RNF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.68066485
2Golgi transport vesicle coating (GO:0048200)5.68066485
3NADH metabolic process (GO:0006734)3.91645649
4succinate metabolic process (GO:0006105)3.85937331
5protein localization to endosome (GO:0036010)3.79196096
6desmosome organization (GO:0002934)3.60605740
7positive regulation of vesicle fusion (GO:0031340)3.60307164
8tricarboxylic acid cycle (GO:0006099)3.51623174
9oxaloacetate metabolic process (GO:0006107)3.51196788
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.46213947
11retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.44710822
12macroautophagy (GO:0016236)3.42380716
13COPII vesicle coating (GO:0048208)3.35859575
14regulation of interferon-beta biosynthetic process (GO:0045357)3.29893314
15regulation of type B pancreatic cell apoptotic process (GO:2000674)3.28522990
16protein maturation by protein folding (GO:0022417)3.22774033
17hepatocyte apoptotic process (GO:0097284)3.22486265
18regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.20806610
19hemidesmosome assembly (GO:0031581)3.11099050
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.08022502
21transferrin transport (GO:0033572)3.07981547
22sphingosine metabolic process (GO:0006670)3.07757948
23nuclear pore complex assembly (GO:0051292)3.06469132
24definitive hemopoiesis (GO:0060216)3.04662580
25regulation of vitamin D biosynthetic process (GO:0060556)3.04285550
26trivalent inorganic cation transport (GO:0072512)3.01857246
27ferric iron transport (GO:0015682)3.01857246
28protein retention in ER lumen (GO:0006621)3.00312241
29positive regulation of interferon-alpha production (GO:0032727)2.99787049
30lysine metabolic process (GO:0006553)2.97578005
31lysine catabolic process (GO:0006554)2.97578005
32membrane raft organization (GO:0031579)2.97268113
33positive regulation of macroautophagy (GO:0016239)2.92515646
34G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.92258594
35intestinal epithelial cell development (GO:0060576)2.91498326
36negative regulation of protein localization to plasma membrane (GO:1903077)2.91494373
37energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.91232029
38ATP hydrolysis coupled proton transport (GO:0015991)2.91232029
39hypotonic response (GO:0006971)2.90258806
40positive regulation of nitric-oxide synthase activity (GO:0051000)2.84530802
41regulation of glucocorticoid metabolic process (GO:0031943)2.84431005
42tricarboxylic acid metabolic process (GO:0072350)2.82935806
43regulation of interferon-alpha production (GO:0032647)2.80875698
44valine metabolic process (GO:0006573)2.79724093
45iron ion import (GO:0097286)2.79541624
46ER to Golgi vesicle-mediated transport (GO:0006888)2.77046885
47vesicle coating (GO:0006901)2.76405559
48negative regulation of alcohol biosynthetic process (GO:1902931)2.76298473
49sequestering of metal ion (GO:0051238)2.75971966
50regulation of glucokinase activity (GO:0033131)2.75869405
51regulation of hexokinase activity (GO:1903299)2.75869405
52protein targeting to Golgi (GO:0000042)2.71582754
53regulation of transforming growth factor beta1 production (GO:0032908)2.70720753
54insulin secretion (GO:0030073)2.69819859
55phagosome maturation (GO:0090382)2.69538395
56cellular response to arsenic-containing substance (GO:0071243)2.69004102
57positive regulation of glycolytic process (GO:0045821)2.67839118
58diol metabolic process (GO:0034311)2.67492020
59cell adhesion mediated by integrin (GO:0033627)2.66721294
60drug transmembrane transport (GO:0006855)2.65076014
61glycoside metabolic process (GO:0016137)2.64812583
62regulation of synaptic vesicle exocytosis (GO:2000300)2.62924607
63signal peptide processing (GO:0006465)2.61939049
64early endosome to late endosome transport (GO:0045022)2.60907300
65negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.60051189
66positive regulation of protein autophosphorylation (GO:0031954)2.59303642
67histamine secretion (GO:0001821)2.58820584
68peptide hormone processing (GO:0016486)2.58688876
69regulation of protein localization to plasma membrane (GO:1903076)2.57880631
70Golgi organization (GO:0007030)2.56811047
71positive regulation of cardiac muscle hypertrophy (GO:0010613)2.55785479
72positive regulation of muscle hypertrophy (GO:0014742)2.55785479
73N-acetylneuraminate metabolic process (GO:0006054)2.55541093
74intra-Golgi vesicle-mediated transport (GO:0006891)2.53735604
75establishment of protein localization to Golgi (GO:0072600)2.53547770
762-oxoglutarate metabolic process (GO:0006103)2.52106503
77glycosphingolipid catabolic process (GO:0046479)2.51696966
78positive regulation of glycoprotein metabolic process (GO:1903020)2.51157657
79regulation of acyl-CoA biosynthetic process (GO:0050812)2.48447548
80regulation of establishment of protein localization to plasma membrane (GO:0090003)2.47905724
81response to arsenic-containing substance (GO:0046685)2.47563019
82negative regulation of hormone metabolic process (GO:0032351)2.47180455
83negative regulation of hormone biosynthetic process (GO:0032353)2.47180455
84positive regulation of keratinocyte differentiation (GO:0045618)2.47091262
85regulation of vitamin metabolic process (GO:0030656)2.46441974
86oligosaccharide catabolic process (GO:0009313)2.45898642
87cellular response to thyroid hormone stimulus (GO:0097067)2.44226654
88regulation of T-helper 1 cell differentiation (GO:0045625)2.43563881
89positive regulation of macrophage differentiation (GO:0045651)2.43521990
90ER overload response (GO:0006983)2.42713462
91regulation of Golgi to plasma membrane protein transport (GO:0042996)2.41505393
92positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.41213422
93antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.41061115
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.41061115
95deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.40790809
96mammary gland epithelial cell proliferation (GO:0033598)2.40482152
97negative regulation of NF-kappaB import into nucleus (GO:0042347)2.40362009
98regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.39105437
99nuclear pore organization (GO:0006999)2.38544951
100negative regulation of type 2 immune response (GO:0002829)2.38444367
