RNF24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.01982124
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.01982124
3modulation by symbiont of host immune response (GO:0052553)6.01982124
4positive regulation by symbiont of host defense response (GO:0052509)6.01982124
5modulation by symbiont of host defense response (GO:0052031)6.01982124
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.01982124
7positive regulation of gamma-delta T cell activation (GO:0046645)5.06754301
8cellular extravasation (GO:0045123)5.04912777
9response to peptidoglycan (GO:0032494)4.98271757
10neutrophil activation involved in immune response (GO:0002283)4.96492963
11neutrophil mediated immunity (GO:0002446)4.81300030
12negative regulation of cell killing (GO:0031342)4.75463217
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.75463217
14microglial cell activation (GO:0001774)4.72880849
15detection of molecule of bacterial origin (GO:0032490)4.72795118
16leukocyte migration involved in inflammatory response (GO:0002523)4.58553935
17macrophage activation involved in immune response (GO:0002281)4.55575400
18response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.45941326
19response to host immune response (GO:0052572)4.45941326
20neutrophil activation (GO:0042119)4.40942350
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.40178964
22positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.35064604
23negative regulation of interleukin-12 production (GO:0032695)4.02835245
24detection of other organism (GO:0098543)4.02365644
25myeloid leukocyte mediated immunity (GO:0002444)4.01735680
26regulation of B cell receptor signaling pathway (GO:0050855)3.97762272
27response to host (GO:0075136)3.94020712
28response to host defenses (GO:0052200)3.94020712
29response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.94020712
30positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.93813055
31detection of external biotic stimulus (GO:0098581)3.92966198
32granulocyte activation (GO:0036230)3.92229678
33regulation of interferon-beta biosynthetic process (GO:0045357)3.90371431
34regulation of mast cell activation (GO:0033003)3.81377441
35pyrimidine nucleobase catabolic process (GO:0006208)3.80591701
36positive regulation of mast cell activation (GO:0033005)3.80096608
37negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.78288063
38response to interleukin-15 (GO:0070672)3.76817232
39macrophage activation (GO:0042116)3.74885733
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.74200833
41axonal fasciculation (GO:0007413)3.68720304
42regulation of mast cell degranulation (GO:0043304)3.67101858
43negative regulation of erythrocyte differentiation (GO:0045647)3.64814433
44leukocyte aggregation (GO:0070486)3.63892396
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.63236579
46regulation of short-term neuronal synaptic plasticity (GO:0048172)3.62046024
47myeloid cell activation involved in immune response (GO:0002275)3.60361891
48detection of bacterium (GO:0016045)3.60060292
49locomotory exploration behavior (GO:0035641)3.59912366
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.59173476
51antigen processing and presentation of endogenous antigen (GO:0019883)3.55797352
52layer formation in cerebral cortex (GO:0021819)3.54751698
53respiratory burst (GO:0045730)3.53726719
54leukocyte degranulation (GO:0043299)3.51335841
55regulation of mast cell activation involved in immune response (GO:0033006)3.46793549
56negative regulation of hormone metabolic process (GO:0032351)3.46777012
57negative regulation of hormone biosynthetic process (GO:0032353)3.46777012
58glutamate secretion (GO:0014047)3.46263071
59synaptic vesicle maturation (GO:0016188)3.42562453
60cellular response to interleukin-15 (GO:0071350)3.42279452
61detection of biotic stimulus (GO:0009595)3.39384602
62vocalization behavior (GO:0071625)3.37340189
63positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.37328876
64negative regulation of T-helper cell differentiation (GO:0045623)3.34611771
65negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.34611771
66regulation of gamma-delta T cell activation (GO:0046643)3.34291995
67dendritic spine morphogenesis (GO:0060997)3.33153202
68dendrite morphogenesis (GO:0048813)3.30295942
69establishment of nucleus localization (GO:0040023)3.29455898
70positive regulation of B cell differentiation (GO:0045579)3.24203957
71negative regulation of T cell mediated immunity (GO:0002710)3.21752190
72central nervous system projection neuron axonogenesis (GO:0021952)3.21650463
73regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.20594231
74cell migration in hindbrain (GO:0021535)3.20580087
75positive regulation of granulocyte differentiation (GO:0030854)3.18757518
76synaptic vesicle docking involved in exocytosis (GO:0016081)3.17475611
77regulation of myeloid leukocyte mediated immunity (GO:0002886)3.16486443
78activated T cell proliferation (GO:0050798)3.15085840
79nucleobase catabolic process (GO:0046113)3.12175287
80neuron cell-cell adhesion (GO:0007158)3.10491167
81positive regulation of mast cell degranulation (GO:0043306)3.09065867
82positive regulation of mast cell activation involved in immune response (GO:0033008)3.09065867
83regulation of MHC class II biosynthetic process (GO:0045346)3.07708422
84synaptic vesicle exocytosis (GO:0016079)3.07066652
85regulation of interleukin-6 biosynthetic process (GO:0045408)3.06292658
86positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.06057697
87immunoglobulin mediated immune response (GO:0016064)3.03654096
88regulation of meiosis I (GO:0060631)3.03429897
89positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.02667795
90auditory behavior (GO:0031223)3.02342886
91negative regulation of leukocyte mediated immunity (GO:0002704)3.02046229
92response to muramyl dipeptide (GO:0032495)3.01590899
93negative regulation of phagocytosis (GO:0050765)3.00230090
94neuron recognition (GO:0008038)2.99081159
95antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98248335
96positive regulation of toll-like receptor signaling pathway (GO:0034123)2.95963626
97negative regulation of interleukin-6 production (GO:0032715)2.95273254
98regulation of B cell differentiation (GO:0045577)2.93564753
99regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.93493700
100negative regulation of catenin import into nucleus (GO:0035414)2.92917634
101positive regulation of meiosis (GO:0045836)2.91839984
102response to auditory stimulus (GO:0010996)2.91471895
103defense response to protozoan (GO:0042832)2.89773085
104regulation of erythrocyte differentiation (GO:0045646)2.87785111
105righting reflex (GO:0060013)2.86216361
106regulation of gamma-delta T cell differentiation (GO:0045586)2.85742074
107germinal center formation (GO:0002467)2.85362094
