RNF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.24402029
2DNA deamination (GO:0045006)4.82762430
3metaphase plate congression (GO:0051310)4.50982634
4protein localization to kinetochore (GO:0034501)4.42056758
5DNA replication checkpoint (GO:0000076)4.34066990
6purine nucleobase biosynthetic process (GO:0009113)4.33941909
7DNA strand elongation involved in DNA replication (GO:0006271)4.32541553
8DNA replication initiation (GO:0006270)4.32409039
9nucleobase biosynthetic process (GO:0046112)4.32187506
10CENP-A containing nucleosome assembly (GO:0034080)4.31388303
11regulation of mitochondrial translation (GO:0070129)4.22315049
12telomere maintenance via semi-conservative replication (GO:0032201)4.15782021
13chromatin remodeling at centromere (GO:0031055)4.14037534
14DNA strand elongation (GO:0022616)4.13331894
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.07780167
16ribosome assembly (GO:0042255)4.01512034
17kinetochore assembly (GO:0051382)3.99503654
18protein localization to chromosome, centromeric region (GO:0071459)3.99012740
19ribosome biogenesis (GO:0042254)3.97639097
20formation of translation preinitiation complex (GO:0001731)3.94819814
21proteasome assembly (GO:0043248)3.93792130
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.92661337
23rRNA modification (GO:0000154)3.90688983
24protein complex biogenesis (GO:0070271)3.90201314
25kinetochore organization (GO:0051383)3.85394570
26DNA replication-independent nucleosome assembly (GO:0006336)3.83853152
27DNA replication-independent nucleosome organization (GO:0034724)3.83853152
28establishment of chromosome localization (GO:0051303)3.80899307
29chaperone-mediated protein transport (GO:0072321)3.79464513
30maturation of SSU-rRNA (GO:0030490)3.77978322
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.75491726
32regulation of spindle organization (GO:0090224)3.74736232
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.72755788
34pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.72702450
35mitochondrial respiratory chain complex assembly (GO:0033108)3.72377170
36cytochrome complex assembly (GO:0017004)3.69767229
37telomere maintenance via recombination (GO:0000722)3.69033199
38DNA double-strand break processing (GO:0000729)3.61162011
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.60307760
40mitotic chromosome condensation (GO:0007076)3.59738018
41negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.59028560
42spliceosomal snRNP assembly (GO:0000387)3.58469702
43respiratory chain complex IV assembly (GO:0008535)3.57759019
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.52140712
457-methylguanosine mRNA capping (GO:0006370)3.51146501
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.50533451
47mitotic nuclear envelope disassembly (GO:0007077)3.50281165
48telomere maintenance via telomere lengthening (GO:0010833)3.49628907
49* histone exchange (GO:0043486)3.49517534
50termination of RNA polymerase III transcription (GO:0006386)3.46557798
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.46557798
52protein deneddylation (GO:0000338)3.46451508
53negative regulation of chromosome segregation (GO:0051985)3.46097078
54negative regulation of mitotic sister chromatid separation (GO:2000816)3.44260688
55negative regulation of mitotic sister chromatid segregation (GO:0033048)3.44260688
56negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.44260688
57negative regulation of sister chromatid segregation (GO:0033046)3.44260688
58spindle checkpoint (GO:0031577)3.44106816
59mitotic sister chromatid segregation (GO:0000070)3.43542828
60maturation of 5.8S rRNA (GO:0000460)3.41530240
61rRNA methylation (GO:0031167)3.41197789
627-methylguanosine RNA capping (GO:0009452)3.41150284
63RNA capping (GO:0036260)3.41150284
64DNA unwinding involved in DNA replication (GO:0006268)3.41007280
65mitotic recombination (GO:0006312)3.39139642
66deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.37259509
67attachment of spindle microtubules to kinetochore (GO:0008608)3.36734637
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.35486234
69mitotic spindle assembly checkpoint (GO:0007094)3.35163471
70regulation of chromosome segregation (GO:0051983)3.34876352
71energy coupled proton transport, down electrochemical gradient (GO:0015985)3.33129633
72ATP synthesis coupled proton transport (GO:0015986)3.33129633
73spindle assembly checkpoint (GO:0071173)3.29606849
74ribonucleoprotein complex biogenesis (GO:0022613)3.28662410
75mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26393995
76nuclear envelope disassembly (GO:0051081)3.25857831
77membrane disassembly (GO:0030397)3.25857831
78regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.25336002
79mitotic spindle checkpoint (GO:0071174)3.24846171
80mitochondrial respiratory chain complex I assembly (GO:0032981)3.23454996
81NADH dehydrogenase complex assembly (GO:0010257)3.23454996
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23454996
83regulation of double-strand break repair via homologous recombination (GO:0010569)3.23403766
84piRNA metabolic process (GO:0034587)3.23099213
85water-soluble vitamin biosynthetic process (GO:0042364)3.22431741
86establishment of protein localization to mitochondrial membrane (GO:0090151)3.21671249
87protein K6-linked ubiquitination (GO:0085020)3.21403218
88transcription-coupled nucleotide-excision repair (GO:0006283)3.20388226
89rRNA processing (GO:0006364)3.19929750
90protein-cofactor linkage (GO:0018065)3.18366343
91pyrimidine nucleotide catabolic process (GO:0006244)3.17878738
