RNF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.83465328
2L-phenylalanine catabolic process (GO:0006559)5.83465328
3L-phenylalanine metabolic process (GO:0006558)5.56165407
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.56165407
5fatty acid elongation (GO:0030497)4.76906595
6aromatic amino acid family catabolic process (GO:0009074)4.62462844
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.61616891
8axon ensheathment in central nervous system (GO:0032291)4.60550258
9central nervous system myelination (GO:0022010)4.60550258
10ATP synthesis coupled proton transport (GO:0015986)4.54907979
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.54907979
12deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.34012212
13glyoxylate metabolic process (GO:0046487)4.27981153
14establishment of integrated proviral latency (GO:0075713)4.23856772
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.22798585
16cellular ketone body metabolic process (GO:0046950)4.18097653
17pyrimidine nucleobase catabolic process (GO:0006208)4.13051625
18chaperone-mediated protein transport (GO:0072321)4.01557363
19respiratory electron transport chain (GO:0022904)4.00966853
20establishment of viral latency (GO:0019043)3.93150408
21electron transport chain (GO:0022900)3.89505347
22sequestering of actin monomers (GO:0042989)3.89063178
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.88464648
24cholesterol biosynthetic process (GO:0006695)3.86528236
25pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.78546337
26coenzyme catabolic process (GO:0009109)3.73390248
27cysteine metabolic process (GO:0006534)3.65676060
28iron-sulfur cluster assembly (GO:0016226)3.63796115
29metallo-sulfur cluster assembly (GO:0031163)3.63796115
30tryptophan catabolic process (GO:0006569)3.60623322
31indole-containing compound catabolic process (GO:0042436)3.60623322
32indolalkylamine catabolic process (GO:0046218)3.60623322
33alpha-linolenic acid metabolic process (GO:0036109)3.59384646
34aldehyde catabolic process (GO:0046185)3.57769285
35ketone body metabolic process (GO:1902224)3.56572890
36sulfur amino acid catabolic process (GO:0000098)3.51541761
37protein targeting to mitochondrion (GO:0006626)3.48741993
38protein neddylation (GO:0045116)3.44056521
39establishment of mitochondrion localization (GO:0051654)3.41991178
40bile acid biosynthetic process (GO:0006699)3.39976047
41very long-chain fatty acid metabolic process (GO:0000038)3.39728396
42glutathione biosynthetic process (GO:0006750)3.39335269
43sterol biosynthetic process (GO:0016126)3.37250507
44kynurenine metabolic process (GO:0070189)3.36138209
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.34313499
46NADH dehydrogenase complex assembly (GO:0010257)3.34313499
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34313499
48aromatic amino acid family metabolic process (GO:0009072)3.34177027
49establishment of protein localization to mitochondrion (GO:0072655)3.34045950
50aspartate family amino acid catabolic process (GO:0009068)3.33966067
51ribosomal small subunit assembly (GO:0000028)3.26064539
52tryptophan metabolic process (GO:0006568)3.25808448
53positive regulation of mitochondrial fission (GO:0090141)3.25635273
54regulation of mitochondrial translation (GO:0070129)3.25217393
55nonribosomal peptide biosynthetic process (GO:0019184)3.24250651
56short-chain fatty acid metabolic process (GO:0046459)3.23026433
57nucleobase catabolic process (GO:0046113)3.22917365
58protein localization to mitochondrion (GO:0070585)3.20190872
59serine family amino acid biosynthetic process (GO:0009070)3.19227752
60acetyl-CoA metabolic process (GO:0006084)3.18845469
61cofactor catabolic process (GO:0051187)3.15540817
62L-serine metabolic process (GO:0006563)3.14371764
63lysine catabolic process (GO:0006554)3.14129030
64lysine metabolic process (GO:0006553)3.14129030
65protein maturation by protein folding (GO:0022417)3.13210452
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12823467
67peroxisome fission (GO:0016559)3.12520177
68pyrimidine nucleotide catabolic process (GO:0006244)3.11750139
69purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.10050308
70pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.08035005
71branched-chain amino acid catabolic process (GO:0009083)3.06143491
72purine nucleoside triphosphate biosynthetic process (GO:0009145)3.05435287
73protein complex biogenesis (GO:0070271)3.04868960
74glutathione metabolic process (GO:0006749)3.02000648
75alpha-amino acid catabolic process (GO:1901606)3.00577417
76long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.00252052
77acyl-CoA metabolic process (GO:0006637)2.99671916
78thioester metabolic process (GO:0035383)2.99671916
79oxidative phosphorylation (GO:0006119)2.99074583
80cellular amino acid catabolic process (GO:0009063)2.98886327
81thioester biosynthetic process (GO:0035384)2.96932705
82acyl-CoA biosynthetic process (GO:0071616)2.96932705
83fatty-acyl-CoA biosynthetic process (GO:0046949)2.96356660
84cellular biogenic amine catabolic process (GO:0042402)2.95997046
85amine catabolic process (GO:0009310)2.95997046
86bile acid metabolic process (GO:0008206)2.95277161
87glutathione derivative metabolic process (GO:1901685)2.95254448
88glutathione derivative biosynthetic process (GO:1901687)2.95254448
89cullin deneddylation (GO:0010388)2.93711389
90protein deneddylation (GO:0000338)2.92990578
91ribonucleoside triphosphate biosynthetic process (GO:0009201)2.91834475
92mitochondrion transport along microtubule (GO:0047497)2.91374585
93establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.91374585
94negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.91305757
95proteasome assembly (GO:0043248)2.91021711
96amino acid salvage (GO:0043102)2.89289393
97L-methionine salvage (GO:0071267)2.89289393
98L-methionine biosynthetic process (GO:0071265)2.89289393
99positive regulation of cellular amine metabolic process (GO:0033240)2.88972473
100nucleotide transmembrane transport (GO:1901679)2.88813262
101fatty-acyl-CoA metabolic process (GO:0035337)2.88778445
102protein-cofactor linkage (GO:0018065)2.88297018
103ethanol oxidation (GO:0006069)2.87633785
104heme biosynthetic process (GO:0006783)2.86923240
105NADH metabolic process (GO:0006734)2.86117729
106L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85943182
107regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85270793
108aerobic respiration (GO:0009060)2.83963243
109ubiquinone biosynthetic process (GO:0006744)2.83861265
110heme transport (GO:0015886)2.83542773
111base-excision repair, AP site formation (GO:0006285)2.83316061
112protein insertion into membrane (GO:0051205)2.83121409
113regulation of cellular amino acid metabolic process (GO:0006521)2.82651418
114drug catabolic process (GO:0042737)2.82640723
115positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82202932
116cellular modified amino acid catabolic process (GO:0042219)2.81732586
117ubiquinone metabolic process (GO:0006743)2.81179162
118peptidyl-arginine omega-N-methylation (GO:0035247)2.80754839
119mitochondrial transport (GO:0006839)2.80633080
120isoprenoid biosynthetic process (GO:0008299)2.80497518
121negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.80105249
122negative regulation of ligase activity (GO:0051352)2.80105249
123substantia nigra development (GO:0021762)2.80014919
124respiratory chain complex IV assembly (GO:0008535)2.79881012
125triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.78934246
126viral transcription (GO:0019083)2.78197229
127fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.77726179
128GTP biosynthetic process (GO:0006183)2.77078318
129mitochondrial respiratory chain complex assembly (GO:0033108)2.75831648
130drug transmembrane transport (GO:0006855)2.75766522
131anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.75632167
132protoporphyrinogen IX biosynthetic process (GO:0006782)2.74979958
133dicarboxylic acid catabolic process (GO:0043649)2.73047727
134organic acid catabolic process (GO:0016054)2.72977005
135carboxylic acid catabolic process (GO:0046395)2.72977005
136translational termination (GO:0006415)2.71679491
137pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.71679428
138intestinal cholesterol absorption (GO:0030299)2.71031977
139ATP biosynthetic process (GO:0006754)2.70528796
140coenzyme A metabolic process (GO:0015936)2.70431064
141serine family amino acid metabolic process (GO:0009069)2.70236078
142quinone biosynthetic process (GO:1901663)2.70099938
143de novo posttranslational protein folding (GO:0051084)2.69720797
144protoporphyrinogen IX metabolic process (GO:0046501)2.69606420
145negative regulation of telomere maintenance (GO:0032205)2.69379566
146glutamate metabolic process (GO:0006536)2.69167661
147heme metabolic process (GO:0042168)2.68293521
148DNA damage response, detection of DNA damage (GO:0042769)2.68267599
149indolalkylamine metabolic process (GO:0006586)2.67622037
150positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.67350289
151histone arginine methylation (GO:0034969)2.66962487
152response to mercury ion (GO:0046689)2.66522551
153de novo protein folding (GO:0006458)2.66148247
154ribonucleoprotein complex disassembly (GO:0032988)2.65378943
155cytochrome complex assembly (GO:0017004)2.65215525
156negative regulation of DNA-templated transcription, elongation (GO:0032785)2.64851229
157fatty acid catabolic process (GO:0009062)2.63639252
158branched-chain amino acid metabolic process (GO:0009081)2.63481669
159nuclear envelope reassembly (GO:0031468)2.61952144
160mitotic nuclear envelope reassembly (GO:0007084)2.61952144
161peptide biosynthetic process (GO:0043043)2.60825203
162nucleoside triphosphate biosynthetic process (GO:0009142)2.60606984
163DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.60116977
164long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.60043687
165hydrogen ion transmembrane transport (GO:1902600)2.60037325
166monocarboxylic acid catabolic process (GO:0072329)2.59836387
167transcription elongation from RNA polymerase III promoter (GO:0006385)2.59083763
168termination of RNA polymerase III transcription (GO:0006386)2.59083763
169benzene-containing compound metabolic process (GO:0042537)2.59066341
170positive regulation of ligase activity (GO:0051351)2.57497682
171tricarboxylic acid cycle (GO:0006099)2.57286663
172deoxyribonucleotide catabolic process (GO:0009264)2.56079436
173UTP metabolic process (GO:0046051)2.55885010
174kinetochore assembly (GO:0051382)2.55653975
175porphyrin-containing compound biosynthetic process (GO:0006779)2.55576862
176pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.54643400
177proline biosynthetic process (GO:0006561)2.51535589
178SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.51526785
179mitochondrial calcium ion transport (GO:0006851)2.51409360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.44906463
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.85481236
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.58254224
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.07844439
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.00373461
6* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.99002740
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95491739
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.95484596
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.94173739
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.92808814
11E2F7_22180533_ChIP-Seq_HELA_Human2.89347090
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.74642014
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.72277941
14* XRN2_22483619_ChIP-Seq_HELA_Human2.53214408
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45877324
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.42859286
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27088899
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.21673373
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.19351315
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19133915
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18470925
22ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.12259154
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04463252
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95167336
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93613592
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89112086
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83706287
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.80972470
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80145169
30DCP1A_22483619_ChIP-Seq_HELA_Human1.74849104
31FOXP3_21729870_ChIP-Seq_TREG_Human1.74759703
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.74656824
33TTF2_22483619_ChIP-Seq_HELA_Human1.73690529
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70288685
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69059018
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67310664
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.67200298
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.66446719
39* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60958375
40VDR_23849224_ChIP-Seq_CD4+_Human1.60251896
41EZH2_22144423_ChIP-Seq_EOC_Human1.58608294
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.55075891
43VDR_22108803_ChIP-Seq_LS180_Human1.54989931
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.54429297
45ZNF263_19887448_ChIP-Seq_K562_Human1.50481095
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45142750
47CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.42380290
48* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41829838
49HTT_18923047_ChIP-ChIP_STHdh_Human1.39874421
50* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39382180
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39139804
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38163242
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36656211
54IRF1_19129219_ChIP-ChIP_H3396_Human1.33576836
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32681756
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32467778
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31380614
58YY1_22570637_ChIP-Seq_MALME-3M_Human1.30559446
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.30215660
60* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29902713
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29628327
62KDM5A_27292631_Chip-Seq_BREAST_Human1.29276940
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29244681
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28876631
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28841411
66REST_21632747_ChIP-Seq_MESCs_Mouse1.28654823
67CTCF_18555785_ChIP-Seq_MESCs_Mouse1.27149148
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26766636
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26536591
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.26422353
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26089893
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24901640
73* FOXP1_21924763_ChIP-Seq_HESCs_Human1.23081022
74ELK1_19687146_ChIP-ChIP_HELA_Human1.22443774
75CIITA_25753668_ChIP-Seq_RAJI_Human1.21917233
76* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21840148
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21661810
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.21360648
79* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19679135
80* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19657964
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19184776
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18448131
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17698415
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17430715
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17384818
86E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16919362
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16061782
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14014515
89TAF15_26573619_Chip-Seq_HEK293_Human1.13104170
90CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12752700
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11189282
92OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10678350
93CTCF_20526341_ChIP-Seq_ESCs_Human1.10304280
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10090579
95* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09540724
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08869765
97GBX2_23144817_ChIP-Seq_PC3_Human1.07351236
98* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07028893
99JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06657110
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05295300
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04001833
102SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03429300
103* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03426441
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02991612
105SOX2_16153702_ChIP-ChIP_HESCs_Human1.02000245
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99479877
107CTCF_27219007_Chip-Seq_Bcells_Human0.99370989
108ELF1_20517297_ChIP-Seq_JURKAT_Human0.99287351
109EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99269061
110* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98584581
111ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98561397
112BCL6_27268052_Chip-Seq_Bcells_Human0.96621508
113MYC_18940864_ChIP-ChIP_HL60_Human0.95955622
114RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95877074
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95504772
116PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95212129
117MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95123136
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94250043
119P68_20966046_ChIP-Seq_HELA_Human0.93790711
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92818257
121BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92551015
122* DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92064858
123* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91849178
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91561051
125SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.91436804
126EZH2_27304074_Chip-Seq_ESCs_Mouse0.90918482
127NCOR_22424771_ChIP-Seq_293T_Human0.90492812
128SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90272478
129OCT4_20526341_ChIP-Seq_ESCs_Human0.89764024
130* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89187267
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88665170
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87911888
133* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87591675
134TET1_21451524_ChIP-Seq_MESCs_Mouse0.86710670
135* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86415751
136EOMES_21245162_ChIP-Seq_HESCs_Human0.85713291
137JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85414290
138SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.84653591
139ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84571318
140TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84470478
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83751201
142E2F1_21310950_ChIP-Seq_MCF-7_Human0.83661488
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82912062
144* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82457359
145GABP_19822575_ChIP-Seq_HepG2_Human0.82389908
146SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81993502
147NANOG_20526341_ChIP-Seq_ESCs_Human0.80953176
148LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79077770
149PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78973521
150* SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77792878
151SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77535972
152* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77020669
153SOX2_22085726_ChIP-Seq_NPCs_Mouse0.76615507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.00323833
2MP0005360_urolithiasis4.52893533
3MP0005365_abnormal_bile_salt3.73958124
4MP0003806_abnormal_nucleotide_metabolis3.61902619
5MP0005085_abnormal_gallbladder_physiolo3.41430051
6MP0008875_abnormal_xenobiotic_pharmacok3.40735612
7MP0001529_abnormal_vocalization2.87708360
8MP0003122_maternal_imprinting2.82511546
9MP0003693_abnormal_embryo_hatching2.46862306
10MP0005499_abnormal_olfactory_system2.43210537
11MP0005394_taste/olfaction_phenotype2.43210537
12MP0003195_calcinosis2.36980888
13MP0005332_abnormal_amino_acid2.36854414
14MP0006292_abnormal_olfactory_placode2.36234419
15MP0001666_abnormal_nutrient_absorption2.30072049
16MP0005083_abnormal_biliary_tract2.25136950
17MP0003880_abnormal_central_pattern2.14068798
18MP0004043_abnormal_pH_regulation2.14050381
19MP0008058_abnormal_DNA_repair2.06703663
20MP0001188_hyperpigmentation2.04179680
21MP0008932_abnormal_embryonic_tissue2.03324113
22MP0003011_delayed_dark_adaptation2.03315629
23MP0003123_paternal_imprinting2.02075808
24MP0001905_abnormal_dopamine_level1.97972096
25MP0003121_genomic_imprinting1.97673565
26MP0000920_abnormal_myelination1.93563934
27MP0006276_abnormal_autonomic_nervous1.89478818
28MP0008995_early_reproductive_senescence1.88545494
29MP0004957_abnormal_blastocyst_morpholog1.84970715
30MP0003329_amyloid_beta_deposits1.80688906
31MP0003315_abnormal_perineum_morphology1.80558873
32MP0004142_abnormal_muscle_tone1.77109088
33MP0009840_abnormal_foam_cell1.75118592
34MP0006036_abnormal_mitochondrial_physio1.74045770
35MP0003111_abnormal_nucleus_morphology1.73289610
36MP0004270_analgesia1.72032683
37MP0005451_abnormal_body_composition1.70676581
38MP0004019_abnormal_vitamin_homeostasis1.68143940
39MP0003186_abnormal_redox_activity1.64814880
40MP0010329_abnormal_lipoprotein_level1.61936325
41MP0005551_abnormal_eye_electrophysiolog1.58250738
42MP0002638_abnormal_pupillary_reflex1.53972978
43MP0002272_abnormal_nervous_system1.49626005
44MP0005584_abnormal_enzyme/coenzyme_acti1.48768104
45MP0001764_abnormal_homeostasis1.48164265
46MP0001727_abnormal_embryo_implantation1.46405237
47MP0003656_abnormal_erythrocyte_physiolo1.46130937
48MP0001293_anophthalmia1.44924443
49MP0005636_abnormal_mineral_homeostasis1.42948690
50MP0002064_seizures1.42690925
51MP0002118_abnormal_lipid_homeostasis1.42216291
52MP0009643_abnormal_urine_homeostasis1.33507888
53MP0003786_premature_aging1.32594622
54MP0003252_abnormal_bile_duct1.28773190
55MP0002229_neurodegeneration1.26688400
56MP0010030_abnormal_orbit_morphology1.26668638
57MP0002734_abnormal_mechanical_nocicepti1.25769116
58MP0004885_abnormal_endolymph1.24529721
59MP0006035_abnormal_mitochondrial_morpho1.24229841
60MP0003868_abnormal_feces_composition1.24227897
61MP0002735_abnormal_chemical_nociception1.22085927
62MP0005084_abnormal_gallbladder_morpholo1.21051097
63MP0000778_abnormal_nervous_system1.19899026
64MP0002653_abnormal_ependyma_morphology1.19287887
65MP0005423_abnormal_somatic_nervous1.18967934
66MP0005646_abnormal_pituitary_gland1.18831529
67MP0000566_synostosis1.18284657
68MP0002736_abnormal_nociception_after1.17395630
69MP0002876_abnormal_thyroid_physiology1.15872049
70MP0003635_abnormal_synaptic_transmissio1.15704238
71MP0004859_abnormal_synaptic_plasticity1.15633304
72MP0001968_abnormal_touch/_nociception1.15489616
73MP0002733_abnormal_thermal_nociception1.13914994
74MP0002572_abnormal_emotion/affect_behav1.12481730
75MP0009745_abnormal_behavioral_response1.12458414
76MP0003567_abnormal_fetal_cardiomyocyte1.12070484
77MP0002102_abnormal_ear_morphology1.11523447
78MP0010094_abnormal_chromosome_stability1.10971455
79MP0006072_abnormal_retinal_apoptosis1.10668970
80MP0000462_abnormal_digestive_system1.10504481
81MP0001440_abnormal_grooming_behavior1.09433564
82MP0001664_abnormal_digestion1.08669026
83MP0004145_abnormal_muscle_electrophysio1.08513377
84MP0005220_abnormal_exocrine_pancreas1.08457313
85MP0001486_abnormal_startle_reflex1.08380141
86MP0001970_abnormal_pain_threshold1.06568418
87MP0001984_abnormal_olfaction1.05708209
88MP0005645_abnormal_hypothalamus_physiol1.04812036
89MP0004811_abnormal_neuron_physiology1.04747160
90MP0002063_abnormal_learning/memory/cond1.04098978
91MP0003077_abnormal_cell_cycle1.03364939
92MP0002938_white_spotting1.01877735
93MP0003634_abnormal_glial_cell1.01356619
94MP0002751_abnormal_autonomic_nervous1.01284490
95MP0001485_abnormal_pinna_reflex1.01088990
96MP0005319_abnormal_enzyme/_coenzyme0.99370384
97MP0005535_abnormal_body_temperature0.98241027
98MP0005386_behavior/neurological_phenoty0.97232070
99MP0004924_abnormal_behavior0.97232070
100MP0008007_abnormal_cellular_replicative0.96735050
101MP0000049_abnormal_middle_ear0.95301172
102MP0004133_heterotaxia0.94377559
103MP0004147_increased_porphyrin_level0.93320335
104MP0000604_amyloidosis0.91506166
105MP0005253_abnormal_eye_physiology0.91399768
106MP0002132_abnormal_respiratory_system0.89657783
107MP0002557_abnormal_social/conspecific_i0.88630727
108MP0005408_hypopigmentation0.88517182
109MP0000955_abnormal_spinal_cord0.87916124
110MP0001756_abnormal_urination0.86937817
111MP0003183_abnormal_peptide_metabolism0.86785332
112MP0005379_endocrine/exocrine_gland_phen0.86762005
113MP0008872_abnormal_physiological_respon0.86088463
114MP0003690_abnormal_glial_cell0.85945562
115MP0002882_abnormal_neuron_morphology0.85238392
116MP0002067_abnormal_sensory_capabilities0.85193926
117MP0002066_abnormal_motor_capabilities/c0.84791208
118MP0000639_abnormal_adrenal_gland0.84248139
119MP0002822_catalepsy0.82894411
120MP0002752_abnormal_somatic_nervous0.82432361
121MP0003787_abnormal_imprinting0.81264772
122MP0004742_abnormal_vestibular_system0.80223254
123MP0001986_abnormal_taste_sensitivity0.80153860
124MP0002078_abnormal_glucose_homeostasis0.80079331
125MP0008260_abnormal_autophagy0.79954568
126MP0002090_abnormal_vision0.79650027
127MP0001502_abnormal_circadian_rhythm0.78559812
128MP0000372_irregular_coat_pigmentation0.78542849
129MP0001963_abnormal_hearing_physiology0.77854037
130MP0009379_abnormal_foot_pigmentation0.77853508
131MP0002069_abnormal_eating/drinking_beha0.77833855
132MP0001765_abnormal_ion_homeostasis0.77770838
133MP0000609_abnormal_liver_physiology0.77622989
134MP0000631_abnormal_neuroendocrine_gland0.77573200
135MP0003938_abnormal_ear_development0.77201024
136MP0009697_abnormal_copulation0.76316764
137MP0008789_abnormal_olfactory_epithelium0.75459760
138MP0009046_muscle_twitch0.75446980
139MP0003718_maternal_effect0.75021446
140MP0002233_abnormal_nose_morphology0.73209672
141MP0003861_abnormal_nervous_system0.72408459
142MP0002210_abnormal_sex_determination0.69879632
143MP0002152_abnormal_brain_morphology0.69772234
144MP0002184_abnormal_innervation0.68234937
145MP0000358_abnormal_cell_content/0.67495628
146MP0001346_abnormal_lacrimal_gland0.65941080
147MP0000313_abnormal_cell_death0.65833348
148MP0003221_abnormal_cardiomyocyte_apopto0.65629695
149MP0009672_abnormal_birth_weight0.65176039

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.13511185
2Abnormality of glycolysis (HP:0004366)4.55465915
3Increased serum pyruvate (HP:0003542)4.55465915
4Acute necrotizing encephalopathy (HP:0006965)4.28366179
5Acute encephalopathy (HP:0006846)4.27719127
6Abnormal mitochondria in muscle tissue (HP:0008316)4.08640840
7Mitochondrial inheritance (HP:0001427)3.83884248
8Hepatocellular necrosis (HP:0001404)3.83532634
9Hepatic necrosis (HP:0002605)3.76938146
10Cerebral edema (HP:0002181)3.45274204
11Intrahepatic cholestasis (HP:0001406)3.38662407
12Progressive macrocephaly (HP:0004481)3.38117155
13Increased CSF lactate (HP:0002490)3.35167537
14Renal Fanconi syndrome (HP:0001994)3.25572742
15Pheochromocytoma (HP:0002666)3.16544015
16Cortical dysplasia (HP:0002539)3.10427689
17Ketosis (HP:0001946)3.04975076
18Neuroendocrine neoplasm (HP:0100634)3.04544924
19Leukodystrophy (HP:0002415)2.99665161
20Abnormality of the heme biosynthetic pathway (HP:0010472)2.95108060
21Lethargy (HP:0001254)2.84550225
22Ketoacidosis (HP:0001993)2.83823750
23Lactic acidosis (HP:0003128)2.78940461
24Reticulocytopenia (HP:0001896)2.76700691
25Ragged-red muscle fibers (HP:0003200)2.74963800
26Hyperammonemia (HP:0001987)2.74844217
27Hypobetalipoproteinemia (HP:0003563)2.74185303
28Abnormality of monocarboxylic acid metabolism (HP:0010996)2.73285135
29Abnormal number of erythroid precursors (HP:0012131)2.73043415
30Abnormality of cells of the erythroid lineage (HP:0012130)2.70882381
31Lipid accumulation in hepatocytes (HP:0006561)2.68573371
32Increased intramyocellular lipid droplets (HP:0012240)2.67040453
33Cerebral hypomyelination (HP:0006808)2.64882706
34Abnormality of serine family amino acid metabolism (HP:0010894)2.64036180
35Abnormality of glycine metabolism (HP:0010895)2.64036180
36Abnormality of fatty-acid metabolism (HP:0004359)2.63909906
37Abnormality of reticulocytes (HP:0004312)2.62176321
38Dicarboxylic aciduria (HP:0003215)2.62008953
39Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62008953
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.61413549
41Glycosuria (HP:0003076)2.59970461
42Abnormality of urine glucose concentration (HP:0011016)2.59970461
43Increased hepatocellular lipid droplets (HP:0006565)2.59009698
44Cholecystitis (HP:0001082)2.58838887
45Abnormal gallbladder physiology (HP:0012438)2.58838887
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58711014
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58711014
48Myokymia (HP:0002411)2.58458672
49Reticulocytosis (HP:0001923)2.55296357
50Increased muscle lipid content (HP:0009058)2.54341989
51Conjugated hyperbilirubinemia (HP:0002908)2.52372918
52Neurofibrillary tangles (HP:0002185)2.52207669
53Gout (HP:0001997)2.51603973
54Exertional dyspnea (HP:0002875)2.48882434
55Prolonged partial thromboplastin time (HP:0003645)2.48341306
56Hyperlipoproteinemia (HP:0010980)2.48155688
57Hyperglycinuria (HP:0003108)2.48149793
58Increased serum lactate (HP:0002151)2.47310781
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.47126354
60Brushfield spots (HP:0001088)2.46983070
61Generalized aminoaciduria (HP:0002909)2.46545125
62Delayed CNS myelination (HP:0002188)2.46317573
63Respiratory failure (HP:0002878)2.45195892
64Abnormality of renal resorption (HP:0011038)2.42576410
65Cerebral palsy (HP:0100021)2.42037742
66Methylmalonic aciduria (HP:0012120)2.41232405
67Xanthomatosis (HP:0000991)2.40843381
68Abnormality of magnesium homeostasis (HP:0004921)2.39446535
69Deep venous thrombosis (HP:0002625)2.38743163
70Microvesicular hepatic steatosis (HP:0001414)2.38122717
71Hyperglycinemia (HP:0002154)2.37895163
72Abnormality of aspartate family amino acid metabolism (HP:0010899)2.37449144
73Optic disc pallor (HP:0000543)2.36772819
74Hyperphosphaturia (HP:0003109)2.36519281
75Cholelithiasis (HP:0001081)2.36364858
76Hypomagnesemia (HP:0002917)2.35018770
77Vomiting (HP:0002013)2.33010008
78Retinal dysplasia (HP:0007973)2.32027484
793-Methylglutaconic aciduria (HP:0003535)2.31811948
80Respiratory difficulties (HP:0002880)2.30128865
81Hypoglycemic coma (HP:0001325)2.28699108
82Alkalosis (HP:0001948)2.28386355
83Fat malabsorption (HP:0002630)2.27494530
84CNS demyelination (HP:0007305)2.25017782
85Spastic paraparesis (HP:0002313)2.24640102
86Hyperbilirubinemia (HP:0002904)2.22293142
87Metabolic acidosis (HP:0001942)2.21106830
88Polyphagia (HP:0002591)2.20918067
89Methylmalonic acidemia (HP:0002912)2.19395553
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18278518
91Abnormality of methionine metabolism (HP:0010901)2.17223370
92Hyperventilation (HP:0002883)2.13882928
93Amblyopia (HP:0000646)2.13571965
94Increased circulating renin level (HP:0000848)2.10971187
95Opisthotonus (HP:0002179)2.10152665
96Irritability (HP:0000737)2.09772178
97Aplastic anemia (HP:0001915)2.07323268
98Macrocytic anemia (HP:0001972)2.05118004
99Steatorrhea (HP:0002570)2.04660143
100Abnormality of sulfur amino acid metabolism (HP:0004339)2.02312568
101Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02051457
102Abnormal urine phosphate concentration (HP:0012599)2.01710651
103Abnormality of the labia minora (HP:0012880)2.01376034
104Poor suck (HP:0002033)1.97701380
105Abnormality of glutamine family amino acid metabolism (HP:0010902)1.97198805
106Failure to thrive in infancy (HP:0001531)1.95997718
107Gait imbalance (HP:0002141)1.94288624
108Abnormality of the parathyroid morphology (HP:0011766)1.94234798
109Exercise intolerance (HP:0003546)1.94000118
110Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92653831
111Abnormal gallbladder morphology (HP:0012437)1.91895716
112X-linked dominant inheritance (HP:0001423)1.91519667
113Degeneration of anterior horn cells (HP:0002398)1.90767799
114Abnormality of the anterior horn cell (HP:0006802)1.90767799
115Late onset (HP:0003584)1.90481261
116Abnormality of serum amino acid levels (HP:0003112)1.89675902
117Progressive microcephaly (HP:0000253)1.87762797
118Delayed myelination (HP:0012448)1.87107320
119Atrophy/Degeneration involving motor neurons (HP:0007373)1.84456051
120Epiphyseal stippling (HP:0010655)1.83261845
121Metabolic alkalosis (HP:0200114)1.81691639
122Paraparesis (HP:0002385)1.81605883
123Hypokalemic alkalosis (HP:0001949)1.80687752
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80463869
125Proximal tubulopathy (HP:0000114)1.80445384
126Colon cancer (HP:0003003)1.80348073
127Abnormality of vitamin metabolism (HP:0100508)1.80232457
128Emotional lability (HP:0000712)1.80224070
129Hypoplastic pelvis (HP:0008839)1.80078537
130Nephrogenic diabetes insipidus (HP:0009806)1.77731838
131Pallor (HP:0000980)1.76530208
132Abnormality of purine metabolism (HP:0004352)1.75840316
133Multiple enchondromatosis (HP:0005701)1.75437471
134Symptomatic seizures (HP:0011145)1.75348627
135Abnormality of the gallbladder (HP:0005264)1.74934234
136Rhabdomyolysis (HP:0003201)1.72658731
137Upper limb muscle weakness (HP:0003484)1.71969824
138Esotropia (HP:0000565)1.70518885
139Limb dystonia (HP:0002451)1.70269014
140Myopathic facies (HP:0002058)1.67382602
141Congenital primary aphakia (HP:0007707)1.67045266
142Hepatoblastoma (HP:0002884)1.64978878
143Hypoplasia of the brainstem (HP:0002365)1.62393849
144Aplasia/Hypoplasia of the brainstem (HP:0007362)1.62393849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.46550890
2BCKDK3.80443221
3OXSR13.10543691
4TESK23.07897081
5STK392.91778072
6STK162.90471267
7MAP3K122.78964414
8LIMK12.70324400
9BCR2.64316761
10WNK42.56110017
11SRPK12.47341984
12BRSK22.30805291
13WEE12.24325066
14DYRK22.20511505
15MARK12.17510861
16CDK192.16866077
17ARAF2.15307622
18BRSK12.09657833
19NME22.05885426
20SIK31.98426912
21PIM21.85716925
22UHMK11.80722901
23BRAF1.78974242
24DYRK31.72764346
25CSNK1G31.66444537
26TNIK1.56750874
27NME11.53034638
28NEK11.51364419
29WNK31.47060528
30CDC71.46163300
31CASK1.43839428
32CAMK2B1.39566958
33IRAK21.38132983
34MINK11.31374312
35SGK2231.29864047
36SGK4941.29864047
37PBK1.29212181
38ERN11.26984787
39EPHA41.26639976
40MAPK151.24519524
41MAPKAPK51.23833607
42TAOK21.23478760
43EPHB11.19523161
44MYLK1.14906415
45TRIM281.14713258
46MAP4K21.14255299
47KDR1.11401972
48MAPK131.11099658
49CSNK1G21.07780339
50CAMK2G1.07387208
51CDK141.06013229
52MAP2K21.05239398
53CDK181.03131305
54NTRK11.02748971
55CSNK1G11.02141962
56ZAK1.01890658
57EIF2AK11.01635207
58BUB11.01092074
59MAP2K71.00084116
60BMPR1B0.99793989
61CAMK2D0.98810230
62PRPF4B0.97956823
63PLK10.97952897
64PKN10.97794470
65CSNK1A1L0.96242132
66IRAK10.95146621
67CDK150.93830716
68TTK0.92495930
69VRK10.88866649
70PLK40.88374844
71PDK20.88174356
72PLK30.87953839
73MAP2K40.86744231
74CDK11A0.86138386
75MAP3K110.85751819
76INSRR0.84694908
77MAP3K90.80798194
78RPS6KA40.80667321
79NUAK10.80048922
80PAK30.79599567
81NTRK20.78213723
82ERBB40.77877337
83TESK10.77016030
84TAOK30.75873433
85SMG10.75665259
86RPS6KA50.73811916
87ABL20.73790256
88KSR20.72906829
89GRK50.71992288
90TAF10.70860347
91ADRBK20.70020336
92CAMK2A0.69768265
93NEK60.66977132
94CDK50.66444603
95LMTK20.66369567
96ROCK20.64541471
97PRKCZ0.62929563
98CHEK20.62887835
99CSNK2A20.62502625
100DAPK30.61495099
101EPHB20.61391174
102AURKB0.60820902
103EIF2AK30.60430223
104ATR0.58914683
105PRKCG0.58348290
106CSNK2A10.58061024
107PNCK0.55253431
108MUSK0.55148706
109CDK80.53389515
110PAK60.51106677
111GRK70.50272993
112KSR10.49901306
113PRKACA0.49223599
114MAP3K40.48435191
115MAPK40.47905579
116CCNB10.47766426
117MAP2K10.46709331
118DAPK20.46274262
119CDK70.46124404
120NEK20.44999133
121MAP2K60.44240097
122CSNK1E0.42834860
123MAPK120.42667897
124ADRBK10.42609344
125PRKCI0.42310501
126AURKA0.41638841
127PRKCE0.41568826
128DAPK10.41565709
129ERBB20.41421552
130RAF10.40722014
131DYRK1B0.40317251
132ILK0.38992236
133MAP3K50.38336900
134PRKACG0.38270639
135PHKG20.37000998
136PHKG10.37000998
137PAK10.36477126
138PINK10.36018611
139CSNK1A10.35915999
140OBSCN0.35908041
141DYRK1A0.34140095
142AKT20.32008714
143EIF2AK20.30982969
144CDK40.30352134
145ICK0.30050979
146LRRK20.29717602

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.44616200
2Oxidative phosphorylation_Homo sapiens_hsa001903.10081985
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.89363380
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.64774593
5Parkinsons disease_Homo sapiens_hsa050122.58752989
6Fatty acid elongation_Homo sapiens_hsa000622.55436566
7Butanoate metabolism_Homo sapiens_hsa006502.48779625
8Sulfur metabolism_Homo sapiens_hsa009202.45903109
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39483290
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.38001798
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34049358
12DNA replication_Homo sapiens_hsa030302.24605599
13Steroid biosynthesis_Homo sapiens_hsa001002.24347410
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23197250
15Base excision repair_Homo sapiens_hsa034102.20227564
16Propanoate metabolism_Homo sapiens_hsa006402.01177553
17Protein export_Homo sapiens_hsa030601.97522335
18Mismatch repair_Homo sapiens_hsa034301.92222690
19Peroxisome_Homo sapiens_hsa041461.92203828
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.89145765
21Pyruvate metabolism_Homo sapiens_hsa006201.87357101
22Tryptophan metabolism_Homo sapiens_hsa003801.86837292
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.86409760
24Alzheimers disease_Homo sapiens_hsa050101.84343214
25Folate biosynthesis_Homo sapiens_hsa007901.75042130
26Fatty acid degradation_Homo sapiens_hsa000711.72142750
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70593665
28Nitrogen metabolism_Homo sapiens_hsa009101.68035095
29Histidine metabolism_Homo sapiens_hsa003401.66616805
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66417461
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61197166
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58577750
33Spliceosome_Homo sapiens_hsa030401.57812534
34Fatty acid metabolism_Homo sapiens_hsa012121.55727837
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53821877
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51010949
37Huntingtons disease_Homo sapiens_hsa050161.49951314
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47332285
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.42034534
40Arginine biosynthesis_Homo sapiens_hsa002201.41738917
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40228281
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39037798
43Chemical carcinogenesis_Homo sapiens_hsa052041.38904908
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35733370
45Arginine and proline metabolism_Homo sapiens_hsa003301.26084603
46beta-Alanine metabolism_Homo sapiens_hsa004101.25802608
47Carbon metabolism_Homo sapiens_hsa012001.24444803
48Homologous recombination_Homo sapiens_hsa034401.24075466
49Glutathione metabolism_Homo sapiens_hsa004801.23813503
50Sulfur relay system_Homo sapiens_hsa041221.16712764
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.14752321
52Nucleotide excision repair_Homo sapiens_hsa034201.13550148
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.10790322
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08572315
55Fat digestion and absorption_Homo sapiens_hsa049751.08171528
56Biosynthesis of amino acids_Homo sapiens_hsa012301.05487404
57Collecting duct acid secretion_Homo sapiens_hsa049661.02837097
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01144668
59Proteasome_Homo sapiens_hsa030501.00945447
60Cardiac muscle contraction_Homo sapiens_hsa042601.00260014
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97947714
62Vitamin B6 metabolism_Homo sapiens_hsa007500.97543574
63Tyrosine metabolism_Homo sapiens_hsa003500.97331822
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.95876059
65Phenylalanine metabolism_Homo sapiens_hsa003600.95491077
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94521798
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93201726
68Metabolic pathways_Homo sapiens_hsa011000.90416665
69Selenocompound metabolism_Homo sapiens_hsa004500.88754808
70Purine metabolism_Homo sapiens_hsa002300.84969480
71RNA transport_Homo sapiens_hsa030130.83719879
72PPAR signaling pathway_Homo sapiens_hsa033200.83325879
73Retinol metabolism_Homo sapiens_hsa008300.82616450
74Cell cycle_Homo sapiens_hsa041100.81324334
75Fanconi anemia pathway_Homo sapiens_hsa034600.80995420
76Vibrio cholerae infection_Homo sapiens_hsa051100.77042486
77Bile secretion_Homo sapiens_hsa049760.75020535
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74294405
79Ether lipid metabolism_Homo sapiens_hsa005650.73475987
80Phototransduction_Homo sapiens_hsa047440.73447815
81Synaptic vesicle cycle_Homo sapiens_hsa047210.72113997
82Linoleic acid metabolism_Homo sapiens_hsa005910.71651900
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71065739
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64614687
85Pentose phosphate pathway_Homo sapiens_hsa000300.63790418
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62462605
87One carbon pool by folate_Homo sapiens_hsa006700.62280774
88Non-homologous end-joining_Homo sapiens_hsa034500.62127454
89Complement and coagulation cascades_Homo sapiens_hsa046100.60844230
90Basal transcription factors_Homo sapiens_hsa030220.60291347
91Fructose and mannose metabolism_Homo sapiens_hsa000510.60120297
92Caffeine metabolism_Homo sapiens_hsa002320.58570038
93RNA degradation_Homo sapiens_hsa030180.57080518
94Starch and sucrose metabolism_Homo sapiens_hsa005000.53018061
95Vitamin digestion and absorption_Homo sapiens_hsa049770.52338211
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48655321
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47724444
98Glycerolipid metabolism_Homo sapiens_hsa005610.47277741
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45661931
100RNA polymerase_Homo sapiens_hsa030200.43305418
101N-Glycan biosynthesis_Homo sapiens_hsa005100.41258265
102mRNA surveillance pathway_Homo sapiens_hsa030150.40615951
103GABAergic synapse_Homo sapiens_hsa047270.40483990
104Regulation of autophagy_Homo sapiens_hsa041400.39299065
105Arachidonic acid metabolism_Homo sapiens_hsa005900.36729947
106ABC transporters_Homo sapiens_hsa020100.34855433
107Ribosome_Homo sapiens_hsa030100.34554452
108Pancreatic secretion_Homo sapiens_hsa049720.31672639
109Galactose metabolism_Homo sapiens_hsa000520.31270571
110Nicotine addiction_Homo sapiens_hsa050330.30828387
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30761415
112Oocyte meiosis_Homo sapiens_hsa041140.28951819
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27342797
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.23064111
115Cocaine addiction_Homo sapiens_hsa050300.22884205
116Alcoholism_Homo sapiens_hsa050340.22875682
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19728092
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17365486
119Lysosome_Homo sapiens_hsa041420.15865990
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15144139
121Serotonergic synapse_Homo sapiens_hsa047260.13644308
122Sphingolipid metabolism_Homo sapiens_hsa006000.13417450
123Insulin secretion_Homo sapiens_hsa049110.12773584
124Pyrimidine metabolism_Homo sapiens_hsa002400.12746947

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