RNF7P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)8.33522751
2cytidine metabolic process (GO:0046087)8.33522751
3cytidine catabolic process (GO:0006216)8.33522751
4DNA deamination (GO:0045006)7.50662868
5pyrimidine ribonucleoside catabolic process (GO:0046133)7.25853592
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.12103068
7eosinophil chemotaxis (GO:0048245)6.44788670
8negative regulation by host of viral transcription (GO:0043922)6.02925204
9eosinophil migration (GO:0072677)5.84939934
10sequestering of actin monomers (GO:0042989)5.52421064
11positive thymic T cell selection (GO:0045059)5.37567403
12regulation of regulatory T cell differentiation (GO:0045589)5.22371399
13regulation of activation of Janus kinase activity (GO:0010533)5.15679481
14positive regulation of interleukin-8 secretion (GO:2000484)5.05030115
15regulation of chronic inflammatory response (GO:0002676)4.99786538
16protein neddylation (GO:0045116)4.99656216
17positive T cell selection (GO:0043368)4.93594375
18cell wall macromolecule metabolic process (GO:0044036)4.77197300
19positive regulation of monocyte chemotaxis (GO:0090026)4.60730248
20dendritic cell chemotaxis (GO:0002407)4.51125268
21monocyte chemotaxis (GO:0002548)4.48590491
22negative regulation of T cell apoptotic process (GO:0070233)4.44268012
23macrophage chemotaxis (GO:0048246)4.40499294
24positive regulation of T cell chemotaxis (GO:0010820)4.34101966
25regulation of T cell chemotaxis (GO:0010819)4.34101966
26positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.31643356
27positive regulation of natural killer cell mediated immunity (GO:0002717)4.30449106
28regulation of interleukin-8 secretion (GO:2000482)4.29372941
29regulation of lymphocyte chemotaxis (GO:1901623)4.23063726
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.07275095
31negative regulation of viral genome replication (GO:0045071)4.04730035
32regulation of chemokine-mediated signaling pathway (GO:0070099)3.97038433
33platelet dense granule organization (GO:0060155)3.96799860
34positive regulation of T cell apoptotic process (GO:0070234)3.94281967
35production of molecular mediator involved in inflammatory response (GO:0002532)3.92035871
36positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.86418473
37dendritic cell migration (GO:0036336)3.85804552
38pyrimidine nucleoside catabolic process (GO:0046135)3.82886913
39positive regulation of tolerance induction (GO:0002645)3.80333213
40regulation of natural killer cell mediated immunity (GO:0002715)3.77435316
41regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.77435316
42cytolysis (GO:0019835)3.74016923
43regulation of mononuclear cell migration (GO:0071675)3.73245106
44Arp2/3 complex-mediated actin nucleation (GO:0034314)3.72468514
45response to interleukin-15 (GO:0070672)3.71733423
46regulation of interleukin-2 biosynthetic process (GO:0045076)3.68705739
47antigen processing and presentation via MHC class Ib (GO:0002475)3.67367427
48positive regulation of translational initiation (GO:0045948)3.63905764
49cellular response to interleukin-15 (GO:0071350)3.63558703
50actin nucleation (GO:0045010)3.50881790
51positive regulation of cell killing (GO:0031343)3.49605508
52positive regulation of chemokine secretion (GO:0090197)3.49147677
53negative regulation of mast cell activation (GO:0033004)3.47392175
54regulation of leukocyte mediated cytotoxicity (GO:0001910)3.46746567
55positive regulation of calcium-mediated signaling (GO:0050850)3.46678870
56cellular defense response (GO:0006968)3.40769253
57regulation of interleukin-12 biosynthetic process (GO:0045075)3.38558846
58modulation by host of viral transcription (GO:0043921)3.34761336
59modulation by host of symbiont transcription (GO:0052472)3.34761336
60regulation of T cell tolerance induction (GO:0002664)3.33938993
61negative regulation of lymphocyte apoptotic process (GO:0070229)3.30164592
62positive regulation of lymphocyte migration (GO:2000403)3.28121400
63positive regulation of lymphocyte apoptotic process (GO:0070230)3.25178173
64negative T cell selection (GO:0043383)3.24116995
65DNA demethylation (GO:0080111)3.22011772
66positive regulation of T cell mediated cytotoxicity (GO:0001916)3.21863751