92nucleotide-excision repair, DNA gap filling (GO:0006297)3.15297863
93negative regulation of ligase activity (GO:0051352)3.15241287
94negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15241287
95DNA replication-dependent nucleosome assembly (GO:0006335)3.15031523
96DNA replication-dependent nucleosome organization (GO:0034723)3.15031523
97regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13218971
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13072934
99protein localization to chromosome (GO:0034502)3.12334675
100rRNA metabolic process (GO:0016072)3.10344011
101base-excision repair, AP site formation (GO:0006285)3.10207781
102folic acid-containing compound biosynthetic process (GO:0009396)3.09309403
103pseudouridine synthesis (GO:0001522)3.08606396
104* negative regulation of DNA-templated transcription, elongation (GO:0032785)3.07958973
105* negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.07958973
106pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.06511075
107maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.04162564
108cell cycle G1/S phase transition (GO:0044843)3.04006218
109G1/S transition of mitotic cell cycle (GO:0000082)3.04006218
110regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00878894
111regulation of mitotic spindle checkpoint (GO:1903504)3.00878894
112regulation of mitotic sister chromatid separation (GO:0010965)3.00137439
113regulation of mitotic sister chromatid segregation (GO:0033047)3.00137439
114regulation of sister chromatid segregation (GO:0033045)3.00137439
115cullin deneddylation (GO:0010388)2.99163056
116establishment of integrated proviral latency (GO:0075713)2.98902433
117positive regulation of ligase activity (GO:0051351)2.98856597
118protein neddylation (GO:0045116)2.98017267
119transcription from mitochondrial promoter (GO:0006390)2.96665655
120peptidyl-histidine modification (GO:0018202)2.96418942
121folic acid metabolic process (GO:0046655)2.95726739
122transcription elongation from RNA polymerase I promoter (GO:0006362)2.95664366
123histone H2A acetylation (GO:0043968)2.95219410
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92237399
125kynurenine metabolic process (GO:0070189)2.91249471
126somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90994197
127somatic hypermutation of immunoglobulin genes (GO:0016446)2.90994197
128replication fork processing (GO:0031297)2.88349332
129exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88012948
130resolution of meiotic recombination intermediates (GO:0000712)2.85412721
131respiratory electron transport chain (GO:0022904)2.82827549
132DNA damage response, detection of DNA damage (GO:0042769)2.81636435
133electron transport chain (GO:0022900)2.81030915
134synapsis (GO:0007129)2.73428825
135DNA catabolic process, exonucleolytic (GO:0000738)2.73189530
136RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.72926370
137tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.72926370
138cellular component biogenesis (GO:0044085)2.67620696
139recombinational repair (GO:0000725)2.67536770
140negative regulation of DNA-dependent DNA replication (GO:2000104)2.67489754
141inner mitochondrial membrane organization (GO:0007007)2.67029527
142positive regulation of mitochondrial fission (GO:0090141)2.66010801
143protein targeting to mitochondrion (GO:0006626)2.65936201
144regulation of centriole replication (GO:0046599)2.65142679
145double-strand break repair via homologous recombination (GO:0000724)2.64570895
146ribosomal large subunit biogenesis (GO:0042273)2.63843896
147mitochondrial RNA metabolic process (GO:0000959)2.63248943
148indole-containing compound catabolic process (GO:0042436)2.62925201
149indolalkylamine catabolic process (GO:0046218)2.62925201
150tryptophan catabolic process (GO:0006569)2.62925201
151microtubule depolymerization (GO:0007019)2.61711334
152tRNA processing (GO:0008033)2.58125231
153regulation of mesoderm development (GO:2000380)2.56560760
154oxidative phosphorylation (GO:0006119)2.51555688
155single strand break repair (GO:0000012)2.50547053
156histone mRNA metabolic process (GO:0008334)2.49655749
157establishment of protein localization to mitochondrion (GO:0072655)2.49174488
158response to pheromone (GO:0019236)2.47567657
159L-methionine salvage (GO:0071267)2.46958960
160L-methionine biosynthetic process (GO:0071265)2.46958960
161amino acid salvage (GO:0043102)2.46958960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.36560761
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.37613884
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.93839413
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.74250659
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.69225881
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.58744299
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.38425062
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.37570604
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32689279
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.25797536
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.13104265
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.07931569
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.91866538
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89021243
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.85393503
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85316263
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84677050
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.63127511
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52343544