101Golgi to plasma membrane protein transport (GO:0043001)2.38429085
102response to thyroid hormone (GO:0097066)2.38191297
103positive regulation of insulin receptor signaling pathway (GO:0046628)2.37953622
104skin morphogenesis (GO:0043589)2.36428585
105negative regulation of interleukin-17 production (GO:0032700)2.35708552
106activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.35600137
107pore complex assembly (GO:0046931)2.34459726
108antigen processing and presentation of endogenous antigen (GO:0019883)2.34016288
109regulation of coenzyme metabolic process (GO:0051196)2.33789939
110regulation of cofactor metabolic process (GO:0051193)2.33789939
111negative regulation of acute inflammatory response (GO:0002674)2.33490309
112mitotic sister chromatid cohesion (GO:0007064)2.32695733
113pH reduction (GO:0045851)2.32682183
114protein localization to Golgi apparatus (GO:0034067)2.32675805
115negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.31274334
116negative regulation of calcium ion transmembrane transport (GO:1903170)2.31274334
117retrograde transport, vesicle recycling within Golgi (GO:0000301)2.30670091
118regulation of early endosome to late endosome transport (GO:2000641)2.30364223
119regulation of interferon-beta production (GO:0032648)2.29895201
120sphingoid metabolic process (GO:0046519)2.29283310
121regulation of histone H3-K27 methylation (GO:0061085)2.28764820
122glycolipid catabolic process (GO:0019377)2.28259844
123detection of calcium ion (GO:0005513)2.27884541
124ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.27568196
125positive regulation of response to nutrient levels (GO:0032109)2.25933204
126positive regulation of response to extracellular stimulus (GO:0032106)2.25933204
127toxin metabolic process (GO:0009404)2.25772250
128regulation of synaptic vesicle transport (GO:1902803)2.25651445
129negative regulation of anoikis (GO:2000811)2.25622987
130surfactant homeostasis (GO:0043129)2.25575782
131positive regulation of autophagy (GO:0010508)2.25213308
132positive regulation of cellular amide metabolic process (GO:0034250)2.25020217
133serotonin metabolic process (GO:0042428)2.24927160
134response to hydroperoxide (GO:0033194)2.24497693
135ribosome assembly (GO:0042255)2.23400521
136carnitine metabolic process (GO:0009437)2.23271924
137necroptotic process (GO:0070266)2.23052156
138negative regulation of dendrite morphogenesis (GO:0050774)2.22448356
139negative regulation of T-helper cell differentiation (GO:0045623)2.21778814
140negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.21778814
141negative regulation of glycoprotein biosynthetic process (GO:0010561)2.21551125
142primary amino compound metabolic process (GO:1901160)2.21394500
143sphingomyelin metabolic process (GO:0006684)2.20738092
144negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.20308138
145alkaloid metabolic process (GO:0009820)2.20007534
146negative regulation of cation channel activity (GO:2001258)2.19646776
147eosinophil chemotaxis (GO:0048245)2.19551196
148intracellular pH reduction (GO:0051452)2.19549931
149regulation of cholesterol homeostasis (GO:2000188)2.19063338
150regulation of steroid hormone biosynthetic process (GO:0090030)2.18332734
151cell-substrate junction assembly (GO:0007044)2.18171231
152lactate metabolic process (GO:0006089)2.17992451
153negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.17528002
154fatty acid homeostasis (GO:0055089)2.17374746
155histone H2B ubiquitination (GO:0033523)2.17336442
156negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.16884814
157serine transport (GO:0032329)2.16318037
158phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.16282428
159positive regulation of nuclease activity (GO:0032075)2.16253848
160regulation of sodium ion transmembrane transporter activity (GO:2000649)2.16232177
161antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.15986771
162neutrophil activation involved in immune response (GO:0002283)2.15236854
163response to peptidoglycan (GO:0032494)2.14940590
164energy homeostasis (GO:0097009)2.14096899
165regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.13572380
166endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.13469861
167positive regulation of fatty acid biosynthetic process (GO:0045723)2.13136028
168inositol phosphate catabolic process (GO:0071545)2.13102925
169glutamate secretion (GO:0014047)2.12669791
170Golgi to plasma membrane transport (GO:0006893)2.12294377
171positive regulation of glycoprotein biosynthetic process (GO:0010560)2.12230548
172Golgi vesicle transport (GO:0048193)2.12082793
173regulation of clathrin-mediated endocytosis (GO:2000369)2.11750314
174cellular response to topologically incorrect protein (GO:0035967)2.11138966
175Golgi to endosome transport (GO:0006895)2.11063494
176cellular response to unfolded protein (GO:0034620)2.10314737
177cellular response to exogenous dsRNA (GO:0071360)2.09818662
178regulation of T-helper 2 cell differentiation (GO:0045628)2.09577749
179endocrine pancreas development (GO:0031018)2.09451622
180ER-nucleus signaling pathway (GO:0006984)2.09211319
181inositol phosphate dephosphorylation (GO:0046855)2.09050197
182phosphorylated carbohydrate dephosphorylation (GO:0046838)2.09050197
183endoplasmic reticulum unfolded protein response (GO:0030968)2.08930294
184chaperone mediated protein folding requiring cofactor (GO:0051085)2.07314215
185gluconeogenesis (GO:0006094)2.07176161
186cellular response to ethanol (GO:0071361)2.06549417
187cellular response to nutrient (GO:0031670)2.06333361
188plasma membrane repair (GO:0001778)2.03237586
189regulation of insulin secretion (GO:0050796)2.03209664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.58353176
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.26545909
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.03178133
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.95886989
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89100965
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.75034719
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.64613584
8GATA1_22025678_ChIP-Seq_K562_Human2.61902481
