RNF40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)4.66975761
2Golgi transport vesicle coating (GO:0048200)4.66975761
3regulation of mammary gland epithelial cell proliferation (GO:0033599)4.52217154
4proline biosynthetic process (GO:0006561)4.42459219
5nuclear pore complex assembly (GO:0051292)4.18221153
6negative regulation of erythrocyte differentiation (GO:0045647)4.15670892
7positive regulation of histone deacetylation (GO:0031065)4.04923591
8nuclear pore organization (GO:0006999)3.83960804
9pre-miRNA processing (GO:0031054)3.80716558
10negative regulation of cell size (GO:0045792)3.70974129
11retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.70701179
12peptidyl-lysine dimethylation (GO:0018027)3.69595727
13heterochromatin organization (GO:0070828)3.66193636
143-UTR-mediated mRNA stabilization (GO:0070935)3.64896864
15protein localization to endosome (GO:0036010)3.59681760
16regulation of chromatin binding (GO:0035561)3.56760484
17protein retention in ER lumen (GO:0006621)3.51403653
18regulation of gamma-delta T cell differentiation (GO:0045586)3.39211031
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.33809547
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32539866
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.32384760
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32384760
23NLS-bearing protein import into nucleus (GO:0006607)3.31700841
24regulation of translational fidelity (GO:0006450)3.27855413
25negative regulation of histone methylation (GO:0031061)3.26513414
26regulation of histone H3-K9 methylation (GO:0051570)3.25398995
27gene silencing by RNA (GO:0031047)3.24721053
28regulation of nucleobase-containing compound transport (GO:0032239)3.24571943
29positive thymic T cell selection (GO:0045059)3.22833432
30synaptonemal complex assembly (GO:0007130)3.18355922
31gene silencing (GO:0016458)3.18097989
32pentose-phosphate shunt (GO:0006098)3.14457143
33cytoplasmic mRNA processing body assembly (GO:0033962)3.12325482
34basement membrane organization (GO:0071711)3.09284058
35peptidyl-arginine omega-N-methylation (GO:0035247)3.09035131
36antigen processing and presentation of endogenous antigen (GO:0019883)3.05842422
37RNA stabilization (GO:0043489)3.05651049
38mRNA stabilization (GO:0048255)3.05651049
39regulation of hippo signaling (GO:0035330)3.03560877
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.02696721
41regulation of translational termination (GO:0006449)3.01295371
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.00173776
43mitotic sister chromatid cohesion (GO:0007064)2.97139844
44regulation of early endosome to late endosome transport (GO:2000641)2.95830831
45mannose metabolic process (GO:0006013)2.95751807
46intracellular estrogen receptor signaling pathway (GO:0030520)2.95582422
47regulation of glucose import in response to insulin stimulus (GO:2001273)2.95092200
48mitotic chromosome condensation (GO:0007076)2.93055943
49maternal placenta development (GO:0001893)2.92833469
50positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.92061567
51chromosome condensation (GO:0030261)2.91794445
52activation of Rac GTPase activity (GO:0032863)2.91731532
53protein localization to kinetochore (GO:0034501)2.90622113
54protein localization to chromosome, centromeric region (GO:0071459)2.90567033
55pore complex assembly (GO:0046931)2.88568687
56synaptonemal complex organization (GO:0070193)2.87102517
57cellular protein complex localization (GO:0034629)2.87059012
58proline metabolic process (GO:0006560)2.86832360
59UV protection (GO:0009650)2.86065455
60regulation of RNA export from nucleus (GO:0046831)2.85081961
61mitotic nuclear envelope disassembly (GO:0007077)2.84409807
62positive regulation of protein deacetylation (GO:0090312)2.81735700
63positive regulation of gamma-delta T cell activation (GO:0046645)2.80315822
64nodal signaling pathway (GO:0038092)2.79822613
65modulation by virus of host process (GO:0019054)2.78968823
66thymic T cell selection (GO:0045061)2.78333282
67protein export from nucleus (GO:0006611)2.77339563
68protein complex localization (GO:0031503)2.77324413
69modulation by symbiont of host cellular process (GO:0044068)2.76143941
70dosage compensation (GO:0007549)2.76062003
71nuclear envelope disassembly (GO:0051081)2.76056025
72membrane disassembly (GO:0030397)2.76056025
73regulation of gamma-delta T cell activation (GO:0046643)2.75372127
74sister chromatid segregation (GO:0000819)2.74369787
75fusion of sperm to egg plasma membrane (GO:0007342)2.74055299
76coronary vasculature morphogenesis (GO:0060977)2.72827190
77regulation of fatty acid beta-oxidation (GO:0031998)2.72627256
78piRNA metabolic process (GO:0034587)2.72600069
79regulation of interleukin-12 biosynthetic process (GO:0045075)2.72272636
80regulation of centriole replication (GO:0046599)2.72067874
81chromatin silencing (GO:0006342)2.71820072
82semaphorin-plexin signaling pathway (GO:0071526)2.71534047
83snRNA metabolic process (GO:0016073)2.71379634
84chromatin assembly (GO:0031497)2.71275219
85glucose catabolic process (GO:0006007)2.71111046
86negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.69854674
87negative regulation of cell killing (GO:0031342)2.69854674
88regulation of NFAT protein import into nucleus (GO:0051532)2.66781204
89acrosome assembly (GO:0001675)2.66546651
90embryonic process involved in female pregnancy (GO:0060136)2.66404216
91histone mRNA catabolic process (GO:0071044)2.66350834
