RNF43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.79095521
2L-phenylalanine catabolic process (GO:0006559)6.79095521
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.58940057
4L-phenylalanine metabolic process (GO:0006558)6.58940057
5aromatic amino acid family catabolic process (GO:0009074)5.79863545
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.62680124
7urea metabolic process (GO:0019627)5.25105662
8urea cycle (GO:0000050)5.25105662
9desmosome organization (GO:0002934)5.18862655
10sulfur amino acid catabolic process (GO:0000098)5.16213111
11alpha-linolenic acid metabolic process (GO:0036109)5.06628966
12bile acid biosynthetic process (GO:0006699)5.03994217
13kynurenine metabolic process (GO:0070189)5.00480994
14tryptophan catabolic process (GO:0006569)5.00052281
15indole-containing compound catabolic process (GO:0042436)5.00052281
16indolalkylamine catabolic process (GO:0046218)5.00052281
17high-density lipoprotein particle remodeling (GO:0034375)4.97819876
18cysteine metabolic process (GO:0006534)4.82546640
19protein carboxylation (GO:0018214)4.74681445
20peptidyl-glutamic acid carboxylation (GO:0017187)4.74681445
21glyoxylate metabolic process (GO:0046487)4.73010105
22nitrogen cycle metabolic process (GO:0071941)4.72568676
23tryptophan metabolic process (GO:0006568)4.69759789
24regulation of triglyceride catabolic process (GO:0010896)4.66484045
25bile acid metabolic process (GO:0008206)4.61545340
26intestinal cholesterol absorption (GO:0030299)4.58805347
27negative regulation of sterol transport (GO:0032372)4.58656816
28negative regulation of cholesterol transport (GO:0032375)4.58656816
29regulation of cholesterol esterification (GO:0010872)4.53189559
30negative regulation of fibrinolysis (GO:0051918)4.51429787
31reverse cholesterol transport (GO:0043691)4.49456380
32phospholipid efflux (GO:0033700)4.45816220
33homocysteine metabolic process (GO:0050667)4.44654180
34protein-lipid complex remodeling (GO:0034368)4.40141152
35macromolecular complex remodeling (GO:0034367)4.40141152
36plasma lipoprotein particle remodeling (GO:0034369)4.40141152
37regulation of protein activation cascade (GO:2000257)4.35561913
38regulation of fibrinolysis (GO:0051917)4.33411298
39bile acid and bile salt transport (GO:0015721)4.31617724
40complement activation, alternative pathway (GO:0006957)4.27875561
41serine family amino acid catabolic process (GO:0009071)4.26030653
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.23599434
43blood coagulation, intrinsic pathway (GO:0007597)4.23255858
44regulation of cholesterol homeostasis (GO:2000188)4.21318582
45amino-acid betaine metabolic process (GO:0006577)4.18816109
46regulation of bile acid biosynthetic process (GO:0070857)4.18270414
47acylglycerol homeostasis (GO:0055090)4.17367892
48triglyceride homeostasis (GO:0070328)4.17367892
49aromatic amino acid family metabolic process (GO:0009072)4.16431445
50bundle of His cell to Purkinje myocyte communication (GO:0086069)4.15220443
51cellular glucuronidation (GO:0052695)4.14987442
52plasma lipoprotein particle assembly (GO:0034377)4.11978713
53regulation of complement activation (GO:0030449)4.06881168
54cholesterol efflux (GO:0033344)3.97992745
55lysine metabolic process (GO:0006553)3.93922540
56lysine catabolic process (GO:0006554)3.93922540
57very-low-density lipoprotein particle assembly (GO:0034379)3.92486387
58tyrosine metabolic process (GO:0006570)3.90132783
59alpha-amino acid catabolic process (GO:1901606)3.88908717
60hepatocyte apoptotic process (GO:0097284)3.86318429
61low-density lipoprotein particle remodeling (GO:0034374)3.83278985
62ethanol oxidation (GO:0006069)3.82119900
63drug catabolic process (GO:0042737)3.78939908
64protein-lipid complex assembly (GO:0065005)3.76567619
65cholesterol homeostasis (GO:0042632)3.76181053
66imidazole-containing compound metabolic process (GO:0052803)3.76018918
67positive regulation of lipoprotein lipase activity (GO:0051006)3.73231628
68positive regulation of triglyceride lipase activity (GO:0061365)3.73231628
69cellular modified amino acid catabolic process (GO:0042219)3.71556822
70sterol homeostasis (GO:0055092)3.70003826
71plasma lipoprotein particle clearance (GO:0034381)3.69820673
72glycine metabolic process (GO:0006544)3.69763243
73intestinal absorption (GO:0050892)3.66287262
74cellular amino acid catabolic process (GO:0009063)3.64130413
75uronic acid metabolic process (GO:0006063)3.63353119
76glucuronate metabolic process (GO:0019585)3.63353119
77phospholipid scrambling (GO:0017121)3.60571297
78cellular ketone body metabolic process (GO:0046950)3.59995244
79glutamate metabolic process (GO:0006536)3.58367350
80branching involved in mammary gland duct morphogenesis (GO:0060444)3.57187085
81plasma lipoprotein particle organization (GO:0071827)3.54766838
82positive regulation of lipid catabolic process (GO:0050996)3.54237041
83serine family amino acid metabolic process (GO:0009069)3.54227451
84flavonoid metabolic process (GO:0009812)3.53402267
85phospholipid homeostasis (GO:0055091)3.53347813
86benzene-containing compound metabolic process (GO:0042537)3.52985571
87serine family amino acid biosynthetic process (GO:0009070)3.52387667
88negative regulation of lipase activity (GO:0060192)3.51182019
89striated muscle atrophy (GO:0014891)3.50815458