108regulation of leukocyte degranulation (GO:0043300)2.84858797
109ionotropic glutamate receptor signaling pathway (GO:0035235)2.81824287
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.81278691
111regulation of platelet aggregation (GO:0090330)2.80161730
112positive regulation of interferon-alpha production (GO:0032727)2.80086813
113cerebellar Purkinje cell differentiation (GO:0021702)2.78165766
114sequestering of extracellular ligand from receptor (GO:0035581)2.77559650
115negative regulation of interleukin-8 production (GO:0032717)2.74329746
116regulation of meiosis (GO:0040020)2.73468505
117regulation of regulated secretory pathway (GO:1903305)2.73412867
118glutamate receptor signaling pathway (GO:0007215)2.73101874
119interferon-gamma production (GO:0032609)2.72963551
120regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.72870957
121regulation of synaptic vesicle transport (GO:1902803)2.72644819
122sodium ion export (GO:0071436)2.70043175
123oxygen transport (GO:0015671)2.69952452
124lens morphogenesis in camera-type eye (GO:0002089)2.69491090
125regulation of synaptic vesicle exocytosis (GO:2000300)2.69267459
126positive regulation of meiotic cell cycle (GO:0051446)2.69261939
127dendritic cell migration (GO:0036336)2.68820474
128chondrocyte proliferation (GO:0035988)2.68263660
129B cell receptor signaling pathway (GO:0050853)2.67088333
130response to protozoan (GO:0001562)2.66904726
131exploration behavior (GO:0035640)2.66772074
132regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.64467615
133regulation of interferon-alpha production (GO:0032647)2.64231399
134regulation of T-helper 2 cell differentiation (GO:0045628)2.63897755
135regulation of memory T cell differentiation (GO:0043380)2.63822093
136negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.63668245
137regulation of neuronal synaptic plasticity (GO:0048168)2.63520922
138regulation of glutamate receptor signaling pathway (GO:1900449)2.63272797
139neurotransmitter-gated ion channel clustering (GO:0072578)2.63097850
140superoxide anion generation (GO:0042554)2.62779034
141purinergic nucleotide receptor signaling pathway (GO:0035590)2.62594077
142mast cell activation (GO:0045576)2.62190939
143neutrophil chemotaxis (GO:0030593)2.61769589
144positive regulation of interferon-beta production (GO:0032728)2.61663366
145myeloid leukocyte activation (GO:0002274)2.61187620
146proline transport (GO:0015824)2.60317659
147protein localization to synapse (GO:0035418)2.59279843
148cerebral cortex radially oriented cell migration (GO:0021799)2.56163876
149regulation of long-term neuronal synaptic plasticity (GO:0048169)2.55039812
150negative regulation of dendrite development (GO:2000171)2.53728201
151response to pheromone (GO:0019236)2.52772838
152synaptic transmission, glutamatergic (GO:0035249)2.50645429
153central nervous system neuron axonogenesis (GO:0021955)2.50395953
154ovulation cycle (GO:0042698)2.47431238
155G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46262188
156eye photoreceptor cell differentiation (GO:0001754)2.45523699
157photoreceptor cell differentiation (GO:0046530)2.45523699
158innervation (GO:0060384)2.44139197
159L-amino acid import (GO:0043092)2.44110249
160cellular potassium ion homeostasis (GO:0030007)2.43968888
161fibroblast migration (GO:0010761)2.43213328
162dendritic spine organization (GO:0097061)2.42414432
163piRNA metabolic process (GO:0034587)2.41403354
164female gonad development (GO:0008585)2.38198122
165regulation of female gonad development (GO:2000194)2.38185603
166negative regulation of sodium ion transport (GO:0010766)2.35195715
167nucleus localization (GO:0051647)2.33320021
168regulation of meiotic cell cycle (GO:0051445)2.32569852
169neurotransmitter secretion (GO:0007269)2.31485773
170cell communication by electrical coupling (GO:0010644)2.30514918
171metanephric tubule development (GO:0072170)2.25600891
172metanephric nephron tubule development (GO:0072234)2.25600891
173synaptic vesicle endocytosis (GO:0048488)2.22239176
174cerebellar granule cell differentiation (GO:0021707)2.21476106
175stress fiber assembly (GO:0043149)2.18836520
176negative regulation of oligodendrocyte differentiation (GO:0048715)2.18102344
177neuron projection morphogenesis (GO:0048812)2.17822964
178vitamin transmembrane transport (GO:0035461)2.17679788
179regulation of synaptic transmission, glutamatergic (GO:0051966)2.17162976
180regulation of cAMP-dependent protein kinase activity (GO:2000479)2.17133740
181neuron-neuron synaptic transmission (GO:0007270)2.17110848
182regulation of synapse structural plasticity (GO:0051823)2.17044993
183regulation of dendritic spine morphogenesis (GO:0061001)2.14665532
184cellular sodium ion homeostasis (GO:0006883)2.13801563
185dermatan sulfate metabolic process (GO:0030205)2.13748720
186mesenchymal-epithelial cell signaling (GO:0060638)2.13630789
187glial cell proliferation (GO:0014009)2.13477631
188smooth muscle tissue development (GO:0048745)2.12860307
189dermatan sulfate biosynthetic process (GO:0030208)2.10848379
190mechanosensory behavior (GO:0007638)2.10692984
191behavioral defense response (GO:0002209)2.10393189
192behavioral fear response (GO:0001662)2.10393189
193response to histamine (GO:0034776)2.09023805
194renal tubule development (GO:0061326)2.08402389
195prepulse inhibition (GO:0060134)2.08257562
196regulation of Rac GTPase activity (GO:0032314)2.07693306
197cartilage morphogenesis (GO:0060536)2.07670242
198positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.07310803
199inner ear receptor cell development (GO:0060119)2.06947085
200olfactory bulb development (GO:0021772)2.06738631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.28875199
2EZH2_22144423_ChIP-Seq_EOC_Human4.24412411
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.70373831
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.60986552
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.51534082
6SCL_19346495_ChIP-Seq_HPC-7_Human3.45703956
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.37777349
8GBX2_23144817_ChIP-Seq_PC3_Human3.00261178
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.87397971
10VDR_21846776_ChIP-Seq_THP-1_Human2.84388484
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.79972626
12VDR_24763502_ChIP-Seq_THP-1_Human2.72667964
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63415120
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.58428394
15SPI1_23127762_ChIP-Seq_K562_Human2.42259608
16RUNX_20019798_ChIP-Seq_JUKART_Human2.38508137
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.29211320
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26201922
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26201922
20MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.23230333
21SPI1_23547873_ChIP-Seq_NB4_Human2.20485650