92GDP-mannose metabolic process (GO:0019673)2.66202834
93DNA packaging (GO:0006323)2.65889562
94glucose 6-phosphate metabolic process (GO:0051156)2.63874702
95folic acid metabolic process (GO:0046655)2.63624625
96nucleosome disassembly (GO:0006337)2.62222655
97protein-DNA complex disassembly (GO:0032986)2.62222655
98endothelial tube morphogenesis (GO:0061154)2.61812983
99morphogenesis of an endothelium (GO:0003159)2.61812983
100positive regulation of myotube differentiation (GO:0010831)2.61479144
101response to laminar fluid shear stress (GO:0034616)2.61264547
102epithelial cell differentiation involved in prostate gland development (GO:0060742)2.60324322
103regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.59719956
104lymph vessel development (GO:0001945)2.59476619
105cell-cell recognition (GO:0009988)2.59294487
106DNA topological change (GO:0006265)2.59093603
107male meiosis (GO:0007140)2.58272577
108sperm-egg recognition (GO:0035036)2.58218481
109adherens junction assembly (GO:0034333)2.57810162
110regulation of histone H3-K27 methylation (GO:0061085)2.57088442
111cellular response to epidermal growth factor stimulus (GO:0071364)2.56809628
112DNA replication initiation (GO:0006270)2.56698846
113NADPH regeneration (GO:0006740)2.56653535
114positive regulation of RNA splicing (GO:0033120)2.55756140
115cell-substrate junction assembly (GO:0007044)2.55213627
116mitotic sister chromatid segregation (GO:0000070)2.55052220
117histone H3-K9 demethylation (GO:0033169)2.54362501
118cell-substrate adherens junction assembly (GO:0007045)2.54309695
119focal adhesion assembly (GO:0048041)2.54309695
120negative regulation of myotube differentiation (GO:0010832)2.53654099
121histone H2A monoubiquitination (GO:0035518)2.52845186
122peptidyl-arginine methylation (GO:0018216)2.52597264
123peptidyl-arginine N-methylation (GO:0035246)2.52597264
124formation of translation preinitiation complex (GO:0001731)2.51285530
125DNA duplex unwinding (GO:0032508)2.51031571
126cytoskeletal anchoring at plasma membrane (GO:0007016)2.49444552
127antigen processing and presentation via MHC class Ib (GO:0002475)2.49209038
128regulation of nuclease activity (GO:0032069)2.48279797
129DNA geometric change (GO:0032392)2.47990903
130platelet formation (GO:0030220)2.47378858
131glucocorticoid receptor signaling pathway (GO:0042921)2.47292631
132stress granule assembly (GO:0034063)2.47049329
133positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.46376694
134histone H4 deacetylation (GO:0070933)2.45653969
135apoptotic process involved in morphogenesis (GO:0060561)2.44756314
136regulation of p38MAPK cascade (GO:1900744)2.44422289
137negative regulation of mRNA processing (GO:0050686)2.43132990
138DNA unwinding involved in DNA replication (GO:0006268)2.43042967
139negative regulation of mRNA metabolic process (GO:1903312)2.42235749
140response to UV-C (GO:0010225)2.41489991
141activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.40664934
142rRNA transcription (GO:0009303)2.39416799
143endoplasmic reticulum unfolded protein response (GO:0030968)2.39261320
144ribosomal small subunit biogenesis (GO:0042274)2.39126339
145negative regulation of fatty acid transport (GO:2000192)2.38696901
146regulation of cholesterol biosynthetic process (GO:0045540)2.38488381
147pinocytosis (GO:0006907)2.38486137
148mitotic G1 DNA damage checkpoint (GO:0031571)2.37880957
149trophectodermal cell differentiation (GO:0001829)2.37753386
150T cell selection (GO:0045058)2.37715902
151modulation by virus of host morphology or physiology (GO:0019048)2.37298596
152nuclear envelope organization (GO:0006998)2.37262292
153natural killer cell differentiation (GO:0001779)2.37217666
154binding of sperm to zona pellucida (GO:0007339)2.37124383
155macroautophagy (GO:0016236)2.36930280
156negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.36642613
157positive regulation of nuclease activity (GO:0032075)2.35884621
158regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.35797014
159positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.35797014
160regulation of cholesterol storage (GO:0010885)2.35678424
161folic acid-containing compound biosynthetic process (GO:0009396)2.35444716
162positive regulation of Cdc42 GTPase activity (GO:0043089)2.35364164
163negative regulation of striated muscle cell differentiation (GO:0051154)2.35207718
164negative regulation of viral release from host cell (GO:1902187)2.34805223
165plasma membrane repair (GO:0001778)2.34428769
166histone H3-K9 methylation (GO:0051567)2.33632154
167stress fiber assembly (GO:0043149)2.32338017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.58555616
2E2F7_22180533_ChIP-Seq_HELA_Human4.26223677
3MYC_22102868_ChIP-Seq_BL_Human3.84397788
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.48380520
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.03586784
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70277504
7TCF7_22412390_ChIP-Seq_EML_Mouse2.59970073
8VDR_21846776_ChIP-Seq_THP-1_Human2.48201977
9KDM2B_26808549_Chip-Seq_DND41_Human2.44675956
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33922464
11KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.27219713
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25334429
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.25149142
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.23442290
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05122655
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.02327266
17MAF_26560356_Chip-Seq_TH1_Human2.02003922
18UTX_26944678_Chip-Seq_JUKART_Human2.00270204
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94744231
20ZNF263_19887448_ChIP-Seq_K562_Human1.94087755
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91339763
22* XRN2_22483619_ChIP-Seq_HELA_Human1.83455785
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.82909359
24CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.80628370
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.77649882
26* LXR_22292898_ChIP-Seq_THP-1_Human1.76034597
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75542606
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71221287
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68383674
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63374469
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60021907
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.58411667
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58360961
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.55261544
35AR_21909140_ChIP-Seq_LNCAP_Human1.54843855
36KDM2B_26808549_Chip-Seq_JURKAT_Human1.54110020
37NCOR1_26117541_ChIP-Seq_K562_Human1.52351936
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50219152
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47736962
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46318620
41MYB_26560356_Chip-Seq_TH1_Human1.46261278
42RACK7_27058665_Chip-Seq_MCF-7_Human1.46103845
43* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45419269
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44106430
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41870015
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40088255
47CIITA_25753668_ChIP-Seq_RAJI_Human1.39535408
48CLOCK_20551151_ChIP-Seq_293T_Human1.37867921
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37787822
50ATF3_27146783_Chip-Seq_COLON_Human1.35999711
51MAF_26560356_Chip-Seq_TH2_Human1.35730580
52* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35557777
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35140205
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34153664
55MYB_26560356_Chip-Seq_TH2_Human1.32166088
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31877219
57VDR_24763502_ChIP-Seq_THP-1_Human1.31678767
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31639041
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31477701
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31018831
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30979523
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29089143
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28863895
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.28787719
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26364040
66P68_20966046_ChIP-Seq_HELA_Human1.25789817
67SMC4_20622854_ChIP-Seq_HELA_Human1.23989751
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23615236
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22188338
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21252738
71CREB1_26743006_Chip-Seq_LNCaP_Human1.21207086
72KDM2B_26808549_Chip-Seq_K562_Human1.20210438
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18905898
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18396100
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.17479273
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.16408567
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.15543204
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15372512
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14344816
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13977970
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12822141
82* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12680146
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.11400070
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11250548
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09257416
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08963046
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08912365
88SCL_19346495_ChIP-Seq_HPC-7_Human1.08734316
89SPI1_23127762_ChIP-Seq_K562_Human1.08363299
90BCOR_27268052_Chip-Seq_Bcells_Human1.08227694
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08005986
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07981270
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07273943
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07200140
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07077484
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06828515
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06691727
98PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06370999
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06366501
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06126185
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05689955
102GATA6_25053715_ChIP-Seq_YYC3_Human1.05508600
103CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05459788
104* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05126877
105E2F1_21310950_ChIP-Seq_MCF-7_Human1.04775926
106RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04677577
107TP53_22127205_ChIP-Seq_IMR90_Human1.02981286
108MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02637809
