ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-serine metabolic process (GO:0006563)	4.45144995
2	cell wall macromolecule catabolic process (GO:0016998)	4.24434369
3	serine family amino acid catabolic process (GO:0009071)	4.09641176
4	protein localization to kinetochore (GO:0034501)	3.95641576
5	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.84119705
6	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.84119705
7	serine family amino acid biosynthetic process (GO:0009070)	3.73856216
8	establishment of integrated proviral latency (GO:0075713)	3.67383376
9	cell wall macromolecule metabolic process (GO:0044036)	3.62625463
10	proteasome assembly (GO:0043248)	3.58117639
11	cullin deneddylation (GO:0010388)	3.53202978
12	DNA damage response, detection of DNA damage (GO:0042769)	3.53026866
13	glyoxylate metabolic process (GO:0046487)	3.51643684
14	serine family amino acid metabolic process (GO:0009069)	3.47002318
15	aldehyde catabolic process (GO:0046185)	3.46441802
16	glycine metabolic process (GO:0006544)	3.45421699
17	IMP biosynthetic process (GO:0006188)	3.45102483
18	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.42343563
19	cholesterol biosynthetic process (GO:0006695)	3.41006518
20	protein deneddylation (GO:0000338)	3.31319254
21	cardiac right ventricle morphogenesis (GO:0003215)	3.30772675
22	water-soluble vitamin biosynthetic process (GO:0042364)	3.25977325
23	protein localization to chromosome, centromeric region (GO:0071459)	3.18697011
24	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.13085014
25	termination of RNA polymerase III transcription (GO:0006386)	3.13085014
26	purine nucleobase biosynthetic process (GO:0009113)	3.06744331
27	regulation of helicase activity (GO:0051095)	3.05232339
28	sulfur amino acid biosynthetic process (GO:0000097)	3.01733954
29	nucleobase biosynthetic process (GO:0046112)	3.00458071
30	sterol biosynthetic process (GO:0016126)	2.96745028
31	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.96096187
32	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.96096187
33	rRNA modification (GO:0000154)	2.96066071
34	rRNA methylation (GO:0031167)	2.95205476
35	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.92953387
36	regulation of mitotic spindle checkpoint (GO:1903504)	2.92953387
37	L-methionine salvage (GO:0071267)	2.91970595
38	L-methionine biosynthetic process (GO:0071265)	2.91970595
39	amino acid salvage (GO:0043102)	2.91970595
40	chromatin remodeling at centromere (GO:0031055)	2.91960164
41	DNA double-strand break processing (GO:0000729)	2.87848147
42	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.86624793
43	DNA replication-dependent nucleosome assembly (GO:0006335)	2.82272670
44	DNA replication-dependent nucleosome organization (GO:0034723)	2.82272670
45	protein neddylation (GO:0045116)	2.81703925
46	branched-chain amino acid catabolic process (GO:0009083)	2.81034221
47	tRNA aminoacylation for protein translation (GO:0006418)	2.80826275
48	IMP metabolic process (GO:0046040)	2.80061180
49	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.79151746
50	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.78267938
51	cysteine metabolic process (GO:0006534)	2.77414431
52	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.77105442
53	tRNA aminoacylation (GO:0043039)	2.76162079
54	amino acid activation (GO:0043038)	2.76162079
55	establishment of viral latency (GO:0019043)	2.75674687
56	ribosome assembly (GO:0042255)	2.74274540
57	gonadal mesoderm development (GO:0007506)	2.73705942
58	CENP-A containing nucleosome assembly (GO:0034080)	2.73134754
59	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.71611128
60	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.71611128
61	isotype switching (GO:0045190)	2.71611128
62	DNA catabolic process, exonucleolytic (GO:0000738)	2.70213703
63	DNA ligation (GO:0006266)	2.69462490
64	formation of translation preinitiation complex (GO:0001731)	2.68552892
65	single strand break repair (GO:0000012)	2.68227404
66	regulation of secondary heart field cardioblast proliferation (GO:0003266)	2.67446279
67	regulation of cardioblast proliferation (GO:0003264)	2.67446279
68	DNA strand renaturation (GO:0000733)	2.66622771
69	chaperone-mediated protein transport (GO:0072321)	2.65143223
70	methionine metabolic process (GO:0006555)	2.64089367
71	S-adenosylmethionine metabolic process (GO:0046500)	2.62102861