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47142567
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.42767152
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.29454976
12* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21105264
13* LXR_22158963_ChIP-Seq_LIVER_Mouse2.05548591
14SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.04081810
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.02974451
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.02072941
17SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.01806603
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.01806603
19IRF8_21731497_ChIP-ChIP_J774_Mouse1.99046580
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.97954044
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.94679026
22NRF2_20460467_ChIP-Seq_MEFs_Mouse1.91029144
23NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.91029144
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77399474
25ZNF263_19887448_ChIP-Seq_K562_Human1.71068881
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71016155
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68562539
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67336733
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66426960
30CLOCK_20551151_ChIP-Seq_293T_Human1.65811946
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.64095561
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.64002649
33BCAT_22108803_ChIP-Seq_LS180_Human1.60310009
34* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60249869
35* MYB_26560356_Chip-Seq_TH2_Human1.50098691
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49748578
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49382901
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.48721989
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46313208
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42488324
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.42345864
42BRD4_25478319_ChIP-Seq_HGPS_Human1.42255220
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41910353
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40185124
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40007547
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37004903
47SOX2_20726797_ChIP-Seq_SW620_Human1.36833035
48MYB_26560356_Chip-Seq_TH1_Human1.36520205
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36452739
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36399280
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35207833
52SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33463075
53SPI1_23547873_ChIP-Seq_NB4_Human1.33123332
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32095673
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31848644
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31794323
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30941818
58* GATA3_26560356_Chip-Seq_TH2_Human1.30205518
59ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28006396
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25152327
61RXR_22108803_ChIP-Seq_LS180_Human1.24323423
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23293438
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21228557
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19136044
65NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18657526
66GATA3_27048872_Chip-Seq_THYMUS_Human1.18192643
67* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17758457
68VDR_22108803_ChIP-Seq_LS180_Human1.17586720
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.17080669
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14415161
71AR_21909140_ChIP-Seq_LNCAP_Human1.13922213
72* CHD1_26751641_Chip-Seq_LNCaP_Human1.13446232
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12885599
74* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12883879
75ELF5_23300383_ChIP-Seq_T47D_Human1.12067071
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11982714
77SMAD4_21799915_ChIP-Seq_A2780_Human1.10421263
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.09734764
79FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08961879
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08626617
81GBX2_23144817_ChIP-Seq_PC3_Human1.08383916
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08184504
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08103158
84* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07963466
85FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07461883
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06960552
87SCL_19346495_ChIP-Seq_HPC-7_Human1.06090451
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05965490
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.05961222
90SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05100899
91ESR1_21235772_ChIP-Seq_MCF-7_Human1.04984440
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04772428
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04227144
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02912213
95EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.02570637
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02416839
97* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02382560
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01952789
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01878870
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01441015
101* RUNX1_22412390_ChIP-Seq_EML_Mouse1.01186268
102JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00862898
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00505943
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99817419
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98997575
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98601119
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97990806
108EP300_21415370_ChIP-Seq_HL-1_Mouse0.97656849
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97613770
110WT1_19549856_ChIP-ChIP_CCG9911_Human0.97406049
111STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97375510
112SPI1_23127762_ChIP-Seq_K562_Human0.97318498
113CBP_20019798_ChIP-Seq_JUKART_Human0.95864922
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95864922