67regulation of cell killing (GO:0031341)3.20264779
68thymic T cell selection (GO:0045061)3.19850809
69modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.18755947
70negative regulation of viral transcription (GO:0032897)3.17481811
71negative regulation of calcium ion transport into cytosol (GO:0010523)3.16576218
72regulation of cellular amino acid metabolic process (GO:0006521)3.16383968
73regulation of macrophage chemotaxis (GO:0010758)3.15675734
74mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.12207763
75T cell costimulation (GO:0031295)3.10768140
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.09622778
77lymphocyte costimulation (GO:0031294)3.06917423
78regulation of tolerance induction (GO:0002643)3.06719560
79regulation of chemokine secretion (GO:0090196)3.06617803
80T cell selection (GO:0045058)3.00584398
81antigen processing and presentation of endogenous antigen (GO:0019883)2.99528332
82terpenoid biosynthetic process (GO:0016114)2.98815289
83DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.92638673
84signal peptide processing (GO:0006465)2.92250272
85mitochondrial DNA replication (GO:0006264)2.91969644
86negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91325223
87negative regulation of B cell proliferation (GO:0030889)2.90530287
88regulation of monocyte chemotaxis (GO:0090025)2.89815215
89antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.89307156
90positive regulation of leukocyte apoptotic process (GO:2000108)2.88766072
91regulation of T cell mediated cytotoxicity (GO:0001914)2.88100454
92response to pheromone (GO:0019236)2.86574523
93regulation of viral genome replication (GO:0045069)2.86423157
94positive regulation of defense response to virus by host (GO:0002230)2.86393292
95signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86222526
96signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86222526
97signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86222526
98regulation of homotypic cell-cell adhesion (GO:0034110)2.84485481
99diterpenoid biosynthetic process (GO:0016102)2.84157726
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.82353509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.33163354
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.26775326
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.03671471
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.95112883
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88481025
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.86125802
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.70562258
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34864234
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34814584
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.31529237
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27701587
12VDR_22108803_ChIP-Seq_LS180_Human2.11625626
13BP1_19119308_ChIP-ChIP_Hs578T_Human10.2636814
14MYB_26560356_Chip-Seq_TH2_Human1.99742684
15STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92527424
16LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.90517313
17STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83178881
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.82411975
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.79050557
20GATA3_26560356_Chip-Seq_TH2_Human1.69020491
21ZNF274_21170338_ChIP-Seq_K562_Hela1.68829313
22VDR_23849224_ChIP-Seq_CD4+_Human1.67798368
23GATA3_27048872_Chip-Seq_THYMUS_Human1.67206857
24RUNX_20019798_ChIP-Seq_JUKART_Human1.63178705
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54853530
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52270122
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46244663
28PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.43187190
29TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.40134590
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.36825343
31CIITA_25753668_ChIP-Seq_RAJI_Human1.36287224
32TP53_22573176_ChIP-Seq_HFKS_Human1.32094965
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.26994280
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25097267
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24411480
36BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.24303333
37IGF1R_20145208_ChIP-Seq_DFB_Human1.21667539
38HTT_18923047_ChIP-ChIP_STHdh_Human1.19168418
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18740412
40TAF2_19829295_ChIP-Seq_ESCs_Human1.18335222
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17470841
42EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15611165
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15141138
44GATA3_21878914_ChIP-Seq_MCF-7_Human1.14823993
45AR_20517297_ChIP-Seq_VCAP_Human1.14276185
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13876360
47FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11983816
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10521885
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10159976
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.10159976
51FOXH1_21741376_ChIP-Seq_EPCs_Human1.09470327
52NANOG_19829295_ChIP-Seq_ESCs_Human1.09192994
53SOX2_19829295_ChIP-Seq_ESCs_Human1.09192994
54NANOG_20526341_ChIP-Seq_ESCs_Human1.08683109
55GATA3_26560356_Chip-Seq_TH1_Human1.08467786
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07297809
57GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07137725
58ER_23166858_ChIP-Seq_MCF-7_Human1.06935811
59PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06079701
60MYB_26560356_Chip-Seq_TH1_Human1.03859127
61ERG_20517297_ChIP-Seq_VCAP_Human1.03139926
62CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02381787
63FOXP3_21729870_ChIP-Seq_TREG_Human1.02341764
64GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01166671
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.00923604
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00775678
67P300_27268052_Chip-Seq_Bcells_Human1.00205035
68MAF_26560356_Chip-Seq_TH2_Human0.99889821
69YY1_22570637_ChIP-Seq_MALME-3M_Human0.99836804
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99701154
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99176645
72MYC_18940864_ChIP-ChIP_HL60_Human0.98570100
73PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98134770
74ELF1_20517297_ChIP-Seq_JURKAT_Human0.95712893
75NCOR_22424771_ChIP-Seq_293T_Human0.95420126
76POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95295955
77STAT1_20625510_ChIP-Seq_HELA_Human0.95223604
78EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94875855
79ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94421400
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93356991
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92844140
82BCAT_22108803_ChIP-Seq_LS180_Human0.92536220
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92248697
84GATA6_21074721_ChIP-Seq_CACO-2_Human0.91826116
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91234944
86EZH2_22144423_ChIP-Seq_EOC_Human0.91139648
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89442392
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.89360583
89BCL6_27268052_Chip-Seq_Bcells_Human0.88862838
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88361049
91OCT4_20526341_ChIP-Seq_ESCs_Human0.88347350
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87985749
93UTX_26944678_Chip-Seq_JUKART_Human0.87036664
94TAF15_26573619_Chip-Seq_HEK293_Human0.86762302
95RBPJ_21746931_ChIP-Seq_IB4_Human0.86308848
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85260595
97ETS1_20019798_ChIP-Seq_JURKAT_Human0.83527222
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83056167
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82736449
100CBP_20019798_ChIP-Seq_JUKART_Human0.82736449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.41454160
2MP0001835_abnormal_antigen_presentation3.85256270
3MP0006082_CNS_inflammation2.96281389
4MP0009785_altered_susceptibility_to2.90889319
5MP0003866_abnormal_defecation2.73171322
6MP0002148_abnormal_hypersensitivity_rea2.62209839
7MP0003763_abnormal_thymus_physiology2.59941424
8MP0005387_immune_system_phenotype2.51216874
9MP0001790_abnormal_immune_system2.51216874
10MP0000569_abnormal_digit_pigmentation2.48863257
11MP0001800_abnormal_humoral_immune2.47348811
12MP0001873_stomach_inflammation2.40665445
13MP0005000_abnormal_immune_tolerance2.35112754
14MP0005645_abnormal_hypothalamus_physiol2.28400985
15MP0010155_abnormal_intestine_physiology2.22870240
16MP0002723_abnormal_immune_serum2.21275815
17MP0005025_abnormal_response_to2.11667816
18MP0009333_abnormal_splenocyte_physiolog2.11371945
19MP0002166_altered_tumor_susceptibility2.08968742
20MP0002420_abnormal_adaptive_immunity2.03256442
21MP0001819_abnormal_immune_cell1.99102127
22MP0003011_delayed_dark_adaptation1.85801042
23MP0003646_muscle_fatigue1.80254145
24MP0000685_abnormal_immune_system1.78150900
25MP0002452_abnormal_antigen_presenting1.71976267
26MP0002006_tumorigenesis1.70100862
27MP0002909_abnormal_adrenal_gland1.68029159
28MP0000716_abnormal_immune_system1.63327989
29MP0001845_abnormal_inflammatory_respons1.58682965
30MP0002405_respiratory_system_inflammati1.57277529
31MP0002398_abnormal_bone_marrow1.56469613
32MP0001188_hyperpigmentation1.50815341
33MP0005174_abnormal_tail_pigmentation1.50705193
34MP0006072_abnormal_retinal_apoptosis1.49562640
35MP0005377_hearing/vestibular/ear_phenot1.45704593
36MP0003878_abnormal_ear_physiology1.45704593
37MP0002876_abnormal_thyroid_physiology1.44682170
38MP0005083_abnormal_biliary_tract1.44161546
39MP0003786_premature_aging1.44016104
40MP0008872_abnormal_physiological_respon1.42287788
41MP0005075_abnormal_melanosome_morpholog1.37302289
42MP0005253_abnormal_eye_physiology1.34285722
43MP0002095_abnormal_skin_pigmentation1.34212907
44MP0002138_abnormal_hepatobiliary_system1.34212668
45MP0000689_abnormal_spleen_morphology1.32563893
46MP0001661_extended_life_span1.32005820
47MP0001919_abnormal_reproductive_system1.31890211
48MP0002429_abnormal_blood_cell1.26586349
49MP0002722_abnormal_immune_system1.25112376
50MP0005670_abnormal_white_adipose1.20057195
51MP0003806_abnormal_nucleotide_metabolis1.19423329
52MP0005084_abnormal_gallbladder_morpholo1.17919061
53MP0002933_joint_inflammation1.16771795
54MP0001764_abnormal_homeostasis1.16299257
55MP0002277_abnormal_respiratory_mucosa1.15437178
56MP0002693_abnormal_pancreas_physiology1.12994313
57MP0001905_abnormal_dopamine_level1.10784494
58MP0002733_abnormal_thermal_nociception1.07982419
59MP0008875_abnormal_xenobiotic_pharmacok1.04799600
60MP0001968_abnormal_touch/_nociception1.02170757
61MP0005551_abnormal_eye_electrophysiolog1.01991187
62MP0002234_abnormal_pharynx_morphology1.01922178
63MP0005389_reproductive_system_phenotype1.01883830
64MP0002419_abnormal_innate_immunity1.00890475
65MP0004147_increased_porphyrin_level1.00075624
66MP0003195_calcinosis0.99930744
67MP0000703_abnormal_thymus_morphology0.99238293
68MP0008469_abnormal_protein_level0.99042945
69MP0002736_abnormal_nociception_after0.98305518
70MP0009763_increased_sensitivity_to0.96122265
71MP0004145_abnormal_muscle_electrophysio0.92250766
72MP0005636_abnormal_mineral_homeostasis0.91505666
73MP0004043_abnormal_pH_regulation0.89888152
74MP0005464_abnormal_platelet_physiology0.89826596
75MP0005310_abnormal_salivary_gland0.89804444
76MP0001970_abnormal_pain_threshold0.89114070
77MP0001853_heart_inflammation0.87450227
78MP0003075_altered_response_to0.84959446
79MP0009745_abnormal_behavioral_response0.84003931
80MP0002102_abnormal_ear_morphology0.83597160
81MP0000372_irregular_coat_pigmentation0.80587538
82MP0000015_abnormal_ear_pigmentation0.80307214
83MP0000427_abnormal_hair_cycle0.80013006
84MP0000465_gastrointestinal_hemorrhage0.79206084
85MP0002877_abnormal_melanocyte_morpholog0.79092768
86MP0004130_abnormal_muscle_cell0.79038932
87MP0005167_abnormal_blood-brain_barrier0.77916230
88MP0001485_abnormal_pinna_reflex0.76165638
89MP0009765_abnormal_xenobiotic_induced0.75433196
90MP0000343_altered_response_to0.71643912
91MP0002163_abnormal_gland_morphology0.71555612
92MP0003436_decreased_susceptibility_to0.71493846
93MP0003137_abnormal_impulse_conducting0.70353466
94MP0002638_abnormal_pupillary_reflex0.69342058
95MP0003448_altered_tumor_morphology0.69298003
96MP0010329_abnormal_lipoprotein_level0.68931969
97MP0010307_abnormal_tumor_latency0.68930526
98MP0002837_dystrophic_cardiac_calcinosis0.66790567
99MP0000920_abnormal_myelination0.65557775
100MP0003724_increased_susceptibility_to0.62505469