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17455346
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12891985
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12450652
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.09099746
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02976153
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02246352
28* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02239026
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.98615065
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98118919
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98023616
32AR_21572438_ChIP-Seq_LNCaP_Human1.96542642
33UTX_26944678_Chip-Seq_JUKART_Human1.95460503
34MAF_26560356_Chip-Seq_TH1_Human1.90568006
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.90379247
36* VDR_24787735_ChIP-Seq_THP-1_Human1.89790054
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.89264376
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.87923848
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.86868283
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86618387
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85517073
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.85092855
43DROSHA_22980978_ChIP-Seq_HELA_Human1.85039113
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84763739
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84652243
46* RUNX1_22412390_ChIP-Seq_EML_Mouse1.84497114
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84062704
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.83873481
49MYB_26560356_Chip-Seq_TH2_Human1.81404041
50* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.81083396
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79901726
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78775067
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78715281
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76514674
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75315909
56* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.74679260
57CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.74653300
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.74073529
59* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73974290
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73539572
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.72588522
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70786457
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68722305
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.68637411
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64207270
66GATA1_19941826_ChIP-Seq_K562_Human1.64197216
67GATA3_27048872_Chip-Seq_THYMUS_Human1.63219659
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.60363110
69IGF1R_20145208_ChIP-Seq_DFB_Human1.58191500
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58159427
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57673695
72SMAD4_21799915_ChIP-Seq_A2780_Human1.54770078
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53786325
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51588251
75P300_19829295_ChIP-Seq_ESCs_Human1.47112502
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46996837
77MYB_26560356_Chip-Seq_TH1_Human1.46902422
78FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46396000
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45047908
80MAF_26560356_Chip-Seq_TH2_Human1.44709321
81BCL6_27268052_Chip-Seq_Bcells_Human1.44319634
82REST_21632747_ChIP-Seq_MESCs_Mouse1.43896324
83KDM2B_26808549_Chip-Seq_DND41_Human1.43848735
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43050693
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42100587
86TRIM28_21343339_ChIP-Seq_HEK293_Human1.41584049
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40755096
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40487500
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39448061
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36468933
91TCF7_22412390_ChIP-Seq_EML_Mouse1.34754720
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34538194
93GATA2_19941826_ChIP-Seq_K562_Human1.32257334
94AR_25329375_ChIP-Seq_VCAP_Human1.32193406
95* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32156728
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29605134
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28297059
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27567788
99GATA3_26560356_Chip-Seq_TH2_Human1.27152593
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.27046563
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.26446216
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26001778
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25824404
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25494941
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24793335
106* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24650137
107RNF2_27304074_Chip-Seq_NSC_Mouse1.23071901
108STAT3_23295773_ChIP-Seq_U87_Human1.22489968
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20917601
110* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20842604
111RXR_22108803_ChIP-Seq_LS180_Human1.19825782
112MYC_22102868_ChIP-Seq_BL_Human1.19704953
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19217216
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19217216
115* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17382108
116TCF4_18268006_ChIP-ChIP_LS174T_Human1.16263991
117ZNF274_21170338_ChIP-Seq_K562_Hela1.15797269
118* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15612652
119* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15552405
120KDM2B_26808549_Chip-Seq_JURKAT_Human1.14886002
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14875361
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14738577
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13763849
124FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13313227
125CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12822894
126SMAD4_21741376_ChIP-Seq_HESCs_Human1.12523063
127RARB_27405468_Chip-Seq_BRAIN_Mouse1.12442621
128CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12334272
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12268968
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11976343
131IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11964493
132IRF1_19129219_ChIP-ChIP_H3396_Human1.11432668
133NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11312461
134ARNT_22903824_ChIP-Seq_MCF-7_Human1.10813497
135TAF15_26573619_Chip-Seq_HEK293_Human1.10414270
136AR_19668381_ChIP-Seq_PC3_Human1.10336876
137RING1B_27294783_Chip-Seq_ESCs_Mouse1.10333893
138GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09931440
139STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09564288
140VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08687050
141RING1B_27294783_Chip-Seq_NPCs_Mouse1.08203375
142CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06789811
143MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06740472
144* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06672299
145* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06450262
146SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06408868
147EP300_21415370_ChIP-Seq_HL-1_Mouse1.06201490
148GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05898772
149YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05707859
150TP53_18474530_ChIP-ChIP_U2OS_Human1.05599933
151SMRT_27268052_Chip-Seq_Bcells_Human1.05216767
152SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04618880
153BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03616979
154UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03541288
155RUNX2_22187159_ChIP-Seq_PCA_Human1.03202766
156REST_18959480_ChIP-ChIP_MESCs_Mouse1.02975568
157* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02847922
158* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02326236
159* NCOR1_26117541_ChIP-Seq_K562_Human1.01843524
160BCAT_22108803_ChIP-Seq_LS180_Human1.01736070
161SMAD3_21741376_ChIP-Seq_HESCs_Human1.01328198
162PRDM14_20953172_ChIP-Seq_ESCs_Human1.01321826
163* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01276562
164GATA2_21666600_ChIP-Seq_HMVEC_Human1.01179568
165SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00534787
166CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00344352
167EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99978377
168ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99946792
169TP53_16413492_ChIP-PET_HCT116_Human0.99608683
170BCOR_27268052_Chip-Seq_Bcells_Human0.99006594
171TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98793667
172SMAD4_21741376_ChIP-Seq_EPCs_Human0.98734338
173TP63_19390658_ChIP-ChIP_HaCaT_Human0.98053174
174SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97948648
175GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96393160
176KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95729506
177CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93635711
178PU_27001747_Chip-Seq_BMDM_Mouse0.92892974
179RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92771105
180STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89963974
181OCT4_19829295_ChIP-Seq_ESCs_Human0.89885116
182* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88830698
183* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88221510
184* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87991164
185P68_20966046_ChIP-Seq_HELA_Human0.87599254
186CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87118795
187RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85432923
188RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85034928
189E2F1_20622854_ChIP-Seq_HELA_Human0.84851968
190CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83074333
191SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82799803
192CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82790224
193P300_27268052_Chip-Seq_Bcells_Human0.82152015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.62432244
2MP0004859_abnormal_synaptic_plasticity5.31030822
3MP0003436_decreased_susceptibility_to3.72046758
4MP0003303_peritoneal_inflammation3.41806461
5MP0000569_abnormal_digit_pigmentation3.28118400
6MP0001835_abnormal_antigen_presentation2.96919612
7MP0002419_abnormal_innate_immunity2.87049070
8MP0005464_abnormal_platelet_physiology2.65269221
9MP0004270_analgesia2.63550077
10MP0003635_abnormal_synaptic_transmissio2.57337527
11MP0003880_abnormal_central_pattern2.50363797
12MP0005025_abnormal_response_to2.50025116
13MP0000778_abnormal_nervous_system2.49231484
14MP0002102_abnormal_ear_morphology2.46694470
15MP0001800_abnormal_humoral_immune2.40316720
16MP0005503_abnormal_tendon_morphology2.30986476
17MP0002734_abnormal_mechanical_nocicepti2.29709917
18MP0005000_abnormal_immune_tolerance2.28773748
19MP0009785_altered_susceptibility_to2.24014597
20MP0002723_abnormal_immune_serum2.23462303
21MP0009764_decreased_sensitivity_to2.19944548
22MP0002132_abnormal_respiratory_system2.19217537
23MP0002420_abnormal_adaptive_immunity2.16682196
24MP0002063_abnormal_learning/memory/cond2.14320954
25MP0001819_abnormal_immune_cell2.14304922
26MP0002249_abnormal_larynx_morphology2.13896954
27MP0001958_emphysema2.11303681
28MP0005671_abnormal_response_to2.08795681
29MP0005397_hematopoietic_system_phenotyp2.05768650
30MP0001545_abnormal_hematopoietic_system2.05768650
31MP0002452_abnormal_antigen_presenting2.05397433
32MP0009278_abnormal_bone_marrow2.04152347
33MP0002653_abnormal_ependyma_morphology1.99336497
34MP0003183_abnormal_peptide_metabolism1.97522011
35MP0001486_abnormal_startle_reflex1.97010719
36MP0001790_abnormal_immune_system1.96953625
37MP0005387_immune_system_phenotype1.96953625
38MP0004130_abnormal_muscle_cell1.96219120
39MP0002148_abnormal_hypersensitivity_rea1.91656748
40MP0001986_abnormal_taste_sensitivity1.90271507
41MP0006276_abnormal_autonomic_nervous1.87392726
42MP0003828_pulmonary_edema1.85085551
43MP0001533_abnormal_skeleton_physiology1.82420277
44MP0000685_abnormal_immune_system1.78974402
45MP0006082_CNS_inflammation1.75767059
46MP0004858_abnormal_nervous_system1.75249250
47MP0006292_abnormal_olfactory_placode1.74904240
48MP0002398_abnormal_bone_marrow1.73947919
49MP0005423_abnormal_somatic_nervous1.71868953
50MP0002733_abnormal_thermal_nociception1.68572336
51MP0002277_abnormal_respiratory_mucosa1.66115576
52MP0000716_abnormal_immune_system1.64749193
53MP0009250_abnormal_appendicular_skeleto1.64112937
54MP0008961_abnormal_basal_metabolism1.63394247
55MP0002572_abnormal_emotion/affect_behav1.61917765
56MP0010368_abnormal_lymphatic_system1.60475079
57MP0002405_respiratory_system_inflammati1.59318219
58MP0005174_abnormal_tail_pigmentation1.59313301
59MP0003172_abnormal_lysosome_physiology1.53687411
60MP0005646_abnormal_pituitary_gland1.53201653
61MP0009745_abnormal_behavioral_response1.53075090
62MP0004885_abnormal_endolymph1.52967772
63MP0003656_abnormal_erythrocyte_physiolo1.51884636
64MP0005083_abnormal_biliary_tract1.49830776
65MP0001501_abnormal_sleep_pattern1.49729549
66MP0000015_abnormal_ear_pigmentation1.49618711
67MP0000049_abnormal_middle_ear1.48473553
68MP0000465_gastrointestinal_hemorrhage1.44949212
69MP0001299_abnormal_eye_distance/1.44922887
70MP0001177_atelectasis1.43622561
71MP0000689_abnormal_spleen_morphology1.42731182
72MP0006054_spinal_hemorrhage1.39453756
73MP0003938_abnormal_ear_development1.39115547
74MP0008260_abnormal_autophagy1.38165365
75MP0002064_seizures1.38143967