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95410228
116TAF15_26573619_Chip-Seq_HEK293_Human0.95144593
117HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94992906
118ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94737725
119* DCP1A_22483619_ChIP-Seq_HELA_Human0.94167507
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93735883
121GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92667814
122CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91594310
123FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91556286
124CJUN_26792858_Chip-Seq_BT549_Human0.91373150
125RUNX_20019798_ChIP-Seq_JUKART_Human0.91282440
126GATA3_24758297_ChIP-Seq_MCF-7_Human0.90918369
127ATF3_27146783_Chip-Seq_COLON_Human0.90857866
128TP63_23658742_ChIP-Seq_EP156T_Human0.90621160
129TCF4_22108803_ChIP-Seq_LS180_Human0.88738244
130CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88456474
131HTT_18923047_ChIP-ChIP_STHdh_Human0.87844829
132TP53_16413492_ChIP-PET_HCT116_Human0.87219291
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86960750
134TP53_18474530_ChIP-ChIP_U2OS_Human0.86398041
135FOXA2_19822575_ChIP-Seq_HepG2_Human0.86337105
136FLI1_21867929_ChIP-Seq_TH2_Mouse0.85661564
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84871043
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83416317
139GATA2_19941826_ChIP-Seq_K562_Human0.82590295
140* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82440013
141RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82346605
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.81917858
143FLI1_27457419_Chip-Seq_LIVER_Mouse0.81616677
144ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81542651
145GATA3_26560356_Chip-Seq_TH1_Human0.81147785
146PU_27001747_Chip-Seq_BMDM_Mouse0.80658079
147AR_20517297_ChIP-Seq_VCAP_Human0.80341149
148VDR_24787735_ChIP-Seq_THP-1_Human0.80279527
149GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80245994
150LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78818365
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78619521
152TFEB_21752829_ChIP-Seq_HELA_Human0.78612259
153PIAS1_25552417_ChIP-Seq_VCAP_Human0.75993233
154PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.75936182
155SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.75061548
156TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.74349973
157CDX2_22108803_ChIP-Seq_LS180_Human0.73648484
158PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73349383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.71412811
2MP0003195_calcinosis3.19941406
3MP0000013_abnormal_adipose_tissue3.04115631
4MP0010234_abnormal_vibrissa_follicle2.96034227
5MP0009780_abnormal_chondrocyte_physiolo2.77216432
6MP0002877_abnormal_melanocyte_morpholog2.75958550
7MP0010352_gastrointestinal_tract_polyps2.72561348
8MP0002909_abnormal_adrenal_gland2.59733014
9MP0005451_abnormal_body_composition2.52461759
10MP0010386_abnormal_urinary_bladder2.43906468
11MP0002139_abnormal_hepatobiliary_system2.40395330
12MP0002166_altered_tumor_susceptibility2.39419443
13MP0004043_abnormal_pH_regulation2.37594209
14MP0010678_abnormal_skin_adnexa2.22939685
15MP0003252_abnormal_bile_duct2.18734238
16MP0005058_abnormal_lysosome_morphology2.03992884
17MP0003656_abnormal_erythrocyte_physiolo2.03356510
18MP0003183_abnormal_peptide_metabolism2.00260613
19MP0002693_abnormal_pancreas_physiology1.96882268
20MP0005360_urolithiasis1.96046808
21MP0003879_abnormal_hair_cell1.95670704
22MP0002009_preneoplasia1.92302140
23MP0002876_abnormal_thyroid_physiology1.91022682
24MP0003763_abnormal_thymus_physiology1.86829244
25MP0005365_abnormal_bile_salt1.85813364
26MP0003453_abnormal_keratinocyte_physiol1.84585130
27MP0002006_tumorigenesis1.82733566
28MP0001765_abnormal_ion_homeostasis1.80896673
29MP0004130_abnormal_muscle_cell1.78070133
30MP0001944_abnormal_pancreas_morphology1.76147443
31MP0008057_abnormal_DNA_replication1.68951433
32MP0000383_abnormal_hair_follicle1.66514678
33MP0003950_abnormal_plasma_membrane1.65218970
34MP0008875_abnormal_xenobiotic_pharmacok1.64285891
35MP0004381_abnormal_hair_follicle1.56315453
36MP0003300_gastrointestinal_ulcer1.55940132
37MP0003091_abnormal_cell_migration1.53477260
38MP0005332_abnormal_amino_acid1.52802334
39MP0005084_abnormal_gallbladder_morpholo1.50757869
40MP0004036_abnormal_muscle_relaxation1.49244381
41MP0002078_abnormal_glucose_homeostasis1.47616069
42MP0003172_abnormal_lysosome_physiology1.46212452
43MP0005535_abnormal_body_temperature1.45565899
44MP0005220_abnormal_exocrine_pancreas1.42886202
45MP0008260_abnormal_autophagy1.42848201
46MP0009643_abnormal_urine_homeostasis1.40915068
47MP0005310_abnormal_salivary_gland1.40789257
48MP0005085_abnormal_gallbladder_physiolo1.39914361
49MP0000427_abnormal_hair_cycle1.35759640
50MP0000749_muscle_degeneration1.33845062
51MP0001216_abnormal_epidermal_layer1.32269826
52MP0003646_muscle_fatigue1.31929926
53MP0003329_amyloid_beta_deposits1.31701201
54MP0005636_abnormal_mineral_homeostasis1.31017816
55MP0004782_abnormal_surfactant_physiolog1.30704879
56MP0009046_muscle_twitch1.30145215
57MP0008004_abnormal_stomach_pH1.29375167
58MP0010329_abnormal_lipoprotein_level1.27909881
59MP0004264_abnormal_extraembryonic_tissu1.27729454
60MP0002060_abnormal_skin_morphology1.27527224
61MP0003045_fibrosis1.26491823
62MP0000685_abnormal_immune_system1.23990588
63MP0003828_pulmonary_edema1.23931845
64MP0010155_abnormal_intestine_physiology1.23820826
65MP0002796_impaired_skin_barrier1.21963740
66MP0003724_increased_susceptibility_to1.21225581
67MP0002332_abnormal_exercise_endurance1.19416168
68MP0004947_skin_inflammation1.18367633
69MP0004084_abnormal_cardiac_muscle1.17542137
70MP0000604_amyloidosis1.15669817
71MP0003303_peritoneal_inflammation1.15441441
72MP0001800_abnormal_humoral_immune1.14965085
73MP0004808_abnormal_hematopoietic_stem1.14080849
74MP0001835_abnormal_antigen_presentation1.12437973
75MP0009785_altered_susceptibility_to1.12317681
76MP0002396_abnormal_hematopoietic_system1.12026537
77MP0002723_abnormal_immune_serum1.11760104
78MP0005621_abnormal_cell_physiology1.11638217
79MP0002452_abnormal_antigen_presenting1.11408717
80MP0003436_decreased_susceptibility_to1.10061205
81MP0005319_abnormal_enzyme/_coenzyme1.09681632
82MP0001661_extended_life_span1.08920172
83MP0001501_abnormal_sleep_pattern1.07894457
84MP0000465_gastrointestinal_hemorrhage1.07566106
85MP0002928_abnormal_bile_duct1.06125392
86MP0003448_altered_tumor_morphology1.04909264
87MP0000003_abnormal_adipose_tissue1.04395471
88MP0006036_abnormal_mitochondrial_physio1.04390666
89MP0005584_abnormal_enzyme/coenzyme_acti1.03721342
90MP0001756_abnormal_urination1.03595142
91MP0002398_abnormal_bone_marrow1.03333067
92MP0005076_abnormal_cell_differentiation1.02757428
93MP0001533_abnormal_skeleton_physiology1.01567195
94MP0005075_abnormal_melanosome_morpholog1.00686965
95MP0002420_abnormal_adaptive_immunity0.99876811
96MP0001819_abnormal_immune_cell0.99619442
97MP0000858_altered_metastatic_potential0.99459270
98MP0000609_abnormal_liver_physiology0.98513765
99MP0005166_decreased_susceptibility_to0.97654117
100MP0000230_abnormal_systemic_arterial0.97501792
101MP0005379_endocrine/exocrine_gland_phen0.97391446
102MP0001191_abnormal_skin_condition0.97289175
103MP0009764_decreased_sensitivity_to0.97226013
104MP0008469_abnormal_protein_level0.96371862
105MP0010307_abnormal_tumor_latency0.95462936
106MP0002118_abnormal_lipid_homeostasis0.95404704
107MP0000751_myopathy0.95299278
108MP0002138_abnormal_hepatobiliary_system0.94501431
109MP0001845_abnormal_inflammatory_respons0.94443252
110MP0002419_abnormal_innate_immunity0.92172432
111MP0005000_abnormal_immune_tolerance0.89358711
112MP0003191_abnormal_cellular_cholesterol0.88824534
113MP0009333_abnormal_splenocyte_physiolog0.88620387
114MP0005448_abnormal_energy_balance0.88600035
115MP0001851_eye_inflammation0.88163545
116MP0009384_cardiac_valve_regurgitation0.86462079
117MP0008438_abnormal_cutaneous_collagen0.86322756
118MP0004147_increased_porphyrin_level0.86076545
119MP0000015_abnormal_ear_pigmentation0.86001232
120MP0001727_abnormal_embryo_implantation0.85834215
121MP0002998_abnormal_bone_remodeling0.84523341
122MP0002971_abnormal_brown_adipose0.84177385
123MP0003953_abnormal_hormone_level0.84004401
124MP0003705_abnormal_hypodermis_morpholog0.83424419
125MP0002168_other_aberrant_phenotype0.83061880
126MP0005384_cellular_phenotype0.83048435
127MP0002722_abnormal_immune_system0.82474460
128MP0005025_abnormal_response_to0.82370034
129MP0001666_abnormal_nutrient_absorption0.82161685
130MP0001243_abnormal_dermal_layer0.81905100
131MP0005165_increased_susceptibility_to0.81803764
132MP0000377_abnormal_hair_follicle0.81796220
133MP0005464_abnormal_platelet_physiology0.81766855
134MP0004185_abnormal_adipocyte_glucose0.81561370
135MP0001764_abnormal_homeostasis0.81382213
136MP0003075_altered_response_to0.81354515
137MP0002405_respiratory_system_inflammati0.81024428
138MP0009840_abnormal_foam_cell0.80699480
139MP0000689_abnormal_spleen_morphology0.80597781
140MP0000716_abnormal_immune_system0.80123421
141MP0002896_abnormal_bone_mineralization0.80050982
142MP0006082_CNS_inflammation0.79930322
143MP0005671_abnormal_response_to0.79143994
144MP0004510_myositis0.78846190
145MP0006054_spinal_hemorrhage0.78411136
146MP0003566_abnormal_cell_adhesion0.77906913
147MP0005387_immune_system_phenotype0.77273313
148MP0001790_abnormal_immune_system0.77273313
149MP0004859_abnormal_synaptic_plasticity0.77184214
150MP0000371_diluted_coat_color0.76685452
151MP0002148_abnormal_hypersensitivity_rea0.75765692
152MP0004215_abnormal_myocardial_fiber0.74316722
153MP0005083_abnormal_biliary_tract0.73652815
154MP0008874_decreased_physiological_sensi0.73158710
155MP0005375_adipose_tissue_phenotype0.73017398
156MP0003868_abnormal_feces_composition0.71828150
157MP0005275_abnormal_skin_tensile0.71769946
158MP0006035_abnormal_mitochondrial_morpho0.71762487
159MP0003866_abnormal_defecation0.71601462
160MP0003283_abnormal_digestive_organ0.71568405

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)3.54164452
2Papillary thyroid carcinoma (HP:0002895)3.22336074
3Gout (HP:0001997)2.95511043
4Hyperinsulinemic hypoglycemia (HP:0000825)2.92147628
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.89876343
6Ketoacidosis (HP:0001993)2.84854959
7Hypoglycemic seizures (HP:0002173)2.82760474
8Osteolytic defects of the hand bones (HP:0009699)2.78499878
9Osteolytic defects of the phalanges of the hand (HP:0009771)2.78499878
10Oligomenorrhea (HP:0000876)2.77148058
11Hyperglycemia (HP:0003074)2.72959303
12Vacuolated lymphocytes (HP:0001922)2.70255838
13Generalized aminoaciduria (HP:0002909)2.68348498
14Dysostosis multiplex (HP:0000943)2.64065642
15Vertebral compression fractures (HP:0002953)2.62591701
16Abnormality of liposaccharide metabolism (HP:0010968)2.59526941
17Abnormality of glycosphingolipid metabolism (HP:0004343)2.59526941
18Abnormality of glycolipid metabolism (HP:0010969)2.59526941
19Thyroid carcinoma (HP:0002890)2.59192459
20Thick nail (HP:0001805)2.58859362
21Horizontal nystagmus (HP:0000666)2.48259772
22Symptomatic seizures (HP:0011145)2.45318821
23Fatigue (HP:0012378)2.44288449
24Visual hallucinations (HP:0002367)2.41815137
25Hypercortisolism (HP:0001578)2.38774653
26Myoglobinuria (HP:0002913)2.38616366
27Increased mean platelet volume (HP:0011877)2.36946017
28Onycholysis (HP:0001806)2.33818487
29Curly hair (HP:0002212)2.33684876
30Basal ganglia calcification (HP:0002135)2.29749494
31Abnormality of endocrine pancreas physiology (HP:0012093)2.28599685
32Abnormality of the pancreatic islet cells (HP:0006476)2.28599685
33Abnormal platelet volume (HP:0011876)2.27763564
34Milia (HP:0001056)2.27582753
35Abnormality of the intrinsic pathway (HP:0010989)2.27563885
36Autoamputation (HP:0001218)2.27510762
37Hypokinesia (HP:0002375)2.26649782
38Asymmetry of the thorax (HP:0001555)2.26048330
39Insulin-resistant diabetes mellitus (HP:0000831)2.23124225
40Increased cerebral lipofuscin (HP:0011813)2.22909518
41Late onset (HP:0003584)2.22582161
42Plantar hyperkeratosis (HP:0007556)2.21784849
43Mucopolysacchariduria (HP:0008155)2.20686135
44Urinary glycosaminoglycan excretion (HP:0003541)2.20686135
45Resting tremor (HP:0002322)2.19982305
46Dysmetric saccades (HP:0000641)2.19821284
47Acute hepatic failure (HP:0006554)2.18435459
48Abnormality of the common coagulation pathway (HP:0010990)2.18333500
49Testicular neoplasm (HP:0010788)2.17882839
50Short nail (HP:0001799)2.15533536
51Erythema (HP:0010783)2.15134875
52Ketosis (HP:0001946)2.14242895
53Focal motor seizures (HP:0011153)2.12498800
54Cardiovascular calcification (HP:0011915)2.12042045
55Petechiae (HP:0000967)2.11966576
56Sensorimotor neuropathy (HP:0007141)2.10467831
57Vascular calcification (HP:0004934)2.09115089
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.08627863
59Cutaneous melanoma (HP:0012056)2.08130731
60Hematochezia (HP:0002573)2.06278485
61Autoimmune hemolytic anemia (HP:0001890)2.04159208
62Micronodular cirrhosis (HP:0001413)2.03653706
63Neuroendocrine neoplasm (HP:0100634)2.02952720
64Abnormality of purine metabolism (HP:0004352)2.02017632
65Mitral stenosis (HP:0001718)2.01740425
66Malnutrition (HP:0004395)2.01674176
67Subacute progressive viral hepatitis (HP:0006572)2.01142143
68Myocardial infarction (HP:0001658)2.00861127
69Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00486199
70Abnormality of polysaccharide metabolism (HP:0011012)2.00486199
71Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00486199
72Alopecia of scalp (HP:0002293)1.98650997
73Eczematoid dermatitis (HP:0000976)1.98353149
74Chronic diarrhea (HP:0002028)1.96484866
75Absent frontal sinuses (HP:0002688)1.95644093
76Pheochromocytoma (HP:0002666)1.94141283
77Difficulty climbing stairs (HP:0003551)1.94050936
78Exercise-induced muscle cramps (HP:0003710)1.94050904
79Insidious onset (HP:0003587)1.93937500
80Termporal pattern (HP:0011008)1.93937500
81Abnormality of the basal ganglia (HP:0002134)1.93776192
82Atonic seizures (HP:0010819)1.93515415
83Palmoplantar hyperkeratosis (HP:0000972)1.92316383
84Abnormal glucose tolerance (HP:0001952)1.91379435
85Protuberant abdomen (HP:0001538)1.91026590
86Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.89898129
87Gingival bleeding (HP:0000225)1.89773465
88Xanthomatosis (HP:0000991)1.89127157
89Conjunctival hamartoma (HP:0100780)1.88921324
90Coarse hair (HP:0002208)1.88013981
91Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87511659
92Progressive neurologic deterioration (HP:0002344)1.85818265
93Abnormality of the distal phalanges of the toes (HP:0010182)1.85176856
94Global brain atrophy (HP:0002283)1.84052452
95Hypothermia (HP:0002045)1.83336994
96Palmar hyperkeratosis (HP:0010765)1.82955488
97Asymmetric septal hypertrophy (HP:0001670)1.82554379
98Abnormality of macrophages (HP:0004311)1.81919055
99Type I diabetes mellitus (HP:0100651)1.80137916
100Calf muscle hypertrophy (HP:0008981)1.79497392
101Overlapping toe (HP:0001845)1.79481512
102Interstitial pulmonary disease (HP:0006530)1.79193154
103Osteomyelitis (HP:0002754)1.79063765
104Abnormality of calcium-phosphate metabolism (HP:0100530)1.78051357
105Beaking of vertebral bodies (HP:0004568)1.77341151
106Prolonged bleeding time (HP:0003010)1.75945729
107Recurrent bacterial skin infections (HP:0005406)1.75838270
108Striae distensae (HP:0001065)1.75830038
109Lower limb hyperreflexia (HP:0002395)1.75636712
110Sparse lateral eyebrow (HP:0005338)1.74739198
111Abnormality of fatty-acid metabolism (HP:0004359)1.74624601
112Tetraparesis (HP:0002273)1.74052796
113Growth hormone excess (HP:0000845)1.71983739
114Anhidrosis (HP:0000970)1.71931748
115Increased connective tissue (HP:0009025)1.71329761
116Progressive visual loss (HP:0000529)1.70654402
117Slow saccadic eye movements (HP:0000514)1.69855138
118Progressive hearing impairment (HP:0001730)1.69026075
119Tongue fasciculations (HP:0001308)1.68122433
120Cheilitis (HP:0100825)1.67554108
121Prominent metopic ridge (HP:0005487)1.67366326
122Acanthocytosis (HP:0001927)1.66743312
123Abnormal rod and cone electroretinograms (HP:0008323)1.66517025
124Hepatic necrosis (HP:0002605)1.66437219
125Loss of speech (HP:0002371)1.66021732
126Viral hepatitis (HP:0006562)1.65663309
127Shoulder girdle muscle weakness (HP:0003547)1.65200976
128Hyperphosphatemia (HP:0002905)1.65092587
129Central scotoma (HP:0000603)1.65080900
130Abnormality of nail color (HP:0100643)1.64827375
131Recurrent abscess formation (HP:0002722)1.64051528
132Septate vagina (HP:0001153)1.63985520
133Glucose intolerance (HP:0000833)1.63310274
134Recurrent gram-negative bacterial infections (HP:0005420)1.63286746
135Entropion (HP:0000621)1.62249345
136Epileptic encephalopathy (HP:0200134)1.61908274
137Syringomyelia (HP:0003396)1.61867991
138Spinal cord lesions (HP:0100561)1.61867991
139Reduced subcutaneous adipose tissue (HP:0003758)1.61738975
140Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.61735280
141Nail dystrophy (HP:0008404)1.61481846
142Chronic otitis media (HP:0000389)1.61350383
143Hyperventilation (HP:0002883)1.61061468
144Abnormality of small intestinal villus morphology (HP:0011472)1.60710983
145Villous atrophy (HP:0011473)1.60710983
146Abnormality of glutamine family amino acid metabolism (HP:0010902)1.60686510
147Premature rupture of membranes (HP:0001788)1.60576280
148Unilateral renal agenesis (HP:0000122)1.60527427
149Cervical subluxation (HP:0003308)1.59735484
150Muscle fibrillation (HP:0010546)1.59622109
151Abnormal gallbladder morphology (HP:0012437)1.59068598
152Hypoventilation (HP:0002791)1.58967525
153Bundle branch block (HP:0011710)1.58442717
154Abnormal mitochondria in muscle tissue (HP:0008316)1.57870531
155Hyperparathyroidism (HP:0000843)1.57634195
156Absence seizures (HP:0002121)1.55655014
157Right ventricular cardiomyopathy (HP:0011663)1.55229494
158Pancreatitis (HP:0001733)1.52856694
159Menstrual irregularities (HP:0000858)1.51743073
160Hydroxyprolinuria (HP:0003080)1.51392584
161Abnormality of proline metabolism (HP:0010907)1.51392584
162Cholelithiasis (HP:0001081)1.51141353
163Esophageal neoplasm (HP:0100751)1.50838051
164Neoplasm of head and neck (HP:0012288)1.50838051
165Abnormality of dicarboxylic acid metabolism (HP:0010995)1.50595573
166Dicarboxylic aciduria (HP:0003215)1.50595573
167Abnormality of chloride homeostasis (HP:0011422)1.50584578
168Insulin resistance (HP:0000855)1.50516647
169Type II lissencephaly (HP:0007260)1.50069244
170Absent rod-and cone-mediated responses on ERG (HP:0007688)1.49757820
171Abnormality of monocarboxylic acid metabolism (HP:0010996)1.49594767