20XRN2_22483619_ChIP-Seq_HELA_Human2.47918611
21VDR_23849224_ChIP-Seq_CD4+_Human2.47774045
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43799997
23ZNF274_21170338_ChIP-Seq_K562_Hela2.37778863
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31659199
25* GABP_19822575_ChIP-Seq_HepG2_Human2.30714099
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.26411284
27AR_21909140_ChIP-Seq_LNCAP_Human2.25072893
28* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19468076
29* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16012269
30DCP1A_22483619_ChIP-Seq_HELA_Human2.08285245
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07731350
32FOXP3_21729870_ChIP-Seq_TREG_Human2.02283780
33MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02148992
34TTF2_22483619_ChIP-Seq_HELA_Human1.99392335
35* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97088731
36CIITA_25753668_ChIP-Seq_RAJI_Human1.96174389
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.92189254
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83715353
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.81739457
40EWS_26573619_Chip-Seq_HEK293_Human1.79996719
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79261415
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75863514
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.75503332
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74103147
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73840367
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72537317
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.71661608
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66018904
49VDR_22108803_ChIP-Seq_LS180_Human1.65023994
50FUS_26573619_Chip-Seq_HEK293_Human1.58491753
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53362722
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46786445
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46259747
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46259256
55KDM5A_27292631_Chip-Seq_BREAST_Human1.46088375
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45033298
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.44054375
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43584716
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40609904
60ELK1_19687146_ChIP-ChIP_HELA_Human1.39602798
61* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32827960
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.32644716
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.30829665
64* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30630785
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30445311
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27710998
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27338921
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.27151300
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27140917
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26649882
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26599925
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26324745
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26199066
74IGF1R_20145208_ChIP-Seq_DFB_Human1.26189646
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.25293376
76* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24898065
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23046658
78IRF1_19129219_ChIP-ChIP_H3396_Human1.20361684
79MYC_22102868_ChIP-Seq_BL_Human1.20088664
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18871649
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18313850
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16274614
83SOX2_16153702_ChIP-ChIP_HESCs_Human1.16168329
84MYC_18940864_ChIP-ChIP_HL60_Human1.14888779
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12742746
86P300_19829295_ChIP-Seq_ESCs_Human1.11404506
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11065855
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10906398
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10056307
90TP53_22573176_ChIP-Seq_HFKS_Human1.09637322
91TFEB_21752829_ChIP-Seq_HELA_Human1.09426328
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09221851
93EGR1_19374776_ChIP-ChIP_THP-1_Human1.08609931
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07858305
95TAF15_26573619_Chip-Seq_HEK293_Human1.07847941
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07542584
97NANOG_16153702_ChIP-ChIP_HESCs_Human1.07480968
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04421245
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01350243
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00853986
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.00217689
102FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99936064
103SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99608918
104CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98455220
105* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98303778
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96403965
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96250142
108ELK1_22589737_ChIP-Seq_MCF10A_Human0.96247140
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94093496
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93500414
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92957333
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92884256
113PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92827076
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91636949
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90889692