90coenzyme catabolic process (GO:0009109)3.49525616
91response to nitrosative stress (GO:0051409)3.48375697
92indolalkylamine metabolic process (GO:0006586)3.45793284
93fibrinolysis (GO:0042730)3.43714460
94lipoprotein metabolic process (GO:0042157)3.40679517
95ethanol metabolic process (GO:0006067)3.40347028
96amine catabolic process (GO:0009310)3.38826916
97cellular biogenic amine catabolic process (GO:0042402)3.38826916
98regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.37974002
99protein-lipid complex subunit organization (GO:0071825)3.37896646
100short-chain fatty acid metabolic process (GO:0046459)3.34145099
101regulation of cholesterol biosynthetic process (GO:0045540)3.32993298
102arginine metabolic process (GO:0006525)3.32173787
103drug transmembrane transport (GO:0006855)3.28887992
104positive regulation of fatty acid beta-oxidation (GO:0032000)3.26642819
105regulation of cholesterol metabolic process (GO:0090181)3.26524973
106negative regulation of protein activation cascade (GO:2000258)3.25573342
107positive regulation of Cdc42 GTPase activity (GO:0043089)3.22032936
108regulation of apoptotic cell clearance (GO:2000425)3.21956182
109positive regulation of triglyceride metabolic process (GO:0090208)3.18270156
110intestinal epithelial cell development (GO:0060576)3.17950367
111organic acid catabolic process (GO:0016054)3.17620616
112carboxylic acid catabolic process (GO:0046395)3.17620616
113endocardial cushion development (GO:0003197)3.16820034
114thrombin receptor signaling pathway (GO:0070493)3.13946247
115* receptor catabolic process (GO:0032801)3.10758866
116lung epithelium development (GO:0060428)3.04778463
117skeletal muscle adaptation (GO:0043501)3.02163947
118transepithelial transport (GO:0070633)3.01106959
119diacylglycerol metabolic process (GO:0046339)2.99289596
120proline metabolic process (GO:0006560)2.96659628
121low-density lipoprotein particle clearance (GO:0034383)2.88771101
122maintenance of gastrointestinal epithelium (GO:0030277)2.88485367
123proline biosynthetic process (GO:0006561)2.86904429
124muscle atrophy (GO:0014889)2.85783638
125negative regulation of myotube differentiation (GO:0010832)2.85287364
126negative regulation of complement activation (GO:0045916)2.84188604
127regulation of fatty acid beta-oxidation (GO:0031998)2.83792088
128positive regulation of steroid metabolic process (GO:0045940)2.78120458
129trivalent inorganic anion homeostasis (GO:0072506)2.77743395
130phosphate ion homeostasis (GO:0055062)2.77743395
131protein activation cascade (GO:0072376)2.71980363
132positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.70857968
133regulation of extracellular matrix organization (GO:1903053)2.69411238
134complement activation, classical pathway (GO:0006958)2.67823090
135negative regulation of sodium ion transport (GO:0010766)2.66100047
136regulation of humoral immune response (GO:0002920)2.64534674
137negative regulation of thymocyte apoptotic process (GO:0070244)2.64346968
138negative regulation of fatty acid transport (GO:2000192)2.61564094
139positive regulation of extracellular matrix organization (GO:1903055)2.59336296
140auditory receptor cell differentiation (GO:0042491)2.58471183
141positive regulation of hemostasis (GO:1900048)2.57741270
142positive regulation of blood coagulation (GO:0030194)2.57741270
143regulation of viral release from host cell (GO:1902186)2.57259411
144negative regulation of humoral immune response (GO:0002921)2.55514259
145positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.54879177
146regulation of water loss via skin (GO:0033561)2.54502786
147regulation of integrin activation (GO:0033623)2.53386958
148regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.51895580
149negative regulation of blood coagulation (GO:0030195)2.51348935
150negative regulation of hemostasis (GO:1900047)2.51348935
151renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.50423846
152inner ear receptor cell differentiation (GO:0060113)2.49700178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.51704945
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.82649722
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.18896834
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.51352353
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.27612965
6TP63_17297297_ChIP-ChIP_HaCaT_Human4.53837651
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.07261435
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.97834614
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.77296472
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.47577083
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.82082862
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.72582286
13SOX2_27498859_Chip-Seq_STOMACH_Mouse2.23346044
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18693201
15STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.02807411
16CDX2_20551321_ChIP-Seq_CACO-2_Human2.01688850
17CLOCK_20551151_ChIP-Seq_293T_Human1.92557231
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90379565
19* GATA4_25053715_ChIP-Seq_YYC3_Human1.83653673
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.79947406
21* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.78096971
22TCF7_22412390_ChIP-Seq_EML_Mouse1.76730800
