RNF34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)4.73638085
2piRNA metabolic process (GO:0034587)4.65680372
3chaperone-mediated protein transport (GO:0072321)4.29935921
4protein localization to chromosome, centromeric region (GO:0071459)4.15337081
5synapsis (GO:0007129)4.09055228
6DNA strand elongation involved in DNA replication (GO:0006271)3.96372500
7positive regulation of histone H3-K4 methylation (GO:0051571)3.93933185
8telomere maintenance via semi-conservative replication (GO:0032201)3.93089796
9DNA strand elongation (GO:0022616)3.85222161
10regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.64708140
11regulation of mitotic spindle checkpoint (GO:1903504)3.64708140
12negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.54176427
13DNA double-strand break processing (GO:0000729)3.49702896
14male meiosis (GO:0007140)3.48844512
15positive regulation of chromosome segregation (GO:0051984)3.45985207
16telomere maintenance via recombination (GO:0000722)3.44218413
17DNA methylation involved in gamete generation (GO:0043046)3.43449401
18attachment of spindle microtubules to kinetochore (GO:0008608)3.43067790
19DNA ligation (GO:0006266)3.42097888
20L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.41749217
21somatic diversification of immune receptors via somatic mutation (GO:0002566)3.39794617
22somatic hypermutation of immunoglobulin genes (GO:0016446)3.39794617
23nucleotide-excision repair, DNA gap filling (GO:0006297)3.39220258
24DNA catabolic process, exonucleolytic (GO:0000738)3.38024207
25regulation of female gonad development (GO:2000194)3.37362764
26DNA deamination (GO:0045006)3.35702071
27regulation of histone H3-K9 methylation (GO:0051570)3.34112923
28negative regulation of meiosis (GO:0045835)3.34017170
29protein localization to chromosome (GO:0034502)3.31024081
30positive regulation of mitotic sister chromatid separation (GO:1901970)3.28205406
31positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.28205406
32positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.28205406
33replication fork processing (GO:0031297)3.26300306
34mitotic spindle checkpoint (GO:0071174)3.25527710
35meiotic cell cycle (GO:0051321)3.24470755
36mitotic recombination (GO:0006312)3.24166505
37telomere maintenance via telomere lengthening (GO:0010833)3.24084689
38postreplication repair (GO:0006301)3.23292027
39regulation of meiosis (GO:0040020)3.23058429
40kinetochore organization (GO:0051383)3.22406701
41positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21516651
42regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.19478429
43regulation of mitotic metaphase/anaphase transition (GO:0030071)3.19478429
44histone mRNA metabolic process (GO:0008334)3.18814187
45female gamete generation (GO:0007292)3.17393932
46DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.16953390
477-methylguanosine mRNA capping (GO:0006370)3.16709925
48regulation of cellular amino acid metabolic process (GO:0006521)3.14767904
49signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13725019
50signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13725019
51signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13725019
52negative regulation of mitotic sister chromatid separation (GO:2000816)3.13111534
53negative regulation of mitotic sister chromatid segregation (GO:0033048)3.13111534
54negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.13111534
55negative regulation of sister chromatid segregation (GO:0033046)3.13111534
56negative regulation of chromosome segregation (GO:0051985)3.11954794
57RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11797085
58RNA capping (GO:0036260)3.11771896
597-methylguanosine RNA capping (GO:0009452)3.11771896
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.11379795
61signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.11379795
62base-excision repair (GO:0006284)3.10951141
63G1/S transition of mitotic cell cycle (GO:0000082)3.10028383
64cell cycle G1/S phase transition (GO:0044843)3.10028383
65CENP-A containing nucleosome assembly (GO:0034080)3.09528017
66negative regulation of DNA-dependent DNA replication (GO:2000104)3.09132535
67positive regulation of ligase activity (GO:0051351)3.08499868
68regulation of mitotic sister chromatid separation (GO:0010965)3.08112191
69regulation of mitotic sister chromatid segregation (GO:0033047)3.08112191
70regulation of sister chromatid segregation (GO:0033045)3.08112191
71mitotic metaphase plate congression (GO:0007080)3.07730972
72regulation of chromosome segregation (GO:0051983)3.03492017
73chromatin remodeling at centromere (GO:0031055)3.03341344
74centriole replication (GO:0007099)3.02991077
75pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.02201613
76signal transduction involved in DNA damage checkpoint (GO:0072422)3.00585396
77signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00585396
78regulation of spindle organization (GO:0090224)3.00389960
79spliceosomal snRNP assembly (GO:0000387)2.99413823
80signal transduction involved in cell cycle checkpoint (GO:0072395)2.98791813
81regulation of meiosis I (GO:0060631)2.95126148
82maturation of 5.8S rRNA (GO:0000460)2.94878596
83protein deneddylation (GO:0000338)2.89166565
84regulation of DNA methylation (GO:0044030)2.87033289
85mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.82638700
86DNA replication-independent nucleosome assembly (GO:0006336)2.80971769
87DNA replication-independent nucleosome organization (GO:0034724)2.80971769
88neuron cell-cell adhesion (GO:0007158)2.79815734
89negative regulation of meiotic cell cycle (GO:0051447)2.79619108