76MP0002722_abnormal_immune_system1.37391499
77MP0005508_abnormal_skeleton_morphology1.36161352
78MP0000534_abnormal_ureter_morphology1.35968732
79MP0001845_abnormal_inflammatory_respons1.34222444
80MP0001968_abnormal_touch/_nociception1.33607611
81MP0010030_abnormal_orbit_morphology1.32188547
82MP0001346_abnormal_lacrimal_gland1.31463319
83MP0002429_abnormal_blood_cell1.30972524
84MP0003755_abnormal_palate_morphology1.30525917
85MP0005187_abnormal_penis_morphology1.28808613
86MP0001502_abnormal_circadian_rhythm1.28208755
87MP0005248_abnormal_Harderian_gland1.26793698
88MP0005257_abnormal_intraocular_pressure1.25831386
89MP0001970_abnormal_pain_threshold1.25558517
90MP0002184_abnormal_innervation1.24512851
91MP0009780_abnormal_chondrocyte_physiolo1.24218465
92MP0001348_abnormal_lacrimal_gland1.22833179
93MP0003191_abnormal_cellular_cholesterol1.20467868
94MP0003942_abnormal_urinary_system1.20051848
95MP0002116_abnormal_craniofacial_bone1.19883759
96MP0005623_abnormal_meninges_morphology1.19431506
97MP0002138_abnormal_hepatobiliary_system1.18738615
98MP0003300_gastrointestinal_ulcer1.18347003
99MP0003787_abnormal_imprinting1.17957798
100MP0005499_abnormal_olfactory_system1.17827529
101MP0005394_taste/olfaction_phenotype1.17827529
102MP0002396_abnormal_hematopoietic_system1.17386528
103MP0003123_paternal_imprinting1.15077277
104MP0009046_muscle_twitch1.14987814
105MP0005164_abnormal_response_to1.14382903
106MP0003937_abnormal_limbs/digits/tail_de1.14032270
107MP0003646_muscle_fatigue1.13649330
108MP0008789_abnormal_olfactory_epithelium1.13478737
109MP0004381_abnormal_hair_follicle1.13249686
110MP0009765_abnormal_xenobiotic_induced1.13163362
111MP0000703_abnormal_thymus_morphology1.11874457
112MP0002557_abnormal_social/conspecific_i1.11437321
113MP0008469_abnormal_protein_level1.10345688
114MP0010155_abnormal_intestine_physiology1.08799444
115MP0001440_abnormal_grooming_behavior1.07085334
116MP0003121_genomic_imprinting1.07004709
117MP0002177_abnormal_outer_ear1.06953661
118MP0008004_abnormal_stomach_pH1.06905439
119MP0004811_abnormal_neuron_physiology1.06712994
120MP0002928_abnormal_bile_duct1.05666530
121MP0002152_abnormal_brain_morphology1.03372668
122MP0003866_abnormal_defecation1.02208070
123MP0004272_abnormal_basement_membrane1.01037547
124MP0000767_abnormal_smooth_muscle1.00484654
125MP0003861_abnormal_nervous_system0.97926817
126MP0005310_abnormal_salivary_gland0.97347525
127MP0003935_abnormal_craniofacial_develop0.96418248
128MP0000343_altered_response_to0.95821666
129MP0000631_abnormal_neuroendocrine_gland0.95582139
130MP0001853_heart_inflammation0.95527938
131MP0003385_abnormal_body_wall0.94882521
132MP0003329_amyloid_beta_deposits0.94420727
133MP0002736_abnormal_nociception_after0.94396610
134MP0003115_abnormal_respiratory_system0.94224485
135MP0002067_abnormal_sensory_capabilities0.93931038
136MP0002882_abnormal_neuron_morphology0.93892197
137MP0002272_abnormal_nervous_system0.92663261
138MP0005451_abnormal_body_composition0.92660248
139MP0005390_skeleton_phenotype0.92396314
140MP0002089_abnormal_postnatal_growth/wei0.92273574
141MP0002932_abnormal_joint_morphology0.88891438
142MP0004142_abnormal_muscle_tone0.88815427
143MP0000566_synostosis0.88399571
144MP0004947_skin_inflammation0.87642309
145MP0000163_abnormal_cartilage_morphology0.86739583
146MP0001905_abnormal_dopamine_level0.86705152
147MP0004883_abnormal_blood_vessel0.86657216
148MP0000955_abnormal_spinal_cord0.86101366
149MP0002233_abnormal_nose_morphology0.85939610
150MP0005377_hearing/vestibular/ear_phenot0.85552136
151MP0003878_abnormal_ear_physiology0.85552136
152MP0002876_abnormal_thyroid_physiology0.84678047
153MP0005084_abnormal_gallbladder_morpholo0.83360124
154MP0001849_ear_inflammation0.83015373
155MP0003279_aneurysm0.82530808
156MP0001984_abnormal_olfaction0.81833353
157MP0001663_abnormal_digestive_system0.81168345
158MP0003763_abnormal_thymus_physiology0.80600549
159MP0003091_abnormal_cell_migration0.80099183
160MP0001119_abnormal_female_reproductive0.79018483
161MP0001879_abnormal_lymphatic_vessel0.78961705
162MP0005386_behavior/neurological_phenoty0.78948968
163MP0004924_abnormal_behavior0.78948968
164MP0003252_abnormal_bile_duct0.78721725
165MP0001851_eye_inflammation0.75028663
166MP0000858_altered_metastatic_potential0.70547530
167MP0001188_hyperpigmentation0.68940252
168MP0002735_abnormal_chemical_nociception0.68510900
169MP0003122_maternal_imprinting0.68420673
170MP0009763_increased_sensitivity_to0.67710806
171MP0004484_altered_response_of0.65833971
172MP0002998_abnormal_bone_remodeling0.65393908
173MP0000230_abnormal_systemic_arterial0.65306056
174MP0003045_fibrosis0.65096297
175MP0003075_altered_response_to0.65040117
176MP0004808_abnormal_hematopoietic_stem0.63092853
177MP0005409_darkened_coat_color0.62665684
178MP0005075_abnormal_melanosome_morpholog0.62326770
179MP0008877_abnormal_DNA_methylation0.60696649
180MP0008874_decreased_physiological_sensi0.58918800
181MP0002332_abnormal_exercise_endurance0.56641279
182MP0005535_abnormal_body_temperature0.56426951
183MP0002095_abnormal_skin_pigmentation0.55410935
184MP0003011_delayed_dark_adaptation0.54861477
185MP0003638_abnormal_response/metabolism_0.52549739

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)5.36575745
2Elevated erythrocyte sedimentation rate (HP:0003565)5.26942174
3Orchitis (HP:0100796)5.05782595
4Stomatitis (HP:0010280)4.92899746
5Retrobulbar optic neuritis (HP:0100654)4.85905737
6Optic neuritis (HP:0100653)4.85905737
7Recurrent abscess formation (HP:0002722)4.74190804
8Prolonged bleeding time (HP:0003010)4.59232322
9Recurrent bacterial skin infections (HP:0005406)4.56479051
10Eczematoid dermatitis (HP:0000976)4.48504289
11Abnormality of the heme biosynthetic pathway (HP:0010472)4.20316397
12Hypochromic microcytic anemia (HP:0004840)4.10025691
13Abnormality of macrophages (HP:0004311)3.97631997
14Recurrent fungal infections (HP:0002841)3.91672606
15Peritonitis (HP:0002586)3.83189611
16Gastrointestinal infarctions (HP:0005244)3.82505943
17Chronic obstructive pulmonary disease (HP:0006510)3.74048816
18Obstructive lung disease (HP:0006536)3.74048816
19Keratoconjunctivitis (HP:0001096)3.60845616
20Petechiae (HP:0000967)3.59747627
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.56218549
22Keratoconjunctivitis sicca (HP:0001097)3.55733473
23Chronic mucocutaneous candidiasis (HP:0002728)3.54718662
24Recurrent cutaneous fungal infections (HP:0011370)3.54718662
25Mediastinal lymphadenopathy (HP:0100721)3.45420057
26Recurrent gram-negative bacterial infections (HP:0005420)3.39151197
27Encephalitis (HP:0002383)3.38763501
28Elfin facies (HP:0004428)3.34158195
29Epistaxis (HP:0000421)3.31528742
30Focal motor seizures (HP:0011153)3.25849196
31Absent rod-and cone-mediated responses on ERG (HP:0007688)3.25134717
32Recurrent skin infections (HP:0001581)3.23146928
