RNF25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.16676748
2COPI coating of Golgi vesicle (GO:0048205)4.24452149
3Golgi transport vesicle coating (GO:0048200)4.24452149
4nuclear envelope reassembly (GO:0031468)4.16147003
5mitotic nuclear envelope reassembly (GO:0007084)4.16147003
6histone arginine methylation (GO:0034969)4.11322269
7protein maturation by protein folding (GO:0022417)3.95027179
8GDP-mannose metabolic process (GO:0019673)3.93000403
9positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.72347446
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69915428
11regulation of translational termination (GO:0006449)3.69519584
12NIK/NF-kappaB signaling (GO:0038061)3.66509254
13synaptic vesicle maturation (GO:0016188)3.63898557
14positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.63615725
15protein localization to endosome (GO:0036010)3.60632216
16negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.57736582
17sodium ion export (GO:0071436)3.45624810
18regulation of mammary gland epithelial cell proliferation (GO:0033599)3.42360178
19barbed-end actin filament capping (GO:0051016)3.41631562
20protein retention in ER lumen (GO:0006621)3.36516471
21amyloid precursor protein catabolic process (GO:0042987)3.35427488
22glucose 6-phosphate metabolic process (GO:0051156)3.35415327
23spliceosomal tri-snRNP complex assembly (GO:0000244)3.34098127
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.31676322
25regulation of cholesterol homeostasis (GO:2000188)3.31422867
26iron-sulfur cluster assembly (GO:0016226)3.29586689
27metallo-sulfur cluster assembly (GO:0031163)3.29586689
28mitochondrial fusion (GO:0008053)3.29424131
29histone H4-K5 acetylation (GO:0043981)3.26396592
30histone H4-K8 acetylation (GO:0043982)3.26396592
31negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.23050711
32positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.21367607
332-oxoglutarate metabolic process (GO:0006103)3.20965379
34oxaloacetate metabolic process (GO:0006107)3.20912053
35establishment of viral latency (GO:0019043)3.18336043
36tricarboxylic acid metabolic process (GO:0072350)3.17410697
37synaptic vesicle docking involved in exocytosis (GO:0016081)3.17332541
38alanine transport (GO:0032328)3.16319177
39regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 3.15928930
40lysine catabolic process (GO:0006554)3.15564774
41lysine metabolic process (GO:0006553)3.15564774
42pyrimidine-containing compound salvage (GO:0008655)3.15052772
43pyrimidine nucleoside salvage (GO:0043097)3.15052772
44NADH metabolic process (GO:0006734)3.14047493
45CDP-diacylglycerol metabolic process (GO:0046341)3.13128507
46activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.12875346
47positive regulation of triglyceride biosynthetic process (GO:0010867)3.11915932
48peptidyl-lysine dimethylation (GO:0018027)3.11119664
49regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.10829724
50virion assembly (GO:0019068)3.10334836
51protein insertion into membrane (GO:0051205)3.08812043
52macroautophagy (GO:0016236)3.05979705
53negative regulation of cell size (GO:0045792)3.02084573
54negative regulation of DNA-templated transcription, elongation (GO:0032785)3.02000755
55regulation of short-term neuronal synaptic plasticity (GO:0048172)3.01450717
56locomotory exploration behavior (GO:0035641)3.01219724
57endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.99031761
58peptidyl-arginine omega-N-methylation (GO:0035247)2.98734441
59aspartate family amino acid catabolic process (GO:0009068)2.97878885
60binding of sperm to zona pellucida (GO:0007339)2.97744526
61UV protection (GO:0009650)2.95202248
62positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.94322094
63positive regulation of nuclease activity (GO:0032075)2.93803554
64layer formation in cerebral cortex (GO:0021819)2.92141180
65regulation of release of cytochrome c from mitochondria (GO:0090199)2.92139601
66mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.91941577
67alpha-linolenic acid metabolic process (GO:0036109)2.91586327
68activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.89863731
69activation of protein kinase A activity (GO:0034199)2.89347516
70cysteine metabolic process (GO:0006534)2.88905760
71histone H4-K16 acetylation (GO:0043984)2.88091667
72positive regulation of fatty acid biosynthetic process (GO:0045723)2.85699442
73gluconeogenesis (GO:0006094)2.85595816
74peptidyl-arginine N-methylation (GO:0035246)2.85535939
75peptidyl-arginine methylation (GO:0018216)2.85535939
76positive regulation of synapse maturation (GO:0090129)2.85058669
77cerebellar Purkinje cell layer development (GO:0021680)2.84957358
78dicarboxylic acid biosynthetic process (GO:0043650)2.84220952
79regulation of ARF protein signal transduction (GO:0032012)2.83101305
80negative regulation of sodium ion transport (GO:0010766)2.82320743
81negative regulation of microtubule polymerization (GO:0031115)2.81933694
82viral protein processing (GO:0019082)2.81727509
83regulation of inclusion body assembly (GO:0090083)2.81681578
84response to misfolded protein (GO:0051788)2.80985927
85hexose biosynthetic process (GO:0019319)2.80752756
86sperm motility (GO:0030317)2.80191299
87de novo posttranslational protein folding (GO:0051084)2.80087785
88regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.78851524
89positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.78851524
90CDP-diacylglycerol biosynthetic process (GO:0016024)2.78845344
91diacylglycerol metabolic process (GO:0046339)2.77212796
92formation of translation preinitiation complex (GO:0001731)2.76828501
93glutamate metabolic process (GO:0006536)2.76348444
94cell communication by electrical coupling (GO:0010644)2.75181982
95T cell apoptotic process (GO:0070231)2.74379917
964-hydroxyproline metabolic process (GO:0019471)2.74188271
97Arp2/3 complex-mediated actin nucleation (GO:0034314)2.73012455
98retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.72539509
99stress fiber assembly (GO:0043149)2.72444423
100glycolytic process (GO:0006096)2.70385140
101L-phenylalanine metabolic process (GO:0006558)2.70353927
102erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.70353927