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.24709543
2Abnormality of T cell number (HP:0011839)5.02325506
3Hypoproteinemia (HP:0003075)4.15019114
4IgG deficiency (HP:0004315)4.02899370
5Abnormality of T cells (HP:0002843)3.92308177
6Abnormal delayed hypersensitivity skin test (HP:0002963)3.91253941
7Congenital stationary night blindness (HP:0007642)3.78383853
8Abnormal albumin level (HP:0012116)3.61262101
9Hypoalbuminemia (HP:0003073)3.61262101
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.57551238
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.57551238
12Mitochondrial inheritance (HP:0001427)3.55223517
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.53711524
14Abnormality of midbrain morphology (HP:0002418)3.53499324
15Molar tooth sign on MRI (HP:0002419)3.53499324
16Abnormality of the prostate (HP:0008775)3.43258475
17Aplastic anemia (HP:0001915)3.34941712
18Pancreatic cysts (HP:0001737)3.31303262
19Recurrent bronchitis (HP:0002837)3.25198576
20Agammaglobulinemia (HP:0004432)3.10952796
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.10373912
22Acute necrotizing encephalopathy (HP:0006965)3.05678997
23Chronic mucocutaneous candidiasis (HP:0002728)3.03824284
24Recurrent cutaneous fungal infections (HP:0011370)3.03824284
253-Methylglutaconic aciduria (HP:0003535)3.01829085
26Chronic diarrhea (HP:0002028)3.00471031
27Pustule (HP:0200039)2.98775252
28Meningitis (HP:0001287)2.95861700
29True hermaphroditism (HP:0010459)2.94290728
30Elevated erythrocyte sedimentation rate (HP:0003565)2.88925869
31Increased CSF lactate (HP:0002490)2.87262918
32Severe visual impairment (HP:0001141)2.77617143
33Progressive macrocephaly (HP:0004481)2.77423408
34Bronchitis (HP:0012387)2.76203003
35Cutaneous melanoma (HP:0012056)2.75269466
36Pancreatic fibrosis (HP:0100732)2.72342690
37Recurrent otitis media (HP:0000403)2.66174212
38Abnormal mitochondria in muscle tissue (HP:0008316)2.65111772
39Hepatocellular necrosis (HP:0001404)2.63925721
40Abnormal rod and cone electroretinograms (HP:0008323)2.59869892
41Increased IgM level (HP:0003496)2.59869126
42Abolished electroretinogram (ERG) (HP:0000550)2.59856690
43Hemoptysis (HP:0002105)2.59305716
44Increased intramyocellular lipid droplets (HP:0012240)2.56423121
45Lymphopenia (HP:0001888)2.51052935
46Myositis (HP:0100614)2.47395704
47Hepatic necrosis (HP:0002605)2.46845016
48Encephalitis (HP:0002383)2.44177508
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.41425623
50Stomatitis (HP:0010280)2.38299101
51Abnormality of T cell physiology (HP:0011840)2.34299332
52Panhypogammaglobulinemia (HP:0003139)2.32715843
53Joint swelling (HP:0001386)2.32692268
54Gangrene (HP:0100758)2.28992321
55Hematochezia (HP:0002573)2.28237885
56Acute encephalopathy (HP:0006846)2.27652422
57Hemiplegia (HP:0002301)2.26924285
58Ureteral stenosis (HP:0000071)2.18353750
59Severe combined immunodeficiency (HP:0004430)2.18150020
60Methylmalonic aciduria (HP:0012120)2.13960146
61Chronic sinusitis (HP:0011109)2.13603969
62Renal cortical cysts (HP:0000803)2.13532128
63Cerebral edema (HP:0002181)2.12240313
64Recurrent skin infections (HP:0001581)2.10621387
65Exercise intolerance (HP:0003546)2.10454143
66Pulmonary infiltrates (HP:0002113)2.09063694
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08536551
68Bile duct proliferation (HP:0001408)2.07941701
69Abnormal biliary tract physiology (HP:0012439)2.07941701
70Recurrent fungal infections (HP:0002841)2.07498528
71Thyroiditis (HP:0100646)2.05869163
72Attenuation of retinal blood vessels (HP:0007843)2.05294530
73Chronic bronchitis (HP:0004469)2.04936716
74Keratoconus (HP:0000563)2.03301298
75Increased corneal curvature (HP:0100692)2.03301298
76Obstructive lung disease (HP:0006536)2.03212949
77Chronic obstructive pulmonary disease (HP:0006510)2.03212949
78Abnormality of eosinophils (HP:0001879)2.02220429
79Bronchiectasis (HP:0002110)2.01020336
80Vasculitis (HP:0002633)2.00758004
81Medial flaring of the eyebrow (HP:0010747)1.98309851
82Increased muscle lipid content (HP:0009058)1.98064425
83Amyotrophic lateral sclerosis (HP:0007354)1.98029269
84Delayed CNS myelination (HP:0002188)1.97500217
85Lactic acidosis (HP:0003128)1.97018035
86Increased hepatocellular lipid droplets (HP:0006565)1.96862144
87Gastrointestinal infarctions (HP:0005244)1.96672883
88Cystic liver disease (HP:0006706)1.96118425
89Increased serum lactate (HP:0002151)1.95606202
90Abnormality of the pleura (HP:0002103)1.94985885
91Microretrognathia (HP:0000308)1.94308152
92Generalized aminoaciduria (HP:0002909)1.93920154
93Hypothermia (HP:0002045)1.93690439
94Cerebral palsy (HP:0100021)1.91412983
95Autoimmune hemolytic anemia (HP:0001890)1.90978758
96Sclerocornea (HP:0000647)1.90734887
97Progressive external ophthalmoplegia (HP:0000590)1.90138210
98Ureteral obstruction (HP:0006000)1.89989603
99Dicarboxylic aciduria (HP:0003215)1.89718062
100Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89718062

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK27.91079189
2TXK6.06691282
3KDR3.72904939
4MAP4K23.68587762
5GRK12.52643123
6MAPKAPK32.27311521
7ADRBK22.20980050
8MAP3K122.20752523
9LIMK12.14700258
10FRK2.00771701
11VRK22.00591725
12GRK71.98458709
13ZAK1.88681709
14BCKDK1.75742119
15ITK1.73489943
16MAP4K11.72437811
17TESK11.68316860
18FES1.52465284
19DAPK21.51802021
20STK161.51353260
21BUB11.47964886
22WNK41.38248162
23TLK11.37398209
24NUAK11.29651851
25SYK1.23388464
26DAPK11.16814127
27ARAF1.11543567
28TAOK31.11294544
29TRIM281.09756137
30PIK3CG1.08518956
31MYLK1.07634539
32MST41.02013371
33LCK1.01927968
34PRKCQ1.01366142
35VRK11.00848947
36EIF2AK30.93113197
37NME10.86276466
38CSK0.85378343
39CSF1R0.82274546
40MAP2K60.81311497
41TRPM70.78886148
42OXSR10.73019033
43SRPK10.70928132
44TAF10.69254567
45ERBB30.68387405
46PIM20.67388086
47PDK20.66788475
48ZAP700.65463045
49BCR0.62998845
50GRK60.61850981
51ADRBK10.61724905
52TBK10.61319893
53CSNK1G30.60495739
54RPS6KA50.56981213
55LYN0.56348793
56INSRR0.55720306
57MELK0.55508138
58JAK30.54454285
59MAPK110.51368299
60RIPK40.50847049
61CLK10.49884835
62IKBKE0.49288746
63PDK10.48388394
64ACVR1B0.46829386
65TIE10.46635614
66CSNK1G20.41802100
67ROCK10.40907110
68PIM10.40564629
69TYK20.40507579
70DAPK30.39972564
71FYN0.39873526
72CSNK1A1L0.38213959
73MAPK150.38187529
74OBSCN0.37744610
75ABL20.37444959
76GRK50.34812478
77DYRK20.34591931
78IRAK40.34571408
79TYRO30.34071221
80FGFR20.33879545
81MUSK0.33104210
82WNK30.32490674
83TEC0.32374311
84IGF1R0.31638744
85NEK20.31476151
86CAMK2A0.31112006
87PRKCA0.30548749
88IKBKB0.29919684
89PIK3CA0.29871042
90CSNK1G10.29393498
91SIK20.28774710
92MAPK130.27387093
93CCNB10.26948119
94PRKCE0.26569911
95MAP3K130.25735947
96MINK10.25445693
97TNK20.24573343
98CAMKK20.22207385
99PRKACA0.21436412
100BMPR1B0.21179226

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.54037450
2Primary immunodeficiency_Homo sapiens_hsa053404.28502665
3Antigen processing and presentation_Homo sapiens_hsa046123.90787474
4Autoimmune thyroid disease_Homo sapiens_hsa053203.77398096
5Graft-versus-host disease_Homo sapiens_hsa053323.43610677
6Allograft rejection_Homo sapiens_hsa053303.41512765
7Rheumatoid arthritis_Homo sapiens_hsa053232.96819515
8Type I diabetes mellitus_Homo sapiens_hsa049402.82442825
9Oxidative phosphorylation_Homo sapiens_hsa001902.75316851
10Hematopoietic cell lineage_Homo sapiens_hsa046402.40314500
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.35600702
12Parkinsons disease_Homo sapiens_hsa050122.34441506
13Phototransduction_Homo sapiens_hsa047442.28318806
14Asthma_Homo sapiens_hsa053102.25725103
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.06780089
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.99945924
17Protein export_Homo sapiens_hsa030601.85579919
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.71106823
19Alzheimers disease_Homo sapiens_hsa050101.59165957
20RNA polymerase_Homo sapiens_hsa030201.54002344
21T cell receptor signaling pathway_Homo sapiens_hsa046601.52079976
22Linoleic acid metabolism_Homo sapiens_hsa005911.47420212
23Viral myocarditis_Homo sapiens_hsa054161.36860853
24Salmonella infection_Homo sapiens_hsa051321.35518419
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34844496
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33372346
27Huntingtons disease_Homo sapiens_hsa050161.30474531
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26232129
29Caffeine metabolism_Homo sapiens_hsa002321.26179242
30Cardiac muscle contraction_Homo sapiens_hsa042601.19624582
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16632556
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99502368
33Peroxisome_Homo sapiens_hsa041460.95500220
34NF-kappa B signaling pathway_Homo sapiens_hsa040640.95213982
35NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94823574
36Staphylococcus aureus infection_Homo sapiens_hsa051500.94677760
37Measles_Homo sapiens_hsa051620.92600975
38Collecting duct acid secretion_Homo sapiens_hsa049660.84332380
39Systemic lupus erythematosus_Homo sapiens_hsa053220.81568275
40Nitrogen metabolism_Homo sapiens_hsa009100.78516591
41Retinol metabolism_Homo sapiens_hsa008300.76407922
42Olfactory transduction_Homo sapiens_hsa047400.75083452
43Shigellosis_Homo sapiens_hsa051310.71482327
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71331844
45Ether lipid metabolism_Homo sapiens_hsa005650.68716091
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68134660
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67740576
48Salivary secretion_Homo sapiens_hsa049700.67417038
49Chemokine signaling pathway_Homo sapiens_hsa040620.67374491
50Chemical carcinogenesis_Homo sapiens_hsa052040.65216774
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65142908
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65007828
53Purine metabolism_Homo sapiens_hsa002300.64398201
54Pyrimidine metabolism_Homo sapiens_hsa002400.62659250
55Butanoate metabolism_Homo sapiens_hsa006500.62144847
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.59433447
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58558706
58Propanoate metabolism_Homo sapiens_hsa006400.56528905
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52024654
60Prion diseases_Homo sapiens_hsa050200.49688036
61Homologous recombination_Homo sapiens_hsa034400.47516104
62Herpes simplex infection_Homo sapiens_hsa051680.46431168
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.42397461
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41557905
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41547233
66Fanconi anemia pathway_Homo sapiens_hsa034600.40803369
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40447899
68Leishmaniasis_Homo sapiens_hsa051400.39104438
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36499164
70Regulation of autophagy_Homo sapiens_hsa041400.35423051
71Arachidonic acid metabolism_Homo sapiens_hsa005900.35419466
72Sulfur metabolism_Homo sapiens_hsa009200.35405483
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35133668
74Epstein-Barr virus infection_Homo sapiens_hsa051690.34627118
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34166218
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.34134384
77Malaria_Homo sapiens_hsa051440.31390112
78RNA degradation_Homo sapiens_hsa030180.31338259
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31171218
80Tryptophan metabolism_Homo sapiens_hsa003800.30837054
81Nucleotide excision repair_Homo sapiens_hsa034200.30349249
82HTLV-I infection_Homo sapiens_hsa051660.30027365
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29747667
84Ribosome_Homo sapiens_hsa030100.28127628
85Metabolic pathways_Homo sapiens_hsa011000.27405945
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.26259924
87Influenza A_Homo sapiens_hsa051640.24548359
88Pertussis_Homo sapiens_hsa051330.24469211
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.23444016
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.22580061
91Phagosome_Homo sapiens_hsa041450.21708690
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21432958
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21282637
94Morphine addiction_Homo sapiens_hsa050320.16372295
95African trypanosomiasis_Homo sapiens_hsa051430.16301297
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.13961507
97Tuberculosis_Homo sapiens_hsa051520.13843473
98Lysosome_Homo sapiens_hsa041420.13657257
99Endocytosis_Homo sapiens_hsa041440.12281266
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11572489

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