33Leukocytosis (HP:0001974)3.22677729
34Papillary thyroid carcinoma (HP:0002895)3.21614010
35Hypochromic anemia (HP:0001931)3.19621423
36Spontaneous hematomas (HP:0007420)3.15144596
37Gingival bleeding (HP:0000225)3.06828526
38Meningitis (HP:0001287)3.05804941
39Overriding aorta (HP:0002623)3.02346101
40Chest pain (HP:0100749)3.01904973
41Renovascular hypertension (HP:0100817)2.99389337
42Episodic fever (HP:0001954)2.97222396
43Shallow orbits (HP:0000586)2.93144674
44Pulmonary infiltrates (HP:0002113)2.88850102
45Aplasia involving bones of the upper limbs (HP:0009823)2.88347857
46Aplasia of the phalanges of the hand (HP:0009802)2.88347857
47Aplasia involving bones of the extremities (HP:0009825)2.88347857
48Vasculitis (HP:0002633)2.87609289
49Broad metatarsal (HP:0001783)2.86542735
50Hyperacusis (HP:0010780)2.85620849
51Microcytic anemia (HP:0001935)2.79772172
52Hemoptysis (HP:0002105)2.78418458
53Renal duplication (HP:0000075)2.73594605
54Urticaria (HP:0001025)2.67672355
55Bladder diverticulum (HP:0000015)2.65653980
56Arterial thrombosis (HP:0004420)2.62614199
57Granulocytopenia (HP:0001913)2.61813723
58Flat cornea (HP:0007720)2.60811598
59Focal seizures (HP:0007359)2.60330443
60Abnormality of the diencephalon (HP:0010662)2.51272524
61Pustule (HP:0200039)2.50363997
62Gingivitis (HP:0000230)2.49807667
63Increased IgE level (HP:0003212)2.49464640
64Polyphagia (HP:0002591)2.48309909
65Anorexia (HP:0002039)2.47971235
66Pulmonary artery stenosis (HP:0004415)2.46631040
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.41933606
68Short 4th metacarpal (HP:0010044)2.41933606
69Abnormal eating behavior (HP:0100738)2.41923533
70Abnormal rod and cone electroretinograms (HP:0008323)2.38947341
71Vascular tortuosity (HP:0004948)2.38433008
72Enlarged penis (HP:0000040)2.36643298
73Panhypogammaglobulinemia (HP:0003139)2.35871880
74Hypoplastic toenails (HP:0001800)2.35795405
75Adrenal hypoplasia (HP:0000835)2.33498160
76Insomnia (HP:0100785)2.33434423
77Excessive salivation (HP:0003781)2.32998166
78Drooling (HP:0002307)2.32998166
79Epileptic encephalopathy (HP:0200134)2.31721456
80Myokymia (HP:0002411)2.31547375
81Cortical dysplasia (HP:0002539)2.30891151
82Abnormal platelet volume (HP:0011876)2.29674351
83Bronchomalacia (HP:0002780)2.29523120
84Eosinophilia (HP:0001880)2.25595432
85Progressive cerebellar ataxia (HP:0002073)2.24623578
86Abnormality of the pleura (HP:0002103)2.24135988
87Pulmonary embolism (HP:0002204)2.23685947
88Shawl scrotum (HP:0000049)2.18661951
89Bowel diverticulosis (HP:0005222)2.17202912
90Action tremor (HP:0002345)2.14466816
91Abnormal hemoglobin (HP:0011902)2.14198283
92Papilledema (HP:0001085)2.13889384
93Genetic anticipation (HP:0003743)2.13478360
94Broad-based gait (HP:0002136)2.13121750
95Febrile seizures (HP:0002373)2.08521747
96Vertigo (HP:0002321)2.07210342
97Polycythemia (HP:0001901)2.06998657
98Midline defect of the nose (HP:0004122)2.06945111
99Purpura (HP:0000979)2.06630349
100Keratitis (HP:0000491)2.06272015
101Mutism (HP:0002300)2.06045528
102Decreased central vision (HP:0007663)2.05530354
103Visual hallucinations (HP:0002367)2.03553188
104Anterior segment dysgenesis (HP:0007700)2.03415546
105Absent frontal sinuses (HP:0002688)2.01838925
106Arterial tortuosity (HP:0005116)2.00471975
107Abnormality of the peritoneum (HP:0002585)1.99711254
108Congenital stationary night blindness (HP:0007642)1.99666487
109Spondylolisthesis (HP:0003302)1.99238361
110Deviation of the hallux (HP:0010051)1.98628026
111Turricephaly (HP:0000262)1.97148942
112Tubular atrophy (HP:0000092)1.95249904
113Neonatal short-limb short stature (HP:0008921)1.94263187
114Cellulitis (HP:0100658)1.93469632
115Coronal craniosynostosis (HP:0004440)1.92645769
116Trigonocephaly (HP:0000243)1.92075684
117Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91475418
118Abnormality of T cells (HP:0002843)1.90779725
119Abnormality of eosinophils (HP:0001879)1.90442996
120Stomach cancer (HP:0012126)1.90130825
121Abnormality of T cell number (HP:0011839)1.88468299
122Impaired platelet aggregation (HP:0003540)1.87679483
123Abnormal platelet function (HP:0011869)1.87679483
124Bruising susceptibility (HP:0000978)1.86711257
125Ankle clonus (HP:0011448)1.86185573
126Menorrhagia (HP:0000132)1.86076271
127Urinary bladder sphincter dysfunction (HP:0002839)1.83809809
128Premature rupture of membranes (HP:0001788)1.83531954
129T lymphocytopenia (HP:0005403)1.83070060
130Short nail (HP:0001799)1.82588307
131Protruding tongue (HP:0010808)1.81887833
132Capillary hemangiomas (HP:0005306)1.81652263
133Microglossia (HP:0000171)1.81621005
134Attenuation of retinal blood vessels (HP:0007843)1.80822219
135Abnormality of the pericardium (HP:0001697)1.80368320
136Increased IgM level (HP:0003496)1.79999569
137Heterotopia (HP:0002282)1.79644388
138Gangrene (HP:0100758)1.78731783
139Torticollis (HP:0000473)1.78486142
140Aqueductal stenosis (HP:0002410)1.78237671
141Increased nuchal translucency (HP:0010880)1.77949234
142Narrow palate (HP:0000189)1.77896171
143Abnormality of iron homeostasis (HP:0011031)1.77597729
144Hemiplegia (HP:0002301)1.77101570
145Diplopia (HP:0000651)1.76775164
146Abnormality of binocular vision (HP:0011514)1.76775164
147Pointed chin (HP:0000307)1.76120315
148Hallux valgus (HP:0001822)1.75920194
149Abnormality of the labia minora (HP:0012880)1.75758323
150Neurodegeneration (HP:0002180)1.75328474
151Thyroid carcinoma (HP:0002890)1.73404559
152Absent speech (HP:0001344)1.73252288
153Cheilitis (HP:0100825)1.73251995
154Abnormality of the middle phalanges of the toes (HP:0010183)1.72899590
155Sepsis (HP:0100806)1.72432447
156Genu recurvatum (HP:0002816)1.70893428
157Abnormality of the endocardium (HP:0004306)1.70855218
158Agitation (HP:0000713)1.70148514
159Abnormality of transition element cation homeostasis (HP:0011030)1.69676546
160Acne (HP:0001061)1.69279429
161Glomerulopathy (HP:0100820)1.68349517
162Wrist flexion contracture (HP:0001239)1.68223756
163Dysdiadochokinesis (HP:0002075)1.68014710
164Poikilocytosis (HP:0004447)1.67510059
165Abnormality of T cell physiology (HP:0011840)1.66345290
166Megalencephaly (HP:0001355)1.65713720
167Abnormality of salivation (HP:0100755)1.65510341
168Abnormality of the 4th metacarpal (HP:0010012)1.65449816
169Protrusio acetabuli (HP:0003179)1.64499411
170Hypercalciuria (HP:0002150)1.63825782
171Aortic valve stenosis (HP:0001650)1.63396488
172Megalocornea (HP:0000485)1.63149312
173Arnold-Chiari malformation (HP:0002308)1.62647276
174Alveolar cell carcinoma (HP:0006519)1.62521058
175Increased serum ferritin (HP:0003281)1.61986047
176Hydroxyprolinuria (HP:0003080)1.61848554
177Abnormality of proline metabolism (HP:0010907)1.61848554
178Neoplasm of the tracheobronchial system (HP:0100552)1.61613932
179Exotropia (HP:0000577)1.60965774