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.73327598
24* FOXA2_19822575_ChIP-Seq_HepG2_Human1.71934938
25MYC_22102868_ChIP-Seq_BL_Human1.68812236
26ZNF263_19887448_ChIP-Seq_K562_Human1.58038042
27GATA1_22025678_ChIP-Seq_K562_Human1.56753928
28SCL_19346495_ChIP-Seq_HPC-7_Human1.56692221
29* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.51966965
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51027808
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.50363769
32* GATA1_19941827_ChIP-Seq_MEL_Mouse1.48023906
33* GATA6_25053715_ChIP-Seq_YYC3_Human1.47087145
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39451918
35* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37726954
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36640038
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33583935
38* SOX2_20726797_ChIP-Seq_SW620_Human1.33080463
39* HNF4A_19822575_ChIP-Seq_HepG2_Human1.32129165
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31269017
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.30875239
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30458447
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28348503
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26470851
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.26049716
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24735478
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.24573529
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22612619
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.21510890
50CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20021443
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19524921
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19212822
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.18945115
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15323647
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14927529
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13991132
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10329331
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10322614
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10036897
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09273671
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08993503
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08644080
63SPI1_23127762_ChIP-Seq_K562_Human1.07977589
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07859804
65AHR_22903824_ChIP-Seq_MCF-7_Human1.07711500
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07512208
67RACK7_27058665_Chip-Seq_MCF-7_Human1.06273299
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04695985
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04151777
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03290416
71UTX_26944678_Chip-Seq_JUKART_Human1.01442097
72AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01205938
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00530394
74* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00319255
75* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98631762
76* RUNX1_27514584_Chip-Seq_MCF-7_Human0.98391636
77* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96492393
78BCOR_27268052_Chip-Seq_Bcells_Human0.96377820
79GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96301487
80* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94940568
81FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94734730
82SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94267386
83VDR_21846776_ChIP-Seq_THP-1_Human0.94017886
84FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93732914
85MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93148066
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92907828
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90040842
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89512916
89* GATA3_24758297_ChIP-Seq_MCF-7_Human0.87900722
90* FOXA1_25552417_ChIP-Seq_VCAP_Human0.86864301
91* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83557137
92LXR_22292898_ChIP-Seq_THP-1_Human0.83263217
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83060825
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82577384
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82461945
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81693504
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79651643
98SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79651643
99TRIM28_21343339_ChIP-Seq_HEK293_Human0.79425936
100RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79360361
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78562471
102BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78163750
103GATA2_19941826_ChIP-Seq_K562_Human0.77302267
104* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.73336391
105* ATF3_27146783_Chip-Seq_COLON_Human0.73241179
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71380948
107CEBPB_22108803_ChIP-Seq_LS180_Human0.69800810
108* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.69659837
109HTT_18923047_ChIP-ChIP_STHdh_Human0.69585017
110FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.67427661
111RUNX_20019798_ChIP-Seq_JUKART_Human0.65633669
112* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.65129957
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.63981410
114EGR1_19032775_ChIP-ChIP_M12_Human0.63699910
115GATA1_19941826_ChIP-Seq_K562_Human0.63160914
116SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.61396096
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58771805
118NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58771805
119KLF5_25053715_ChIP-Seq_YYC3_Human0.58706172
120TP63_23658742_ChIP-Seq_EP156T_Human0.58539456
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.56407034
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.55422407
123CREB1_26743006_Chip-Seq_LNCaP_Human0.54787121
124* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.54215900
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.53685499
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.53398329
127NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.53189349
128CDX2_22108803_ChIP-Seq_LS180_Human0.53006772
129RARA_24833708_ChIP-Seq_LIVER_Mouse0.52740487
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.52450397
131NFIB_24661679_ChIP-Seq_LUNG_Mouse0.52214517
132STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.52040580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.92604749
2MP0005360_urolithiasis6.74437292
3MP0005085_abnormal_gallbladder_physiolo5.64335704
4MP0005365_abnormal_bile_salt5.31306044
5MP0008875_abnormal_xenobiotic_pharmacok4.50285269
6MP0001666_abnormal_nutrient_absorption3.48967119
7MP0003252_abnormal_bile_duct3.41787008
8MP0003806_abnormal_nucleotide_metabolis3.17916998
9MP0010329_abnormal_lipoprotein_level3.02981811
10MP0009840_abnormal_foam_cell2.87564954
11MP0003123_paternal_imprinting2.74407865
12MP0010234_abnormal_vibrissa_follicle2.73063932
13MP0005083_abnormal_biliary_tract2.72646596
14MP0002254_reproductive_system_inflammat2.24152086
15MP0003183_abnormal_peptide_metabolism2.19449076
16MP0004019_abnormal_vitamin_homeostasis2.15269674
17MP0005332_abnormal_amino_acid2.11985175
18MP0005409_darkened_coat_color2.05458947
19MP0005076_abnormal_cell_differentiation1.98838828
20MP0000609_abnormal_liver_physiology1.92863725
21MP0002138_abnormal_hepatobiliary_system1.89391179
22MP0003191_abnormal_cellular_cholesterol1.81002921
23MP0005058_abnormal_lysosome_morphology1.73258749
24MP0002118_abnormal_lipid_homeostasis1.71657839
25MP0003195_calcinosis1.71102903
26MP0003868_abnormal_feces_composition1.69871316
27MP0004264_abnormal_extraembryonic_tissu1.65429068
28MP0003705_abnormal_hypodermis_morpholog1.54923997
29MP0003300_gastrointestinal_ulcer1.51923958
30MP0002796_impaired_skin_barrier1.50922830
31MP0003172_abnormal_lysosome_physiology1.50374091
32MP0001765_abnormal_ion_homeostasis1.49160831
33MP0002089_abnormal_postnatal_growth/wei1.48073281
34MP0005319_abnormal_enzyme/_coenzyme1.45041759
35MP0005310_abnormal_salivary_gland1.41060138
36MP0003122_maternal_imprinting1.40342309
37MP0001664_abnormal_digestion1.38812438
38MP0010678_abnormal_skin_adnexa1.33554243
39MP0003453_abnormal_keratinocyte_physiol1.28814251
40MP0001873_stomach_inflammation1.28725497
41MP0005670_abnormal_white_adipose1.27926809
42MP0005451_abnormal_body_composition1.27676171
43MP0009643_abnormal_urine_homeostasis1.26830321
44MP0003943_abnormal_hepatobiliary_system1.25518749
45MP0004043_abnormal_pH_regulation1.22514513
46MP0000465_gastrointestinal_hemorrhage1.18596199
47MP0003566_abnormal_cell_adhesion1.18217379
48MP0004185_abnormal_adipocyte_glucose1.13310436
49MP0003656_abnormal_erythrocyte_physiolo1.11216120
50MP0009780_abnormal_chondrocyte_physiolo1.10943894
51MP0001764_abnormal_homeostasis1.10890331
52MP0005408_hypopigmentation1.10550828
53MP0002060_abnormal_skin_morphology1.10156754
54MP0002006_tumorigenesis1.07999332
55MP0003763_abnormal_thymus_physiology1.07798940
56MP0005584_abnormal_enzyme/coenzyme_acti1.07271311
57MP0000579_abnormal_nail_morphology1.06354962
58MP0000462_abnormal_digestive_system1.06349437
59MP0002098_abnormal_vibrissa_morphology1.05393748
60MP0010155_abnormal_intestine_physiology1.05312837
61MP0004947_skin_inflammation1.03435312
62MP0000383_abnormal_hair_follicle1.02599118
63MP0000858_altered_metastatic_potential1.02133163
64MP0005666_abnormal_adipose_tissue0.99821996
65MP0008961_abnormal_basal_metabolism0.99752493
66MP0000566_synostosis0.98309627
67MP0000598_abnormal_liver_morphology0.96395445
68MP0000490_abnormal_crypts_of0.95496951
69MP0001216_abnormal_epidermal_layer0.94858410
70MP0009764_decreased_sensitivity_to0.94362679
71MP0000537_abnormal_urethra_morphology0.92021338
72MP0005220_abnormal_exocrine_pancreas0.91991377
73MP0000678_abnormal_parathyroid_gland0.89921872
74MP0002009_preneoplasia0.88783163
75MP0009333_abnormal_splenocyte_physiolog0.87914660
76MP0004381_abnormal_hair_follicle0.87042066
77MP0004782_abnormal_surfactant_physiolog0.85932842
78MP0009763_increased_sensitivity_to0.85872527
79MP0003315_abnormal_perineum_morphology0.85052087
80MP0001849_ear_inflammation0.84927326
81MP0005647_abnormal_sex_gland0.84442423
82MP0002396_abnormal_hematopoietic_system0.84101877
83MP0001881_abnormal_mammary_gland0.83848792
84MP0005636_abnormal_mineral_homeostasis0.83755254
85MP0009053_abnormal_anal_canal0.83015675
86MP0005501_abnormal_skin_physiology0.81977679
87MP0000604_amyloidosis0.80719169