103positive regulation of mitochondrion organization (GO:0010822)2.70015896
104sperm-egg recognition (GO:0035036)2.68977703
105cholesterol catabolic process (GO:0006707)2.68746729
106sterol catabolic process (GO:0016127)2.68746729
107neurotransmitter secretion (GO:0007269)2.67843804
108cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.67610278
109skin morphogenesis (GO:0043589)2.67286267
110pentose-phosphate shunt (GO:0006098)2.63772963
111de novo protein folding (GO:0006458)2.62024470
112neuromuscular process controlling posture (GO:0050884)2.61207357
113negative regulation of inclusion body assembly (GO:0090084)2.60997505
114regulation of nuclease activity (GO:0032069)2.60988497
115apoptotic process involved in morphogenesis (GO:0060561)2.60486203
116proline biosynthetic process (GO:0006561)2.59722040
117establishment of integrated proviral latency (GO:0075713)2.59013208
118vesicle coating (GO:0006901)2.58876632
119proteasome assembly (GO:0043248)2.58820049
120amino sugar catabolic process (GO:0046348)2.57435709
121monosaccharide biosynthetic process (GO:0046364)2.57431932
122regulation of translational fidelity (GO:0006450)2.56962596
123pinocytosis (GO:0006907)2.54919523
1243-UTR-mediated mRNA stabilization (GO:0070935)2.54828805
125fructose metabolic process (GO:0006000)2.53565988
126maternal placenta development (GO:0001893)2.53123046
127intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.52247705
128chaperone-mediated protein complex assembly (GO:0051131)2.51747215
129erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.51717919
130L-phenylalanine catabolic process (GO:0006559)2.51717919
131cellular sodium ion homeostasis (GO:0006883)2.50346388
132activation of MAPKKK activity (GO:0000185)2.50271462
133glutamate secretion (GO:0014047)2.49525178
134proline transport (GO:0015824)2.49250851
135mannose metabolic process (GO:0006013)2.48358568
136cell-cell recognition (GO:0009988)2.47964867
137sulfur amino acid catabolic process (GO:0000098)2.47739508
138endoplasmic reticulum unfolded protein response (GO:0030968)2.47352591
139regulation of protein heterodimerization activity (GO:0043497)2.46640395
140sexual reproduction (GO:0019953)2.46523917
141peptidyl-arginine modification (GO:0018195)2.45765341
142urea cycle (GO:0000050)2.45713791
143urea metabolic process (GO:0019627)2.45713791
144regulation of mitochondrion organization (GO:0010821)2.45177176
145positive regulation of lymphocyte apoptotic process (GO:0070230)2.44921718
146succinate metabolic process (GO:0006105)2.44684770
147cellular modified amino acid catabolic process (GO:0042219)2.44189615
148modulation by symbiont of host cellular process (GO:0044068)2.44160988
149regulation of defense response to virus by virus (GO:0050690)2.44103028
150cellular response to unfolded protein (GO:0034620)2.43988131
151positive regulation of protein homooligomerization (GO:0032464)2.43874908
152positive regulation of T cell apoptotic process (GO:0070234)2.43649050
153negative regulation of sterol transport (GO:0032372)2.43523116
154negative regulation of cholesterol transport (GO:0032375)2.43523116
155cellular response to topologically incorrect protein (GO:0035967)2.43499108
156antigen processing and presentation via MHC class Ib (GO:0002475)2.43110869
157valine metabolic process (GO:0006573)2.42846685
158cytoskeletal anchoring at plasma membrane (GO:0007016)2.42217799
159folic acid metabolic process (GO:0046655)2.41722593
160folic acid-containing compound biosynthetic process (GO:0009396)2.41721768
161L-alpha-amino acid transmembrane transport (GO:1902475)2.40595493
162negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.40331748
163adherens junction assembly (GO:0034333)2.39407693
164negative regulation of ligase activity (GO:0051352)2.39100859
165negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.39100859
166positive regulation of protein sumoylation (GO:0033235)2.37763057
167negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.37507647
168pentose metabolic process (GO:0019321)2.35539154
169regulation of exit from mitosis (GO:0007096)2.35455723
170regulation of chromatin binding (GO:0035561)2.35389626
171positive regulation of mitochondrial fission (GO:0090141)2.35229361
172mitochondrial DNA metabolic process (GO:0032042)2.34802297
173ncRNA 3-end processing (GO:0043628)2.34477034
174modulation by virus of host process (GO:0019054)2.34082791
175basement membrane organization (GO:0071711)2.32916359
176cell-substrate adherens junction assembly (GO:0007045)2.32103513
177focal adhesion assembly (GO:0048041)2.32103513
178NADPH regeneration (GO:0006740)2.29759424
179cellular response to arsenic-containing substance (GO:0071243)2.29625177
180lymphocyte apoptotic process (GO:0070227)2.29094144
181retrograde transport, endosome to Golgi (GO:0042147)2.28807822
182positive regulation of protein oligomerization (GO:0032461)2.26291700
183antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.23521921

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.45048954
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.81820137
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81485935
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.66654510
5MYC_22102868_ChIP-Seq_BL_Human2.54158721
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.51934517
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46052369
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.45210751
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41964402
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.39810362
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24298574
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22403364
13LXR_22292898_ChIP-Seq_THP-1_Human2.20735811
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.13865699
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.12409085
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.03219662
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02421902
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01747811
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00216152
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95651936
21ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95306601
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95284645
23ZNF263_19887448_ChIP-Seq_K562_Human1.95217461
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.89160586
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.88254226
26XRN2_22483619_ChIP-Seq_HELA_Human1.82149058
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.80508683
28P68_20966046_ChIP-Seq_HELA_Human1.80361987
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79700924
30* GABP_19822575_ChIP-Seq_HepG2_Human1.77552548
31DCP1A_22483619_ChIP-Seq_HELA_Human1.75476414
32SMC4_20622854_ChIP-Seq_HELA_Human1.74242825
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72942037
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.71543315
35* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69765835
36KDM2B_26808549_Chip-Seq_DND41_Human1.69087838
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68074221
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65377848
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65192672
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.64209280
41ELF1_20517297_ChIP-Seq_JURKAT_Human1.63277247
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61245315
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.61161906
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59413583
45CLOCK_20551151_ChIP-Seq_293T_Human1.58960029
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58764722
47* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56791310
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.55715672
49VDR_21846776_ChIP-Seq_THP-1_Human1.55278384
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54902623
51BCL6_27268052_Chip-Seq_Bcells_Human1.54863811
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.54132172
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53239920
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.53091716
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52533636
56TCF7_22412390_ChIP-Seq_EML_Mouse1.49932151
57TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.49488636
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49013384
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48682761
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48413859
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47731554
62BCOR_27268052_Chip-Seq_Bcells_Human1.45981078
63* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43300115
64RACK7_27058665_Chip-Seq_MCF-7_Human1.42612862
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40786575
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.40626154
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40072159
68CREB1_26743006_Chip-Seq_LNCaP_Human1.39395417
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38544950
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38431933
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37802749
72LXR_22158963_ChIP-Seq_LIVER_Mouse1.37667566
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37207066
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.36980427
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.33810256
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33537142
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32353625
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.31701340
79PHF8_20622854_ChIP-Seq_HELA_Human1.31545496
80* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31517177
81* GABP_17652178_ChIP-ChIP_JURKAT_Human1.30665596
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29882086
83CIITA_25753668_ChIP-Seq_RAJI_Human1.29858652
84TFEB_21752829_ChIP-Seq_HELA_Human1.29845013
85E2F7_22180533_ChIP-Seq_HELA_Human1.29754945
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29047208
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28871073
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.27828267
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25804335
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25410456
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25346560
92ATF3_27146783_Chip-Seq_COLON_Human1.25307213
93EZH2_22144423_ChIP-Seq_EOC_Human1.24792870
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24579125
95YY1_22570637_ChIP-Seq_MALME-3M_Human1.23858367
96CTCF_21964334_ChIP-Seq_BJAB-B_Human1.22836822
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22312084
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22122467
99FOXP1_21924763_ChIP-Seq_HESCs_Human1.21588309
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20735216
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20669132
102TP53_22127205_ChIP-Seq_IMR90_Human1.19034276
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18986388
104MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18386003
105CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18000405
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17424605
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17256698
108E2F1_20622854_ChIP-Seq_HELA_Human1.17041155
109MAF_26560356_Chip-Seq_TH1_Human1.16319757
110ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16142334
111KDM2B_26808549_Chip-Seq_K562_Human1.15275208
112MAF_26560356_Chip-Seq_TH2_Human1.14783598
113TP63_22573176_ChIP-Seq_HFKS_Human1.14103955
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13615802
115EGR1_19374776_ChIP-ChIP_THP-1_Human1.12165655
116ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12087025
117NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11861679
118KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11681924
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10521280
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10252186
121UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09910186
122* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09365528
123REST_18959480_ChIP-ChIP_MESCs_Mouse1.09324737
124TET1_21490601_ChIP-Seq_MESCs_Mouse1.09009081
125SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08665430
126CTCF_20526341_ChIP-Seq_ESCs_Human1.07469821
127KDM2B_26808549_Chip-Seq_JURKAT_Human1.07098916
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05281036
129CTCF_21964334_Chip-Seq_Bcells_Human1.04568943
130CTCF_27219007_Chip-Seq_Bcells_Human1.04103373
131TTF2_22483619_ChIP-Seq_HELA_Human1.03774627
132UTX_26944678_Chip-Seq_JUKART_Human1.03691000
133NANOG_21062744_ChIP-ChIP_HESCs_Human1.03464366
134* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03149131
135CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03081509
136ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02797903
137SA1_27219007_Chip-Seq_Bcells_Human1.02789493
138P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01887796
139PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01861962
140TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01777421
141KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01461707
142CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00045005
143TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99945692
144MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99687985
145FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99197098
146DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98908402
147ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98526101
148CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98454633
149CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97536415
150OCT4_19829295_ChIP-Seq_ESCs_Human0.97510552
151FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97242678
152KDM5A_27292631_Chip-Seq_BREAST_Human0.96441317
153CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95936161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.21963224
2MP0008260_abnormal_autophagy3.98973251
3MP0009840_abnormal_foam_cell3.33032256
4MP0008438_abnormal_cutaneous_collagen3.13453063
5MP0005365_abnormal_bile_salt2.99790098
6MP0003705_abnormal_hypodermis_morpholog2.78655068
7MP0005410_abnormal_fertilization2.74201869
8MP0005083_abnormal_biliary_tract2.69536819
9MP0005451_abnormal_body_composition2.68636698
10MP0003329_amyloid_beta_deposits2.68490029
11MP0002139_abnormal_hepatobiliary_system2.60210573
12MP0005360_urolithiasis2.49011161
13MP0002877_abnormal_melanocyte_morpholog2.45394121
14MP0002909_abnormal_adrenal_gland2.43643480
15MP0010234_abnormal_vibrissa_follicle2.37380197
16MP0008961_abnormal_basal_metabolism2.17474561
17MP0003566_abnormal_cell_adhesion2.11533271
18MP0000858_altered_metastatic_potential2.09331188
19MP0002653_abnormal_ependyma_morphology2.03864931
20MP0001542_abnormal_bone_strength1.98670443
21MP0003436_decreased_susceptibility_to1.97641819
22MP0003283_abnormal_digestive_organ1.96971454
23MP0000604_amyloidosis1.95597764
24MP0003635_abnormal_synaptic_transmissio1.89247932
25MP0005257_abnormal_intraocular_pressure1.87691940
26MP0003123_paternal_imprinting1.79335937
27MP0005085_abnormal_gallbladder_physiolo1.71908179
28MP0010329_abnormal_lipoprotein_level1.69411709
29MP0003221_abnormal_cardiomyocyte_apopto1.68475526
30MP0004233_abnormal_muscle_weight1.67404061
31MP0003453_abnormal_keratinocyte_physiol1.66809573
32MP0000013_abnormal_adipose_tissue1.66701019
33MP0010030_abnormal_orbit_morphology1.64366064
34MP0000343_altered_response_to1.61669350
35MP0009333_abnormal_splenocyte_physiolog1.61188528
36MP0004858_abnormal_nervous_system1.60110551
37MP0003693_abnormal_embryo_hatching1.58782859
38MP0004130_abnormal_muscle_cell1.55371304
39MP0005332_abnormal_amino_acid1.50922470
40MP0001348_abnormal_lacrimal_gland1.49629639
41MP0004510_myositis1.47713968
42MP0004272_abnormal_basement_membrane1.47696940
43MP0003279_aneurysm1.47304160
44MP0002822_catalepsy1.45565952
45MP0002254_reproductive_system_inflammat1.45188257
46MP0008875_abnormal_xenobiotic_pharmacok1.41489813
47MP0000751_myopathy1.41281431
48MP0002269_muscular_atrophy1.39384143
49MP0003646_muscle_fatigue1.38991902
50MP0003091_abnormal_cell_migration1.38930015
51MP0005501_abnormal_skin_physiology1.37350463
52MP0003191_abnormal_cellular_cholesterol1.36506521
53MP0000733_abnormal_muscle_development1.36139883
54MP0008932_abnormal_embryonic_tissue1.36096072
55MP0002089_abnormal_postnatal_growth/wei1.36021781
56MP0002060_abnormal_skin_morphology1.31796241
57MP0000747_muscle_weakness1.31246786
58MP0005058_abnormal_lysosome_morphology1.30998661
59MP0001243_abnormal_dermal_layer1.28149470
60MP0000767_abnormal_smooth_muscle1.26903105
61MP0003656_abnormal_erythrocyte_physiolo1.26354938
62MP0003111_abnormal_nucleus_morphology1.24387248
63MP0009780_abnormal_chondrocyte_physiolo1.22464112
64MP0009053_abnormal_anal_canal1.21557979
65MP0002064_seizures1.20461976
66MP0002063_abnormal_learning/memory/cond1.20356837
67MP0004270_analgesia1.20325642
68MP0010368_abnormal_lymphatic_system1.18495647
69MP0003172_abnormal_lysosome_physiology1.17573607
70MP0001666_abnormal_nutrient_absorption1.17131080
71MP0003075_altered_response_to1.17049976
72MP0000358_abnormal_cell_content/1.15215949
73MP0009046_muscle_twitch1.12989888
74MP0004947_skin_inflammation1.12686917
75MP0003698_abnormal_male_reproductive1.12022865
76MP0008007_abnormal_cellular_replicative1.11838623
77MP0003077_abnormal_cell_cycle1.11524051
78MP0005621_abnormal_cell_physiology1.10439003
79MP0003186_abnormal_redox_activity1.09802706
80MP0000609_abnormal_liver_physiology1.09400791
81MP0001929_abnormal_gametogenesis1.09077570
82MP0000759_abnormal_skeletal_muscle1.08914768
83MP0002234_abnormal_pharynx_morphology1.08751319
84MP0005167_abnormal_blood-brain_barrier1.08705970
85MP0002118_abnormal_lipid_homeostasis1.08295200
86MP0004885_abnormal_endolymph1.07986602
87MP0000490_abnormal_crypts_of1.07899796
88MP0001853_heart_inflammation1.06616522
89MP0003300_gastrointestinal_ulcer1.04329540
90MP0005220_abnormal_exocrine_pancreas1.04247915
91MP0005384_cellular_phenotype1.04028300
92MP0003763_abnormal_thymus_physiology1.03472171
93MP0003879_abnormal_hair_cell1.02255451
94MP0000313_abnormal_cell_death1.00369929
95MP0009745_abnormal_behavioral_response0.99987498
96MP0001216_abnormal_epidermal_layer0.99253363
97MP0003786_premature_aging0.99204315
98MP0001915_intracranial_hemorrhage0.99148436
99MP0005187_abnormal_penis_morphology0.99004367
100MP0002161_abnormal_fertility/fecundity0.98587684
101MP0005025_abnormal_response_to0.98571798
102MP0002080_prenatal_lethality0.98510797
103MP0001533_abnormal_skeleton_physiology0.97493931
104MP0001765_abnormal_ion_homeostasis0.96417432
105MP0006035_abnormal_mitochondrial_morpho0.96232733
106MP0005670_abnormal_white_adipose0.95611147
107MP0009785_altered_susceptibility_to0.95138875
108MP0003868_abnormal_feces_composition0.94998173
109MP0004811_abnormal_neuron_physiology0.94993095
110MP0003638_abnormal_response/metabolism_0.93987223
111MP0005319_abnormal_enzyme/_coenzyme0.93802006
112MP0002078_abnormal_glucose_homeostasis0.93375258
113MP0001440_abnormal_grooming_behavior0.93136989
114MP0000750_abnormal_muscle_regeneration0.92974869
115MP0005330_cardiomyopathy0.92543562
116MP0000350_abnormal_cell_proliferation0.92348365
117MP0001958_emphysema0.90676391
118MP0002419_abnormal_innate_immunity0.90222471
119MP0002734_abnormal_mechanical_nocicepti0.89731777
120MP0003806_abnormal_nucleotide_metabolis0.88813642
121MP0005000_abnormal_immune_tolerance0.87840983
122MP0001849_ear_inflammation0.87088282
123MP0003448_altered_tumor_morphology0.86748566
124MP0003633_abnormal_nervous_system0.86011935
125MP0001756_abnormal_urination0.84100251
126MP0000537_abnormal_urethra_morphology0.84063723
127MP0003959_abnormal_lean_body0.83362105
128MP0006082_CNS_inflammation0.83346501
129MP0010352_gastrointestinal_tract_polyps0.82451917
130MP0001730_embryonic_growth_arrest0.82033987
131MP0002572_abnormal_emotion/affect_behav0.82020737
132MP0005584_abnormal_enzyme/coenzyme_acti0.81939397
133MP0008877_abnormal_DNA_methylation0.81790044
134MP0009643_abnormal_urine_homeostasis0.81159282
135MP0001727_abnormal_embryo_implantation0.80471815
136MP0002405_respiratory_system_inflammati0.80433634
137MP0001346_abnormal_lacrimal_gland0.79654874
138MP0002733_abnormal_thermal_nociception0.79385329
139MP0000003_abnormal_adipose_tissue0.78904374
140MP0002148_abnormal_hypersensitivity_rea0.78510817
141MP0001944_abnormal_pancreas_morphology0.78436914
142MP0008770_decreased_survivor_rate0.78169898
143MP0005390_skeleton_phenotype0.77447138
144MP0002837_dystrophic_cardiac_calcinosis0.76870558
145MP0002723_abnormal_immune_serum0.75826755
146MP0000703_abnormal_thymus_morphology0.74978441
147MP0001501_abnormal_sleep_pattern0.74945742
148MP0000762_abnormal_tongue_morphology0.74910042
149MP0003303_peritoneal_inflammation0.73726062
150MP0008874_decreased_physiological_sensi0.73694809
151MP0005508_abnormal_skeleton_morphology0.73631484
152MP0005623_abnormal_meninges_morphology0.72678316
153MP0006036_abnormal_mitochondrial_physio0.72452162
154MP0000598_abnormal_liver_morphology0.71991951
155MP0009672_abnormal_birth_weight0.71773737
156MP0005193_abnormal_anterior_eye0.71580980
157MP0005023_abnormal_wound_healing0.69624138
158MP0002069_abnormal_eating/drinking_beha0.69575386
159MP0002420_abnormal_adaptive_immunity0.69498944
160MP0000955_abnormal_spinal_cord0.69102526
161MP0002249_abnormal_larynx_morphology0.69047190
162MP0005448_abnormal_energy_balance0.68656134
163MP0002429_abnormal_blood_cell0.68460828
164MP0001819_abnormal_immune_cell0.67855342
165MP0000749_muscle_degeneration0.67843592
166MP0001970_abnormal_pain_threshold0.67809560
167MP0005464_abnormal_platelet_physiology0.67686038
168MP0001968_abnormal_touch/_nociception0.67605950
169MP0008872_abnormal_physiological_respon0.67458485
170MP0004957_abnormal_blastocyst_morpholog0.67185594
171MP0000639_abnormal_adrenal_gland0.66997443
172MP0009764_decreased_sensitivity_to0.66906378
173MP0005076_abnormal_cell_differentiation0.66808265
174MP0008569_lethality_at_weaning0.66568073

Predicted human phenotypes

RankGene SetZ-score
1Vertebral compression fractures (HP:0002953)4.79182381
2Premature rupture of membranes (HP:0001788)4.17170025
3Gout (HP:0001997)3.83320531
4Abnormality of the lower motor neuron (HP:0002366)3.79651222
5Global brain atrophy (HP:0002283)3.34272603
6Deep venous thrombosis (HP:0002625)3.24653384
7Hand muscle atrophy (HP:0009130)3.10278527
8Trismus (HP:0000211)3.01760263
9Upper limb amyotrophy (HP:0009129)3.00736662
10Distal upper limb amyotrophy (HP:0007149)3.00736662
11Myokymia (HP:0002411)2.97971184
12Cerebral aneurysm (HP:0004944)2.86158343
13Abnormality of glycolipid metabolism (HP:0010969)2.77721354
14Abnormality of liposaccharide metabolism (HP:0010968)2.77721354
15Abnormality of glycosphingolipid metabolism (HP:0004343)2.77721354
16Abnormality of aromatic amino acid family metabolism (HP:0004338)2.77214361
17Hyperacusis (HP:0010780)2.75483980
18Nasal polyposis (HP:0100582)2.73825410
19Spastic diplegia (HP:0001264)2.70957973
20Xanthomatosis (HP:0000991)2.70159003
21Male infertility (HP:0003251)2.69063258
22Long toe (HP:0010511)2.68301194
23Infertility (HP:0000789)2.67025724
24Ragged-red muscle fibers (HP:0003200)2.66414663
25Entropion (HP:0000621)2.57729115
26Microvesicular hepatic steatosis (HP:0001414)2.57592844
27Cholecystitis (HP:0001082)2.57345482
28Abnormal gallbladder physiology (HP:0012438)2.57345482
29Rough bone trabeculation (HP:0100670)2.55822876
30Limb-girdle muscle atrophy (HP:0003797)2.52290767
31Enlarged penis (HP:0000040)2.52255462
32Spinal rigidity (HP:0003306)2.50372403
33Abnormality of the nasal mucosa (HP:0000433)2.48798322
34Short nail (HP:0001799)2.45064066
35Cervical subluxation (HP:0003308)2.44299663
36Resting tremor (HP:0002322)2.44174947
37Shoulder girdle muscle weakness (HP:0003547)2.42953036
38Difficulty climbing stairs (HP:0003551)2.41539467
39Radial bowing (HP:0002986)2.41422508
40Prolonged neonatal jaundice (HP:0006579)2.41211337
41Increased connective tissue (HP:0009025)2.40910698
42Hemiplegia (HP:0002301)2.38656855
43Delusions (HP:0000746)2.37890895
44Insomnia (HP:0100785)2.37169779
45Back pain (HP:0003418)2.36669094
46Abnormality of the Achilles tendon (HP:0005109)2.36371732
47Long palpebral fissure (HP:0000637)2.32657995
48Ketosis (HP:0001946)2.31999502
49Axonal loss (HP:0003447)2.31870226
50Torticollis (HP:0000473)2.29392612
51Visual hallucinations (HP:0002367)2.28487833
52Squamous cell carcinoma (HP:0002860)2.27235174
53Apathy (HP:0000741)2.26071824
54Postural instability (HP:0002172)2.25916881
55Striae distensae (HP:0001065)2.25489701
56Supranuclear gaze palsy (HP:0000605)2.25261260
57Achilles tendon contracture (HP:0001771)2.24874269
58Distal lower limb amyotrophy (HP:0008944)2.24832676
