RNF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.61571370
2axon ensheathment in central nervous system (GO:0032291)9.61571370
3fatty acid elongation (GO:0030497)6.16614177
4long-chain fatty acid biosynthetic process (GO:0042759)5.49129113
5ribosomal small subunit assembly (GO:0000028)5.26606769
6viral transcription (GO:0019083)5.16835514
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.15305926
8translational termination (GO:0006415)5.07108836
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.91117564
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.89495812
11ATP synthesis coupled proton transport (GO:0015986)4.89495812
12cotranslational protein targeting to membrane (GO:0006613)4.88343138
13protein targeting to ER (GO:0045047)4.80951893
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.76844948
15ensheathment of neurons (GO:0007272)4.65162568
16axon ensheathment (GO:0008366)4.65162568
17myelination (GO:0042552)4.64755690
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.61853519
19protein localization to endoplasmic reticulum (GO:0070972)4.55289481
20L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.53464576
21chaperone-mediated protein transport (GO:0072321)4.45437328
22translational elongation (GO:0006414)4.32904377
23cholesterol biosynthetic process (GO:0006695)4.31571067
24proteasome assembly (GO:0043248)4.19626311
25termination of RNA polymerase III transcription (GO:0006386)4.13548414
26transcription elongation from RNA polymerase III promoter (GO:0006385)4.13548414
27RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.12538397
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.12538397
29respiratory chain complex IV assembly (GO:0008535)4.05571976
30ribosomal large subunit biogenesis (GO:0042273)3.97982764
31sterol biosynthetic process (GO:0016126)3.94318960
32translation (GO:0006412)3.93074050
33maturation of SSU-rRNA (GO:0030490)3.91046511
34translational initiation (GO:0006413)3.90937818
35viral life cycle (GO:0019058)3.90603818
36establishment of mitochondrion localization (GO:0051654)3.89919096
37respiratory electron transport chain (GO:0022904)3.89703152
38sequestering of actin monomers (GO:0042989)3.89248417
39regulation of collateral sprouting (GO:0048670)3.87110962
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.87078380
41cellular protein complex disassembly (GO:0043624)3.85468784
42amino acid salvage (GO:0043102)3.85318085
43L-methionine salvage (GO:0071267)3.85318085
44L-methionine biosynthetic process (GO:0071265)3.85318085
45electron transport chain (GO:0022900)3.80079901
46cytochrome complex assembly (GO:0017004)3.72217808
477-methylguanosine mRNA capping (GO:0006370)3.70541015
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.68557599
497-methylguanosine RNA capping (GO:0009452)3.66801485
50RNA capping (GO:0036260)3.66801485
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.65621081
52isoprenoid biosynthetic process (GO:0008299)3.64376417
53GPI anchor biosynthetic process (GO:0006506)3.61459511
54cullin deneddylation (GO:0010388)3.58757209
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.55550155
56hydrogen ion transmembrane transport (GO:1902600)3.53463027
57ATP biosynthetic process (GO:0006754)3.52196862
58microtubule polymerization or depolymerization (GO:0031109)3.52160896
59protein-cofactor linkage (GO:0018065)3.51815275
60negative regulation of protein localization to cell surface (GO:2000009)3.50784361
61purine nucleoside triphosphate biosynthetic process (GO:0009145)3.44956098
62purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.43467739
63myelin maintenance (GO:0043217)3.42679984
64water-soluble vitamin biosynthetic process (GO:0042364)3.40707939
65NADH dehydrogenase complex assembly (GO:0010257)3.40597109
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40597109
67mitochondrial respiratory chain complex I assembly (GO:0032981)3.40597109
68substantia nigra development (GO:0021762)3.39548674
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36961169
70cellular component biogenesis (GO:0044085)3.35744254
71positive regulation of oligodendrocyte differentiation (GO:0048714)3.34566258
72peptidyl-histidine modification (GO:0018202)3.32090400
73positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.32039547
74mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.32039547
75GTP biosynthetic process (GO:0006183)3.30711155
76preassembly of GPI anchor in ER membrane (GO:0016254)3.29383214
77platelet dense granule organization (GO:0060155)3.29157256
78negative regulation of neurotransmitter transport (GO:0051589)3.28615831
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28029987
80negative regulation of ligase activity (GO:0051352)3.28029987
81inner mitochondrial membrane organization (GO:0007007)3.27886129
82protein targeting to mitochondrion (GO:0006626)3.25481297
83GPI anchor metabolic process (GO:0006505)3.25004595
84proton transport (GO:0015992)3.20710009
85protein targeting to membrane (GO:0006612)3.20304323
86DNA damage response, detection of DNA damage (GO:0042769)3.20181203
87pseudouridine synthesis (GO:0001522)3.19885280
88protein complex disassembly (GO:0043241)3.19312649
89intracellular protein transmembrane import (GO:0044743)3.18808097
90oxidative phosphorylation (GO:0006119)3.17873430
