RNF5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.65654201
2sequestering of actin monomers (GO:0042989)7.52045858
3ATP synthesis coupled proton transport (GO:0015986)6.91491612
4energy coupled proton transport, down electrochemical gradient (GO:0015985)6.91491612
5viral transcription (GO:0019083)5.73470772
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.63569064
7translational termination (GO:0006415)5.56296692
8regulation of glucokinase activity (GO:0033131)5.52042196
9regulation of hexokinase activity (GO:1903299)5.52042196
10respiratory electron transport chain (GO:0022904)5.42306446
11protein neddylation (GO:0045116)5.32093278
12electron transport chain (GO:0022900)5.30413944
13positive regulation of gastrulation (GO:2000543)5.16407711
14cytidine metabolic process (GO:0046087)4.85960992
15cytidine catabolic process (GO:0006216)4.85960992
16cytidine deamination (GO:0009972)4.85960992
17ribosomal small subunit assembly (GO:0000028)4.77053086
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.75378669
19cotranslational protein targeting to membrane (GO:0006613)4.71919268
20translational elongation (GO:0006414)4.71658004
21protein targeting to ER (GO:0045047)4.64268544
22DNA damage response, detection of DNA damage (GO:0042769)4.53203279
23protein localization to endoplasmic reticulum (GO:0070972)4.49659137
24cellular protein complex disassembly (GO:0043624)4.48159937
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.46791581
26primitive streak formation (GO:0090009)4.32624741
27microtubule depolymerization (GO:0007019)4.31528395
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.20033699
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.06688029
30viral life cycle (GO:0019058)4.04218723
31protein complex disassembly (GO:0043241)3.95405010
32pyrimidine ribonucleoside catabolic process (GO:0046133)3.89581673
33dopaminergic neuron differentiation (GO:0071542)3.86680881
34protein complex biogenesis (GO:0070271)3.80296940
35amyloid precursor protein catabolic process (GO:0042987)3.79658325
36ATP biosynthetic process (GO:0006754)3.79288685
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.79246043
38ribosomal small subunit biogenesis (GO:0042274)3.73106741
39macromolecular complex disassembly (GO:0032984)3.72054061
40negative regulation by host of viral transcription (GO:0043922)3.65125516
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.64280315
42NADH dehydrogenase complex assembly (GO:0010257)3.64280315
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.64280315
44somite rostral/caudal axis specification (GO:0032525)3.63140483
45maturation of SSU-rRNA (GO:0030490)3.60714685
46mitochondrial respiratory chain complex assembly (GO:0033108)3.59149461
47protein K6-linked ubiquitination (GO:0085020)3.58915849
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.56102846
49translational initiation (GO:0006413)3.52519127
50regulation of activation of Janus kinase activity (GO:0010533)3.52295885
51chaperone-mediated protein transport (GO:0072321)3.42468995
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.37404551
53purine nucleoside triphosphate biosynthetic process (GO:0009145)3.34495639
54mannosylation (GO:0097502)3.33486700
55dorsal/ventral neural tube patterning (GO:0021904)3.32818583
56hydrogen ion transmembrane transport (GO:1902600)3.31749556
57regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.30787757
58regulation of autophagic vacuole assembly (GO:2000785)3.25718806
59inner mitochondrial membrane organization (GO:0007007)3.25071615
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20221575
61DNA deamination (GO:0045006)3.19261417
62translation (GO:0006412)3.12610221
63nuclear-transcribed mRNA catabolic process (GO:0000956)3.11980383
64proton transport (GO:0015992)3.11209529
65alkaloid metabolic process (GO:0009820)3.08953748
66positive regulation of male gonad development (GO:2000020)3.08051705
67negative T cell selection (GO:0043383)3.06985511
68RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04853352
69tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04853352
70hydrogen transport (GO:0006818)3.01869354