172Retinal atrophy (HP:0001105)1.49320913
173Conjugated hyperbilirubinemia (HP:0002908)1.49279072
174Abdominal distention (HP:0003270)1.48895853
175Biconcave vertebral bodies (HP:0004586)1.48314495
176Spinal canal stenosis (HP:0003416)1.48011303
177Pelvic girdle muscle weakness (HP:0003749)1.47920864

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.04139753
2RIPK43.63121240
3FRK3.47488843
4MST43.10598821
5CAMKK22.58895460
6INSRR2.47459171
7PDK42.44971814
8PDK32.44971814
9ARAF2.31263676
10TRIB32.17995503
11ERN12.13584034
12CASK1.98041349
13MAP3K141.91082364
14IRAK31.90118950
15MAP3K121.89451066
16BCKDK1.87738974
17MAP3K131.81107060
18BRD41.76755237
19EIF2AK11.76685182
20AKT31.76265031
21PRPF4B1.71277517
22STK241.68137060
23NTRK31.64745935
24PIM21.63664320
25MAP3K31.63047797
26FLT31.56937349
27FGFR31.46377115
28PDK21.44393336
29TTN1.42724159
30IRAK41.38883063
31STK31.36191981
32ERBB31.36189951
33JAK11.35149732
34ACVR1B1.34996249
35CDK121.30960075
36MYLK1.28859221
37BMPR21.24643008
38EPHA21.24267898
39PASK1.23388145
40CCNB11.22498797
41BRSK21.21843452
42NEK91.21061479
43SCYL21.19699099
44CAMKK11.19570092
45TRPM71.18721948
46CSF1R1.18191898
47WNK41.17172336
48MAP3K21.15789487
49PIK3CG1.14301236
50MELK1.10087358
51CDK191.08377250
52PRKD31.07121515
53TBK11.06853905
54BRAF1.05831515
55MARK31.04637541
56FER1.04148212
57TAOK11.02594621
58CDK61.02579933
59PLK21.02301335
60PKN21.02199656
61MAP2K71.01600909
62TSSK61.01566835
63TYK21.00786534
64NEK60.99979259
65IKBKB0.99458592
66BTK0.99258861
67DAPK20.99180522
68MAP3K10.96809307
69ABL20.94625127
70JAK30.93291105
71MUSK0.93132269
72PDGFRB0.91382024
73NLK0.91044640
74PDGFRA0.88634546
75PAK40.88266135
76IRAK10.85627771
77DAPK10.85279090
78TESK10.85253125
79STK380.84127041
80MET0.84071213
81STK100.82198277
82NEK10.81825957
83PTK2B0.81106156
84MAP2K30.80403934
85FGR0.80135046
86TGFBR20.79432764
87MAPK110.77450008
88NTRK10.77431793
89YES10.76999548
90GRK50.76818345
91CSK0.76411802
92MAP2K40.76320551
93RAF10.72820877
94STK38L0.71759543
95FGFR40.68343590
96JAK20.67805405
97MAP3K50.67204631
98PRKCH0.66350392
99PTK20.66231203
100PAK30.65572959
101TEC0.64655611
102SGK20.63373202
103LMTK20.62562600
104KIT0.62481799
105TXK0.62364928
106MAP3K40.61782460
107TIE10.61385362
108HCK0.61233638
109MAPKAPK30.60006890
110CHUK0.59687395
111PDK10.58891120
112SYK0.55765415
113SGK30.55228018
114MAP3K90.55160756
115FES0.54670264
116WNK10.54077967
117RET0.52874927
118MOS0.52520738
119EPHB10.51164272
120STK40.50032217
121IKBKE0.49978200
122PRKCE0.48909094
123RPS6KB10.48495785
124MAP2K10.47804343
125SIK30.46051521
126MAP3K70.44811901
127SIK10.44017890
128PTK60.43460509
129CDK90.43121121
130HIPK20.42494349
131EIF2AK30.41840163
132PDPK10.41136351
133ITK0.40716912
134RIPK10.40231207
135MAPK70.40126992
136ZAP700.40065773
137EPHA30.39571587
138EEF2K0.37415976
139WNK30.37222611
140LATS20.37181199
141MST1R0.36727630
142PIK3CA0.36319408
143KSR20.35363869
144PRKCQ0.32725750

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.44557887
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.43809115
3Synaptic vesicle cycle_Homo sapiens_hsa047212.92033980
4Collecting duct acid secretion_Homo sapiens_hsa049662.73921051
5Vibrio cholerae infection_Homo sapiens_hsa051102.33910759
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.19429508
7B cell receptor signaling pathway_Homo sapiens_hsa046621.85576199
8Type I diabetes mellitus_Homo sapiens_hsa049401.82221352
9mTOR signaling pathway_Homo sapiens_hsa041501.80082941
10Protein export_Homo sapiens_hsa030601.78336817
11Insulin secretion_Homo sapiens_hsa049111.77270480
12Rheumatoid arthritis_Homo sapiens_hsa053231.66282354
13Measles_Homo sapiens_hsa051621.61662436
14Non-small cell lung cancer_Homo sapiens_hsa052231.57229652
15Sulfur metabolism_Homo sapiens_hsa009201.56697867
16Thyroid cancer_Homo sapiens_hsa052161.56080439
17Amphetamine addiction_Homo sapiens_hsa050311.53055348
18Other glycan degradation_Homo sapiens_hsa005111.45324995
19Pancreatic cancer_Homo sapiens_hsa052121.44628271
20Toxoplasmosis_Homo sapiens_hsa051451.41320920
21Small cell lung cancer_Homo sapiens_hsa052221.39057834
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37488792
23Prostate cancer_Homo sapiens_hsa052151.35659682
24Hepatitis C_Homo sapiens_hsa051601.35280842
25Hepatitis B_Homo sapiens_hsa051611.35155541
26Lysosome_Homo sapiens_hsa041421.34713865
27Acute myeloid leukemia_Homo sapiens_hsa052211.31332168
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30156404
29Pyruvate metabolism_Homo sapiens_hsa006201.29796557
30Inositol phosphate metabolism_Homo sapiens_hsa005621.28955723
31Chronic myeloid leukemia_Homo sapiens_hsa052201.28757117
32Endometrial cancer_Homo sapiens_hsa052131.28057321
33Platelet activation_Homo sapiens_hsa046111.27044744
34Sphingolipid metabolism_Homo sapiens_hsa006001.26516587
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26266994
36T cell receptor signaling pathway_Homo sapiens_hsa046601.25985915
37Shigellosis_Homo sapiens_hsa051311.25489709
38Type II diabetes mellitus_Homo sapiens_hsa049301.22991891
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22672490
40Influenza A_Homo sapiens_hsa051641.18289980
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17959348
42Glucagon signaling pathway_Homo sapiens_hsa049221.16898123
43Legionellosis_Homo sapiens_hsa051341.15971504
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15740332
45Renal cell carcinoma_Homo sapiens_hsa052111.15341571
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.13904156
47Fatty acid degradation_Homo sapiens_hsa000711.13857667
48Tryptophan metabolism_Homo sapiens_hsa003801.10183746
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08968524
50FoxO signaling pathway_Homo sapiens_hsa040681.07748402
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05253590
52Phagosome_Homo sapiens_hsa041451.02706290
53Phototransduction_Homo sapiens_hsa047441.01788778
54Sphingolipid signaling pathway_Homo sapiens_hsa040711.01682671
55Propanoate metabolism_Homo sapiens_hsa006401.01418731
56Cocaine addiction_Homo sapiens_hsa050301.00939138
57VEGF signaling pathway_Homo sapiens_hsa043700.98838177
58Long-term potentiation_Homo sapiens_hsa047200.98698524