59Abnormality of dentin (HP:0010299)2.22955251
60Upper motor neuron abnormality (HP:0002127)2.21216546
61Pelvic girdle muscle weakness (HP:0003749)2.20245034
62Atrophic scars (HP:0001075)2.19252424
63Diminished motivation (HP:0000745)2.19030842
64Hypercortisolism (HP:0001578)2.18700096
65Sensorimotor neuropathy (HP:0007141)2.18470653
66Biconcave vertebral bodies (HP:0004586)2.18355625
67Centrally nucleated skeletal muscle fibers (HP:0003687)2.17810894
68Upper limb muscle weakness (HP:0003484)2.16546308
69Abnormality of the umbilical cord (HP:0010881)2.14557008
70Nonimmune hydrops fetalis (HP:0001790)2.13698393
71Abnormality of the musculature of the pelvis (HP:0001469)2.12821325
72Abnormality of the hip-girdle musculature (HP:0001445)2.12821325
73Distal lower limb muscle weakness (HP:0009053)2.12788923
74Mitral regurgitation (HP:0001653)2.10461616
75Neuronal loss in central nervous system (HP:0002529)2.07579298
76Generalized hyperpigmentation (HP:0007440)2.07171722
77Myopathic facies (HP:0002058)2.06297334
78Neoplasm of the heart (HP:0100544)2.06198109
79Depression (HP:0000716)2.06143693
80Brushfield spots (HP:0001088)2.05642006
81Craniofacial dystonia (HP:0012179)2.05319695
82Nuclear cataract (HP:0100018)2.02893155
83Hypoalphalipoproteinemia (HP:0003233)2.02296097
84Progressive muscle weakness (HP:0003323)2.00973107
85Impaired pain sensation (HP:0007328)2.00908259
86Abnormality of pain sensation (HP:0010832)2.00908259
87Fatigue (HP:0012378)2.00230772
88Focal dystonia (HP:0004373)2.00022227
89Protrusio acetabuli (HP:0003179)1.99355760
90Cerebral inclusion bodies (HP:0100314)1.98426770
91Tetraplegia (HP:0002445)1.97535987
92Polygenic inheritance (HP:0010982)1.97160650
93Impaired vibration sensation in the lower limbs (HP:0002166)1.97007711
94Chronic bronchitis (HP:0004469)1.96695416
95Abnormal trabecular bone morphology (HP:0100671)1.96142805
96Broad distal phalanx of finger (HP:0009836)1.95688520
97Generalized amyotrophy (HP:0003700)1.95237751
98Elbow flexion contracture (HP:0002987)1.94062681
99Increased variability in muscle fiber diameter (HP:0003557)1.93971460
100Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.93645962
101Peripheral hypomyelination (HP:0007182)1.93531871
102Bladder diverticulum (HP:0000015)1.92578513
103Ulnar deviation of the wrist (HP:0003049)1.92366250
104Rigidity (HP:0002063)1.92267482
105Neonatal onset (HP:0003623)1.90622205
106Ketoacidosis (HP:0001993)1.90423724
107Loss of speech (HP:0002371)1.89887327
108Poor suck (HP:0002033)1.88564099
109Abnormality of macrophages (HP:0004311)1.87751582
110Ulnar bowing (HP:0003031)1.86605414
111Abnormality of skeletal muscle fiber size (HP:0012084)1.86352258
112Status epilepticus (HP:0002133)1.86029511
113Bowed forearm bones (HP:0003956)1.85880796
114Bowing of the arm (HP:0006488)1.85880796
115Hyperparathyroidism (HP:0000843)1.85669701
116Dysostosis multiplex (HP:0000943)1.84514839
117Myoglobinuria (HP:0002913)1.83054498
118Asymmetric septal hypertrophy (HP:0001670)1.82624531
119Limb-girdle muscle weakness (HP:0003325)1.82612432
120Personality changes (HP:0000751)1.82538951
121Late onset (HP:0003584)1.80696231
122Hyperlipoproteinemia (HP:0010980)1.79545509
123Short clavicles (HP:0000894)1.79128590
124Abnormality of the motor neurons (HP:0002450)1.78283724
125Abnormal neuron morphology (HP:0012757)1.78283724
126Pointed chin (HP:0000307)1.78092653
127Bundle branch block (HP:0011710)1.77163883
128Hyperammonemia (HP:0001987)1.76759327
129Abnormality of glycolysis (HP:0004366)1.76715727
130Cutaneous melanoma (HP:0012056)1.76064488
131Abnormalities of placenta or umbilical cord (HP:0001194)1.75474481
132Abnormality of sulfur amino acid metabolism (HP:0004339)1.74841439
133Fragile skin (HP:0001030)1.74785732
134Mildly elevated creatine phosphokinase (HP:0008180)1.73868799
135Severe short stature (HP:0003510)1.73162508
136Abnormality of mucopolysaccharide metabolism (HP:0011020)1.72760884
137Abnormality of polysaccharide metabolism (HP:0011012)1.72760884
138Abnormality of glycosaminoglycan metabolism (HP:0004371)1.72760884
139Hypertensive crisis (HP:0100735)1.72598140
140Hypolipoproteinemia (HP:0010981)1.71869871
141Malnutrition (HP:0004395)1.71852446
142Genu recurvatum (HP:0002816)1.71796476
143Joint stiffness (HP:0001387)1.71773506
144EMG: neuropathic changes (HP:0003445)1.71744149
145Abnormality of glycine metabolism (HP:0010895)1.71643018
146Abnormality of serine family amino acid metabolism (HP:0010894)1.71643018
147Aneurysm (HP:0002617)1.71200235
148Natal tooth (HP:0000695)1.71054388
149Hepatosplenomegaly (HP:0001433)1.70968338
150Turricephaly (HP:0000262)1.70898586
151Reticulocytosis (HP:0001923)1.70893490
152Reduced subcutaneous adipose tissue (HP:0003758)1.70433447
153Abnormality of the fetal cardiovascular system (HP:0010948)1.69084216
154Abnormal umbilical cord blood vessels (HP:0011403)1.69084216
155Single umbilical artery (HP:0001195)1.69084216
156Hyperglycinuria (HP:0003108)1.69037457
157Neurofibrillary tangles (HP:0002185)1.69025294
158Secondary amenorrhea (HP:0000869)1.68175503
159Cholelithiasis (HP:0001081)1.67739055
160Poikiloderma (HP:0001029)1.66950544
161Aplasia/Hypoplasia of the clavicles (HP:0006710)1.66370661
162Ankle contracture (HP:0006466)1.66064344
163CNS hypomyelination (HP:0003429)1.65514777
164Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65497014
165Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65445214
166Increased cerebral lipofuscin (HP:0011813)1.64986217
167Atrioventricular block (HP:0001678)1.64673320
168Ventricular fibrillation (HP:0001663)1.64664453
169Abnormality of monocarboxylic acid metabolism (HP:0010996)1.64579643
170Athetosis (HP:0002305)1.64368074
171Decreased activity of mitochondrial respiratory chain (HP:0008972)1.63836619
172Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.63836619
173Type II lissencephaly (HP:0007260)1.63245535
174Elfin facies (HP:0004428)1.62685339
175Intellectual disability, profound (HP:0002187)1.62175089
176Increased density of long bones (HP:0006392)1.62032717
177Hypsarrhythmia (HP:0002521)1.60991485
178Stroke (HP:0001297)1.60915991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.27743056
