RNF44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)6.41718579
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.65522310
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.57219081
4positive regulation of gamma-delta T cell activation (GO:0046645)5.54962092
5antigen processing and presentation of endogenous antigen (GO:0019883)5.33360643
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.18676943
7heterochromatin organization (GO:0070828)4.84085867
8leukocyte aggregation (GO:0070486)4.69380362
9regulation of posttranscriptional gene silencing (GO:0060147)4.59253346
10regulation of gene silencing by miRNA (GO:0060964)4.59253346
11regulation of gene silencing by RNA (GO:0060966)4.59253346
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.55133532
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.55133532
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.55133532
15modulation by symbiont of host immune response (GO:0052553)4.55133532
16positive regulation by symbiont of host defense response (GO:0052509)4.55133532
17modulation by symbiont of host defense response (GO:0052031)4.55133532
18regulation of gamma-delta T cell differentiation (GO:0045586)4.54728998
19regulation of gamma-delta T cell activation (GO:0046643)4.52463635
20negative thymic T cell selection (GO:0045060)4.44240779
21negative T cell selection (GO:0043383)4.30831276
22histone H4-K12 acetylation (GO:0043983)4.25863803
23intracellular estrogen receptor signaling pathway (GO:0030520)4.10012820
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.09484530
25T cell selection (GO:0045058)4.08799487
26detection of bacterium (GO:0016045)4.06854965
27positive T cell selection (GO:0043368)4.00771637
28detection of other organism (GO:0098543)3.99397001
29response to interleukin-15 (GO:0070672)3.91848136
30antigen processing and presentation via MHC class Ib (GO:0002475)3.88101000
31regulation of B cell receptor signaling pathway (GO:0050855)3.86968922
32negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.86834520
33positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.85081739
34histone H3-K36 demethylation (GO:0070544)3.84678992
35regulation of hippo signaling (GO:0035330)3.82686920
36negative regulation of histone methylation (GO:0031061)3.79944463
37histone H4-K5 acetylation (GO:0043981)3.77813172
38histone H4-K8 acetylation (GO:0043982)3.77813172
39regulation of NFAT protein import into nucleus (GO:0051532)3.72661886
40response to muramyl dipeptide (GO:0032495)3.70634570
41establishment of apical/basal cell polarity (GO:0035089)3.68490268
42paraxial mesoderm development (GO:0048339)3.59491576
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.58797849
44tolerance induction (GO:0002507)3.57687417
45peptidyl-lysine dimethylation (GO:0018027)3.54573140
46cytoskeletal anchoring at plasma membrane (GO:0007016)3.52739973
47histone H4-K16 acetylation (GO:0043984)3.52241031
48nodal signaling pathway (GO:0038092)3.52044746
49peptidyl-arginine omega-N-methylation (GO:0035247)3.50879136
50nucleosome disassembly (GO:0006337)3.45880747
51protein-DNA complex disassembly (GO:0032986)3.45880747
52neutrophil activation involved in immune response (GO:0002283)3.41987037
53mRNA stabilization (GO:0048255)3.41908928
54RNA stabilization (GO:0043489)3.41908928
55trophectodermal cell differentiation (GO:0001829)3.39342222
56macrophage activation involved in immune response (GO:0002281)3.38411721
57B cell receptor signaling pathway (GO:0050853)3.38116645
58NLS-bearing protein import into nucleus (GO:0006607)3.37469203
59regulation of B cell differentiation (GO:0045577)3.37189785
60regulation of translational fidelity (GO:0006450)3.36996799
61positive regulation of gene expression, epigenetic (GO:0045815)3.36412711
62positive regulation of histone deacetylation (GO:0031065)3.35050631
63positive regulation of B cell differentiation (GO:0045579)3.32503882
64glucocorticoid receptor signaling pathway (GO:0042921)3.32032857
65negative regulation of leukocyte mediated immunity (GO:0002704)3.31926104
66cellular extravasation (GO:0045123)3.31655157
67negative regulation of RNA splicing (GO:0033119)3.31629983
68peptidyl-arginine N-methylation (GO:0035246)3.31177778
69peptidyl-arginine methylation (GO:0018216)3.31177778
70negative regulation of mRNA processing (GO:0050686)3.29677995
71respiratory burst (GO:0045730)3.27831375
72natural killer cell differentiation (GO:0001779)3.27418379
73T cell migration (GO:0072678)3.26513430
74positive regulation of RNA splicing (GO:0033120)3.25404982
75negative regulation of cell size (GO:0045792)3.23179288
76response to peptidoglycan (GO:0032494)3.22639263
77negative regulation of glial cell proliferation (GO:0060253)3.22471783
78regulation of T cell tolerance induction (GO:0002664)3.21956905
79activated T cell proliferation (GO:0050798)3.21410462
80positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.21092744
81negative regulation of phagocytosis (GO:0050765)3.21080512
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.20735304
83Peyers patch development (GO:0048541)3.18273078
84mucosal-associated lymphoid tissue development (GO:0048537)3.18273078
85negative regulation of T cell mediated immunity (GO:0002710)3.17596571
86cellular response to interleukin-15 (GO:0071350)3.17231119
87apoptotic process involved in morphogenesis (GO:0060561)3.15342198
88positive regulation of SMAD protein import into nucleus (GO:0060391)3.15227642
89nuclear pore organization (GO:0006999)3.14766961
90negative regulation of mRNA metabolic process (GO:1903312)3.12985270
91embryonic foregut morphogenesis (GO:0048617)3.12434184
92polarized epithelial cell differentiation (GO:0030859)3.11667403
93nuclear pore complex assembly (GO:0051292)3.11075201
94gene silencing by RNA (GO:0031047)3.10110499
95regulation of histone H3-K27 methylation (GO:0061085)3.08508116
96gene silencing (GO:0016458)3.06006887
97modulation by virus of host process (GO:0019054)3.05955138
