819
115Gap junction_Homo sapiens_hsa045400.30184178
116Mineral absorption_Homo sapiens_hsa049780.29284869
117Metabolic pathways_Homo sapiens_hsa011000.28912348
118Primary immunodeficiency_Homo sapiens_hsa053400.28684177
119Glycerolipid metabolism_Homo sapiens_hsa005610.24640359
120Glutathione metabolism_Homo sapiens_hsa004800.23605318
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23523442
122Peroxisome_Homo sapiens_hsa041460.23316698
123Insulin signaling pathway_Homo sapiens_hsa049100.22715477
124Insulin resistance_Homo sapiens_hsa049310.21717398
125Tryptophan metabolism_Homo sapiens_hsa003800.21163946
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19668272
127PPAR signaling pathway_Homo sapiens_hsa033200.19504302
128Shigellosis_Homo sapiens_hsa051310.19213451
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18300853
130Oocyte meiosis_Homo sapiens_hsa041140.18239996
131Arachidonic acid metabolism_Homo sapiens_hsa005900.18049742
132Herpes simplex infection_Homo sapiens_hsa051680.18027612
133MAPK signaling pathway_Homo sapiens_hsa040100.17514822
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.16737799
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16706088
136Pyrimidine metabolism_Homo sapiens_hsa002400.16660392
137Hepatitis B_Homo sapiens_hsa051610.16605757
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16020309
139Glucagon signaling pathway_Homo sapiens_hsa049220.15090494
140Tyrosine metabolism_Homo sapiens_hsa003500.14872231
141Proteoglycans in cancer_Homo sapiens_hsa052050.14765617
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.14567715
143Sphingolipid metabolism_Homo sapiens_hsa006000.13538379
144Prostate cancer_Homo sapiens_hsa052150.13537149
145Focal adhesion_Homo sapiens_hsa045100.13193766
146NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13157755
147Measles_Homo sapiens_hsa051620.12857120
148ErbB signaling pathway_Homo sapiens_hsa040120.12462143
149Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.12315165
150Retinol metabolism_Homo sapiens_hsa008300.11750462
151Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11722216
152Hepatitis C_Homo sapiens_hsa051600.08195642
153Adipocytokine signaling pathway_Homo sapiens_hsa049200.07566719
154Glutamatergic synapse_Homo sapiens_hsa047240.06821957
155cAMP signaling pathway_Homo sapiens_hsa040240.05516159
156Bile secretion_Homo sapiens_hsa049760.05240179
157Amphetamine addiction_Homo sapiens_hsa050310.05211873
158Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.04424563

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