RNF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.90849990
2purine nucleobase biosynthetic process (GO:0009113)4.66215105
3nucleobase biosynthetic process (GO:0046112)4.59511328
4protein localization to kinetochore (GO:0034501)4.55232522
5DNA replication initiation (GO:0006270)4.38100395
6nuclear pore organization (GO:0006999)4.24250874
7metaphase plate congression (GO:0051310)4.20253050
8mitotic nuclear envelope disassembly (GO:0007077)4.18763285
9DNA strand elongation involved in DNA replication (GO:0006271)4.06668228
10DNA replication checkpoint (GO:0000076)4.02860061
11IMP biosynthetic process (GO:0006188)3.99758819
12nuclear pore complex assembly (GO:0051292)3.97014421
13membrane disassembly (GO:0030397)3.89879369
14nuclear envelope disassembly (GO:0051081)3.89879369
15DNA strand elongation (GO:0022616)3.89396310
16DNA unwinding involved in DNA replication (GO:0006268)3.89210184
17protein localization to chromosome, centromeric region (GO:0071459)3.88101410
18* regulation of spindle organization (GO:0090224)3.74841531
19telomere maintenance via semi-conservative replication (GO:0032201)3.74257819
20folic acid-containing compound biosynthetic process (GO:0009396)3.73234871
21regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.70476276
22ribosome biogenesis (GO:0042254)3.67668975
23ribosome assembly (GO:0042255)3.66644451
24establishment of chromosome localization (GO:0051303)3.65764443
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.64813990
26CENP-A containing nucleosome assembly (GO:0034080)3.60630754
27DNA replication-dependent nucleosome organization (GO:0034723)3.54030147
28DNA replication-dependent nucleosome assembly (GO:0006335)3.54030147
29chromatin remodeling at centromere (GO:0031055)3.53286841
30telomere maintenance via recombination (GO:0000722)3.49845149
31IMP metabolic process (GO:0046040)3.49844391
32formation of translation preinitiation complex (GO:0001731)3.49841244
33maturation of 5.8S rRNA (GO:0000460)3.47860688
34mitotic sister chromatid segregation (GO:0000070)3.47344764
35mitotic chromosome condensation (GO:0007076)3.45318532
36establishment of integrated proviral latency (GO:0075713)3.44175732
37DNA replication-independent nucleosome assembly (GO:0006336)3.42286994
38DNA replication-independent nucleosome organization (GO:0034724)3.42286994
39attachment of spindle microtubules to kinetochore (GO:0008608)3.42184887
40mitotic recombination (GO:0006312)3.36264314
41regulation of mitotic spindle organization (GO:0060236)3.32975522
42spindle checkpoint (GO:0031577)3.29887825
43negative regulation of chromosome segregation (GO:0051985)3.29229587
44kinetochore organization (GO:0051383)3.28464879
45somatic hypermutation of immunoglobulin genes (GO:0016446)3.27931675
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.27931675
47negative regulation of mitotic sister chromatid separation (GO:2000816)3.27233892
48negative regulation of mitotic sister chromatid segregation (GO:0033048)3.27233892
49negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.27233892
50negative regulation of sister chromatid segregation (GO:0033046)3.27233892
51regulation of chromosome segregation (GO:0051983)3.26598711
52positive regulation of chromosome segregation (GO:0051984)3.21743914
53regulation of mitotic metaphase/anaphase transition (GO:0030071)3.20417753
54sister chromatid segregation (GO:0000819)3.20218044
55negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20145249
56mitotic sister chromatid cohesion (GO:0007064)3.19753349
57mitotic spindle assembly checkpoint (GO:0007094)3.18541528
58spindle assembly checkpoint (GO:0071173)3.17875144
59telomere maintenance via telomere lengthening (GO:0010833)3.17146564
60maturation of SSU-rRNA (GO:0030490)3.15934128
61mitotic spindle checkpoint (GO:0071174)3.15927615
62regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.15095077
63peptidyl-arginine omega-N-methylation (GO:0035247)3.14450233
64histone exchange (GO:0043486)3.13479219
65establishment of viral latency (GO:0019043)3.12792640
66postreplication repair (GO:0006301)3.08596967
67translesion synthesis (GO:0019985)3.08342635
68histone H2A monoubiquitination (GO:0035518)3.08194851
69meiotic chromosome segregation (GO:0045132)3.07991362
70kinetochore assembly (GO:0051382)3.07237982
71nuclear envelope organization (GO:0006998)3.06827857
72pore complex assembly (GO:0046931)3.04711883
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.01790240
74regulation of mitotic sister chromatid separation (GO:0010965)3.00678947
75regulation of mitotic sister chromatid segregation (GO:0033047)3.00678947
76regulation of sister chromatid segregation (GO:0033045)3.00678947
77rRNA modification (GO:0000154)2.97384041
78maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95943574
79protein localization to chromosome (GO:0034502)2.95189541
80activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.93831447
81dosage compensation (GO:0007549)2.93507992
82mismatch repair (GO:0006298)2.93155345
83chromosome segregation (GO:0007059)2.92670841
84ribonucleoprotein complex biogenesis (GO:0022613)2.90485456
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.86254844
86negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86000489
87monoubiquitinated protein deubiquitination (GO:0035520)2.84823047
88DNA geometric change (GO:0032392)2.83848414
89DNA duplex unwinding (GO:0032508)2.83405688
90regulation of double-strand break repair via homologous recombination (GO:0010569)2.81982480
91regulation of centrosome cycle (GO:0046605)2.80206369
92rRNA processing (GO:0006364)2.80179663
93chromatin assembly or disassembly (GO:0006333)2.79977245
94folic acid metabolic process (GO:0046655)2.79606518
95regulation of nuclear cell cycle DNA replication (GO:0033262)2.77324932
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76789177
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76789177
98positive regulation of mitotic sister chromatid separation (GO:1901970)2.76789177
99negative thymic T cell selection (GO:0045060)2.76347383
100histone arginine methylation (GO:0034969)2.75836641
101G1/S transition of mitotic cell cycle (GO:0000082)2.74408956
102cell cycle G1/S phase transition (GO:0044843)2.74408956
103negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.73529863
104negative regulation of ligase activity (GO:0051352)2.73529863
105spliceosomal snRNP assembly (GO:0000387)2.73071711
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73048347
107rRNA metabolic process (GO:0016072)2.72930827
108ATP-dependent chromatin remodeling (GO:0043044)2.71824048
109peptidyl-arginine N-methylation (GO:0035246)2.70077477
110peptidyl-arginine methylation (GO:0018216)2.70077477
111regulation of sister chromatid cohesion (GO:0007063)2.69377883
112positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.69309107
113negative T cell selection (GO:0043383)2.68248164
114replication fork processing (GO:0031297)2.68087471
115tRNA methylation (GO:0030488)2.66213715
116NIK/NF-kappaB signaling (GO:0038061)2.65395245
117chaperone mediated protein folding requiring cofactor (GO:0051085)2.56439497
118positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.50172508
119protein complex localization (GO:0031503)2.47264770
120base-excision repair (GO:0006284)2.46165576
121signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.44148665
122signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.44148665
123signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.44148665
124DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.42369686
125intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.40845809
126signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.40845809
127signal transduction involved in DNA integrity checkpoint (GO:0072401)2.40741360
128signal transduction involved in DNA damage checkpoint (GO:0072422)2.40741360
129regulation of translational termination (GO:0006449)2.38891276
130cellular response to interleukin-15 (GO:0071350)2.38603912
131mitochondrial RNA metabolic process (GO:0000959)2.37972207
132peptidyl-histidine modification (GO:0018202)2.36959165
133tRNA aminoacylation for protein translation (GO:0006418)2.36675052
134DNA topological change (GO:0006265)2.36633988
135spliceosomal tri-snRNP complex assembly (GO:0000244)2.36392983
136signal transduction involved in cell cycle checkpoint (GO:0072395)2.36165595
137positive regulation of protein homooligomerization (GO:0032464)2.36008384
138regulation of exit from mitosis (GO:0007096)2.32908697
139amino acid activation (GO:0043038)2.32724294
140tRNA aminoacylation (GO:0043039)2.32724294
141cellular response to interleukin-4 (GO:0071353)2.32590958
142T cell migration (GO:0072678)2.32449235
143negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.32266127
144DNA catabolic process, exonucleolytic (GO:0000738)2.30938967
145transcription-coupled nucleotide-excision repair (GO:0006283)2.30813618
146positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.29625284
147B cell homeostasis (GO:0001782)2.29518196
148regulation of ubiquitin-protein transferase activity (GO:0051438)2.28686683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.69604970
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.30904034
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.90485812
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63699129
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.27535578
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01124441
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72620666
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69852318
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67680926
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.50987471
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50664595
12* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45622624
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40148545
14* GABP_17652178_ChIP-ChIP_JURKAT_Human2.40057073
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38338603
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.36722126
17AR_21909140_ChIP-Seq_LNCAP_Human2.35899315
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32611612
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.28259136