98dosage compensation (GO:0007549)3.05880665
99regulation of translational termination (GO:0006449)3.01748374
100mannose metabolic process (GO:0006013)2.99703257
101histone H2A monoubiquitination (GO:0035518)2.97854463
102regulation of chromatin binding (GO:0035561)2.97671743
103establishment of monopolar cell polarity (GO:0061162)2.97669117
104establishment or maintenance of monopolar cell polarity (GO:0061339)2.97669117
105adherens junction assembly (GO:0034333)2.97514320
106regulation of interferon-beta biosynthetic process (GO:0045357)2.97365023
107neutrophil activation (GO:0042119)2.96782949
108regulation of tolerance induction (GO:0002643)2.96171566
109regulation of ARF protein signal transduction (GO:0032012)2.95132478
110cytoplasmic mRNA processing body assembly (GO:0033962)2.94901453
111detection of external biotic stimulus (GO:0098581)2.92969497
112epithelial cell differentiation involved in prostate gland development (GO:0060742)2.90484787
113response to laminar fluid shear stress (GO:0034616)2.90273421
114regulation of myeloid leukocyte mediated immunity (GO:0002886)2.88202370
115regulation of RNA export from nucleus (GO:0046831)2.86340944
116DNA unwinding involved in DNA replication (GO:0006268)2.86213896
117regulation of leukocyte degranulation (GO:0043300)2.85860771
118regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.85821455
119positive regulation of Rap GTPase activity (GO:0032854)2.85331317
120stress granule assembly (GO:0034063)2.83984322
121T cell homeostasis (GO:0043029)2.82400605
122germinal center formation (GO:0002467)2.81534414
123histone lysine demethylation (GO:0070076)2.81349333
124mitotic G1 DNA damage checkpoint (GO:0031571)2.80979767
125establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.80715196
126positive regulation of granulocyte differentiation (GO:0030854)2.80663382
127negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.80284965
128negative regulation of cell killing (GO:0031342)2.80284965
129response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.79788107
130response to host immune response (GO:0052572)2.79788107
131histone H4 acetylation (GO:0043967)2.79787060
132regulation of T-helper 2 cell differentiation (GO:0045628)2.79588891
133histone H4 deacetylation (GO:0070933)2.78834818
134chromatin silencing (GO:0006342)2.78710649
135positive thymic T cell selection (GO:0045059)2.78660122
136immunoglobulin mediated immune response (GO:0016064)2.78520560
137regulation of glial cell proliferation (GO:0060251)2.77993296
138regulation of granulocyte differentiation (GO:0030852)2.77370613
139spliceosomal tri-snRNP complex assembly (GO:0000244)2.74794079
140regulation of mast cell degranulation (GO:0043304)2.74765089
141myeloid cell activation involved in immune response (GO:0002275)2.74147674
142regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.72979652
143regulation of ARF GTPase activity (GO:0032312)2.72934874
144histone H3-K4 methylation (GO:0051568)2.72877690
145establishment of nucleus localization (GO:0040023)2.71329105
146planar cell polarity pathway involved in neural tube closure (GO:0090179)2.71047699
147negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.70720468
148response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.70454086
149response to host (GO:0075136)2.70454086
150response to host defenses (GO:0052200)2.70454086
151regulation of early endosome to late endosome transport (GO:2000641)2.70097521
152regulation of mRNA stability (GO:0043488)2.69553034
153positive regulation of tolerance induction (GO:0002645)2.68987582
154cell-substrate adherens junction assembly (GO:0007045)2.68914248
155focal adhesion assembly (GO:0048041)2.68914248
156regulation of SMAD protein import into nucleus (GO:0060390)2.68437743
157detection of biotic stimulus (GO:0009595)2.67295886
158antigen receptor-mediated signaling pathway (GO:0050851)2.65856874
159histone arginine methylation (GO:0034969)2.64655660
160histone demethylation (GO:0016577)2.64123216
161hippo signaling (GO:0035329)2.62929335
162granulocyte activation (GO:0036230)2.62508009
163negative regulation of toll-like receptor signaling pathway (GO:0034122)2.62451556
164negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.61485290
165leukocyte migration involved in inflammatory response (GO:0002523)2.61352501
166negative regulation of innate immune response (GO:0045824)2.61013065
167mitotic G1/S transition checkpoint (GO:0044819)2.60210140
168leukocyte degranulation (GO:0043299)2.60145333
169signal complex assembly (GO:0007172)2.60068147
1703-UTR-mediated mRNA stabilization (GO:0070935)2.59711733
171NIK/NF-kappaB signaling (GO:0038061)2.59182775
172regulation of natural killer cell mediated immunity (GO:0002715)2.58647552
173regulation of histone H3-K9 methylation (GO:0051570)2.57846560
174negative regulation of gene expression, epigenetic (GO:0045814)2.55915186
175gastrulation with mouth forming second (GO:0001702)2.55491885
176anterior/posterior axis specification, embryo (GO:0008595)2.54793036
177alternative mRNA splicing, via spliceosome (GO:0000380)2.53691162
178thymic T cell selection (GO:0045061)2.53176479
179maternal placenta development (GO:0001893)2.52303869
180regulation of stem cell maintenance (GO:2000036)2.51901053
181establishment or maintenance of apical/basal cell polarity (GO:0035088)2.51879733
182establishment or maintenance of bipolar cell polarity (GO:0061245)2.51879733
183chromatin assembly (GO:0031497)2.51352320
184corticosteroid receptor signaling pathway (GO:0031958)2.51243104
185regulation of RNA stability (GO:0043487)2.49150946
186layer formation in cerebral cortex (GO:0021819)2.48312460
187negative regulation of erythrocyte differentiation (GO:0045647)2.47537606
188neural tube closure (GO:0001843)2.46318931
189internal peptidyl-lysine acetylation (GO:0018393)2.45172393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYC_22102868_ChIP-Seq_BL_Human3.83174228
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14864785
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.13537015
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.82006331
5KDM2B_26808549_Chip-Seq_DND41_Human2.77055776
6E2F7_22180533_ChIP-Seq_HELA_Human2.69043960
7ZFP281_18757296_ChIP-ChIP_E14_Mouse2.63513109
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.55510058
9* TCF7_22412390_ChIP-Seq_EML_Mouse2.54193106
10* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.53155189
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.50915715
12VDR_21846776_ChIP-Seq_THP-1_Human2.47231973
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.45652563
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.39152044
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.37639922
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.33338910
17ZFP281_27345836_Chip-Seq_ESCs_Mouse2.33056953
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.26164707
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.22637126
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.21242607
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.21242607
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.21242607
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.12742593
24ELK3_25401928_ChIP-Seq_HUVEC_Human2.10246078
25* LXR_22292898_ChIP-Seq_THP-1_Human2.04336808
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.95196315
27KDM2B_26808549_Chip-Seq_K562_Human1.94867258
28* RUNX1_22412390_ChIP-Seq_EML_Mouse1.88581936
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.84637620
30KDM2B_26808549_Chip-Seq_JURKAT_Human1.84279930
31RUNX_20019798_ChIP-Seq_JUKART_Human1.78263306
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.77891033
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.76293360
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76035278
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74213939
36ZNF263_19887448_ChIP-Seq_K562_Human1.72071575
37* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68892068
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65920889
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.64696985
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64036432
41* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62570249
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61991508
43* MYB_26560356_Chip-Seq_TH1_Human1.61924368
44* RACK7_27058665_Chip-Seq_MCF-7_Human1.60972333
45* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.60710552
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59627906
47* MYB_26560356_Chip-Seq_TH2_Human1.58878235
48* UTX_26944678_Chip-Seq_JUKART_Human1.58845017
49* MAF_26560356_Chip-Seq_TH1_Human1.53174383
50* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49367406
51* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48997228
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47909973
53P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47568155
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.47152216
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46291044
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45132599
57SPI1_23547873_ChIP-Seq_NB4_Human1.44444904
58CREB1_26743006_Chip-Seq_LNCaP_Human1.43949947
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42926827
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39256619
61* NCOR1_26117541_ChIP-Seq_K562_Human1.37843058
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37244571
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36002584
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34177943
65* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34173885
66NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.33807779
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32673171
68NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.32480831
69POU5F1_16518401_ChIP-PET_MESCs_Mouse1.31682827
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.31372546
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30919889
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.30817079
73P68_20966046_ChIP-Seq_HELA_Human1.30802600
74BCOR_27268052_Chip-Seq_Bcells_Human1.29619046
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29017123
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.28839909
77* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28760475
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28646596
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28303285
80* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28056361
81CIITA_25753668_ChIP-Seq_RAJI_Human1.26579627
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25223324
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24341398
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.23099185
85BCL6_27268052_Chip-Seq_Bcells_Human1.22692796
86IRF8_21731497_ChIP-ChIP_J774_Mouse1.22563853
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22528112
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.21750433
89* ATF3_27146783_Chip-Seq_COLON_Human1.21662712
90SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.20341548
91* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20183432
92* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20171581
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.19597570
94* RARB_27405468_Chip-Seq_BRAIN_Mouse1.18559900
95IRF8_27001747_Chip-Seq_BMDM_Mouse1.18346596
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18287338
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17954400
98TP53_22127205_ChIP-Seq_IMR90_Human1.17790006
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17713814
100STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16399633
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16107119
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15768649
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15710747
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.15394672