71axonemal dynein complex assembly (GO:0070286)3.01668930
72response to insecticide (GO:0017085)2.98209598
73GPI anchor metabolic process (GO:0006505)2.96580700
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.96082929
75indolalkylamine metabolic process (GO:0006586)2.94278947
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93664416
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92873505
78mRNA catabolic process (GO:0006402)2.91744178
79Arp2/3 complex-mediated actin nucleation (GO:0034314)2.90396304
80ribonucleoside triphosphate biosynthetic process (GO:0009201)2.87544756
81protein targeting to membrane (GO:0006612)2.86334248
82GPI anchor biosynthetic process (GO:0006506)2.85734930
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83397509
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83397509
85neural tube formation (GO:0001841)2.82349358
86negative regulation of B cell apoptotic process (GO:0002903)2.81114556
87midbrain development (GO:0030901)2.81002947
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.79419622
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.79419622
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.79419622
91negative thymic T cell selection (GO:0045060)2.73638710
92epithelial cilium movement (GO:0003351)2.73039892
93pseudouridine synthesis (GO:0001522)2.71724204
94regulation of male gonad development (GO:2000018)2.70543111
95eosinophil chemotaxis (GO:0048245)2.70059095
96ADP metabolic process (GO:0046031)2.69758682
97negative regulation of ligase activity (GO:0051352)2.69516115
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69516115
99signal transduction involved in DNA integrity checkpoint (GO:0072401)2.68536833
100signal transduction involved in DNA damage checkpoint (GO:0072422)2.68536833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.93687085
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.55931937
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.89648867
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.42700802
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.20228063
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.16084888
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.04777633
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.97161376
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.87217766
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85542691
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65602744
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46839155
13VDR_22108803_ChIP-Seq_LS180_Human2.25511197
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.23816510
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19048151
16VDR_23849224_ChIP-Seq_CD4+_Human2.18434549
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15992291
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.12967140
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.08853317
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06781922
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02729018
22ZNF274_21170338_ChIP-Seq_K562_Hela1.94410596
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88247404
24ELK1_19687146_ChIP-ChIP_HELA_Human1.85968338
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81770535
26* XRN2_22483619_ChIP-Seq_HELA_Human1.78045228
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77203287
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.71241224
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67208881
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66570939
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63668447
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.61705511
33CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.60337048
34FOXP3_21729870_ChIP-Seq_TREG_Human1.55932495
35IGF1R_20145208_ChIP-Seq_DFB_Human1.53837549
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53189119
37TTF2_22483619_ChIP-Seq_HELA_Human1.50281951
38SOX2_16153702_ChIP-ChIP_HESCs_Human1.44615739
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.44435753
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.44394603