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.21008946
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.13719207
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.09517655
23XRN2_22483619_ChIP-Seq_HELA_Human2.07665800
24VDR_23849224_ChIP-Seq_CD4+_Human2.04692356
25* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.01442801
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96802916
27* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95305156
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90701617
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89663888
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89290388
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88343957
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87263825
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85798967
34FOXP3_21729870_ChIP-Seq_TREG_Human1.81181952
35DCP1A_22483619_ChIP-Seq_HELA_Human1.77785280
36* GABP_19822575_ChIP-Seq_HepG2_Human1.74397823
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73683867
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64802836
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.62919251
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61384484
41* ELK1_19687146_ChIP-ChIP_HELA_Human1.61087864
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59518213
43MYB_26560356_Chip-Seq_TH2_Human1.56747536
44MYC_22102868_ChIP-Seq_BL_Human1.55120894
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54951557
46* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54596422
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54387713
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53666171
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.52335180
50* TTF2_22483619_ChIP-Seq_HELA_Human1.49613636
51* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48115181
52KDM5A_27292631_Chip-Seq_BREAST_Human1.45886221
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43372647
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42075370
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41443791
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41439824
57* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38745661
58CIITA_25753668_ChIP-Seq_RAJI_Human1.38579442
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36149285
60MYB_26560356_Chip-Seq_TH1_Human1.33652629
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32174793
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31141485
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31067374
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30923905
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30845966
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29897828
67* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29274299
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29145715
69* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28712769
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.27546199
71MAF_26560356_Chip-Seq_TH1_Human1.23569339
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.21536323
73TFEB_21752829_ChIP-Seq_HELA_Human1.20005642
74* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19858297
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18830782
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18494873
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18054153
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.16750849
79* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13365809
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11868916
81* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09135197
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08257465
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.07591480
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07336759
85* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06592992
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05634601
87UTX_26944678_Chip-Seq_JUKART_Human1.04311407
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03727558
89MAF_26560356_Chip-Seq_TH2_Human1.02527312
90* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02036228
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01462478
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99520185
93NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99169349
94IRF8_22096565_ChIP-ChIP_GC-B_Human0.99046528
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98468960
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97901227
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96286238
98* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95948217
99TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95790472
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95590776
101* NANOG_21062744_ChIP-ChIP_HESCs_Human0.95032683
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94545857
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93779519
104RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93368373
105* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91760525
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91685619
107FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91591641
108RUNX1_22412390_ChIP-Seq_EML_Mouse0.91071779
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90914991
110* VDR_21846776_ChIP-Seq_THP-1_Human0.90904693
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90826981
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90543837
113* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90004818
114* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88805111
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88618151
116* SPI1_23547873_ChIP-Seq_NB4_Human0.85155899
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81242822
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79540120
119MYC_18940864_ChIP-ChIP_HL60_Human0.78969743
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78635108
121CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.76829877
122TCF3_18692474_ChIP-Seq_MESCs_Mouse0.74576653

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.96273926
2MP0010094_abnormal_chromosome_stability4.33543526
3MP0003111_abnormal_nucleus_morphology4.04829441
4MP0003077_abnormal_cell_cycle3.78930261
5MP0004957_abnormal_blastocyst_morpholog3.77012800
6MP0008057_abnormal_DNA_replication3.45582917
7MP0008058_abnormal_DNA_repair3.20223057
8MP0008007_abnormal_cellular_replicative3.05565409
9MP0002396_abnormal_hematopoietic_system2.57568313
10MP0005671_abnormal_response_to2.52146950
11MP0010352_gastrointestinal_tract_polyps2.43614991
12MP0001730_embryonic_growth_arrest2.27149385
13MP0010307_abnormal_tumor_latency2.26095899
14MP0000350_abnormal_cell_proliferation2.20670287
15MP0008932_abnormal_embryonic_tissue2.18136840
16MP0003123_paternal_imprinting2.14038625
17MP0001873_stomach_inflammation2.05336549
18MP0002254_reproductive_system_inflammat1.95118445
19MP0001800_abnormal_humoral_immune1.89114904
20MP0001835_abnormal_antigen_presentation1.86569725
21MP0008260_abnormal_autophagy1.84756561
22MP0005380_embryogenesis_phenotype1.82878390
23MP0001672_abnormal_embryogenesis/_devel1.82878390
24MP0003718_maternal_effect1.80334442
25MP0004808_abnormal_hematopoietic_stem1.78790656
26MP0003786_premature_aging1.74657624
27MP0000685_abnormal_immune_system1.73383787
28MP0005000_abnormal_immune_tolerance1.72230707
29MP0003984_embryonic_growth_retardation1.65296064
30MP0001697_abnormal_embryo_size1.63945335
31MP0002420_abnormal_adaptive_immunity1.61839939
32MP0002088_abnormal_embryonic_growth/wei1.61131085
33MP0003436_decreased_susceptibility_to1.60897485
34MP0002452_abnormal_antigen_presenting1.60337817
35MP0001819_abnormal_immune_cell1.59829865
36MP0000490_abnormal_crypts_of1.58485049
37MP0002723_abnormal_immune_serum1.56016377
38MP0002086_abnormal_extraembryonic_tissu1.53599477
39MP0009333_abnormal_splenocyte_physiolog1.50626789
40* MP0002080_prenatal_lethality1.48411778
41MP0002085_abnormal_embryonic_tissue1.46945453
42MP0002084_abnormal_developmental_patter1.46287525
43MP0002019_abnormal_tumor_incidence1.44901622
44MP0001545_abnormal_hematopoietic_system1.44608354
45MP0005397_hematopoietic_system_phenotyp1.44608354
46MP0004197_abnormal_fetal_growth/weight/1.44000674
47MP0003806_abnormal_nucleotide_metabolis1.36487713
48MP0005076_abnormal_cell_differentiation1.35461106
49MP0002405_respiratory_system_inflammati1.33558408
50MP0004233_abnormal_muscle_weight1.32900338
51MP0006035_abnormal_mitochondrial_morpho1.30670241
52MP0002210_abnormal_sex_determination1.27975270
53MP0005387_immune_system_phenotype1.27746191
54MP0001790_abnormal_immune_system1.27746191
55MP0003567_abnormal_fetal_cardiomyocyte1.26124363
56MP0000313_abnormal_cell_death1.24543286
57MP0004947_skin_inflammation1.22922863
58MP0009785_altered_susceptibility_to1.22306048
59MP0009053_abnormal_anal_canal1.19541488
60MP0005310_abnormal_salivary_gland1.18763100
61MP0002148_abnormal_hypersensitivity_rea1.16589048
62MP0001853_heart_inflammation1.15588975
63MP0003705_abnormal_hypodermis_morpholog1.14786800
64MP0003191_abnormal_cellular_cholesterol1.14055349
65MP0005025_abnormal_response_to1.13775257
66MP0003303_peritoneal_inflammation1.13603793
67MP0003121_genomic_imprinting1.12153121
68MP0001145_abnormal_male_reproductive1.11225186
69MP0001119_abnormal_female_reproductive1.11183543
70* MP0008877_abnormal_DNA_methylation1.10523278
71MP0005075_abnormal_melanosome_morpholog1.10470168
72MP0003890_abnormal_embryonic-extraembry1.09061318
73MP0002166_altered_tumor_susceptibility1.08311083
74MP0010030_abnormal_orbit_morphology1.06597303
75MP0002877_abnormal_melanocyte_morpholog1.05864963
76MP0003763_abnormal_thymus_physiology1.04736377
77MP0000653_abnormal_sex_gland1.01211679
78MP0002419_abnormal_innate_immunity1.00856203
79MP0002006_tumorigenesis1.00787988
80MP0001929_abnormal_gametogenesis1.00230355
81MP0005023_abnormal_wound_healing1.00046260
82MP0001915_intracranial_hemorrhage0.99958376
83MP0002398_abnormal_bone_marrow0.98467739
84MP0006054_spinal_hemorrhage0.98120637
85MP0001293_anophthalmia0.96033086
86MP0003943_abnormal_hepatobiliary_system0.95428281
87MP0004264_abnormal_extraembryonic_tissu0.95026083
88MP0009278_abnormal_bone_marrow0.94110521
89MP0003186_abnormal_redox_activity0.93717319