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90252850
117GBX2_23144817_ChIP-Seq_PC3_Human0.87870083
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87023976
119TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85879519
120PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85367775
121SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84500801
122* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82758970
123CBP_20019798_ChIP-Seq_JUKART_Human0.82566954
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82566954
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82458835
126FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81808406
127* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81115629
128SOX2_19829295_ChIP-Seq_ESCs_Human0.81014675
129NANOG_19829295_ChIP-Seq_ESCs_Human0.81014675
130YY1_22570637_ChIP-Seq_MALME-3M_Human0.80769291
131FOXA1_25329375_ChIP-Seq_VCAP_Human0.80257580
132FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80257580
133BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79488904
134ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.79130556
135RBPJ_22232070_ChIP-Seq_NCS_Mouse0.76813523
136* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.75665437
137TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.73996311
138FOXP1_21924763_ChIP-Seq_HESCs_Human0.73236427
139CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71764380
140SPI1_23547873_ChIP-Seq_NB4_Human0.71441636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.69637098
2MP0003111_abnormal_nucleus_morphology5.01162605
3MP0004957_abnormal_blastocyst_morpholog4.59979139
4* MP0010094_abnormal_chromosome_stability4.43074299
5MP0003077_abnormal_cell_cycle4.19477538
6MP0003718_maternal_effect3.64972914
7MP0008058_abnormal_DNA_repair3.28382394
8MP0008057_abnormal_DNA_replication3.16363219
9MP0008877_abnormal_DNA_methylation3.14176664
10MP0003123_paternal_imprinting2.99802714
11MP0008932_abnormal_embryonic_tissue2.84657183
12MP0008007_abnormal_cellular_replicative2.74226555
13MP0008260_abnormal_autophagy2.52343368
14MP0006292_abnormal_olfactory_placode2.39841609
15MP0001730_embryonic_growth_arrest2.31047090
16MP0000372_irregular_coat_pigmentation2.20930716
17MP0003787_abnormal_imprinting2.11611519
18* MP0000350_abnormal_cell_proliferation2.10281666
19MP0002396_abnormal_hematopoietic_system2.01708462
20MP0003136_yellow_coat_color2.01641987
21MP0005084_abnormal_gallbladder_morpholo1.99406819
22MP0003786_premature_aging1.86454045
23MP0002837_dystrophic_cardiac_calcinosis1.82515589
24MP0003186_abnormal_redox_activity1.76821603
25MP0003315_abnormal_perineum_morphology1.69609966
26MP0002234_abnormal_pharynx_morphology1.69505301
27MP0002163_abnormal_gland_morphology1.66147125
28MP0001697_abnormal_embryo_size1.65403502
29MP0000490_abnormal_crypts_of1.65369497
30* MP0001929_abnormal_gametogenesis1.63275973
31MP0002653_abnormal_ependyma_morphology1.62515352
32MP0005380_embryogenesis_phenotype1.60739394
33MP0001672_abnormal_embryogenesis/_devel1.60739394
34* MP0002210_abnormal_sex_determination1.58308697
35MP0001119_abnormal_female_reproductive1.57170792
36MP0005646_abnormal_pituitary_gland1.56936900
37MP0003121_genomic_imprinting1.56091155
38MP0002102_abnormal_ear_morphology1.54398942
39MP0009046_muscle_twitch1.53810883
40MP0003880_abnormal_central_pattern1.52379710
41MP0002080_prenatal_lethality1.48603881
42MP0001984_abnormal_olfaction1.46741218
43MP0002085_abnormal_embryonic_tissue1.46129828
44* MP0000313_abnormal_cell_death1.42861308
45* MP0000653_abnormal_sex_gland1.42620362
46MP0008875_abnormal_xenobiotic_pharmacok1.42582984
47MP0001529_abnormal_vocalization1.39368047
48MP0005551_abnormal_eye_electrophysiolog1.39083164
49MP0002736_abnormal_nociception_after1.37655344
50MP0010307_abnormal_tumor_latency1.35076983
51MP0002160_abnormal_reproductive_system1.32110571
52* MP0001145_abnormal_male_reproductive1.31475137
53MP0003699_abnormal_female_reproductive1.31374275
54MP0003119_abnormal_digestive_system1.29981879
55MP0001968_abnormal_touch/_nociception1.29455866
56MP0003984_embryonic_growth_retardation1.28602380
57MP0005394_taste/olfaction_phenotype1.27837194
58MP0005499_abnormal_olfactory_system1.27837194
59MP0004133_heterotaxia1.27467692
60MP0005410_abnormal_fertilization1.26496427
61MP0005253_abnormal_eye_physiology1.23932289
62MP0002088_abnormal_embryonic_growth/wei1.23883471
63MP0005451_abnormal_body_composition1.23581395
64* MP0002019_abnormal_tumor_incidence1.22857351
65MP0005389_reproductive_system_phenotype1.21716298
66MP0002084_abnormal_developmental_patter1.19909962
67MP0000358_abnormal_cell_content/1.19281496
68MP0000569_abnormal_digit_pigmentation1.18534952
69MP0005645_abnormal_hypothalamus_physiol1.17119952
70MP0003195_calcinosis1.16700693
71MP0003567_abnormal_fetal_cardiomyocyte1.15396846
72MP0004808_abnormal_hematopoietic_stem1.13685571
73MP0000631_abnormal_neuroendocrine_gland1.12426530
74MP0006036_abnormal_mitochondrial_physio1.10616697
75MP0002233_abnormal_nose_morphology1.10161526
76MP0004142_abnormal_muscle_tone1.09039675
77MP0005395_other_phenotype1.06204217
78MP0001286_abnormal_eye_development1.05007721
79MP0010030_abnormal_orbit_morphology1.04485628
80MP0005379_endocrine/exocrine_gland_phen1.03295195
81MP0006035_abnormal_mitochondrial_morpho0.99946570
82MP0006054_spinal_hemorrhage0.99220016
83MP0005187_abnormal_penis_morphology0.97583003
84MP0002272_abnormal_nervous_system0.96978496
85MP0003221_abnormal_cardiomyocyte_apopto0.96433985
86MP0003656_abnormal_erythrocyte_physiolo0.96360217
87MP0000647_abnormal_sebaceous_gland0.95853917
