RNF32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains two RING ring finger motifs. RING finger motifs are present in a variety of functionally distinct proteins and are known to be involved in protein-DNA or protein-protein interactions. This gene was found to be expressed during spermatogenesis, most likely in spermatocytes and/or in spermatids. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.63686002
2axonemal dynein complex assembly (GO:0070286)9.51389086
3sperm motility (GO:0030317)9.18439088
4epithelial cilium movement (GO:0003351)8.84485880
5piRNA metabolic process (GO:0034587)8.64357656
6cilium movement (GO:0003341)8.34282727
7acrosome assembly (GO:0001675)8.31285015
8acrosome reaction (GO:0007340)8.11520467
9multicellular organism reproduction (GO:0032504)8.05523742
10sperm-egg recognition (GO:0035036)7.88732068
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.86137457
12motile cilium assembly (GO:0044458)7.77740851
13male meiosis (GO:0007140)7.51530948
14plasma membrane fusion (GO:0045026)7.48648836
15binding of sperm to zona pellucida (GO:0007339)7.23241864
16spermatid development (GO:0007286)7.19305053
17cell-cell recognition (GO:0009988)7.00766635
18cell wall macromolecule catabolic process (GO:0016998)6.88174871
19cell wall macromolecule metabolic process (GO:0044036)6.88174871
20regulation of cilium movement (GO:0003352)6.64215085
21synaptonemal complex organization (GO:0070193)6.62508303
22reproduction (GO:0000003)6.36225637
23DNA methylation involved in gamete generation (GO:0043046)6.05836924
24synaptonemal complex assembly (GO:0007130)6.05168183
25single fertilization (GO:0007338)5.74571819
26negative regulation of inclusion body assembly (GO:0090084)5.70604117
27male meiosis I (GO:0007141)5.46169434
28ventricular system development (GO:0021591)5.38963508
29protein localization to cilium (GO:0061512)5.23056633
30sperm capacitation (GO:0048240)5.22569006
31fertilization (GO:0009566)5.02985151
32intraciliary transport (GO:0042073)4.80819128
33calcium ion-dependent exocytosis (GO:0017156)4.72835810
34spermatogenesis (GO:0007283)4.71453534
35male gamete generation (GO:0048232)4.69529384
36axoneme assembly (GO:0035082)4.48623182
37microtubule severing (GO:0051013)4.44080634
38meiosis I (GO:0007127)4.40759837
39chromosome organization involved in meiosis (GO:0070192)4.39585017
40gamete generation (GO:0007276)4.35159609
41meiotic chromosome segregation (GO:0045132)4.25312822
42meiotic nuclear division (GO:0007126)4.23762834
43regulation of microtubule-based movement (GO:0060632)4.21040539
44regulation of inclusion body assembly (GO:0090083)4.20925430
45microtubule depolymerization (GO:0007019)4.17941545
46germ cell development (GO:0007281)4.16434792
47establishment of protein localization to Golgi (GO:0072600)4.09590027
48cell recognition (GO:0008037)4.08580045
49cellular ketone body metabolic process (GO:0046950)4.05869197
50cellular process involved in reproduction in multicellular organism (GO:0022412)4.05828584
51protein polyglutamylation (GO:0018095)4.05080922
52resolution of meiotic recombination intermediates (GO:0000712)3.79209854
53DNA synthesis involved in DNA repair (GO:0000731)3.78238530
54left/right pattern formation (GO:0060972)3.75082563
55protein targeting to Golgi (GO:0000042)3.73248408
56meiotic cell cycle (GO:0051321)3.70723590
57cilium organization (GO:0044782)3.70245528
58nonmotile primary cilium assembly (GO:0035058)3.64409339
59cilium assembly (GO:0042384)3.59693250
60reciprocal meiotic recombination (GO:0007131)3.58512485
61reciprocal DNA recombination (GO:0035825)3.58512485
62GTP biosynthetic process (GO:0006183)3.58057966
63DNA double-strand break processing (GO:0000729)3.56452767
64microtubule-based movement (GO:0007018)3.54192167
65cilium morphogenesis (GO:0060271)3.51420599
66ketone body metabolic process (GO:1902224)3.50826810
67rRNA methylation (GO:0031167)3.50071579
68nucleoside diphosphate phosphorylation (GO:0006165)3.49173344
69multicellular organismal reproductive process (GO:0048609)3.39637383
70retrograde transport, vesicle recycling within Golgi (GO:0000301)3.37594534
71seminiferous tubule development (GO:0072520)3.35334539
72photoreceptor cell maintenance (GO:0045494)3.34354132
73positive regulation of mitochondrial fission (GO:0090141)3.31909521
74cellular component assembly involved in morphogenesis (GO:0010927)3.27000772
75retinal cone cell development (GO:0046549)3.24480628
76regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.21663206
77organic cation transport (GO:0015695)3.20761020
78spermatid nucleus differentiation (GO:0007289)3.18797655
79pyrimidine dimer repair (GO:0006290)3.18683750
80regulation of meiosis I (GO:0060631)3.17629743
81synapsis (GO:0007129)3.12927749
82retinal rod cell development (GO:0046548)3.05968114
83coenzyme catabolic process (GO:0009109)3.04888412
84histone H3-K9 demethylation (GO:0033169)3.04050302
85regulation of acyl-CoA biosynthetic process (GO:0050812)3.03980289
86lactate metabolic process (GO:0006089)3.03897967
87protein localization to Golgi apparatus (GO:0034067)3.02954604
88intra-Golgi vesicle-mediated transport (GO:0006891)3.00524170
89UTP biosynthetic process (GO:0006228)2.97777352
90tryptophan catabolic process (GO:0006569)2.93245656
91indole-containing compound catabolic process (GO:0042436)2.93245656
92indolalkylamine catabolic process (GO:0046218)2.93245656
93urinary tract smooth muscle contraction (GO:0014848)2.92647509
94peptidyl-histidine modification (GO:0018202)2.92240834
95mannosylation (GO:0097502)2.91120021
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89325003
97rRNA modification (GO:0000154)2.88984571
98phosphatidylethanolamine metabolic process (GO:0046337)2.88381554
99single strand break repair (GO:0000012)2.86436974
100histone H2A acetylation (GO:0043968)2.83510461
101genitalia morphogenesis (GO:0035112)2.81625366
102phosphatidylethanolamine biosynthetic process (GO:0006646)2.79380382
103negative regulation of organelle assembly (GO:1902116)2.71299967
104microtubule polymerization or depolymerization (GO:0031109)2.70700911
105androgen biosynthetic process (GO:0006702)2.70636875
106regulation of cofactor metabolic process (GO:0051193)2.70406409
107regulation of coenzyme metabolic process (GO:0051196)2.70406409
108monoubiquitinated protein deubiquitination (GO:0035520)2.66818043
109multicellular organismal development (GO:0007275)2.64790818
110gene silencing by RNA (GO:0031047)2.64201311
111meiotic cell cycle process (GO:1903046)2.62886399
112ADP metabolic process (GO:0046031)2.62481820
113negative regulation of DNA recombination (GO:0045910)2.62429444
114left/right axis specification (GO:0070986)2.62307372
115dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.61410455
116microtubule bundle formation (GO:0001578)2.59989909
117UTP metabolic process (GO:0046051)2.58919963
118estrogen biosynthetic process (GO:0006703)2.58810335
119regulation of phosphoprotein phosphatase activity (GO:0043666)2.58186781
120centriole replication (GO:0007099)2.56777382
121calcium ion import (GO:0070509)2.55732243
122photoreceptor cell development (GO:0042461)2.54968218
123membrane depolarization during action potential (GO:0086010)2.54172759
124polyol catabolic process (GO:0046174)2.53778236
125protein K11-linked deubiquitination (GO:0035871)2.50802789
126ribonucleoprotein complex disassembly (GO:0032988)2.50745419
127sister chromatid cohesion (GO:0007062)2.50724574
128negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.48440872
129protein refolding (GO:0042026)2.46183924
130glycerol metabolic process (GO:0006071)2.41954337
131centriole assembly (GO:0098534)2.41219500
132chaperone-mediated protein complex assembly (GO:0051131)2.41088691
133alditol metabolic process (GO:0019400)2.40642422
134guanosine-containing compound biosynthetic process (GO:1901070)2.39831751
135regulation of protein polyubiquitination (GO:1902914)2.36483514
136positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.35267409
137regulation of spindle checkpoint (GO:0090231)2.34812676
138protein localization to synapse (GO:0035418)2.33676622
139positive regulation of meiosis (GO:0045836)2.33026959
140mitochondrial fission (GO:0000266)2.32068979
141neuron cell-cell adhesion (GO:0007158)2.30436587
142regulation of protein kinase A signaling (GO:0010738)2.28664047
143positive regulation of meiotic cell cycle (GO:0051446)2.24504056
144sex differentiation (GO:0007548)2.23099924
145cell projection assembly (GO:0030031)2.22906126
146cilium or flagellum-dependent cell motility (GO:0001539)12.4387896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.51267316
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.07371756
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.92149343
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.97241314
5IGF1R_20145208_ChIP-Seq_DFB_Human3.62100317
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.70201036
7GBX2_23144817_ChIP-Seq_PC3_Human2.63273012
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.43394282
9VDR_22108803_ChIP-Seq_LS180_Human2.26173194
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.24228707
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.23468986
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18918817
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18365723
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16324011
15TAF15_26573619_Chip-Seq_HEK293_Human2.15325197
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04094914
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04019137
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02888782
19ZNF274_21170338_ChIP-Seq_K562_Hela2.01415759
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.00818316
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00082615
22* REST_21632747_ChIP-Seq_MESCs_Mouse1.94401061
23VDR_23849224_ChIP-Seq_CD4+_Human1.94310801
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.90547462
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85155438
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.83484082
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.81320604
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80053128
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78195997
30EWS_26573619_Chip-Seq_HEK293_Human1.76912716
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75532316
32TP53_22573176_ChIP-Seq_HFKS_Human1.74029618
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73576794
34RNF2_27304074_Chip-Seq_NSC_Mouse1.71918480
35FUS_26573619_Chip-Seq_HEK293_Human1.69783960
36DCP1A_22483619_ChIP-Seq_HELA_Human1.67485578
37GABP_19822575_ChIP-Seq_HepG2_Human1.67012218
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65433923
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.65180138
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57232250
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.56929792
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.56244718
43* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53117939
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.51928978
45ERA_21632823_ChIP-Seq_H3396_Human1.51494198
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51431541
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.51034078