91establishment of protein localization to mitochondrion (GO:0072655)3.16644035
92protein deneddylation (GO:0000338)3.15550993
93protein complex biogenesis (GO:0070271)3.15487932
94chromatin remodeling at centromere (GO:0031055)3.13509753
95hydrogen transport (GO:0006818)3.13343022
96macromolecular complex disassembly (GO:0032984)3.09016634
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08976131
98mannosylation (GO:0097502)3.06641086
99ribonucleoside triphosphate biosynthetic process (GO:0009201)3.06107865
100regulation of cellular amino acid metabolic process (GO:0006521)3.05353179
101ribosomal small subunit biogenesis (GO:0042274)3.04600717
102guanosine-containing compound biosynthetic process (GO:1901070)3.03447294
103* protein neddylation (GO:0045116)3.02985557
104creatine metabolic process (GO:0006600)3.02966072
105rRNA modification (GO:0000154)3.02241161
106neurotransmitter uptake (GO:0001504)3.01676068
107tRNA processing (GO:0008033)3.00807994
108transcription elongation from RNA polymerase I promoter (GO:0006362)3.00157016
109regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.97229058
110oligodendrocyte differentiation (GO:0048709)2.96646108
111mitochondrial transport (GO:0006839)2.96373825
112amyloid precursor protein metabolic process (GO:0042982)2.95227512
113nuclear-transcribed mRNA catabolic process (GO:0000956)2.93036426
114protein localization to mitochondrion (GO:0070585)2.92800780
115anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91612280
116ribonucleoprotein complex biogenesis (GO:0022613)2.90016146
117CENP-A containing nucleosome assembly (GO:0034080)2.89939361
118pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89932898
119spliceosomal snRNP assembly (GO:0000387)2.89365759
120glycerophospholipid catabolic process (GO:0046475)2.88208565
121nucleoside triphosphate biosynthetic process (GO:0009142)2.83629659
122UTP biosynthetic process (GO:0006228)2.83348240
123mitochondrial respiratory chain complex assembly (GO:0033108)2.83166716
124rRNA processing (GO:0006364)2.80183920
125mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.78189527
126base-excision repair, AP site formation (GO:0006285)2.78009839
127regulation of mitochondrial translation (GO:0070129)2.77516320
128transcription from RNA polymerase I promoter (GO:0006360)2.76165630
129DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76069181
130mRNA catabolic process (GO:0006402)2.75876093
131negative regulation of neurotransmitter secretion (GO:0046929)2.75775169
132behavioral response to nicotine (GO:0035095)2.75633765
133magnesium ion transport (GO:0015693)2.73458695
134positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.72628812
135positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.72552027
136astrocyte development (GO:0014002)2.70329643
137intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.70043356
138signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.70043356
139blastocyst development (GO:0001824)2.69789330
140positive regulation of ligase activity (GO:0051351)2.69746226
141signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69208235
142signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69208235
143signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69208235
144termination of RNA polymerase I transcription (GO:0006363)2.67595420
145signal transduction involved in DNA damage checkpoint (GO:0072422)2.63798822
146signal transduction involved in DNA integrity checkpoint (GO:0072401)2.63798822
147tissue regeneration (GO:0042246)2.63555955
148histone H2B ubiquitination (GO:0033523)2.61470528
149signal transduction involved in cell cycle checkpoint (GO:0072395)2.60616325
150transcription elongation from RNA polymerase II promoter (GO:0006368)2.60228241
151negative regulation of JUN kinase activity (GO:0043508)2.59597518
152negative regulation of macroautophagy (GO:0016242)2.58753545
153regulation of cellular amine metabolic process (GO:0033238)2.57160573
154long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.56467742
155regulation of ubiquitin-protein transferase activity (GO:0051438)2.54068161
156GMP metabolic process (GO:0046037)2.53041953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.85073295
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.41712723
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.54356093
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.06997108
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.73224165
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.61270210
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.59416038
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.57836002
9* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.40548479
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.36592682
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.27927495
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02205703
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.61857229
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.28543473
15ZNF274_21170338_ChIP-Seq_K562_Hela2.26912375
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19008194
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11538837
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06646292
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06208423