88* MP0002161_abnormal_fertility/fecundity0.95492472
89MP0002086_abnormal_extraembryonic_tissu0.94049116
90MP0003890_abnormal_embryonic-extraembry0.92857728
91MP0000537_abnormal_urethra_morphology0.91924941
92MP0002638_abnormal_pupillary_reflex0.91241124
93MP0009333_abnormal_splenocyte_physiolog0.91179912
94MP0004215_abnormal_myocardial_fiber0.90644418
95MP0003122_maternal_imprinting0.90475561
96MP0009745_abnormal_behavioral_response0.90169849
97MP0008872_abnormal_physiological_respon0.89379812
98MP0005174_abnormal_tail_pigmentation0.89008217
99MP0008775_abnormal_heart_ventricle0.88871976
100MP0001545_abnormal_hematopoietic_system0.87168442
101MP0005397_hematopoietic_system_phenotyp0.87168442
102MP0001188_hyperpigmentation0.87155496
103MP0003646_muscle_fatigue0.86902530
104MP0005384_cellular_phenotype0.86825850
105MP0005391_vision/eye_phenotype0.86163296
106MP0009697_abnormal_copulation0.83799500
107MP0003938_abnormal_ear_development0.83463052
108MP0002928_abnormal_bile_duct0.82934758
109MP0001905_abnormal_dopamine_level0.82451422
110MP0001919_abnormal_reproductive_system0.81105622
111MP0004147_increased_porphyrin_level0.80809123
112MP0001293_anophthalmia0.80325830
113MP0001764_abnormal_homeostasis0.78917836
114MP0006276_abnormal_autonomic_nervous0.78703861
115MP0009672_abnormal_birth_weight0.77289468
116MP0002932_abnormal_joint_morphology0.77122127
117MP0004197_abnormal_fetal_growth/weight/0.76336372
118MP0002132_abnormal_respiratory_system0.76241928
119MP0006072_abnormal_retinal_apoptosis0.75313087
120MP0005621_abnormal_cell_physiology0.75040725
121MP0003937_abnormal_limbs/digits/tail_de0.74283106
122MP0001485_abnormal_pinna_reflex0.74093347
123MP0005408_hypopigmentation0.73626787
124MP0002090_abnormal_vision0.73080414
125MP0002697_abnormal_eye_size0.72392460
126* MP0000703_abnormal_thymus_morphology0.70885613
127MP0005220_abnormal_exocrine_pancreas0.69387715
128MP0000428_abnormal_craniofacial_morphol0.68611996
129* MP0003698_abnormal_male_reproductive0.68517636
130MP0002938_white_spotting0.68473791
131* MP0002398_abnormal_bone_marrow0.66303253
132MP0002722_abnormal_immune_system0.66211919
133MP0002751_abnormal_autonomic_nervous0.66000002
134MP0002269_muscular_atrophy0.63681212
135* MP0003763_abnormal_thymus_physiology0.61333418
136MP0004264_abnormal_extraembryonic_tissu0.58351942
137MP0005670_abnormal_white_adipose0.57675887
138* MP0000689_abnormal_spleen_morphology0.57223934
139MP0000049_abnormal_middle_ear0.57039147
140MP0000678_abnormal_parathyroid_gland0.56420460
141MP0008995_early_reproductive_senescence0.53645912
142MP0002111_abnormal_tail_morphology0.52405878
143MP0003861_abnormal_nervous_system0.51904375
144* MP0002429_abnormal_blood_cell0.51059458
145MP0000566_synostosis0.48855707
146MP0008789_abnormal_olfactory_epithelium0.48744857

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.82760851
2Carpal bone hypoplasia (HP:0001498)4.89023078
3Breast hypoplasia (HP:0003187)4.66279829
4Cerebral hypomyelination (HP:0006808)4.39225260
5Premature ovarian failure (HP:0008209)4.28692990
6Degeneration of anterior horn cells (HP:0002398)4.23600779
7Abnormality of the anterior horn cell (HP:0006802)4.23600779
8Aplastic anemia (HP:0001915)3.95045304
9Patellar aplasia (HP:0006443)3.91493420
10Aplasia/Hypoplasia of the patella (HP:0006498)3.72439140
11Acute necrotizing encephalopathy (HP:0006965)3.60775429
12Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.55669297
13Oral leukoplakia (HP:0002745)3.51616569
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.42697921
15Abnormality of alanine metabolism (HP:0010916)3.42697921
16Hyperalaninemia (HP:0003348)3.42697921
17Abnormal mitochondria in muscle tissue (HP:0008316)3.40531261
18Rough bone trabeculation (HP:0100670)3.38202173
19Increased CSF lactate (HP:0002490)3.37248003
20Hepatocellular necrosis (HP:0001404)3.32534603
21Microretrognathia (HP:0000308)3.30340427
22Mitochondrial inheritance (HP:0001427)3.29680604
23Secondary amenorrhea (HP:0000869)3.18351440
24Acute encephalopathy (HP:0006846)3.12002217
25Progressive macrocephaly (HP:0004481)3.08637811
26Meckel diverticulum (HP:0002245)3.08031847
27Chromsome breakage (HP:0040012)3.05932058
28Abnormality of the ileum (HP:0001549)3.03527513
29Hepatic necrosis (HP:0002605)3.01708875
30Supernumerary spleens (HP:0009799)3.00761484
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93675681
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.89937352
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.89937352
34CNS hypomyelination (HP:0003429)2.85887227
35Abnormality of the labia minora (HP:0012880)2.84403433
36Selective tooth agenesis (HP:0001592)2.81746959
37Abnormality of the preputium (HP:0100587)2.81437422
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.80892435
39Abnormality of chromosome stability (HP:0003220)2.80826754
40Impulsivity (HP:0100710)2.74490932
41Medial flaring of the eyebrow (HP:0010747)2.72920759
42Unsteady gait (HP:0002317)2.72507690
43Pancreatic fibrosis (HP:0100732)2.69544780
44Pancreatic cysts (HP:0001737)2.61726314
45Lipid accumulation in hepatocytes (HP:0006561)2.61648203
46Duodenal stenosis (HP:0100867)2.60655710
47Small intestinal stenosis (HP:0012848)2.60655710
48Absent radius (HP:0003974)2.60571130
493-Methylglutaconic aciduria (HP:0003535)2.57550396
50Abnormality of the heme biosynthetic pathway (HP:0010472)2.56252498
51Hyperglycinemia (HP:0002154)2.53970611
52Atrophy/Degeneration involving motor neurons (HP:0007373)2.51956668
53Cerebral edema (HP:0002181)2.51864125
54Increased hepatocellular lipid droplets (HP:0006565)2.51789298
