RNF39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene lies within the major histocompatibility complex class I region on chromosome 6. Studies of a similar rat protein suggest that this gene encodes a protein that plays a role in an early phase of synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.62443832
2keratinization (GO:0031424)9.52810011
3establishment of skin barrier (GO:0061436)8.48196616
4regulation of water loss via skin (GO:0033561)7.73352637
5hemidesmosome assembly (GO:0031581)6.81794366
6lipoxygenase pathway (GO:0019372)6.42380177
7intermediate filament organization (GO:0045109)6.07530185
8positive regulation of cellular amide metabolic process (GO:0034250)5.82179312
9bundle of His cell to Purkinje myocyte communication (GO:0086069)5.77084953
10keratinocyte differentiation (GO:0030216)5.36199342
11multicellular organismal water homeostasis (GO:0050891)5.31310073
12peptide cross-linking (GO:0018149)5.26792255
13regulation of transforming growth factor beta1 production (GO:0032908)5.22021579
14detection of bacterium (GO:0016045)4.91673358
15linoleic acid metabolic process (GO:0043651)4.83261766
16positive regulation of p38MAPK cascade (GO:1900745)4.79486149
17water homeostasis (GO:0030104)4.79215989
18regulation of cell proliferation involved in kidney development (GO:1901722)4.72195977
19positive regulation of glomerulus development (GO:0090193)4.57685264
20epidermis development (GO:0008544)4.50192172
21negative regulation of interleukin-17 production (GO:0032700)4.46825070
22detection of other organism (GO:0098543)4.43967072
23negative regulation of interferon-gamma production (GO:0032689)4.43500543
24phosphatidylserine acyl-chain remodeling (GO:0036150)4.41475514
25L-phenylalanine catabolic process (GO:0006559)4.34025486
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.34025486
27regulation of natural killer cell differentiation (GO:0032823)4.27902564
28L-phenylalanine metabolic process (GO:0006558)4.21469505
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.21469505
30positive regulation of epidermis development (GO:0045684)4.21089905
31fatty acid elongation (GO:0030497)4.17041168
32phospholipid efflux (GO:0033700)4.13909234
33surfactant homeostasis (GO:0043129)4.07506184
34epidermal cell differentiation (GO:0009913)4.02489881
35defense response to Gram-negative bacterium (GO:0050829)4.02384638
36positive regulation of epidermal cell differentiation (GO:0045606)4.01324613
37positive regulation of keratinocyte differentiation (GO:0045618)4.00757324
38fibrinolysis (GO:0042730)3.97523649
39cellular glucuronidation (GO:0052695)3.96205453
40defense response to fungus (GO:0050832)3.93896303
41keratinocyte proliferation (GO:0043616)3.93643994
42negative regulation of lipase activity (GO:0060192)3.90692801
43chemical homeostasis within a tissue (GO:0048875)3.84134757
44antimicrobial humoral response (GO:0019730)3.82758650
45regulation of p38MAPK cascade (GO:1900744)3.82417963
46skin morphogenesis (GO:0043589)3.82160997
47positive regulation of interleukin-8 secretion (GO:2000484)3.81728293
48aromatic amino acid family catabolic process (GO:0009074)3.78495335
49high-density lipoprotein particle remodeling (GO:0034375)3.77537208
50intermediate filament cytoskeleton organization (GO:0045104)3.77155278
51phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.75975634
52triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.74432984
53regulation of cholesterol homeostasis (GO:2000188)3.73063059
54low-density lipoprotein particle remodeling (GO:0034374)3.71531340
55primary alcohol catabolic process (GO:0034310)3.69231397
56positive regulation of humoral immune response (GO:0002922)3.68887451
57negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.68197274
58phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.67479474
59bile acid and bile salt transport (GO:0015721)3.66430130
60intermediate filament-based process (GO:0045103)3.65807675
61kynurenine metabolic process (GO:0070189)3.64803454
62sulfur amino acid catabolic process (GO:0000098)3.63271400
63protein carboxylation (GO:0018214)3.62811743
64peptidyl-glutamic acid carboxylation (GO:0017187)3.62811743
65protein-lipid complex remodeling (GO:0034368)3.61201291
66macromolecular complex remodeling (GO:0034367)3.61201291
67plasma lipoprotein particle remodeling (GO:0034369)3.61201291
68uronic acid metabolic process (GO:0006063)3.56535648
69glucuronate metabolic process (GO:0019585)3.56535648
70regulation of keratinocyte differentiation (GO:0045616)3.56307015
71bile acid metabolic process (GO:0008206)3.53352060
72establishment of planar polarity (GO:0001736)3.51832063
73establishment of tissue polarity (GO:0007164)3.51832063
74bile acid biosynthetic process (GO:0006699)3.51469759
75regulation of phospholipase A2 activity (GO:0032429)3.49883772
76indole-containing compound catabolic process (GO:0042436)3.48988640
77indolalkylamine catabolic process (GO:0046218)3.48988640
78tryptophan catabolic process (GO:0006569)3.48988640
79intestinal epithelial cell development (GO:0060576)3.46662251
80urea cycle (GO:0000050)3.45679948
81urea metabolic process (GO:0019627)3.45679948
82negative regulation of fibrinolysis (GO:0051918)3.44476542
83keratinocyte development (GO:0003334)3.41634633
84cysteine metabolic process (GO:0006534)3.40617556
85regulation of glomerulus development (GO:0090192)3.39818213
86epithelium development (GO:0060429)3.37162496
87regulation of protein activation cascade (GO:2000257)3.35181716