72	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.61865438
73	DNA strand elongation involved in DNA replication (GO:0006271)	2.61021122
74	pseudouridine synthesis (GO:0001522)	2.59147677
75	intraciliary transport (GO:0042073)	2.57654864
76	non-recombinational repair (GO:0000726)	2.56501633
77	double-strand break repair via nonhomologous end joining (GO:0006303)	2.56501633
78	respiratory chain complex IV assembly (GO:0008535)	2.56403471
79	protein-cofactor linkage (GO:0018065)	2.55990214
80	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.54887057
81	DNA replication checkpoint (GO:0000076)	2.54364236
82	DNA strand elongation (GO:0022616)	2.53569430
83	spindle checkpoint (GO:0031577)	2.48612982
84	mitotic spindle checkpoint (GO:0071174)	2.47117712
85	regulation of gene silencing by RNA (GO:0060966)	2.46774813
86	regulation of posttranscriptional gene silencing (GO:0060147)	2.46774813
87	regulation of gene silencing by miRNA (GO:0060964)	2.46774813
88	histone H2A monoubiquitination (GO:0035518)	2.46279270
89	spliceosomal snRNP assembly (GO:0000387)	2.45589688
90	lactate metabolic process (GO:0006089)	2.44614434
91	histone exchange (GO:0043486)	2.44276981
92	termination of RNA polymerase I transcription (GO:0006363)	2.43959802
93	oxidative phosphorylation (GO:0006119)	2.42242376
94	methionine biosynthetic process (GO:0009086)	2.41947804
95	mitochondrial RNA metabolic process (GO:0000959)	2.41340338
96	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.40758758
97	bile acid biosynthetic process (GO:0006699)	2.40264448
98	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.38995012
99	L-alpha-amino acid transmembrane transport (GO:1902475)	2.38740168
100	isoprenoid biosynthetic process (GO:0008299)	2.38297881

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.47071496
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.20748317
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.47630172
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.25511149
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.18379335
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.14460718
7	E2F7_22180533_ChIP-Seq_HELA_Human	2.88828892
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.75199418
9	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.73960095
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.67179610
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.59386328
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.58186867
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.57024696
14	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.51668101
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.44718482
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.34651101
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.33690750
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.16415760
19	ZNF274_21170338_ChIP-Seq_K562_Hela	2.14660705
20	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.11274801
21	IRF1_19129219_ChIP-ChIP_H3396_Human	2.08431179
22	VDR_23849224_ChIP-Seq_CD4+_Human	2.08074865
23	DCP1A_22483619_ChIP-Seq_HELA_Human	2.07372661
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.07047943
25	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.96959453
26	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.95597268
27	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.93790406
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.93039116
29	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.92751342
30	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.89384640
31	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.87956379
32	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.86649417
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.86473732
34	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.75884875
35	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.75618923
36	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.68553095
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.67672775
38	TTF2_22483619_ChIP-Seq_HELA_Human	1.61307794
39	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.61181409
40	XRN2_22483619_ChIP-Seq_HELA_Human	1.60309725
41	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.59957011
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.59219018
43	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.59071865