48SMAD4_21799915_ChIP-Seq_A2780_Human1.50727352
49ER_23166858_ChIP-Seq_MCF-7_Human1.47735839
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47490396
51KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.47264261
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45674651
53MYC_18940864_ChIP-ChIP_HL60_Human1.41856639
54MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40147113
55* TAL1_26923725_Chip-Seq_HPCs_Mouse1.39915254
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39611631
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39611631
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.39353157
59KDM5A_27292631_Chip-Seq_BREAST_Human1.38776797
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37796741
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37369311
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.36456299
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35932778
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35496577
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35111448
66TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.34231486
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32404450
68CBP_20019798_ChIP-Seq_JUKART_Human1.32404450
69KDM2B_26808549_Chip-Seq_REH_Human1.32277531
70HOXB7_26014856_ChIP-Seq_BT474_Human1.32005497
71P300_19829295_ChIP-Seq_ESCs_Human1.31699711
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31200167
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30819187
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30584376
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30067300
76FOXP3_21729870_ChIP-Seq_TREG_Human1.29874336
77TCF4_23295773_ChIP-Seq_U87_Human1.29203937
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.27741108
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.27661786
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27470927
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27387322
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26957800
83NCOR_22424771_ChIP-Seq_293T_Human1.26491832
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23786324
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23013785
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23000459
87* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22811472
88P53_22387025_ChIP-Seq_ESCs_Mouse1.22659300
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22002417
90SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20589625
91PHF8_20622853_ChIP-Seq_HELA_Human1.19736297
92EZH2_27294783_Chip-Seq_ESCs_Mouse1.19693354
93E2F1_17053090_ChIP-ChIP_MCF-7_Human1.19410765
94RAC3_21632823_ChIP-Seq_H3396_Human1.18339223
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.17975068
96STAT3_23295773_ChIP-Seq_U87_Human1.17951518
97* ELK4_26923725_Chip-Seq_MESODERM_Mouse1.17651979
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17171561
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.16974726
100DROSHA_22980978_ChIP-Seq_HELA_Human1.16104214
101OCT4_20526341_ChIP-Seq_ESCs_Human1.15725697
102THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15234399
103* REST_18959480_ChIP-ChIP_MESCs_Mouse1.14990965
104ETV1_20927104_ChIP-Seq_GIST48_Human1.14645669
105* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13450327
106SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13128177
107P300_18555785_Chip-Seq_ESCs_Mouse1.12800951
108RUNX2_22187159_ChIP-Seq_PCA_Human1.12523485
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12452889
110ERG_20517297_ChIP-Seq_VCAP_Human1.11929408
111RBPJ_21746931_ChIP-Seq_IB4_Human1.11120039
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11118874
113WDR5_24793694_ChIP-Seq_LNCAP_Human1.10697844
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.10657307
115MYC_19829295_ChIP-Seq_ESCs_Human1.10131966
116* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09314975
117EZH2_27304074_Chip-Seq_ESCs_Mouse1.09177377
118STAT3_18555785_Chip-Seq_ESCs_Mouse1.09172949
119SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09157310
120CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09000843
121AR_21572438_ChIP-Seq_LNCaP_Human1.08858586
122EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08095941
123POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07840472
124PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07070964
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06465514
126MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06156935
127OCT4_18555785_Chip-Seq_ESCs_Mouse1.06011356
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05813092
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05066073
130SOX9_26525672_Chip-Seq_HEART_Mouse1.04938078
131PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04739649
132BCAT_22108803_ChIP-Seq_LS180_Human1.04700859
133NFYB_21822215_ChIP-Seq_K562_Human1.04205231
134PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04079082
135GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04065055
136GATA3_21878914_ChIP-Seq_MCF-7_Human1.03776460
137CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03633219
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03250418
139NANOG_20526341_ChIP-Seq_ESCs_Human1.02511108
140* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01924883
141EZH2_27294783_Chip-Seq_NPCs_Mouse1.01642039
142RNF2_27304074_Chip-Seq_ESCs_Mouse1.01214717
143SOX2_18555785_Chip-Seq_ESCs_Mouse1.01025849
144GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.01022175
145* SMAD4_21741376_ChIP-Seq_EPCs_Human1.00737348
146NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00284536
147TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00243578
148TBL1_22424771_ChIP-Seq_293T_Human0.99964892
149STAT1_17558387_ChIP-Seq_HELA_Human0.99636998
150GATA3_26560356_Chip-Seq_TH1_Human0.99239946
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98916419
152AR_25329375_ChIP-Seq_VCAP_Human0.98692731
153KLF4_18555785_Chip-Seq_ESCs_Mouse0.98435425
154RARB_27405468_Chip-Seq_BRAIN_Mouse0.98299598
155HNFA_21074721_ChIP-Seq_CACO-2_Human0.97663349
156RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97335521
157CRX_20693478_ChIP-Seq_RETINA_Mouse0.96651451
158* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96090356
159CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95792736
160FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95020931
161FOXA1_25329375_ChIP-Seq_VCAP_Human0.95020931
162CBX2_22325352_ChIP-Seq_293T-Rex_Human0.94276276
163* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94097244
164ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93677941
165FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92970654
166XRN2_22483619_ChIP-Seq_HELA_Human0.92395382
167CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92309226
168RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92133670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.55104199
2MP0008877_abnormal_DNA_methylation4.50548585
3MP0003698_abnormal_male_reproductive4.08343488
4MP0005360_urolithiasis3.98676746
5MP0001929_abnormal_gametogenesis3.63420637
6MP0003880_abnormal_central_pattern3.43093811
7MP0002653_abnormal_ependyma_morphology2.95336800
8MP0004859_abnormal_synaptic_plasticity2.67950064
9MP0002210_abnormal_sex_determination2.51208463
10MP0009046_muscle_twitch2.40887267
11MP0001984_abnormal_olfaction2.25975220
12MP0002161_abnormal_fertility/fecundity2.19542567
13MP0003635_abnormal_synaptic_transmissio2.11896508
14MP0004270_analgesia2.11258856
15MP0001145_abnormal_male_reproductive2.09074200
16MP0003787_abnormal_imprinting1.97546234
17MP0008058_abnormal_DNA_repair1.91065938
18MP0009745_abnormal_behavioral_response1.89956762
19MP0000653_abnormal_sex_gland1.86290319
20MP0008875_abnormal_xenobiotic_pharmacok1.84052901
21MP0001968_abnormal_touch/_nociception1.82904831
22MP0002572_abnormal_emotion/affect_behav1.80322482
23MP0002160_abnormal_reproductive_system1.75828270
24MP0002063_abnormal_learning/memory/cond1.73640470
25MP0002064_seizures1.73007830
26MP0002736_abnormal_nociception_after1.71604797
27MP0002272_abnormal_nervous_system1.66837494
28MP0003718_maternal_effect1.64996409
29MP0001486_abnormal_startle_reflex1.62651752
30MP0005174_abnormal_tail_pigmentation1.62363223
31MP0008789_abnormal_olfactory_epithelium1.61426094
32MP0001440_abnormal_grooming_behavior1.60965064
33MP0005394_taste/olfaction_phenotype1.57978483
34MP0005499_abnormal_olfactory_system1.57978483
35MP0000778_abnormal_nervous_system1.57529290
36MP0002837_dystrophic_cardiac_calcinosis1.56287172
37MP0005646_abnormal_pituitary_gland1.55147861
38MP0002734_abnormal_mechanical_nocicepti1.53949028
39MP0001529_abnormal_vocalization1.53693449
40MP0008961_abnormal_basal_metabolism1.52247242
41MP0005551_abnormal_eye_electrophysiolog1.51821853
42MP0002138_abnormal_hepatobiliary_system1.46483864
43MP0002638_abnormal_pupillary_reflex1.37042899
44MP0005310_abnormal_salivary_gland1.36621034
45MP0005423_abnormal_somatic_nervous1.36600306
46MP0002928_abnormal_bile_duct1.33327107
47MP0002735_abnormal_chemical_nociception1.31441114
48MP0000569_abnormal_digit_pigmentation1.30751182
49MP0001661_extended_life_span1.30322185
50MP0003656_abnormal_erythrocyte_physiolo1.28085383
51MP0006036_abnormal_mitochondrial_physio1.25612527
52MP0002067_abnormal_sensory_capabilities1.24992017
53MP0006072_abnormal_retinal_apoptosis1.23913692
54MP0002822_catalepsy1.22189629
55MP0005623_abnormal_meninges_morphology1.20811719
56MP0000538_abnormal_urinary_bladder1.19354056
57MP0002909_abnormal_adrenal_gland1.18788722
58MP0002132_abnormal_respiratory_system1.18541744
59MP0004019_abnormal_vitamin_homeostasis1.17377659
60MP0001919_abnormal_reproductive_system1.16441417
61MP0005377_hearing/vestibular/ear_phenot1.15848167
62MP0003878_abnormal_ear_physiology1.15848167
63MP0002557_abnormal_social/conspecific_i1.15607933
64MP0006276_abnormal_autonomic_nervous1.14811689
65MP0000427_abnormal_hair_cycle1.14100844
66MP0005084_abnormal_gallbladder_morpholo1.14012449
67MP0001905_abnormal_dopamine_level1.12460184
68MP0003786_premature_aging1.12191393
69MP0010094_abnormal_chromosome_stability1.10432055
70MP0004742_abnormal_vestibular_system1.09337174
71MP0003329_amyloid_beta_deposits1.08670325
72MP0001764_abnormal_homeostasis1.07976168
73MP0003693_abnormal_embryo_hatching1.07606370
74MP0002184_abnormal_innervation1.06615141
75MP0002882_abnormal_neuron_morphology1.04065843
76MP0003136_yellow_coat_color1.03309997
77MP0006035_abnormal_mitochondrial_morpho1.03272079
78MP0000955_abnormal_spinal_cord1.02926004
79MP0000015_abnormal_ear_pigmentation1.02502376
80MP0005253_abnormal_eye_physiology1.01036835
81MP0000383_abnormal_hair_follicle1.00823711
82MP0002229_neurodegeneration1.00598290
83MP0004233_abnormal_muscle_weight1.00307940
84MP0002234_abnormal_pharynx_morphology0.99328396
85MP0005083_abnormal_biliary_tract0.98038377
86MP0001501_abnormal_sleep_pattern0.97554468
87MP0000631_abnormal_neuroendocrine_gland0.97026804
88MP0001188_hyperpigmentation0.97019953
89MP0002282_abnormal_trachea_morphology0.95796205
90MP0001970_abnormal_pain_threshold0.95030866
91MP0001502_abnormal_circadian_rhythm0.94837286
92MP0005386_behavior/neurological_phenoty0.94153914
93MP0004924_abnormal_behavior0.94153914
94MP0003122_maternal_imprinting0.93019841
95MP0005645_abnormal_hypothalamus_physiol0.92487372
96MP0002102_abnormal_ear_morphology0.92392802
97MP0004811_abnormal_neuron_physiology0.92289713
98MP0003315_abnormal_perineum_morphology0.92193134
99MP0002152_abnormal_brain_morphology0.91805564
100MP0001944_abnormal_pancreas_morphology0.91518866
101MP0002733_abnormal_thermal_nociception0.89176343
102MP0004142_abnormal_muscle_tone0.89141548
103MP0004885_abnormal_endolymph0.87894774
104MP0002139_abnormal_hepatobiliary_system0.86616172
105MP0001963_abnormal_hearing_physiology0.86388500
106MP0003121_genomic_imprinting0.86253203
107MP0003123_paternal_imprinting0.86141242
108MP0001756_abnormal_urination0.85834368
109MP0005332_abnormal_amino_acid0.85734277
110MP0002066_abnormal_motor_capabilities/c0.85284673
111MP0001485_abnormal_pinna_reflex0.85227954
112MP0002752_abnormal_somatic_nervous0.84899566
113MP0005171_absent_coat_pigmentation0.84501128
114MP0005389_reproductive_system_phenotype0.83900213
115MP0000358_abnormal_cell_content/0.83782242
116MP0003646_muscle_fatigue0.83261552
117MP0009697_abnormal_copulation0.83216085
118MP0000462_abnormal_digestive_system0.81565023
119MP0005647_abnormal_sex_gland0.81558002
120MP0008569_lethality_at_weaning0.80832922
121MP0010678_abnormal_skin_adnexa0.80262076
122MP0005391_vision/eye_phenotype0.80253080
123MP0001119_abnormal_female_reproductive0.80238261
124MP0003283_abnormal_digestive_organ0.79722944
125MP0003111_abnormal_nucleus_morphology0.78800568
126MP0003634_abnormal_glial_cell0.77735671
127MP0010386_abnormal_urinary_bladder0.77298235
128MP0001765_abnormal_ion_homeostasis0.77172581
129MP0003879_abnormal_hair_cell0.75391385
130MP0009780_abnormal_chondrocyte_physiolo0.74411450
131MP0008057_abnormal_DNA_replication0.74224928
132MP0003806_abnormal_nucleotide_metabolis0.74020383
133MP0003890_abnormal_embryonic-extraembry0.72731481
134MP0002277_abnormal_respiratory_mucosa0.72703547
135MP0001986_abnormal_taste_sensitivity0.72027888
136MP0000920_abnormal_myelination0.70707893
137MP0004145_abnormal_muscle_electrophysio0.69821843
138MP0003195_calcinosis0.69482769
139MP0004134_abnormal_chest_morphology0.69199471
140MP0003861_abnormal_nervous_system0.69160921
141MP0002876_abnormal_thyroid_physiology0.67588321
142MP0003953_abnormal_hormone_level0.67230634
143MP0000026_abnormal_inner_ear0.67026484
144MP0004133_heterotaxia0.66992371
145MP0001664_abnormal_digestion0.66742997
146MP0004043_abnormal_pH_regulation0.66268404
147MP0002078_abnormal_glucose_homeostasis0.65645199
148MP0005266_abnormal_metabolism0.64651196
149MP0005409_darkened_coat_color0.64426739
150MP0003631_nervous_system_phenotype0.63680655
151MP0005220_abnormal_exocrine_pancreas0.63440552
152MP0005195_abnormal_posterior_eye0.62342361
153MP0008995_early_reproductive_senescence0.61065292
154MP0003632_abnormal_nervous_system0.60447999
155MP0005379_endocrine/exocrine_gland_phen0.60044206
156MP0002163_abnormal_gland_morphology0.59845234
157MP0003633_abnormal_nervous_system0.59839619

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.84866987
2Abnormal respiratory epithelium morphology (HP:0012253)7.78203727
3Abnormal respiratory motile cilium morphology (HP:0005938)7.78203727
4Abnormal ciliary motility (HP:0012262)7.50987322
5Rhinitis (HP:0012384)7.22038842
6Chronic bronchitis (HP:0004469)6.16287030
7Infertility (HP:0000789)4.90547435
8Nephronophthisis (HP:0000090)4.50320079
9Bronchiectasis (HP:0002110)3.89095995
10Nasal polyposis (HP:0100582)3.88447196
11Medial flaring of the eyebrow (HP:0010747)3.64639620
12Abnormality of the renal medulla (HP:0100957)3.44743697
13Bronchitis (HP:0012387)3.07228812
14Abnormality of midbrain morphology (HP:0002418)3.07121660
15Molar tooth sign on MRI (HP:0002419)3.07121660
16Abnormality of the lower motor neuron (HP:0002366)3.04283663
17Reduced antithrombin III activity (HP:0001976)2.99034161
18Abnormality of the nasal mucosa (HP:0000433)2.90808730
19Gait imbalance (HP:0002141)2.80018562
20Congenital primary aphakia (HP:0007707)2.77491539
21Hypoplasia of the uterus (HP:0000013)2.75097839
22Tubulointerstitial nephritis (HP:0001970)2.72345457
23Abnormal protein glycosylation (HP:0012346)2.68520002
24Abnormal glycosylation (HP:0012345)2.68520002
25Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.68520002
26Abnormal protein N-linked glycosylation (HP:0012347)2.68520002
27Poikiloderma (HP:0001029)2.58852875
28Type I transferrin isoform profile (HP:0003642)2.57443579
29Aplasia/hypoplasia of the uterus (HP:0008684)2.56660096
30Bony spicule pigmentary retinopathy (HP:0007737)2.50749980
31Attenuation of retinal blood vessels (HP:0007843)2.49277457
32Pancreatic fibrosis (HP:0100732)2.48954836
33Amyotrophic lateral sclerosis (HP:0007354)2.48740059
34Gonadotropin excess (HP:0000837)2.45096688
35Oligodactyly (hands) (HP:0001180)2.45018768
36Postaxial foot polydactyly (HP:0001830)2.42568678
37Nephrogenic diabetes insipidus (HP:0009806)2.42267017
38Recurrent otitis media (HP:0000403)2.41891920
39Recurrent sinusitis (HP:0011108)2.40432939
40Male pseudohermaphroditism (HP:0000037)2.39560986
41Fibular hypoplasia (HP:0003038)2.38665286
42Male infertility (HP:0003251)2.38582125
43Tubular atrophy (HP:0000092)2.38260584
44Facial hemangioma (HP:0000329)2.35460957
45Genital tract atresia (HP:0001827)2.34888982
46Vaginal atresia (HP:0000148)2.32415100
47True hermaphroditism (HP:0010459)2.28898334
48Cerebellar dysplasia (HP:0007033)2.27908168
49Retinal dysplasia (HP:0007973)2.25767701
50Postaxial hand polydactyly (HP:0001162)2.19368105
51Tubulointerstitial abnormality (HP:0001969)2.17773842
52Congenital stationary night blindness (HP:0007642)2.17213860
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16697361
54Abnormality of alanine metabolism (HP:0010916)2.16697361
55Hyperalaninemia (HP:0003348)2.16697361
56Abnormality of the intrinsic pathway (HP:0010989)2.14540579
57Severe muscular hypotonia (HP:0006829)2.13673159
58Gaze-evoked nystagmus (HP:0000640)2.09597149
59Abnormality of lateral ventricle (HP:0030047)2.09487155
60Renal cortical cysts (HP:0000803)2.08634995
61Retinitis pigmentosa (HP:0000510)2.04061700
62Congenital hepatic fibrosis (HP:0002612)2.02196455
63Oculomotor apraxia (HP:0000657)2.02059326
64Generalized aminoaciduria (HP:0002909)2.01928274
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.9069825
66Dynein arm defect of respiratory motile cilia (HP:0012255)10.4809457
67Absent/shortened dynein arms (HP:0200106)10.4809457
68Poor coordination (HP:0002370)1.99071317
69Focal motor seizures (HP:0011153)1.98809854
70Abnormal spermatogenesis (HP:0008669)1.97391289
71Aplasia/Hypoplasia of the lens (HP:0008063)1.95857596
72Absent speech (HP:0001344)1.94928949
73Urinary urgency (HP:0000012)1.94233311
74Stage 5 chronic kidney disease (HP:0003774)1.93571975
75Supernumerary spleens (HP:0009799)1.91982463
76Abnormality of DNA repair (HP:0003254)1.89509263
77Pigmentary retinal degeneration (HP:0001146)1.88977677
78Anencephaly (HP:0002323)1.88333279
79Epileptic encephalopathy (HP:0200134)1.87934055
80Polydipsia (HP:0001959)1.86237004
81Abnormal drinking behavior (HP:0030082)1.86237004
82Pancreatic cysts (HP:0001737)1.85605874
83Fetal akinesia sequence (HP:0001989)1.84789622
84Abnormality of the corticospinal tract (HP:0002492)1.84484950
85Neurofibrillary tangles (HP:0002185)1.83162040
86Prominent nasal bridge (HP:0000426)1.82559824
87Abnormality of the renal cortex (HP:0011035)1.81684180
88Cystic liver disease (HP:0006706)1.81402121
89Ketosis (HP:0001946)1.81035571
90Pachygyria (HP:0001302)1.80773801
91Aplasia/Hypoplasia of the tongue (HP:0010295)1.80687212
92Rib fusion (HP:0000902)1.79774769
93Abnormality of dentin (HP:0010299)1.79617582
94Type II lissencephaly (HP:0007260)1.77827368
95Abnormality of permanent molar morphology (HP:0011071)1.77049196
96Abnormality of the dental root (HP:0006486)1.77049196
97Taurodontia (HP:0000679)1.77049196
98Ketoacidosis (HP:0001993)1.75794301
99Aplasia/Hypoplasia of the fibula (HP:0006492)1.74454905
100Genetic anticipation (HP:0003743)1.71737876
101Multicystic kidney dysplasia (HP:0000003)1.69967885
102Facial cleft (HP:0002006)1.69480513
103Decreased testicular size (HP:0008734)1.68356165
104Impaired proprioception (HP:0010831)1.68171224
105Dyskinesia (HP:0100660)1.66533707
106Median cleft lip (HP:0000161)1.66292620
107Atonic seizures (HP:0010819)1.66267248
108Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65661470
109Abnormality of vitamin B metabolism (HP:0004340)1.64402303
110Abnormality of molar (HP:0011077)1.64140467
111Abnormality of molar morphology (HP:0011070)1.64140467
112Hypoplasia of the pons (HP:0012110)1.64120199
113Horizontal nystagmus (HP:0000666)1.63028307
114Congenital malformation of the right heart (HP:0011723)1.62185782
115Double outlet right ventricle (HP:0001719)1.62185782
116Abnormality of the dental pulp (HP:0006479)1.61612240
117Hyperventilation (HP:0002883)1.61491433
118Tubulointerstitial fibrosis (HP:0005576)1.60822999
119Polyuria (HP:0000103)1.60635603
120Anteriorly placed anus (HP:0001545)1.60583743
121Methylmalonic acidemia (HP:0002912)1.60080473
122Progressive cerebellar ataxia (HP:0002073)1.59847727
123Myokymia (HP:0002411)1.59283022
124Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.59277568
125Degeneration of the lateral corticospinal tracts (HP:0002314)1.58901510
126Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.58901510
127Asthma (HP:0002099)1.58689750
128Sclerocornea (HP:0000647)1.57368489
129Bifid tongue (HP:0010297)1.56834175
130Sensory axonal neuropathy (HP:0003390)1.54528182
131Short ribs (HP:0000773)1.54004857
132Abnormality of ocular smooth pursuit (HP:0000617)1.53646419
133Focal seizures (HP:0007359)1.51744366
134Occipital encephalocele (HP:0002085)1.48923326
135Dyschromatopsia (HP:0007641)1.47029655
136Preaxial hand polydactyly (HP:0001177)1.45953072
137Azoospermia (HP:0000027)1.43909556
138Broad distal phalanx of finger (HP:0009836)1.43514198
139Chronic hepatic failure (HP:0100626)1.43273163
140Cerebral inclusion bodies (HP:0100314)1.43264476
141Specific learning disability (HP:0001328)1.40919325
142Abnormality of renal excretion (HP:0011036)1.39176780
143Lissencephaly (HP:0001339)1.39093710
144Renal dysplasia (HP:0000110)1.38749946
145Abnormal biliary tract physiology (HP:0012439)1.37770521
146Bile duct proliferation (HP:0001408)1.37770521
147Widely spaced teeth (HP:0000687)1.36425100
148Decreased central vision (HP:0007663)1.35597295
149Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.34517677
150Absent epiphyses (HP:0010577)1.34517677
151Chronic sinusitis (HP:0011109)1.34435405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.76931300
2PDK36.76931300
3FRK4.68574843
4PDK24.24189311
5PRKD33.70333468
6STK393.36868095
7PNCK3.14412040
8TESK12.79405341
9WNK42.75374560
10MAP4K22.50863967
11ICK2.44718685
12PKN22.34491642
13EPHA42.17508233
14PTK2B2.12781144
15MAPK151.98360944
16CASK1.92503310
17NTRK31.84131705
18FLT31.66936131
19TNIK1.52628769
20TRIM281.50450660
21PLK41.50326349
22TAOK31.44607773
23MAP3K41.43422439
24EIF2AK11.40861728
25MARK31.39177859
26ERBB31.38400500
27ZAK1.34175940
28MAP2K71.34087639
29OXSR11.33829691
30CDK81.31263041
31AKT31.25826885
32WNK11.22646387
33RPS6KA41.22018634
34PRPF4B1.15320214
35STK381.14896942
36BCR1.13766375
37BRAF1.10816787
38MET1.10750481
39RPS6KA51.06248576
40NTRK21.05818649
41TXK1.04297375
42BRD41.02050483
43CCNB10.97859693
44BMPR1B0.96666059
45WNK30.95968419
46MARK10.94744718
47ARAF0.92975073
48TYRO30.92030537
49TLK10.91546848
50MAPK130.90174493
51MAP3K90.89297034
52MST40.87875200
53KSR10.80186458
54ACVR1B0.77928751
55PAK60.77278202
56MKNK20.77202379
57CAMK2B0.77079855
58CDK190.75262836
59PBK0.74720238
60CAMK2A0.74410574
61CSNK1A1L0.74029964
62PRKCG0.73574128
63LMTK20.73276133
64MINK10.72143526
65PLK20.71206657
66STK160.70371524
67CSNK1G20.69751165
68ADRBK20.69376339
69ATR0.68660091
70GRK10.68060643
71TNK20.68002288
72MUSK0.67153696
73ATM0.65403508
74CSNK1G30.64036158
75NEK20.62885170
76EPHA30.61768110
77IRAK10.61289823
78PDK10.58682083
79RPS6KB10.58334728
80TGFBR10.57488382
81ITK0.57389209
82NME10.55111997
83SIK20.54916694
84SIK30.54153564
85SGK4940.54099388
86SGK2230.54099388
87PLK10.53976628
88CDK120.53504299
89BCKDK0.51888999
90PINK10.51520825
91CDC70.51479070
92CDK50.51434014
93DAPK20.51362329
94TEC0.49893866
95MST1R0.49369747
96NEK60.48843577
97CDK30.48597542
98EIF2AK30.45604487
99STK38L0.44989863
100CAMK2D0.44574495
101CDK180.43855774
102MAPKAPK50.43740846
103BLK0.43669455
104RET0.43589778
105GRK50.43492423
106CDK140.41963428
107CAMK10.41382372
108UHMK10.41274853
109MAP2K40.41126667
110CDK90.41012367
111AURKA0.40850584
112BMPR20.40767211
113PRKAA10.40616595
114IRAK20.40086648
115PASK0.39373371
116CDK150.38082586
117MAP3K120.37928023
118BMX0.37730033
119STK30.36942084
120CHEK20.36095388
121MAP2K60.35649528
122CSNK1G10.35631037
123DYRK1A0.35538851
124STK110.34803889
125CAMK40.34451146
126SGK20.33858533
127PAK30.33678157
128GRK60.33163419
129NTRK10.32701080
130PKN10.32654619
131CAMK2G0.32642763
132PRKG10.31041730
133CDK11A0.30922092
134FGFR20.30699926
135PRKCE0.30242874
136INSRR0.30152663
137MARK20.29087406
138PDPK10.29055814
139KSR20.27718782
140RIPK40.27470682
141DYRK30.26425814
142CHEK10.26110004
143PRKCQ0.26024925
144CAMKK10.25912898
145TTK0.25626817
146PRKACA0.23468039
147PRKD20.23072463
148CAMK1G0.20163991
149CAMKK20.19781065
150PRKCZ0.19467710
151SGK10.18115775
152GRK70.18107764

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.19507555
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.00496905
3Nicotine addiction_Homo sapiens_hsa050332.92040257
4Amphetamine addiction_Homo sapiens_hsa050312.70050267
5Vitamin B6 metabolism_Homo sapiens_hsa007502.63442904
6Pyruvate metabolism_Homo sapiens_hsa006202.56107124
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.54859693
8Selenocompound metabolism_Homo sapiens_hsa004502.34648889
9Huntingtons disease_Homo sapiens_hsa050162.33010428
10Homologous recombination_Homo sapiens_hsa034402.32166685
11Long-term potentiation_Homo sapiens_hsa047202.26938833
12Olfactory transduction_Homo sapiens_hsa047402.25474197
13Synaptic vesicle cycle_Homo sapiens_hsa047212.22852945
14Collecting duct acid secretion_Homo sapiens_hsa049662.06516232
15Circadian entrainment_Homo sapiens_hsa047132.01968682
16Glutamatergic synapse_Homo sapiens_hsa047242.00165742
17Renin secretion_Homo sapiens_hsa049241.95060476
18Oxidative phosphorylation_Homo sapiens_hsa001901.92772292
19Basal transcription factors_Homo sapiens_hsa030221.87060208
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.83247549
21Taste transduction_Homo sapiens_hsa047421.82781190
22Dorso-ventral axis formation_Homo sapiens_hsa043201.81970566
23Morphine addiction_Homo sapiens_hsa050321.80480836
24Glucagon signaling pathway_Homo sapiens_hsa049221.78280111
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.75358226
26Phototransduction_Homo sapiens_hsa047441.72173537
27Insulin secretion_Homo sapiens_hsa049111.71552961
28Cardiac muscle contraction_Homo sapiens_hsa042601.70680702
29Oocyte meiosis_Homo sapiens_hsa041141.68885666
30Dopaminergic synapse_Homo sapiens_hsa047281.63836658
31GABAergic synapse_Homo sapiens_hsa047271.58221294
32Linoleic acid metabolism_Homo sapiens_hsa005911.57961902
33RNA polymerase_Homo sapiens_hsa030201.57768551
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.53118703
35Nucleotide excision repair_Homo sapiens_hsa034201.52914974
36Ether lipid metabolism_Homo sapiens_hsa005651.52191044
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50764607
38Propanoate metabolism_Homo sapiens_hsa006401.49536058
39Alzheimers disease_Homo sapiens_hsa050101.47782329
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47110623
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45466504
42Calcium signaling pathway_Homo sapiens_hsa040201.44149911
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.37296532
44Salivary secretion_Homo sapiens_hsa049701.37056674
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37040547
46RNA transport_Homo sapiens_hsa030131.35652442
47Cocaine addiction_Homo sapiens_hsa050301.35251171
48Vibrio cholerae infection_Homo sapiens_hsa051101.34320817
49Parkinsons disease_Homo sapiens_hsa050121.33791120
50Mismatch repair_Homo sapiens_hsa034301.32589973
51Serotonergic synapse_Homo sapiens_hsa047261.30073427
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27857686
53beta-Alanine metabolism_Homo sapiens_hsa004101.27401989
54Peroxisome_Homo sapiens_hsa041461.26975804
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.26727662
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24472372
57Fatty acid biosynthesis_Homo sapiens_hsa000611.24126966
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24017763
59RNA degradation_Homo sapiens_hsa030181.22771717
60Sulfur relay system_Homo sapiens_hsa041221.20057353
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19045214
62Fanconi anemia pathway_Homo sapiens_hsa034601.17940049
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16011277
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12984899
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09774470
66Gastric acid secretion_Homo sapiens_hsa049711.07549517
67Chemical carcinogenesis_Homo sapiens_hsa052041.07252415
68Glycerophospholipid metabolism_Homo sapiens_hsa005641.07063018
69Tryptophan metabolism_Homo sapiens_hsa003801.04291130
70Axon guidance_Homo sapiens_hsa043601.02216177
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00995006
72cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00457681
73Long-term depression_Homo sapiens_hsa047300.98152058
74cAMP signaling pathway_Homo sapiens_hsa040240.96806860
75Glycerolipid metabolism_Homo sapiens_hsa005610.94746365
76Oxytocin signaling pathway_Homo sapiens_hsa049210.94697584
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94434622
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94250610
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93932247
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93053172
81Estrogen signaling pathway_Homo sapiens_hsa049150.92486317
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90352230
83Pyrimidine metabolism_Homo sapiens_hsa002400.89163777
84Cholinergic synapse_Homo sapiens_hsa047250.88325060
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86920902
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86742789
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86042771
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.84904896
89Phenylalanine metabolism_Homo sapiens_hsa003600.83682057
90Base excision repair_Homo sapiens_hsa034100.82733935
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79644457
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79186781
93Glutathione metabolism_Homo sapiens_hsa004800.77694382
94mRNA surveillance pathway_Homo sapiens_hsa030150.77054576
95Nitrogen metabolism_Homo sapiens_hsa009100.75945743
96Purine metabolism_Homo sapiens_hsa002300.74601949
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73826799
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73229952
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73160145
100Pancreatic secretion_Homo sapiens_hsa049720.72505653
101Sphingolipid metabolism_Homo sapiens_hsa006000.71532026
102Mineral absorption_Homo sapiens_hsa049780.70637019
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70304762
104ABC transporters_Homo sapiens_hsa020100.69956314
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67786899
106Hedgehog signaling pathway_Homo sapiens_hsa043400.66196181
107Protein export_Homo sapiens_hsa030600.65541443
108Wnt signaling pathway_Homo sapiens_hsa043100.64565029
109Thyroid hormone synthesis_Homo sapiens_hsa049180.64515689
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64058069
111Alcoholism_Homo sapiens_hsa050340.63966311
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61094902
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60481926
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59718150
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.59055273
116Regulation of autophagy_Homo sapiens_hsa041400.56178129
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56157061
118Folate biosynthesis_Homo sapiens_hsa007900.55905175
119Melanogenesis_Homo sapiens_hsa049160.55868786
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55679942
121Fatty acid metabolism_Homo sapiens_hsa012120.55575644
122Legionellosis_Homo sapiens_hsa051340.55388577
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55352159
124Gap junction_Homo sapiens_hsa045400.55323161
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.55109527
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54161152
127Sulfur metabolism_Homo sapiens_hsa009200.53487982
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53320749
129Lysine degradation_Homo sapiens_hsa003100.52340592
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52155053
131Inositol phosphate metabolism_Homo sapiens_hsa005620.50652543
132Arginine and proline metabolism_Homo sapiens_hsa003300.50350613
133Retinol metabolism_Homo sapiens_hsa008300.49176372
134mTOR signaling pathway_Homo sapiens_hsa041500.49092054
135Non-homologous end-joining_Homo sapiens_hsa034500.47737659
136Pentose phosphate pathway_Homo sapiens_hsa000300.47552832
137Fatty acid elongation_Homo sapiens_hsa000620.47160229
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44718049
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40306365
140Steroid biosynthesis_Homo sapiens_hsa001000.39784855
141GnRH signaling pathway_Homo sapiens_hsa049120.38992230
142Tight junction_Homo sapiens_hsa045300.38835219
143Vitamin digestion and absorption_Homo sapiens_hsa049770.38144096
144Circadian rhythm_Homo sapiens_hsa047100.37527597
145Type II diabetes mellitus_Homo sapiens_hsa049300.37346351
146Fatty acid degradation_Homo sapiens_hsa000710.37226041
147Tyrosine metabolism_Homo sapiens_hsa003500.37165771
148AMPK signaling pathway_Homo sapiens_hsa041520.36583804
149Fructose and mannose metabolism_Homo sapiens_hsa000510.36411809
150N-Glycan biosynthesis_Homo sapiens_hsa005100.35864913
151ErbB signaling pathway_Homo sapiens_hsa040120.33981733
152Ovarian steroidogenesis_Homo sapiens_hsa049130.33864356
153Metabolic pathways_Homo sapiens_hsa011000.32461697
154Arachidonic acid metabolism_Homo sapiens_hsa005900.31348265
155MAPK signaling pathway_Homo sapiens_hsa040100.30327557

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