88ethanol metabolic process (GO:0006067)3.32889356
89long-chain fatty acid biosynthetic process (GO:0042759)3.32287050
90response to nitrosative stress (GO:0051409)3.31527192
91regulation of fibrinolysis (GO:0051917)3.29356243
92citrulline biosynthetic process (GO:0019240)3.26598671
93regulation of bile acid biosynthetic process (GO:0070857)3.24000290
94alpha-linolenic acid metabolic process (GO:0036109)3.22601632
95ectoderm development (GO:0007398)3.21416410
96tryptophan metabolic process (GO:0006568)3.21046958
97complement activation, alternative pathway (GO:0006957)3.20391553
98phosphatidylcholine acyl-chain remodeling (GO:0036151)3.18874620
99very long-chain fatty acid metabolic process (GO:0000038)3.18699715
100regulation of cholesterol esterification (GO:0010872)3.18165466
101reverse cholesterol transport (GO:0043691)3.16355807
102regulation of complement activation (GO:0030449)3.16106540
103xenobiotic catabolic process (GO:0042178)3.14860376
104regulation of triglyceride catabolic process (GO:0010896)3.14810480
105virion attachment to host cell (GO:0019062)3.14404661
106adhesion of symbiont to host cell (GO:0044650)3.14404661
107nitrogen cycle metabolic process (GO:0071941)3.11803302
108adhesion of symbiont to host (GO:0044406)3.10457344
109regulation of epidermis development (GO:0045682)3.07061474
110acylglycerol homeostasis (GO:0055090)3.03813164
111triglyceride homeostasis (GO:0070328)3.03813164
112gap junction assembly (GO:0016264)3.03060006
113negative regulation of sterol transport (GO:0032372)3.02592285
114negative regulation of cholesterol transport (GO:0032375)3.02592285
115regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.02583922
116positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.02583922
117positive regulation of cholesterol efflux (GO:0010875)2.99769491
118glyoxylate metabolic process (GO:0046487)2.97142284
119regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.96795814
120negative regulation of keratinocyte proliferation (GO:0010839)2.95015466
121benzene-containing compound metabolic process (GO:0042537)2.93928243
122ceramide biosynthetic process (GO:0046513)2.91650575
123hormone catabolic process (GO:0042447)2.91311305
124amino-acid betaine metabolic process (GO:0006577)2.88942002
125fatty-acyl-CoA metabolic process (GO:0035337)2.87105806
126glutamate metabolic process (GO:0006536)2.83883773
127positive regulation of T-helper 1 type immune response (GO:0002827)2.83718117
128phosphatidylserine metabolic process (GO:0006658)2.83128495
129fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.81747823
130regulation of hair cycle (GO:0042634)2.80440311
131fatty-acyl-CoA biosynthetic process (GO:0046949)2.80079226
132intestinal cholesterol absorption (GO:0030299)2.79682921
133regulation of ruffle assembly (GO:1900027)2.79203679
134long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.78181599
135interferon-gamma secretion (GO:0072643)2.77973750
136plasma lipoprotein particle clearance (GO:0034381)2.77561662
137glutathione derivative biosynthetic process (GO:1901687)2.77434682
138glutathione derivative metabolic process (GO:1901685)2.77434682
139hypotonic response (GO:0006971)2.76672007
140positive regulation of transforming growth factor beta production (GO:0071636)2.75265352
141flavonoid metabolic process (GO:0009812)2.74799025
142regulation of epidermal cell differentiation (GO:0045604)2.73859641
143positive regulation of cholesterol transport (GO:0032376)2.72850991
144positive regulation of sterol transport (GO:0032373)2.72850991
145long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.72337201
146regulation of interleukin-8 secretion (GO:2000482)2.71974203
147hair cell differentiation (GO:0035315)2.71884207
148aromatic amino acid family metabolic process (GO:0009072)2.71450450
149eyelid development in camera-type eye (GO:0061029)2.70563253
150phosphatidylinositol acyl-chain remodeling (GO:0036149)2.70405504
151regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.67398710
152planar cell polarity pathway involved in neural tube closure (GO:0090179)2.65870103
153epithelial cell differentiation (GO:0030855)2.65741480
154early endosome to late endosome transport (GO:0045022)2.65690811
155regulation of cellular amide metabolic process (GO:0034248)2.63073866
156activation of MAPKKK activity (GO:0000185)2.60663813
157detection of external biotic stimulus (GO:0098581)2.60489836
158response to fungus (GO:0009620)2.58122042
159pyrimidine-containing compound transmembrane transport (GO:0072531)2.54767758
160polarized epithelial cell differentiation (GO:0030859)2.53512070
161apical protein localization (GO:0045176)2.52187184
162regulation of interleukin-17 production (GO:0032660)2.51006182
163nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.45892845
164regulation of axon regeneration (GO:0048679)2.40507841
165regulation of neuron projection regeneration (GO:0070570)2.40507841
166regulation of natural killer cell activation (GO:0032814)2.39305524
167atrioventricular valve morphogenesis (GO:0003181)2.39268835
168retinol metabolic process (GO:0042572)2.38262725
169cellular response to arsenic-containing substance (GO:0071243)2.36921555
170endothelial cell chemotaxis (GO:0035767)2.31988676
171hair cycle (GO:0042633)12.0440959
172molting cycle (GO:0042303)12.0440959

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.53201947
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.75963702