44	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.58746655
45	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.58491329
46	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.57775098
47	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.57159933
48	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.56963280
49	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.54976183
50	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.49375593
51	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.47700286
52	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.46965710
53	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.46937161
54	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.46437516
55	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.46277096
56	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.45272983
57	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.45230206
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.43393230
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.42888122
60	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.42259859
61	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.34828848
62	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.34013445
63	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.30953750
64	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.29577348
65	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.26195414
66	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.21781221
67	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.21527089
68	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.21233689
69	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.18743564
70	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.17534189
71	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.16612463
72	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.16155781
73	EWS_26573619_Chip-Seq_HEK293_Human	1.16046717
74	VDR_22108803_ChIP-Seq_LS180_Human	1.15289461
75	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.11207875
76	TAF15_26573619_Chip-Seq_HEK293_Human	1.09807154
77	FUS_26573619_Chip-Seq_HEK293_Human	1.09103010
78	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.08889680
79	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.08417583
80	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.07434539
81	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.06523820
82	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.05745243
83	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.05554381
84	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.02547305
85	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.02442063
86	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.98306295
87	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.97204989
88	AR_21909140_ChIP-Seq_LNCAP_Human	0.96465579
89	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.96070186
90	P300_19829295_ChIP-Seq_ESCs_Human	0.93364758
91	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.93225123
92	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.92623241
93	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.90231519
94	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.88449490
95	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.87955602
96	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.85692327
97	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.85692327
98	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.85692327
99	KDM5A_27292631_Chip-Seq_BREAST_Human	0.84298775
100	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.83646394

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008058_abnormal_DNA_repair	3.21160899
2	MP0003806_abnormal_nucleotide_metabolis	2.98089091
3	MP0006072_abnormal_retinal_apoptosis	2.90789958
4	MP0003122_maternal_imprinting	2.75587816
5	MP0010094_abnormal_chromosome_stability	2.69428623
6	MP0008789_abnormal_olfactory_epithelium	2.56446154
7	MP0008877_abnormal_DNA_methylation	2.45658379
8	MP0005394_taste/olfaction_phenotype	2.36213698
9	MP0005499_abnormal_olfactory_system	2.36213698
10	MP0002090_abnormal_vision	2.18837400
11	MP0004957_abnormal_blastocyst_morpholog	2.17250742
12	MP0008932_abnormal_embryonic_tissue	2.12083626
13	MP0001984_abnormal_olfaction	2.09928611
14	MP0001293_anophthalmia	2.09328490
15	MP0002751_abnormal_autonomic_nervous	2.05935481