90MP0001849_ear_inflammation0.93382466
91MP0005499_abnormal_olfactory_system0.93030023
92MP0005394_taste/olfaction_phenotype0.93030023
93MP0000858_altered_metastatic_potential0.92849966
94MP0000689_abnormal_spleen_morphology0.92099947
95MP0002722_abnormal_immune_system0.91542289
96MP0000703_abnormal_thymus_morphology0.91310763
97MP0002653_abnormal_ependyma_morphology0.90827518
98MP0002132_abnormal_respiratory_system0.90453354
99MP0001845_abnormal_inflammatory_respons0.90405577
100MP0001348_abnormal_lacrimal_gland0.89640054
101MP0005621_abnormal_cell_physiology0.87698416
102MP0003221_abnormal_cardiomyocyte_apopto0.87486332
103MP0001346_abnormal_lacrimal_gland0.86787945
104MP0005389_reproductive_system_phenotype0.85803127
105MP0002160_abnormal_reproductive_system0.85106371
106MP0000015_abnormal_ear_pigmentation0.84203888
107MP0003941_abnormal_skin_development0.83693972
108MP0008789_abnormal_olfactory_epithelium0.83667589
109MP0003566_abnormal_cell_adhesion0.82161775
110MP0001727_abnormal_embryo_implantation0.82104398
111MP0005384_cellular_phenotype0.80913195
112MP0003937_abnormal_limbs/digits/tail_de0.79052460
113MP0009672_abnormal_birth_weight0.79038711
114MP0003300_gastrointestinal_ulcer0.78850909
115MP0003315_abnormal_perineum_morphology0.77575951
116MP0010155_abnormal_intestine_physiology0.76819358
117MP0009764_decreased_sensitivity_to0.76053915
118MP0003119_abnormal_digestive_system0.75834613
119MP0002429_abnormal_blood_cell0.75371126
120MP0009697_abnormal_copulation0.75141115
121MP0009840_abnormal_foam_cell0.73747512
122MP0002111_abnormal_tail_morphology0.73234235
123MP0006292_abnormal_olfactory_placode0.72338985
124MP0006082_CNS_inflammation0.71185035
125MP0003699_abnormal_female_reproductive0.70892802
126MP0000358_abnormal_cell_content/0.69662663
127MP0000627_abnormal_mammary_gland0.69558146
128MP0000477_abnormal_intestine_morphology0.65876088
129MP0001919_abnormal_reproductive_system0.65410524
130MP0000598_abnormal_liver_morphology0.64038172
131MP0005395_other_phenotype0.64027457
132MP0002938_white_spotting0.63905118
133MP0000716_abnormal_immune_system0.63123471
134MP0003448_altered_tumor_morphology0.62730843
135MP0002092_abnormal_eye_morphology0.61750797
136MP0002075_abnormal_coat/hair_pigmentati0.60506290
137MP0009703_decreased_birth_body0.59524400
138MP0000465_gastrointestinal_hemorrhage0.59400260
139MP0004133_heterotaxia0.58804328
140MP0001286_abnormal_eye_development0.58076796
141MP0003936_abnormal_reproductive_system0.56248022
142MP0000428_abnormal_craniofacial_morphol0.54837442
143MP0005408_hypopigmentation0.51693541

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.81596316
2Breast hypoplasia (HP:0003187)3.98039305
3Chromsome breakage (HP:0040012)3.76682241
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.66319754
5Patellar aplasia (HP:0006443)3.43343789
6Medulloblastoma (HP:0002885)3.33612674
7Degeneration of anterior horn cells (HP:0002398)3.33015972
8Abnormality of the anterior horn cell (HP:0006802)3.33015972
9Microvesicular hepatic steatosis (HP:0001414)3.26318711
10Impulsivity (HP:0100710)3.24990883
11Ependymoma (HP:0002888)3.23692516
12Carpal bone hypoplasia (HP:0001498)3.19474982
13Aplasia/Hypoplasia of the patella (HP:0006498)3.18378281
14IgG deficiency (HP:0004315)3.17986359
15IgA deficiency (HP:0002720)3.16030426
16Agnosia (HP:0010524)3.14731076
17Abnormality of chromosome stability (HP:0003220)3.13743769
18IgM deficiency (HP:0002850)3.12806860
19Oral leukoplakia (HP:0002745)3.12489366
20Colon cancer (HP:0003003)3.07161341
21Meckel diverticulum (HP:0002245)3.03174449
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.90046573
23Abnormality of the ileum (HP:0001549)2.89703517
24Abnormality of the labia minora (HP:0012880)2.87567308
25Aplastic anemia (HP:0001915)2.86997652
26Abnormality of the preputium (HP:0100587)2.86920048
27Nephroblastoma (Wilms tumor) (HP:0002667)2.80568530
28Rhabdomyosarcoma (HP:0002859)2.80537741
29Myelodysplasia (HP:0002863)2.75324759
30Selective tooth agenesis (HP:0001592)2.70203204
31Cortical dysplasia (HP:0002539)2.65586913
32Duodenal stenosis (HP:0100867)2.56559788
33Small intestinal stenosis (HP:0012848)2.56559788
34Embryonal renal neoplasm (HP:0011794)2.54564142
35Entropion (HP:0000621)2.53385440
36Rough bone trabeculation (HP:0100670)2.51442019
37Increased IgM level (HP:0003496)2.50108893
38Neoplasm of the pancreas (HP:0002894)2.49351159
39Lymphopenia (HP:0001888)2.49267711
40Upper limb muscle weakness (HP:0003484)2.47935293
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.44406247
42Abnormal protein N-linked glycosylation (HP:0012347)2.44406247
43Abnormal protein glycosylation (HP:0012346)2.44406247
44Abnormal glycosylation (HP:0012345)2.44406247
45Abnormality of glycolysis (HP:0004366)2.42762912
46T lymphocytopenia (HP:0005403)2.41658626
47Amaurosis fugax (HP:0100576)2.41186207
48Recurrent viral infections (HP:0004429)2.40190505
49Bone marrow hypocellularity (HP:0005528)2.40064112
5011 pairs of ribs (HP:0000878)2.39516291
51Type I transferrin isoform profile (HP:0003642)2.37715323
52Ectopic kidney (HP:0000086)2.36906441
53Combined immunodeficiency (HP:0005387)2.36427114