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39634270
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37399702
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37199805
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35690091
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32315922
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31545031
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29085812
48HTT_18923047_ChIP-ChIP_STHdh_Human1.28494749
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25530506
50* ERG_20517297_ChIP-Seq_VCAP_Human1.25047578
51RNF2_27304074_Chip-Seq_NSC_Mouse1.23513625
52MYC_18940864_ChIP-ChIP_HL60_Human1.20493141
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20232352
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19701974
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15515694
56EZH2_22144423_ChIP-Seq_EOC_Human1.14318383
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14225108
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14169785
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.13618547
60ERA_21632823_ChIP-Seq_H3396_Human1.12934254
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10731204
62IRF1_19129219_ChIP-ChIP_H3396_Human1.10525120
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10205544
64EWS_26573619_Chip-Seq_HEK293_Human1.09486210
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06498104
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04709623
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01796396
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01487743
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99682697
70LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97868970
71CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97402266
72EZH2_27304074_Chip-Seq_ESCs_Mouse0.97252167
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96838323
74YY1_22570637_ChIP-Seq_MALME-3M_Human0.96816414
75CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95023360
76AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93929436
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93384872
78WDR5_24793694_ChIP-Seq_LNCAP_Human0.91783515
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91714518
80MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91447534
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91179624
82EGR1_19032775_ChIP-ChIP_M12_Human0.90491892
83JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90329342
84PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88679911
85TAF2_19829295_ChIP-Seq_ESCs_Human0.88447039
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88178688
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87988408
88SOX2_22085726_ChIP-Seq_NPCs_Mouse0.87096651
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82814446
90TP53_22573176_ChIP-Seq_HFKS_Human0.82510597
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82502964
92NANOG_16153702_ChIP-ChIP_HESCs_Human0.80837435
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80464883
94DCP1A_22483619_ChIP-Seq_HELA_Human0.77925227
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.77264214
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76940856
97SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76899644
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76815189
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76646351
100ERG_21242973_ChIP-ChIP_JURKAT_Human0.75633958

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.43428990
2MP0006292_abnormal_olfactory_placode4.56992459
3MP0002277_abnormal_respiratory_mucosa3.80728658
4MP0003011_delayed_dark_adaptation3.68991469
5MP0000569_abnormal_digit_pigmentation3.18190887
6MP0003136_yellow_coat_color2.83298167
7MP0003890_abnormal_embryonic-extraembry2.80433327
8MP0005084_abnormal_gallbladder_morpholo2.76868539
9MP0002102_abnormal_ear_morphology2.71121937
10MP0003283_abnormal_digestive_organ2.60341696
11MP0001188_hyperpigmentation2.47217071
12MP0004133_heterotaxia2.34517280
13MP0001529_abnormal_vocalization2.26128321
14MP0000372_irregular_coat_pigmentation2.12957034
15MP0003880_abnormal_central_pattern2.03538793
