RNF38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)5.35853581
2mitotic sister chromatid cohesion (GO:0007064)5.13937323
3piRNA metabolic process (GO:0034587)5.08797219
4acrosome reaction (GO:0007340)4.84427111
5regulation of sister chromatid cohesion (GO:0007063)4.53672757
6protein targeting to Golgi (GO:0000042)4.41770422
7spermatid nucleus differentiation (GO:0007289)4.35878154
8cytoplasmic mRNA processing body assembly (GO:0033962)4.35157419
9retrograde transport, vesicle recycling within Golgi (GO:0000301)4.31001164
10establishment of protein localization to Golgi (GO:0072600)4.27901662
11positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.19081364
12positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.19081364
13positive regulation of mitotic sister chromatid separation (GO:1901970)4.19081364
14female gamete generation (GO:0007292)4.14058180
15histone H2A monoubiquitination (GO:0035518)4.13525975
16monoubiquitinated protein deubiquitination (GO:0035520)4.11851622
17meiotic cell cycle (GO:0051321)4.07382197
18protein localization to chromosome, centromeric region (GO:0071459)3.99291092
19mitotic metaphase plate congression (GO:0007080)3.92855056
20meiotic chromosome segregation (GO:0045132)3.92601402
21mitotic sister chromatid segregation (GO:0000070)3.88429795
22nuclear pore complex assembly (GO:0051292)3.88161577
23interkinetic nuclear migration (GO:0022027)3.87662664
24oocyte development (GO:0048599)3.87608085
25male meiosis (GO:0007140)3.84694073
26RNA destabilization (GO:0050779)3.84477113
27histone H3-K9 demethylation (GO:0033169)3.83413209
28kinetochore organization (GO:0051383)3.82119267
29negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.80469559
30sperm motility (GO:0030317)3.79800900
31establishment of chromosome localization (GO:0051303)3.78546657
32sister chromatid segregation (GO:0000819)3.76318217
33DNA methylation (GO:0006306)3.70500735
34DNA alkylation (GO:0006305)3.70500735
35metaphase plate congression (GO:0051310)3.68686432
36attachment of spindle microtubules to kinetochore (GO:0008608)3.66988382
37DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.63524116
38DNA methylation involved in gamete generation (GO:0043046)3.61504751
39multicellular organism reproduction (GO:0032504)3.60456490
40regulation of female gonad development (GO:2000194)3.57464734
41negative regulation of histone methylation (GO:0031061)3.55858262
42gene silencing by RNA (GO:0031047)3.53702744
43DNA damage response, signal transduction resulting in transcription (GO:0042772)3.49112753
44sister chromatid cohesion (GO:0007062)3.47061108
45histone H3-K4 trimethylation (GO:0080182)3.46651041
46protein localization to chromosome (GO:0034502)3.45136312
47microtubule polymerization or depolymerization (GO:0031109)3.43791465
48protein localization to kinetochore (GO:0034501)3.36233207
49protein polyglutamylation (GO:0018095)3.33914806
50positive regulation of chromosome segregation (GO:0051984)3.33782161
51microtubule depolymerization (GO:0007019)3.30540039
52nucleus organization (GO:0006997)3.27860980
53DNA damage induced protein phosphorylation (GO:0006975)3.27170642
54oogenesis (GO:0048477)3.26266031
55histone H3-K36 demethylation (GO:0070544)3.25728086
56synaptonemal complex assembly (GO:0007130)3.25598436
57regulation of RNA export from nucleus (GO:0046831)3.21766494
58microtubule nucleation (GO:0007020)3.21565998
59histone H3-K4 methylation (GO:0051568)3.20187032
60centriole assembly (GO:0098534)3.19600024
61single strand break repair (GO:0000012)3.17982867
62kinetochore assembly (GO:0051382)3.17696187
63regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17676396
64pre-miRNA processing (GO:0031054)3.16159554
65chromosome condensation (GO:0030261)3.15820584
66positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.15445105
67peptidyl-lysine trimethylation (GO:0018023)3.14008690
68regulation of centriole replication (GO:0046599)3.10449967
69nuclear pore organization (GO:0006999)3.09832256
70phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.08828583
71cerebral cortex neuron differentiation (GO:0021895)3.05062872
72snRNA transcription (GO:0009301)3.04340215
73regulation of exit from mitosis (GO:0007096)3.04334843
74chromosome segregation (GO:0007059)3.03404000
75regulation of cell maturation (GO:1903429)3.03119134
76regulation of meiosis I (GO:0060631)3.02816804
77presynaptic membrane assembly (GO:0097105)3.02333606
78genitalia morphogenesis (GO:0035112)2.99977996
79DNA packaging (GO:0006323)2.99786011
80cytoskeleton-dependent cytokinesis (GO:0061640)2.98849904
81calcium ion-dependent exocytosis (GO:0017156)2.98352667
82regulation of histone H3-K9 methylation (GO:0051570)2.98182288
83histone H2A ubiquitination (GO:0033522)2.97310443
84regulation of meiosis (GO:0040020)2.96767857
85regulation of chromosome segregation (GO:0051983)2.96131136
86binding of sperm to zona pellucida (GO:0007339)2.94904496
87regulation of spindle organization (GO:0090224)2.93274720
88synaptonemal complex organization (GO:0070193)2.93253244
89regulation of acrosome reaction (GO:0060046)2.91436018
90spermatid development (GO:0007286)2.89805843
91vesicle transport along microtubule (GO:0047496)2.89482484
92regulation of transforming growth factor beta2 production (GO:0032909)2.88539212
93centriole replication (GO:0007099)2.88439866
94protein demethylation (GO:0006482)2.88041068
95protein dealkylation (GO:0008214)2.88041068
96positive regulation of gene expression, epigenetic (GO:0045815)2.87825723
97retinal cone cell development (GO:0046549)2.87107386
98regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86774308