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.87161509
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.55553918
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.01888626
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.93153096
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.80843018
8P63_26484246_Chip-Seq_KERATINOCYTES_Human2.53111046
9* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.52652592
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.22585770
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.16693466
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.15020129
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.14606034
14ZNF263_19887448_ChIP-Seq_K562_Human2.10421585
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04392832
16TP63_17297297_ChIP-ChIP_HaCaT_Human11.2866080
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.94234613
18SOX9_24532713_ChIP-Seq_HFSC_Mouse1.93943334
19* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.80649379
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79973206
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.68799663
22CLOCK_20551151_ChIP-Seq_293T_Human1.67917434
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67370676
24SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67370676
25* FOXO3_23340844_ChIP-Seq_DLD1_Human1.64102166
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54995808
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47569266
28BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.45384642
29SOX2_20726797_ChIP-Seq_SW620_Human1.39169207
30RACK7_27058665_Chip-Seq_MCF-7_Human1.35115726
31SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31481008
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30615544
33GATA4_25053715_ChIP-Seq_YYC3_Human1.29872342
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29142999
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28261152
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27930631
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25863743
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.25416327
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25366997
40ATF3_27146783_Chip-Seq_COLON_Human1.25154763
41ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20330308
42RUNX1_27514584_Chip-Seq_MCF-7_Human1.20075117
43ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.16514122
44GATA3_24758297_ChIP-Seq_MCF-7_Human1.16308035
45ERG_20517297_ChIP-Seq_VCAP_Human1.14106741
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14033147
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.13198121
48GATA6_25053715_ChIP-Seq_YYC3_Human1.09690928
49LXR_22292898_ChIP-Seq_THP-1_Human1.05759626
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05499368
51TP63_22573176_ChIP-Seq_HFKS_Human1.05039642
52SMC4_20622854_ChIP-Seq_HELA_Human1.04596747
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04440135
54CTCF_27219007_Chip-Seq_Bcells_Human1.03496596
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02582957
56KLF5_25053715_ChIP-Seq_YYC3_Human1.02131872
57FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01369011
58FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99628978
59TP63_23658742_ChIP-Seq_EP156T_Human0.99556235
60DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97906406
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96925830
62CREB1_26743006_Chip-Seq_LNCaP_Human0.96574990
63TCF4_18268006_ChIP-ChIP_LS174T_Human0.94257305
64CJUN_26792858_Chip-Seq_BT549_Human0.94193498
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92333865
66ELK3_25401928_ChIP-Seq_HUVEC_Human0.92322210
67TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92131449
68EGR1_19032775_ChIP-ChIP_M12_Human0.91765611
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91690640
70CTCF_20526341_ChIP-Seq_ESCs_Human0.91405926
71AHR_22903824_ChIP-Seq_MCF-7_Human0.90845515
72ARNT_22903824_ChIP-Seq_MCF-7_Human0.90010670
73ERG_21242973_ChIP-ChIP_JURKAT_Human0.89181105
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89140239
75TP53_20018659_ChIP-ChIP_R1E_Mouse0.88563544
76* TCF7_22412390_ChIP-Seq_EML_Mouse0.88063765
77FOXA1_25552417_ChIP-Seq_VCAP_Human0.87894824
78GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87713985
79P68_20966046_ChIP-Seq_HELA_Human0.87618463
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86471073
81P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85858008
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85193792
83CEBPB_22108803_ChIP-Seq_LS180_Human0.84716259
84ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83345696
85RXR_22108803_ChIP-Seq_LS180_Human0.82945326
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82330402
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81925985
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81183262
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81140702
90FOXA2_19822575_ChIP-Seq_HepG2_Human0.81107040
91PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80997040
92SA1_27219007_Chip-Seq_ERYTHROID_Human0.80418668
93ELF5_23300383_ChIP-Seq_T47D_Human0.79745096
94FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79538408
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78941308
96RBPJ_21746931_ChIP-Seq_IB4_Human0.78238413
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77896894
98UBF1/2_26484160_Chip-Seq_HMECs_Human0.77597282