90protein K6-linked ubiquitination (GO:0085020)2.78650196
91histone exchange (GO:0043486)2.75312722
92termination of RNA polymerase III transcription (GO:0006386)2.73881805
93transcription elongation from RNA polymerase III promoter (GO:0006385)2.73881805
94regulation of meiotic cell cycle (GO:0051445)2.67048326
95metaphase plate congression (GO:0051310)2.64657250
96base-excision repair, AP site formation (GO:0006285)2.64253311
97transcription elongation from RNA polymerase II promoter (GO:0006368)2.61488959
98establishment of integrated proviral latency (GO:0075713)2.59002029
99DNA replication checkpoint (GO:0000076)2.58463129
100regulation of RIG-I signaling pathway (GO:0039535)2.58330049
101establishment of chromosome localization (GO:0051303)2.58019244
102mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.56992271
103pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.55638754
104histone H2A monoubiquitination (GO:0035518)2.55573043
105protein neddylation (GO:0045116)2.55070702
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.53476385
107regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.52561536
108protein complex biogenesis (GO:0070271)2.51919254
109cullin deneddylation (GO:0010388)2.50233186
110establishment of protein localization to mitochondrial membrane (GO:0090151)2.49894775
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.49643471
112mitochondrial respiratory chain complex I assembly (GO:0032981)2.49643471
113NADH dehydrogenase complex assembly (GO:0010257)2.49643471
114DNA-templated transcription, elongation (GO:0006354)2.47399821
115establishment of viral latency (GO:0019043)2.44900019
116transcription elongation from RNA polymerase I promoter (GO:0006362)2.44348840
117positive regulation of meiosis (GO:0045836)2.42032476
118histone H2A ubiquitination (GO:0033522)2.40677901
119microtubule severing (GO:0051013)2.40619061
120proteasome assembly (GO:0043248)2.40377055
121ATP synthesis coupled proton transport (GO:0015986)2.39378337
122energy coupled proton transport, down electrochemical gradient (GO:0015985)2.39378337
123mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.39305808
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.38429893
125regulation of double-strand break repair via homologous recombination (GO:0010569)2.35164023
126regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.34013146
127meiotic nuclear division (GO:0007126)2.33262782
128rRNA modification (GO:0000154)2.31997194
129regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.31266944
130mitotic chromosome condensation (GO:0007076)2.30356707
131negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.29833396
132protein K11-linked ubiquitination (GO:0070979)2.29123762
133nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.28067573
134transcription-coupled nucleotide-excision repair (GO:0006283)2.27733889
135meiotic chromosome segregation (GO:0045132)2.27636327
136DNA replication-dependent nucleosome assembly (GO:0006335)2.27410013
137DNA replication-dependent nucleosome organization (GO:0034723)2.27410013
138synaptonemal complex assembly (GO:0007130)2.27398082
139mitochondrial respiratory chain complex assembly (GO:0033108)2.26860123
140synaptonemal complex organization (GO:0070193)2.26493293
141exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.24556211
142microtubule depolymerization (GO:0007019)2.24531689
143kinetochore assembly (GO:0051382)2.23439512
144positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.23069987
145pyrimidine nucleotide catabolic process (GO:0006244)2.22994487
146microtubule polymerization or depolymerization (GO:0031109)2.22887832
147synaptic vesicle exocytosis (GO:0016079)2.22479286
148positive regulation of meiotic cell cycle (GO:0051446)2.22014704
149protein localization to cilium (GO:0061512)2.22006909
150regulation of exit from mitosis (GO:0007096)2.21779122
151rRNA methylation (GO:0031167)2.21740210
152protein autoubiquitination (GO:0051865)2.19905365
153positive regulation of mitochondrial fission (GO:0090141)2.18141329
154spindle checkpoint (GO:0031577)2.18096920
155protein polyglutamylation (GO:0018095)2.17768320
156regulation of histone H3-K27 methylation (GO:0061085)2.14245743
157L-methionine salvage (GO:0071267)2.12936780
158L-methionine biosynthetic process (GO:0071265)2.12936780
159amino acid salvage (GO:0043102)2.12936780
160mitotic sister chromatid segregation (GO:0000070)2.12071820
161righting reflex (GO:0060013)2.11745839
162negative regulation of ligase activity (GO:0051352)2.11211945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.71426310
2EZH2_22144423_ChIP-Seq_EOC_Human3.65218191
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28677327
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.97475619
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.53272593
6* EST1_17652178_ChIP-ChIP_JURKAT_Human2.52228433
7E2F7_22180533_ChIP-Seq_HELA_Human2.45404718
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44026492
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.41500793
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32829751
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.28388580
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23831396
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.23722107
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20224122
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18909130
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17489239
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11469250
18GBX2_23144817_ChIP-Seq_PC3_Human2.09667668
19* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96820553
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95386395
21* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94889204
22PADI4_21655091_ChIP-ChIP_MCF-7_Human1.93436196
23TAF15_26573619_Chip-Seq_HEK293_Human1.91841436
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87425287
25FUS_26573619_Chip-Seq_HEK293_Human1.84232482
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77850505
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76581855
28VDR_23849224_ChIP-Seq_CD4+_Human1.74986442
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.74332424
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.71656940
31AR_21909140_ChIP-Seq_LNCAP_Human1.70524614
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.68737822
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57210581
34VDR_22108803_ChIP-Seq_LS180_Human1.54962821
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52547852
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51574019
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51573129
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49754088
39MYC_18940864_ChIP-ChIP_HL60_Human1.47451959
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.47335680
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46913347
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46814904
43DCP1A_22483619_ChIP-Seq_HELA_Human1.46581417
44FOXP3_21729870_ChIP-Seq_TREG_Human1.44107778
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43495913
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.43137633
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42461910
48RNF2_27304074_Chip-Seq_NSC_Mouse1.38892804
49ZNF274_21170338_ChIP-Seq_K562_Hela1.38323119
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35196334
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.32577985
52GABP_19822575_ChIP-Seq_HepG2_Human1.32175764
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31817489
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31706523
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31549321
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.29529743
57EWS_26573619_Chip-Seq_HEK293_Human1.27960570
58IGF1R_20145208_ChIP-Seq_DFB_Human1.27499438
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26348821
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25546485
61TTF2_22483619_ChIP-Seq_HELA_Human1.23230787
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20790211
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19103990
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18052640
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16399185
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15840899
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14119382
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14119382
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14119382
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13227012
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11800518
72ELK1_19687146_ChIP-ChIP_HELA_Human1.11199872
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.10422900
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09676207
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09664213
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09122289
77* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08474163
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08182289
79KDM5A_27292631_Chip-Seq_BREAST_Human1.08134114
80* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06036790
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04398962
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04183120
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03142287
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.02496310
85XRN2_22483619_ChIP-Seq_HELA_Human1.02192316
86REST_21632747_ChIP-Seq_MESCs_Mouse1.01937930
87GATA1_26923725_Chip-Seq_HPCs_Mouse1.01767778
88* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00284358
89SALL4_22934838_ChIP-ChIP_CD34+_Human0.99921207
90SMAD_19615063_ChIP-ChIP_OVARY_Human0.97655674
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97365274
92NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97150949
93P300_19829295_ChIP-Seq_ESCs_Human0.96978959
94ER_23166858_ChIP-Seq_MCF-7_Human0.96721016
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96628502
96* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96462093
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92980234
98CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92509574
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92162564
100IRF1_19129219_ChIP-ChIP_H3396_Human0.91661591
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90838779
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90132560
103* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89341400
104STAT3_18555785_Chip-Seq_ESCs_Mouse0.89056752
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88891243
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88046479
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87720350
108JUN_21703547_ChIP-Seq_K562_Human0.87289459
109CIITA_25753668_ChIP-Seq_RAJI_Human0.87105531
110POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.86324006
111* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85804820
112KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85762756
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85631715
114NFE2_27457419_Chip-Seq_LIVER_Mouse0.85350321
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.85014061
116POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84187445
117SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83544915
118SUZ12_18555785_Chip-Seq_ESCs_Mouse0.82810131
119* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82712509
120ELK1_22589737_ChIP-Seq_MCF10A_Human0.82215863
121REST_18959480_ChIP-ChIP_MESCs_Mouse0.81182175
122SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81042944
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80405305
124NMYC_18555785_Chip-Seq_ESCs_Mouse0.80311011
125TP63_19390658_ChIP-ChIP_HaCaT_Human0.80308252
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.80032642
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79376344
128EZH2_27294783_Chip-Seq_NPCs_Mouse0.78146307
129TP53_22573176_ChIP-Seq_HFKS_Human0.77741010
130NANOG_19829295_ChIP-Seq_ESCs_Human0.76955231
131SOX2_19829295_ChIP-Seq_ESCs_Human0.76955231
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75041030
133ZFX_18555785_ChIP-Seq_MESCs_Mouse0.72676906
134ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72332177
135SOX2_16153702_ChIP-ChIP_HESCs_Human0.71937505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.02367141
2MP0008877_abnormal_DNA_methylation3.59352321
3MP0001529_abnormal_vocalization2.67124001
4MP0004859_abnormal_synaptic_plasticity2.61452830
5MP0003718_maternal_effect2.45792540
6MP0001905_abnormal_dopamine_level2.39399996
7MP0010094_abnormal_chromosome_stability2.35790640
8MP0002102_abnormal_ear_morphology2.28277281
9MP0005395_other_phenotype2.28159247
10MP0003646_muscle_fatigue2.24890614
11MP0003890_abnormal_embryonic-extraembry2.00952005
12MP0004270_analgesia1.99312676
13MP0003693_abnormal_embryo_hatching1.97410443
14MP0003635_abnormal_synaptic_transmissio1.96131509
15MP0008057_abnormal_DNA_replication1.95415658
16MP0006276_abnormal_autonomic_nervous1.93480398
17MP0006292_abnormal_olfactory_placode1.90069922
18MP0001293_anophthalmia1.88427839
19MP0008260_abnormal_autophagy1.88261242
20MP0002736_abnormal_nociception_after1.86957892
21MP0005646_abnormal_pituitary_gland1.82619537
22MP0009046_muscle_twitch1.81508702
23MP0001968_abnormal_touch/_nociception1.78929083
24MP0003111_abnormal_nucleus_morphology1.75950312
25MP0002653_abnormal_ependyma_morphology1.75639233
26MP0002734_abnormal_mechanical_nocicepti1.73356884
27MP0001188_hyperpigmentation1.73313466
28MP0000372_irregular_coat_pigmentation1.73255001
29MP0005075_abnormal_melanosome_morpholog1.72124268
30MP0003077_abnormal_cell_cycle1.71163176
31MP0009745_abnormal_behavioral_response1.69339231
32MP0001929_abnormal_gametogenesis1.68085423
33MP0002064_seizures1.67676965
34MP0002210_abnormal_sex_determination1.64982107
35MP0004957_abnormal_blastocyst_morpholog1.64126589
36MP0002063_abnormal_learning/memory/cond1.63580699
37MP0003787_abnormal_imprinting1.63182706
38MP0002272_abnormal_nervous_system1.61968277
39MP0001730_embryonic_growth_arrest1.61422609
40MP0002572_abnormal_emotion/affect_behav1.57397761
41MP0008058_abnormal_DNA_repair1.56724203
42MP0005423_abnormal_somatic_nervous1.54377037
43MP0005410_abnormal_fertilization1.54029643
44MP0008932_abnormal_embryonic_tissue1.50700493
45MP0001984_abnormal_olfaction1.47935987
46MP0001485_abnormal_pinna_reflex1.45008173
47MP0006036_abnormal_mitochondrial_physio1.44696870
48MP0010307_abnormal_tumor_latency1.40839629
49MP0002234_abnormal_pharynx_morphology1.40413218
50MP0006035_abnormal_mitochondrial_morpho1.38869590
51MP0000653_abnormal_sex_gland1.37078288
52MP0001486_abnormal_startle_reflex1.37043969
53MP0003123_paternal_imprinting1.34634210
54MP0003698_abnormal_male_reproductive1.31531405
55MP0010030_abnormal_orbit_morphology1.30833567
56MP0009697_abnormal_copulation1.28104975
57MP0010386_abnormal_urinary_bladder1.27905743
58MP0001440_abnormal_grooming_behavior1.25547644
59MP0002067_abnormal_sensory_capabilities1.24449736
60MP0006072_abnormal_retinal_apoptosis1.24405768
61MP0003121_genomic_imprinting1.24046709
62MP0000015_abnormal_ear_pigmentation1.23415629
63MP0002735_abnormal_chemical_nociception1.23223192
64MP0001145_abnormal_male_reproductive1.22867983
65MP0002396_abnormal_hematopoietic_system1.20839881
66MP0001501_abnormal_sleep_pattern1.19640254
67MP0001970_abnormal_pain_threshold1.19557591
68MP0000778_abnormal_nervous_system1.18010231
69MP0004142_abnormal_muscle_tone1.15707214
70MP0000631_abnormal_neuroendocrine_gland1.10665851
71MP0004924_abnormal_behavior1.09918816
72MP0005386_behavior/neurological_phenoty1.09918816
73MP0002184_abnormal_innervation1.09529491
74MP0005310_abnormal_salivary_gland1.09002076
75MP0000313_abnormal_cell_death1.05758422
76MP0008789_abnormal_olfactory_epithelium1.05398986
77MP0002233_abnormal_nose_morphology1.05167732
78MP0001119_abnormal_female_reproductive1.03557302
79MP0005451_abnormal_body_composition1.03537991
80MP0005499_abnormal_olfactory_system1.02165281
81MP0005394_taste/olfaction_phenotype1.02165281
82MP0002733_abnormal_thermal_nociception1.02144478
83MP0003879_abnormal_hair_cell1.02089653
84MP0003186_abnormal_redox_activity1.01279901
85MP0002161_abnormal_fertility/fecundity0.98437118
86MP0005380_embryogenesis_phenotype0.97878086
87MP0001672_abnormal_embryogenesis/_devel0.97878086
88MP0002557_abnormal_social/conspecific_i0.97824192
89MP0003806_abnormal_nucleotide_metabolis0.97658874
90MP0002019_abnormal_tumor_incidence0.96832881
91MP0002882_abnormal_neuron_morphology0.95190554
92MP0003315_abnormal_perineum_morphology0.92903239
93MP0003136_yellow_coat_color0.92046870
94MP0001697_abnormal_embryo_size0.91169096
95MP0001986_abnormal_taste_sensitivity0.90585258
96MP0003567_abnormal_fetal_cardiomyocyte0.89708577
97MP0001963_abnormal_hearing_physiology0.88937323