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.34050734
55B lymphocytopenia (HP:0010976)2.31642091
56Stomatitis (HP:0010280)2.30433992
57Panhypogammaglobulinemia (HP:0003139)2.30049598
58Prostate neoplasm (HP:0100787)2.30009601
59Abnormality of the astrocytes (HP:0100707)2.23666905
60Astrocytoma (HP:0009592)2.23666905
61Long palpebral fissure (HP:0000637)2.21871259
62Sloping forehead (HP:0000340)2.21754937
63Basal cell carcinoma (HP:0002671)2.21696461
64Slender long bone (HP:0003100)2.19641044
65Prominent metopic ridge (HP:0005487)2.19237372
66Absent radius (HP:0003974)2.18835686
67Acute myeloid leukemia (HP:0004808)2.18260977
68Abnormality of the duodenum (HP:0002246)2.15327270
69Facial hemangioma (HP:0000329)2.14040193
70Cholecystitis (HP:0001082)2.13754640
71Abnormal gallbladder physiology (HP:0012438)2.13754640
72Absent thumb (HP:0009777)2.13007094
73Abnormality of T cell number (HP:0011839)2.11479127
74Premature graying of hair (HP:0002216)2.10484997
75Deviation of the thumb (HP:0009603)2.10382217
76Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10280826
77Progressive external ophthalmoplegia (HP:0000590)2.09918974
78Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.09494967
79Supernumerary spleens (HP:0009799)2.09006951
80Increased serum pyruvate (HP:0003542)2.07521849
81Glioma (HP:0009733)2.04579600
82Cutaneous melanoma (HP:0012056)2.04355792
83Squamous cell carcinoma (HP:0002860)2.04094735
84Proximal placement of thumb (HP:0009623)2.03616305
85Abnormality of the carotid arteries (HP:0005344)2.01704622
86Capillary hemangiomas (HP:0005306)2.01613600
87Abnormal delayed hypersensitivity skin test (HP:0002963)2.00763251
88Amyotrophic lateral sclerosis (HP:0007354)2.00636786
89Absent forearm bone (HP:0003953)2.00338821
90Aplasia involving forearm bones (HP:0009822)2.00338821
91Deep philtrum (HP:0002002)2.00143346
92Microretrognathia (HP:0000308)1.98522503
93Abnormality of T cells (HP:0002843)1.96358806
94Reticulocytopenia (HP:0001896)1.94455362
95Cafe-au-lait spot (HP:0000957)1.94285789
96Spinal cord lesions (HP:0100561)1.93689897
97Syringomyelia (HP:0003396)1.93689897
98Pustule (HP:0200039)1.93140032
99Abnormality of B cell number (HP:0010975)1.92268817
100Tracheoesophageal fistula (HP:0002575)1.92152747
101Biliary tract neoplasm (HP:0100574)1.92120040
102Neoplasm of the oral cavity (HP:0100649)1.91972321
103Abnormal spermatogenesis (HP:0008669)1.91693227
104Abnormal lung lobation (HP:0002101)1.91284793
105Abnormality of the metopic suture (HP:0005556)1.90738146
106Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.90611151
107Short 4th metacarpal (HP:0010044)1.90611151
108Atresia of the external auditory canal (HP:0000413)1.90158563
109Loss of speech (HP:0002371)1.88411504
110Neoplasm of striated muscle (HP:0009728)1.88342214
111Trigonocephaly (HP:0000243)1.87874935
112Severe combined immunodeficiency (HP:0004430)1.87424855
113Thrombocytosis (HP:0001894)1.87338944
114Abnormal trabecular bone morphology (HP:0100671)1.87140575
115Progressive inability to walk (HP:0002505)1.87033141
116Neoplasm of the colon (HP:0100273)1.86870357
117Prominent nose (HP:0000448)1.85887884
118Abnormality of the calcaneus (HP:0008364)1.85700847
119Clubbing of toes (HP:0100760)1.84816984
120Stillbirth (HP:0003826)1.84371069
121Granulocytopenia (HP:0001913)1.83694127
122Chronic mucocutaneous candidiasis (HP:0002728)1.83576763
123Recurrent cutaneous fungal infections (HP:0011370)1.83576763
124Breast aplasia (HP:0100783)1.83496334
125Poikiloderma (HP:0001029)1.82315080
126Missing ribs (HP:0000921)1.82001167
127Premature ovarian failure (HP:0008209)1.81782401
128Mediastinal lymphadenopathy (HP:0100721)1.81691193
129Short thumb (HP:0009778)1.81171596
130Horseshoe kidney (HP:0000085)1.80894060
131Multiple enchondromatosis (HP:0005701)1.80843787
132High anterior hairline (HP:0009890)1.80156137
133Aplasia/Hypoplasia of the sternum (HP:0006714)1.79973516
134Progressive muscle weakness (HP:0003323)1.78045727
135Abnormality of the prostate (HP:0008775)1.77967309
136Increased nuchal translucency (HP:0010880)1.77772841
137Cerebral hypomyelination (HP:0006808)1.77692493
138Autoimmune hemolytic anemia (HP:0001890)1.77417305
139Muscle fiber atrophy (HP:0100295)1.77295693
140Reduced antithrombin III activity (HP:0001976)1.77071736
141Freckling (HP:0001480)1.77040940
142Abnormality of DNA repair (HP:0003254)1.76179922
143Recurrent fungal infections (HP:0002841)1.75824031
144Uterine leiomyosarcoma (HP:0002891)1.75305548
145Leiomyosarcoma (HP:0100243)1.75305548
146Secondary amenorrhea (HP:0000869)1.75296825
147Abnormality of pyrimidine metabolism (HP:0004353)1.75028408
148Transitional cell carcinoma of the bladder (HP:0006740)1.75006963
149Trismus (HP:0000211)1.74944382
150Sparse lateral eyebrow (HP:0005338)1.74447443
151Lymphoma (HP:0002665)1.73543460
152Elevated erythrocyte sedimentation rate (HP:0003565)1.73410831
153Atrophy/Degeneration involving motor neurons (HP:0007373)1.73010146
154Ankle contracture (HP:0006466)1.70817254
155Triphalangeal thumb (HP:0001199)1.70737924
156Cellular immunodeficiency (HP:0005374)1.70714149
157Abnormal number of erythroid precursors (HP:0012131)1.70408206
158Stenosis of the external auditory canal (HP:0000402)1.70240416
159Progressive hearing impairment (HP:0001730)1.70157935
160Leukopenia (HP:0001882)1.69640891
161Melanoma (HP:0002861)1.69164966
162Abnormality of cells of the erythroid lineage (HP:0012130)1.68918363
163Tongue fasciculations (HP:0001308)1.68454721
164Eosinophilia (HP:0001880)1.67146219
165Abnormality of eosinophils (HP:0001879)1.65716488
166Neoplasm of the adrenal cortex (HP:0100641)1.65234822

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.09375595
2BUB13.63147094
3CDC73.59197629
4EIF2AK12.97951462
5SIK32.89309211
6NEK22.61995167
7MST42.60624910
8SRPK12.44310396
9TRIM282.41757259
10TSSK62.40334496
11BRSK22.39852266
12SMG12.39665400
13VRK22.31645720
14PRPF4B2.26839496
15TTK2.23994459
16ACVR1B2.18487702
17PLK42.14390203
18NEK11.99728917
19PLK11.96587686
20PBK1.92406315
21MKNK11.80881623
22EPHA21.77463563
23RPS6KA41.77153196
24EIF2AK31.75689016
25DYRK31.73601338
26PLK31.68046016
27EEF2K1.65031249
28CDK71.63735896
29CDK121.63651853
30PASK1.62471490
31ATR1.60735907
32RPS6KB21.60581111
33AURKB1.54200338
34STK38L1.48951177
35MAP3K141.48276649
36MAP3K31.47108948
37VRK11.43632079
38CCNB11.42843944
39CHEK21.42380357
40NUAK11.39438184
41MKNK21.39353545
42NME21.37699194
43CDK41.36618302
44STK101.33592450
45BCR1.32686230
46STK31.32370479
47MAP2K31.31531575
48TGFBR11.28627580
49TESK21.27985176
50IRAK41.27811216
51MAP3K81.26246004
52CLK11.24041183
53FLT31.19591189
54BRSK11.19125926
55LATS11.15636804
56CHEK11.13324430
57ZAK1.13197484
58TAF11.04604015
59LATS21.02341163
60AURKA1.00254255
61PAK41.00113028
62PIM10.99783977
63STK40.98635358
64IKBKE0.97677356
65NEK90.97448821
66KIT0.96071922
67MAP3K100.94712227
68GRK60.91340300
69MARK30.90834234
70BRD40.84115366
71TBK10.83562749
72ATM0.82105492
73TAOK30.80962565
74CDK60.80693758
75MELK0.79431313
76CDK20.77866124
77PRKD20.77798183
78EIF2AK20.77698668
79IRAK30.76892108
80CSNK1G30.76133361
81MAP3K130.76123552
82CDK80.75224338
83PIM20.74941803
84CSNK1A1L0.73418948
85JAK30.73064516
86STK160.71825031
87PKN20.71559408
88MAPKAPK30.71042205
89SCYL20.70555695
90ARAF0.67814453
91PRKD30.67132756
92CSNK1G10.66186273
93LCK0.62656588
94AKT30.62575431
95MAPK110.59296684
96CDK190.59181980
97CDK10.58969479
98TRIB30.58867100
99CHUK0.58796278
100JAK10.57087266
101TYK20.56690483
102PAK10.53673317
103DYRK20.53282053
104CSNK2A10.52323077
105MTOR0.52055684
106FGR0.50668264
107FGFR40.50036868
108ALK0.49491167
109PRKCQ0.49131213
110ERBB40.48364463
111TESK10.48244912
112ZAP700.48085124
113PDK40.47999431
114PDK30.47999431
115CSNK2A20.47656057
116STK240.47368549
117TLK10.46136692
118PAK20.46062613
119MAP4K10.46002349
120BRAF0.43597511
121RPS6KA50.43156143
122KDR0.42441558
123HCK0.40686330
124MAPKAPK20.39854949
125PRKCI0.39433959
126NEK60.38632622
127MAP3K50.38028072
128BTK0.37871355
129DYRK1B0.37327654
130CDK90.36673683
131PDK20.35059980
132IKBKB0.34659699
133PIK3CG0.32833262
134FGFR10.31797247
135TAOK20.30653202
136RAF10.29558779
137LRRK20.28994507
138TXK0.27453481
139BCKDK0.25790346
140RPS6KB10.25237495

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.34095288
2Mismatch repair_Homo sapiens_hsa034303.85517727
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.78870902
4RNA polymerase_Homo sapiens_hsa030203.12966878
5RNA transport_Homo sapiens_hsa030133.11313406
6Cell cycle_Homo sapiens_hsa041103.06552957
7Spliceosome_Homo sapiens_hsa030402.85107174
8Base excision repair_Homo sapiens_hsa034102.82501784
9Nucleotide excision repair_Homo sapiens_hsa034202.63730553
10One carbon pool by folate_Homo sapiens_hsa006702.59854063
11Homologous recombination_Homo sapiens_hsa034402.59193703
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.37928449
13Proteasome_Homo sapiens_hsa030502.36092226
14Pyrimidine metabolism_Homo sapiens_hsa002402.26448900
15Fanconi anemia pathway_Homo sapiens_hsa034602.21347824
16Basal transcription factors_Homo sapiens_hsa030222.06314428
17p53 signaling pathway_Homo sapiens_hsa041151.98581499
18RNA degradation_Homo sapiens_hsa030181.85520987
19Non-homologous end-joining_Homo sapiens_hsa034501.77729713
20mRNA surveillance pathway_Homo sapiens_hsa030151.68962895
21Ribosome_Homo sapiens_hsa030101.52922979
22Vitamin B6 metabolism_Homo sapiens_hsa007501.49108457
23Selenocompound metabolism_Homo sapiens_hsa004501.38865283
24T cell receptor signaling pathway_Homo sapiens_hsa046601.35956453
25Epstein-Barr virus infection_Homo sapiens_hsa051691.27196579
26Purine metabolism_Homo sapiens_hsa002301.21872184
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18863796
28Herpes simplex infection_Homo sapiens_hsa051681.12163736
29Viral carcinogenesis_Homo sapiens_hsa052031.11511981
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11086123
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08746519
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.06690950
33Systemic lupus erythematosus_Homo sapiens_hsa053221.06164673
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.06036350
35Allograft rejection_Homo sapiens_hsa053301.04254676
36Biosynthesis of amino acids_Homo sapiens_hsa012301.02804751
37Pentose phosphate pathway_Homo sapiens_hsa000301.00583844