20MYC_18940864_ChIP-ChIP_HL60_Human1.97298219
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94843988
22* VDR_23849224_ChIP-Seq_CD4+_Human1.94443268
23* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86387802
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85508835
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.84985490
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76261058
27VDR_22108803_ChIP-Seq_LS180_Human1.70554572
28DCP1A_22483619_ChIP-Seq_HELA_Human1.70019261
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.65563147
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61973549
31TAF15_26573619_Chip-Seq_HEK293_Human1.60174790
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59457135
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59346840
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.56991725
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54129241
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52990777
37XRN2_22483619_ChIP-Seq_HELA_Human1.52657043
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48318064
39ELK1_22589737_ChIP-Seq_MCF10A_Human1.44461894
40* ELK1_19687146_ChIP-ChIP_HELA_Human1.43381787
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43118377
42GABP_19822575_ChIP-Seq_HepG2_Human1.41212817
43IRF1_19129219_ChIP-ChIP_H3396_Human1.40047251
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38336144
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37579930
46IGF1R_20145208_ChIP-Seq_DFB_Human1.35871330
47* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35815288
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35461728
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31201387
50ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29217647
51CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.28494849
52TP53_22573176_ChIP-Seq_HFKS_Human1.27457405
53FOXP3_21729870_ChIP-Seq_TREG_Human1.27318015
54TTF2_22483619_ChIP-Seq_HELA_Human1.27185987
55NANOG_16153702_ChIP-ChIP_HESCs_Human1.24833842
56SOX17_20123909_ChIP-Seq_XEN_Mouse1.23887697
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21490267
58* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19304041
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18955149
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18914070
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18250762
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16706479
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16619561
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16619561
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16619561
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16119177
67FUS_26573619_Chip-Seq_HEK293_Human1.16077688
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13846504
69* P300_19829295_ChIP-Seq_ESCs_Human1.13747549
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11746961
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10954786
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09793413
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07360398
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.07254565
75* ER_23166858_ChIP-Seq_MCF-7_Human1.04380879
76EOMES_21245162_ChIP-Seq_HESCs_Human1.03742167
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03639075
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00526757
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00457567
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99402654
81GATA1_26923725_Chip-Seq_HPCs_Mouse0.96002946
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94316296
83MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94296873
84CBX2_27304074_Chip-Seq_ESCs_Mouse0.92390318
85EWS_26573619_Chip-Seq_HEK293_Human0.91746684
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.91716738
87HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91708460
88LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90087730
89RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88928454
90EZH2_22144423_ChIP-Seq_EOC_Human0.88850778
91* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87767554
92HTT_18923047_ChIP-ChIP_STHdh_Human0.87625153
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87297839
94NANOG_18692474_ChIP-Seq_MEFs_Mouse0.86249932
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.84654091
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84654091
97GBX2_23144817_ChIP-Seq_PC3_Human0.84275138
98AR_20517297_ChIP-Seq_VCAP_Human0.83074595
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80240383
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79443501
101CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.76422472
102POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76237437
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76195168
104CTBP1_25329375_ChIP-Seq_LNCAP_Human0.75970493
105KDM5A_27292631_Chip-Seq_BREAST_Human0.75931953
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75758569
107* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74993367
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.74837888
109NANOG_18555785_ChIP-Seq_MESCs_Mouse0.74806694
110GATA3_21878914_ChIP-Seq_MCF-7_Human0.74780132
111REST_19997604_ChIP-ChIP_NEURONS_Mouse0.74668709
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.74412795
113PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.74038559
114TAL1_26923725_Chip-Seq_HPCs_Mouse0.72019312
115EZH2_27304074_Chip-Seq_ESCs_Mouse0.72001295
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71911849
117NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71841579
118YY1_22570637_ChIP-Seq_MALME-3M_Human0.71361691
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.71257482
120NCOR_22424771_ChIP-Seq_293T_Human0.71186160
121SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70195748
122PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69879363
123KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69819234
124STAT1_20625510_ChIP-Seq_HELA_Human0.69767031
125* NANOG_19829295_ChIP-Seq_ESCs_Human0.69587533
126* SOX2_19829295_ChIP-Seq_ESCs_Human0.69587533
127SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.69440772
128FLI1_27457419_Chip-Seq_LIVER_Mouse0.69300265
129CTBP2_25329375_ChIP-Seq_LNCAP_Human0.69249266
130PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.67999141
131TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.67808481
132FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.67067287

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.94772537
2MP0001529_abnormal_vocalization3.59437534
3MP0006292_abnormal_olfactory_placode3.38916092
4MP0008260_abnormal_autophagy3.29526673
5MP0003880_abnormal_central_pattern3.13760598
6MP0003136_yellow_coat_color3.04733894
7MP0003950_abnormal_plasma_membrane3.00163343
8MP0001905_abnormal_dopamine_level3.00105280
9MP0003011_delayed_dark_adaptation2.74475053
10MP0004270_analgesia2.51451345
11MP0008789_abnormal_olfactory_epithelium2.39931046
12MP0002837_dystrophic_cardiac_calcinosis2.26810010
13MP0001485_abnormal_pinna_reflex2.17905447
14MP0004142_abnormal_muscle_tone2.17063628
15MP0005171_absent_coat_pigmentation2.14248953
16MP0004742_abnormal_vestibular_system2.10400234
17MP0002272_abnormal_nervous_system2.06659785
18MP0005410_abnormal_fertilization1.98283424
19MP0004043_abnormal_pH_regulation1.97523138
20MP0003718_maternal_effect1.94958650
21* MP0003186_abnormal_redox_activity1.90264616
22MP0005084_abnormal_gallbladder_morpholo1.89816867
23MP0003329_amyloid_beta_deposits1.88200899
24MP0005451_abnormal_body_composition1.83708655
25MP0010030_abnormal_orbit_morphology1.82902206
26MP0002734_abnormal_mechanical_nocicepti1.80943976
27MP0003634_abnormal_glial_cell1.76677463
28MP0003806_abnormal_nucleotide_metabolis1.76310219
29MP0000049_abnormal_middle_ear1.69429460
30MP0005423_abnormal_somatic_nervous1.69290002
31MP0000778_abnormal_nervous_system1.67553544
32MP0001486_abnormal_startle_reflex1.67446770
33MP0004885_abnormal_endolymph1.66600104
34MP0005499_abnormal_olfactory_system1.63669289
35MP0005394_taste/olfaction_phenotype1.63669289
36MP0002163_abnormal_gland_morphology1.62371951
37MP0003121_genomic_imprinting1.56092414
38MP0001293_anophthalmia1.55959751
39MP0003690_abnormal_glial_cell1.55553158
40MP0004133_heterotaxia1.51800626
41MP0002229_neurodegeneration1.50455871
42MP0005409_darkened_coat_color1.49235089
43MP0002938_white_spotting1.48977298
44MP0002064_seizures1.47091254
45MP0008932_abnormal_embryonic_tissue1.46339355
46MP0003938_abnormal_ear_development1.45773535
47MP0001661_extended_life_span1.45486160
48MP0004381_abnormal_hair_follicle1.43268104
49MP0000631_abnormal_neuroendocrine_gland1.42936803
50MP0001984_abnormal_olfaction1.42642707
51MP0001986_abnormal_taste_sensitivity1.40833478
52MP0001970_abnormal_pain_threshold1.36470690
53MP0003567_abnormal_fetal_cardiomyocyte1.35710239
54MP0000462_abnormal_digestive_system1.30407774
55MP0000372_irregular_coat_pigmentation1.27770551
56MP0002160_abnormal_reproductive_system1.25893634
57MP0003123_paternal_imprinting1.25579181
58MP0003632_abnormal_nervous_system1.25222612
59MP0003787_abnormal_imprinting1.22241802
60MP0002735_abnormal_chemical_nociception1.21211257
61MP0001968_abnormal_touch/_nociception1.20542738
62MP0001440_abnormal_grooming_behavior1.20042453
63MP0002234_abnormal_pharynx_morphology1.19475615
64MP0009379_abnormal_foot_pigmentation1.17757819
65MP0008872_abnormal_physiological_respon1.17170579
66MP0003646_muscle_fatigue1.16625762
67MP0006036_abnormal_mitochondrial_physio1.15776728
68MP0009046_muscle_twitch1.15635926
69MP0001963_abnormal_hearing_physiology1.14546464
70MP0003941_abnormal_skin_development1.14149718
71MP0002752_abnormal_somatic_nervous1.13798114
72MP0003937_abnormal_limbs/digits/tail_de1.13570911
73MP0005551_abnormal_eye_electrophysiolog1.12471336
74MP0005379_endocrine/exocrine_gland_phen1.11505189
75MP0000747_muscle_weakness1.11352918
76MP0002277_abnormal_respiratory_mucosa1.10402827
77MP0003693_abnormal_embryo_hatching1.10208973
78MP0002736_abnormal_nociception_after1.09186999
79MP0006276_abnormal_autonomic_nervous1.09053813
80MP0003195_calcinosis1.08454786
81MP0004147_increased_porphyrin_level1.07815418
82MP0001727_abnormal_embryo_implantation1.07806432
83MP0008007_abnormal_cellular_replicative1.06915780
84MP0004957_abnormal_blastocyst_morpholog1.06731299
85MP0005408_hypopigmentation1.04985507
86MP0000566_synostosis1.04984866
87MP0002233_abnormal_nose_morphology1.03949067
88MP0008877_abnormal_DNA_methylation1.03895117
89MP0002882_abnormal_neuron_morphology1.03409987
90MP0006072_abnormal_retinal_apoptosis1.02866331
91MP0002876_abnormal_thyroid_physiology1.02864687
92MP0008057_abnormal_DNA_replication1.02566795
93MP0009697_abnormal_copulation1.02465013
94MP0005389_reproductive_system_phenotype1.02345082
95MP0003315_abnormal_perineum_morphology1.02045948
96MP0000955_abnormal_spinal_cord1.01478842
97MP0002067_abnormal_sensory_capabilities1.00891793
98MP0000647_abnormal_sebaceous_gland1.00296769
99MP0004145_abnormal_muscle_electrophysio0.99044940
100MP0000762_abnormal_tongue_morphology0.98454793
101MP0001346_abnormal_lacrimal_gland0.98233582
102MP0003119_abnormal_digestive_system0.97788626
103MP0002066_abnormal_motor_capabilities/c0.97164501
104MP0002210_abnormal_sex_determination0.94327936
105MP0000749_muscle_degeneration0.93598772
106MP0008995_early_reproductive_senescence0.93382585
107MP0002733_abnormal_thermal_nociception0.92807778
108MP0001542_abnormal_bone_strength0.92509689
109MP0001286_abnormal_eye_development0.92061175
110MP0004036_abnormal_muscle_relaxation0.91726646
111MP0002557_abnormal_social/conspecific_i0.91473705
112MP0003755_abnormal_palate_morphology0.90687217
113MP0002572_abnormal_emotion/affect_behav0.90562907
114MP0009745_abnormal_behavioral_response0.90152978
115MP0000383_abnormal_hair_follicle0.89356870
116MP0009250_abnormal_appendicular_skeleto0.88527967
117MP0003631_nervous_system_phenotype0.88234743
118MP0004134_abnormal_chest_morphology0.88212960
119MP0000026_abnormal_inner_ear0.87797868
120MP0001764_abnormal_homeostasis0.87099578
121MP0001919_abnormal_reproductive_system0.86122258
122MP0002090_abnormal_vision0.86078963
123MP0005195_abnormal_posterior_eye0.85061796
124MP0006035_abnormal_mitochondrial_morpho0.84606600
125MP0008875_abnormal_xenobiotic_pharmacok0.84474201
126MP0004924_abnormal_behavior0.84183701
127MP0005386_behavior/neurological_phenoty0.84183701
128MP0003698_abnormal_male_reproductive0.84139590
129MP0002184_abnormal_innervation0.83696479
130MP0002282_abnormal_trachea_morphology0.83437685
131MP0002095_abnormal_skin_pigmentation0.82111794
132MP0005253_abnormal_eye_physiology0.81761247
133MP0003137_abnormal_impulse_conducting0.81527278
134MP0003890_abnormal_embryonic-extraembry0.80716442
135MP0005332_abnormal_amino_acid0.80614177
136MP0002751_abnormal_autonomic_nervous0.80250685
137MP0010386_abnormal_urinary_bladder0.79593215
138MP0005391_vision/eye_phenotype0.79333806
139MP0005645_abnormal_hypothalamus_physiol0.78821384
140MP0003786_premature_aging0.78580321
141MP0010678_abnormal_skin_adnexa0.77196003
142MP0000653_abnormal_sex_gland0.76530935
143MP0002102_abnormal_ear_morphology0.75981050
144MP0002638_abnormal_pupillary_reflex0.75114356
145MP0003635_abnormal_synaptic_transmissio0.74515683
146MP0001929_abnormal_gametogenesis0.73472467
147MP0002653_abnormal_ependyma_morphology0.72720979
148MP0001188_hyperpigmentation0.71522909
149MP0008058_abnormal_DNA_repair0.71119692
150MP0003122_maternal_imprinting0.70782562

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)5.48061258
2Acute necrotizing encephalopathy (HP:0006965)4.46315282
3Abnormality of glycolysis (HP:0004366)4.44158845
4Increased serum pyruvate (HP:0003542)4.44158845
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.22042178
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.22042178
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.21725832
8Abnormal mitochondria in muscle tissue (HP:0008316)3.82204651
9Parakeratosis (HP:0001036)3.72939213
10Mitochondrial inheritance (HP:0001427)3.67585053
113-Methylglutaconic aciduria (HP:0003535)3.61801966
12Progressive macrocephaly (HP:0004481)3.57748388
13Neurofibrillary tangles (HP:0002185)3.57675521
14Acute encephalopathy (HP:0006846)3.56194454
15Leukodystrophy (HP:0002415)3.55112848
16Abnormal number of erythroid precursors (HP:0012131)3.53941217
17CNS hypomyelination (HP:0003429)3.47264795
18Pancreatic cysts (HP:0001737)3.27374109
19Peripheral hypomyelination (HP:0007182)3.27223248
20Reticulocytopenia (HP:0001896)3.13087303
21Pancreatic fibrosis (HP:0100732)3.12150941
22Hepatocellular necrosis (HP:0001404)3.10822615
23Renal Fanconi syndrome (HP:0001994)3.09574397
24Increased hepatocellular lipid droplets (HP:0006565)3.08441370
25Sensory axonal neuropathy (HP:0003390)3.06683754
26Increased CSF lactate (HP:0002490)3.05991721
27Congenital ichthyosiform erythroderma (HP:0007431)2.97856691
28True hermaphroditism (HP:0010459)2.96727204
29Segmental peripheral demyelination/remyelination (HP:0003481)2.95992651
30Hyperglycinemia (HP:0002154)2.95734304
31Abnormality of the corticospinal tract (HP:0002492)2.93013819
32Molar tooth sign on MRI (HP:0002419)2.87055613
33Abnormality of midbrain morphology (HP:0002418)2.87055613
34Split foot (HP:0001839)2.71314237
35Muscle fiber splitting (HP:0003555)2.63346783
36Colon cancer (HP:0003003)2.60963404
37Lipid accumulation in hepatocytes (HP:0006561)2.60598598
38Increased muscle lipid content (HP:0009058)2.55494319
39Nephronophthisis (HP:0000090)2.54200988
40Pheochromocytoma (HP:0002666)2.52856154
41Hepatic necrosis (HP:0002605)2.51815640
42Carpal bone hypoplasia (HP:0001498)2.51068748
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.50426798
44Stenosis of the external auditory canal (HP:0000402)2.48740777
45Respiratory failure (HP:0002878)2.45485264
46Neuroendocrine neoplasm (HP:0100634)2.43773961
47Congenital, generalized hypertrichosis (HP:0004540)2.43571479
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43496840
49Lethargy (HP:0001254)2.40724525
50Sclerocornea (HP:0000647)2.37999777
51Hypoplastic pelvis (HP:0008839)2.37605846
52Postnatal microcephaly (HP:0005484)2.36960042
53Spastic paraparesis (HP:0002313)2.34942483
54Abnormal auditory evoked potentials (HP:0006958)2.34875918
55Cerebral inclusion bodies (HP:0100314)2.32065152
56Breast hypoplasia (HP:0003187)2.31290031
57Abnormality of the labia minora (HP:0012880)2.30341552
58Type I transferrin isoform profile (HP:0003642)2.30035652
59Glycosuria (HP:0003076)2.26269949
60Abnormality of urine glucose concentration (HP:0011016)2.26269949
61Retinal dysplasia (HP:0007973)2.23612385
62Onion bulb formation (HP:0003383)2.23022314
63Type 2 muscle fiber atrophy (HP:0003554)2.22925609
64Gait imbalance (HP:0002141)2.22372908
65Autoamputation (HP:0001218)2.22348231
66Congenital primary aphakia (HP:0007707)2.21984335
67Prolonged neonatal jaundice (HP:0006579)2.21559564
68Optic disc pallor (HP:0000543)2.21129132
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20279459
70Abnormality of alanine metabolism (HP:0010916)2.20279459
71Hyperalaninemia (HP:0003348)2.20279459
72Septo-optic dysplasia (HP:0100842)2.19336285
73Abnormality of the umbilical cord (HP:0010881)2.18762198
74Myokymia (HP:0002411)2.18496859
75Morphological abnormality of the inner ear (HP:0011390)2.18149575
76Absent septum pellucidum (HP:0001331)2.17269603
77Respiratory difficulties (HP:0002880)2.16938873
78Alacrima (HP:0000522)2.16866614
79Cerebral edema (HP:0002181)2.13956576
80CNS demyelination (HP:0007305)2.13717860
81Delusions (HP:0000746)2.13405403
82Increased serum lactate (HP:0002151)2.12865730
83Abnormality of the septum pellucidum (HP:0007375)2.10694900
84Nephrogenic diabetes insipidus (HP:0009806)2.08987535
85Adrenal hypoplasia (HP:0000835)2.08718269
86Cerebral hemorrhage (HP:0001342)2.06915341
87Insidious onset (HP:0003587)2.06581452
88Termporal pattern (HP:0011008)2.06581452
89Abnormality of serum amino acid levels (HP:0003112)2.06502090
90Hepatosplenomegaly (HP:0001433)2.06296445
91Spastic gait (HP:0002064)2.05953491
92Pendular nystagmus (HP:0012043)2.05938834
93Poor suck (HP:0002033)2.05184402
94Abnormal glycosylation (HP:0012345)2.04792398
95Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04792398
96Abnormal protein N-linked glycosylation (HP:0012347)2.04792398
97Abnormal protein glycosylation (HP:0012346)2.04792398
98Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.98050563
99Anteriorly placed anus (HP:0001545)1.97606999
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97405113
101Pallor (HP:0000980)1.96586793
102Vaginal atresia (HP:0000148)1.96535057
103Abnormality of the renal medulla (HP:0100957)1.95992662
104Generalized aminoaciduria (HP:0002909)1.95917542
105Hyperphosphaturia (HP:0003109)1.95868105
106Aplasia/Hypoplasia of the tongue (HP:0010295)1.94549267
107Ankle clonus (HP:0011448)1.94464926
108Exercise intolerance (HP:0003546)1.94261498
109External ophthalmoplegia (HP:0000544)1.93908357
110Birth length less than 3rd percentile (HP:0003561)1.92703061
111Genital tract atresia (HP:0001827)1.90423284
112Abnormality of the fetal cardiovascular system (HP:0010948)1.88923435
113Abnormal umbilical cord blood vessels (HP:0011403)1.88923435
114Single umbilical artery (HP:0001195)1.88923435
115Abnormality of renal resorption (HP:0011038)1.87263182
116Muscle fiber atrophy (HP:0100295)1.86712431
117Male pseudohermaphroditism (HP:0000037)1.86298615
118Anencephaly (HP:0002323)1.85618597
119Lactic acidosis (HP:0003128)1.85403433
120Abnormality of placental membranes (HP:0011409)1.83056654
121Amniotic constriction ring (HP:0009775)1.83056654
122Hyperglycinuria (HP:0003108)1.83029714
123Decreased lacrimation (HP:0000633)1.82726502
124Abnormality of the anterior horn cell (HP:0006802)1.82368357
125Degeneration of anterior horn cells (HP:0002398)1.82368357
126Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81755581
127Aplasia/hypoplasia of the uterus (HP:0008684)1.81189888
128Medial flaring of the eyebrow (HP:0010747)1.79039034
129Abnormal autonomic nervous system physiology (HP:0012332)1.78625202
130Abnormality of glycine metabolism (HP:0010895)1.78394048
131Abnormality of serine family amino acid metabolism (HP:0010894)1.78394048
132Abnormal rod and cone electroretinograms (HP:0008323)1.77102167
133Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75844413
134X-linked dominant inheritance (HP:0001423)1.75765799
135Poor speech (HP:0002465)1.75054848
136Macrocytic anemia (HP:0001972)1.74985163
137Emotional lability (HP:0000712)1.74964125
138Hypomagnesemia (HP:0002917)1.74833921
139Methylmalonic acidemia (HP:0002912)1.74280510
140Abolished electroretinogram (ERG) (HP:0000550)1.73849004
141Renal cortical cysts (HP:0000803)1.73127911
142Supranuclear gaze palsy (HP:0000605)1.72678627
143Blindness (HP:0000618)1.72498907
144Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72495198
145Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72495198
146Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72157096
147Type II lissencephaly (HP:0007260)1.72060691
148Abnormality of cells of the erythroid lineage (HP:0012130)1.71479571
149Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71372549
150Optic nerve hypoplasia (HP:0000609)1.70961255
151Limb dystonia (HP:0002451)1.70515883
152Hypoplasia of the uterus (HP:0000013)1.69941051
153Rough bone trabeculation (HP:0100670)1.69926966
154Septate vagina (HP:0001153)1.69536846
155Absent thumb (HP:0009777)1.69163716
156Postaxial foot polydactyly (HP:0001830)1.68781856
157Polyphagia (HP:0002591)1.67793299
158Exertional dyspnea (HP:0002875)1.67694177
159Increased intramyocellular lipid droplets (HP:0012240)1.66803151
160Methylmalonic aciduria (HP:0012120)1.65002970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.80840791
2VRK23.94241223
3BUB13.81599069
4OXSR13.41180850
5PBK2.65766590
6STK162.58254467
7BCR2.55694458
8PNCK2.55002539
9LIMK12.39524897
10MAPKAPK52.36344942
11MAP3K122.29684689
12TESK22.27574451
13NUAK12.15014074
14TRIM282.09964229
15NEK12.03863731
16MST42.03698299
17CSNK1G31.95439880
18PKN11.93122464
19BCKDK1.88548495
20MAP4K21.87517832
21NME21.85841658
22DYRK21.71808396
23WNK41.71527595
24WEE11.69674858
25CDK191.69572507
26ARAF1.67020205
27CSNK1A1L1.63048390
28NME11.62961327
29EPHB11.53647778
30CAMK2B1.51847232
31EIF2AK31.49691691
32MET1.46838834
33CSNK1G11.46119699
34TAF11.45611874
35UHMK11.36441708
36VRK11.34847213
37TSSK61.30026401
38CASK1.28566131
39BMPR1B1.25441685
40CAMK2D1.24970766
41EIF2AK11.21508985
42NEK61.20821191
43CSNK1G21.19791551
44MKNK11.17038488
45CDC71.15980222
46FGFR21.14343247
47SRPK11.10032566
48PASK1.09050443
49MAP2K71.06709268
50MAP3K41.01370147
51AKT31.00647616
52CAMK2G1.00250319
53MARK11.00050298
54INSRR0.98992897
55TESK10.98834239
56DYRK30.98741023
57RPS6KA50.98670059
58EPHA20.95879120
59EPHB20.95595008
60PLK40.95234960
61BRAF0.94914654
62ROCK20.91714371
63MYLK0.91429023
64NTRK10.90772599
65MUSK0.89540713
66CDK140.87105862
67GRK50.85848399
68FRK0.84476518
69PLK30.84074296
70TIE10.83519643
71CLK10.80863900
72PAK10.77679057
73OBSCN0.77202687
74ILK0.76428276
75TGFBR10.75972696
76WNK10.75916120
77SGK2230.75704398
78SGK4940.75704398
79PRKCG0.75592775
80ACVR1B0.74456329
81STK38L0.70486169
82ADRBK20.69713413
83CDK150.69099995
84TLK10.68713693
85CDK180.67973563
86MAPK130.66916073
87ERBB30.66384016
88CCNB10.66151923
89AURKA0.65512609
90CDK11A0.64982480
91GRK70.64793141
92CAMK2A0.63333009
93PDK20.62245525
94MAP2K20.62077680
95FGR0.61796343
96AURKB0.61566235
97BRSK20.59260237
98MAPK150.59139004
99ADRBK10.59064592
100MKNK20.58357555
101PRKCE0.54027187
102WNK30.53561592
103MINK10.53425253
104CSNK1A10.52141760
105PLK20.51087983
106CDK80.50051634
107PINK10.49939903
108ABL20.46032181
109KDR0.45057389
110BRSK10.43875376
111TNIK0.42295683
112DAPK30.42226503
113RPS6KA40.41174031
114PIM20.40962026
115ATR0.40506720
116TTK0.38276658
117PHKG20.38105145
118PHKG10.38105145
119FLT30.37952972
120PRKACB0.37429561
121CSNK1E0.37372059
122NEK20.36434834
123CDK50.36144864
124* CSNK2A20.35470176
125PLK10.34831504
126PRKCI0.33841781
127EIF2AK20.33807680
128IRAK20.33591623
129ZAK0.33051229
130GRK10.33004452
131* CSNK2A10.32336166
132PRKACA0.31792276
133PAK30.31483507
134CDK30.29129783
135CHEK20.29085715
136PRKG10.28920833

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.58430762
2Oxidative phosphorylation_Homo sapiens_hsa001903.93572294
3Proteasome_Homo sapiens_hsa030503.80677037
4Vitamin B6 metabolism_Homo sapiens_hsa007503.54541046
5RNA polymerase_Homo sapiens_hsa030203.52618557
6Parkinsons disease_Homo sapiens_hsa050123.29762127
7Protein export_Homo sapiens_hsa030603.27000979
8Fatty acid elongation_Homo sapiens_hsa000623.13491222
9Steroid biosynthesis_Homo sapiens_hsa001003.02691082
10Ribosome_Homo sapiens_hsa030102.87827764
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.57780663
12Alzheimers disease_Homo sapiens_hsa050102.37002537
13Huntingtons disease_Homo sapiens_hsa050162.34389975
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32999936
15Ether lipid metabolism_Homo sapiens_hsa005652.13508423
16Basal transcription factors_Homo sapiens_hsa030221.79699314
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79006219
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72547296
19Regulation of autophagy_Homo sapiens_hsa041401.58771271
20Folate biosynthesis_Homo sapiens_hsa007901.49258813
21Collecting duct acid secretion_Homo sapiens_hsa049661.49018426
22Pyrimidine metabolism_Homo sapiens_hsa002401.47206984
23Linoleic acid metabolism_Homo sapiens_hsa005911.41481625
24Cardiac muscle contraction_Homo sapiens_hsa042601.41167383
25Spliceosome_Homo sapiens_hsa030401.34987349
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34306754
27One carbon pool by folate_Homo sapiens_hsa006701.32928791
28Sphingolipid metabolism_Homo sapiens_hsa006001.29064828
29Sulfur metabolism_Homo sapiens_hsa009201.27345588
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27298792
31Nucleotide excision repair_Homo sapiens_hsa034201.18466279
32Purine metabolism_Homo sapiens_hsa002301.13789299
33RNA transport_Homo sapiens_hsa030131.11347920
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09297423
35Vibrio cholerae infection_Homo sapiens_hsa051101.07906749
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04824269
37Glutathione metabolism_Homo sapiens_hsa004801.04109789
38Arachidonic acid metabolism_Homo sapiens_hsa005901.03428177
39Mismatch repair_Homo sapiens_hsa034301.02071583
40Selenocompound metabolism_Homo sapiens_hsa004500.99859509
41Homologous recombination_Homo sapiens_hsa034400.99460682
42Peroxisome_Homo sapiens_hsa041460.95366800
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88145511
44Arginine and proline metabolism_Homo sapiens_hsa003300.86249650
45DNA replication_Homo sapiens_hsa030300.85716606
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83877905
47Histidine metabolism_Homo sapiens_hsa003400.83666524
48Metabolic pathways_Homo sapiens_hsa011000.81201758
49Nitrogen metabolism_Homo sapiens_hsa009100.80897616
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.77016082
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74217867
52Non-homologous end-joining_Homo sapiens_hsa034500.70984953
53Rheumatoid arthritis_Homo sapiens_hsa053230.70711278
54Butanoate metabolism_Homo sapiens_hsa006500.68937743
55Chemical carcinogenesis_Homo sapiens_hsa052040.67146103
56Tryptophan metabolism_Homo sapiens_hsa003800.66975898
57Phototransduction_Homo sapiens_hsa047440.63964224
58Serotonergic synapse_Homo sapiens_hsa047260.61747986
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.61249967
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60528117
61RNA degradation_Homo sapiens_hsa030180.59647496
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58385955
63Fat digestion and absorption_Homo sapiens_hsa049750.57135007
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56421777
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55224145
66Carbon metabolism_Homo sapiens_hsa012000.52763132
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52630237
68Retinol metabolism_Homo sapiens_hsa008300.51642526
69Tight junction_Homo sapiens_hsa045300.50211231
70Axon guidance_Homo sapiens_hsa043600.50065089
71Nicotine addiction_Homo sapiens_hsa050330.48562984
72Fanconi anemia pathway_Homo sapiens_hsa034600.48381288
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.48237270
74Cell cycle_Homo sapiens_hsa041100.47738285
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46890986
76Phagosome_Homo sapiens_hsa041450.46769115
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46500320
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46453465
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45516668
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44177220
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.43947434
82Fatty acid degradation_Homo sapiens_hsa000710.43164125
83Mineral absorption_Homo sapiens_hsa049780.43092980
84Basal cell carcinoma_Homo sapiens_hsa052170.42797704
85Epstein-Barr virus infection_Homo sapiens_hsa051690.42624216
86Hedgehog signaling pathway_Homo sapiens_hsa043400.42605477
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42562148
88p53 signaling pathway_Homo sapiens_hsa041150.42556205
89beta-Alanine metabolism_Homo sapiens_hsa004100.42524619
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41393891
91Autoimmune thyroid disease_Homo sapiens_hsa053200.40642700
92Caffeine metabolism_Homo sapiens_hsa002320.40371258
93Renal cell carcinoma_Homo sapiens_hsa052110.39696184
94Oocyte meiosis_Homo sapiens_hsa041140.38882604
95Vitamin digestion and absorption_Homo sapiens_hsa049770.38754842
96GABAergic synapse_Homo sapiens_hsa047270.38610449
97Lysosome_Homo sapiens_hsa041420.38353962
98Base excision repair_Homo sapiens_hsa034100.37973793
99Synaptic vesicle cycle_Homo sapiens_hsa047210.37910749
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37812236
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36699425
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34449968
103Biosynthesis of amino acids_Homo sapiens_hsa012300.33465443
104N-Glycan biosynthesis_Homo sapiens_hsa005100.32268987
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.32138864
106Fatty acid metabolism_Homo sapiens_hsa012120.30372046
107* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28998382
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27962779
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.27180972
110Alcoholism_Homo sapiens_hsa050340.26601717
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26326822
112Olfactory transduction_Homo sapiens_hsa047400.24666988
113Pyruvate metabolism_Homo sapiens_hsa006200.24007742
114Glutamatergic synapse_Homo sapiens_hsa047240.23073742
115Propanoate metabolism_Homo sapiens_hsa006400.22654121
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21577103
117Cocaine addiction_Homo sapiens_hsa050300.21483192
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21398909
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21276852
120Long-term depression_Homo sapiens_hsa047300.20865861
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.20694912
122Tyrosine metabolism_Homo sapiens_hsa003500.19336250
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18749874
124Endocytosis_Homo sapiens_hsa041440.18562301
125mRNA surveillance pathway_Homo sapiens_hsa030150.17786065
126Taste transduction_Homo sapiens_hsa047420.16953946
127Asthma_Homo sapiens_hsa053100.15744988
128Pentose phosphate pathway_Homo sapiens_hsa000300.15272378
129Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.14583358
130Sulfur relay system_Homo sapiens_hsa041220.13605983
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11492987
132Ras signaling pathway_Homo sapiens_hsa040140.09979172

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