16	MP0006292_abnormal_olfactory_placode	2.05731915
17	MP0001529_abnormal_vocalization	2.00569832
18	MP0003693_abnormal_embryo_hatching	1.93589584
19	MP0003567_abnormal_fetal_cardiomyocyte	1.91717199
20	MP0005085_abnormal_gallbladder_physiolo	1.85375864
21	MP0002938_white_spotting	1.79327732
22	MP0003890_abnormal_embryonic-extraembry	1.72535247
23	MP0008995_early_reproductive_senescence	1.71323502
24	MP0003718_maternal_effect	1.67157368
25	MP0005253_abnormal_eye_physiology	1.66712217
26	MP0002697_abnormal_eye_size	1.62945938
27	MP0003186_abnormal_redox_activity	1.62869810
28	MP0003077_abnormal_cell_cycle	1.62209519
29	MP0003786_premature_aging	1.62127687
30	MP0003111_abnormal_nucleus_morphology	1.61604182
31	MP0008007_abnormal_cellular_replicative	1.61235270
32	MP0009697_abnormal_copulation	1.60535150
33	MP0002233_abnormal_nose_morphology	1.59851901
34	MP0000647_abnormal_sebaceous_gland	1.58839680
35	MP0002254_reproductive_system_inflammat	1.55039633
36	MP0002102_abnormal_ear_morphology	1.51914108
37	MP0003121_genomic_imprinting	1.49453549
38	MP0003880_abnormal_central_pattern	1.46377792
39	MP0006035_abnormal_mitochondrial_morpho	1.45737394
40	MP0002139_abnormal_hepatobiliary_system	1.44787832
41	MP0005365_abnormal_bile_salt	1.42916558
42	MP0010030_abnormal_orbit_morphology	1.40324861
43	MP0001764_abnormal_homeostasis	1.38938976
44	MP0004019_abnormal_vitamin_homeostasis	1.38177314
45	MP0003941_abnormal_skin_development	1.36444452
46	MP0005646_abnormal_pituitary_gland	1.29349523
47	MP0001324_abnormal_eye_pigmentation	1.28763578
48	MP0003937_abnormal_limbs/digits/tail_de	1.25158651
49	MP0001730_embryonic_growth_arrest	1.21382078
50	MP0004133_heterotaxia	1.20798281
51	MP0005551_abnormal_eye_electrophysiolog	1.19278211
52	MP0003119_abnormal_digestive_system	1.16998674
53	MP0003136_yellow_coat_color	1.16699312
54	MP0005391_vision/eye_phenotype	1.15600809
55	MP0008057_abnormal_DNA_replication	1.14359788
56	MP0005075_abnormal_melanosome_morpholog	1.14139302
57	MP0002163_abnormal_gland_morphology	1.11103428
58	MP0000631_abnormal_neuroendocrine_gland	1.10958959
59	MP0008875_abnormal_xenobiotic_pharmacok	1.07955151
60	MP0002736_abnormal_nociception_after	1.06098281
61	MP0002084_abnormal_developmental_patter	1.05789666
62	MP0001929_abnormal_gametogenesis	1.05459293
63	MP0003195_calcinosis	1.05218156
64	MP0004147_increased_porphyrin_level	1.05173388
65	MP0005332_abnormal_amino_acid	1.03923905
66	MP0005360_urolithiasis	1.03457009
67	MP0008872_abnormal_physiological_respon	1.01426181
68	MP0000358_abnormal_cell_content/	1.00509659
69	MP0006276_abnormal_autonomic_nervous	0.99561696
70	MP0001286_abnormal_eye_development	0.99145591
71	MP0001697_abnormal_embryo_size	0.98287765
72	MP0009780_abnormal_chondrocyte_physiolo	0.96389825
73	MP0002210_abnormal_sex_determination	0.94606992
74	MP0002085_abnormal_embryonic_tissue	0.94101848
75	MP0002234_abnormal_pharynx_morphology	0.93014917
76	MP0005248_abnormal_Harderian_gland	0.92932344
77	MP0005380_embryogenesis_phenotype	0.92263065
78	MP0001672_abnormal_embryogenesis/_devel	0.92263065
79	MP0000372_irregular_coat_pigmentation	0.91110227
80	MP0005408_hypopigmentation	0.90339671
81	MP0004197_abnormal_fetal_growth/weight/	0.90243971
82	MP0003252_abnormal_bile_duct	0.89777848
83	MP0003787_abnormal_imprinting	0.85799562
84	MP0003011_delayed_dark_adaptation	0.85540639
85	MP0005645_abnormal_hypothalamus_physiol	0.83823903
86	MP0002837_dystrophic_cardiac_calcinosis	0.83173886
87	MP0000653_abnormal_sex_gland	0.82472903
88	MP0001145_abnormal_male_reproductive	0.82320950
89	MP0005451_abnormal_body_composition	0.79902840
90	MP0000049_abnormal_middle_ear	0.79329432
91	MP0002160_abnormal_reproductive_system	0.78670580
92	MP0006036_abnormal_mitochondrial_physio	0.78096734
93	MP0001968_abnormal_touch/_nociception	0.77815277
94	MP0005379_endocrine/exocrine_gland_phen	0.77618293
95	MP0003698_abnormal_male_reproductive	0.76396397
96	MP0002653_abnormal_ependyma_morphology	0.76046078
97	MP0002111_abnormal_tail_morphology	0.76004980
98	MP0003984_embryonic_growth_retardation	0.75895974
99	MP0002088_abnormal_embryonic_growth/wei	0.74310489
100	MP0005195_abnormal_posterior_eye	0.73997082

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperglycinemia (HP:0002154)	4.62803781
2	Abnormality of glycine metabolism (HP:0010895)	3.45862834
3	Abnormality of serine family amino acid metabolism (HP:0010894)	3.45862834
4	Hyperglycinuria (HP:0003108)	3.32081322
5	Hypoplastic pelvis (HP:0008839)	3.30779813
6	Ependymoma (HP:0002888)	3.21240938
7	Colon cancer (HP:0003003)	3.05043524
8	True hermaphroditism (HP:0010459)	2.95349573
9	Pancreatic fibrosis (HP:0100732)	2.94738072
10	Abnormality of serum amino acid levels (HP:0003112)	2.87179965
11	Abnormality of methionine metabolism (HP:0010901)	2.85029211
12	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.80081153
13	Reduced antithrombin III activity (HP:0001976)	2.78405713
14	Pancreatic cysts (HP:0001737)	2.75741143
15	Bifid tongue (HP:0010297)	2.59837319
16	Chromsome breakage (HP:0040012)	2.57297466
17	Abnormality of glycolysis (HP:0004366)	2.55468385
18	Acute encephalopathy (HP:0006846)	2.49409630
19	Medial flaring of the eyebrow (HP:0010747)	2.46823594
20	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.45868205
21	Molar tooth sign on MRI (HP:0002419)	2.45707527
22	Abnormality of midbrain morphology (HP:0002418)	2.45707527
23	Methylmalonic acidemia (HP:0002912)	2.44226764
24	Methylmalonic aciduria (HP:0012120)	2.37913373
25	Congenital primary aphakia (HP:0007707)	2.35599557
26	Postaxial foot polydactyly (HP:0001830)	2.35435451
27	Chronic hepatic failure (HP:0100626)	2.33394837
28	Nephrogenic diabetes insipidus (HP:0009806)	2.32693364
29	Abnormality of the labia minora (HP:0012880)	2.32649099
30	Abnormality of the ileum (HP:0001549)	2.30343276
31	Meckel diverticulum (HP:0002245)	2.30012165
32	Gonadotropin excess (HP:0000837)	2.29062966
33	Acute necrotizing encephalopathy (HP:0006965)	2.27732070
34	Prolonged partial thromboplastin time (HP:0003645)	2.27149754
35	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.26135392
36	Duplicated collecting system (HP:0000081)	2.24087357
37	Increased serum pyruvate (HP:0003542)	2.22107193
38	Gait imbalance (HP:0002141)	2.21448433
39	Medulloblastoma (HP:0002885)	2.20193323
40	Rhabdomyosarcoma (HP:0002859)	2.19172772
41	Abnormality of the renal collecting system (HP:0004742)	2.18803776
42	Genital tract atresia (HP:0001827)	2.17859529
43	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.17817412
44	Exercise-induced muscle cramps (HP:0003710)	2.16115408
45	Median cleft lip (HP:0000161)	2.15100615
46	Intrahepatic cholestasis (HP:0001406)	2.13456370
47	Abnormality of the astrocytes (HP:0100707)	2.13146970
48	Astrocytoma (HP:0009592)	2.13146970
49	Vaginal atresia (HP:0000148)	2.08732566
50	Septo-optic dysplasia (HP:0100842)	2.07625104
51	Preaxial hand polydactyly (HP:0001177)	2.05752681
52	Abnormal mitochondria in muscle tissue (HP:0008316)	2.04364468
53	Increased hepatocellular lipid droplets (HP:0006565)	2.03600858
54	Increased CSF lactate (HP:0002490)	2.03143814
55	Horseshoe kidney (HP:0000085)	2.01994562
56	Type I transferrin isoform profile (HP:0003642)	2.01600981
57	Lipid accumulation in hepatocytes (HP:0006561)	1.98638131
58	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.97946689
59	Cerebral edema (HP:0002181)	1.96406954
60	Pancreatic islet-cell hyperplasia (HP:0004510)	1.95304226
61	Postnatal microcephaly (HP:0005484)	1.94660931
62	Abnormal gallbladder physiology (HP:0012438)	1.94623125
63	Cholecystitis (HP:0001082)	1.94623125
64	Lethargy (HP:0001254)	1.94072338
65	Cystic liver disease (HP:0006706)	1.92205219
66	Abnormal biliary tract physiology (HP:0012439)	1.91383575
67	Bile duct proliferation (HP:0001408)	1.91383575
68	Occipital encephalocele (HP:0002085)	1.90713187
69	Renal cortical cysts (HP:0000803)	1.89216456
70	Abnormality of chromosome stability (HP:0003220)	1.88236086
71	Nephronophthisis (HP:0000090)	1.87948480
72	Sclerocornea (HP:0000647)	1.87277345
73	Aplasia/hypoplasia of the humerus (HP:0006507)	1.86742810
74	Spastic diplegia (HP:0001264)	1.86688675
75	Mitochondrial inheritance (HP:0001427)	1.85899407
76	Broad foot (HP:0001769)	1.84323592
77	Glioma (HP:0009733)	1.84136626
78	Absent radius (HP:0003974)	1.81224214
79	Proximal tubulopathy (HP:0000114)	1.80310378
80	Poor coordination (HP:0002370)	1.79187922
81	Abnormal protein glycosylation (HP:0012346)	1.78985399
82	Abnormal glycosylation (HP:0012345)	1.78985399
83	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.78985399
84	Abnormal protein N-linked glycosylation (HP:0012347)	1.78985399
85	Anencephaly (HP:0002323)	1.78750031
86	Abnormal lung lobation (HP:0002101)	1.77758279
87	Multiple enchondromatosis (HP:0005701)	1.77688880
88	Abnormality of the preputium (HP:0100587)	1.76395734
89	Neoplasm of striated muscle (HP:0009728)	1.74697040
90	Agnosia (HP:0010524)	1.74212500
91	Absent forearm bone (HP:0003953)	1.73977714
92	Aplasia involving forearm bones (HP:0009822)	1.73977714
93	Abnormality of pyrimidine metabolism (HP:0004353)	1.72378729
94	Hypoglycemic coma (HP:0001325)	1.72329308
95	Postaxial hand polydactyly (HP:0001162)	1.72079451
96	Hypobetalipoproteinemia (HP:0003563)	1.70828936
97	Dandy-Walker malformation (HP:0001305)	1.70794104
98	Progressive macrocephaly (HP:0004481)	1.68991401
99	Tubulointerstitial nephritis (HP:0001970)	1.68970692
100	Short humerus (HP:0005792)	1.68751594

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	4.00485876
2	CDK19	3.70719266
3	TRIM28	3.37924649
4	SRPK1	2.82737041
5	TXK	2.64122608
6	EIF2AK1	2.59988211
7	PBK	2.35487719
8	ACVR1B	2.26638771
9	TSSK6	2.13158258
10	BUB1	2.09907473
11	EIF2AK3	1.98682811
12	NEK1	1.93447707
13	BCR	1.87902042
14	MOS	1.85453330
15	ZAK	1.80718038
16	MKNK1	1.78793660
17	BCKDK	1.76209392
18	VRK2	1.70132921
19	GRK7	1.69323754
20	MST4	1.65582521
21	TTK	1.64129718
22	PLK3	1.60567202
23	NME1	1.56640354
24	MKNK2	1.48634191
25	CSNK1G3	1.45344529
26	NUAK1	1.43890101
27	PINK1	1.41392731
28	CSNK1A1L	1.40964420
29	CSNK1G1	1.40373710
30	CDC7	1.39636609
31	VRK1	1.34154985
32	PLK1	1.31720270
33	TNIK	1.31245515
34	CSNK1G2	1.29938913
35	PLK4	1.28507284
36	OXSR1	1.27510352
37	BMPR1B	1.25709019
38	WEE1	1.24673160
39	STK38L	1.17531795
40	EPHA4	1.15218842
41	NEK2	1.13034835
42	STK10	1.10135502
43	STK16	1.07499728
44	DYRK3	1.06656452
45	MAP2K7	1.05186015
46	EIF2AK2	1.04261788
47	PASK	1.02920286
48	ERBB3	1.02145743
49	PLK2	1.02043032
50	FGFR1	0.99153201
51	TESK2	0.97903823
52	DAPK1	0.97882136
53	MAP3K4	0.96975730
54	STK39	0.96090963
55	PDK2	0.94845279
56	GRK5	0.94709023
57	RPS6KA4	0.94117901
58	ATR	0.90038554
59	TGFBR1	0.87259702
60	TAF1	0.86370713
61	DYRK2	0.83784540
62	AURKB	0.83283858
63	SIK3	0.79015191
64	PAK3	0.78119194
65	TGFBR2	0.76718003
66	GRK1	0.69389459
67	ATM	0.67401854
68	MAP4K2	0.67382928
69	CHEK1	0.61072722
70	FER	0.57065035
71	AKT2	0.57052735
72	AURKA	0.54600905
73	MAPK13	0.52373613
74	TLK1	0.52231048
75	CHEK2	0.50913172
76	INSRR	0.50559862
77	PRKCG	0.49691906
78	NME2	0.48741945
79	PRKCE	0.48223510
80	CSNK2A2	0.47654030
81	CSNK2A1	0.46523794
82	WNK4	0.46494096
83	FRK	0.44926138
84	KDR	0.43094547
85	PAK6	0.41914108
86	CDK14	0.40730988
87	OBSCN	0.39169674
88	PAK4	0.39023090
89	LMTK2	0.38771055
90	CDK9	0.38397688
91	BRSK1	0.37177644
92	FLT3	0.35454043
93	BRD4	0.35205573
94	CDK3	0.33450377
95	CSNK1E	0.32452998
96	CDK18	0.32340627
97	CSNK1A1	0.32215421
98	CDK2	0.31564282
99	CDK1	0.30626759
100	CDK11A	0.30234932

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.63391716
2	Proteasome_Homo sapiens_hsa03050	2.41361424
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.39124315
4	Steroid biosynthesis_Homo sapiens_hsa00100	2.30839552
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.29410251
6	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.27251896
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.26149719
8	Propanoate metabolism_Homo sapiens_hsa00640	2.25957396
9	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.24745293
10	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.20901581
11	Mismatch repair_Homo sapiens_hsa03430	2.19191590
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.17834127
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.15575873
14	RNA polymerase_Homo sapiens_hsa03020	2.10318821
15	DNA replication_Homo sapiens_hsa03030	2.02629972
16	Fatty acid elongation_Homo sapiens_hsa00062	1.77555292
17	Protein export_Homo sapiens_hsa03060	1.71839407
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.70401513
19	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.69770358
20	RNA transport_Homo sapiens_hsa03013	1.69417571
21	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.68339116
22	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.65436314
23	Pyruvate metabolism_Homo sapiens_hsa00620	1.65076679
24	One carbon pool by folate_Homo sapiens_hsa00670	1.63142196
25	Carbon metabolism_Homo sapiens_hsa01200	1.61395758
26	Butanoate metabolism_Homo sapiens_hsa00650	1.59795704
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.59753199
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.57197089
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.55948096
30	RNA degradation_Homo sapiens_hsa03018	1.54281524
31	Peroxisome_Homo sapiens_hsa04146	1.52546387
32	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.50758558
33	Base excision repair_Homo sapiens_hsa03410	1.49194683
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.48385467
35	Spliceosome_Homo sapiens_hsa03040	1.47029322
36	Basal transcription factors_Homo sapiens_hsa03022	1.44795211
37	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.42875130
38	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.42104311
39	Homologous recombination_Homo sapiens_hsa03440	1.37732879
40	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.32196585
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.31947272
42	Parkinsons disease_Homo sapiens_hsa05012	1.30675553
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.27137248
44	Folate biosynthesis_Homo sapiens_hsa00790	1.24645703
45	Oxidative phosphorylation_Homo sapiens_hsa00190	1.23299027
46	Arginine and proline metabolism_Homo sapiens_hsa00330	1.20738881
47	Ribosome_Homo sapiens_hsa03010	1.18708850
48	Fatty acid degradation_Homo sapiens_hsa00071	1.12035509
49	Nucleotide excision repair_Homo sapiens_hsa03420	1.10575440
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.08796944
51	beta-Alanine metabolism_Homo sapiens_hsa00410	1.07983276
52	Glutathione metabolism_Homo sapiens_hsa00480	1.07828131
53	Fatty acid metabolism_Homo sapiens_hsa01212	1.07291173
54	Arginine biosynthesis_Homo sapiens_hsa00220	1.06957096
55	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01593192
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.00055511
57	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.00055292
58	Retinol metabolism_Homo sapiens_hsa00830	0.98335428
59	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.93761219
60	Purine metabolism_Homo sapiens_hsa00230	0.93585292
61	Huntingtons disease_Homo sapiens_hsa05016	0.90369894
62	mRNA surveillance pathway_Homo sapiens_hsa03015	0.89480997
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85538189
64	Metabolic pathways_Homo sapiens_hsa01100	0.85478280
65	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.84081742
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.82486998
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.80273851
68	Phototransduction_Homo sapiens_hsa04744	0.79996353
69	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.79618149
70	Cell cycle_Homo sapiens_hsa04110	0.78813606
71	Phenylalanine metabolism_Homo sapiens_hsa00360	0.78285939
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.77117667
73	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.75383661
74	Pentose phosphate pathway_Homo sapiens_hsa00030	0.75138605
75	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.73181260
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64803151
77	Nitrogen metabolism_Homo sapiens_hsa00910	0.62617594
78	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.60799455
79	Sulfur metabolism_Homo sapiens_hsa00920	0.59538428
80	Linoleic acid metabolism_Homo sapiens_hsa00591	0.57011602
81	Tyrosine metabolism_Homo sapiens_hsa00350	0.54470713
82	Alzheimers disease_Homo sapiens_hsa05010	0.49500784
83	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.48155667
84	Caffeine metabolism_Homo sapiens_hsa00232	0.47894041
85	Sulfur relay system_Homo sapiens_hsa04122	0.46083402
86	Complement and coagulation cascades_Homo sapiens_hsa04610	0.43871298
87	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.43754506
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.43522948
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43296629
90	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.41824084
91	Oocyte meiosis_Homo sapiens_hsa04114	0.40736343
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.40599273
93	Histidine metabolism_Homo sapiens_hsa00340	0.39348103
94	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.37099162
95	p53 signaling pathway_Homo sapiens_hsa04115	0.33424074
96	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.32090528
97	Lysine degradation_Homo sapiens_hsa00310	0.31489388
98	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.31331306
99	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.31023400
100	Regulation of autophagy_Homo sapiens_hsa04140	0.30421408

RNF2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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