99TP53_18474530_ChIP-ChIP_U2OS_Human0.77575337
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77488278
101CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.77455165
102GATA6_21074721_ChIP-Seq_CACO-2_Human0.77299184
103P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77055676
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76787495
105STAT6_21828071_ChIP-Seq_BEAS2B_Human0.76031254
106TP53_16413492_ChIP-PET_HCT116_Human0.75974057
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75971577
108P53_21459846_ChIP-Seq_SAOS-2_Human0.75684484
109CSB_26484114_Chip-Seq_FIBROBLAST_Human0.74563947
110EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.73780935
111E2F1_20622854_ChIP-Seq_HELA_Human0.73656767
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.73466013
113GATA2_21666600_ChIP-Seq_HMVEC_Human0.72598915
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71805633
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71501504
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.71358054
117KDM2B_26808549_Chip-Seq_K562_Human0.70777877
118BCOR_27268052_Chip-Seq_Bcells_Human0.70077125
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70070328
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69039151
121VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.67953737
122BCAT_22108803_ChIP-Seq_LS180_Human0.67713660
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.67600311
124RXRA_24833708_ChIP-Seq_LIVER_Mouse0.66917706
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.65884309
126HNFA_21074721_ChIP-Seq_CACO-2_Human0.65364111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.47271964
2MP0000579_abnormal_nail_morphology4.96166342
3MP0010234_abnormal_vibrissa_follicle4.49176744
4MP0002254_reproductive_system_inflammat4.40013464
5MP0005275_abnormal_skin_tensile4.14508885
6MP0005501_abnormal_skin_physiology3.91659742
7MP0002139_abnormal_hepatobiliary_system3.54512241
8MP0002098_abnormal_vibrissa_morphology3.53432168
9MP0003705_abnormal_hypodermis_morpholog3.29039612
10MP0005085_abnormal_gallbladder_physiolo3.18575936
11MP0005360_urolithiasis3.12939062
12MP0000647_abnormal_sebaceous_gland3.01581620
13MP0000383_abnormal_hair_follicle2.96968996
14MP0004381_abnormal_hair_follicle2.90169981
15MP0001216_abnormal_epidermal_layer2.84301255
16MP0005365_abnormal_bile_salt2.79985312
17MP0010678_abnormal_skin_adnexa2.79843336
18MP0002060_abnormal_skin_morphology2.69360635
19MP0008875_abnormal_xenobiotic_pharmacok2.66397509
20MP0003941_abnormal_skin_development2.65830779
21MP0003453_abnormal_keratinocyte_physiol2.65180747
22MP0000467_abnormal_esophagus_morphology2.45542043
23MP0010771_integument_phenotype2.43770376
24MP0000377_abnormal_hair_follicle2.34303514
25MP0000427_abnormal_hair_cycle2.24567155
26MP0004947_skin_inflammation2.21530613
27MP0003191_abnormal_cellular_cholesterol1.97890903
28MP0005377_hearing/vestibular/ear_phenot1.86751888
29MP0003878_abnormal_ear_physiology1.86751888
30MP0005451_abnormal_body_composition1.86600996
31MP0001666_abnormal_nutrient_absorption1.81783602
32MP0003252_abnormal_bile_duct1.70685338
33MP0009840_abnormal_foam_cell1.68183902
34MP0005083_abnormal_biliary_tract1.66759643
35MP0000762_abnormal_tongue_morphology1.66650938
36MP0004885_abnormal_endolymph1.63687925
37MP0010329_abnormal_lipoprotein_level1.58051075
38MP0004043_abnormal_pH_regulation1.54208332
39MP0009931_abnormal_skin_appearance1.51835981
40MP0001188_hyperpigmentation1.49906827
41MP0001346_abnormal_lacrimal_gland1.49325505
42MP0004019_abnormal_vitamin_homeostasis1.44632549
43MP0003566_abnormal_cell_adhesion1.38278553
44MP0000367_abnormal_coat/_hair1.37488494
45MP0001191_abnormal_skin_condition1.34208513
46MP0001243_abnormal_dermal_layer1.32453058
47MP0003950_abnormal_plasma_membrane1.31048639
48MP0009053_abnormal_anal_canal1.23471462
49MP0003195_calcinosis1.21449164
50MP0002234_abnormal_pharynx_morphology1.19133504
51MP0000566_synostosis1.14693874
52MP0003806_abnormal_nucleotide_metabolis1.14287936
53MP0004185_abnormal_adipocyte_glucose1.08255876
54MP0004264_abnormal_extraembryonic_tissu1.07072134
55MP0004782_abnormal_surfactant_physiolog0.99908100
56MP0002118_abnormal_lipid_homeostasis0.97423080
57MP0003868_abnormal_feces_composition0.97235219
58MP0005023_abnormal_wound_healing0.94917923
59MP0009780_abnormal_chondrocyte_physiolo0.91212764
60MP0005332_abnormal_amino_acid0.87556448
61MP0000609_abnormal_liver_physiology0.86921400
62MP0002877_abnormal_melanocyte_morpholog0.86733168
63MP0001784_abnormal_fluid_regulation0.85483586
64MP0002138_abnormal_hepatobiliary_system0.85398620
65MP0001849_ear_inflammation0.84826584
66MP0010352_gastrointestinal_tract_polyps0.84244881
67MP0000678_abnormal_parathyroid_gland0.72176811
68MP0009379_abnormal_foot_pigmentation0.70181614
69MP0010030_abnormal_orbit_morphology0.69914326
70MP0001340_abnormal_eyelid_morphology0.69193854
71MP0000627_abnormal_mammary_gland0.67191846
72MP0005666_abnormal_adipose_tissue0.65775176
73MP0003656_abnormal_erythrocyte_physiolo0.64863443
74MP0000537_abnormal_urethra_morphology0.63074195
75MP0002095_abnormal_skin_pigmentation0.61113725
76MP0009333_abnormal_splenocyte_physiolog0.58797872
77MP0003011_delayed_dark_adaptation0.58080227
78MP0001851_eye_inflammation0.56339001
79MP0000538_abnormal_urinary_bladder0.56046316
80MP0005319_abnormal_enzyme/_coenzyme0.55138253
81MP0008004_abnormal_stomach_pH0.54945665
82MP0003329_amyloid_beta_deposits0.53782583
83MP0001765_abnormal_ion_homeostasis0.53724381
84MP0003638_abnormal_response/metabolism_0.52669425
85MP0001502_abnormal_circadian_rhythm0.51799832
86MP0005248_abnormal_Harderian_gland0.51644308
87MP0009643_abnormal_urine_homeostasis0.48688446
88MP0000465_gastrointestinal_hemorrhage0.47722740
89MP0000003_abnormal_adipose_tissue0.46511483
90MP0004197_abnormal_fetal_growth/weight/0.42352642
91MP0003828_pulmonary_edema0.41856302
92MP0000613_abnormal_salivary_gland0.41357016
93MP0009764_decreased_sensitivity_to0.39475222
94MP0003436_decreased_susceptibility_to0.38827762
95MP0000604_amyloidosis0.36603930
96MP0002282_abnormal_trachea_morphology0.36292252
97MP0002168_other_aberrant_phenotype0.34293660
98MP0000477_abnormal_intestine_morphology0.34203142
99MP0003755_abnormal_palate_morphology0.33002337
100MP0005165_increased_susceptibility_to0.32705810
101MP0002090_abnormal_vision0.32195548
102MP0005375_adipose_tissue_phenotype0.31718815
103MP0001873_stomach_inflammation0.31333021
104MP0001881_abnormal_mammary_gland0.31001213
105MP0002136_abnormal_kidney_physiology0.30831119
106MP0005220_abnormal_exocrine_pancreas0.30734076
107MP0005647_abnormal_sex_gland0.30675958
108MP0009384_cardiac_valve_regurgitation0.29478145
109MP0009765_abnormal_xenobiotic_induced0.29402285
110MP0002177_abnormal_outer_ear0.29230128
111MP0001727_abnormal_embryo_implantation0.26900413
112MP0000470_abnormal_stomach_morphology0.26872256
113MP0009763_increased_sensitivity_to0.26646683
114MP0008961_abnormal_basal_metabolism0.26440224
115MP0003300_gastrointestinal_ulcer0.26196717
116MP0005503_abnormal_tendon_morphology0.25682494
117MP0005334_abnormal_fat_pad0.25559555
118MP0002111_abnormal_tail_morphology0.25059810
119MP0005076_abnormal_cell_differentiation0.24744135
120MP0005409_darkened_coat_color0.24614798
121MP0003075_altered_response_to0.24508740
122MP0005584_abnormal_enzyme/coenzyme_acti0.24420394
123MP0001756_abnormal_urination0.24311385
124MP0005075_abnormal_melanosome_morpholog0.24181250
125MP0000685_abnormal_immune_system0.23713464
126MP0002166_altered_tumor_susceptibility0.22958115
127MP0001177_atelectasis0.21842712
128MP0010155_abnormal_intestine_physiology0.21006780
129MP0005388_respiratory_system_phenotype0.19911453
130MP0002133_abnormal_respiratory_system0.19911453
131MP0002009_preneoplasia0.18145512
132MP0005636_abnormal_mineral_homeostasis0.16574696
133MP0003763_abnormal_thymus_physiology0.16019705
134MP0002006_tumorigenesis0.15815543
135MP0001542_abnormal_bone_strength0.15749634
136MP0002089_abnormal_postnatal_growth/wei0.13798537
137MP0000432_abnormal_head_morphology0.13471548
138MP0009115_abnormal_fat_cell0.13456040
139MP0005508_abnormal_skeleton_morphology0.11296819
140MP0003315_abnormal_perineum_morphology0.11278079

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)7.44168070
2Woolly hair (HP:0002224)7.14554304
3Abnormality of nail color (HP:0100643)6.55967668
4Plantar hyperkeratosis (HP:0007556)6.11380981
5Palmoplantar hyperkeratosis (HP:0000972)5.88947762
6Right ventricular cardiomyopathy (HP:0011663)5.69840359
7Palmar hyperkeratosis (HP:0010765)5.52045937
8Fragile nails (HP:0001808)5.37631881
9Onycholysis (HP:0001806)5.33077429
10Pili torti (HP:0003777)5.18235123
11Thick nail (HP:0001805)5.07988074
12Milia (HP:0001056)4.91929308
13Alopecia of scalp (HP:0002293)4.91070904
14Pustule (HP:0200039)4.76712133
15Nail dystrophy (HP:0008404)4.73145060
16Congenital ichthyosiform erythroderma (HP:0007431)4.42373283
17Increased IgE level (HP:0003212)4.21503701
18Intrahepatic cholestasis (HP:0001406)4.12220010
19Xanthomatosis (HP:0000991)3.98269745
20Abnormal hair laboratory examination (HP:0003328)3.84570912
21Abnormal blistering of the skin (HP:0008066)3.79859947
22Erythema (HP:0010783)3.74463411
23Deep venous thrombosis (HP:0002625)3.73841232
24Brittle hair (HP:0002299)3.72403298
25Abnormality of monocarboxylic acid metabolism (HP:0010996)3.70376451
26Epidermoid cyst (HP:0200040)3.67484171
27Erythroderma (HP:0001019)3.54064635
28Lip pit (HP:0100267)3.38988535
29Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.35001253
30Abnormality of aromatic amino acid family metabolism (HP:0004338)3.32768738
31Abnormality of the salivary glands (HP:0010286)3.20367568
32Gangrene (HP:0100758)3.15997836
33Conjunctival hamartoma (HP:0100780)3.14392684
34Corneal erosion (HP:0200020)3.09411825
35Sparse eyelashes (HP:0000653)3.08605081
36Prolonged partial thromboplastin time (HP:0003645)3.06619751
37Hypobetalipoproteinemia (HP:0003563)3.04659949
38Slow-growing hair (HP:0002217)2.95517010
39Abnormality of hair growth rate (HP:0011363)2.95517010
40Hyperlipoproteinemia (HP:0010980)2.92583182
41Pruritus (HP:0000989)2.87058612
42Parakeratosis (HP:0001036)2.85299605
43Absent eyelashes (HP:0000561)2.84991146
44Palmoplantar keratoderma (HP:0000982)2.79989251
45Natal tooth (HP:0000695)2.73657973
46Advanced eruption of teeth (HP:0006288)2.72745292
47Hypoalphalipoproteinemia (HP:0003233)2.72132779
48Furrowed tongue (HP:0000221)2.72017806
49Ridged nail (HP:0001807)2.70941840
50Ectropion (HP:0000656)2.70433818
51Hypolipoproteinemia (HP:0010981)2.68553454
52Oral leukoplakia (HP:0002745)2.67172239
53Hypohidrosis (HP:0000966)2.62217188
54Chronic bronchitis (HP:0004469)2.62075238
55Complement deficiency (HP:0004431)2.61873102
56Atrophic scars (HP:0001075)2.60680758
57Distal lower limb muscle weakness (HP:0009053)2.57479398
58Curly hair (HP:0002212)2.56297478
59Follicular hyperkeratosis (HP:0007502)2.55554005
60Congenital, generalized hypertrichosis (HP:0004540)2.55256334