55Colon cancer (HP:0003003)2.51242105
56Molar tooth sign on MRI (HP:0002419)2.47705692
57Abnormality of midbrain morphology (HP:0002418)2.47705692
58Abnormal number of erythroid precursors (HP:0012131)2.47287209
59Sclerocornea (HP:0000647)2.46556590
60Myelodysplasia (HP:0002863)2.45847354
61True hermaphroditism (HP:0010459)2.43758227
62Nephronophthisis (HP:0000090)2.43607774
63Aplasia/Hypoplasia of the sternum (HP:0006714)2.43213661
64Abnormal number of incisors (HP:0011064)2.41015229
65Aplasia involving forearm bones (HP:0009822)2.40451317
66Absent forearm bone (HP:0003953)2.40451317
67Abnormality of cells of the erythroid lineage (HP:0012130)2.38900529
68Hypoplasia of the capital femoral epiphysis (HP:0003090)2.36532103
69Bone marrow hypocellularity (HP:0005528)2.34168359
70Calcaneovalgus deformity (HP:0001848)2.32106176
71Rhabdomyosarcoma (HP:0002859)2.31059671
72Abnormal trabecular bone morphology (HP:0100671)2.31013912
73Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30276456
74Horseshoe kidney (HP:0000085)2.29698017
75Lactic acidosis (HP:0003128)2.25634002
76Delusions (HP:0000746)2.24673484
77Neoplasm of the pancreas (HP:0002894)2.24157469
78Reticulocytopenia (HP:0001896)2.23112362
79Progressive muscle weakness (HP:0003323)2.22446253
80Flat capital femoral epiphysis (HP:0003370)2.21914736
81Sloping forehead (HP:0000340)2.20411469
82Muscle fiber atrophy (HP:0100295)2.20141406
83Premature graying of hair (HP:0002216)2.19480498
84Slender long bone (HP:0003100)2.17946112
85Abnormal spermatogenesis (HP:0008669)2.16977060
86Abnormal protein N-linked glycosylation (HP:0012347)2.16300826
87Abnormal protein glycosylation (HP:0012346)2.16300826
88Abnormal glycosylation (HP:0012345)2.16300826
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16300826
90Deformed tarsal bones (HP:0008119)2.16092412
91Type 2 muscle fiber atrophy (HP:0003554)2.15766502
92Renal Fanconi syndrome (HP:0001994)2.15705857
93Absent thumb (HP:0009777)2.14923241
94Abnormality of the duodenum (HP:0002246)2.12407838
95Increased serum pyruvate (HP:0003542)2.12049717
96Cellular immunodeficiency (HP:0005374)2.11184338
97Abnormal lung lobation (HP:0002101)2.11115754
98Facial hemangioma (HP:0000329)2.09031754
99Overlapping toe (HP:0001845)2.07031795
100Hyperglycinuria (HP:0003108)2.06535612
101Multiple enchondromatosis (HP:0005701)2.06154200
102Medulloblastoma (HP:0002885)2.06115195
103Methylmalonic acidemia (HP:0002912)2.05886670
104Respiratory failure (HP:0002878)2.04256986
105Ependymoma (HP:0002888)2.03520814
106Tracheoesophageal fistula (HP:0002575)2.01624719
107Triphalangeal thumb (HP:0001199)2.00619987
108Tubulointerstitial nephritis (HP:0001970)2.00574468
109Irregular epiphyses (HP:0010582)2.00169259
110Male infertility (HP:0003251)1.99864451
111Abnormality of the renal medulla (HP:0100957)1.99490985
112Anophthalmia (HP:0000528)1.97438053
113Pancytopenia (HP:0001876)1.96908171
114Abnormality of glycine metabolism (HP:0010895)1.95600966
115Abnormality of serine family amino acid metabolism (HP:0010894)1.95600966
116Congenital primary aphakia (HP:0007707)1.95540295
117Hypoplasia of the uterus (HP:0000013)1.95486701
118Pendular nystagmus (HP:0012043)1.95163824
119Abnormality of the renal cortex (HP:0011035)1.94967853
120Trismus (HP:0000211)1.94174157
121Diastasis recti (HP:0001540)1.93845820
122Aplasia/hypoplasia of the uterus (HP:0008684)1.93059309
123Type II lissencephaly (HP:0007260)1.92452732
124Abnormality of glycolysis (HP:0004366)1.90949248
125Azoospermia (HP:0000027)1.90534784
126Increased serum lactate (HP:0002151)1.88944878
127Gait imbalance (HP:0002141)1.88156104
128Abnormality of serum amino acid levels (HP:0003112)1.88109621
129Abdominal situs inversus (HP:0003363)1.87159152
130Abnormality of abdominal situs (HP:0011620)1.87159152
131Breast aplasia (HP:0100783)1.87152085
132Personality changes (HP:0000751)1.86873932
133Preaxial hand polydactyly (HP:0001177)1.86780790
134Reduced antithrombin III activity (HP:0001976)1.86378181
135Type I transferrin isoform profile (HP:0003642)1.85655604
136Short middle phalanx of the 5th finger (HP:0004220)1.85109741
137Postnatal microcephaly (HP:0005484)1.84950151
138Volvulus (HP:0002580)1.83687974
139Abnormality of the carotid arteries (HP:0005344)1.83070809
140Aplasia/Hypoplasia of the breasts (HP:0010311)1.82289933
141Retinal dysplasia (HP:0007973)1.81607822
142Microvesicular hepatic steatosis (HP:0001414)1.80628211
143Death in infancy (HP:0001522)1.80609413
144Breech presentation (HP:0001623)1.79606122
145Optic disc pallor (HP:0000543)1.79254036
146Renal cortical cysts (HP:0000803)1.78301836
147Abnormality of cochlea (HP:0000375)1.77723792
148Congenital stationary night blindness (HP:0007642)1.77648697
149Aplasia/Hypoplasia involving the musculature (HP:0001460)1.76368715
150Cafe-au-lait spot (HP:0000957)1.76011229
151Capillary hemangiomas (HP:0005306)1.74884837
152Methylmalonic aciduria (HP:0012120)1.74142831
153Increased intramyocellular lipid droplets (HP:0012240)1.73771631
154Exercise intolerance (HP:0003546)1.73366040
155Cleft eyelid (HP:0000625)1.73349033
156Atresia of the external auditory canal (HP:0000413)1.73176252
157CNS demyelination (HP:0007305)1.72081207
158Abnormality of the umbilical cord (HP:0010881)1.71959076
159Lethargy (HP:0001254)1.71865852
160Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71734699
161Absent epiphyses (HP:0010577)1.71734699
162Vaginal atresia (HP:0000148)1.67798876
163Genital tract atresia (HP:0001827)1.66520194
164Concave nail (HP:0001598)1.65749171
165Nephrogenic diabetes insipidus (HP:0009806)1.65102395
166Small hand (HP:0200055)1.64926229
167Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.63932703
168Adrenal hypoplasia (HP:0000835)1.62878477
169Chronic hepatic failure (HP:0100626)1.60451782
170Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.60355983
171Aplasia/Hypoplasia of the fovea (HP:0008060)1.60046882

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.17724815
2WEE14.27323492
3EIF2AK14.04621911
4MAP4K23.08825911
5CDC73.00754536
6STK162.96526987
7TTK2.93600505
8ACVR1B2.86338201
9BRSK22.51645510
10NUAK12.51265311
11PLK42.50126229
12VRK22.48528863
13NEK22.44279068
14FRK2.43974319
15PLK12.32155174
16BMPR1B2.31161055
17BRAF2.18716575
18MST42.14863545
19ARAF2.14204436
20EIF2AK32.11292905
21PBK2.08179912
22SRPK11.97554488
23BRSK11.97332233
24TSSK61.90612598
25AURKA1.81425331
26DYRK31.80823028
27VRK11.79722341
28MAP3K41.78982466
29PLK31.75245181
30NEK11.73139384
31CDK81.65904095
32AURKB1.62246091
33MOS1.61708595
34LATS21.59972309
35CHEK21.58366440
36TIE11.56608662
37NME21.54360576
38TLK11.53715154
39TRIM281.51711955
40CDK71.42684689
41MKNK11.34611094
42PLK21.29456338
43ATR1.25834233
44PASK1.20244778
45INSRR1.19018832
46STK38L1.14639448
47MAP3K61.13010994
48GRK11.09458791
49CCNB11.08878783
50ZAK1.05869432
51MKNK21.04741725
52MAP3K81.03410426
53MAPK131.03337950
54PIM21.02406296
55TESK21.02115501
56CDK40.99149608
57TGFBR10.98654029
58STK100.98259309
59EIF2AK20.96332825
60RAF10.96129844
61DYRK20.94728819
62NME10.93841187
63BCR0.93676204
64MELK0.93132668
65CHEK10.91807893
66MAPKAPK30.89307256
67ERBB30.89062386
68TNIK0.85742976
69CSNK1A1L0.84939876
70TESK10.84090042
71SCYL20.83535557
72RPS6KA40.79038179
73PHKG10.75930172
74PHKG20.75930172
75BMPR20.75752226
76CASK0.74871706
77RPS6KB20.74712729
78PDK20.73657784
79EPHA20.72046451
80KSR10.68978764
81MAP4K10.68255204
82EPHA40.64980783
83PAK10.64150143
84CDK20.62405271
85CDK190.61538895
86PRKCG0.60400935
87CSNK2A10.59093345
88ERBB40.58588282
89CSNK2A20.57863502
90ATM0.57803657
91MAP3K90.56601261
92TAF10.55475642
93LIMK10.54902058
94BCKDK0.54873930
95CSNK1G30.54483248
96CDK10.53517271
97PAK40.52820545
98EEF2K0.52335982
99PRKCI0.51555352
100MAPKAPK50.48614355
101KSR20.45571244
102MAP3K120.44805763
103DAPK10.42207847
104MAP2K20.41550272
105KDR0.40146343
106MARK30.39869202
107AKT20.39529404
108BRD40.39444601
109CSNK1A10.39206932
110CSNK1G10.38946781
111AKT30.38811451
112MINK10.38042932
113PNCK0.36631075
114OXSR10.36422795
115CSNK1D0.36060342
116FLT30.35873735
117ADRBK10.35465542
118PRKACB0.34658879
119PAK30.34517020
120MAP3K100.34191998
121PRKCE0.33921645
122CAMK2A0.33369919
123MAP2K70.33314262
124NLK0.31827766
125STK30.30182586
126PIM10.30064277
127TAOK30.29095519
128MUSK0.27836211
129STK240.27291229
130MAPK110.26833399
131CSNK1E0.25176654
132WNK30.23922140
133CAMKK20.23909454
134RPS6KA50.23648799
135ABL20.21624821
136CSNK1G20.21350975
137PINK10.20656207
138KIT0.19512192
139ADRBK20.19505912
140MAP3K110.19207931
141STK40.18749028
142ZAP700.18712007

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.77048857
2RNA polymerase_Homo sapiens_hsa030204.12582596
3Mismatch repair_Homo sapiens_hsa034303.84751231
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.74091431
5Proteasome_Homo sapiens_hsa030503.55191585
6Base excision repair_Homo sapiens_hsa034103.34803130
7Homologous recombination_Homo sapiens_hsa034403.21798044
8RNA transport_Homo sapiens_hsa030133.18635972
9Cell cycle_Homo sapiens_hsa041103.08675818
10Spliceosome_Homo sapiens_hsa030403.06376939
11Pyrimidine metabolism_Homo sapiens_hsa002402.89404852
12Nucleotide excision repair_Homo sapiens_hsa034202.69927266
13Ribosome_Homo sapiens_hsa030102.60767147
14Basal transcription factors_Homo sapiens_hsa030222.49573859
15Caffeine metabolism_Homo sapiens_hsa002322.48447147
16RNA degradation_Homo sapiens_hsa030182.27433712
17Fanconi anemia pathway_Homo sapiens_hsa034602.13784177
18Folate biosynthesis_Homo sapiens_hsa007902.12244604
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07232128
20Vitamin B6 metabolism_Homo sapiens_hsa007501.94092139
21Purine metabolism_Homo sapiens_hsa002301.74478057
22Non-homologous end-joining_Homo sapiens_hsa034501.74261981
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70706427
24One carbon pool by folate_Homo sapiens_hsa006701.62533707
25p53 signaling pathway_Homo sapiens_hsa041151.60543980
26Oocyte meiosis_Homo sapiens_hsa041141.54448958
27Alzheimers disease_Homo sapiens_hsa050101.49456382
28mRNA surveillance pathway_Homo sapiens_hsa030151.46542877
29Phototransduction_Homo sapiens_hsa047441.42000433
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41863309
31Fatty acid elongation_Homo sapiens_hsa000621.41243550
32Propanoate metabolism_Homo sapiens_hsa006401.32474655
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28257530
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28112691
35Cardiac muscle contraction_Homo sapiens_hsa042601.27228323
36Regulation of autophagy_Homo sapiens_hsa041401.20854584
37Epstein-Barr virus infection_Homo sapiens_hsa051691.19807186
38Steroid biosynthesis_Homo sapiens_hsa001001.16845921
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16635797
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.14377768
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11605828
42Pyruvate metabolism_Homo sapiens_hsa006201.09476273
43Protein export_Homo sapiens_hsa030601.09325847
44Butanoate metabolism_Homo sapiens_hsa006501.09257813
45Sulfur relay system_Homo sapiens_hsa041221.08770265
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07802088
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04799134