109RARA_24833708_ChIP-Seq_LIVER_Mouse1.02013975
110UBF1/2_26484160_Chip-Seq_HMECs_Human1.01983408
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01639137
112FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00658559
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00589521
114CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00481065
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99837019
116PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99808656
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.98625311
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.98625311
119MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98214400
120SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98100761
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97775667
122ESR2_21235772_ChIP-Seq_MCF-7_Human0.97587852
123SA1_27219007_Chip-Seq_ERYTHROID_Human0.97315914
124KDM5A_27292631_Chip-Seq_BREAST_Human0.97264745
125BCL6_27268052_Chip-Seq_Bcells_Human0.97112781
126RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96955754
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96676311
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96665458
129PHF8_20622854_ChIP-Seq_HELA_Human0.96029555
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95936134
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95378348
132GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93571098
133CHD1_26751641_Chip-Seq_LNCaP_Human0.91164924
134TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90744625
135IRF8_22096565_ChIP-ChIP_GC-B_Human0.90676571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.18570364
2MP0005076_abnormal_cell_differentiation2.91502757
3MP0010352_gastrointestinal_tract_polyps2.79594559
4MP0005451_abnormal_body_composition2.74981613
5MP0005058_abnormal_lysosome_morphology2.71089913
6MP0009278_abnormal_bone_marrow2.70646957
7MP0010234_abnormal_vibrissa_follicle2.56594331
8MP0005409_darkened_coat_color2.41720948
9MP0003300_gastrointestinal_ulcer2.37521251
10MP0008260_abnormal_autophagy2.26023539
11MP0010307_abnormal_tumor_latency2.23134049
12MP0004858_abnormal_nervous_system2.18971906
13MP0005410_abnormal_fertilization2.15008899
14MP0003303_peritoneal_inflammation2.12745299
15MP0003566_abnormal_cell_adhesion2.01454624
16MP0003111_abnormal_nucleus_morphology1.92018007
17MP0002249_abnormal_larynx_morphology1.90003124
18MP0008961_abnormal_basal_metabolism1.80722590
19MP0000678_abnormal_parathyroid_gland1.80687029
20MP0000733_abnormal_muscle_development1.80327701
21MP0004510_myositis1.79486644
22MP0004808_abnormal_hematopoietic_stem1.75482869
23MP0003693_abnormal_embryo_hatching1.73320614
24MP0008877_abnormal_DNA_methylation1.73119394
25MP0008438_abnormal_cutaneous_collagen1.68412570
26MP0001849_ear_inflammation1.63546478
27MP0001730_embryonic_growth_arrest1.63076430
28MP0000685_abnormal_immune_system1.61476451
29MP0005397_hematopoietic_system_phenotyp1.60140235
30MP0001545_abnormal_hematopoietic_system1.60140235
31MP0003172_abnormal_lysosome_physiology1.59164229
32MP0003077_abnormal_cell_cycle1.58220499
33MP0005501_abnormal_skin_physiology1.57761746
34MP0004185_abnormal_adipocyte_glucose1.50188220
35MP0002234_abnormal_pharynx_morphology1.49785289
36MP0005623_abnormal_meninges_morphology1.49434723
37MP0001346_abnormal_lacrimal_gland1.48763764
38MP0004197_abnormal_fetal_growth/weight/1.43205348
39MP0001348_abnormal_lacrimal_gland1.37060076
40MP0003984_embryonic_growth_retardation1.36589994
41MP0003763_abnormal_thymus_physiology1.35946848
42MP0002088_abnormal_embryonic_growth/wei1.35195234
43MP0004947_skin_inflammation1.34092545
44MP0005380_embryogenesis_phenotype1.33332801
45MP0001672_abnormal_embryogenesis/_devel1.33332801
46MP0003329_amyloid_beta_deposits1.31104640
47MP0000703_abnormal_thymus_morphology1.30663819
48MP0000350_abnormal_cell_proliferation1.29524748
49MP0004957_abnormal_blastocyst_morpholog1.29431838
50MP0002653_abnormal_ependyma_morphology1.29281969
51MP0005023_abnormal_wound_healing1.29039895
52MP0005257_abnormal_intraocular_pressure1.27499058
53MP0004036_abnormal_muscle_relaxation1.26488786
54MP0002086_abnormal_extraembryonic_tissu1.25076397
55MP0010094_abnormal_chromosome_stability1.23744994
56MP0002796_impaired_skin_barrier1.22942925
57MP0010630_abnormal_cardiac_muscle1.22566871
58MP0003191_abnormal_cellular_cholesterol1.22230000
59MP0005666_abnormal_adipose_tissue1.21460385
60MP0005621_abnormal_cell_physiology1.21244601
61MP0001929_abnormal_gametogenesis1.21213829
62MP0002084_abnormal_developmental_patter1.21195875
63MP0004233_abnormal_muscle_weight1.20973624
64MP0003091_abnormal_cell_migration1.20779069
65MP0002166_altered_tumor_susceptibility1.18548182
66MP0008932_abnormal_embryonic_tissue1.17477492
67MP0002254_reproductive_system_inflammat1.13284652
68MP0004087_abnormal_muscle_fiber1.12591763
69MP0002398_abnormal_bone_marrow1.11915526
70MP0005375_adipose_tissue_phenotype1.10456450
71MP0002080_prenatal_lethality1.10370320
72MP0002060_abnormal_skin_morphology1.09672967
73MP0005171_absent_coat_pigmentation1.09659177
74MP0001800_abnormal_humoral_immune1.09288411
75MP0001697_abnormal_embryo_size1.08582344
76MP0004084_abnormal_cardiac_muscle1.06298212
77MP0001873_stomach_inflammation1.04521907
78MP0002877_abnormal_melanocyte_morpholog1.01641246
79MP0002085_abnormal_embryonic_tissue1.00656739
80MP0002089_abnormal_postnatal_growth/wei0.98671737
81MP0002722_abnormal_immune_system0.97880013
82MP0003698_abnormal_male_reproductive0.97691505
83MP0003436_decreased_susceptibility_to0.97217412
84MP0003942_abnormal_urinary_system0.96834601
85MP0000747_muscle_weakness0.96077445
86MP0000681_abnormal_thyroid_gland0.95909832
87MP0003315_abnormal_perineum_morphology0.95514417
88MP0005384_cellular_phenotype0.93983946
89MP0005387_immune_system_phenotype0.93933047
90MP0001790_abnormal_immune_system0.93933047
91MP0009931_abnormal_skin_appearance0.93919228
92MP0002210_abnormal_sex_determination0.93431053
93MP0003656_abnormal_erythrocyte_physiolo0.92741120
94MP0002396_abnormal_hematopoietic_system0.92355367
95MP0004264_abnormal_extraembryonic_tissu0.92241998
96MP0002092_abnormal_eye_morphology0.92071285
97MP0003453_abnormal_keratinocyte_physiol0.92039069
98MP0002925_abnormal_cardiovascular_devel0.90993661
99MP0000003_abnormal_adipose_tissue0.90241137
100MP0000537_abnormal_urethra_morphology0.90165278
101MP0000490_abnormal_crypts_of0.89964941
102MP0004130_abnormal_muscle_cell0.89878084
103MP0009672_abnormal_birth_weight0.89376622
104MP0005670_abnormal_white_adipose0.89006038
105MP0009840_abnormal_foam_cell0.88687390
106MP0010155_abnormal_intestine_physiology0.87896591
107MP0000569_abnormal_digit_pigmentation0.87740687
108MP0009333_abnormal_splenocyte_physiolog0.87552553
109MP0003115_abnormal_respiratory_system0.87251692
110MP0000689_abnormal_spleen_morphology0.86754838
111MP0004782_abnormal_surfactant_physiolog0.84368838
112MP0003045_fibrosis0.84162732
113MP0008007_abnormal_cellular_replicative0.83877090
114MP0000266_abnormal_heart_morphology0.83763037
115MP0001661_extended_life_span0.83217397
116MP0002098_abnormal_vibrissa_morphology0.82378395
117MP0002019_abnormal_tumor_incidence0.82270389
118MP0001958_emphysema0.82192894
119MP0002009_preneoplasia0.81561344
120MP0000716_abnormal_immune_system0.80324692
121MP0001145_abnormal_male_reproductive0.79618935
122MP0001216_abnormal_epidermal_layer0.79356313
123MP0002452_abnormal_antigen_presenting0.79333221
124MP0000534_abnormal_ureter_morphology0.79332639
125MP0000313_abnormal_cell_death0.78717995
126MP0004381_abnormal_hair_follicle0.78314678
127MP0003123_paternal_imprinting0.78214327
128MP0000767_abnormal_smooth_muscle0.77955362
129MP0002429_abnormal_blood_cell0.77806552
130MP0004272_abnormal_basement_membrane0.77359534
131MP0002269_muscular_atrophy0.76570658
132MP0001915_intracranial_hemorrhage0.75514255
133MP0010030_abnormal_orbit_morphology0.75339715
134MP0000609_abnormal_liver_physiology0.75242875
135MP0008770_decreased_survivor_rate0.74502487
136MP0003221_abnormal_cardiomyocyte_apopto0.74201574
137MP0000477_abnormal_intestine_morphology0.74083432
138MP0002697_abnormal_eye_size0.73727689
139MP0003385_abnormal_body_wall0.73696535
140MP0001819_abnormal_immune_cell0.73505877
141MP0002420_abnormal_adaptive_immunity0.73131423
142MP0003866_abnormal_defecation0.72628181
143MP0009053_abnormal_anal_canal0.72559232
144MP0000858_altered_metastatic_potential0.72055488
145MP0002405_respiratory_system_inflammati0.71880005

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.93121234
2Nasal polyposis (HP:0100582)3.75947831
3Abnormality of the nasal mucosa (HP:0000433)3.40775718
4Cerebral aneurysm (HP:0004944)3.39410729
5Elfin facies (HP:0004428)3.05264564
6Abnormality of the lower motor neuron (HP:0002366)2.78409157
7Vertebral compression fractures (HP:0002953)2.75810358
8Renovascular hypertension (HP:0100817)2.74629800
9Broad distal phalanx of finger (HP:0009836)2.67560336
10Long palpebral fissure (HP:0000637)2.54179115
11Shallow orbits (HP:0000586)2.53242208
12Abnormality of the fingertips (HP:0001211)2.52269440
13Colitis (HP:0002583)2.51081605
14Difficulty climbing stairs (HP:0003551)2.47693384
15Renal duplication (HP:0000075)2.47505044
16Premature rupture of membranes (HP:0001788)2.46048082
17Insomnia (HP:0100785)2.43285466
18Broad face (HP:0000283)2.37625592
19Asymmetry of the thorax (HP:0001555)2.36978609
20Hand muscle atrophy (HP:0009130)2.36472994
21Disproportionate tall stature (HP:0001519)2.35369569
22Distal lower limb amyotrophy (HP:0008944)2.34468707
23Abnormality of the distal phalanx of the thumb (HP:0009617)2.34167151
24Overriding aorta (HP:0002623)2.33480792
25Ulnar bowing (HP:0003031)2.32793062
26Upper limb amyotrophy (HP:0009129)2.32061537
27Distal upper limb amyotrophy (HP:0007149)2.32061537
28Ependymoma (HP:0002888)2.31959789
29Short 4th metacarpal (HP:0010044)2.31308821
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.31308821
31Hemorrhage of the eye (HP:0011885)2.27929196
32Abnormality of the phalanges of the hallux (HP:0010057)2.22668488
33Abnormality of the distal phalanges of the toes (HP:0010182)2.21500990
34Verrucae (HP:0200043)2.21227642
35Papilloma (HP:0012740)2.21227642
36Heterotopia (HP:0002282)2.21208170
37Genu recurvatum (HP:0002816)2.19107872
38Aneurysm (HP:0002617)2.18073151
39Increased density of long bones (HP:0006392)2.17346345
40Turricephaly (HP:0000262)2.16520855
41Gastrointestinal inflammation (HP:0004386)2.16168104
42Recurrent bronchitis (HP:0002837)2.15630623
43Enlarged penis (HP:0000040)2.15497803
44Biconcave vertebral bodies (HP:0004586)2.15043025
45Obstructive sleep apnea (HP:0002870)2.14737113
46Mitral valve prolapse (HP:0001634)2.13782861
47Lymphangioma (HP:0100764)2.13365064
48Bronchitis (HP:0012387)2.13062099
49Increased connective tissue (HP:0009025)2.12204853
50Male infertility (HP:0003251)2.11975806
51Vertebral arch anomaly (HP:0008438)2.11233845
52Abnormality of the Achilles tendon (HP:0005109)2.09325372
53Chronic bronchitis (HP:0004469)2.09209313
54Abnormality of the 4th metacarpal (HP:0010012)2.06871636
55Subacute progressive viral hepatitis (HP:0006572)2.06788485
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.05191349
57Syringomyelia (HP:0003396)2.04366675
58Spinal cord lesions (HP:0100561)2.04366675
59High pitched voice (HP:0001620)2.03155701
60Bladder diverticulum (HP:0000015)2.02332295
61Cholecystitis (HP:0001082)2.01722172
62Abnormal gallbladder physiology (HP:0012438)2.01722172
63Inflammation of the large intestine (HP:0002037)2.01275692
64Frequent falls (HP:0002359)2.00252889
65Patellar dislocation (HP:0002999)2.00235396
66Asymmetric septal hypertrophy (HP:0001670)1.99053436
67Sparse lateral eyebrow (HP:0005338)1.97866120
68Dislocated radial head (HP:0003083)1.97764612
69Bowel diverticulosis (HP:0005222)1.97331084
70Recurrent viral infections (HP:0004429)1.96264194
71Abnormality of the thoracic spine (HP:0100711)1.95431745
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95375064
73High anterior hairline (HP:0009890)1.94677696
74Flat acetabular roof (HP:0003180)1.93596374
75Difficulty running (HP:0009046)1.93410244
76Deviation of the thumb (HP:0009603)1.93228508
77Reticulocytosis (HP:0001923)1.93178448
78Broad metatarsal (HP:0001783)1.92994776
79Germ cell neoplasia (HP:0100728)1.92922792
80Mitral regurgitation (HP:0001653)1.91645690
81Pseudobulbar signs (HP:0002200)1.91367031
82Viral hepatitis (HP:0006562)1.91292903
83Proximal placement of thumb (HP:0009623)1.91266946
84Metaphyseal cupping (HP:0003021)1.91014748
85Pointed chin (HP:0000307)1.90803780
86Rectal prolapse (HP:0002035)1.89783639
87Basal cell carcinoma (HP:0002671)1.89317828
88Increased nuchal translucency (HP:0010880)1.89181132
89Bowing of the arm (HP:0006488)1.88284821
90Bowed forearm bones (HP:0003956)1.88284821
91Short nail (HP:0001799)1.87612092
92Thin ribs (HP:0000883)1.87580407
93Progressive muscle weakness (HP:0003323)1.87345794
94Hypercortisolism (HP:0001578)1.86794689
95Abnormality of the radial head (HP:0003995)1.86595452
96Hyporeflexia of lower limbs (HP:0002600)1.85827048
97Selective tooth agenesis (HP:0001592)1.84191304
98Aortic aneurysm (HP:0004942)1.83455476
99Trismus (HP:0000211)1.82982744
100Ankle contracture (HP:0006466)1.82066641
101Macroorchidism (HP:0000053)1.82060704
102Hematochezia (HP:0002573)1.81606488
103Panhypogammaglobulinemia (HP:0003139)1.81542588
104Testicular atrophy (HP:0000029)1.81346286
105Truncus arteriosus (HP:0001660)1.81261618
106Long toe (HP:0010511)1.80659786
107Hallux valgus (HP:0001822)1.80400759
108Centrally nucleated skeletal muscle fibers (HP:0003687)1.79135516
109Hyperparathyroidism (HP:0000843)1.79033360
110Annular pancreas (HP:0001734)1.78738364
111Abnormality of the astrocytes (HP:0100707)1.77769969
112Astrocytoma (HP:0009592)1.77769969
113Deep palmar crease (HP:0006191)1.77660521
114Dysmetric saccades (HP:0000641)1.77266863
115Progressive external ophthalmoplegia (HP:0000590)1.76550474
116Recurrent fungal infections (HP:0002841)1.76093279
117EMG: neuropathic changes (HP:0003445)1.75900761
118Ragged-red muscle fibers (HP:0003200)1.75900444
119Missing ribs (HP:0000921)1.75515101
120Cerebral inclusion bodies (HP:0100314)1.75394723
121Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75216930
122Septate vagina (HP:0001153)1.75045091
123Cutaneous melanoma (HP:0012056)1.73439360
124Autoimmune thrombocytopenia (HP:0001973)1.72830680
125Abnormality of the gastric mucosa (HP:0004295)1.72375307
126Cholelithiasis (HP:0001081)1.72346118
127Deviation of the hallux (HP:0010051)1.72119223
128Right ventricular cardiomyopathy (HP:0011663)1.71202431
129Sandal gap (HP:0001852)1.71190669
130Premature skin wrinkling (HP:0100678)1.71134657
131Bicuspid aortic valve (HP:0001647)1.69939151
132Fibroma (HP:0010614)1.69286259
133Hypopigmentation of the fundus (HP:0007894)1.69081243
134Polycythemia (HP:0001901)1.68841124
135Atelectasis (HP:0100750)1.68249883
136Cellulitis (HP:0100658)1.67918299
137Intestinal fistula (HP:0100819)1.67773388
138Long eyelashes (HP:0000527)1.67548424
139Prominent nose (HP:0000448)1.67335020
140Abnormality of the peritoneum (HP:0002585)1.67183892
141Protrusio acetabuli (HP:0003179)1.66728962
142Flat cornea (HP:0007720)1.66532332
143Lower limb amyotrophy (HP:0007210)1.65929398
144Ankyloglossia (HP:0010296)1.65913991
145Pelvic girdle muscle weakness (HP:0003749)1.65195541
146Milia (HP:0001056)1.64252441
147Abnormality of the calcaneus (HP:0008364)1.64188306
148Fibrous tissue neoplasm (HP:0012316)1.63959619
149Resting tremor (HP:0002322)1.63852447
150Myopathic facies (HP:0002058)1.63600665
151Malignant gastrointestinal tract tumors (HP:0006749)1.63186556
152Gastrointestinal carcinoma (HP:0002672)1.63186556
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62673651
154Persistence of primary teeth (HP:0006335)1.62536490
155Flattened epiphyses (HP:0003071)1.62527236
156Nonimmune hydrops fetalis (HP:0001790)1.62366164
157Self-mutilation (HP:0000742)1.62362840
158Fragile skin (HP:0001030)1.62339842
159Bowel incontinence (HP:0002607)1.61559613
160Bundle branch block (HP:0011710)1.61108430
161Achilles tendon contracture (HP:0001771)1.61041960
162Abnormal large intestine physiology (HP:0012700)1.60708631
163Wormian bones (HP:0002645)1.60656752
164Spina bifida occulta (HP:0003298)1.60041710
165Dilatation of the ascending aorta (HP:0005111)1.59875281
166Broad palm (HP:0001169)1.59607521
167Vaginal fistula (HP:0004320)1.59425316
168Precocious puberty (HP:0000826)1.58555461
169Back pain (HP:0003418)1.58282905
170Neuronal loss in central nervous system (HP:0002529)1.58069217
171Abnormality of the gallbladder (HP:0005264)1.56659327
172Thin bony cortex (HP:0002753)1.56331552
173Cervical subluxation (HP:0003308)1.55487257
174Interstitial pulmonary disease (HP:0006530)1.55135847
175Deep venous thrombosis (HP:0002625)1.54054826
176Abnormality of the umbilical cord (HP:0010881)1.53517178
177Blue sclerae (HP:0000592)1.52791153

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.00119693
2PKN24.08875954
3SMG14.01283152
4EEF2K3.82036833
5MAP3K103.59421823
6PRPF4B3.01717564
7CDK122.87905596
8IRAK32.65623056
9TTN2.24129029
10ICK2.14445365
11NEK22.02354921
12MAP4K12.01672029
13ERN11.86360799
14PTK61.84990924
15PDK31.76720499
16PDK41.76720499
17NME21.74587657
18STK101.62029899
19RIPK11.58640315
20CAMK1G1.52087025
21TESK11.50970961
22CAMK1D1.37771881
23PRKD31.36228630
24FGFR41.31693850
25MTOR1.30627910
26SIK11.30507882
27PDGFRA1.29222203
28LRRK21.26567246
29GRK61.20689289
30TAOK21.19750821
31TAOK11.18101045
32ALK1.16488983
33RPS6KB21.13846506
34LMTK21.11728342
35CDK41.09098350
36MAP3K111.09048251
37RPS6KA41.07395662
38SIK21.07387949
39MARK21.04772281
40LATS11.00233504
41CDK70.99073425
42IRAK20.98003999
43SCYL20.97512704
44STK40.96680765
45CDC70.96342354
46STK380.95685677
47PRKD20.95512252
48BMX0.95494481
49TYRO30.94990573
50DYRK1B0.90623918
51TYK20.89029411
52CDK60.88468715
53PDPK10.87617886
54EPHB10.86310542
55PAK40.86115677
56MAP3K70.84657770
57MAP3K80.83141896
58RPS6KC10.81798853
59RPS6KL10.81798853
60PIM10.81192402
61TBK10.79864293
62JAK10.79699652
63MAP2K30.79124928
64PAK20.79058449
65STK30.78981856
66FGFR20.78904633
67ARAF0.78892275
68MAP3K10.76466133
69PDK20.75181124
70JAK30.74622042
71AURKA0.72304722
72MAP2K20.70643105
73PTK20.69998437
74DMPK0.69895224
75TTK0.68234064
76IRAK40.67229691
77MST1R0.66919247
78PIM20.65829722
79NTRK10.65199896
80ZAP700.64987504
81FGFR30.64781915
82CHUK0.63916960
83NEK10.63885636
84CHEK10.61266632
85ITK0.59956395
86BRAF0.59794874
87PASK0.59061897
88RPS6KA60.59037496
89FLT30.58623879
90CHEK20.58469988
91PDGFRB0.58078327
92MAPKAPK30.57471547
93BRD40.56789713
94RET0.55533610
95ILK0.54420073
96HIPK20.54150981
97AKT20.53914482
98HCK0.51204964
99CDC42BPA0.50345745
100CLK10.48455788
101CSK0.48169362
102CDK11A0.47762418
103MAPK150.47665973
104MARK30.46800200
105SIK30.46141830
106JAK20.45837483
107CDK150.45399863
108RPS6KA10.44097551
109EPHA20.44074225
110BTK0.43705260
111PDK10.43695556
112CDK20.42353154
113MAP3K140.41778087
114MAP3K60.41556236
115FRK0.39999652
116CAMKK10.39297559
117IKBKE0.39067186
118ATR0.38833565
119SRPK10.38637824
120TESK20.38525057
121BLK0.38346763
122RAF10.38322477
123RPS6KA20.38251573
124CDK180.38180243
125CDK80.37395591
126RIPK40.37201676
127CDK90.36762821
128CSNK1D0.36479157
129PTK2B0.36142252
130MAPK110.35587513
131FGFR10.34597836
132CDK10.34306236
133AURKB0.33684460
134SGK30.33411834
135KSR20.33211173
136PRKAA10.33054050
137LATS20.32355971
138PNCK0.32089802
139EGFR0.31977614
140MAP3K30.31902557
141MAP3K130.31580194
142DAPK30.30351526

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.09473064
2Chronic myeloid leukemia_Homo sapiens_hsa052201.99660675
3B cell receptor signaling pathway_Homo sapiens_hsa046621.87838592
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.85115515
5Lysine degradation_Homo sapiens_hsa003101.79661329
6DNA replication_Homo sapiens_hsa030301.73773078
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69864454
8Small cell lung cancer_Homo sapiens_hsa052221.62054704
9Sulfur relay system_Homo sapiens_hsa041221.60390223
10Fructose and mannose metabolism_Homo sapiens_hsa000511.59599765
11Insulin resistance_Homo sapiens_hsa049311.55053115
12Antigen processing and presentation_Homo sapiens_hsa046121.53791052
13Thyroid cancer_Homo sapiens_hsa052161.48898037
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.45508328
15mTOR signaling pathway_Homo sapiens_hsa041501.45330136
16Notch signaling pathway_Homo sapiens_hsa043301.42562991
17T cell receptor signaling pathway_Homo sapiens_hsa046601.39850965
18Acute myeloid leukemia_Homo sapiens_hsa052211.39290204
19Primary immunodeficiency_Homo sapiens_hsa053401.39035362
20VEGF signaling pathway_Homo sapiens_hsa043701.35541362
21Viral carcinogenesis_Homo sapiens_hsa052031.35050321
22mRNA surveillance pathway_Homo sapiens_hsa030151.31410712
23Viral myocarditis_Homo sapiens_hsa054161.28288352
24Non-small cell lung cancer_Homo sapiens_hsa052231.26792175
25ErbB signaling pathway_Homo sapiens_hsa040121.23379205
26HTLV-I infection_Homo sapiens_hsa051661.22369704
27Prion diseases_Homo sapiens_hsa050201.22072811
28MicroRNAs in cancer_Homo sapiens_hsa052061.21989855
29Glucagon signaling pathway_Homo sapiens_hsa049221.21713202
30Dorso-ventral axis formation_Homo sapiens_hsa043201.21703497
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20238517
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19473504
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.19034191
34Toxoplasmosis_Homo sapiens_hsa051451.18073992
35Osteoclast differentiation_Homo sapiens_hsa043801.17645593
36Proteoglycans in cancer_Homo sapiens_hsa052051.17042953
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16967623
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16569298
39Focal adhesion_Homo sapiens_hsa045101.15944292
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.15016146
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.14405662
42Prolactin signaling pathway_Homo sapiens_hsa049171.13907824
43Estrogen signaling pathway_Homo sapiens_hsa049151.13676432
44Selenocompound metabolism_Homo sapiens_hsa004501.12290185
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10920327
46Glioma_Homo sapiens_hsa052141.08916775
47Endometrial cancer_Homo sapiens_hsa052131.08096097
48Pancreatic cancer_Homo sapiens_hsa052121.07027950
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06182302
50Apoptosis_Homo sapiens_hsa042101.05485283
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04723839
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.04374522
53Herpes simplex infection_Homo sapiens_hsa051681.02195795
54Galactose metabolism_Homo sapiens_hsa000521.01741344
55Bladder cancer_Homo sapiens_hsa052191.01559127
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00842133
57Adherens junction_Homo sapiens_hsa045201.00283609
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00084878
59Fatty acid biosynthesis_Homo sapiens_hsa000610.97996027
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97423243
61RNA transport_Homo sapiens_hsa030130.97288562
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96701199
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96624171
64One carbon pool by folate_Homo sapiens_hsa006700.96286445
65AMPK signaling pathway_Homo sapiens_hsa041520.95019963
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93519784
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92936928
68Hepatitis C_Homo sapiens_hsa051600.92166503
69HIF-1 signaling pathway_Homo sapiens_hsa040660.92106309
70Inositol phosphate metabolism_Homo sapiens_hsa005620.91520689
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91383459
72Insulin signaling pathway_Homo sapiens_hsa049100.91169028
73PPAR signaling pathway_Homo sapiens_hsa033200.90989509
74Nitrogen metabolism_Homo sapiens_hsa009100.90058762
75Hepatitis B_Homo sapiens_hsa051610.89237165
76Type II diabetes mellitus_Homo sapiens_hsa049300.88807092
77p53 signaling pathway_Homo sapiens_hsa041150.87455657
78Leishmaniasis_Homo sapiens_hsa051400.86929949
79Choline metabolism in cancer_Homo sapiens_hsa052310.86019440
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.84162098
81Biosynthesis of amino acids_Homo sapiens_hsa012300.83767563
82Colorectal cancer_Homo sapiens_hsa052100.83155793
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.82273303
84Measles_Homo sapiens_hsa051620.80168358
85Amoebiasis_Homo sapiens_hsa051460.80095709
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79248366
87Prostate cancer_Homo sapiens_hsa052150.78718655
88Renal cell carcinoma_Homo sapiens_hsa052110.78703289
89Cell cycle_Homo sapiens_hsa041100.78188521
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78035180
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.77966572
92TNF signaling pathway_Homo sapiens_hsa046680.77863970
93Pentose phosphate pathway_Homo sapiens_hsa000300.77520708
94Vibrio cholerae infection_Homo sapiens_hsa051100.76965905
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.76357901
96FoxO signaling pathway_Homo sapiens_hsa040680.75330671
97Influenza A_Homo sapiens_hsa051640.74242705
98Epstein-Barr virus infection_Homo sapiens_hsa051690.72770268
99Platelet activation_Homo sapiens_hsa046110.72566923
100Fatty acid degradation_Homo sapiens_hsa000710.71948702
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71466715
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71318538
103GnRH signaling pathway_Homo sapiens_hsa049120.71311682
104Fat digestion and absorption_Homo sapiens_hsa049750.70737765
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68441193
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.68410121
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67456295
108Lysosome_Homo sapiens_hsa041420.67453776
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65851079
110Carbon metabolism_Homo sapiens_hsa012000.65447080
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65153918
112N-Glycan biosynthesis_Homo sapiens_hsa005100.64872587
113Base excision repair_Homo sapiens_hsa034100.63895183
114Glycerolipid metabolism_Homo sapiens_hsa005610.62200039
115Spliceosome_Homo sapiens_hsa030400.61088183
116Alcoholism_Homo sapiens_hsa050340.60675472
117Salmonella infection_Homo sapiens_hsa051320.60250306
118Melanoma_Homo sapiens_hsa052180.58788379
119Endocytosis_Homo sapiens_hsa041440.58787849
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58467250
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58417246
122Chemokine signaling pathway_Homo sapiens_hsa040620.57991903
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57703419
124Pathways in cancer_Homo sapiens_hsa052000.57388077
125Hippo signaling pathway_Homo sapiens_hsa043900.57159764
126Tight junction_Homo sapiens_hsa045300.57024438
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56853315
128Shigellosis_Homo sapiens_hsa051310.56339189
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55783373
130Legionellosis_Homo sapiens_hsa051340.55162948
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53817332
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53646668
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53043020

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