88MP0000377_abnormal_hair_follicle0.79546930
89MP0008469_abnormal_protein_level0.78736743
90MP0009697_abnormal_copulation0.78119245
91MP0005025_abnormal_response_to0.77416631
92MP0009765_abnormal_xenobiotic_induced0.77169859
93MP0001270_distended_abdomen0.76658080
94MP0009384_cardiac_valve_regurgitation0.76221283
95MP0003879_abnormal_hair_cell0.75337287
96MP0002132_abnormal_respiratory_system0.75258692
97MP0009115_abnormal_fat_cell0.74991399
98MP0001800_abnormal_humoral_immune0.74719918
99MP0003866_abnormal_defecation0.73734866
100MP0001663_abnormal_digestive_system0.73210384
101MP0003186_abnormal_redox_activity0.72214256
102MP0005381_digestive/alimentary_phenotyp0.71813527
103MP0002876_abnormal_thyroid_physiology0.70009919
104MP0005448_abnormal_energy_balance0.69929853
105MP0001835_abnormal_antigen_presentation0.69236932
106MP0002166_altered_tumor_susceptibility0.68019156
107MP0009642_abnormal_blood_homeostasis0.67616990
108MP0001346_abnormal_lacrimal_gland0.67113595
109MP0002086_abnormal_extraembryonic_tissu0.67103831
110MP0000470_abnormal_stomach_morphology0.66939915
111MP0005023_abnormal_wound_healing0.66848379
112MP0003011_delayed_dark_adaptation0.66832529
113MP0002970_abnormal_white_adipose0.65532373
114MP0000467_abnormal_esophagus_morphology0.65280292
115MP0002933_joint_inflammation0.64788600
116MP0000477_abnormal_intestine_morphology0.64008198
117MP0002136_abnormal_kidney_physiology0.63594999
118MP0000685_abnormal_immune_system0.62280105
119MP0000613_abnormal_salivary_gland0.61683777
120MP0001243_abnormal_dermal_layer0.59410428
121MP0005248_abnormal_Harderian_gland0.58633941
122MP0000647_abnormal_sebaceous_gland0.58539519
123MP0000538_abnormal_urinary_bladder0.58323172
124MP0000427_abnormal_hair_cycle0.58094193
125MP0008872_abnormal_physiological_respon0.57925889
126MP0001845_abnormal_inflammatory_respons0.56365251
127MP0010352_gastrointestinal_tract_polyps0.56352131
128MP0003638_abnormal_response/metabolism_0.56150320
129MP0009379_abnormal_foot_pigmentation0.55272037
130MP0010771_integument_phenotype0.54026293
131MP0005166_decreased_susceptibility_to0.53350126
132MP0008004_abnormal_stomach_pH0.51905411
133MP0005084_abnormal_gallbladder_morpholo0.51885882
134MP0009931_abnormal_skin_appearance0.49843024
135MP0001756_abnormal_urination0.49596912
136MP0003436_decreased_susceptibility_to0.48202513
137MP0003724_increased_susceptibility_to0.47462819
138MP0000627_abnormal_mammary_gland0.45434687
139MP0001853_heart_inflammation0.44972398
140MP0005464_abnormal_platelet_physiology0.44684966
141MP0006082_CNS_inflammation0.44463204

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.93018590
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.47940706
3Deep venous thrombosis (HP:0002625)6.42838187
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.17707266
5Hypobetalipoproteinemia (HP:0003563)5.76027393
6Xanthomatosis (HP:0000991)5.54800239
7Prolonged partial thromboplastin time (HP:0003645)5.36242475
8Prolonged bleeding time (HP:0003010)4.63386940
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.38130545
10Hyperlipoproteinemia (HP:0010980)4.30460392
11Fat malabsorption (HP:0002630)4.29810814
12Conjugated hyperbilirubinemia (HP:0002908)4.22596827
13Hypolipoproteinemia (HP:0010981)4.17028079
14Flat acetabular roof (HP:0003180)4.12566199
15Complement deficiency (HP:0004431)4.12501185
16Hyperammonemia (HP:0001987)4.11527417
17Purpura (HP:0000979)4.02625917
18Abnormality of the common coagulation pathway (HP:0010990)3.96736032
19Epidermoid cyst (HP:0200040)3.87789329
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.78209385
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.72960121
22Joint hemorrhage (HP:0005261)3.59213222
23Abnormal tarsal ossification (HP:0008369)3.58549000
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.51936891
25Hyperglycinemia (HP:0002154)3.50515228
26Ketosis (HP:0001946)3.45820036
27Abnormality of glycine metabolism (HP:0010895)3.44666437
28Abnormality of serine family amino acid metabolism (HP:0010894)3.44666437
29Hyperglycinuria (HP:0003108)3.43583995
30Hypoalphalipoproteinemia (HP:0003233)3.43054118
31Hypercholesterolemia (HP:0003124)3.36428231
32Ileus (HP:0002595)3.35734865
33Right ventricular cardiomyopathy (HP:0011663)3.32380198
34Abnormality of carpal bone ossification (HP:0006257)3.31786866
35Abnormality of methionine metabolism (HP:0010901)3.30340745
36Vascular calcification (HP:0004934)3.29331141
37Abnormality of the intrinsic pathway (HP:0010989)3.15292294
38Hypoglycemic coma (HP:0001325)3.12083729
39Hyperbilirubinemia (HP:0002904)3.11281901
40Steatorrhea (HP:0002570)3.09062181
41Abnormality of complement system (HP:0005339)3.04682527
42Myocardial infarction (HP:0001658)3.03140695
43Malnutrition (HP:0004395)3.01505926
44Abnormal platelet volume (HP:0011876)3.01153883
45Epistaxis (HP:0000421)2.96725503
46Hepatocellular carcinoma (HP:0001402)2.94684553
47Acanthocytosis (HP:0001927)2.91573514
48Cardiovascular calcification (HP:0011915)2.90971420
49Onycholysis (HP:0001806)2.86131142
50Abnormality of the gastric mucosa (HP:0004295)2.80373770
51Abnormality of pyrimidine metabolism (HP:0004353)2.76296091
52Abnormality of the nasal septum (HP:0000419)2.76059791
53Abnormality of nucleobase metabolism (HP:0010932)2.74951522
54Abnormality of fatty-acid metabolism (HP:0004359)2.74794298
55Abnormality of purine metabolism (HP:0004352)2.74279237
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.73720769
57Esophageal varix (HP:0002040)2.73350443
58Abnormal hand bone ossification (HP:0010660)2.67117943
59Abnormal ossification of hand bones (HP:0005921)2.62307652
60Abnormal foot bone ossification (HP:0010675)2.59837779
61Spastic diplegia (HP:0001264)2.57828940
62Abnormality of the fingertips (HP:0001211)2.51315501
63Small epiphyses (HP:0010585)2.49561220
64Gastrointestinal inflammation (HP:0004386)2.46279511
65Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.46107176
66Asymmetry of the thorax (HP:0001555)2.45841703
67Pigmentary retinal degeneration (HP:0001146)2.45540507
68Septate vagina (HP:0001153)2.44007113
69Inflammation of the large intestine (HP:0002037)2.43860476
70Hydroxyprolinuria (HP:0003080)2.42222091
71Abnormality of proline metabolism (HP:0010907)2.42222091
72Metabolic acidosis (HP:0001942)2.40856123
73Gout (HP:0001997)2.39376470
74Hyperactive renin-angiotensin system (HP:0000841)2.38651443
75Milia (HP:0001056)2.38448534
76Hypochromic microcytic anemia (HP:0004840)2.34428300
77Colitis (HP:0002583)2.33776608
78Widely patent fontanelles and sutures (HP:0004492)2.33380498
79Ketoacidosis (HP:0001993)2.32897483
80Abnormal gallbladder morphology (HP:0012437)2.30065712
81Cholelithiasis (HP:0001081)2.28909614
82Oligodontia (HP:0000677)2.23793331
83Abnormality of serum amino acid levels (HP:0003112)2.23068160
84Gingival bleeding (HP:0000225)2.21733948
85Cheilitis (HP:0100825)2.19958450
86Micronodular cirrhosis (HP:0001413)2.19589387
87Delayed CNS myelination (HP:0002188)2.18349705
88Petechiae (HP:0000967)2.17973988
89Spontaneous abortion (HP:0005268)2.17095539
90Pancreatitis (HP:0001733)2.15574453
91Pili torti (HP:0003777)2.14685469
92Amyloidosis (HP:0011034)2.11845075
93Poikilocytosis (HP:0004447)2.10520743
94Subacute progressive viral hepatitis (HP:0006572)2.08006154
95Plantar hyperkeratosis (HP:0007556)2.07997640
96Hemorrhage of the eye (HP:0011885)2.06126327
97Lethargy (HP:0001254)2.05497139
98Joint swelling (HP:0001386)2.03956900
99Seborrheic dermatitis (HP:0001051)2.01775736
100Broad alveolar ridges (HP:0000187)2.01570593
101Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01363485
102Dicarboxylic aciduria (HP:0003215)2.01363485
103Abnormality of transition element cation homeostasis (HP:0011030)2.01027029
104Abnormality of chloride homeostasis (HP:0011422)1.99820483
105Broad palm (HP:0001169)1.99671528
106Villous atrophy (HP:0011473)1.98923690
107Abnormality of small intestinal villus morphology (HP:0011472)1.98923690
108Rectal prolapse (HP:0002035)1.98028725
109Increased mean platelet volume (HP:0011877)1.97270370
110Pustule (HP:0200039)1.97155938
111Autoimmune hemolytic anemia (HP:0001890)1.96980188
112Rickets (HP:0002748)1.96802482
113Fragile nails (HP:0001808)1.96227560
114Impaired platelet aggregation (HP:0003540)1.96050102
115Abnormal platelet function (HP:0011869)1.96050102
116Amelogenesis imperfecta (HP:0000705)1.95859312
117Abdominal distention (HP:0003270)1.95837497
118Menorrhagia (HP:0000132)1.95653879
119Skin nodule (HP:0200036)1.92742234
120Abnormal hair laboratory examination (HP:0003328)1.91673452
121Decreased circulating renin level (HP:0003351)1.88794124
122Late onset (HP:0003584)1.88005114
123Abnormality of the gallbladder (HP:0005264)1.87008931
124Ridged nail (HP:0001807)1.86884392
125Recurrent gram-negative bacterial infections (HP:0005420)1.86525981
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86041006
127Curly hair (HP:0002212)1.85565171
128Hyponatremia (HP:0002902)1.84594177
129Renal cortical cysts (HP:0000803)1.83742903
130Chronic diarrhea (HP:0002028)1.82500935
131Atrophic scars (HP:0001075)1.81968800
132Abnormal gallbladder physiology (HP:0012438)1.80413610
133Cholecystitis (HP:0001082)1.80413610
134Irritability (HP:0000737)1.79884646
135Brushfield spots (HP:0001088)1.79658045
136Thrombophlebitis (HP:0004418)1.79087480
137Periodontitis (HP:0000704)1.78816298
138Opisthotonus (HP:0002179)1.78567021
139Hypoglycemic seizures (HP:0002173)1.77311779
140Abnormality of vitamin metabolism (HP:0100508)1.76738866
141Systemic lupus erythematosus (HP:0002725)1.76359358
142Gastrointestinal infarctions (HP:0005244)1.76040673
143Abnormal cartilage morphology (HP:0002763)1.75885487
144Ventricular fibrillation (HP:0001663)1.75804877
145Abnormality of iron homeostasis (HP:0011031)1.75175150
146Leiomyosarcoma (HP:0100243)1.75135257
147Uterine leiomyosarcoma (HP:0002891)1.75135257
148Hypophosphatemic rickets (HP:0004912)1.74270916
149Woolly hair (HP:0002224)1.74047430
150Glomerulonephritis (HP:0000099)1.73448767
151Epiphyseal dysplasia (HP:0002656)1.73383282
152Abnormality of renin-angiotensin system (HP:0000847)1.72977519
153Glomerulosclerosis (HP:0000096)1.72459683
154Renal cell carcinoma (HP:0005584)1.72057508
155Nephritis (HP:0000123)1.71677841
156Coarse hair (HP:0002208)1.71592140
157Reticulocytosis (HP:0001923)1.71113487
158Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69688526
159Neonatal death (HP:0003811)1.68577858
160Abnormality of the wing of the ilium (HP:0011867)1.68334024
161Gastrointestinal carcinoma (HP:0002672)1.68075983
162Malignant gastrointestinal tract tumors (HP:0006749)1.68075983

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK14.11416670
2EPHA23.44016100
3ERN13.40565586
4BCKDK3.39544146
5FGFR43.24819082
6MST1R2.91805420
7TAOK32.81396090
8FRK2.78980645
9LATS12.49050144
10MST42.41328532
11WNK42.39169421
12PTK62.35691229
13LMTK22.32843160
14EPHB12.19907767
15PKN21.89383191
16ICK1.82708683
17MAPK151.79990845
18TYK21.72961049
19MAP2K21.71603820
20TRIB31.65360254
21FGFR21.61238259
22NUAK11.54902231
23RIPK11.54580831
24MAPKAPK31.54324750
25MET1.41766015
26SMG11.41579793
27JAK11.40208077
28GRK61.39544178
29MAP4K11.37370602
30EEF2K1.36242985
31MAP3K101.36241518
32STK101.33848514
33MAP3K141.30510887
34STK391.25786696
35STK241.25134934
36ERBB21.24021424
37PTK21.23221108
38ERBB41.22813080
39MAP3K71.19772399
40ACVR1B1.16380839
41MAP3K31.14936676
42TBK11.12869963
43RIPK41.12734900
44LRRK21.12017786
45CDK61.09839522
46FER1.07181532
47MAP3K21.06878035
48CDC42BPA1.02011422
49MAP2K60.97898442
50MAPK110.97444998
51IKBKE0.95680952
52EPHA30.95583008
53JAK20.95045464
54INSRR0.93509400
55ITK0.92612236
56RPS6KB20.92156149
57DYRK1B0.88943366
58PRKG20.88894623
59CSK0.85914835
60PRKAA20.85243730
61AKT30.84673505
62TYRO30.82730375
63TNK20.82453970
64PDPK10.82232396
65IRAK30.77805082
66SCYL20.77614014
67CHUK0.76955602
68EPHB20.76543410
69CAMK1D0.75638456
70BMX0.74142930
71EIF2AK10.74141884
72ZAP700.71785023
73PRKCQ0.71120155
74PDK10.70714523
75MELK0.69529409
76JAK30.67373074
77GSK3A0.67071583
78PIK3CG0.62691511
79NEK90.61445977
80TESK20.60309210
81FGFR30.60249579
82NLK0.59873625
83DDR20.58302810
84PBK0.57959988
85STK30.57271178
86FGR0.56842023
87WNK10.55035252
88IRAK40.49519016
89TRPM70.48928031
90MAP2K10.48831365
91CSNK1A1L0.48800839
92TXK0.47953528
93CAMK2G0.46781746
94PDGFRB0.45991101
95CSNK1G10.45842564
96STK38L0.44985826
97MAP3K110.44855929
98PRKCI0.44293674
99CDK70.43215613
100MAP2K30.43169541
101PIK3CA0.42899115
102MARK20.42312198
103PRKAA10.42161427
104NEK60.41989131
105TAOK10.41314316
106HIPK20.39796103
107RPS6KB10.39727138
108FLT30.38624578
109GRK10.38116415
110MAP3K10.37585439
111PRKCZ0.36948742
112SYK0.36892092
113IKBKB0.36389360
114MAPKAPK20.33849576
115NME10.33246781
116YES10.33123370
117STK380.32963193
118CDK120.32874755
119PDGFRA0.32527590
120MTOR0.32509267
121BTK0.32377285
122MAPK40.32227288
123SIK20.31800086
124SGK30.31702655
125PAK40.31689501
126BMPR20.31505455
127TGFBR20.31369422
128KDR0.31147980
129FGFR10.30751432
130MATK0.30743642
131CDK40.30610429
132PRKD10.30121306
133CSF1R0.30095612
134MAP2K40.29070381
135OXSR10.29020259
136RET0.28734739
137CAMK1G0.26359967
138LCK0.25884224

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.04143742
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.75995781
3Nitrogen metabolism_Homo sapiens_hsa009103.70975067
4Arginine biosynthesis_Homo sapiens_hsa002202.79003286
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.69541460
6Tryptophan metabolism_Homo sapiens_hsa003802.54698485
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.47756364
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45064154
9Fatty acid degradation_Homo sapiens_hsa000712.41135302
10Histidine metabolism_Homo sapiens_hsa003402.30739169
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28911402
12Complement and coagulation cascades_Homo sapiens_hsa046102.28853703
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26872759
14Caffeine metabolism_Homo sapiens_hsa002322.25756793
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.25274459
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21283036
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.03666516
18Chemical carcinogenesis_Homo sapiens_hsa052042.00355766
19Other glycan degradation_Homo sapiens_hsa005111.99174571
20Fat digestion and absorption_Homo sapiens_hsa049751.95595634
21Sulfur metabolism_Homo sapiens_hsa009201.94038798
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.80688374
23Butanoate metabolism_Homo sapiens_hsa006501.77711409
24Peroxisome_Homo sapiens_hsa041461.76977126
25PPAR signaling pathway_Homo sapiens_hsa033201.74924028
26Retinol metabolism_Homo sapiens_hsa008301.71203475
27beta-Alanine metabolism_Homo sapiens_hsa004101.64317898
28Bile secretion_Homo sapiens_hsa049761.63854004
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.62561658
30Propanoate metabolism_Homo sapiens_hsa006401.59965287
31Fatty acid metabolism_Homo sapiens_hsa012121.59399296
32Platelet activation_Homo sapiens_hsa046111.46868957
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45886335
34Selenocompound metabolism_Homo sapiens_hsa004501.43622576
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42615567
36Staphylococcus aureus infection_Homo sapiens_hsa051501.40907201
37Folate biosynthesis_Homo sapiens_hsa007901.40801778
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.39186673
39ABC transporters_Homo sapiens_hsa020101.37776219
40Starch and sucrose metabolism_Homo sapiens_hsa005001.37502567
41Phenylalanine metabolism_Homo sapiens_hsa003601.30867631
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.30589313
43Endometrial cancer_Homo sapiens_hsa052131.22065415
44Pyruvate metabolism_Homo sapiens_hsa006201.21232184
45Non-small cell lung cancer_Homo sapiens_hsa052231.16702694
46Tyrosine metabolism_Homo sapiens_hsa003501.16032024
47Vitamin digestion and absorption_Homo sapiens_hsa049771.14796041
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13953870
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11480657
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10733440
51Fatty acid elongation_Homo sapiens_hsa000621.10379648
52Steroid biosynthesis_Homo sapiens_hsa001001.09159460
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.02688782
54Arginine and proline metabolism_Homo sapiens_hsa003301.00699660
55Sulfur relay system_Homo sapiens_hsa041221.00494973
56Biosynthesis of amino acids_Homo sapiens_hsa012300.99495779
57N-Glycan biosynthesis_Homo sapiens_hsa005100.98810262
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.97252794
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97012584
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95312782
61Choline metabolism in cancer_Homo sapiens_hsa052310.95050748
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91492871
63Thyroid cancer_Homo sapiens_hsa052160.90552774
64Carbon metabolism_Homo sapiens_hsa012000.90031768
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89762948
66Lysine degradation_Homo sapiens_hsa003100.89160838
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88326894
68Glycerolipid metabolism_Homo sapiens_hsa005610.85837613
69Glutathione metabolism_Homo sapiens_hsa004800.85106940
70Sphingolipid metabolism_Homo sapiens_hsa006000.73434801
71Pancreatic cancer_Homo sapiens_hsa052120.72438362
72Acute myeloid leukemia_Homo sapiens_hsa052210.72380295
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72159309
74B cell receptor signaling pathway_Homo sapiens_hsa046620.72107989
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72019086
76T cell receptor signaling pathway_Homo sapiens_hsa046600.70946312
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70805064
78Vitamin B6 metabolism_Homo sapiens_hsa007500.67046384
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65135630
80Pentose phosphate pathway_Homo sapiens_hsa000300.64072371
81Insulin signaling pathway_Homo sapiens_hsa049100.63520043
82Inositol phosphate metabolism_Homo sapiens_hsa005620.63032150
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59947122
84Fatty acid biosynthesis_Homo sapiens_hsa000610.59607359
85Chronic myeloid leukemia_Homo sapiens_hsa052200.59095791
86Notch signaling pathway_Homo sapiens_hsa043300.58740165
87One carbon pool by folate_Homo sapiens_hsa006700.56025005
88Hematopoietic cell lineage_Homo sapiens_hsa046400.54959758
89Glucagon signaling pathway_Homo sapiens_hsa049220.54874789
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54101995
91mTOR signaling pathway_Homo sapiens_hsa041500.53542696
92Linoleic acid metabolism_Homo sapiens_hsa005910.51283041
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51274353
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.49603955
95VEGF signaling pathway_Homo sapiens_hsa043700.46934476
96Vibrio cholerae infection_Homo sapiens_hsa051100.46678349
97Tight junction_Homo sapiens_hsa045300.45853034
98Galactose metabolism_Homo sapiens_hsa000520.44837875
99Endocytosis_Homo sapiens_hsa041440.42477080
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42240248
101ErbB signaling pathway_Homo sapiens_hsa040120.40194104
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37026076
103Insulin resistance_Homo sapiens_hsa049310.35330668
104Metabolic pathways_Homo sapiens_hsa011000.33939544
105FoxO signaling pathway_Homo sapiens_hsa040680.32835740
106Systemic lupus erythematosus_Homo sapiens_hsa053220.32308635
107Fructose and mannose metabolism_Homo sapiens_hsa000510.30595922
108Mineral absorption_Homo sapiens_hsa049780.30198390
109Protein digestion and absorption_Homo sapiens_hsa049740.29577036
110Renin-angiotensin system_Homo sapiens_hsa046140.25509117
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.20795110
112Hepatitis C_Homo sapiens_hsa051600.19476449
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.17191216
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.14125369
115Bladder cancer_Homo sapiens_hsa052190.12255318
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10411112
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06153909
118Arachidonic acid metabolism_Homo sapiens_hsa005900.04927910
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.03528834
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.03191964
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.03065742
122Thyroid hormone synthesis_Homo sapiens_hsa049180.02277475
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.01758288
124Adherens junction_Homo sapiens_hsa045200.01725457
125Amoebiasis_Homo sapiens_hsa051460.01299098
126Prion diseases_Homo sapiens_hsa050200.00228245
127Pancreatic secretion_Homo sapiens_hsa049720.00147244
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00038557
129Primary immunodeficiency_Homo sapiens_hsa05340-0.0681214
130Ether lipid metabolism_Homo sapiens_hsa00565-0.0566185
131Toxoplasmosis_Homo sapiens_hsa05145-0.0294301
132ECM-receptor interaction_Homo sapiens_hsa04512-0.0234032
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0224056
134AMPK signaling pathway_Homo sapiens_hsa04152-0.0146519
135Small cell lung cancer_Homo sapiens_hsa05222-0.0129117

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