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14011081
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13749817
107TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12926246
108CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12015129
109VDR_24763502_ChIP-Seq_THP-1_Human1.12002779
110CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11887239
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.11586252
112* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11245914
113TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10601172
114ELF1_20517297_ChIP-Seq_JURKAT_Human1.09072905
115* MAF_26560356_Chip-Seq_TH2_Human1.09065720
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08315921
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08196270
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07369512
119* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07345892
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05979318
121SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05303525
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03533830
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03120616
124PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02571343
125* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01933674
126ERG_21242973_ChIP-ChIP_JURKAT_Human1.00595866
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00313770
128SMC4_20622854_ChIP-Seq_HELA_Human1.00152699
129GATA1_19941826_ChIP-Seq_K562_Human1.00055018
130SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00054008
131CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99887302
132SCL_19346495_ChIP-Seq_HPC-7_Human0.99293016
133SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99155182
134PHF8_20622854_ChIP-Seq_HELA_Human0.99129279
135* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99047540
136TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98951498
137MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98815284
138* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98017175
139CLOCK_20551151_ChIP-Seq_293T_Human0.97892101
140SPI1_23127762_ChIP-Seq_K562_Human0.97521047
141CTCF_27219007_Chip-Seq_Bcells_Human0.97489947
142SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96802426
143NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96694526
144GATA3_27048872_Chip-Seq_THYMUS_Human0.96481713
145* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96148371
146ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96077101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.09448711
2MP0005076_abnormal_cell_differentiation3.29283970
3MP0008961_abnormal_basal_metabolism3.23500449
4MP0003763_abnormal_thymus_physiology3.21778622
5MP0002653_abnormal_ependyma_morphology3.06241169
6MP0003705_abnormal_hypodermis_morpholog2.96252775
7MP0003724_increased_susceptibility_to2.93328586
8MP0005671_abnormal_response_to2.82915637
9MP0001835_abnormal_antigen_presentation2.78188590
10MP0009278_abnormal_bone_marrow2.65937422
11MP0001800_abnormal_humoral_immune2.65701179
12MP0010352_gastrointestinal_tract_polyps2.57422730
13MP0000685_abnormal_immune_system2.44503367
14MP0001849_ear_inflammation2.37518398
15MP0005025_abnormal_response_to2.33008954
16MP0005000_abnormal_immune_tolerance2.32774295
17MP0002420_abnormal_adaptive_immunity2.31964089
18MP0002419_abnormal_innate_immunity2.30840847
19MP0010030_abnormal_orbit_morphology2.30664257
20MP0001819_abnormal_immune_cell2.30068469
21MP0000537_abnormal_urethra_morphology2.26748242
22MP0003890_abnormal_embryonic-extraembry2.22866339
23MP0003283_abnormal_digestive_organ2.21521585
24MP0001730_embryonic_growth_arrest2.21325557
25MP0003119_abnormal_digestive_system2.21088739
26MP0005387_immune_system_phenotype2.20646517
27MP0001790_abnormal_immune_system2.20646517
28MP0002723_abnormal_immune_serum2.20460799
29MP0009333_abnormal_splenocyte_physiolog2.19514073
30MP0002452_abnormal_antigen_presenting2.07277742
31MP0002084_abnormal_developmental_patter2.06218868
32MP0005451_abnormal_body_composition2.04487865
33MP0008260_abnormal_autophagy1.99042310
34MP0010234_abnormal_vibrissa_follicle1.98242290
35MP0003172_abnormal_lysosome_physiology1.96427999
36MP0004197_abnormal_fetal_growth/weight/1.96354818
37MP0005623_abnormal_meninges_morphology1.95821216
38MP0000716_abnormal_immune_system1.94191245
39MP0003303_peritoneal_inflammation1.86816083
40MP0004381_abnormal_hair_follicle1.84943258
41MP0002405_respiratory_system_inflammati1.83041615
42MP0005380_embryogenesis_phenotype1.82549340
43MP0001672_abnormal_embryogenesis/_devel1.82549340
44MP0001873_stomach_inflammation1.81215913
45MP0002085_abnormal_embryonic_tissue1.79903139
46MP0003984_embryonic_growth_retardation1.78391637
47MP0005377_hearing/vestibular/ear_phenot1.78215153
48MP0003878_abnormal_ear_physiology1.78215153
49MP0002088_abnormal_embryonic_growth/wei1.76040424
50MP0004859_abnormal_synaptic_plasticity1.75765940
51MP0002086_abnormal_extraembryonic_tissu1.75725376
52MP0003866_abnormal_defecation1.69598618
53MP0000350_abnormal_cell_proliferation1.68791809
54MP0000689_abnormal_spleen_morphology1.66642390
55MP0001697_abnormal_embryo_size1.66442656
56MP0004957_abnormal_blastocyst_morpholog1.65608258
57MP0004133_heterotaxia1.64410988
58MP0009053_abnormal_anal_canal1.63807065
59MP0003300_gastrointestinal_ulcer1.63203341
60MP0002429_abnormal_blood_cell1.60712874
61MP0010155_abnormal_intestine_physiology1.59529990
62MP0003111_abnormal_nucleus_morphology1.58679027
63MP0004264_abnormal_extraembryonic_tissu1.58480600
64MP0004185_abnormal_adipocyte_glucose1.58007417
65MP0003566_abnormal_cell_adhesion1.57142624
66MP0001533_abnormal_skeleton_physiology1.56893100
67MP0008877_abnormal_DNA_methylation1.54767017
68MP0003123_paternal_imprinting1.54672087
69MP0002132_abnormal_respiratory_system1.53368337
70MP0005464_abnormal_platelet_physiology1.51088702
71MP0002009_preneoplasia1.42350343
72MP0008057_abnormal_DNA_replication1.41264265
73MP0003077_abnormal_cell_cycle1.40934899
74MP0009785_altered_susceptibility_to1.37806524
75MP0003121_genomic_imprinting1.36737655
76MP0002080_prenatal_lethality1.36056245
77MP0008995_early_reproductive_senescence1.33805199
78MP0003115_abnormal_respiratory_system1.32797383
79MP0004233_abnormal_muscle_weight1.32699451
80MP0000733_abnormal_muscle_development1.32405315
81MP0002925_abnormal_cardiovascular_devel1.32074375
82MP0001851_eye_inflammation1.31720722
83MP0002254_reproductive_system_inflammat1.30895152
84MP0000490_abnormal_crypts_of1.29627823
85MP0000858_altered_metastatic_potential1.28760189
86MP0003122_maternal_imprinting1.28718929
87MP0003861_abnormal_nervous_system1.25854300
88MP0004808_abnormal_hematopoietic_stem1.23580155
89MP0005409_darkened_coat_color1.21507968
90MP0005310_abnormal_salivary_gland1.19080340
91MP0008770_decreased_survivor_rate1.19058641
92MP0002234_abnormal_pharynx_morphology1.18146969
93MP0000678_abnormal_parathyroid_gland1.16755869
94MP0003828_pulmonary_edema1.16210353
95MP0006082_CNS_inflammation1.15818269
96MP0003567_abnormal_fetal_cardiomyocyte1.15264650
97MP0002166_altered_tumor_susceptibility1.14836239
98MP0003091_abnormal_cell_migration1.12941283
99MP0009672_abnormal_birth_weight1.10915388
100MP0005666_abnormal_adipose_tissue1.10663384
101MP0001845_abnormal_inflammatory_respons1.10661239
102MP0010630_abnormal_cardiac_muscle1.09799333
103MP0005397_hematopoietic_system_phenotyp1.09676877
104MP0001545_abnormal_hematopoietic_system1.09676877
105MP0004510_myositis1.09473735
106MP0004858_abnormal_nervous_system1.09425441
107MP0002998_abnormal_bone_remodeling1.09112714
108MP0001293_anophthalmia1.07193310
109MP0003183_abnormal_peptide_metabolism1.06435387
110MP0000703_abnormal_thymus_morphology1.03460161
111MP0000534_abnormal_ureter_morphology1.03210348
112MP0010094_abnormal_chromosome_stability1.03207648
113MP0003191_abnormal_cellular_cholesterol1.02338723
114MP0005375_adipose_tissue_phenotype1.02298867
115MP0009703_decreased_birth_body1.01189232
116MP0000428_abnormal_craniofacial_morphol1.00889547
117MP0002933_joint_inflammation0.99371342
118MP0002092_abnormal_eye_morphology0.98655368
119MP0002148_abnormal_hypersensitivity_rea0.97811044
120MP0003935_abnormal_craniofacial_develop0.97234399
121MP0000569_abnormal_digit_pigmentation0.96166998
122MP0001348_abnormal_lacrimal_gland0.96055797
123MP0002249_abnormal_larynx_morphology0.95221263
124MP0010307_abnormal_tumor_latency0.94342244
125MP0001915_intracranial_hemorrhage0.92356563
126MP0002697_abnormal_eye_size0.92212805
127MP0000266_abnormal_heart_morphology0.90698606
128MP0000313_abnormal_cell_death0.87131918
129MP0001784_abnormal_fluid_regulation0.86809459
130MP0002796_impaired_skin_barrier0.86549016
131MP0005023_abnormal_wound_healing0.83731200
132MP0000465_gastrointestinal_hemorrhage0.83220248
133MP0002396_abnormal_hematopoietic_system0.81796826
134MP0002277_abnormal_respiratory_mucosa0.80221469
135MP0002089_abnormal_postnatal_growth/wei0.80142843
136MP0008469_abnormal_protein_level0.79194860
137MP0000003_abnormal_adipose_tissue0.77674387
138MP0005167_abnormal_blood-brain_barrier0.77024161
139MP0002822_catalepsy0.75999790
140MP0002398_abnormal_bone_marrow0.75497169
141MP0003690_abnormal_glial_cell0.75095089
142MP0002932_abnormal_joint_morphology0.74305511
143MP0001663_abnormal_digestive_system0.74223840
144MP0005058_abnormal_lysosome_morphology0.73775210
145MP0004885_abnormal_endolymph0.73405116
146MP0001853_heart_inflammation0.73120105
147MP0004947_skin_inflammation0.71446973
148MP0005621_abnormal_cell_physiology0.70383636
149MP0000467_abnormal_esophagus_morphology0.69791651
150MP0002111_abnormal_tail_morphology0.69706721
151MP0002152_abnormal_brain_morphology0.69648415
152MP0002019_abnormal_tumor_incidence0.69137344
153MP0005187_abnormal_penis_morphology0.67902650
154MP0000477_abnormal_intestine_morphology0.67532407
155MP0003453_abnormal_keratinocyte_physiol0.66486798
156MP0000432_abnormal_head_morphology0.65204566
157MP0004130_abnormal_muscle_cell0.64837432
158MP0005670_abnormal_white_adipose0.64758076
159MP0008569_lethality_at_weaning0.64647208
160MP0002722_abnormal_immune_system0.64381836
161MP0002081_perinatal_lethality0.64321205
162MP0005390_skeleton_phenotype0.63536742
163MP0005501_abnormal_skin_physiology0.61943594
164MP0004811_abnormal_neuron_physiology0.61888964
165MP0009931_abnormal_skin_appearance0.59008481
166MP0002006_tumorigenesis0.54952506
167MP0005075_abnormal_melanosome_morpholog0.54592267

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.67085620
2Recurrent abscess formation (HP:0002722)4.13680879
3Recurrent bacterial skin infections (HP:0005406)4.09153691
4Ependymoma (HP:0002888)3.97486778
5Myositis (HP:0100614)3.86013677
6Hyperacusis (HP:0010780)3.78553456
7Abnormality of the lower motor neuron (HP:0002366)3.72005037
8Increased IgE level (HP:0003212)3.64310975
9Abnormality of macrophages (HP:0004311)3.62526920
10Elevated erythrocyte sedimentation rate (HP:0003565)3.60158314
11Meningitis (HP:0001287)3.49736053
12Obstructive lung disease (HP:0006536)3.38180083
13Chronic obstructive pulmonary disease (HP:0006510)3.38180083
14Panhypogammaglobulinemia (HP:0003139)3.31259170
15Pustule (HP:0200039)3.28692859
16Recurrent fungal infections (HP:0002841)3.28528283
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.24810090
18Gastrointestinal infarctions (HP:0005244)3.22964884
19Obstructive sleep apnea (HP:0002870)3.14476971
20Orchitis (HP:0100796)3.14250364
21Cellulitis (HP:0100658)3.14217062
22Abnormality of the astrocytes (HP:0100707)3.12980232
23Astrocytoma (HP:0009592)3.12980232
24Spontaneous hematomas (HP:0007420)3.03119172
25Annular pancreas (HP:0001734)3.00885500
26Stomatitis (HP:0010280)2.99017498
27Mediastinal lymphadenopathy (HP:0100721)2.98642314
28Recurrent gram-negative bacterial infections (HP:0005420)2.98458486
29Renal duplication (HP:0000075)2.97638223
30Gastrointestinal inflammation (HP:0004386)2.97577276
31Prolonged bleeding time (HP:0003010)2.92033057
32Optic neuritis (HP:0100653)2.91306026
33Retrobulbar optic neuritis (HP:0100654)2.91306026
34Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.91249409
35Encephalitis (HP:0002383)2.83710518
36Hypochromic anemia (HP:0001931)2.83240793
37Neoplasm of the heart (HP:0100544)2.80452750
38Pseudobulbar signs (HP:0002200)2.74296403
39Recurrent skin infections (HP:0001581)2.72558513
40Gingivitis (HP:0000230)2.72221623
41Inflammation of the large intestine (HP:0002037)2.70152096
42Colitis (HP:0002583)2.69642091
43Upper limb amyotrophy (HP:0009129)2.67925079
44Distal upper limb amyotrophy (HP:0007149)2.67925079
45Rib fusion (HP:0000902)2.61689248
46T lymphocytopenia (HP:0005403)2.61528351
47Metaphyseal cupping (HP:0003021)2.60679824
48Abnormality of the fingertips (HP:0001211)2.59736936
49Pointed chin (HP:0000307)2.59555876
50Chronic mucocutaneous candidiasis (HP:0002728)2.56171852
51Recurrent cutaneous fungal infections (HP:0011370)2.56171852
52Insomnia (HP:0100785)2.54808649
53Heterotopia (HP:0002282)2.54625528
54Macroorchidism (HP:0000053)2.52853774
55Cerebral aneurysm (HP:0004944)2.52548830
56Vasculitis (HP:0002633)2.50678666
57Slow saccadic eye movements (HP:0000514)2.50202362
58Recurrent viral infections (HP:0004429)2.48116017
59Urethral obstruction (HP:0000796)2.47667881
60Chest pain (HP:0100749)2.46422121
61Elfin facies (HP:0004428)2.45989491
62Lymphopenia (HP:0001888)2.43971036
63Ankyloglossia (HP:0010296)2.43295497
64Long eyelashes (HP:0000527)2.42666977
65Hand muscle atrophy (HP:0009130)2.41116981
66Short 4th metacarpal (HP:0010044)2.37279713
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.37279713
68Seborrheic dermatitis (HP:0001051)2.36645042
69Increased nuchal translucency (HP:0010880)2.36633913
70Urticaria (HP:0001025)2.36451654
71Segmental peripheral demyelination/remyelination (HP:0003481)2.34286630
72Agammaglobulinemia (HP:0004432)2.34148459
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.32991119
74Broad face (HP:0000283)2.31607046
75Hypochromic microcytic anemia (HP:0004840)2.30467565
76Polygenic inheritance (HP:0010982)2.29063075
77Trigonocephaly (HP:0000243)2.28284062
78Amyotrophic lateral sclerosis (HP:0007354)2.25700049
79Abnormality of T cell number (HP:0011839)2.25075341
80Basal cell carcinoma (HP:0002671)2.23097528
81Obsessive-compulsive behavior (HP:0000722)2.21695981
82Verrucae (HP:0200043)2.21472715
83Papilloma (HP:0012740)2.21472715
84Neoplasm of striated muscle (HP:0009728)2.20980339
85Abnormality of T cells (HP:0002843)2.20319592
86Shallow orbits (HP:0000586)2.20193115
87Deep palmar crease (HP:0006191)2.17923169
88Keratoconjunctivitis sicca (HP:0001097)2.16453057
89Neoplasm of the oral cavity (HP:0100649)2.15864606
90Skin tags (HP:0010609)2.14526404
91Viral hepatitis (HP:0006562)2.13835461
92Proximal placement of thumb (HP:0009623)2.13339281
93Overriding aorta (HP:0002623)2.13143699
94Broad palm (HP:0001169)2.11838878
95Epistaxis (HP:0000421)2.11613359
96Papilledema (HP:0001085)2.10942562
97Deviation of the thumb (HP:0009603)2.10332883
98Supernumerary ribs (HP:0005815)2.09467111
99Abnormality of oral frenula (HP:0000190)2.09304899
100Broad thumb (HP:0011304)2.08267854
101Vertebral fusion (HP:0002948)2.07835153
102Nasal polyposis (HP:0100582)2.05356635
103Glioma (HP:0009733)2.05183203
104Renovascular hypertension (HP:0100817)2.04576761
105Granulocytopenia (HP:0001913)2.04336862
106Abnormal number of incisors (HP:0011064)2.02063295
107Short phalanx of the thumb (HP:0009660)2.01933764
108Medulloblastoma (HP:0002885)1.99864653
109Arterial thrombosis (HP:0004420)1.99121810
110Gastrointestinal carcinoma (HP:0002672)1.98597243
111Malignant gastrointestinal tract tumors (HP:0006749)1.98597243
112Disproportionate tall stature (HP:0001519)1.97931680
113Abnormality of the columella (HP:0009929)1.97791466
114Pulmonary embolism (HP:0002204)1.97386597
115Dysmetric saccades (HP:0000641)1.97364760
116Easy fatigability (HP:0003388)1.96820095
117Sepsis (HP:0100806)1.96408097
118Anal stenosis (HP:0002025)1.94476035
119Chronic otitis media (HP:0000389)1.94260969
120Gastrointestinal stroma tumor (HP:0100723)1.93839020
121Osteomyelitis (HP:0002754)1.93332829
122Abnormality of the 4th metacarpal (HP:0010012)1.92680970
123Leukocytosis (HP:0001974)1.91959450
124Attention deficit hyperactivity disorder (HP:0007018)1.90701456
125Increased IgM level (HP:0003496)1.89572561
126Keratoconjunctivitis (HP:0001096)1.87638530
127Preauricular skin tag (HP:0000384)1.86162882
128Subacute progressive viral hepatitis (HP:0006572)1.85844809
129Difficulty running (HP:0009046)1.85306714
130Hemorrhage of the eye (HP:0011885)1.84872463
131Rectal prolapse (HP:0002035)1.84677811
132Shawl scrotum (HP:0000049)1.83788882
133Resting tremor (HP:0002322)1.83216635
134Aplasia/Hypoplasia of the thymus (HP:0010515)1.82465769
135Selective tooth agenesis (HP:0001592)1.81748029
136Lymphangioma (HP:0100764)1.81201772
137Ulnar bowing (HP:0003031)1.80199053
138Fibroma (HP:0010614)1.80142612
139Bowel incontinence (HP:0002607)1.79802543
140Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.79142420
141Short 1st metacarpal (HP:0010034)1.79142420
142Neonatal hypoglycemia (HP:0001998)1.78304974
143Microcytic anemia (HP:0001935)1.77023778
144IgM deficiency (HP:0002850)1.77020085
145Peripheral hypomyelination (HP:0007182)1.76130253
146Vertebral arch anomaly (HP:0008438)1.75578824
147Hypertensive crisis (HP:0100735)1.75466452
148Esophageal atresia (HP:0002032)1.75107719
149Hemoptysis (HP:0002105)1.74548639
150Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74379848
151Long palpebral fissure (HP:0000637)1.74178449
152Fibrous tissue neoplasm (HP:0012316)1.72945412
153Skin ulcer (HP:0200042)1.72870576
154Premature loss of primary teeth (HP:0006323)1.72374176
155Arnold-Chiari malformation (HP:0002308)1.72084189
156Episodic fever (HP:0001954)1.72074438
157Spina bifida occulta (HP:0003298)1.71939570
158Genu recurvatum (HP:0002816)1.71832692
159Aneurysm (HP:0002617)1.71652184
160Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71306670
161Bilateral microphthalmos (HP:0007633)1.70932371
162Anorexia (HP:0002039)1.70477859
163Cutis marmorata (HP:0000965)1.70330970
164Hypergammaglobulinemia (HP:0010702)1.68775856
165Missing ribs (HP:0000921)1.67665237
166Abnormality of the musculature of the hand (HP:0001421)1.67117067
167Abnormality of the aortic arch (HP:0012303)1.64857704
168Supernumerary bones of the axial skeleton (HP:0009144)1.64703034
169Adenoma sebaceum (HP:0009720)1.63907142
170Angiofibromas (HP:0010615)1.63907142
171Abnormality of T cell physiology (HP:0011840)1.63876776
172Uterine leiomyosarcoma (HP:0002891)1.63289888
173Leiomyosarcoma (HP:0100243)1.63289888
174Turricephaly (HP:0000262)1.62700456
175Pulmonary infiltrates (HP:0002113)1.62685420
176Vertebral clefting (HP:0008428)1.62387953
177Generalized hypotonia (HP:0001290)1.62165486
178Back pain (HP:0003418)1.62110965
179Narrow palate (HP:0000189)1.61627184
180Short humerus (HP:0005792)1.60789248
181Bicuspid aortic valve (HP:0001647)1.60534344
182Abnormality of the diencephalon (HP:0010662)1.60119668
183Megalocornea (HP:0000485)1.60004757
184Dislocated radial head (HP:0003083)1.59913332
185Mitral valve prolapse (HP:0001634)1.59810211
186Prominent nose (HP:0000448)1.59700918
187Skull defect (HP:0001362)1.59235675
188Apathy (HP:0000741)1.58769937
189Intestinal fistula (HP:0100819)1.58042090
190Large earlobe (HP:0009748)1.57479315
191Sacral dimple (HP:0000960)1.56964297
192Broad phalanges of the hand (HP:0009768)1.55545462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.42215053
2PRPF4B3.46855514
3EEF2K3.42880767
4MAP3K103.34799432
5ICK3.29966897
6RIPK43.29887838
7TRIB32.99794100
8SMG12.83975377
9TYRO32.52757440
10PKN22.39709070
11ERN12.27081605
12BRD42.18591244
13MAP3K92.12721710
14TNK21.88148796
15FES1.80804726
16SIK21.80573279
17MAP2K31.79204549
18IRAK41.75231554
19MAP3K131.72257084
20PRKD31.67446703
21ALK1.65018328
22TYK21.57927063
23RIPK11.56224751
24BLK1.52288953
25BTK1.50685918
26CAMK1G1.48718179
27MTOR1.45672216
28KSR21.43697836
29BMX1.43245676
30MAP4K11.39047745
31PDGFRA1.35486596
32PAK41.34539561
33PTK61.34213618
34GRK61.31929714
35STK101.28860675
36JAK31.26189303
37CAMK1D1.22085288
38TAOK11.18046412
39NEK21.16074380
40LRRK21.12560031
41KSR11.12002843
42CDK41.04762321
43LATS21.02939039
44RPS6KB21.00915044
45MAP3K10.99517692
46TXK0.99212006
47PAK60.98105305
48SYK0.97178227
49PTK20.95583579
50CDK70.95526450
51CDC70.94560881
52FGR0.92539108
53FGFR40.91152992
54MAP3K70.90861134
55SIK10.90571239
56EPHB20.90242872
57CDK60.89574155
58LCK0.88155166
59DMPK0.86925490
60PDK10.86227244
61FGFR10.85984494
62UHMK10.85115727
63RET0.83120515
64IKBKE0.81445847
65MAP3K140.80984059
66MAP3K30.79923216
67MARK20.78256069
68EPHB10.77976195
69SIK30.77790052
70JAK20.77425360
71EPHA20.76807393
72RPS6KL10.75575216
73RPS6KC10.75575216
74PDPK10.75451481
75LYN0.74310136
76CDK190.73168921
77TTN0.72864951
78MAPK120.72719703
79PNCK0.72620887
80CDC42BPA0.72360469
81MAP3K80.72325835
82MAP3K20.71218145
83LATS10.70915477
84YES10.70426119
85TBK10.68796222
86TESK20.68222927
87STK110.68109714
88TGFBR10.67043044
89JAK10.64949604
90RPS6KA10.64259520
91PDGFRB0.62865520
92CHEK10.62864938
93MARK30.61699971
94TGFBR20.60712350
95NTRK20.60360868
96FGFR20.60229907
97CDK90.60226694
98DAPK20.60125508
99NEK10.59875284
100MAPK70.59676367
101DYRK1B0.58249394
102RPS6KA60.57794298
103SGK30.57417422
104IRAK20.56985363
105CDK20.56844671
106PRKD20.56806142
107PAK20.56415376
108FGFR30.56382565
109NLK0.55771541
110MAPKAPK30.55208149
111CAMK40.55122513
112TSSK60.52940472
113AKT20.51693757
114STK380.51593452
115ERBB20.50970624
116MELK0.49283915
117CAMKK10.49212223
118FYN0.47850224
119DAPK10.47221128
120MATK0.46161158
121MAP3K110.46019472
122HCK0.45934721
123ZAP700.45359090
124CSNK1E0.45138705
125CSK0.44199743
126TAOK20.41429322
127MAPK110.40339029
128RPS6KA20.40226192
129MAP3K60.39352961
130DYRK30.39143599
131HIPK20.38968313
132PRKCH0.38854837
133SCYL20.38585646
134ITK0.37503662
135PASK0.37450845
136MAP2K20.37215246
137PIM10.37214547
138MAPK10.37111393
139CSNK1D0.36668681
140NTRK10.35992861
141CSF1R0.35447190

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043302.38458820
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09801337
3mTOR signaling pathway_Homo sapiens_hsa041501.99162308
4Leishmaniasis_Homo sapiens_hsa051401.89936987
5Chronic myeloid leukemia_Homo sapiens_hsa052201.73247543
6Lysine degradation_Homo sapiens_hsa003101.72666053
7mRNA surveillance pathway_Homo sapiens_hsa030151.66902276
8VEGF signaling pathway_Homo sapiens_hsa043701.66238252
9Dorso-ventral axis formation_Homo sapiens_hsa043201.64957262
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.61725483
11Nitrogen metabolism_Homo sapiens_hsa009101.58803389
12Non-small cell lung cancer_Homo sapiens_hsa052231.55823184
13Basal cell carcinoma_Homo sapiens_hsa052171.55133426
14Hippo signaling pathway_Homo sapiens_hsa043901.53580008
15Graft-versus-host disease_Homo sapiens_hsa053321.52534548
16Adherens junction_Homo sapiens_hsa045201.52443150
17Thyroid hormone signaling pathway_Homo sapiens_hsa049191.50775573
18Neurotrophin signaling pathway_Homo sapiens_hsa047221.47344482
19Allograft rejection_Homo sapiens_hsa053301.44723226
20Measles_Homo sapiens_hsa051621.42432197
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39684518
22Autoimmune thyroid disease_Homo sapiens_hsa053201.39339376
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.38586907
24Acute myeloid leukemia_Homo sapiens_hsa052211.37852515
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37583662
26B cell receptor signaling pathway_Homo sapiens_hsa046621.34284354
27Colorectal cancer_Homo sapiens_hsa052101.33329114
28Glioma_Homo sapiens_hsa052141.32130192
29Endometrial cancer_Homo sapiens_hsa052131.31283394
30Proteoglycans in cancer_Homo sapiens_hsa052051.29872182
31MicroRNAs in cancer_Homo sapiens_hsa052061.29743304
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29223349
33Renal cell carcinoma_Homo sapiens_hsa052111.28874603
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27222098
35Spliceosome_Homo sapiens_hsa030401.26585819
36Influenza A_Homo sapiens_hsa051641.25193619
37Staphylococcus aureus infection_Homo sapiens_hsa051501.24369734
38Tuberculosis_Homo sapiens_hsa051521.23596324
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.22959079
40Other glycan degradation_Homo sapiens_hsa005111.21910642
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.20525353
42Hedgehog signaling pathway_Homo sapiens_hsa043401.17813938
43Thyroid cancer_Homo sapiens_hsa052161.17759628
44Antigen processing and presentation_Homo sapiens_hsa046121.15740594
45T cell receptor signaling pathway_Homo sapiens_hsa046601.14460261
46RNA transport_Homo sapiens_hsa030131.14459432
47Estrogen signaling pathway_Homo sapiens_hsa049151.11843509
48ErbB signaling pathway_Homo sapiens_hsa040121.10488310
49Bladder cancer_Homo sapiens_hsa052191.10480608
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06228606
51Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05983541
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.03141456
53Pancreatic cancer_Homo sapiens_hsa052121.01740000
54Long-term potentiation_Homo sapiens_hsa047201.01544089
55NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01206368
56Viral myocarditis_Homo sapiens_hsa054161.01109803
57Hepatitis C_Homo sapiens_hsa051601.00101952
58Hematopoietic cell lineage_Homo sapiens_hsa046400.98818487
59HTLV-I infection_Homo sapiens_hsa051660.98097445
60Rap1 signaling pathway_Homo sapiens_hsa040150.97882720
61Wnt signaling pathway_Homo sapiens_hsa043100.96907229
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.95730627
63Tight junction_Homo sapiens_hsa045300.94380436
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.93772671
65Oocyte meiosis_Homo sapiens_hsa041140.93444589
66Small cell lung cancer_Homo sapiens_hsa052220.93219939
67Type I diabetes mellitus_Homo sapiens_hsa049400.92953498
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92871109
69Insulin resistance_Homo sapiens_hsa049310.91233050
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91015205
71Choline metabolism in cancer_Homo sapiens_hsa052310.90412990
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90216502
73Shigellosis_Homo sapiens_hsa051310.89267207
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89069231
75TNF signaling pathway_Homo sapiens_hsa046680.88842651
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88122326
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88122016
78Type II diabetes mellitus_Homo sapiens_hsa049300.87702356
79GnRH signaling pathway_Homo sapiens_hsa049120.86491279
80Apoptosis_Homo sapiens_hsa042100.85876403
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85580176
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85406334
83Epstein-Barr virus infection_Homo sapiens_hsa051690.85180410
84Melanogenesis_Homo sapiens_hsa049160.85136296
85Gap junction_Homo sapiens_hsa045400.84958743
86AMPK signaling pathway_Homo sapiens_hsa041520.84339824
87Pathways in cancer_Homo sapiens_hsa052000.84247028
88Endocytosis_Homo sapiens_hsa041440.82358254
89Insulin signaling pathway_Homo sapiens_hsa049100.81118946
90Focal adhesion_Homo sapiens_hsa045100.80410116
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80384872
92MAPK signaling pathway_Homo sapiens_hsa040100.80328891
93Axon guidance_Homo sapiens_hsa043600.80186101
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79734052
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78337407
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77198375
97Malaria_Homo sapiens_hsa051440.76403365
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.75952216
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74834767
100Platelet activation_Homo sapiens_hsa046110.72768579
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72534592
102Osteoclast differentiation_Homo sapiens_hsa043800.72286437
103HIF-1 signaling pathway_Homo sapiens_hsa040660.72173698
104Prolactin signaling pathway_Homo sapiens_hsa049170.71986156
105TGF-beta signaling pathway_Homo sapiens_hsa043500.71661852
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71513946
107Hepatitis B_Homo sapiens_hsa051610.70230039
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.70057870
109Cell cycle_Homo sapiens_hsa041100.67765430
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66842588
111Oxytocin signaling pathway_Homo sapiens_hsa049210.66045418
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65529789
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65040950
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63462530
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.60396899
116Toxoplasmosis_Homo sapiens_hsa051450.59968368
117Gastric acid secretion_Homo sapiens_hsa049710.59764325
118Glucagon signaling pathway_Homo sapiens_hsa049220.59502169
119FoxO signaling pathway_Homo sapiens_hsa040680.59161538
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58847989
121Primary immunodeficiency_Homo sapiens_hsa053400.58588132
122Herpes simplex infection_Homo sapiens_hsa051680.58140598
123Chemokine signaling pathway_Homo sapiens_hsa040620.57866696
124Amoebiasis_Homo sapiens_hsa051460.57607322
125Viral carcinogenesis_Homo sapiens_hsa052030.57232763
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56472832
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.56276128
128Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55120844
129Inositol phosphate metabolism_Homo sapiens_hsa005620.54628239
130Prostate cancer_Homo sapiens_hsa052150.53870809
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53213795
132Legionellosis_Homo sapiens_hsa051340.50859110
133Ras signaling pathway_Homo sapiens_hsa040140.50780731
134Cholinergic synapse_Homo sapiens_hsa047250.49971105
135African trypanosomiasis_Homo sapiens_hsa051430.49153482

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