180Hemiparesis (HP:0001269)1.60898110
181Atonic seizures (HP:0010819)1.58800574
182Fetal akinesia sequence (HP:0001989)1.57885055
183Obstructive sleep apnea (HP:0002870)1.56910262
184Synostosis involving the elbow (HP:0003938)1.54758072
185Humeroradial synostosis (HP:0003041)1.54758072
186Facial hemangioma (HP:0000329)1.54611701
187Abnormality of the nasal septum (HP:0000419)1.53866240
188Aplasia of the musculature (HP:0100854)1.52947652
189Abnormality of the phalanges of the hallux (HP:0010057)1.52386256
190Flat capital femoral epiphysis (HP:0003370)1.52262250
191Generalized tonic-clonic seizures (HP:0002069)1.52125415
192Leiomyosarcoma (HP:0100243)1.51908255
193Uterine leiomyosarcoma (HP:0002891)1.51908255
194Increased circulating renin level (HP:0000848)1.50054323
195Gout (HP:0001997)1.46556590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.51109067
2CDK193.53937771
3MAP3K93.45837081
4TAOK33.26532260
5BLK3.20680073
6EPHA43.18515084
7LATS23.18128659
8MAP2K32.99696079
9MARK12.98307438
10IRAK42.87899627
11MAP3K42.82950646
12RIPK12.67067081
13KSR12.32905475
14LATS12.28293438
15MAP4K12.25695615
16PAK62.25146451
17GRK62.22530416
18NTRK22.22173041
19TNK22.21803539
20WNK32.17235579
21CSK2.07066329
22FES2.05797094
23NTRK32.04269212
24KSR22.00075058
25ZAP701.81334634
26ERN11.79139364
27TXK1.77193035
28BTK1.74222402
29MINK11.72572533
30MAP2K71.72260276
31MAPK131.64513060
32TYK21.63620009
33ERBB41.61322067
34PRKD31.60858104
35SYK1.59908261
36EPHB11.58279415
37HCK1.53252854
38KIT1.53011557
39TAOK11.52993984
40SIK31.49344429
41MAP3K111.49296846
42DMPK1.46252713
43IRAK11.45719369
44SGK21.44313298
45EPHB21.38841704
46LYN1.37956763
47TYRO31.37486132
48SGK2231.36567890
49SGK4941.36567890
50SIK21.34321654
51MATK1.28903767
52JAK21.27495766
53CAMK1G1.24981258
54BCR1.23906392
55IKBKE1.18333878
56MUSK1.17939557
57STK381.17828444
58MAP2K41.16991828
59JAK31.16250116
60PAK31.14811881
61FGFR21.14768511
62MAP3K61.13528829
63SGK31.11548684
64MAP3K31.10277348
65MAP3K131.09251628
66MAP3K11.09193417
67YES11.08632186
68TEC1.06960265
69DYRK31.05266079
70DDR21.04191044
71CAMKK21.03668700
72ERBB31.01889149
73RAF11.01103340
74NEK61.00912811
75PDGFRA0.99303062
76BMX0.96549007
77PLK20.95756174
78PINK10.95638502
79PTK60.93140937
80MAP3K140.92350037
81ADRBK10.91966056
82NTRK10.90563232
83LCK0.89698505
84CAMK1D0.88562517
85OXSR10.87972874
86HIPK20.84983741
87CDK50.84477681
88MAP4K20.81421266
89MAP3K70.80270894
90TGFBR20.79725337
91TESK20.79258708
92CASK0.78865770
93IKBKB0.77813732
94ADRBK20.77322342
95MARK30.74922756
96WNK10.72650764
97DYRK1B0.72132413
98TBK10.71901825
99DYRK20.71397598
100CAMKK10.71366334
101MARK20.70173921
102PLK40.69193619
103STK38L0.69174140
104CSNK1G20.68446157
105CSF1R0.67081845
106PRKCG0.66933498
107PDGFRB0.66795495
108FGR0.66425134
109ITK0.66147774
110PDK10.65077823
111ERBB20.65063017
112PIK3CG0.63685912
113CDK120.62540752
114MAP3K50.62159475
115NUAK10.61648206
116RPS6KA60.61603945
117RET0.60707012
118DYRK1A0.60573369
119DAPK20.60512777
120GRK70.60500852
121PRKD20.60455181
122STK110.59466502
123AKT30.59115040
124PRKCQ0.58957381
125BMPR20.58810305
126IRAK20.58480764
127FYN0.58475179
128EPHA30.58176076
129TLK10.57183427
130CDK180.56185483
131PRKAA10.55706657
132PDPK10.55562716
133FRK0.55546338
134SGK10.55084961
135CDK11A0.54131130
136MAP3K120.53979273
137JAK10.53970411
138RPS6KC10.53859016
139RPS6KL10.53859016
140PTK20.53766843
141MAP3K20.53271919
142FER0.52519704
143PRPF4B0.50765259
144CAMK40.50117051
145CAMK2A0.49345443
146PRKCZ0.48857542
147MAP2K10.48137061
148BRAF0.48076536
149FGFR10.47918277
150CDK80.47565171
151CDK150.47434777
152CAMK10.47343301
153CDC42BPA0.46692390
154PTK2B0.46669638
155STK30.46057414
156MAP2K60.45577826
157CSNK1A1L0.45137197
158RPS6KA20.45038314
159ACVR1B0.44435148
160FGFR30.44052791
161LRRK20.43501885
162PRKCH0.43292357
163PIM10.43021649
164CSNK1G10.42263108
165CDK90.41175814
166MOS0.38672854
167ABL20.38496284
168CDK140.38081187
169MAPK100.38029481
170LMTK20.36006434

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.60214269
2Nicotine addiction_Homo sapiens_hsa050332.58509845
3Leishmaniasis_Homo sapiens_hsa051402.47657600
4Staphylococcus aureus infection_Homo sapiens_hsa051502.13233674
5NOD-like receptor signaling pathway_Homo sapiens_hsa046211.99838919
6Malaria_Homo sapiens_hsa051441.96473860
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.91065395
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.89094256
9Tuberculosis_Homo sapiens_hsa051521.88066452
10Glutamatergic synapse_Homo sapiens_hsa047241.86484405
11B cell receptor signaling pathway_Homo sapiens_hsa046621.82431345
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80782213
13Synaptic vesicle cycle_Homo sapiens_hsa047211.69626779
14Chemokine signaling pathway_Homo sapiens_hsa040621.66342741
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64696445
16Acute myeloid leukemia_Homo sapiens_hsa052211.61745308
17Hematopoietic cell lineage_Homo sapiens_hsa046401.61548427
18Circadian entrainment_Homo sapiens_hsa047131.55353135
19Platelet activation_Homo sapiens_hsa046111.54184620
20Circadian rhythm_Homo sapiens_hsa047101.53264875
21Dorso-ventral axis formation_Homo sapiens_hsa043201.51408833
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50657436
23GnRH signaling pathway_Homo sapiens_hsa049121.49588992
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49273020
25GABAergic synapse_Homo sapiens_hsa047271.49028101
26Measles_Homo sapiens_hsa051621.48648897
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46800452
28Cocaine addiction_Homo sapiens_hsa050301.44768297
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.44245963
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42060488
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41882174
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36987764
33Long-term potentiation_Homo sapiens_hsa047201.36069265
34Morphine addiction_Homo sapiens_hsa050321.35519581
35Primary immunodeficiency_Homo sapiens_hsa053401.35442232
36Amphetamine addiction_Homo sapiens_hsa050311.34010857
37Olfactory transduction_Homo sapiens_hsa047401.33904315
38Axon guidance_Homo sapiens_hsa043601.32726966
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29819132
40T cell receptor signaling pathway_Homo sapiens_hsa046601.29539910
41Phagosome_Homo sapiens_hsa041451.27909456
42Regulation of autophagy_Homo sapiens_hsa041401.25735120
43Legionellosis_Homo sapiens_hsa051341.24809128
44Dopaminergic synapse_Homo sapiens_hsa047281.24103642
45Graft-versus-host disease_Homo sapiens_hsa053321.23314261
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22337850
47Long-term depression_Homo sapiens_hsa047301.22235154
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22158833
49ErbB signaling pathway_Homo sapiens_hsa040121.18693312
50Salivary secretion_Homo sapiens_hsa049701.17662702