61Fat malabsorption (HP:0002630)2.48271164
62Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.45302487
63Neonatal onset (HP:0003623)2.41915084
64Ventricular tachycardia (HP:0004756)2.38128648
65Hyporeflexia of lower limbs (HP:0002600)2.35720723
66Hypergammaglobulinemia (HP:0010702)2.34277079
67Villous atrophy (HP:0011473)2.34195757
68Abnormality of small intestinal villus morphology (HP:0011472)2.34195757
69Abnormality of complement system (HP:0005339)2.33372197
70Acanthosis nigricans (HP:0000956)2.27145366
71Hyperactive renin-angiotensin system (HP:0000841)2.27115478
72Absent hair (HP:0002298)2.25205171
73Abnormality of the Achilles tendon (HP:0005109)2.24673683
74Blepharitis (HP:0000498)2.18435129
75Corneal dystrophy (HP:0001131)2.18330225
76Abnormality of glutamine family amino acid metabolism (HP:0010902)2.16405982
77Anonychia (HP:0001798)2.15618314
78Abnormality of the common coagulation pathway (HP:0010990)2.15304096
79Eczematoid dermatitis (HP:0000976)2.09533368
80Hypoplastic labia majora (HP:0000059)2.05894464
81Steatorrhea (HP:0002570)2.04635047
82Vascular calcification (HP:0004934)1.99038363
83Dry hair (HP:0011359)1.97327854
84Achilles tendon contracture (HP:0001771)1.96646827
85Oligodontia (HP:0000677)1.95478563
86Popliteal pterygium (HP:0009756)1.93455618
87Hyperkalemia (HP:0002153)1.93001835
88Myocardial infarction (HP:0001658)1.91018778
89Abnormality of sulfur amino acid metabolism (HP:0004339)1.90883978
90Esophageal varix (HP:0002040)1.89960071
91Joint hemorrhage (HP:0005261)1.89594679
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87048714
93Dry skin (HP:0000958)1.86986858
94Abnormality of the labia majora (HP:0012881)1.86923304
95Increased connective tissue (HP:0009025)1.86643880
96Hypercholesterolemia (HP:0003124)1.86626765
97Malnutrition (HP:0004395)1.86330790
98Dehydration (HP:0001944)1.85353817
99Hamartoma of the eye (HP:0010568)1.84317732
100Abnormality of secondary sexual hair (HP:0009888)1.83635663
101Abnormality of the axillary hair (HP:0100134)1.83635663
102Abnormality of the neuromuscular junction (HP:0003398)1.80899991
103Fatigable weakness (HP:0003473)1.80899991
104Hypoglycemic coma (HP:0001325)1.80314893
105Hyperammonemia (HP:0001987)1.79848391
106Cardiovascular calcification (HP:0011915)1.79421062
107Abnormality of the gastric mucosa (HP:0004295)1.78447607
108Neonatal death (HP:0003811)1.77725095
109Lack of skin elasticity (HP:0100679)1.77720286
110Abnormality of placental membranes (HP:0011409)1.77282425
111Amniotic constriction ring (HP:0009775)1.77282425
112Sparse scalp hair (HP:0002209)1.75585226
113Fine hair (HP:0002213)1.75126294
114Autoamputation (HP:0001218)1.73762376
115Ketosis (HP:0001946)1.72226226
116Abnormality of the dental root (HP:0006486)1.70206860
117Taurodontia (HP:0000679)1.70206860
118Abnormality of permanent molar morphology (HP:0011071)1.70206860
119Papilloma (HP:0012740)1.69503516
120Verrucae (HP:0200043)1.69503516
121Abnormality of aspartate family amino acid metabolism (HP:0010899)1.69108234
122Abnormality of the intrinsic pathway (HP:0010989)1.67806603
123Sepsis (HP:0100806)1.67269014
124Hyperhidrosis (HP:0000975)1.67051071
125Hypoplasia of dental enamel (HP:0006297)1.66561699
126Hyperglycinuria (HP:0003108)1.66416732
127Paralysis (HP:0003470)1.66126709
128Nasal polyposis (HP:0100582)1.65923954
129Septate vagina (HP:0001153)1.65801908
130Abnormality of methionine metabolism (HP:0010901)1.64628249
131Gout (HP:0001997)1.64588851
132Abnormal hemoglobin (HP:0011902)1.62843388
133Ventricular fibrillation (HP:0001663)1.60907969
134Laryngomalacia (HP:0001601)1.60115197
135Duplicated collecting system (HP:0000081)1.59503346
136Carious teeth (HP:0000670)1.59012292
137Abnormality of molar morphology (HP:0011070)1.56666519
138Abnormality of molar (HP:0011077)1.56666519
139Urticaria (HP:0001025)1.52702438
140Multifactorial inheritance (HP:0001426)1.51511164
141Abnormality of the fingernails (HP:0001231)1.50961881
142Abnormality of the dental pulp (HP:0006479)1.49062134
143Nasolacrimal duct obstruction (HP:0000579)1.45897670
144Skin ulcer (HP:0200042)1.44767622
145Recurrent corneal erosions (HP:0000495)1.44686579
146Selective tooth agenesis (HP:0001592)1.43649341
147Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.43351100
148Melanocytic nevus (HP:0000995)1.41562708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.41584678
2ERN14.26349361
3MAP3K33.70738684
4MAPKAPK33.46534222
5FER3.18529419
6MST1R2.76432251
7RPS6KB22.71502919
8MAP3K22.42235362
9CDK122.38906429
10TAOK12.38475253
11FGFR42.37545428
12MAP3K112.25948880
13EPHB22.10527568
14MST42.05835398
15LATS12.05828721
16FRK1.97097375
17RIPK11.90320259
18PTK61.88047256
19NME11.78542668
20TAOK31.67903314
21PIK3CG1.66602627
22SIK11.65919693
23SGK2231.60971767
24SGK4941.60971767
25WNK11.59266121
26BCKDK1.58667604
27TRIB31.57904483
28MAP2K21.45879281
29IKBKB1.40812336
30STK241.39263984
31MAP2K61.37986530
32MAP3K11.35271393
33MAP2K31.35227063
34IRAK11.34253247
35MAP3K71.28803510
36MAP2K41.26336843
37ERBB41.26281784
38PTK21.21603917
39MAP3K61.18477992
40IRAK21.17430175
41FGFR21.12022568
42IRAK41.11207691
43MAP2K11.05827273
44EEF2K1.05276850
45TESK11.04861621
46STK381.03607682
47PKN21.00956476
48SGK31.00392161
49MAP3K90.97897001
50MAP3K120.97726399
51SGK20.96984004
52MET0.96957453
53LATS20.96262834
54CDK60.95436485
55MAP3K140.93460708
56NEK60.92135066
57EPHB10.90409314
58PIM20.89811127
59TTN0.88946689
60CAMK1D0.88748257