99regulation of retinoic acid receptor signaling pathway (GO:0048385)2.86311453
100microtubule severing (GO:0051013)2.86261594
101mitotic nuclear envelope disassembly (GO:0007077)2.84350826
102gene silencing (GO:0016458)2.84323399
103neuron fate determination (GO:0048664)2.83799536
104DNA methylation or demethylation (GO:0044728)2.83320237
105negative regulation of circadian rhythm (GO:0042754)2.82854739
106regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80653424
107female gonad development (GO:0008585)2.79705427
108sperm-egg recognition (GO:0035036)2.79273279
109spermatogenesis (GO:0007283)2.78421849
110regulation of cell cycle G2/M phase transition (GO:1902749)2.78079590
111male gamete generation (GO:0048232)2.77303521
112pore complex assembly (GO:0046931)2.77091373
113sperm capacitation (GO:0048240)2.75545669
114spindle checkpoint (GO:0031577)2.74686334
115histone lysine demethylation (GO:0070076)2.74137667
116regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.74039444
117regulation of mitotic sister chromatid separation (GO:0010965)2.72762353
118regulation of mitotic sister chromatid segregation (GO:0033047)2.72762353
119regulation of sister chromatid segregation (GO:0033045)2.72762353
120membrane disassembly (GO:0030397)2.71117910
121nuclear envelope disassembly (GO:0051081)2.71117910
122gamete generation (GO:0007276)2.70832408
123pyrimidine nucleobase catabolic process (GO:0006208)2.70294163
124reproduction (GO:0000003)2.68744578
125DNA replication-independent nucleosome organization (GO:0034724)2.68713432
126DNA replication-independent nucleosome assembly (GO:0006336)2.68713432
127fertilization (GO:0009566)2.68183381
128histone H3-K9 methylation (GO:0051567)2.67883541
129regulation of DNA methylation (GO:0044030)2.67820103
130establishment of spindle localization (GO:0051293)2.67732499
131central nervous system projection neuron axonogenesis (GO:0021952)2.67625405
132regulation of chromatin silencing (GO:0031935)2.66178053
133negative regulation of translation, ncRNA-mediated (GO:0040033)2.66061203
134regulation of translation, ncRNA-mediated (GO:0045974)2.66061203
135negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.66061203
136chromatin assembly or disassembly (GO:0006333)2.64972577
137histone lysine methylation (GO:0034968)2.64839944
138protein localization to Golgi apparatus (GO:0034067)2.64766418
139nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.64228749
140corticosteroid receptor signaling pathway (GO:0031958)2.64001312
141negative regulation of histone modification (GO:0031057)2.62973695
142oocyte maturation (GO:0001556)2.61904663
143histone demethylation (GO:0016577)2.61667090
144histone exchange (GO:0043486)2.61498884
145Golgi to endosome transport (GO:0006895)2.60958456
146seminiferous tubule development (GO:0072520)2.60684668
147presynaptic membrane organization (GO:0097090)2.59657858
148glycine transport (GO:0015816)2.58619066
149histone H3-K9 modification (GO:0061647)2.58567386
150peptidyl-threonine dephosphorylation (GO:0035970)2.57988025
151regulation of synaptic vesicle exocytosis (GO:2000300)2.56542212
152negative regulation of cAMP-mediated signaling (GO:0043951)2.56080828
153fusion of sperm to egg plasma membrane (GO:0007342)2.55232076
154N-terminal protein amino acid acetylation (GO:0006474)2.54659154
155positive regulation of humoral immune response (GO:0002922)2.54243460
156neural tube formation (GO:0001841)2.54072417
157acrosome assembly (GO:0001675)2.51541324
158phosphatidylinositol dephosphorylation (GO:0046856)2.48754883
159germ cell development (GO:0007281)2.47720879
160negative regulation of chromatin modification (GO:1903309)2.47627047
161cilium or flagellum-dependent cell motility (GO:0001539)2.47606804
162regulation of Rab GTPase activity (GO:0032313)2.45281201
163positive regulation of Rab GTPase activity (GO:0032851)2.45281201
164positive regulation of histone H3-K4 methylation (GO:0051571)2.44204561
165negative regulation of inclusion body assembly (GO:0090084)2.43859221
166regulation of steroid hormone secretion (GO:2000831)2.42077245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.03381174
2E2F7_22180533_ChIP-Seq_HELA_Human5.54659100
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.85425290
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.14448377
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94929002
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.91196988
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78844182
8GBX2_23144817_ChIP-Seq_PC3_Human2.59520153
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.57736304
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.52029137
11EZH2_22144423_ChIP-Seq_EOC_Human2.33965173
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26883583
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22480733
14TAF15_26573619_Chip-Seq_HEK293_Human2.15541321
15AR_21909140_ChIP-Seq_LNCAP_Human2.11769268
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06720719
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05146271
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99705307
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90167547
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83877313
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75201074
22P300_19829295_ChIP-Seq_ESCs_Human1.72904831
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.72626660
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.69608989
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68606420
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68456934
27CBP_20019798_ChIP-Seq_JUKART_Human1.68456934