51Vitamin B6 metabolism_Homo sapiens_hsa007501.15173441
52Ovarian steroidogenesis_Homo sapiens_hsa049131.14407747
53Allograft rejection_Homo sapiens_hsa053301.14073566
54Melanogenesis_Homo sapiens_hsa049161.13955433
55Gastric acid secretion_Homo sapiens_hsa049711.12736887
56Glioma_Homo sapiens_hsa052141.12696101
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12413642
58Choline metabolism in cancer_Homo sapiens_hsa052311.12258680
59Basal cell carcinoma_Homo sapiens_hsa052171.12151179
60Insulin secretion_Homo sapiens_hsa049111.12143671
61NF-kappa B signaling pathway_Homo sapiens_hsa040641.11614188
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11523502
63Influenza A_Homo sapiens_hsa051641.10526279
64Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10479274
65Non-small cell lung cancer_Homo sapiens_hsa052231.10294902
66Cholinergic synapse_Homo sapiens_hsa047251.09378230
67cAMP signaling pathway_Homo sapiens_hsa040241.09204942
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06938032
69Oocyte meiosis_Homo sapiens_hsa041141.06403737
70Gap junction_Homo sapiens_hsa045401.05688056
71Hedgehog signaling pathway_Homo sapiens_hsa043401.04301062
72Hippo signaling pathway_Homo sapiens_hsa043901.04065767
73Renin secretion_Homo sapiens_hsa049241.03202616
74Phospholipase D signaling pathway_Homo sapiens_hsa040721.01980124
75Nitrogen metabolism_Homo sapiens_hsa009101.01839787
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01646664
77Oxytocin signaling pathway_Homo sapiens_hsa049210.99562998
78Autoimmune thyroid disease_Homo sapiens_hsa053200.99087947
79Hepatitis B_Homo sapiens_hsa051610.97808356
80Toxoplasmosis_Homo sapiens_hsa051450.97352710
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96503652
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95910184
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95732238
84Fatty acid biosynthesis_Homo sapiens_hsa000610.94481417
85Wnt signaling pathway_Homo sapiens_hsa043100.94201679
86MAPK signaling pathway_Homo sapiens_hsa040100.94188595
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93964693
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93962277
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93793844
90Serotonergic synapse_Homo sapiens_hsa047260.93137137
91Hepatitis C_Homo sapiens_hsa051600.92668958
92Endometrial cancer_Homo sapiens_hsa052130.90852605
93Rap1 signaling pathway_Homo sapiens_hsa040150.89914771
94FoxO signaling pathway_Homo sapiens_hsa040680.88903502
95Ras signaling pathway_Homo sapiens_hsa040140.87779590
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87483582
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87475844
98Estrogen signaling pathway_Homo sapiens_hsa049150.87388557
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87360275
100TGF-beta signaling pathway_Homo sapiens_hsa043500.85635727
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85396185
102Herpes simplex infection_Homo sapiens_hsa051680.85327162
103Mineral absorption_Homo sapiens_hsa049780.84544826
104Taste transduction_Homo sapiens_hsa047420.83389145
105Chronic myeloid leukemia_Homo sapiens_hsa052200.83325606
106Prolactin signaling pathway_Homo sapiens_hsa049170.83189084
107mTOR signaling pathway_Homo sapiens_hsa041500.82889323
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82047984
109Renal cell carcinoma_Homo sapiens_hsa052110.81997338
110Colorectal cancer_Homo sapiens_hsa052100.80571089
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79756397
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.79728895
113Type II diabetes mellitus_Homo sapiens_hsa049300.78205254
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.78168350
115Endocytosis_Homo sapiens_hsa041440.78066547
116Pancreatic cancer_Homo sapiens_hsa052120.77697212
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77240109
118Salmonella infection_Homo sapiens_hsa051320.77212187
119Calcium signaling pathway_Homo sapiens_hsa040200.76690381
120Proteoglycans in cancer_Homo sapiens_hsa052050.75978087
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75765231
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74892559
123African trypanosomiasis_Homo sapiens_hsa051430.74770314
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72789959
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72628027
126Notch signaling pathway_Homo sapiens_hsa043300.72276137
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70235724
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69952637
129Antigen processing and presentation_Homo sapiens_hsa046120.69887076
130Pertussis_Homo sapiens_hsa051330.69555053
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.69002522
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68709620
133MicroRNAs in cancer_Homo sapiens_hsa052060.68350799
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67941615
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67902618
136Adherens junction_Homo sapiens_hsa045200.67336549
137Shigellosis_Homo sapiens_hsa051310.67133405
138Protein digestion and absorption_Homo sapiens_hsa049740.66869253
139Asthma_Homo sapiens_hsa053100.66630878
140TNF signaling pathway_Homo sapiens_hsa046680.66139116
141Type I diabetes mellitus_Homo sapiens_hsa049400.65820118
142Rheumatoid arthritis_Homo sapiens_hsa053230.65480186
143Focal adhesion_Homo sapiens_hsa045100.64126179
144VEGF signaling pathway_Homo sapiens_hsa043700.63714199
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.63570029
146cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63472409
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.62884644
148Butanoate metabolism_Homo sapiens_hsa006500.61689268
149Dilated cardiomyopathy_Homo sapiens_hsa054140.61632915
150Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61535744
151Leukocyte transendothelial migration_Homo sapiens_hsa046700.59374803
152Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59371474
153Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56935428
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56248601
155Thyroid hormone synthesis_Homo sapiens_hsa049180.55888286
156Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55871561
157Inositol phosphate metabolism_Homo sapiens_hsa005620.55692366
158Melanoma_Homo sapiens_hsa052180.53602985
159Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52989306
160Phototransduction_Homo sapiens_hsa047440.52975581
161Collecting duct acid secretion_Homo sapiens_hsa049660.52152903
162Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51888666
163Viral myocarditis_Homo sapiens_hsa054160.51784818
164Apoptosis_Homo sapiens_hsa042100.50885422
165Insulin resistance_Homo sapiens_hsa049310.50738618
166Pathways in cancer_Homo sapiens_hsa052000.49971484

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