61TYK20.88676487
62STK30.86770487
63ICK0.86292939
64FGFR10.86193351
65RPS6KA40.84414799
66TRPM70.82863601
67MTOR0.82346188
68MAP3K50.82180267
69DYRK1B0.80526538
70LRRK20.78683022
71PDGFRB0.77341372
72TAOK20.72679638
73MARK20.71099093
74WNK40.70192110
75EPHA40.69537059
76EPHA30.67581723
77MAP3K130.66394391
78MAPK150.66365073
79IRAK30.66237523
80MAPK110.66204336
81PRKD20.65815261
82MAPKAPK50.63941432
83ERBB20.63855121
84DAPK20.63725615
85FGFR30.62366523
86CAMK1G0.60891847
87ERBB30.60863025
88MAPKAPK20.59534805
89HIPK20.58976632
90AKT30.58530483
91TGFBR10.56818769
92BMX0.56622296
93RPS6KA20.56071597
94ADRBK10.55671980
95STK390.54402915
96BRD40.53702574
97SMG10.50338696
98PRKAA20.50013380
99ITK0.49736326
100TGFBR20.49659019
101BLK0.49559787
102PRKCI0.49107066
103SGK10.48708148
104GRK60.48677971
105RPS6KA10.45205207
106INSRR0.44800659
107STK38L0.44513664
108ABL20.42964076
109GRK10.41772836
110NEK90.41220030
111TYRO30.41014516
112JAK20.40410993
113GRK50.40392709
114MOS0.40387125
115CSK0.40156538
116MAPK40.40112274
117JAK10.39763419
118RPS6KC10.39410320
119RPS6KL10.39410320
120PAK30.39136322
121CAMK2G0.38588065
122RPS6KA60.37365704
123STK100.36990574
124KSR20.36615582
125GSK3A0.36388706
126PRKD10.36353441
127PRKCE0.35581484
128PIK3CA0.33645256
129STK110.33107448
130BCR0.31911563
131BMPR20.31622265
132MAPK120.31131362
133MAP3K100.29938802
134PIM10.29181096
135IKBKE0.29004042
136RET0.27327374
137RPS6KB10.27138260
138EIF2AK20.25239046
139CDK70.25236742
140PRKCA0.25212736
141DYRK30.25017023
142CHUK0.24962488
143TBK10.24878731
144MAPK70.23959385
145PRPF4B0.23506854
146PDPK10.23039825
147RIPK40.19773911

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.58729831
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.52286365
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.12392117
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.90924022
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.84117668
6Chemical carcinogenesis_Homo sapiens_hsa052042.73847732
7Nitrogen metabolism_Homo sapiens_hsa009102.57083856
8Histidine metabolism_Homo sapiens_hsa003402.40270885
9Arginine biosynthesis_Homo sapiens_hsa002202.36269386
10Phenylalanine metabolism_Homo sapiens_hsa003602.36150431
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.28487535
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28142596
13Fat digestion and absorption_Homo sapiens_hsa049752.18430397
14Steroid hormone biosynthesis_Homo sapiens_hsa001402.16629602
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.14384268
16Retinol metabolism_Homo sapiens_hsa008302.11022047
17Complement and coagulation cascades_Homo sapiens_hsa046102.07915387
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99589367
19Linoleic acid metabolism_Homo sapiens_hsa005911.95877756
20Fatty acid elongation_Homo sapiens_hsa000621.95867321
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.94494017
22Tryptophan metabolism_Homo sapiens_hsa003801.92808372
23Fatty acid degradation_Homo sapiens_hsa000711.82403064
24Caffeine metabolism_Homo sapiens_hsa002321.79788463
25PPAR signaling pathway_Homo sapiens_hsa033201.76709379
26beta-Alanine metabolism_Homo sapiens_hsa004101.74835191
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.62364657
28Tyrosine metabolism_Homo sapiens_hsa003501.59250623
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.56486796
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56407666
31Ovarian steroidogenesis_Homo sapiens_hsa049131.46551559
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.46199849
33Bile secretion_Homo sapiens_hsa049761.44680958
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44587816
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44191623
36Peroxisome_Homo sapiens_hsa041461.41106787
37Staphylococcus aureus infection_Homo sapiens_hsa051501.40733242
38Starch and sucrose metabolism_Homo sapiens_hsa005001.36588456
39Sulfur metabolism_Homo sapiens_hsa009201.35521496
40Butanoate metabolism_Homo sapiens_hsa006501.35466549
41Acute myeloid leukemia_Homo sapiens_hsa052211.34933633
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30151349
43Notch signaling pathway_Homo sapiens_hsa043301.25900923
44Choline metabolism in cancer_Homo sapiens_hsa052311.24267413
45Fatty acid metabolism_Homo sapiens_hsa012121.21627755
46Renal cell carcinoma_Homo sapiens_hsa052111.14707953
47Arachidonic acid metabolism_Homo sapiens_hsa005901.13841643
48ABC transporters_Homo sapiens_hsa020101.12445420
49Glutathione metabolism_Homo sapiens_hsa004801.12140990
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10846264
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07290434
52Ras signaling pathway_Homo sapiens_hsa040141.00349417
53p53 signaling pathway_Homo sapiens_hsa041151.00061116
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.99425171
55Endocytosis_Homo sapiens_hsa041440.99062759
56Serotonergic synapse_Homo sapiens_hsa047260.98708267
57Propanoate metabolism_Homo sapiens_hsa006400.97841701
58TNF signaling pathway_Homo sapiens_hsa046680.97627691
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97370813
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.96919346
61Long-term depression_Homo sapiens_hsa047300.96298670
62ErbB signaling pathway_Homo sapiens_hsa040120.95621381
63Steroid biosynthesis_Homo sapiens_hsa001000.91894759
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.91828904
65Collecting duct acid secretion_Homo sapiens_hsa049660.91761559