2TRIB33.90261978
3MAP3K93.24674252
4NME23.23792205
5PIM23.07848011
6SMG13.06694726
7PKN22.83069651
8IRAK32.71932130
9KSR22.67029276
10ERN12.50308197
11BCKDK2.31767174
12MAPKAPK32.30666847
13PRKD32.24092776
14PDK32.22104847
15PDK42.22104847
16SCYL22.16183027
17VRK22.02851889
18TAOK11.99165819
19LIMK11.97323406
20SIK31.96639675
21NEK11.94907428
22SIK11.71300405
23PAK61.65214731
24LRRK21.59225534
25PRPF4B1.57484062
26LATS21.50821637
27SIK21.48193832
28KDR1.47706767
29ICK1.41120937
30MAP3K51.39929754
31ARAF1.36673465
32FLT31.34802328
33MAP3K61.32501760
34CAMKK11.31803946
35NTRK31.31669579
36MAP3K41.29955728
37ALK1.29066762
38TAOK21.28296360
39PRKD21.28149850
40TESK11.26776364
41TBK11.26494867
42SRPK11.26070730
43CDK191.24874826
44RPS6KB21.24593594
45TSSK61.23752293
46TTN1.20408224
47AURKA1.10364404
48BUB11.07927577
49MAP2K41.06995933
50RAF11.06669920
51STK381.05962347
52EPHA41.04997584
53MAP2K71.04896389
54NTRK11.04611342
55PTK61.04208486
56KSR11.03730557
57NEK21.03565505
58RET1.02767224
59IRAK21.00830577
60PINK10.97588693
61CDK120.97058864
62IRAK40.92284289
63MAP3K110.90834657
64TYRO30.90815899
65MAP3K30.89615362
66DAPK20.89477860
67MOS0.86719185
68CSNK1G30.85081221
69DAPK10.84047687
70CDK90.82918108
71CSNK1A1L0.81277126
72MAP2K30.80508546
73LMTK20.79228428
74ABL20.79225277
75MAP3K10.78252253
76PDK20.76785123
77EPHB20.76733030
78MAP3K70.76117577
79MAP3K100.75908710
80EPHB10.74558696
81PDGFRA0.74183663
82MAP2K10.72825747
83PAK40.72701805
84BRAF0.72513582
85MAP3K130.71491104
86FGFR40.71233940
87NTRK20.70966053
88GRK70.68836096
89PDK10.67759575
90BMX0.67742613
91MINK10.67555871
92MTOR0.67271244
93MARK20.67206617
94MAP2K20.64289748
95AKT20.64001120
96EPHA20.62688115
97GRK60.62196628
98CDK70.61687170
99PAK20.61194724
100PAK10.61102067
101PTK20.59847300
102MAP3K80.59457117
103MAPK110.58295284
104KIT0.57556728
105DAPK30.57548700
106DDR20.56715780
107MAPKAPK50.54228139
108PASK0.53816977
109RIPK10.53542516
110STK160.53333659
111PDPK10.53150091
112MAP4K10.52999537
113CDK150.52835035
114DYRK1B0.52750784
115PAK30.52165079
116MARK10.51617308
117CDK11A0.50392880
118MAP3K20.50274557
119STK100.48625353
120NEK90.47634187
121ZAP700.47335939
122RPS6KA20.46902966
123PRKCH0.46635852
124PRKCG0.45882799
125CSK0.45410217
126CDK180.43742119
127PRKG20.43075934
128TGFBR20.41877817
129BRSK10.41377638
130CDK50.40651175
131CAMKK20.40420182
132FES0.39415118
133DYRK30.37471990
134PRKAA10.37048237
135ILK0.36871547
136TAOK30.36470700
137ERBB40.35808662
138CDK140.35760366
139TESK20.34885642
140CAMK10.34791481
141BCR0.31285843
142MAPKAPK20.31051936
143RPS6KC10.30495127
144RPS6KL10.30495127
145TYK20.30078164
146RPS6KA40.28852336
147GRK50.27356337

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.98050022
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.13759079
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.69114057
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.61361481
5Vitamin B6 metabolism_Homo sapiens_hsa007502.59762231
6Proteasome_Homo sapiens_hsa030502.34818682
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.34184935
8Biosynthesis of amino acids_Homo sapiens_hsa012302.31455127
9Arginine biosynthesis_Homo sapiens_hsa002202.25543074
10Synaptic vesicle cycle_Homo sapiens_hsa047212.13815713
11Shigellosis_Homo sapiens_hsa051312.11970401
12Other glycan degradation_Homo sapiens_hsa005112.10564520
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05985404
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.03483620
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.92260098
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.85262834
17Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.84631327
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.77216915
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74737963
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73070210
21Fatty acid biosynthesis_Homo sapiens_hsa000611.65366482
22Carbon metabolism_Homo sapiens_hsa012001.61290755
23Salmonella infection_Homo sapiens_hsa051321.60185989
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58885508
25Spliceosome_Homo sapiens_hsa030401.55563053
26Pyruvate metabolism_Homo sapiens_hsa006201.54987302
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.54697346
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.54037860
29Fatty acid degradation_Homo sapiens_hsa000711.53894919
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50202025
31Base excision repair_Homo sapiens_hsa034101.50096860
32Apoptosis_Homo sapiens_hsa042101.44199134
33Fatty acid metabolism_Homo sapiens_hsa012121.43975581
34Bile secretion_Homo sapiens_hsa049761.42302649
35Selenocompound metabolism_Homo sapiens_hsa004501.40347714
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40117331
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33111366
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32911931
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.31513520
40Pentose phosphate pathway_Homo sapiens_hsa000301.30600080
41Chronic myeloid leukemia_Homo sapiens_hsa052201.28388814
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26356984
43Caffeine metabolism_Homo sapiens_hsa002321.25798398
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25286559
45p53 signaling pathway_Homo sapiens_hsa041151.21880401
46Glucagon signaling pathway_Homo sapiens_hsa049221.19268303
47Fat digestion and absorption_Homo sapiens_hsa049751.17766105
48Glycerolipid metabolism_Homo sapiens_hsa005611.17681708
49DNA replication_Homo sapiens_hsa030301.16437323
50Fructose and mannose metabolism_Homo sapiens_hsa000511.15454046
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13967158
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13103055
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12888874
54mTOR signaling pathway_Homo sapiens_hsa041501.12422049
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10570736
56Pyrimidine metabolism_Homo sapiens_hsa002401.10349399
57Insulin secretion_Homo sapiens_hsa049111.09556679
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06804954
59PPAR signaling pathway_Homo sapiens_hsa033201.06751280
60Notch signaling pathway_Homo sapiens_hsa043301.06715350
61Pancreatic cancer_Homo sapiens_hsa052121.06254823
62Propanoate metabolism_Homo sapiens_hsa006401.06138259
63Adipocytokine signaling pathway_Homo sapiens_hsa049201.00974775
64Acute myeloid leukemia_Homo sapiens_hsa052211.00733177
65Fatty acid elongation_Homo sapiens_hsa000620.99763218
66Epstein-Barr virus infection_Homo sapiens_hsa051690.98687837
67Pancreatic secretion_Homo sapiens_hsa049720.97848826
68Viral carcinogenesis_Homo sapiens_hsa052030.97835332
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.96624155
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96062669
71Cocaine addiction_Homo sapiens_hsa050300.92915300
72Long-term potentiation_Homo sapiens_hsa047200.92721922
73Sulfur relay system_Homo sapiens_hsa041220.92378577
74Estrogen signaling pathway_Homo sapiens_hsa049150.90187727
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89615465
76GABAergic synapse_Homo sapiens_hsa047270.88829163
77Hepatitis B_Homo sapiens_hsa051610.88542554
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88108973
79Insulin signaling pathway_Homo sapiens_hsa049100.86710811
80Amphetamine addiction_Homo sapiens_hsa050310.86494616
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86148562
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82943977
83Oocyte meiosis_Homo sapiens_hsa041140.82710650
84Ribosome_Homo sapiens_hsa030100.82405971
85Thyroid cancer_Homo sapiens_hsa052160.82348694
86Gastric acid secretion_Homo sapiens_hsa049710.79624097
87Olfactory transduction_Homo sapiens_hsa047400.78123179
88Butanoate metabolism_Homo sapiens_hsa006500.77973980
89Type II diabetes mellitus_Homo sapiens_hsa049300.77854747
90Bladder cancer_Homo sapiens_hsa052190.77451483
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77081173
92Folate biosynthesis_Homo sapiens_hsa007900.76633894
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.75262004
94Insulin resistance_Homo sapiens_hsa049310.74087226
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73765673
96Phagosome_Homo sapiens_hsa041450.73158711
97Hepatitis C_Homo sapiens_hsa051600.71204946
98Gap junction_Homo sapiens_hsa045400.71157915
99Osteoclast differentiation_Homo sapiens_hsa043800.69673172
100GnRH signaling pathway_Homo sapiens_hsa049120.69419248
101Focal adhesion_Homo sapiens_hsa045100.69342343
102Herpes simplex infection_Homo sapiens_hsa051680.68800350
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68794270
104Sulfur metabolism_Homo sapiens_hsa009200.68101529
105Galactose metabolism_Homo sapiens_hsa000520.67480600
106HTLV-I infection_Homo sapiens_hsa051660.66418988
107TNF signaling pathway_Homo sapiens_hsa046680.66301658
108Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64720020
109Proteoglycans in cancer_Homo sapiens_hsa052050.64639430
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.64406662
111VEGF signaling pathway_Homo sapiens_hsa043700.63951711
112Circadian entrainment_Homo sapiens_hsa047130.63679918
113Colorectal cancer_Homo sapiens_hsa052100.63456981
114Prion diseases_Homo sapiens_hsa050200.63372045
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62596124
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.62483890
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.62421813
118Dopaminergic synapse_Homo sapiens_hsa047280.62185092
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62113153
120Tuberculosis_Homo sapiens_hsa051520.61879175
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61382521
122Small cell lung cancer_Homo sapiens_hsa052220.61113440
123Arginine and proline metabolism_Homo sapiens_hsa003300.60896374
124Tryptophan metabolism_Homo sapiens_hsa003800.60221113
125Cell cycle_Homo sapiens_hsa041100.58647821
126Collecting duct acid secretion_Homo sapiens_hsa049660.58499586
127Nucleotide excision repair_Homo sapiens_hsa034200.58460819
128Measles_Homo sapiens_hsa051620.58384821
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.58019492
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.57805839
131Lysosome_Homo sapiens_hsa041420.57548491
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57071566
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56364973
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55615621
135Endometrial cancer_Homo sapiens_hsa052130.55539366
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55346538
137Legionellosis_Homo sapiens_hsa051340.54833647
138Toxoplasmosis_Homo sapiens_hsa051450.54570532
139Thyroid hormone synthesis_Homo sapiens_hsa049180.54483567
140Salivary secretion_Homo sapiens_hsa049700.54436668
141AMPK signaling pathway_Homo sapiens_hsa041520.53111670
142Endocytosis_Homo sapiens_hsa041440.52896151
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52509619
144Viral myocarditis_Homo sapiens_hsa054160.52491244
145Protein digestion and absorption_Homo sapiens_hsa049740.50555659
146Regulation of autophagy_Homo sapiens_hsa041400.49426279
147Vibrio cholerae infection_Homo sapiens_hsa051100.49022123
148Oxytocin signaling pathway_Homo sapiens_hsa049210.48980861
149Glioma_Homo sapiens_hsa052140.48711418
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47815169
151Influenza A_Homo sapiens_hsa051640.47415098
152Pertussis_Homo sapiens_hsa051330.47408971
153Leukocyte transendothelial migration_Homo sapiens_hsa046700.47375248
154RNA polymerase_Homo sapiens_hsa030200.46917338
155Steroid biosynthesis_Homo sapiens_hsa001000.46500182
156RNA transport_Homo sapiens_hsa030130.44302124
157AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43710494
158Drug metabolism - other enzymes_Homo sapiens_hsa009830.43033986
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42536957
160Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42091777
161Glutathione metabolism_Homo sapiens_hsa004800.41857549
162Lysine degradation_Homo sapiens_hsa003100.41697771
163Non-small cell lung cancer_Homo sapiens_hsa052230.37995195
164Renin secretion_Homo sapiens_hsa049240.37080112
165Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36235610
166beta-Alanine metabolism_Homo sapiens_hsa004100.35919882
167Glutamatergic synapse_Homo sapiens_hsa047240.35042088
168N-Glycan biosynthesis_Homo sapiens_hsa005100.34661924

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