38B cell receptor signaling pathway_Homo sapiens_hsa046620.99016392
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96625200
40Folate biosynthesis_Homo sapiens_hsa007900.96409078
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91716932
42Antigen processing and presentation_Homo sapiens_hsa046120.91464930
43Graft-versus-host disease_Homo sapiens_hsa053320.91370460
44Autoimmune thyroid disease_Homo sapiens_hsa053200.88095683
45Small cell lung cancer_Homo sapiens_hsa052220.87922072
46Thyroid cancer_Homo sapiens_hsa052160.87403036
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86176089
48Oocyte meiosis_Homo sapiens_hsa041140.84822444
49MicroRNAs in cancer_Homo sapiens_hsa052060.82973394
50Legionellosis_Homo sapiens_hsa051340.82104553
51HTLV-I infection_Homo sapiens_hsa051660.80345350
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76521877
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75892112
54Hepatitis C_Homo sapiens_hsa051600.74185973
55Fatty acid elongation_Homo sapiens_hsa000620.72531036
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71296506
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71102261
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67858022
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67199755
60Steroid biosynthesis_Homo sapiens_hsa001000.66064990
61TGF-beta signaling pathway_Homo sapiens_hsa043500.63506929
62Measles_Homo sapiens_hsa051620.63308692
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.62387659
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60268597
65Osteoclast differentiation_Homo sapiens_hsa043800.59897637
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59567532
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57652956
68Chronic myeloid leukemia_Homo sapiens_hsa052200.57181713
69Hepatitis B_Homo sapiens_hsa051610.56366797
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56156783
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55567005
72Colorectal cancer_Homo sapiens_hsa052100.54661739
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.54549045
74Apoptosis_Homo sapiens_hsa042100.54199862
75Toxoplasmosis_Homo sapiens_hsa051450.50609970
76Influenza A_Homo sapiens_hsa051640.47674730
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47350184
78Protein export_Homo sapiens_hsa030600.46563542
79Type I diabetes mellitus_Homo sapiens_hsa049400.46350772
80Carbon metabolism_Homo sapiens_hsa012000.46024564
81Hippo signaling pathway_Homo sapiens_hsa043900.45385800
82Shigellosis_Homo sapiens_hsa051310.45365687
83Glutathione metabolism_Homo sapiens_hsa004800.44014454
84Tuberculosis_Homo sapiens_hsa051520.43973313
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41129115
86Renal cell carcinoma_Homo sapiens_hsa052110.40668084
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.40511018
88Salmonella infection_Homo sapiens_hsa051320.39362544
89Acute myeloid leukemia_Homo sapiens_hsa052210.39229007
90Endocytosis_Homo sapiens_hsa041440.38797603
91Leishmaniasis_Homo sapiens_hsa051400.38181298
92N-Glycan biosynthesis_Homo sapiens_hsa005100.37404065
93Pancreatic cancer_Homo sapiens_hsa052120.36669174
94Sulfur relay system_Homo sapiens_hsa041220.36324980
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35347060
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34721271
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.34198753
98Prostate cancer_Homo sapiens_hsa052150.32876902
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32264782
100Primary immunodeficiency_Homo sapiens_hsa053400.31603158
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.31160830
102Notch signaling pathway_Homo sapiens_hsa043300.31102411
103Bladder cancer_Homo sapiens_hsa052190.30858165
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30473099
105Regulation of autophagy_Homo sapiens_hsa041400.29298349
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28703312
107HIF-1 signaling pathway_Homo sapiens_hsa040660.28568132
108Galactose metabolism_Homo sapiens_hsa000520.28197099
109mTOR signaling pathway_Homo sapiens_hsa041500.27775285
110FoxO signaling pathway_Homo sapiens_hsa040680.27415361
111Pathways in cancer_Homo sapiens_hsa052000.26625858
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26245534
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24879509
114Endometrial cancer_Homo sapiens_hsa052130.23421041
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.23116484
116Non-small cell lung cancer_Homo sapiens_hsa052230.23108822
117Adherens junction_Homo sapiens_hsa045200.21640921
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20419700
119Fructose and mannose metabolism_Homo sapiens_hsa000510.20102000
120Lysine degradation_Homo sapiens_hsa003100.19727258
121TNF signaling pathway_Homo sapiens_hsa046680.19337239
122Hematopoietic cell lineage_Homo sapiens_hsa046400.18185363
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18010639
124Basal cell carcinoma_Homo sapiens_hsa052170.17948400
125Viral myocarditis_Homo sapiens_hsa054160.17038405
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.14997015

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