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90768496
67Inositol phosphate metabolism_Homo sapiens_hsa005620.90133586
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87869870
69MAPK signaling pathway_Homo sapiens_hsa040100.85973059
70Salivary secretion_Homo sapiens_hsa049700.83773499
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83165677
72Selenocompound metabolism_Homo sapiens_hsa004500.83135684
73T cell receptor signaling pathway_Homo sapiens_hsa046600.81330368
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80719663
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78997769
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.78305485
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77764674
78Ether lipid metabolism_Homo sapiens_hsa005650.74130785
79MicroRNAs in cancer_Homo sapiens_hsa052060.73731082
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73215329
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72595982
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71694558
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.70433564
84Folate biosynthesis_Homo sapiens_hsa007900.69637532
85FoxO signaling pathway_Homo sapiens_hsa040680.67840923
86Pyruvate metabolism_Homo sapiens_hsa006200.66871928
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66653642
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.66305224
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.65682447
90Vitamin digestion and absorption_Homo sapiens_hsa049770.64384663
91mTOR signaling pathway_Homo sapiens_hsa041500.61710519
92Arginine and proline metabolism_Homo sapiens_hsa003300.61652428
93Pancreatic cancer_Homo sapiens_hsa052120.60885712
94Chronic myeloid leukemia_Homo sapiens_hsa052200.60594359
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.60214583
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.59468274
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59085290
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58583985
99Prolactin signaling pathway_Homo sapiens_hsa049170.57473764
100Phototransduction_Homo sapiens_hsa047440.57352776
101Vibrio cholerae infection_Homo sapiens_hsa051100.56973795
102Prostate cancer_Homo sapiens_hsa052150.56572460
103Bladder cancer_Homo sapiens_hsa052190.55093000
104Axon guidance_Homo sapiens_hsa043600.54738499
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54170016
106Glycerolipid metabolism_Homo sapiens_hsa005610.52059066
107Biosynthesis of amino acids_Homo sapiens_hsa012300.51792914
108Carbon metabolism_Homo sapiens_hsa012000.51142239
109Platelet activation_Homo sapiens_hsa046110.49102289
110Toxoplasmosis_Homo sapiens_hsa051450.49002130
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.48773592
112Estrogen signaling pathway_Homo sapiens_hsa049150.48482863
113Sulfur relay system_Homo sapiens_hsa041220.47632518
114Insulin signaling pathway_Homo sapiens_hsa049100.46626725
115Pathways in cancer_Homo sapiens_hsa052000.46129937
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45997653
117B cell receptor signaling pathway_Homo sapiens_hsa046620.45913819
118Pancreatic secretion_Homo sapiens_hsa049720.43925317
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43065986
120Shigellosis_Homo sapiens_hsa051310.43057871
121Small cell lung cancer_Homo sapiens_hsa052220.42175214
122Influenza A_Homo sapiens_hsa051640.41453755
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40991494
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40496897
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40022175
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37991572
127Apoptosis_Homo sapiens_hsa042100.37701979
128Fatty acid biosynthesis_Homo sapiens_hsa000610.37386335
129Insulin resistance_Homo sapiens_hsa049310.35919059
130Lysine degradation_Homo sapiens_hsa003100.33267777
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.30390677
132Adherens junction_Homo sapiens_hsa045200.29037754
133Amoebiasis_Homo sapiens_hsa051460.27563892
134Tight junction_Homo sapiens_hsa045300.27347525
135Basal cell carcinoma_Homo sapiens_hsa052170.27236240
136VEGF signaling pathway_Homo sapiens_hsa043700.26558073
137ECM-receptor interaction_Homo sapiens_hsa045120.26265871
138Sphingolipid metabolism_Homo sapiens_hsa006000.24880290
139Mineral absorption_Homo sapiens_hsa049780.22613052
140Hepatitis C_Homo sapiens_hsa051600.21258871
141Galactose metabolism_Homo sapiens_hsa000520.19347137
142Proteoglycans in cancer_Homo sapiens_hsa052050.15872113
143Metabolic pathways_Homo sapiens_hsa011000.15801912
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15367057
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15149375
146Prion diseases_Homo sapiens_hsa050200.12399613
147Glucagon signaling pathway_Homo sapiens_hsa049220.11235261
148Thyroid cancer_Homo sapiens_hsa052160.10539715
149Hippo signaling pathway_Homo sapiens_hsa043900.08318457
150Melanogenesis_Homo sapiens_hsa049160.06530985
151Pentose phosphate pathway_Homo sapiens_hsa000300.05818270
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.05517139
153GnRH signaling pathway_Homo sapiens_hsa049120.05108478
154Protein digestion and absorption_Homo sapiens_hsa049740.04975051
155Renin secretion_Homo sapiens_hsa049240.04249072
156Fructose and mannose metabolism_Homo sapiens_hsa000510.03754358
157Dorso-ventral axis formation_Homo sapiens_hsa043200.03429140
158Circadian rhythm_Homo sapiens_hsa047100.02889696

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