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00096869
49Nicotine addiction_Homo sapiens_hsa050330.99830483
50Thyroid cancer_Homo sapiens_hsa052160.93112311
51Nitrogen metabolism_Homo sapiens_hsa009100.90862519
52Tryptophan metabolism_Homo sapiens_hsa003800.89379507
53Peroxisome_Homo sapiens_hsa041460.85807624
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.84009221
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.79546284
56Biosynthesis of amino acids_Homo sapiens_hsa012300.77532026
57Sulfur metabolism_Homo sapiens_hsa009200.73220371
58Huntingtons disease_Homo sapiens_hsa050160.69486799
59Olfactory transduction_Homo sapiens_hsa047400.69185034
60Pentose phosphate pathway_Homo sapiens_hsa000300.68463983
61Linoleic acid metabolism_Homo sapiens_hsa005910.66302180
62Herpes simplex infection_Homo sapiens_hsa051680.65754830
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63353468
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63143107
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62538828
66Viral carcinogenesis_Homo sapiens_hsa052030.62249793
67Systemic lupus erythematosus_Homo sapiens_hsa053220.60988602
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60742935
69beta-Alanine metabolism_Homo sapiens_hsa004100.56677953
70Circadian rhythm_Homo sapiens_hsa047100.56000970
71HTLV-I infection_Homo sapiens_hsa051660.54814713
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.54301662
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54249069
74Collecting duct acid secretion_Homo sapiens_hsa049660.54220697
75Parkinsons disease_Homo sapiens_hsa050120.51281998
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50846439
77Vitamin digestion and absorption_Homo sapiens_hsa049770.50393907
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50372977
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50164832
80Fatty acid metabolism_Homo sapiens_hsa012120.48444629
81Taste transduction_Homo sapiens_hsa047420.47862272
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46182984
83Synaptic vesicle cycle_Homo sapiens_hsa047210.45637517
84N-Glycan biosynthesis_Homo sapiens_hsa005100.45537105
85Fructose and mannose metabolism_Homo sapiens_hsa000510.44152582
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41762216
87Chemical carcinogenesis_Homo sapiens_hsa052040.40853061
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40163594
89Selenocompound metabolism_Homo sapiens_hsa004500.39474493
90Retinol metabolism_Homo sapiens_hsa008300.37744567
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37340888
92Metabolic pathways_Homo sapiens_hsa011000.36411154
93Fatty acid degradation_Homo sapiens_hsa000710.35544369
94Colorectal cancer_Homo sapiens_hsa052100.35418501
95Lysine degradation_Homo sapiens_hsa003100.35340353
96Oxidative phosphorylation_Homo sapiens_hsa001900.35034293
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34825829
98Galactose metabolism_Homo sapiens_hsa000520.32594397
99Hippo signaling pathway_Homo sapiens_hsa043900.31962558
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.30267031
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30239948
102Alcoholism_Homo sapiens_hsa050340.30196568
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29274065
104Ether lipid metabolism_Homo sapiens_hsa005650.29225380
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29132176
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27902175
107MicroRNAs in cancer_Homo sapiens_hsa052060.27657775
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27636376
109Apoptosis_Homo sapiens_hsa042100.27464510
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27458541
111Tyrosine metabolism_Homo sapiens_hsa003500.27222581
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27170887
113Other glycan degradation_Homo sapiens_hsa005110.26180254
114Arachidonic acid metabolism_Homo sapiens_hsa005900.25878571
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22525540
116Antigen processing and presentation_Homo sapiens_hsa046120.22242248
117Legionellosis_Homo sapiens_hsa051340.22062157
118Carbon metabolism_Homo sapiens_hsa012000.20257232
119Hepatitis B_Homo sapiens_hsa051610.18299777
120Glutathione metabolism_Homo sapiens_hsa004800.18182200
121TGF-beta signaling pathway_Homo sapiens_hsa043500.17606393
122mTOR signaling pathway_Homo sapiens_hsa041500.17001873
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.16863808
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15752840
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15696436
126Notch signaling pathway_Homo sapiens_hsa043300.14452472
127Bladder cancer_Homo sapiens_hsa052190.14082663
128Arginine and proline metabolism_Homo sapiens_hsa003300.13814862
129Hedgehog signaling pathway_Homo sapiens_hsa043400.13623488
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10262904
131Small cell lung cancer_Homo sapiens_hsa052220.10233288
132Shigellosis_Homo sapiens_hsa051310.09485785
133Basal cell carcinoma_Homo sapiens_hsa052170.09228596
134FoxO signaling pathway_Homo sapiens_hsa040680.08466679
135Ovarian steroidogenesis_Homo sapiens_hsa049130.07159348
136HIF-1 signaling pathway_Homo sapiens_hsa040660.05873472
137Pathways in cancer_Homo sapiens_hsa052000.05328423
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.05012636
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.04472706
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.04254612
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.03048217
142Wnt signaling pathway_Homo sapiens_hsa043100.00800128

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »