RNF26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this intronless gene contains a C3HC5 type of RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. The expression of this gene was found to be upregulated in cancer cell lines derived from different types of cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.61133024
2DNA unwinding involved in DNA replication (GO:0006268)5.61118916
3protein localization to chromosome, centromeric region (GO:0071459)5.25176791
4establishment of integrated proviral latency (GO:0075713)4.95632829
5mitotic sister chromatid segregation (GO:0000070)4.78906018
6DNA strand elongation involved in DNA replication (GO:0006271)4.78656428
7mitotic chromosome condensation (GO:0007076)4.62488899
8DNA strand elongation (GO:0022616)4.51684014
9sister chromatid segregation (GO:0000819)4.48372963
10COPI coating of Golgi vesicle (GO:0048205)4.47044036
11Golgi transport vesicle coating (GO:0048200)4.47044036
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.40256737
13mitotic nuclear envelope disassembly (GO:0007077)4.35302479
14mitotic metaphase plate congression (GO:0007080)4.33174225
15positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.20675575
16positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.20675575
17positive regulation of mitotic sister chromatid separation (GO:1901970)4.20675575
18DNA replication initiation (GO:0006270)4.14875311
19telomere maintenance via semi-conservative replication (GO:0032201)4.08671037
20nuclear envelope disassembly (GO:0051081)4.06697084
21membrane disassembly (GO:0030397)4.06697084
22establishment of viral latency (GO:0019043)3.99305533
23regulation of spindle organization (GO:0090224)3.95894844
24kinetochore organization (GO:0051383)3.93124306
25folic acid-containing compound biosynthetic process (GO:0009396)3.81904113
26attachment of spindle microtubules to kinetochore (GO:0008608)3.81637662
27metaphase plate congression (GO:0051310)3.78095212
28establishment of chromosome localization (GO:0051303)3.76651406
29negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.73945591
30L-serine metabolic process (GO:0006563)3.69824436
31regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.67883564
32protein maturation by protein folding (GO:0022417)3.66358943
33protein localization to chromosome (GO:0034502)3.66082298
34maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.62048883
35regulation of mammary gland epithelial cell proliferation (GO:0033599)3.60519235
36kinetochore assembly (GO:0051382)3.60342525
37regulation of mitotic spindle organization (GO:0060236)3.55755408
38DNA ligation (GO:0006266)3.55210168
39heterochromatin organization (GO:0070828)3.54358878
40protein retention in ER lumen (GO:0006621)3.54009804
41negative regulation of RNA splicing (GO:0033119)3.53069342
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.51102434
43DNA duplex unwinding (GO:0032508)3.48634316
44DNA replication checkpoint (GO:0000076)3.44547378
45formation of translation preinitiation complex (GO:0001731)3.44520098
46telomere maintenance via recombination (GO:0000722)3.44282255
47DNA geometric change (GO:0032392)3.44089989
48regulation of chromosome segregation (GO:0051983)3.40478503
49DNA replication-dependent nucleosome assembly (GO:0006335)3.39353114
50DNA replication-dependent nucleosome organization (GO:0034723)3.39353114
51mitotic recombination (GO:0006312)3.38606838
52negative regulation of chromosome segregation (GO:0051985)3.35777898
53chromosome condensation (GO:0030261)3.35409502
54proline biosynthetic process (GO:0006561)3.33870859
55proteasome assembly (GO:0043248)3.33379492
56nuclear envelope reassembly (GO:0031468)3.31834713
57mitotic nuclear envelope reassembly (GO:0007084)3.31834713
58spindle assembly checkpoint (GO:0071173)3.31542522
59DNA replication-independent nucleosome organization (GO:0034724)3.31134211
60DNA replication-independent nucleosome assembly (GO:0006336)3.31134211
61CENP-A containing nucleosome assembly (GO:0034080)3.29865871
62spindle checkpoint (GO:0031577)3.29728491
63mitotic spindle assembly checkpoint (GO:0007094)3.29306051
64positive regulation of chromosome segregation (GO:0051984)3.28300198
65anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28029776
66nuclear envelope organization (GO:0006998)3.27559792
67negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.26184352
68negative regulation of sister chromatid segregation (GO:0033046)3.26184352
69negative regulation of mitotic sister chromatid separation (GO:2000816)3.26184352
70negative regulation of mitotic sister chromatid segregation (GO:0033048)3.26184352
71chromatin assembly or disassembly (GO:0006333)3.25976324
72telomere maintenance via telomere lengthening (GO:0010833)3.25284115
73chromatin remodeling at centromere (GO:0031055)3.24926398
74chromosome segregation (GO:0007059)3.24080039
75viral transcription (GO:0019083)3.21847850
76negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.21397060
77nuclear pore organization (GO:0006999)3.16880929
78regulation of translational fidelity (GO:0006450)3.16271824
79translational termination (GO:0006415)3.14101098
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13773559
81negative regulation of mRNA processing (GO:0050686)3.12801689
82nucleotide-excision repair, DNA gap filling (GO:0006297)3.12495741
83DNA deamination (GO:0045006)3.10672470
84regulation of sister chromatid cohesion (GO:0007063)3.10526375
85DNA conformation change (GO:0071103)3.10222219
86translesion synthesis (GO:0019985)3.08409794
87mitotic spindle checkpoint (GO:0071174)3.08258479
88histone arginine methylation (GO:0034969)3.06940522
89ribosomal small subunit assembly (GO:0000028)3.06692729
90regulation of mitotic metaphase/anaphase transition (GO:0030071)3.04440530
91negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04064682
92histone-serine phosphorylation (GO:0035404)3.03387300
93peptidyl-arginine omega-N-methylation (GO:0035247)3.01486103
94translational elongation (GO:0006414)3.01463874
95regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01235436
96nucleobase-containing small molecule interconversion (GO:0015949)3.01021628
97nuclear pore complex assembly (GO:0051292)3.00949930
98spliceosomal tri-snRNP complex assembly (GO:0000244)3.00566329
993-UTR-mediated mRNA stabilization (GO:0070935)2.99556760
100cellular protein complex localization (GO:0034629)2.96483066
101regulation of translational termination (GO:0006449)2.95267946
102glucocorticoid receptor signaling pathway (GO:0042921)2.92675379
103base-excision repair (GO:0006284)2.92288218
104negative regulation of mRNA metabolic process (GO:1903312)2.92174417
105nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.90817009
106meiotic chromosome segregation (GO:0045132)2.89939586
107translational initiation (GO:0006413)2.88225589
108positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87936662
109IMP biosynthetic process (GO:0006188)2.87601068
110DNA topological change (GO:0006265)2.87562502
111regulation of sister chromatid segregation (GO:0033045)2.87388636
112regulation of mitotic sister chromatid separation (GO:0010965)2.87388636
113regulation of mitotic sister chromatid segregation (GO:0033047)2.87388636
114DNA packaging (GO:0006323)2.86908011
115ATP-dependent chromatin remodeling (GO:0043044)2.86530449
116negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85747210
117negative regulation of ligase activity (GO:0051352)2.85747210
118mitotic sister chromatid cohesion (GO:0007064)2.84487156
119histone exchange (GO:0043486)2.84137417
120regulation of exit from mitosis (GO:0007096)2.82005446
121protein complex localization (GO:0031503)2.79692901
122ventricular cardiac muscle cell development (GO:0055015)2.79288603
123maturation of SSU-rRNA (GO:0030490)2.75739887
124pre-miRNA processing (GO:0031054)2.74028364
125chromatin assembly (GO:0031497)2.73586015
126regulation of chromatin binding (GO:0035561)2.73063777
127mitotic G1 DNA damage checkpoint (GO:0031571)2.71754333
128RNA stabilization (GO:0043489)2.71262320
129ribosome assembly (GO:0042255)2.70977475
130double-strand break repair via nonhomologous end joining (GO:0006303)2.69910218
131non-recombinational repair (GO:0000726)2.69910218
132establishment of mitotic spindle localization (GO:0040001)2.67696494
133peptidyl-lysine dimethylation (GO:0018027)2.64246241
134planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63417258
135deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.63134514
136mitotic cytokinesis (GO:0000281)2.62933469
137peptidyl-arginine N-methylation (GO:0035246)2.61242500
138peptidyl-arginine methylation (GO:0018216)2.61242500
139regulation of ubiquitin-protein transferase activity (GO:0051438)2.60374895
140negative regulation of mitosis (GO:0045839)2.58490643
141positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.57955553
142pentose-phosphate shunt (GO:0006098)2.56486248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.40773677
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.15316952
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92890687
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.54609650
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.49688945
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47634101
7MYC_22102868_ChIP-Seq_BL_Human2.95357981
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.71633328
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44991562
10AR_21909140_ChIP-Seq_LNCAP_Human2.36151429
11VDR_21846776_ChIP-Seq_THP-1_Human2.26253773
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26091175
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22241557
14XRN2_22483619_ChIP-Seq_HELA_Human2.16728772
15ZNF263_19887448_ChIP-Seq_K562_Human2.07973989
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07866963
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.01532626
18CIITA_25753668_ChIP-Seq_RAJI_Human1.92078175
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.87147724
20NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84447079
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82155955
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78439776
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.78101319
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68798535
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66675693
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63886986
27CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.61327681
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59989382
29* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56754105
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55887884
31ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53869165
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53701374
33* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52740345
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50986865
35GABP_19822575_ChIP-Seq_HepG2_Human1.50916763
36FOXP3_21729870_ChIP-Seq_TREG_Human1.50871170
37* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50729798
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46715785
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46439543
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45850304
41KDM5A_27292631_Chip-Seq_BREAST_Human1.44004537
42TTF2_22483619_ChIP-Seq_HELA_Human1.42834488
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40640681
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38862580
45DCP1A_22483619_ChIP-Seq_HELA_Human1.38720838
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38144040
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37345078
48VDR_23849224_ChIP-Seq_CD4+_Human1.36670033
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36483466
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.34812736
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33240881
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33184140
53* ELK3_25401928_ChIP-Seq_HUVEC_Human1.32938114
54TCF7_22412390_ChIP-Seq_EML_Mouse1.32635809
55* RACK7_27058665_Chip-Seq_MCF-7_Human1.31983316
56* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28188229
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26513311
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25190332
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24664002
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23994174
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23516723
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.20243618
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19402267
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18595767
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18447787
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.17242348
67UTX_26944678_Chip-Seq_JUKART_Human1.15754238
68TFEB_21752829_ChIP-Seq_HELA_Human1.15289482
69KDM2B_26808549_Chip-Seq_DND41_Human1.14974423
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14435326
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13870516
72CLOCK_20551151_ChIP-Seq_293T_Human1.12528760
73MAF_26560356_Chip-Seq_TH1_Human1.12458703
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12146450
75SCL_19346495_ChIP-Seq_HPC-7_Human1.09118621
76CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08454452
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08194765
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.08036955
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07309681
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07259869
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06669309
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06413892
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05812190
84VDR_24763502_ChIP-Seq_THP-1_Human1.04467891
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04033476
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03777296
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03005721
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02695170
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02517766
90ATF3_27146783_Chip-Seq_COLON_Human1.01222096
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00977012
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00772099
93TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.00740289
94NANOG_21062744_ChIP-ChIP_HESCs_Human0.99261258
95GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99000183
96OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98900506
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98586860
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98572273
99ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98548857
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97546411
101* FOXP1_21924763_ChIP-Seq_HESCs_Human0.97492830
102HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96703202
103TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96677525
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96461073
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94976188
106SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94896183
107* LXR_22292898_ChIP-Seq_THP-1_Human0.94642884
108YY1_21170310_ChIP-Seq_MESCs_Mouse0.94050025
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93835427
110* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93307739
111CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93290107
112SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93206692
113BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93065357
114MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92846580
115TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92386651
116* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92331897
117MAF_26560356_Chip-Seq_TH2_Human0.91509707
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91085374
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90947959
120NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90208229
121RUNX1_22412390_ChIP-Seq_EML_Mouse0.89563151
122SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88958145
123ELF1_20517297_ChIP-Seq_JURKAT_Human0.88525318
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87647290
125SPI1_23547873_ChIP-Seq_NB4_Human0.87569128
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87403833
127MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.85853478
128SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85718432
129FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85524663
130KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85275101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology4.44090831
2MP0003693_abnormal_embryo_hatching4.34447424
3MP0010094_abnormal_chromosome_stability3.79907339
4MP0003077_abnormal_cell_cycle3.71035465
5MP0004957_abnormal_blastocyst_morpholog3.64995719
6MP0010030_abnormal_orbit_morphology2.74881870
7MP0003705_abnormal_hypodermis_morpholog2.72226215
8MP0008007_abnormal_cellular_replicative2.57315483
9MP0003123_paternal_imprinting2.49049952
10MP0002396_abnormal_hematopoietic_system2.48099013
11MP0010352_gastrointestinal_tract_polyps2.32138906
12MP0008057_abnormal_DNA_replication2.30843996
13MP0001730_embryonic_growth_arrest2.29232745
14MP0000350_abnormal_cell_proliferation2.28638690
15MP0010307_abnormal_tumor_latency2.26751130
16MP0006054_spinal_hemorrhage2.23232273
17MP0004272_abnormal_basement_membrane2.19286730
18MP0008932_abnormal_embryonic_tissue2.08436258
19MP0000490_abnormal_crypts_of1.95458990
20MP0004808_abnormal_hematopoietic_stem1.95401415
21MP0005076_abnormal_cell_differentiation1.84298761
22MP0001697_abnormal_embryo_size1.83777854
23MP0009278_abnormal_bone_marrow1.72780648
24MP0001672_abnormal_embryogenesis/_devel1.71400785
25MP0005380_embryogenesis_phenotype1.71400785
26MP0005397_hematopoietic_system_phenotyp1.70153900
27MP0001545_abnormal_hematopoietic_system1.70153900
28MP0008058_abnormal_DNA_repair1.67904550
29MP0002080_prenatal_lethality1.64737157
30MP0003984_embryonic_growth_retardation1.61697386
31MP0002085_abnormal_embryonic_tissue1.60243027
32MP0004197_abnormal_fetal_growth/weight/1.59123530
33MP0005501_abnormal_skin_physiology1.57781449
34MP0002088_abnormal_embryonic_growth/wei1.57737760
35MP0003718_maternal_effect1.54387295
36MP0002084_abnormal_developmental_patter1.52842857
37MP0002086_abnormal_extraembryonic_tissu1.52763887
38MP0002019_abnormal_tumor_incidence1.50974711
39MP0009053_abnormal_anal_canal1.50005614
40MP0002877_abnormal_melanocyte_morpholog1.45285555
41MP0002089_abnormal_postnatal_growth/wei1.42810112
42MP0008260_abnormal_autophagy1.42776441
43MP0000566_synostosis1.42216673
44MP0008877_abnormal_DNA_methylation1.39990551
45MP0000534_abnormal_ureter_morphology1.39037944
46MP0009333_abnormal_splenocyte_physiolog1.35894326
47MP0000313_abnormal_cell_death1.35552524
48MP0002796_impaired_skin_barrier1.32295369
49MP0005451_abnormal_body_composition1.31660784
50MP0005623_abnormal_meninges_morphology1.29651486
51MP0000703_abnormal_thymus_morphology1.26675004
52MP0003115_abnormal_respiratory_system1.25893502
53MP0001849_ear_inflammation1.23751699
54MP0003121_genomic_imprinting1.22693264
55MP0003937_abnormal_limbs/digits/tail_de1.22181149
56MP0002254_reproductive_system_inflammat1.21151429
57MP0000428_abnormal_craniofacial_morphol1.19327376
58MP0001915_intracranial_hemorrhage1.18905678
59MP0000358_abnormal_cell_content/1.17182559
60MP0005023_abnormal_wound_healing1.16867846
61MP0001727_abnormal_embryo_implantation1.16276626
62MP0002398_abnormal_bone_marrow1.15790357
63MP0002697_abnormal_eye_size1.14928445
64MP0003566_abnormal_cell_adhesion1.13463633
65MP0002102_abnormal_ear_morphology1.11478497
66MP0010234_abnormal_vibrissa_follicle1.10870319
67MP0003941_abnormal_skin_development1.10509249
68MP0003385_abnormal_body_wall1.09769132
69MP0003786_premature_aging1.09597013
70MP0003567_abnormal_fetal_cardiomyocyte1.08686671
71MP0003283_abnormal_digestive_organ1.08592614
72MP0002722_abnormal_immune_system1.08109735
73MP0000537_abnormal_urethra_morphology1.08044268
74MP0008438_abnormal_cutaneous_collagen1.07637328
75MP0005257_abnormal_intraocular_pressure1.07189987
76MP0003119_abnormal_digestive_system1.06487951
77MP0003656_abnormal_erythrocyte_physiolo1.05726043
78MP0004858_abnormal_nervous_system1.03830801
79MP0001346_abnormal_lacrimal_gland1.03639290
80MP0009672_abnormal_birth_weight1.03294230
81MP0000467_abnormal_esophagus_morphology1.01336993
82MP0000678_abnormal_parathyroid_gland1.01192199
83MP0000858_altered_metastatic_potential1.00778427
84MP0003763_abnormal_thymus_physiology0.99328715
85MP0003300_gastrointestinal_ulcer0.98878404
86MP0001661_extended_life_span0.97231899
87MP0001293_anophthalmia0.97219869
88MP0000689_abnormal_spleen_morphology0.95569461
89MP0000733_abnormal_muscle_development0.92450541
90MP0000685_abnormal_immune_system0.92156916
91MP0003303_peritoneal_inflammation0.92142687
92MP0002092_abnormal_eye_morphology0.90687092
93MP0002282_abnormal_trachea_morphology0.90644208
94MP0002932_abnormal_joint_morphology0.88038180
95MP0001286_abnormal_eye_development0.87296072
96MP0005394_taste/olfaction_phenotype0.87114977
97MP0005499_abnormal_olfactory_system0.87114977
98MP0005058_abnormal_lysosome_morphology0.86584806
99MP0000762_abnormal_tongue_morphology0.86469818
100MP0005083_abnormal_biliary_tract0.86096488
101MP0002249_abnormal_larynx_morphology0.85970151
102MP0002111_abnormal_tail_morphology0.84951030
103MP0002429_abnormal_blood_cell0.84893719
104MP0003453_abnormal_keratinocyte_physiol0.84867875
105MP0002210_abnormal_sex_determination0.84272341
106MP0000751_myopathy0.83494739
107MP0000477_abnormal_intestine_morphology0.83117048
108MP0000432_abnormal_head_morphology0.82611068
109MP0001145_abnormal_male_reproductive0.82282665
110MP0000462_abnormal_digestive_system0.82184627
111MP0002060_abnormal_skin_morphology0.81423056
112MP0005621_abnormal_cell_physiology0.81296758
113MP0009697_abnormal_copulation0.80152660
114MP0000049_abnormal_middle_ear0.79786622
115MP0001881_abnormal_mammary_gland0.79349515
116MP0004233_abnormal_muscle_weight0.79157914
117MP0002653_abnormal_ependyma_morphology0.78747662
118MP0001299_abnormal_eye_distance/0.78403129
119MP0008789_abnormal_olfactory_epithelium0.77873892
120MP0003279_aneurysm0.77523476
121MP0006035_abnormal_mitochondrial_morpho0.76705971
122MP0003136_yellow_coat_color0.76269856
123MP0001529_abnormal_vocalization0.76177598
124MP0004264_abnormal_extraembryonic_tissu0.75217186
125MP0002925_abnormal_cardiovascular_devel0.74229232
126MP0005384_cellular_phenotype0.73353737
127MP0000465_gastrointestinal_hemorrhage0.72855847
128MP0003186_abnormal_redox_activity0.71909836
129MP0001929_abnormal_gametogenesis0.70061599
130MP0003315_abnormal_perineum_morphology0.69697045
131MP0000653_abnormal_sex_gland0.68732765
132MP0009703_decreased_birth_body0.68480530
133MP0004185_abnormal_adipocyte_glucose0.67733719
134MP0009840_abnormal_foam_cell0.67241083
135MP0001119_abnormal_female_reproductive0.67166217
136MP0008770_decreased_survivor_rate0.66351979
137MP0003935_abnormal_craniofacial_develop0.65979570
138MP0000716_abnormal_immune_system0.65296994
139MP0005508_abnormal_skeleton_morphology0.64200524
140MP0003942_abnormal_urinary_system0.63469614
141MP0000003_abnormal_adipose_tissue0.62844949

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.72636163
2Abnormal gallbladder physiology (HP:0012438)3.59082024
3Cholecystitis (HP:0001082)3.59082024
4Progressive muscle weakness (HP:0003323)3.34182536
5Increased nuchal translucency (HP:0010880)3.31196294
6Reticulocytopenia (HP:0001896)3.29258605
7Abnormality of cells of the erythroid lineage (HP:0012130)3.12531432
8Abnormal number of erythroid precursors (HP:0012131)3.11124506
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.10104461
10Short 4th metacarpal (HP:0010044)3.10104461
11Selective tooth agenesis (HP:0001592)3.08507299
12Gout (HP:0001997)2.88874188
13Broad distal phalanx of finger (HP:0009836)2.78813446
14Aplasia/Hypoplasia of the sacrum (HP:0008517)2.78518767
15Renal duplication (HP:0000075)2.61657681
16Ankle contracture (HP:0006466)2.60526580
17Poikiloderma (HP:0001029)2.59754820
18Degeneration of anterior horn cells (HP:0002398)2.54397124
19Abnormality of the anterior horn cell (HP:0006802)2.54397124
20Hyperacusis (HP:0010780)2.54254879
21Proximal placement of thumb (HP:0009623)2.51304238
22Genu recurvatum (HP:0002816)2.49602740
23Abnormality of the umbilical cord (HP:0010881)2.48296662
24Hypoplastic pelvis (HP:0008839)2.47243484
25Deviation of the thumb (HP:0009603)2.47011796
26Patellar aplasia (HP:0006443)2.41138998
27Basal cell carcinoma (HP:0002671)2.40522395
28Thrombocytosis (HP:0001894)2.37889591
29Birth length less than 3rd percentile (HP:0003561)2.33868672
30Vertebral compression fractures (HP:0002953)2.31989189
31Long palpebral fissure (HP:0000637)2.31907791
32Small epiphyses (HP:0010585)2.31098256
33Abnormality of glycolysis (HP:0004366)2.30506843
34Carpal bone hypoplasia (HP:0001498)2.30160420
35Broad palm (HP:0001169)2.28985327
36Abnormal lung lobation (HP:0002101)2.28176530
37Medulloblastoma (HP:0002885)2.27675873
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.27258095
39Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.25868191
40Absent epiphyses (HP:0010577)2.25868191
41Abnormality of the 4th metacarpal (HP:0010012)2.25418671
42Rough bone trabeculation (HP:0100670)2.25184312
43Aplasia/Hypoplasia of the patella (HP:0006498)2.25062942
44Generalized amyotrophy (HP:0003700)2.24886847
45High pitched voice (HP:0001620)2.23143548
46Abnormality of the fingertips (HP:0001211)2.22436531
47Abnormality of the fetal cardiovascular system (HP:0010948)2.22085504
48Abnormal umbilical cord blood vessels (HP:0011403)2.22085504
49Single umbilical artery (HP:0001195)2.22085504
50Slender long bone (HP:0003100)2.21652490
51Abnormality of dentin (HP:0010299)2.20518879
52Cortical dysplasia (HP:0002539)2.20420620
53Chromsome breakage (HP:0040012)2.19108806
54Abnormality of reticulocytes (HP:0004312)2.18986205
55Achilles tendon contracture (HP:0001771)2.18738473
56Shallow orbits (HP:0000586)2.18734752
57Neonatal short-limb short stature (HP:0008921)2.18280256
58Flattened epiphyses (HP:0003071)2.18044006
59Abnormality of DNA repair (HP:0003254)2.16767362
60Facial hemangioma (HP:0000329)2.13445699
61Aplastic anemia (HP:0001915)2.13262002
62Abnormal number of incisors (HP:0011064)2.11475140
63Nonimmune hydrops fetalis (HP:0001790)2.10192026
64High anterior hairline (HP:0009890)2.08650816
65Atresia of the external auditory canal (HP:0000413)2.07838027
66Short nail (HP:0001799)2.06238711
67Ureteral duplication (HP:0000073)2.05591317
68Entropion (HP:0000621)2.05184812
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04933833
70Meckel diverticulum (HP:0002245)2.04017428
71Reticulocytosis (HP:0001923)2.02814120
72Reduced antithrombin III activity (HP:0001976)2.02354063
73Insomnia (HP:0100785)2.00447358
74Hallux valgus (HP:0001822)2.00440498
75Myelodysplasia (HP:0002863)2.00326066
76Short 5th finger (HP:0009237)1.99065170
77Ependymoma (HP:0002888)1.98618544
78Trismus (HP:0000211)1.96902557
79Oral leukoplakia (HP:0002745)1.96729691
80Microvesicular hepatic steatosis (HP:0001414)1.96518940
81Deviation of the hallux (HP:0010051)1.95802388
82Abnormality of the ileum (HP:0001549)1.95420418
83Small intestinal stenosis (HP:0012848)1.93979609
84Duodenal stenosis (HP:0100867)1.93979609
85Abnormality of the Achilles tendon (HP:0005109)1.93353708
86Colon cancer (HP:0003003)1.92513331
87Breech presentation (HP:0001623)1.92280987
88Breast hypoplasia (HP:0003187)1.92223617
89Pallor (HP:0000980)1.91679891
90Increased density of long bones (HP:0006392)1.91676326
91Spinal rigidity (HP:0003306)1.91079380
92Abnormality of the distal phalanges of the toes (HP:0010182)1.91076345
93Unilateral renal agenesis (HP:0000122)1.90023929
94Absent thumb (HP:0009777)1.89225526
95Increased serum pyruvate (HP:0003542)1.89189156
96Nephroblastoma (Wilms tumor) (HP:0002667)1.88543456
97Absent radius (HP:0003974)1.87841833
98Cafe-au-lait spot (HP:0000957)1.85782617
99Heterotopia (HP:0002282)1.85396759
100Atrophy/Degeneration involving motor neurons (HP:0007373)1.85163344
101Long eyelashes (HP:0000527)1.85094424
102Secondary amenorrhea (HP:0000869)1.84411364
103Abnormality of the calcaneus (HP:0008364)1.83597164
104Bicuspid aortic valve (HP:0001647)1.83372499
105Overlapping toe (HP:0001845)1.82761706
106Broad thumb (HP:0011304)1.82290843
107Flared metaphyses (HP:0003015)1.82023625
108Microretrognathia (HP:0000308)1.81932396
109Abnormality of chromosome stability (HP:0003220)1.81856945
110Rhabdomyosarcoma (HP:0002859)1.81830788
111Facial cleft (HP:0002006)1.80808975
112Bowel diverticulosis (HP:0005222)1.80560128
113Overriding aorta (HP:0002623)1.79976658
114Skin tags (HP:0010609)1.79778564
115Squamous cell carcinoma (HP:0002860)1.79588314
116Embryonal renal neoplasm (HP:0011794)1.78272818
117Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.77239330
118Multiple enchondromatosis (HP:0005701)1.76362134
119Prominent nose (HP:0000448)1.76274865
120Disproportionate tall stature (HP:0001519)1.75846034
121Type I transferrin isoform profile (HP:0003642)1.75643381
122Renovascular hypertension (HP:0100817)1.75201032
123Premature skin wrinkling (HP:0100678)1.74160044
124Broad phalanges of the hand (HP:0009768)1.73929519
125Neoplasm of striated muscle (HP:0009728)1.73807616
126Abnormality of carpal bone ossification (HP:0006257)1.73526560
127Absent forearm bone (HP:0003953)1.73470731
128Aplasia involving forearm bones (HP:0009822)1.73470731
129Biconcave vertebral bodies (HP:0004586)1.73239424
130Bladder diverticulum (HP:0000015)1.72971839
131Premature rupture of membranes (HP:0001788)1.71664891
132Long foot (HP:0001833)1.71593766
133Preauricular skin tag (HP:0000384)1.70148807
134Abnormality of the carotid arteries (HP:0005344)1.70066948
135Ulnar bowing (HP:0003031)1.69506684
136Gastrointestinal carcinoma (HP:0002672)1.69444792
137Malignant gastrointestinal tract tumors (HP:0006749)1.69444792
138Neoplasm of the pancreas (HP:0002894)1.69356025
139Abnormality of the peritoneum (HP:0002585)1.69271698
140Ectopic kidney (HP:0000086)1.67506190
141Shoulder girdle muscle weakness (HP:0003547)1.67398396
142Abnormality of the heme biosynthetic pathway (HP:0010472)1.67013475
143Cerebral aneurysm (HP:0004944)1.66612286
144Broad toe (HP:0001837)1.66293370
145Reduced subcutaneous adipose tissue (HP:0003758)1.66157311
146Upper limb amyotrophy (HP:0009129)1.65388628
147Distal upper limb amyotrophy (HP:0007149)1.65388628
148Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64581032
149Aplasia/Hypoplasia of the uvula (HP:0010293)1.64299500
150Cutis marmorata (HP:0000965)1.64115860
151Diastasis recti (HP:0001540)1.63757300
152Broad hallux (HP:0010055)1.63683079
153Duplication of thumb phalanx (HP:0009942)1.62143867
154Urethral obstruction (HP:0000796)1.61999582
155Horseshoe kidney (HP:0000085)1.61655445
156Abnormal trabecular bone morphology (HP:0100671)1.58317872
157Cholelithiasis (HP:0001081)1.58255129
158Duplicated collecting system (HP:0000081)1.57926929
159Abnormal ventriculo-arterial connection (HP:0011563)1.57790940
160Transposition of the great arteries (HP:0001669)1.57790940
161Abnormal connection of the cardiac segments (HP:0011545)1.57790940
162Ragged-red muscle fibers (HP:0003200)1.57734076
163Microglossia (HP:0000171)1.57710083
164Elbow flexion contracture (HP:0002987)1.56763353
165Trigonocephaly (HP:0000243)1.54506370
166Abnormal ossification of hand bones (HP:0005921)1.53358358
167Hepatoblastoma (HP:0002884)1.52233292
168Generalized hypotonia (HP:0001290)1.51543613
169Abnormality of the preputium (HP:0100587)1.50249607
170Midface retrusion (HP:0011800)1.49962218
171Back pain (HP:0003418)1.49879680
172Abnormalities of placenta or umbilical cord (HP:0001194)1.49678744
173Upper limb muscle weakness (HP:0003484)1.47748969

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.60838000
2CDC73.87415241
3EEF2K3.72040674
4VRK23.37680397
5NEK23.36831265
6TRIB33.21914358
7MAP3K103.01560236
8PKN22.75681703
9WEE12.63591914
10MKNK22.60961553
11SMG12.60582249
12CDK122.48266500
13TAOK22.41475900
14EPHA22.22646871
15TTK1.95828358
16LMTK21.93554775
17TESK21.89040832
18NEK11.80060216
19SCYL21.78183145
20PBK1.74700932
21CDK41.74544729
22STK101.67587613
23MAP3K81.61882009
24CDK71.52695232
25PAK41.52576825
26LATS21.48034053
27PLK11.47924678
28BRSK11.45516516
29TAOK11.45419585
30RPS6KA41.44353295
31BRSK21.43987607
32CDK81.41609216
33ERN11.39272015
34SIK11.37533977
35ACVR1B1.36079854
36MAP4K11.34615279
37AURKB1.34053971
38EIF2AK11.30638433
39LRRK21.30456543
40RPS6KB21.28423311
41DYRK31.27644830
42IRAK31.26302473
43LATS11.22617163
44ATR1.20277548
45MAP3K31.18458111
46CHEK21.16566456
47CDK61.02667739
48CHEK11.02456392
49GRK61.01925016
50PASK1.00638247
51AURKA0.98809770
52PTK20.98284730
53LIMK10.97307906
54TGFBR10.93123370
55ARAF0.92934320
56STK30.92475168
57STK40.91479801
58MELK0.91011984
59PRPF4B0.90778583
60NME20.90286366
61MST1R0.88492558
62ILK0.86378717
63TAF10.85457424
64FLT30.85378911
65NME10.83583540
66MAP3K110.82149317
67MAP2K30.79879710
68ABL20.77512820
69MTOR0.75522597
70ICK0.74757246
71CDK90.73047783
72PAK10.72902419
73CDK20.72593797
74PTK60.72451388
75TESK10.72116469
76TRIM280.71971102
77ALK0.71508002
78KDR0.71392660
79BRD40.71306159
80ERBB40.70419015
81PAK20.67161229
82MKNK10.65434245
83CLK10.64883722
84FGFR10.64102016
85DAPK10.64009206
86TLK10.63804377
87MAP3K60.63686588
88MAPK110.62760474
89MAPKAPK30.62369917
90STK160.61348437
91CCNB10.58274744
92ATM0.57043036
93PIM10.56519475
94PLK40.55160962
95PLK30.54367854
96TSSK60.52323065
97BMX0.52229500
98VRK10.51855023
99BTK0.51511046
100ZAP700.51034368
101AKT20.50965644
102BRAF0.48669437
103EIF2AK20.48581167
104CDK10.47899066
105PDGFRA0.47541211
106FGFR40.47497201
107MET0.47383584
108PRKD30.45391846
109RAF10.45037136
110SRPK10.44626425
111TTN0.42810914
112CDK11A0.40241997
113SIK30.37954694
114CDK150.37553985
115CSNK1G30.36022183
116JAK30.34954616
117EPHB10.32847220
118NTRK10.32414740
119KIT0.32229872
120CDK180.32011442
121CSNK2A10.31933452
122BCKDK0.31715753
123STK380.31377076
124UHMK10.31186794
125CSF1R0.28155323
126KSR20.27897429
127STK38L0.26240970
128CDK140.26110768
129CSNK2A20.25744773
130MAPKAPK20.25733318
131PIM20.25247392

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.23520407
2Mismatch repair_Homo sapiens_hsa034303.70890440
3Cell cycle_Homo sapiens_hsa041103.33919470
4Base excision repair_Homo sapiens_hsa034103.31879820
5Spliceosome_Homo sapiens_hsa030402.83512274
6RNA transport_Homo sapiens_hsa030132.79727058
7Nucleotide excision repair_Homo sapiens_hsa034202.64975954
8Homologous recombination_Homo sapiens_hsa034402.44669358
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33650599
10One carbon pool by folate_Homo sapiens_hsa006702.27311430
11Ribosome_Homo sapiens_hsa030102.25654288
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15600570
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.01914357
14Fatty acid elongation_Homo sapiens_hsa000621.97641336
15mRNA surveillance pathway_Homo sapiens_hsa030151.85432912
16p53 signaling pathway_Homo sapiens_hsa041151.75019293
17Fanconi anemia pathway_Homo sapiens_hsa034601.66551615
18Pyrimidine metabolism_Homo sapiens_hsa002401.64089117
19RNA polymerase_Homo sapiens_hsa030201.64042296
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59424167
21RNA degradation_Homo sapiens_hsa030181.54652906
22Galactose metabolism_Homo sapiens_hsa000521.54543730
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.53319067
24Oocyte meiosis_Homo sapiens_hsa041141.42780989
25Chronic myeloid leukemia_Homo sapiens_hsa052201.37252935
26Fructose and mannose metabolism_Homo sapiens_hsa000511.35873992
27Bladder cancer_Homo sapiens_hsa052191.32810458
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31808173
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31515897
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31473630
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.29967927
32Non-homologous end-joining_Homo sapiens_hsa034501.28519395
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27501957
34HTLV-I infection_Homo sapiens_hsa051661.27304795
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26675602
36MicroRNAs in cancer_Homo sapiens_hsa052061.26167330
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25070719
38Pyruvate metabolism_Homo sapiens_hsa006201.23136429
39Notch signaling pathway_Homo sapiens_hsa043301.22497335
40Viral carcinogenesis_Homo sapiens_hsa052031.18951520
41Thyroid cancer_Homo sapiens_hsa052161.14664222
42Small cell lung cancer_Homo sapiens_hsa052221.14456079
43Basal transcription factors_Homo sapiens_hsa030221.13901173
44Proteasome_Homo sapiens_hsa030501.12537269
45Biosynthesis of amino acids_Homo sapiens_hsa012301.08084154
46N-Glycan biosynthesis_Homo sapiens_hsa005101.04664049
47Steroid biosynthesis_Homo sapiens_hsa001001.02643194
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01874434
49Pentose phosphate pathway_Homo sapiens_hsa000301.01691698
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.01447078
51Basal cell carcinoma_Homo sapiens_hsa052170.98875022
52Glutathione metabolism_Homo sapiens_hsa004800.98827219
53Colorectal cancer_Homo sapiens_hsa052100.98453853
54Non-small cell lung cancer_Homo sapiens_hsa052230.97440438
55Selenocompound metabolism_Homo sapiens_hsa004500.96384324
56Antigen processing and presentation_Homo sapiens_hsa046120.93802427
57Pancreatic cancer_Homo sapiens_hsa052120.91972704
58Epstein-Barr virus infection_Homo sapiens_hsa051690.90324297
59Sulfur relay system_Homo sapiens_hsa041220.88106382
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83322200
61Lysine degradation_Homo sapiens_hsa003100.81777615
62Systemic lupus erythematosus_Homo sapiens_hsa053220.81506885
63Herpes simplex infection_Homo sapiens_hsa051680.81456740
64Hepatitis B_Homo sapiens_hsa051610.79812815
65Hippo signaling pathway_Homo sapiens_hsa043900.78495364
66Shigellosis_Homo sapiens_hsa051310.78484614
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78157564
68Acute myeloid leukemia_Homo sapiens_hsa052210.78094539
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.77756040
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77239396
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77156386
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76895951
73Hedgehog signaling pathway_Homo sapiens_hsa043400.76082606
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74233695
75Vibrio cholerae infection_Homo sapiens_hsa051100.73747465
76mTOR signaling pathway_Homo sapiens_hsa041500.71877479
77Apoptosis_Homo sapiens_hsa042100.70826143
78Arginine and proline metabolism_Homo sapiens_hsa003300.68662521
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68092601
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66558000
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66363430
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64435498
83Fatty acid metabolism_Homo sapiens_hsa012120.63373081
84Other glycan degradation_Homo sapiens_hsa005110.63292085
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62516882
86Proteoglycans in cancer_Homo sapiens_hsa052050.62340918
87VEGF signaling pathway_Homo sapiens_hsa043700.61640270
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.59615672
89Purine metabolism_Homo sapiens_hsa002300.58940213
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58830312
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58296712
92Phenylalanine metabolism_Homo sapiens_hsa003600.57386542
93Endometrial cancer_Homo sapiens_hsa052130.57141892
94TGF-beta signaling pathway_Homo sapiens_hsa043500.57113827
95Glioma_Homo sapiens_hsa052140.55457992
96HIF-1 signaling pathway_Homo sapiens_hsa040660.52468077
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50687124
98Huntingtons disease_Homo sapiens_hsa050160.50638489
99Pathways in cancer_Homo sapiens_hsa052000.50611188
100Folate biosynthesis_Homo sapiens_hsa007900.49283055
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48823287
102B cell receptor signaling pathway_Homo sapiens_hsa046620.48126524
103Adherens junction_Homo sapiens_hsa045200.47000924
104Carbon metabolism_Homo sapiens_hsa012000.46522998
105Prostate cancer_Homo sapiens_hsa052150.45142267
106Metabolic pathways_Homo sapiens_hsa011000.44123925
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42318654
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41757348
109Primary immunodeficiency_Homo sapiens_hsa053400.41372709
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41331712
111Focal adhesion_Homo sapiens_hsa045100.39895595
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.38841153
113Tight junction_Homo sapiens_hsa045300.38803375
114Arginine biosynthesis_Homo sapiens_hsa002200.36640490
115Platelet activation_Homo sapiens_hsa046110.36368971
116Vitamin B6 metabolism_Homo sapiens_hsa007500.32798071
117Legionellosis_Homo sapiens_hsa051340.32194921
118AMPK signaling pathway_Homo sapiens_hsa041520.31137655
119Tyrosine metabolism_Homo sapiens_hsa003500.31080647
120Melanoma_Homo sapiens_hsa052180.30974963
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.30658346
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.30539525
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29416229
124Wnt signaling pathway_Homo sapiens_hsa043100.29012656
125Measles_Homo sapiens_hsa051620.28830163
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28556519
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28240918
128Renal cell carcinoma_Homo sapiens_hsa052110.27752936
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26727397
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26260613
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25963939

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