59Carbon metabolism_Homo sapiens_hsa012000.97932085
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96471820
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96129019
62Fatty acid biosynthesis_Homo sapiens_hsa000610.94912743
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.94890595
64Starch and sucrose metabolism_Homo sapiens_hsa005000.93588105
65Apoptosis_Homo sapiens_hsa042100.93563836
66Proteoglycans in cancer_Homo sapiens_hsa052050.93146749
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92360627
68Tuberculosis_Homo sapiens_hsa051520.92118170
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87373720
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.87300291
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86332939
72Fructose and mannose metabolism_Homo sapiens_hsa000510.85584745
73Glioma_Homo sapiens_hsa052140.85401764
74Herpes simplex infection_Homo sapiens_hsa051680.83874732
75Regulation of autophagy_Homo sapiens_hsa041400.83577417
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83038527
77Thyroid hormone synthesis_Homo sapiens_hsa049180.82789071
78Viral carcinogenesis_Homo sapiens_hsa052030.81380459
79Dopaminergic synapse_Homo sapiens_hsa047280.80548798
80Endocytosis_Homo sapiens_hsa041440.80383049
81Circadian entrainment_Homo sapiens_hsa047130.79280413
82Galactose metabolism_Homo sapiens_hsa000520.78366472
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77449981
84Insulin resistance_Homo sapiens_hsa049310.77326945
85Olfactory transduction_Homo sapiens_hsa047400.77218895
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77161194
87Renin secretion_Homo sapiens_hsa049240.76554439
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.76329279
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76176224
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.76171247
91Focal adhesion_Homo sapiens_hsa045100.75840169
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75118309
93Phenylalanine metabolism_Homo sapiens_hsa003600.74196348
94HIF-1 signaling pathway_Homo sapiens_hsa040660.72164590
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71975082
96Selenocompound metabolism_Homo sapiens_hsa004500.71962594
97N-Glycan biosynthesis_Homo sapiens_hsa005100.71101225
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69937257
99Salivary secretion_Homo sapiens_hsa049700.69212612
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68804086
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68787767
102Amoebiasis_Homo sapiens_hsa051460.68301760
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67395650
104Dorso-ventral axis formation_Homo sapiens_hsa043200.66849851
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.66840006
106Pentose phosphate pathway_Homo sapiens_hsa000300.66391018
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66157330
108Hematopoietic cell lineage_Homo sapiens_hsa046400.65365362
109Bladder cancer_Homo sapiens_hsa052190.65010523
110GABAergic synapse_Homo sapiens_hsa047270.64091830
111Gastric acid secretion_Homo sapiens_hsa049710.63266262
112Cholinergic synapse_Homo sapiens_hsa047250.62993211
113AMPK signaling pathway_Homo sapiens_hsa041520.62509094
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61751659
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59904442
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59594548
117Morphine addiction_Homo sapiens_hsa050320.58873599
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58723236
119Pancreatic secretion_Homo sapiens_hsa049720.58659919
120Circadian rhythm_Homo sapiens_hsa047100.58606350
121TNF signaling pathway_Homo sapiens_hsa046680.57910100
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57018834
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56125969
124ErbB signaling pathway_Homo sapiens_hsa040120.55528274
125Fatty acid metabolism_Homo sapiens_hsa012120.55130506
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54762863
127Choline metabolism in cancer_Homo sapiens_hsa052310.54623082
128GnRH signaling pathway_Homo sapiens_hsa049120.54268799
129Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53910052
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53520178
131Leishmaniasis_Homo sapiens_hsa051400.53043826
132Peroxisome_Homo sapiens_hsa041460.52712093
133Osteoclast differentiation_Homo sapiens_hsa043800.52316489
134Serotonergic synapse_Homo sapiens_hsa047260.52209310
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52204606
136p53 signaling pathway_Homo sapiens_hsa041150.51388456
137Butanoate metabolism_Homo sapiens_hsa006500.51352616
138Chemokine signaling pathway_Homo sapiens_hsa040620.51329737
139Arginine biosynthesis_Homo sapiens_hsa002200.50835072
140Oxidative phosphorylation_Homo sapiens_hsa001900.50671320
141Adherens junction_Homo sapiens_hsa045200.50145919
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50047633
143Bile secretion_Homo sapiens_hsa049760.49195405
144Prolactin signaling pathway_Homo sapiens_hsa049170.49184942
145Insulin signaling pathway_Homo sapiens_hsa049100.48311798
146RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47547048
147African trypanosomiasis_Homo sapiens_hsa051430.46546765
148Biosynthesis of amino acids_Homo sapiens_hsa012300.46421473
149Histidine metabolism_Homo sapiens_hsa003400.45745134
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44505118
151PPAR signaling pathway_Homo sapiens_hsa033200.43574821
152cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42235930
153Oxytocin signaling pathway_Homo sapiens_hsa049210.41774984
154NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41358068
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40250540
156Nicotine addiction_Homo sapiens_hsa050330.39278671
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39172510
158Vascular smooth muscle contraction_Homo sapiens_hsa042700.37466551
159Calcium signaling pathway_Homo sapiens_hsa040200.37196770
160NF-kappa B signaling pathway_Homo sapiens_hsa040640.37143007
161Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36270272
162Antigen processing and presentation_Homo sapiens_hsa046120.35421257

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