98MP0002095_abnormal_skin_pigmentation0.88405572
99MP0008007_abnormal_cellular_replicative0.88270210
100MP0003195_calcinosis0.88133313
101MP0005645_abnormal_hypothalamus_physiol0.87438083
102MP0006082_CNS_inflammation0.87127405
103MP0004742_abnormal_vestibular_system0.86331898
104MP0005389_reproductive_system_phenotype0.85704977
105MP0000955_abnormal_spinal_cord0.85662185
106MP0003941_abnormal_skin_development0.83797219
107MP0002066_abnormal_motor_capabilities/c0.83301413
108MP0002751_abnormal_autonomic_nervous0.82209704
109MP0000427_abnormal_hair_cycle0.81891391
110MP0003786_premature_aging0.81672237
111MP0002152_abnormal_brain_morphology0.81274651
112MP0005174_abnormal_tail_pigmentation0.81192271
113MP0004145_abnormal_muscle_electrophysio0.81092137
114MP0000920_abnormal_myelination0.80763711
115MP0002638_abnormal_pupillary_reflex0.80239136
116MP0002163_abnormal_gland_morphology0.79632679
117MP0001764_abnormal_homeostasis0.79275908
118MP0002752_abnormal_somatic_nervous0.77964320
119MP0001502_abnormal_circadian_rhythm0.77183131
120MP0000703_abnormal_thymus_morphology0.77094609
121MP0003699_abnormal_female_reproductive0.76346320
122MP0003861_abnormal_nervous_system0.76327560
123MP0005671_abnormal_response_to0.76007259
124MP0000358_abnormal_cell_content/0.74813552
125MP0004811_abnormal_neuron_physiology0.74555951
126MP0002277_abnormal_respiratory_mucosa0.74436310
127MP0000026_abnormal_inner_ear0.72742946
128MP0000569_abnormal_digit_pigmentation0.72702188
129MP0002080_prenatal_lethality0.71673786
130MP0005409_darkened_coat_color0.71532992
131MP0003950_abnormal_plasma_membrane0.71354594
132MP0002085_abnormal_embryonic_tissue0.68815697
133MP0005379_endocrine/exocrine_gland_phen0.68436043
134MP0002084_abnormal_developmental_patter0.68224280
135MP0000350_abnormal_cell_proliferation0.68016236
136MP0002229_neurodegeneration0.67945958
137MP0003329_amyloid_beta_deposits0.66884901
138MP0002160_abnormal_reproductive_system0.66459409
139MP0000689_abnormal_spleen_morphology0.65589550
140MP0003632_abnormal_nervous_system0.65525111
141MP0002138_abnormal_hepatobiliary_system0.65038819
142MP0005551_abnormal_eye_electrophysiolog0.64601481
143MP0001324_abnormal_eye_pigmentation0.63958999
144MP0003938_abnormal_ear_development0.62621840
145MP0001346_abnormal_lacrimal_gland0.61539784
146MP0009333_abnormal_splenocyte_physiolog0.61397970
147MP0003119_abnormal_digestive_system0.61364130
148MP0003984_embryonic_growth_retardation0.60304734
149MP0002088_abnormal_embryonic_growth/wei0.59266150
150MP0002398_abnormal_bone_marrow0.58710058
151MP0003252_abnormal_bile_duct0.58372911
152MP0005408_hypopigmentation0.54742013
153MP0008995_early_reproductive_senescence0.54731303
154MP0002722_abnormal_immune_system0.53355924
155MP0003937_abnormal_limbs/digits/tail_de0.53096673
156MP0005253_abnormal_eye_physiology0.52482507
157MP0002938_white_spotting0.47627938

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)3.51911528
2Focal motor seizures (HP:0011153)3.47531318
3Cerebral hypomyelination (HP:0006808)3.36208745
4Acute necrotizing encephalopathy (HP:0006965)3.27100673
5Meckel diverticulum (HP:0002245)3.25763706
6Birth length less than 3rd percentile (HP:0003561)3.22767134
7Abnormality of the ileum (HP:0001549)3.16365609
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.14944152
9Colon cancer (HP:0003003)3.13470058
10Volvulus (HP:0002580)3.06163278
11Mitochondrial inheritance (HP:0001427)2.99608250
12Abnormal mitochondria in muscle tissue (HP:0008316)2.97237646
13Hepatocellular necrosis (HP:0001404)2.89275980
14Abnormal lung lobation (HP:0002101)2.82543762
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.80172513
16Abnormality of alanine metabolism (HP:0010916)2.80172513
17Hyperalaninemia (HP:0003348)2.80172513
18Abnormality of the labia minora (HP:0012880)2.78468977
19Progressive macrocephaly (HP:0004481)2.67838109
20Increased hepatocellular lipid droplets (HP:0006565)2.67738232
21Medial flaring of the eyebrow (HP:0010747)2.66726625
22Duodenal stenosis (HP:0100867)2.65446696
23Small intestinal stenosis (HP:0012848)2.65446696
24Cholecystitis (HP:0001082)2.64964297
25Abnormal gallbladder physiology (HP:0012438)2.64964297
26Methylmalonic acidemia (HP:0002912)2.64595555
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.64460085
28Absent/shortened dynein arms (HP:0200106)2.64460085
29Increased CSF lactate (HP:0002490)2.64051194
30Abnormality of glycolysis (HP:0004366)2.57767761
31Increased serum pyruvate (HP:0003542)2.57767761
32Abnormal respiratory motile cilium physiology (HP:0012261)2.52899398
33Gait imbalance (HP:0002141)2.49106830
34Atonic seizures (HP:0010819)2.49083529
35Chromsome breakage (HP:0040012)2.48852181
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47878790
37CNS hypomyelination (HP:0003429)2.46411128
38Oligodactyly (hands) (HP:0001180)2.41961494
39Type I transferrin isoform profile (HP:0003642)2.41204007
40Septo-optic dysplasia (HP:0100842)2.40762545
41Pancreatic fibrosis (HP:0100732)2.40603980
42Infertility (HP:0000789)2.40425349
43Abnormal ciliary motility (HP:0012262)2.40378992
44Gonadotropin excess (HP:0000837)2.37951971
45Congenital primary aphakia (HP:0007707)2.37058094
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.36059329
47Hyperglycinemia (HP:0002154)2.34333129
48Impulsivity (HP:0100710)2.34094528
49Abnormality of the duodenum (HP:0002246)2.33031537
50Breast hypoplasia (HP:0003187)2.31455290
51Abnormal hair whorl (HP:0010721)2.30982772
52Abnormality of the septum pellucidum (HP:0007375)2.30832349
53Abnormality of abdominal situs (HP:0011620)2.29431101
54Abdominal situs inversus (HP:0003363)2.29431101
55Nephroblastoma (Wilms tumor) (HP:0002667)2.27512580
56Premature ovarian failure (HP:0008209)2.27248298
57Oral leukoplakia (HP:0002745)2.25112204
58Nephrogenic diabetes insipidus (HP:0009806)2.25002745
59Sensory axonal neuropathy (HP:0003390)2.24651230
60Myelodysplasia (HP:0002863)2.23668187
61Abnormal respiratory epithelium morphology (HP:0012253)2.22107859
62Abnormal respiratory motile cilium morphology (HP:0005938)2.22107859
63Supernumerary spleens (HP:0009799)2.20608984
64Secondary amenorrhea (HP:0000869)2.20500092
65Clubbing of toes (HP:0100760)2.20462714
66Pancytopenia (HP:0001876)2.19012126
67Medulloblastoma (HP:0002885)2.18552169
68Unsteady gait (HP:0002317)2.18012268
69Hypoplasia of the fovea (HP:0007750)2.17831577
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.17831577
71Sloping forehead (HP:0000340)2.17120441
72Abnormality of the fovea (HP:0000493)2.16383301
73Abnormality of methionine metabolism (HP:0010901)2.15557712
74Acute encephalopathy (HP:0006846)2.15450590
75Methylmalonic aciduria (HP:0012120)2.15279436
76Embryonal renal neoplasm (HP:0011794)2.13823203
77Median cleft lip (HP:0000161)2.13419562
78Abnormal protein glycosylation (HP:0012346)2.12643817
79Abnormal glycosylation (HP:0012345)2.12643817
80Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12643817
81Abnormal protein N-linked glycosylation (HP:0012347)2.12643817
82Split foot (HP:0001839)2.12611182
83Epileptic encephalopathy (HP:0200134)2.12507150
84Combined immunodeficiency (HP:0005387)2.11166799
85Stenosis of the external auditory canal (HP:0000402)2.10925614
86Renal Fanconi syndrome (HP:0001994)2.10456506
87Delusions (HP:0000746)2.09806510
88Cleft eyelid (HP:0000625)2.07660623
89Reduced antithrombin III activity (HP:0001976)2.06151520
90Pancreatic cysts (HP:0001737)2.05095842
91Molar tooth sign on MRI (HP:0002419)2.04548929
92Abnormality of midbrain morphology (HP:0002418)2.04548929
93Abnormal spermatogenesis (HP:0008669)2.03332079
94Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02625595
95Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97864892
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97864892
97Genital tract atresia (HP:0001827)1.96676209
98Visual hallucinations (HP:0002367)1.96344199
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96067754
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.96067754
101True hermaphroditism (HP:0010459)1.96064826
102Myokymia (HP:0002411)1.94986258
103Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94056984
104Multiple enchondromatosis (HP:0005701)1.93283830
105Rhabdomyosarcoma (HP:0002859)1.93263810
106Short tibia (HP:0005736)1.92862303
107Postnatal microcephaly (HP:0005484)1.92801808
108Lipid accumulation in hepatocytes (HP:0006561)1.92703272
109Focal seizures (HP:0007359)1.92300732
110Aplastic anemia (HP:0001915)1.91796867
111Abnormal biliary tract physiology (HP:0012439)1.91748611
112Bile duct proliferation (HP:0001408)1.91748611
113Aplasia/Hypoplasia of the tongue (HP:0010295)1.91608029
114Azoospermia (HP:0000027)1.91096061
115Aplasia involving forearm bones (HP:0009822)1.91020270
116Absent forearm bone (HP:0003953)1.91020270
117Facial hemangioma (HP:0000329)1.90882188
118IgG deficiency (HP:0004315)1.90762816
119Vaginal atresia (HP:0000148)1.89988949
120Febrile seizures (HP:0002373)1.88000424
121Exertional dyspnea (HP:0002875)1.87831427
122Abnormality of the preputium (HP:0100587)1.87761959
123Cellular immunodeficiency (HP:0005374)1.87227630
124Progressive inability to walk (HP:0002505)1.86945008
125Increased serum lactate (HP:0002151)1.86775365
126Ectopic kidney (HP:0000086)1.85351222
127Poor coordination (HP:0002370)1.84839359
128Abnormality of the anterior horn cell (HP:0006802)1.84605615
129Degeneration of anterior horn cells (HP:0002398)1.84605615
130Limb hypertonia (HP:0002509)1.83790959
131Leukodystrophy (HP:0002415)1.83104207
132Neoplasm of the adrenal gland (HP:0100631)1.83050202
133Microvesicular hepatic steatosis (HP:0001414)1.82917697
134Pulmonary fibrosis (HP:0002206)1.82488520
135Patellar aplasia (HP:0006443)1.82464323
136Posterior subcapsular cataract (HP:0007787)1.81951819
137Papillary thyroid carcinoma (HP:0002895)1.81837358
138Duplicated collecting system (HP:0000081)1.81269629
139Rhinitis (HP:0012384)1.80755497
140Triphalangeal thumb (HP:0001199)1.79623901
141Nephronophthisis (HP:0000090)1.79292591
142Hepatic necrosis (HP:0002605)1.78343648
143Emotional lability (HP:0000712)1.76651640
144Absence seizures (HP:0002121)1.76322878
145Aplasia/Hypoplasia of the uvula (HP:0010293)1.75878885
146Severe combined immunodeficiency (HP:0004430)1.75790266
147Cerebral edema (HP:0002181)1.75055680
148Ependymoma (HP:0002888)1.74598739
149Abnormality of the renal collecting system (HP:0004742)1.73454801
150Absent thumb (HP:0009777)1.73222831
151Respiratory difficulties (HP:0002880)1.72448307
152Dialeptic seizures (HP:0011146)1.72343031
153Bifid tongue (HP:0010297)1.71665710
154Retinal dysplasia (HP:0007973)1.70204727
155Type 2 muscle fiber atrophy (HP:0003554)1.69788909
156Carpal bone hypoplasia (HP:0001498)1.69342971
157Horseshoe kidney (HP:0000085)1.68930829
158Limb dystonia (HP:0002451)1.68925134
159Male pseudohermaphroditism (HP:0000037)1.67832649
160Exercise intolerance (HP:0003546)1.67179643
161Respiratory failure (HP:0002878)1.66379733
162Increased intramyocellular lipid droplets (HP:0012240)1.65807991
163Aplasia/Hypoplasia of the patella (HP:0006498)1.65529892
164Absent septum pellucidum (HP:0001331)1.63416119
165Anencephaly (HP:0002323)1.62724387
166Absent radius (HP:0003974)1.62706850
167Optic disc pallor (HP:0000543)1.62148861
1683-Methylglutaconic aciduria (HP:0003535)1.60679057
169Aplasia/hypoplasia of the uterus (HP:0008684)1.60419810
170Abnormality of chromosome stability (HP:0003220)1.59896359

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.73135775
2BMPR23.56108153
3MAP3K123.14587186
4TRIM282.86783629
5NEK12.85359175
6BUB12.79470063
7VRK22.76525888
8ARAF2.64220365
9MAP3K92.60374789
10ZAK2.56206527
11NUAK12.31704591
12CDC72.22712522
13CDK192.19879082
14BRAF2.15897202
15MOS2.13515870
16MAP2K72.12520066
17STK162.02552664
18EIF2AK11.94487951
19MAP3K41.86588982
20VRK11.81261163
21TTK1.81258986
22CASK1.80036005
23MAP3K61.74711474
24PLK41.74051806
25NTRK31.72653879
26TLK11.69889794
27DYRK21.58855398
28BRSK21.57711747
29MUSK1.55107530
30TAF11.50763940
31EPHA41.47643984
32RAF11.44995898
33PDK21.43164361
34PNCK1.41428516
35MAP3K131.37594281
36DYRK31.30715735
37CSNK1G31.28934176
38OXSR11.28209500
39MAP4K21.27524205
40KSR21.27336357
41ACVR1B1.25641159
42WEE11.23000369
43MAPK131.21673117
44CDK81.19312880
45TESK21.18904584
46KSR11.18576510
47PLK21.17931833
48BRSK11.14096142
49BCR1.13370028
50BMPR1B1.13123048
51PLK31.10913402
52PBK1.09906058
53PLK11.08164096
54STK391.06123583
55RIPK41.03688902
56MARK11.02944312
57ERBB40.99966624
58EIF2AK20.99554336
59LATS20.98623910
60CSNK1G20.97852633
61TAOK30.97539894
62CSNK1G10.95551619
63SRPK10.91448638
64PRKCI0.89117857
65CDK70.88211044
66EIF2AK30.86437968
67CHEK20.86097450
68NME10.85350135
69OBSCN0.84200879
70NEK60.84108757
71MINK10.84002737
72KIT0.82264766
73CDK90.81203006
74MAPKAPK50.81117228
75STK240.80287772
76TNIK0.80195221
77ADRBK20.79817567
78ATM0.77477540
79NTRK20.77214257
80FGR0.75913626
81BCKDK0.75641668
82PAK60.75637378
83MELK0.74979653
84CSNK1A1L0.71219069
85ERBB30.71087150
86AURKA0.70436469
87TXK0.69900748
88STK40.66821131
89CAMK2A0.65353195
90KDR0.65294322
91LIMK10.62550970
92DAPK10.59203913
93PDK30.59042110
94PDK40.59042110
95CAMK2B0.58549989
96CCNB10.58406075
97FES0.57400864
98MKNK20.56847111
99TSSK60.56481177
100MKNK10.56389068
101DYRK1A0.56266215
102UHMK10.55790823
103STK38L0.55313540
104STK100.54065188
105CDK180.52796282
106CDK140.52678736
107ATR0.52097182
108PIM10.51227069
109NEK20.50470859
110MAP3K80.50073439
111STK30.49123060
112TNK20.48970419
113PASK0.48222923
114CLK10.47897798
115CDK150.47379960
116CSNK2A20.46196702
117CDK20.44240107
118CDK11A0.42674022
119CSNK2A10.41435170
120MAP2K40.39141930
121ROCK20.37818062
122MARK30.37566718
123AURKB0.37524341
124NME20.37272139
125CDK10.36365669
126CDK50.36240873
127SGK4940.35834619
128SGK2230.35834619
129MAP3K50.35025629
130CHEK10.33702159
131PAK10.33306703
132WNK30.33174326
133RPS6KA50.31845698
134IRAK20.31843813
135CSNK1E0.30446565
136RPS6KA40.30259428
137CSNK1D0.28554416

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.03269997
2Basal transcription factors_Homo sapiens_hsa030222.56586916
3Oxidative phosphorylation_Homo sapiens_hsa001902.45429914
4Proteasome_Homo sapiens_hsa030502.39042884
5Parkinsons disease_Homo sapiens_hsa050122.05459043
6Nicotine addiction_Homo sapiens_hsa050332.00057495
7Huntingtons disease_Homo sapiens_hsa050161.89107440
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84436656
9Homologous recombination_Homo sapiens_hsa034401.81240100
10Mismatch repair_Homo sapiens_hsa034301.81213047
11DNA replication_Homo sapiens_hsa030301.77261073
12Cell cycle_Homo sapiens_hsa041101.73908893
13Collecting duct acid secretion_Homo sapiens_hsa049661.72050415
14Oocyte meiosis_Homo sapiens_hsa041141.69496868
15Cysteine and methionine metabolism_Homo sapiens_hsa002701.68790084
16RNA degradation_Homo sapiens_hsa030181.66551882
17Synaptic vesicle cycle_Homo sapiens_hsa047211.65769978
18Spliceosome_Homo sapiens_hsa030401.63178299
19Fanconi anemia pathway_Homo sapiens_hsa034601.62381971
20Protein export_Homo sapiens_hsa030601.61064913
21RNA transport_Homo sapiens_hsa030131.57205926
22Nucleotide excision repair_Homo sapiens_hsa034201.56546617
23Alzheimers disease_Homo sapiens_hsa050101.55943551
24Non-homologous end-joining_Homo sapiens_hsa034501.53753534
25Propanoate metabolism_Homo sapiens_hsa006401.52375805
26Ribosome_Homo sapiens_hsa030101.45532278
27Fatty acid elongation_Homo sapiens_hsa000621.43992085
28Base excision repair_Homo sapiens_hsa034101.42289243
29Folate biosynthesis_Homo sapiens_hsa007901.41139707
30Pyrimidine metabolism_Homo sapiens_hsa002401.32415976
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29740467
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28717947
33One carbon pool by folate_Homo sapiens_hsa006701.26700097
34Vitamin B6 metabolism_Homo sapiens_hsa007501.26535237
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21478527
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21369076
37Primary immunodeficiency_Homo sapiens_hsa053401.20196448
38Olfactory transduction_Homo sapiens_hsa047401.19607990
39Ether lipid metabolism_Homo sapiens_hsa005651.17183037
40Serotonergic synapse_Homo sapiens_hsa047261.15993030
41Vibrio cholerae infection_Homo sapiens_hsa051101.15530379
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15526137
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14242390
44Glutamatergic synapse_Homo sapiens_hsa047241.13407554
45Amphetamine addiction_Homo sapiens_hsa050311.12514658
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12383749
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11813909
48Purine metabolism_Homo sapiens_hsa002301.06588594
49Long-term potentiation_Homo sapiens_hsa047201.06564712
50Morphine addiction_Homo sapiens_hsa050321.05477322
51Dopaminergic synapse_Homo sapiens_hsa047281.05412368
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05270185
53mRNA surveillance pathway_Homo sapiens_hsa030151.04053077
54Long-term depression_Homo sapiens_hsa047301.02115649
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01346108
56Rheumatoid arthritis_Homo sapiens_hsa053230.99227084
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97975767
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97785497
59Regulation of autophagy_Homo sapiens_hsa041400.94640566
60Type I diabetes mellitus_Homo sapiens_hsa049400.92596235
61Cardiac muscle contraction_Homo sapiens_hsa042600.91546408
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91332652
63Pyruvate metabolism_Homo sapiens_hsa006200.91265434
64Ovarian steroidogenesis_Homo sapiens_hsa049130.88494336
65Steroid biosynthesis_Homo sapiens_hsa001000.88226624
66Cocaine addiction_Homo sapiens_hsa050300.86833738
67Circadian entrainment_Homo sapiens_hsa047130.86809134
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85514780
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84831138
70Epstein-Barr virus infection_Homo sapiens_hsa051690.84186417
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83181146
72GABAergic synapse_Homo sapiens_hsa047270.82700297
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82131809
74Graft-versus-host disease_Homo sapiens_hsa053320.81153617
75Selenocompound metabolism_Homo sapiens_hsa004500.77970025
76Alcoholism_Homo sapiens_hsa050340.77308614
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76933779
78Phototransduction_Homo sapiens_hsa047440.71333326
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66110897
80Taste transduction_Homo sapiens_hsa047420.64965031
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64004836
82Caffeine metabolism_Homo sapiens_hsa002320.63356220
83Cholinergic synapse_Homo sapiens_hsa047250.62872415
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62306973
85GnRH signaling pathway_Homo sapiens_hsa049120.60933173
86Circadian rhythm_Homo sapiens_hsa047100.60682452
87Carbon metabolism_Homo sapiens_hsa012000.59830699
88Glutathione metabolism_Homo sapiens_hsa004800.56755060
89Sphingolipid metabolism_Homo sapiens_hsa006000.54502078
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54473621
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54194139
92Calcium signaling pathway_Homo sapiens_hsa040200.53445686
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52543316
94p53 signaling pathway_Homo sapiens_hsa041150.52023237
95Metabolic pathways_Homo sapiens_hsa011000.50137150
96Biosynthesis of amino acids_Homo sapiens_hsa012300.50106048
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49158010
98Oxytocin signaling pathway_Homo sapiens_hsa049210.48524712
99Phagosome_Homo sapiens_hsa041450.47009390
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46976073
101Herpes simplex infection_Homo sapiens_hsa051680.44561631
102Salmonella infection_Homo sapiens_hsa051320.43662433
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43170319
104Salivary secretion_Homo sapiens_hsa049700.42680415
105MAPK signaling pathway_Homo sapiens_hsa040100.42300842
106Peroxisome_Homo sapiens_hsa041460.40894729
107Ras signaling pathway_Homo sapiens_hsa040140.40138967
108Tuberculosis_Homo sapiens_hsa051520.39805402
109Allograft rejection_Homo sapiens_hsa053300.39771665
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.39692238
111Colorectal cancer_Homo sapiens_hsa052100.39208680
112Shigellosis_Homo sapiens_hsa051310.38867832
113Insulin secretion_Homo sapiens_hsa049110.38532339
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38117840
115Axon guidance_Homo sapiens_hsa043600.37326259
116cAMP signaling pathway_Homo sapiens_hsa040240.36693551
117Gap junction_Homo sapiens_hsa045400.36619847
118Renin secretion_Homo sapiens_hsa049240.36512937
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35584852
120Linoleic acid metabolism_Homo sapiens_hsa005910.35083605
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34485673
122Gastric acid secretion_Homo sapiens_hsa049710.34335846
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32341824
124ErbB signaling pathway_Homo sapiens_hsa040120.31826122
125Viral carcinogenesis_Homo sapiens_hsa052030.31329511
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31285629
127Vitamin digestion and absorption_Homo sapiens_hsa049770.29304018
128Butanoate metabolism_Homo sapiens_hsa006500.27661680
129Autoimmune thyroid disease_Homo sapiens_hsa053200.27291008
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24110428
131Measles_Homo sapiens_hsa051620.23963607
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23433235
133Systemic lupus erythematosus_Homo sapiens_hsa053220.22166696
134Antigen processing and presentation_Homo sapiens_hsa046120.19537281
135N-Glycan biosynthesis_Homo sapiens_hsa005100.18104914
136HTLV-I infection_Homo sapiens_hsa051660.13790252
137TGF-beta signaling pathway_Homo sapiens_hsa043500.13705519
138Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.12637327
139Hematopoietic cell lineage_Homo sapiens_hsa046400.12210381
140Legionellosis_Homo sapiens_hsa051340.11585514
141Pentose phosphate pathway_Homo sapiens_hsa000300.09020706
142Arginine and proline metabolism_Homo sapiens_hsa003300.05453060
143Asthma_Homo sapiens_hsa053100.04765861
144Thyroid cancer_Homo sapiens_hsa052160.03442434
145Tryptophan metabolism_Homo sapiens_hsa003800.03124345
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.02335657
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02190315
148Sulfur metabolism_Homo sapiens_hsa009200.01721326
149Fatty acid metabolism_Homo sapiens_hsa012120.01172131

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