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68099944
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65687758
30* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65478217
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63300417
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62496029
33FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.61977723
34MYC_22102868_ChIP-Seq_BL_Human1.61636403
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61393820
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.60005560
37* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.57428594
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56156591
39* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56027069
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.54670534
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54187608
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54081795
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53135538
44* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52248511
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52165681
46FUS_26573619_Chip-Seq_HEK293_Human1.49552166
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49010420
48* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.48156862
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47824515
50IGF1R_20145208_ChIP-Seq_DFB_Human1.43781040
51TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.43562432
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.42903511
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39562550
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39562550
55* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38059103
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37718587
57* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37449010
58AR_25329375_ChIP-Seq_VCAP_Human1.37390840
59AR_21572438_ChIP-Seq_LNCaP_Human1.37387834
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36014219
61REST_21632747_ChIP-Seq_MESCs_Mouse1.35868603
62EWS_26573619_Chip-Seq_HEK293_Human1.34315101
63DROSHA_22980978_ChIP-Seq_HELA_Human1.34180313
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.32818714
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.32436965
66* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32339637
67* TCF7_22412390_ChIP-Seq_EML_Mouse1.31941748
68ZNF274_21170338_ChIP-Seq_K562_Hela1.31470186
69RUNX2_22187159_ChIP-Seq_PCA_Human1.31387243
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30384257
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.28618575
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27557390
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24899303
74* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22998223
75KDM2B_26808549_Chip-Seq_REH_Human1.22740295
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22410432
77TCF4_18268006_ChIP-ChIP_LS174T_Human1.21291631
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19999873
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19800519
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19616783
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19569667
82RNF2_27304074_Chip-Seq_NSC_Mouse1.18173088
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.16036432
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15081144
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15064381
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.14911740
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14314510
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13735259
89RUNX1_26923725_Chip-Seq_HPCs_Mouse1.12323863
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11851176
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11451798
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10955451
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10955451
94KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10955451
95KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10201666
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10129189
97ER_23166858_ChIP-Seq_MCF-7_Human1.09062670
98STAT3_23295773_ChIP-Seq_U87_Human1.08834011
99ISL1_27105846_Chip-Seq_CPCs_Mouse1.07787283
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06846956
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06829473
102SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05766019
103STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05496954
104FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04144329
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03013488
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.02634164
107ELK4_26923725_Chip-Seq_MESODERM_Mouse1.02396199
108P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02117323
109EZH2_27304074_Chip-Seq_ESCs_Mouse1.02029756
110SMAD3_21741376_ChIP-Seq_ESCs_Human1.00070654
111FLI1_21867929_ChIP-Seq_TH2_Mouse0.99577478
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.99046658
113RUNX_20019798_ChIP-Seq_JUKART_Human0.98586688
114STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98493167
115PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98299644
116TAL1_26923725_Chip-Seq_HPCs_Mouse0.96976005
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96732380
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.96049178
119ESR1_20079471_ChIP-ChIP_T-47D_Human0.95631767
120BRD4_25478319_ChIP-Seq_HGPS_Human0.95244787
121TBL1_22424771_ChIP-Seq_293T_Human0.94858567
122KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94501556
123AHR_22903824_ChIP-Seq_MCF-7_Human0.94478873
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.93864284
125YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93042196
126* AR_19668381_ChIP-Seq_PC3_Human0.92967990
127KDM2B_26808549_Chip-Seq_JURKAT_Human0.92483411
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92475274
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91239594
130PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90965064
131UTX_26944678_Chip-Seq_JUKART_Human0.90164643
132GF1B_26923725_Chip-Seq_HPCs_Mouse0.89843246
133TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88349193
134CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87402941
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86599285
136* TCF4_23295773_ChIP-Seq_U87_Human0.86122586
137MYB_26560356_Chip-Seq_TH2_Human0.85602723
138EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84641692
139GATA3_27048872_Chip-Seq_THYMUS_Human0.82820896
140CDX2_22108803_ChIP-Seq_LS180_Human0.81625059
141LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80636340
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.80541790
143MYB_26560356_Chip-Seq_TH1_Human0.79531504
144TP53_16413492_ChIP-PET_HCT116_Human0.79171664
145WDR5_24793694_ChIP-Seq_LNCAP_Human0.78646528
146EZH2_27294783_Chip-Seq_NPCs_Mouse0.78055638
147SMRT_27268052_Chip-Seq_Bcells_Human0.77718377
148GATA3_26560356_Chip-Seq_TH1_Human0.77209329
149IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.76801555
150GF1_26923725_Chip-Seq_HPCs_Mouse0.76261432
151SUZ12_27294783_Chip-Seq_NPCs_Mouse0.76103620
152* SMAD4_21799915_ChIP-Seq_A2780_Human0.75725615
153NFYA_21822215_ChIP-Seq_K562_Human0.75285963
154EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.74743044
155ZFP281_27345836_Chip-Seq_ESCs_Mouse0.74080402
156TBX3_20139965_ChIP-Seq_ESCs_Mouse0.74076656

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.58583085
2MP0008877_abnormal_DNA_methylation3.89719696
3MP0003121_genomic_imprinting3.16492282
4MP0003718_maternal_effect3.12714520
5MP0010094_abnormal_chromosome_stability3.03099871
6MP0000569_abnormal_digit_pigmentation2.93915071
7MP0005499_abnormal_olfactory_system2.87890765
8MP0005394_taste/olfaction_phenotype2.87890765
9MP0003693_abnormal_embryo_hatching2.87215041
10MP0003077_abnormal_cell_cycle2.70514262
11MP0003111_abnormal_nucleus_morphology2.58655137
12MP0004859_abnormal_synaptic_plasticity2.57532110
13MP0008789_abnormal_olfactory_epithelium2.41666949
14MP0008057_abnormal_DNA_replication2.36760281
15MP0003880_abnormal_central_pattern2.26972380
16MP0001929_abnormal_gametogenesis2.17774450
17MP0002653_abnormal_ependyma_morphology2.12050301
18MP0002822_catalepsy2.09965812
19MP0000778_abnormal_nervous_system2.03452130
20MP0002396_abnormal_hematopoietic_system1.99360295
21MP0004264_abnormal_extraembryonic_tissu1.99128898
22MP0004957_abnormal_blastocyst_morpholog1.93396969
23MP0002210_abnormal_sex_determination1.91493329
24MP0008007_abnormal_cellular_replicative1.88985653
25MP0001984_abnormal_olfaction1.88464497
26MP0002138_abnormal_hepatobiliary_system1.85706897
27MP0005076_abnormal_cell_differentiation1.81455138
28MP0003635_abnormal_synaptic_transmissio1.77983077
29MP0001119_abnormal_female_reproductive1.76183763
30MP0001486_abnormal_startle_reflex1.74973344
31MP0003699_abnormal_female_reproductive1.72093055
32MP0002102_abnormal_ear_morphology1.70344152
33MP0006276_abnormal_autonomic_nervous1.69679050
34MP0003878_abnormal_ear_physiology1.69159593
35MP0005377_hearing/vestibular/ear_phenot1.69159593
36MP0000350_abnormal_cell_proliferation1.67374860
37MP0000653_abnormal_sex_gland1.66466947
38MP0008058_abnormal_DNA_repair1.64784135
39MP0003122_maternal_imprinting1.62266327
40MP0004808_abnormal_hematopoietic_stem1.59941807
41MP0004270_analgesia1.59567684
42MP0005380_embryogenesis_phenotype1.56682070
43MP0001672_abnormal_embryogenesis/_devel1.56682070
44MP0003763_abnormal_thymus_physiology1.54927100
45MP0002735_abnormal_chemical_nociception1.53200158
46MP0006292_abnormal_olfactory_placode1.53070933
47MP0002085_abnormal_embryonic_tissue1.51806233
48MP0001730_embryonic_growth_arrest1.51413646
49MP0002084_abnormal_developmental_patter1.51365406
50MP0001188_hyperpigmentation1.51107375
51MP0003937_abnormal_limbs/digits/tail_de1.50581818
52MP0003183_abnormal_peptide_metabolism1.50059596
53MP0002063_abnormal_learning/memory/cond1.46935229
54MP0003698_abnormal_male_reproductive1.41258841
55MP0001697_abnormal_embryo_size1.39341234
56MP0005410_abnormal_fertilization1.39185491
57MP0003890_abnormal_embryonic-extraembry1.38758837
58MP0001145_abnormal_male_reproductive1.38645549
59MP0003984_embryonic_growth_retardation1.37144989
60MP0003879_abnormal_hair_cell1.36325709
61MP0004811_abnormal_neuron_physiology1.34905961
62MP0002088_abnormal_embryonic_growth/wei1.33312282
63MP0001849_ear_inflammation1.32821429
64MP0010307_abnormal_tumor_latency1.32644889
65MP0002161_abnormal_fertility/fecundity1.32158219
66MP0000631_abnormal_neuroendocrine_gland1.31621939
67MP0002272_abnormal_nervous_system1.31239352
68MP0003123_paternal_imprinting1.30394446
69MP0005395_other_phenotype1.30076042
70MP0005423_abnormal_somatic_nervous1.27284861
71MP0000733_abnormal_muscle_development1.21234046
72MP0001545_abnormal_hematopoietic_system1.18277059
73MP0005397_hematopoietic_system_phenotyp1.18277059
74MP0002572_abnormal_emotion/affect_behav1.18007367
75MP0002086_abnormal_extraembryonic_tissu1.17516002
76MP0002877_abnormal_melanocyte_morpholog1.17358846
77MP0000566_synostosis1.15108854
78MP0001915_intracranial_hemorrhage1.14311947
79MP0002009_preneoplasia1.14269025
80MP0002006_tumorigenesis1.14105015
81MP0003119_abnormal_digestive_system1.13975293
82MP0004185_abnormal_adipocyte_glucose1.12987841
83MP0003935_abnormal_craniofacial_develop1.10521701
84MP0003315_abnormal_perineum_morphology1.09778461
85MP0009278_abnormal_bone_marrow1.09447624
86MP0003646_muscle_fatigue1.09089651
87MP0002067_abnormal_sensory_capabilities1.08618897
88MP0000955_abnormal_spinal_cord1.08228098
89MP0010368_abnormal_lymphatic_system1.07856969
90MP0000579_abnormal_nail_morphology1.07295654
91MP0009745_abnormal_behavioral_response1.05302249
92MP0003755_abnormal_palate_morphology1.05178964
93MP0008932_abnormal_embryonic_tissue1.03404733
94MP0005451_abnormal_body_composition1.03003613
95MP0003861_abnormal_nervous_system1.02840304
96MP0004742_abnormal_vestibular_system1.00101559
97MP0001851_eye_inflammation0.99746513
98MP0002249_abnormal_larynx_morphology0.98940438
99MP0010352_gastrointestinal_tract_polyps0.97662695
100MP0002019_abnormal_tumor_incidence0.97618343
101MP0002928_abnormal_bile_duct0.97147119
102MP0008569_lethality_at_weaning0.96510351
103MP0000432_abnormal_head_morphology0.95569332
104MP0000703_abnormal_thymus_morphology0.95469015
105MP0002925_abnormal_cardiovascular_devel0.95321672
106MP0000490_abnormal_crypts_of0.95143651
107MP0005248_abnormal_Harderian_gland0.94486899
108MP0002152_abnormal_brain_morphology0.93385825
109MP0005187_abnormal_penis_morphology0.93066237
110MP0002882_abnormal_neuron_morphology0.92937500
111MP0002127_abnormal_cardiovascular_syste0.92170877
112MP0002557_abnormal_social/conspecific_i0.91415504
113MP0002398_abnormal_bone_marrow0.90272666
114MP0004924_abnormal_behavior0.89196685
115MP0005386_behavior/neurological_phenoty0.89196685
116MP0001963_abnormal_hearing_physiology0.89119464
117MP0005310_abnormal_salivary_gland0.88292989
118MP0001879_abnormal_lymphatic_vessel0.86602322
119MP0003385_abnormal_body_wall0.85079310
120MP0001346_abnormal_lacrimal_gland0.84610773
121MP0004142_abnormal_muscle_tone0.84493088
122MP0009115_abnormal_fat_cell0.84411386
123MP0010234_abnormal_vibrissa_follicle0.82941297
124MP0002080_prenatal_lethality0.82627068
125MP0000313_abnormal_cell_death0.82507579
126MP0002116_abnormal_craniofacial_bone0.82048337
127MP0002734_abnormal_mechanical_nocicepti0.81990334
128MP0003303_peritoneal_inflammation0.81764331
129MP0001177_atelectasis0.79137113
130MP0005253_abnormal_eye_physiology0.78692746
131MP0003091_abnormal_cell_migration0.78145561
132MP0002233_abnormal_nose_morphology0.77289544
133MP0009672_abnormal_birth_weight0.77114143
134MP0000383_abnormal_hair_follicle0.77074452
135MP0002282_abnormal_trachea_morphology0.76822646
136MP0009250_abnormal_appendicular_skeleto0.75701862
137MP0005647_abnormal_sex_gland0.74785361
138MP0005257_abnormal_intraocular_pressure0.74686411
139MP0005621_abnormal_cell_physiology0.74496827
140MP0001286_abnormal_eye_development0.74354800
141MP0009703_decreased_birth_body0.73959864
142MP0001502_abnormal_circadian_rhythm0.72961468
143MP0003115_abnormal_respiratory_system0.72827338
144MP0001919_abnormal_reproductive_system0.72763277
145MP0001986_abnormal_taste_sensitivity0.72390322
146MP0010678_abnormal_skin_adnexa0.72276014
147MP0003724_increased_susceptibility_to0.71443121
148MP0000049_abnormal_middle_ear0.70701827
149MP0004197_abnormal_fetal_growth/weight/0.70605146
150MP0005409_darkened_coat_color0.70601522
151MP0002109_abnormal_limb_morphology0.68987231
152MP0000026_abnormal_inner_ear0.68957462
153MP0002064_seizures0.68789871
154MP0001968_abnormal_touch/_nociception0.67879441
155MP0008995_early_reproductive_senescence0.66638847
156MP0001293_anophthalmia0.66272765
157MP0000465_gastrointestinal_hemorrhage0.66151164
158MP0005551_abnormal_eye_electrophysiolog0.65953175
159MP0002081_perinatal_lethality0.65788033
160MP0001485_abnormal_pinna_reflex0.65599137
161MP0003300_gastrointestinal_ulcer0.65585624
162MP0002751_abnormal_autonomic_nervous0.65307081
163MP0001501_abnormal_sleep_pattern0.63685795
164MP0002184_abnormal_innervation0.63381937

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)5.07394533
2Cortical dysplasia (HP:0002539)4.50416620
3Tubulointerstitial nephritis (HP:0001970)4.46654751
4Abnormality of the fingertips (HP:0001211)4.41174342
5Chromsome breakage (HP:0040012)3.66203260
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.58363263
7Acute myeloid leukemia (HP:0004808)3.49214782
8Chronic hepatic failure (HP:0100626)3.20521602
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20081394
10Facial hemangioma (HP:0000329)3.13016673
11Lip pit (HP:0100267)3.08232049
12Volvulus (HP:0002580)3.06536433
13Male infertility (HP:0003251)3.03101610
14Progressive cerebellar ataxia (HP:0002073)2.86399319
15Thyroid carcinoma (HP:0002890)2.83411578
16Osteomalacia (HP:0002749)2.83284665
17Cone-rod dystrophy (HP:0000548)2.81109620
18Thickened helices (HP:0000391)2.79042345
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.78662302
20Short 4th metacarpal (HP:0010044)2.78662302
21Heterotopia (HP:0002282)2.74462880
22Abnormality of chromosome segregation (HP:0002916)2.65298288
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.64677024
24Ectopic kidney (HP:0000086)2.59990196
25Midline defect of the nose (HP:0004122)2.58421430
26Patellar aplasia (HP:0006443)2.57394676
27Shawl scrotum (HP:0000049)2.50263339
28Supernumerary spleens (HP:0009799)2.49630188
29Impulsivity (HP:0100710)2.44050731
30Abnormality of the labia minora (HP:0012880)2.43243541
31Long eyelashes (HP:0000527)2.41058842
32Abnormality of chromosome stability (HP:0003220)2.37885820
33Aplasia/Hypoplasia of the patella (HP:0006498)2.33808104
34Menstrual irregularities (HP:0000858)2.33204863
35Sandal gap (HP:0001852)2.29704561
36Anterior segment dysgenesis (HP:0007700)2.29564187
37Abnormality of the intervertebral disk (HP:0005108)2.28019754
38Trigonocephaly (HP:0000243)2.23457964
39Hyperkalemia (HP:0002153)2.22490919
40Transitional cell carcinoma of the bladder (HP:0006740)2.21469766
41Drooling (HP:0002307)2.20925906
42Excessive salivation (HP:0003781)2.19861611
43Intellectual disability, moderate (HP:0002342)2.18696845
44Truncal obesity (HP:0001956)2.18634743
45Birth length less than 3rd percentile (HP:0003561)2.15181472
46Medulloblastoma (HP:0002885)2.13341229
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.13042719
48Amyotrophic lateral sclerosis (HP:0007354)2.12590847
49Neoplasm of the oral cavity (HP:0100649)2.12542094
50Abdominal situs inversus (HP:0003363)2.10990355
51Abnormality of abdominal situs (HP:0011620)2.10990355
52Capillary hemangiomas (HP:0005306)2.09209529
53Tubulointerstitial abnormality (HP:0001969)2.08422119
54Sparse lateral eyebrow (HP:0005338)2.08373339
55Optic nerve hypoplasia (HP:0000609)2.08343883
56Febrile seizures (HP:0002373)2.08339551
57Papilledema (HP:0001085)2.07427380
58Deep philtrum (HP:0002002)2.07094474
59Absent speech (HP:0001344)2.07092032
60Disinhibition (HP:0000734)2.06599393
61Prostate neoplasm (HP:0100787)2.06325941
62Narrow palate (HP:0000189)2.06137372
63Prominent nose (HP:0000448)2.05699444
64Postural instability (HP:0002172)2.05080189
65Chronic bronchitis (HP:0004469)2.03538535
66Neoplasm of the heart (HP:0100544)2.03441539
67Gonadotropin excess (HP:0000837)2.03031402
68Widely spaced teeth (HP:0000687)2.01465818
69Bladder neoplasm (HP:0009725)2.00005938
70Bladder carcinoma (HP:0002862)2.00005938
71Genetic anticipation (HP:0003743)1.99845378
72Oligodactyly (hands) (HP:0001180)1.97786636
73Myokymia (HP:0002411)1.97495911
74Increased nuchal translucency (HP:0010880)1.97112900
75Hypophosphatemic rickets (HP:0004912)1.95510468
76Oligodactyly (HP:0012165)1.94595881
77Abnormality of the 4th metacarpal (HP:0010012)1.94089240
78Abnormal respiratory motile cilium physiology (HP:0012261)1.93908667
79Abnormality of the phalanges of the hallux (HP:0010057)1.92304037
80Abnormality of the carotid arteries (HP:0005344)1.92151155
81Slow-growing hair (HP:0002217)1.91326414
82Abnormality of hair growth rate (HP:0011363)1.91326414
83Leiomyosarcoma (HP:0100243)1.90248053
84Uterine leiomyosarcoma (HP:0002891)1.90248053
85Obsessive-compulsive behavior (HP:0000722)1.89323190
86Abnormality of the septum pellucidum (HP:0007375)1.88653371
87Abnormal ciliary motility (HP:0012262)1.87977013
88Meckel diverticulum (HP:0002245)1.86200557
89Growth hormone deficiency (HP:0000824)1.85515501
90Abnormal hair whorl (HP:0010721)1.83582261
91Clubbing of toes (HP:0100760)1.82760005
92Bony spicule pigmentary retinopathy (HP:0007737)1.82654827
93Fair hair (HP:0002286)1.82284549
94Abnormality of the distal phalanx of the thumb (HP:0009617)1.81771016
95Supernumerary ribs (HP:0005815)1.81417654
96Infertility (HP:0000789)1.80779689
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.79041719
98Broad thumb (HP:0011304)1.77854620
99Neoplasm of the tracheobronchial system (HP:0100552)1.77573869
100Aplasia/Hypoplasia of the earlobes (HP:0009906)1.77034797
101Septo-optic dysplasia (HP:0100842)1.75348955
102Aqueductal stenosis (HP:0002410)1.75092220
103Insulin-resistant diabetes mellitus (HP:0000831)1.74094997
104Sparse scalp hair (HP:0002209)1.73697827
105Duodenal stenosis (HP:0100867)1.73655294
106Small intestinal stenosis (HP:0012848)1.73655294
107Abnormality of the preputium (HP:0100587)1.73460055
108Impaired vibration sensation in the lower limbs (HP:0002166)1.73360332
109Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73224473
110Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.73150887
111Sloping forehead (HP:0000340)1.72358015
112Absent/shortened dynein arms (HP:0200106)1.72258089
113Dynein arm defect of respiratory motile cilia (HP:0012255)1.72258089
114Abnormality of the ileum (HP:0001549)1.72021503
115Portal hypertension (HP:0001409)1.70533598
116Thyroiditis (HP:0100646)1.70323622
117Cystic hygroma (HP:0000476)1.69881210
118Cutis marmorata (HP:0000965)1.69851369
119Myelodysplasia (HP:0002863)1.68712891
120Abnormality of incisor morphology (HP:0011063)1.68382861
121Lissencephaly (HP:0001339)1.68336820
122Deep palmar crease (HP:0006191)1.67894191
123Deeply set eye (HP:0000490)1.67689292
124Optic neuritis (HP:0100653)1.67333061
125Retrobulbar optic neuritis (HP:0100654)1.67333061
126Abnormality of the nasal septum (HP:0000419)1.67086628
127Arterial tortuosity (HP:0005116)1.66846422
128Embryonal renal neoplasm (HP:0011794)1.66367851
129Median cleft lip (HP:0000161)1.66300975
130Peripheral hypomyelination (HP:0007182)1.66049346
131Apathy (HP:0000741)1.65000378
132Rhabdomyosarcoma (HP:0002859)1.64492004
133Acute lymphatic leukemia (HP:0006721)1.62783965
134Patellar dislocation (HP:0002999)1.62235592
135Overlapping toe (HP:0001845)1.61921830
136Inappropriate behavior (HP:0000719)1.61656283
137Broad alveolar ridges (HP:0000187)1.61367080
138Abnormality of macular pigmentation (HP:0008002)1.60911848
139Rhinitis (HP:0012384)1.60220641
140Highly arched eyebrow (HP:0002553)1.60055879
141Flat capital femoral epiphysis (HP:0003370)1.59774416
142Depressed nasal tip (HP:0000437)1.59511048
143Molar tooth sign on MRI (HP:0002419)1.59434611
144Abnormality of midbrain morphology (HP:0002418)1.59434611
145Atonic seizures (HP:0010819)1.59130798
146Subacute progressive viral hepatitis (HP:0006572)1.59017988
147Neoplasm of striated muscle (HP:0009728)1.58517090
148Gastrointestinal carcinoma (HP:0002672)1.57146709
149Malignant gastrointestinal tract tumors (HP:0006749)1.57146709
150Omphalocele (HP:0001539)1.57070647
151Hyperventilation (HP:0002883)1.57029644
152Stomach cancer (HP:0012126)1.55903002
153Aplasia/Hypoplasia of the brainstem (HP:0007362)1.55688853
154Hypoplasia of the brainstem (HP:0002365)1.55688853
155Nephroblastoma (Wilms tumor) (HP:0002667)1.55194061
156Spondylolisthesis (HP:0003302)1.54998356
157Cupped ear (HP:0000378)1.54393842
158Abnormality of the aortic arch (HP:0012303)1.54393456
159Broad palm (HP:0001169)1.53175108
160Hepatoblastoma (HP:0002884)1.51862420
161Enlarged penis (HP:0000040)1.51507542
162Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.51499461
163Absent septum pellucidum (HP:0001331)1.51219801
164Absent frontal sinuses (HP:0002688)1.50978837
165Skull defect (HP:0001362)1.50974055
166Primary amenorrhea (HP:0000786)1.49398181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.52809989
2TAOK34.02268917
3CDK123.91400813
4CDC73.68532982
5MAP3K63.53523631
6MARK13.36078880
7PLK42.99596413
8LATS22.54584002
9EEF2K2.49136335
10NEK22.40815458
11PRKD32.39265865
12TRIM282.39099856
13CASK2.35500625
14STK32.27390438
15TAOK12.26271550
16CHEK22.24593903
17TTK2.20358388
18STK102.15172431
19STK38L2.02637053
20CDK91.85688753
21DMPK1.79767520
22MAP4K21.75521970
23NEK61.69502845
24TNIK1.66257488
25TYRO31.60328009
26MELK1.55108665
27ARAF1.52172753
28CDK81.46534337
29MAP3K41.43722092
30ERBB41.41820877
31WNK11.40771398
32NTRK31.39527181
33SGK4941.37451447
34BCR1.32865440
35MAP3K91.32356776
36PNCK1.31233454
37CHEK11.18227976
38BRAF1.14650763
39RPS6KA41.13607888
40CDK61.12805139
41CDK31.12795094
42PLK21.12722848
43EPHA41.12228204
44EPHA31.11874098
45AKT31.11846689
46NTRK21.08635448
47PIK3CG1.08586205
48MAP3K131.08565604
49CDK191.07097211
50NUAK11.05611144
51BRD41.04246211
52CAMK1G1.03673413
53ATM1.02553506
54BRSK21.01949282
55STK381.00288316
56CDK40.94153680
57PLK10.91803551
58RET0.90774929
59DYRK1B0.90543246
60SGK20.90305880
61YES10.89726013
62UHMK10.88549762
63CAMK1D0.87756778
64MAPK130.87457415
65AURKB0.85841428
66MAP2K70.85510347
67NLK0.84513710
68RIPK40.82994080
69ATR0.82113082
70PRKD20.79470530
71PRKAA10.78997619
72TAF10.78632204
73ACVR1B0.77505979
74CDK70.76747904
75CDK50.76711041
76KSR20.76561874
77CSNK1G10.75520713
78SGK30.75274790
79KSR10.74563026
80FGFR20.74235147
81FGFR30.73995828
82MTOR0.73938669
83WNK30.73900017
84ICK0.73846617
85STK240.73826627
86MAP3K80.72772026
87CAMK40.70066633
88PDK10.69870478
89CDK20.67849295
90MAP3K100.66418937
91MARK20.65595852
92PRKAA20.64663515
93RAF10.63457886
94CDK10.62643202
95STK40.61946229
96CHUK0.61776516
97INSRR0.59258553
98DYRK1A0.57461851
99DYRK20.54914908
100PDGFRB0.54739946
101SIK20.54333538
102MAP4K10.54184730
103PLK30.53652965
104RPS6KB20.53115939
105MAP3K50.51814460
106CSNK1G20.50932465
107MAP2K40.50350257
108BRSK10.48832274
109MAPK100.48812663
110PRKG10.48494735
111MAPK140.48409812
112CSNK1A1L0.46884359
113MINK10.46518669
114SGK10.45598191
115PAK60.44938908
116MAP3K70.44585245
117MOS0.43277147
118JAK30.43204733
119ABL10.42570340
120FES0.41932423
121MAP3K140.41899831
122AKT10.41767611
123SRPK10.41750649
124PINK10.41447335
125GSK3B0.41027409
126CSNK1D0.39299590
127TRIB30.38022881
128PRPF4B0.37869548
129VRK10.36637566
130CAMK10.36374479
131PRKCZ0.36259338
132PDK30.34713972
133PDK40.34713972
134DYRK30.34444567
135MAPKAPK30.34418512
136PIM10.34044488
137TEC0.33709061
138BMPR1B0.33109998
139HCK0.32562955
140MARK30.32475493
141MUSK0.32443496
142SIK30.32368176
143MAPK10.30252742
144MAPK80.29618956
145TXK0.25778633
146STK110.25512257
147HIPK20.25288842
148SGK2230.24578314

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.59157398
2Dorso-ventral axis formation_Homo sapiens_hsa043202.22946447
3Basal transcription factors_Homo sapiens_hsa030222.06951091
4Pancreatic cancer_Homo sapiens_hsa052121.93114595
5Nicotine addiction_Homo sapiens_hsa050331.88905780
6Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.81007245
7Colorectal cancer_Homo sapiens_hsa052101.74994058
8RNA degradation_Homo sapiens_hsa030181.71032235
9MicroRNAs in cancer_Homo sapiens_hsa052061.69844839
10Fanconi anemia pathway_Homo sapiens_hsa034601.63926536
11p53 signaling pathway_Homo sapiens_hsa041151.62100706
12Long-term potentiation_Homo sapiens_hsa047201.58974533
13Non-homologous end-joining_Homo sapiens_hsa034501.57113375
14Long-term depression_Homo sapiens_hsa047301.56544529
15Oocyte meiosis_Homo sapiens_hsa041141.49740664
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47903496
17Olfactory transduction_Homo sapiens_hsa047401.47596232
18Endometrial cancer_Homo sapiens_hsa052131.47159193
19Adherens junction_Homo sapiens_hsa045201.45000853
20Gap junction_Homo sapiens_hsa045401.44544144
21mTOR signaling pathway_Homo sapiens_hsa041501.43282906
22Chronic myeloid leukemia_Homo sapiens_hsa052201.42266838
23TGF-beta signaling pathway_Homo sapiens_hsa043501.38887847
24Circadian rhythm_Homo sapiens_hsa047101.36268990
25mRNA surveillance pathway_Homo sapiens_hsa030151.32277922
26Morphine addiction_Homo sapiens_hsa050321.30894199
27RNA transport_Homo sapiens_hsa030131.29818546
28Circadian entrainment_Homo sapiens_hsa047131.29704943
29GABAergic synapse_Homo sapiens_hsa047271.26829027
30Ovarian steroidogenesis_Homo sapiens_hsa049131.26195795
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25818716
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25381044
33Non-small cell lung cancer_Homo sapiens_hsa052231.22121142
34Glutamatergic synapse_Homo sapiens_hsa047241.21353844
35Small cell lung cancer_Homo sapiens_hsa052221.21105433
36Homologous recombination_Homo sapiens_hsa034401.20555128
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20482046
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20212099
39Prolactin signaling pathway_Homo sapiens_hsa049171.19799315
40Renal cell carcinoma_Homo sapiens_hsa052111.19699648
41FoxO signaling pathway_Homo sapiens_hsa040681.18719254
42Herpes simplex infection_Homo sapiens_hsa051681.16941823
43Taste transduction_Homo sapiens_hsa047421.15527373
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14406564
45Amphetamine addiction_Homo sapiens_hsa050311.13742188
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10542132
47HTLV-I infection_Homo sapiens_hsa051661.09306304
48Choline metabolism in cancer_Homo sapiens_hsa052311.08040208
49Notch signaling pathway_Homo sapiens_hsa043301.05550989
50Fatty acid biosynthesis_Homo sapiens_hsa000611.04493904
51Hippo signaling pathway_Homo sapiens_hsa043901.03302996
52Hepatitis B_Homo sapiens_hsa051611.02972723
53Prostate cancer_Homo sapiens_hsa052151.02276381
54Thyroid cancer_Homo sapiens_hsa052161.01233709
55Dopaminergic synapse_Homo sapiens_hsa047281.00908786
56T cell receptor signaling pathway_Homo sapiens_hsa046601.00363307
57VEGF signaling pathway_Homo sapiens_hsa043701.00341795
58Regulation of autophagy_Homo sapiens_hsa041400.97986873
59Lysine degradation_Homo sapiens_hsa003100.97868268
60Cholinergic synapse_Homo sapiens_hsa047250.97512060
61Basal cell carcinoma_Homo sapiens_hsa052170.97387567
62B cell receptor signaling pathway_Homo sapiens_hsa046620.94318577
63Wnt signaling pathway_Homo sapiens_hsa043100.92336266
64Base excision repair_Homo sapiens_hsa034100.91913704
65Viral myocarditis_Homo sapiens_hsa054160.90279514
66Cocaine addiction_Homo sapiens_hsa050300.90243386
67Toxoplasmosis_Homo sapiens_hsa051450.89204345
68Glioma_Homo sapiens_hsa052140.88984306
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.87604562
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86498327
71Oxytocin signaling pathway_Homo sapiens_hsa049210.85892587
72Primary immunodeficiency_Homo sapiens_hsa053400.84529677
73TNF signaling pathway_Homo sapiens_hsa046680.83589475
74Shigellosis_Homo sapiens_hsa051310.82367340
75Serotonergic synapse_Homo sapiens_hsa047260.82232835
76Renin secretion_Homo sapiens_hsa049240.82227807
77ErbB signaling pathway_Homo sapiens_hsa040120.82109820
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81941666
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81231253
80Viral carcinogenesis_Homo sapiens_hsa052030.80680286
81Osteoclast differentiation_Homo sapiens_hsa043800.80596129
82Pathways in cancer_Homo sapiens_hsa052000.80267463
83Synaptic vesicle cycle_Homo sapiens_hsa047210.80084362
84GnRH signaling pathway_Homo sapiens_hsa049120.79824280
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79513147
86Acute myeloid leukemia_Homo sapiens_hsa052210.79405469
87MAPK signaling pathway_Homo sapiens_hsa040100.79093183
88Hedgehog signaling pathway_Homo sapiens_hsa043400.78539835
89Platelet activation_Homo sapiens_hsa046110.77736928
90Chemokine signaling pathway_Homo sapiens_hsa040620.75355978
91Measles_Homo sapiens_hsa051620.75146205
92Influenza A_Homo sapiens_hsa051640.74767531
93Estrogen signaling pathway_Homo sapiens_hsa049150.74034904
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.73974881
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73511157
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72870779
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71389298
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70717982
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69752213
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68937540
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.68486834
102Proteoglycans in cancer_Homo sapiens_hsa052050.68175530
103Ras signaling pathway_Homo sapiens_hsa040140.67710118
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66441686
105Melanogenesis_Homo sapiens_hsa049160.66079040
106Epstein-Barr virus infection_Homo sapiens_hsa051690.65306583
107Hematopoietic cell lineage_Homo sapiens_hsa046400.64413693
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63877567
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.63764740
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.62271549
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61973374
112Insulin signaling pathway_Homo sapiens_hsa049100.61788792
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61661385
114Type II diabetes mellitus_Homo sapiens_hsa049300.61110206
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60435697
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.60382546
117Axon guidance_Homo sapiens_hsa043600.60013614
118cAMP signaling pathway_Homo sapiens_hsa040240.59935318
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58878481
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58857582
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58754956
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58658119
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.58483352
124Phototransduction_Homo sapiens_hsa047440.58365444
125Inositol phosphate metabolism_Homo sapiens_hsa005620.58207082
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58152466
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57660339
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56959120
129Leishmaniasis_Homo sapiens_hsa051400.56923637
130Endocytosis_Homo sapiens_hsa041440.56690463
131Focal adhesion_Homo sapiens_hsa045100.56316804
132Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55250876
133Rap1 signaling pathway_Homo sapiens_hsa040150.55000673
134Apoptosis_Homo sapiens_hsa042100.53808486
135ABC transporters_Homo sapiens_hsa020100.52344779

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