16MP0008961_abnormal_basal_metabolism2.00962003
17MP0002938_white_spotting1.87900959
18MP0008995_early_reproductive_senescence1.87069374
19MP0005671_abnormal_response_to1.83920045
20MP0001905_abnormal_dopamine_level1.83717092
21MP0001348_abnormal_lacrimal_gland1.75084970
22MP0002234_abnormal_pharynx_morphology1.61716172
23MP0002751_abnormal_autonomic_nervous1.61680039
24MP0008789_abnormal_olfactory_epithelium1.60655851
25MP0005253_abnormal_eye_physiology1.57869042
26MP0002736_abnormal_nociception_after1.49076958
27MP0000049_abnormal_middle_ear1.47297005
28MP0002837_dystrophic_cardiac_calcinosis1.47126353
29MP0010030_abnormal_orbit_morphology1.46570576
30MP0000465_gastrointestinal_hemorrhage1.41594400
31MP0001293_anophthalmia1.39342638
32MP0000631_abnormal_neuroendocrine_gland1.35372435
33MP0003119_abnormal_digestive_system1.33503086
34MP0006072_abnormal_retinal_apoptosis1.32319302
35MP0008058_abnormal_DNA_repair1.27209730
36MP0005394_taste/olfaction_phenotype1.25198445
37MP0005499_abnormal_olfactory_system1.25198445
38MP0001485_abnormal_pinna_reflex1.24352761
39MP0004742_abnormal_vestibular_system1.18049685
40MP0009785_altered_susceptibility_to1.15164355
41MP0005379_endocrine/exocrine_gland_phen1.11453085
42MP0003806_abnormal_nucleotide_metabolis1.11290508
43MP0003866_abnormal_defecation1.06342779
44MP0000751_myopathy1.05394817
45MP0001968_abnormal_touch/_nociception1.04416219
46MP0003938_abnormal_ear_development1.04265457
47MP0002095_abnormal_skin_pigmentation1.03825480
48MP0000566_synostosis0.97684986
49MP0001879_abnormal_lymphatic_vessel0.95158808
50MP0002822_catalepsy0.95009725
51MP0002148_abnormal_hypersensitivity_rea0.93914898
52MP0001346_abnormal_lacrimal_gland0.90878246
53MP0002697_abnormal_eye_size0.90811366
54MP0004924_abnormal_behavior0.90177871
55MP0005386_behavior/neurological_phenoty0.90177871
56MP0009333_abnormal_splenocyte_physiolog0.89142028
57MP0006035_abnormal_mitochondrial_morpho0.88392255
58MP0005389_reproductive_system_phenotype0.87953548
59MP0001286_abnormal_eye_development0.86403850
60MP0008872_abnormal_physiological_respon0.85053236
61MP0004883_abnormal_blood_vessel0.84571274
62MP0005551_abnormal_eye_electrophysiolog0.84011771
63MP0001944_abnormal_pancreas_morphology0.83726680
64MP0005391_vision/eye_phenotype0.82303072
65MP0003878_abnormal_ear_physiology0.81615395
66MP0005377_hearing/vestibular/ear_phenot0.81615395
67MP0005000_abnormal_immune_tolerance0.81193438
68MP0002693_abnormal_pancreas_physiology0.79573102
69MP0001919_abnormal_reproductive_system0.79379565
70MP0006036_abnormal_mitochondrial_physio0.78582915
71MP0005423_abnormal_somatic_nervous0.78387709
72MP0002928_abnormal_bile_duct0.77018426
73MP0004142_abnormal_muscle_tone0.76889697
74MP0002282_abnormal_trachea_morphology0.76730741
75MP0005645_abnormal_hypothalamus_physiol0.76723445
76MP0001764_abnormal_homeostasis0.75522009
77MP0004145_abnormal_muscle_electrophysio0.72925744
78MP0003959_abnormal_lean_body0.72733759
79MP0000778_abnormal_nervous_system0.71309335
80MP0000647_abnormal_sebaceous_gland0.70217549
81MP0000026_abnormal_inner_ear0.70181924
82MP0003646_muscle_fatigue0.69610397
83MP0005636_abnormal_mineral_homeostasis0.67991955
84MP0002272_abnormal_nervous_system0.67105458
85MP0002160_abnormal_reproductive_system0.66935517
86MP0009053_abnormal_anal_canal0.66897658
87MP0003786_premature_aging0.66270096
88MP0005167_abnormal_blood-brain_barrier0.65403112
89MP0003186_abnormal_redox_activity0.64626073
90MP0004957_abnormal_blastocyst_morpholog0.62128315
91MP0008873_increased_physiological_sensi0.62117070
92MP0003937_abnormal_limbs/digits/tail_de0.61550455
93MP0001984_abnormal_olfaction0.58983999
94MP0002876_abnormal_thyroid_physiology0.58508906
95MP0003693_abnormal_embryo_hatching0.58120514
96MP0002163_abnormal_gland_morphology0.57984799
97MP0009697_abnormal_copulation0.56961416
98MP0005187_abnormal_penis_morphology0.56164138
99MP0001486_abnormal_startle_reflex0.54818821
100MP0003195_calcinosis0.53632208

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)5.12291812
2Hepatic necrosis (HP:0002605)4.86478236
3Mitochondrial inheritance (HP:0001427)4.71939327
4True hermaphroditism (HP:0010459)4.48153848
5Abnormal mitochondria in muscle tissue (HP:0008316)4.47425158
6Acute necrotizing encephalopathy (HP:0006965)4.46142899
7Abnormal pupillary function (HP:0007686)4.01394512
8Supernumerary spleens (HP:0009799)3.95030664
9Increased CSF lactate (HP:0002490)3.79371918
10Hypothermia (HP:0002045)3.74511413
11Abnormal number of erythroid precursors (HP:0012131)3.72867965
12Abnormal ciliary motility (HP:0012262)3.67019466
13Acute encephalopathy (HP:0006846)3.63774195
14Abnormality of cells of the erythroid lineage (HP:0012130)3.52215016
15Progressive macrocephaly (HP:0004481)3.50771429
16Increased intramyocellular lipid droplets (HP:0012240)3.46395658
17Increased hepatocellular lipid droplets (HP:0006565)3.42318620
18Abnormal respiratory motile cilium physiology (HP:0012261)3.26170230
19Cerebral edema (HP:0002181)3.20109207
20Renal Fanconi syndrome (HP:0001994)3.11832707
21Short tibia (HP:0005736)3.10652911
22Absent septum pellucidum (HP:0001331)2.98158979
23Occipital encephalocele (HP:0002085)2.95669585
24Aplastic anemia (HP:0001915)2.94913977
25Pancreatic fibrosis (HP:0100732)2.89349168
26Lipid accumulation in hepatocytes (HP:0006561)2.86265371
27Septo-optic dysplasia (HP:0100842)2.84287947
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.81000465
29Pancreatic cysts (HP:0001737)2.79772191
30Limb dystonia (HP:0002451)2.79622959
31Chronic sinusitis (HP:0011109)2.75534178
32Aplasia/Hypoplasia of the tibia (HP:0005772)2.75350871
33Increased muscle lipid content (HP:0009058)2.73548232
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.62323060
35Absent/shortened dynein arms (HP:0200106)2.62323060
36Congenital, generalized hypertrichosis (HP:0004540)2.61805017
37Generalized aminoaciduria (HP:0002909)2.59614015
38Bilateral microphthalmos (HP:0007633)2.57339433
39Oral leukoplakia (HP:0002745)2.46861148
40Short middle phalanx of the 5th finger (HP:0004220)2.45690968
41Parakeratosis (HP:0001036)2.43032233
42Myokymia (HP:0002411)2.34091854
43Abnormal lung lobation (HP:0002101)2.32475512
44Molar tooth sign on MRI (HP:0002419)2.32095431
45Abnormality of midbrain morphology (HP:0002418)2.32095431
463-Methylglutaconic aciduria (HP:0003535)2.30752727
47Nephronophthisis (HP:0000090)2.30145756
48Type I transferrin isoform profile (HP:0003642)2.29050982
49Lactic acidosis (HP:0003128)2.28880874
50Abnormality of the septum pellucidum (HP:0007375)2.27468442
51Limb hypertonia (HP:0002509)2.24788878
52Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.23900610
53Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.22550795
54Abnormal respiratory epithelium morphology (HP:0012253)2.22505313
55Abnormal respiratory motile cilium morphology (HP:0005938)2.22505313
56Sclerocornea (HP:0000647)2.19763361
57Anencephaly (HP:0002323)2.19015212
58Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.18667656
59Abnormality of the phalanges of the 5th finger (HP:0004213)2.17884454
60Respiratory failure (HP:0002878)2.16748697
61Male pseudohermaphroditism (HP:0000037)2.16506871
62Optic disc pallor (HP:0000543)2.16369403
63Mesomelia (HP:0003027)2.14875561
64Macrocytic anemia (HP:0001972)2.13811131
65Sex reversal (HP:0012245)2.11115113
66Abnormal sex determination (HP:0012244)2.11115113
67Emotional lability (HP:0000712)2.09622834
68Reticulocytopenia (HP:0001896)2.08296441
69Increased serum lactate (HP:0002151)2.05395142
70Pendular nystagmus (HP:0012043)2.04189331
71Exercise intolerance (HP:0003546)2.03910591
72Pallor (HP:0000980)2.01583252
73Medial flaring of the eyebrow (HP:0010747)2.01179386
74Chronic otitis media (HP:0000389)1.99530139
75Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98695694
76Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98695694
77Median cleft lip (HP:0000161)1.97203557
78Congenital hepatic fibrosis (HP:0002612)1.97164404
79Sparse eyelashes (HP:0000653)1.96060392
80Maternal diabetes (HP:0009800)1.95838887
81Leukodystrophy (HP:0002415)1.94418559
82Exertional dyspnea (HP:0002875)1.91556321
83CNS demyelination (HP:0007305)1.90110687
84Renal cortical cysts (HP:0000803)1.89810799
85Cystic liver disease (HP:0006706)1.88088902
86Glycosuria (HP:0003076)1.85812424
87Abnormality of urine glucose concentration (HP:0011016)1.85812424
88Rhinitis (HP:0012384)1.84534486
89Hemivertebrae (HP:0002937)1.83220953
90Proximal tubulopathy (HP:0000114)1.82579875
91Bile duct proliferation (HP:0001408)1.82571230
92Abnormal biliary tract physiology (HP:0012439)1.82571230
93Abnormality of renal resorption (HP:0011038)1.81492249
94Preaxial hand polydactyly (HP:0001177)1.81440133
95Renal dysplasia (HP:0000110)1.80908285
96Abnormality of the renal medulla (HP:0100957)1.80165739
97Elevated erythrocyte sedimentation rate (HP:0003565)1.78072209
98Down-sloping shoulders (HP:0200021)1.77933832
99Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76845236
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76618240

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.66406230
2VRK13.52977529
3TLK13.24805628
4BUB13.18621090
5KDR3.18065106
6MAPK152.82726084
7CCNB12.65419230
8BRSK22.53292331
9BCKDK2.28066036
10ZAK2.22060225
11NME12.21435416
12ADRBK22.07272430
13PIM22.04866253
14MAPK132.00372790
15WEE11.97311797
16UHMK11.96550979
17TESK21.89457609
18PIK3CG1.51242666
19WNK31.50584905
20DYRK31.47028443
21TXK1.46945412
22PDK21.46205690
23EPHB21.39966706
24NTRK31.37922506
25PIM11.31415459
26NUAK11.29829721
27GRK11.27730874
28RPS6KA51.18475982
29GRK61.18475259
30DYRK21.17959073
31SRPK11.16742477
32PNCK1.14790743
33BRSK11.11922766
34MAP3K101.10691417
35OBSCN1.09751004
36WNK41.09081521
37STK161.07893085
38MARK11.03862086
39NEK10.98745709
40MAP2K70.97772013
41GRK70.96515458
42PASK0.94366916
43TESK10.91074927
44PLK30.83495502
45DYRK1B0.81832353
46CHUK0.80597698
47TRIM280.80383334
48MUSK0.76590098
49DYRK1A0.75140092
50CDK30.74692268
51RPS6KA40.74469739
52PBK0.74199917
53MAPK40.73835665
54PLK10.71566169
55TIE10.70885256
56PIK3CA0.70747238
57INSRR0.70655873
58MAP3K110.69830394
59AURKA0.69830078
60LRRK20.67440127
61PTK2B0.67190311
62PRKCG0.66762346
63PRKCQ0.64903851
64NEK20.64165408
65AURKB0.63505411
66PAK10.61804872
67PRKACA0.59808831
68MAP3K40.58702326
69MAP4K20.57816530
70IKBKE0.57496670
71ARAF0.48582026
72IKBKB0.48466217
73EIF2AK10.47692360
74NEK90.47514874
75BMPR1B0.47452273
76CSNK2A10.46652584
77CSNK2A20.46624263
78CAMK2B0.46558875
79PHKG20.46208874
80PHKG10.46208874
81MKNK10.45171362
82CSNK1G10.43664705
83ITK0.43397213
84DAPK30.41701838
85LIMK10.41495536
86LCK0.40937812
87PRKCB0.40675202
88MAP3K50.39945899
89CSNK1G20.39709851
90BRAF0.38938525
91MAP4K10.38740683
92MAPK70.37865630
93MATK0.37737173
94ABL20.37400060
95ADRBK10.37198832
96TBK10.36395157
97EPHA40.36075069
98TNIK0.35074652
99MST40.33422800
100FES0.32774071

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.32800944
2Ribosome_Homo sapiens_hsa030105.12729687
3Parkinsons disease_Homo sapiens_hsa050124.52672242
4Proteasome_Homo sapiens_hsa030503.72079343
5Huntingtons disease_Homo sapiens_hsa050163.16351397
6Alzheimers disease_Homo sapiens_hsa050103.14494599
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.93987763
8Primary immunodeficiency_Homo sapiens_hsa053402.81261135
9RNA polymerase_Homo sapiens_hsa030202.64086150
10Cardiac muscle contraction_Homo sapiens_hsa042602.35446064
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.28099990
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.09250365
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03049729
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86178461
15Spliceosome_Homo sapiens_hsa030401.80887577
16Phenylalanine metabolism_Homo sapiens_hsa003601.57771695
17Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.55850933
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52154348
19Nucleotide excision repair_Homo sapiens_hsa034201.40084564
20Butanoate metabolism_Homo sapiens_hsa006501.39106280
21Tryptophan metabolism_Homo sapiens_hsa003801.35447213
22Homologous recombination_Homo sapiens_hsa034401.34261247
23Pyruvate metabolism_Homo sapiens_hsa006201.23357616
24RNA degradation_Homo sapiens_hsa030181.16482627
25Propanoate metabolism_Homo sapiens_hsa006401.15612344
26Protein export_Homo sapiens_hsa030601.12077384
27Nitrogen metabolism_Homo sapiens_hsa009101.07110949
28DNA replication_Homo sapiens_hsa030301.06436629
29Antigen processing and presentation_Homo sapiens_hsa046121.05735616
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04659568
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00724030
32Hematopoietic cell lineage_Homo sapiens_hsa046400.99620846
33Tyrosine metabolism_Homo sapiens_hsa003500.99562442
34Peroxisome_Homo sapiens_hsa041460.97588152
35Systemic lupus erythematosus_Homo sapiens_hsa053220.97123527
36Caffeine metabolism_Homo sapiens_hsa002320.96758862
37Mismatch repair_Homo sapiens_hsa034300.95322696
38Fanconi anemia pathway_Homo sapiens_hsa034600.93357891
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91017089
40Graft-versus-host disease_Homo sapiens_hsa053320.83282417
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79480410
42Collecting duct acid secretion_Homo sapiens_hsa049660.79355125
43Steroid biosynthesis_Homo sapiens_hsa001000.77334585
44Rheumatoid arthritis_Homo sapiens_hsa053230.75924130
45Pyrimidine metabolism_Homo sapiens_hsa002400.75579173
46Autoimmune thyroid disease_Homo sapiens_hsa053200.75253454
47Purine metabolism_Homo sapiens_hsa002300.73054873
48Histidine metabolism_Homo sapiens_hsa003400.67509968
49Allograft rejection_Homo sapiens_hsa053300.66457105
50RNA transport_Homo sapiens_hsa030130.66109131
51Alcoholism_Homo sapiens_hsa050340.63681298
52Retinol metabolism_Homo sapiens_hsa008300.61727867
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60590886
54Metabolic pathways_Homo sapiens_hsa011000.60024829
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59221429
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58297230
57Phototransduction_Homo sapiens_hsa047440.56601756
58Base excision repair_Homo sapiens_hsa034100.52791745
59Phagosome_Homo sapiens_hsa041450.51585072
60Chemical carcinogenesis_Homo sapiens_hsa052040.51250620
61Linoleic acid metabolism_Homo sapiens_hsa005910.51218111
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.51071478
63Type I diabetes mellitus_Homo sapiens_hsa049400.49191515
64Amphetamine addiction_Homo sapiens_hsa050310.44304991
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43696315
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43544671
67Gap junction_Homo sapiens_hsa045400.41538487
68Epstein-Barr virus infection_Homo sapiens_hsa051690.40957094
69Starch and sucrose metabolism_Homo sapiens_hsa005000.40319177
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40280667
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39033120
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38721559
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37920547
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37841107
75Basal cell carcinoma_Homo sapiens_hsa052170.37756535
76Folate biosynthesis_Homo sapiens_hsa007900.37161436
77Salmonella infection_Homo sapiens_hsa051320.36356839
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35299054
79Olfactory transduction_Homo sapiens_hsa047400.34684311
80Basal transcription factors_Homo sapiens_hsa030220.33979225
81Cocaine addiction_Homo sapiens_hsa050300.33522025
82Taste transduction_Homo sapiens_hsa047420.32635047
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32627882
84Asthma_Homo sapiens_hsa053100.32343333
85ABC transporters_Homo sapiens_hsa020100.31883480
86N-Glycan biosynthesis_Homo sapiens_hsa005100.30247527
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29768726
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28547085
89T cell receptor signaling pathway_Homo sapiens_hsa046600.27247890
90Sulfur relay system_Homo sapiens_hsa041220.24574577
91Arachidonic acid metabolism_Homo sapiens_hsa005900.24130483
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23902449
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21997753
94Malaria_Homo sapiens_hsa051440.20994471
95Synaptic vesicle cycle_Homo sapiens_hsa047210.20837986
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.18922537
97Glutathione metabolism_Homo sapiens_hsa004800.18378099
98Serotonergic synapse_Homo sapiens_hsa047260.17500875
99Fatty acid metabolism_Homo sapiens_hsa012120.16757142
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16470064

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »