RNFT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.17776869
2lysine catabolic process (GO:0006554)3.99744735
3lysine metabolic process (GO:0006553)3.99744735
4piRNA metabolic process (GO:0034587)3.96962088
5platelet dense granule organization (GO:0060155)3.72409319
6cysteine metabolic process (GO:0006534)3.61335272
7regulation of meiosis I (GO:0060631)3.55990262
8homocysteine metabolic process (GO:0050667)3.54998828
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.52430422
10regulation of protein activation cascade (GO:2000257)3.38605218
11indole-containing compound catabolic process (GO:0042436)3.37761281
12indolalkylamine catabolic process (GO:0046218)3.37761281
13tryptophan catabolic process (GO:0006569)3.37761281
14regulation of complement activation (GO:0030449)3.31160206
15complement activation, alternative pathway (GO:0006957)3.30957084
16synapsis (GO:0007129)3.30704862
17folic acid transport (GO:0015884)3.26643197
18sulfur amino acid catabolic process (GO:0000098)3.26327523
19peptidyl-glutamic acid carboxylation (GO:0017187)3.24854706
20protein carboxylation (GO:0018214)3.24854706
21tryptophan metabolic process (GO:0006568)3.24385676
22respiratory chain complex IV assembly (GO:0008535)3.18418824
23triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.17041703
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.16163305
25negative regulation of fibrinolysis (GO:0051918)3.09596105
26cellular glucuronidation (GO:0052695)3.07304380
27aromatic amino acid family catabolic process (GO:0009074)3.07146763
28regulation of fibrinolysis (GO:0051917)3.05803441
29serine family amino acid biosynthetic process (GO:0009070)3.04860891
30S-adenosylmethionine metabolic process (GO:0046500)3.03948258
31serine family amino acid catabolic process (GO:0009071)3.02361878
32glycine metabolic process (GO:0006544)2.98098053
33kynurenine metabolic process (GO:0070189)2.96479649
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.95781570
35L-phenylalanine catabolic process (GO:0006559)2.95781570
36bile acid biosynthetic process (GO:0006699)2.93988790
37glyoxylate metabolic process (GO:0046487)2.90023381
38serine family amino acid metabolic process (GO:0009069)2.87915917
39L-phenylalanine metabolic process (GO:0006558)2.87846857
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.87846857
41fibrinolysis (GO:0042730)2.84474291
42anterograde synaptic vesicle transport (GO:0048490)2.83796190
43response to interferon-beta (GO:0035456)2.83020300
44DNA methylation involved in gamete generation (GO:0043046)2.82683140
45urea cycle (GO:0000050)2.81655171
46urea metabolic process (GO:0019627)2.81655171
47signal peptide processing (GO:0006465)2.81362224
48cytochrome complex assembly (GO:0017004)2.80328493
49urate metabolic process (GO:0046415)2.79638695
50regulation of plasminogen activation (GO:0010755)2.76805367
51amino-acid betaine metabolic process (GO:0006577)2.75995948
52uronic acid metabolic process (GO:0006063)2.75979954
53glucuronate metabolic process (GO:0019585)2.75979954
54xenobiotic catabolic process (GO:0042178)2.75709997
55AMP metabolic process (GO:0046033)2.75363097
56folic acid metabolic process (GO:0046655)2.75230950
57DNA deamination (GO:0045006)2.72996666
58UDP-N-acetylglucosamine metabolic process (GO:0006047)2.70462725
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.70261824
60regulation of cellular amino acid metabolic process (GO:0006521)2.69818564
61aldehyde catabolic process (GO:0046185)2.69138376
62ubiquinone biosynthetic process (GO:0006744)2.68010808
63protein neddylation (GO:0045116)2.67692024
64positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.66647027
65positive regulation of hemostasis (GO:1900048)2.61703674
66positive regulation of blood coagulation (GO:0030194)2.61703674
67low-density lipoprotein particle remodeling (GO:0034374)2.61703221
68cullin deneddylation (GO:0010388)2.61534476
69C-terminal protein lipidation (GO:0006501)2.60090784
70positive regulation of interferon-beta production (GO:0032728)2.59986038
71valine metabolic process (GO:0006573)2.59695287
72nucleotide-sugar biosynthetic process (GO:0009226)2.57591453
73positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.56483945
74response to nitrosative stress (GO:0051409)2.56006314
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.54515887
76bile acid and bile salt transport (GO:0015721)2.53117948
77purine-containing compound salvage (GO:0043101)2.52749958
78mannosylation (GO:0097502)2.51651369
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.51503373
80high-density lipoprotein particle remodeling (GO:0034375)2.50617325
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50333666
82neutrophil activation (GO:0042119)2.49246601
83preassembly of GPI anchor in ER membrane (GO:0016254)2.49127304
84bile acid metabolic process (GO:0008206)2.48883857
85regulation of triglyceride catabolic process (GO:0010896)2.48722969
86male meiosis I (GO:0007141)2.48455439
87protein complex biogenesis (GO:0070271)2.48359120
88nucleotide transmembrane transport (GO:1901679)2.47901514
89alpha-linolenic acid metabolic process (GO:0036109)2.47681928
90L-serine metabolic process (GO:0006563)2.47676937
91positive regulation of coagulation (GO:0050820)2.47489537
92regulation of humoral immune response (GO:0002920)2.47484932
93negative regulation of lipid storage (GO:0010888)2.46245567
94regulation of cholesterol homeostasis (GO:2000188)2.45306560
95positive regulation of natural killer cell differentiation (GO:0032825)2.44712033
96regulation of metalloenzyme activity (GO:0048552)2.44386719
97protein K6-linked ubiquitination (GO:0085020)2.43640960
98nitrogen cycle metabolic process (GO:0071941)2.43273039
99plasma lipoprotein particle remodeling (GO:0034369)2.43078856
100protein-lipid complex remodeling (GO:0034368)2.43078856
101macromolecular complex remodeling (GO:0034367)2.43078856
102one-carbon metabolic process (GO:0006730)2.43074081
103branched-chain amino acid catabolic process (GO:0009083)2.42343818
104DNA ligation (GO:0006266)2.41658311
105signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.41581602
106signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.41581602
107signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.41581602
108response to interferon-alpha (GO:0035455)2.41567487
109sulfur amino acid metabolic process (GO:0000096)2.41264842
110immunoglobulin mediated immune response (GO:0016064)2.39913059
111intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.39343891
112signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.39343891
113GPI anchor metabolic process (GO:0006505)2.39312326
114neutrophil activation involved in immune response (GO:0002283)2.38727185
115short-chain fatty acid metabolic process (GO:0046459)2.38082069
116cellular response to interferon-beta (GO:0035458)2.37430015
117branched-chain amino acid metabolic process (GO:0009081)2.37121186
118mitochondrial respiratory chain complex assembly (GO:0033108)2.37031333
119complement activation (GO:0006956)2.35310852
120centriole replication (GO:0007099)2.34895386
121benzene-containing compound metabolic process (GO:0042537)2.33737042
122protein deneddylation (GO:0000338)2.33410459
123alpha-amino acid catabolic process (GO:1901606)2.32634016
124IMP metabolic process (GO:0046040)2.32474621
125DNA double-strand break processing (GO:0000729)2.32304497
126plasma lipoprotein particle clearance (GO:0034381)2.31059561
127anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.31029726
128GPI anchor biosynthetic process (GO:0006506)2.30687502
129regulation of cholesterol esterification (GO:0010872)2.30291724
130positive regulation of interferon-alpha production (GO:0032727)2.28993215
131ubiquinone metabolic process (GO:0006743)2.28755506
132mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.27351329
133mitochondrial respiratory chain complex I assembly (GO:0032981)2.27351329
134NADH dehydrogenase complex assembly (GO:0010257)2.27351329
135antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.26748668
136aromatic amino acid family metabolic process (GO:0009072)2.26685899
137resolution of meiotic recombination intermediates (GO:0000712)2.26147695
138hepatocyte apoptotic process (GO:0097284)2.26086474
139purine nucleobase metabolic process (GO:0006144)2.25845174
140L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.25269474
141quinone biosynthetic process (GO:1901663)2.25138046
142tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.25113374
143RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.25113374
144complement activation, classical pathway (GO:0006958)2.24994663
145amine catabolic process (GO:0009310)2.24929497
146cellular biogenic amine catabolic process (GO:0042402)2.24929497
147regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.24238448
148phospholipid efflux (GO:0033700)2.24113496
149cellular response to ethanol (GO:0071361)2.24094435
150C-terminal protein amino acid modification (GO:0018410)2.24080011
151acylglycerol homeostasis (GO:0055090)2.23653388
152triglyceride homeostasis (GO:0070328)2.23653388
153positive regulation of extracellular matrix organization (GO:1903055)2.23447183
154response to peptidoglycan (GO:0032494)2.23396726
155B cell mediated immunity (GO:0019724)2.23098690
156purine nucleobase biosynthetic process (GO:0009113)2.23058012
157signal transduction involved in DNA damage checkpoint (GO:0072422)2.23056676
158signal transduction involved in DNA integrity checkpoint (GO:0072401)2.23056676
159protein K11-linked deubiquitination (GO:0035871)2.22897579
160ethanol oxidation (GO:0006069)2.22533838
161regulation of mast cell activation (GO:0033003)2.22502384
162response to pheromone (GO:0019236)2.22097708
163granulocyte activation (GO:0036230)2.21549834
164male meiosis (GO:0007140)2.21196123
165protein activation cascade (GO:0072376)2.20992521
166negative regulation of interleukin-12 production (GO:0032695)2.20849403
167positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.20395329
168signal transduction involved in cell cycle checkpoint (GO:0072395)2.20153238
169nucleobase biosynthetic process (GO:0046112)2.19651674
170antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.19471112
171opsonization (GO:0008228)2.19344228
172negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.18946624
173negative regulation of ligase activity (GO:0051352)2.18946624
174cellular extravasation (GO:0045123)2.17844923
175protein K11-linked ubiquitination (GO:0070979)2.17604982
176adenosine metabolic process (GO:0046085)2.17289020
177positive regulation of mast cell activation (GO:0033005)2.15747294
178positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.14311659
179DNA catabolic process, exonucleolytic (GO:0000738)2.14273485
180positive regulation of ligase activity (GO:0051351)2.12940512
181reciprocal meiotic recombination (GO:0007131)2.11842137
182reciprocal DNA recombination (GO:0035825)2.11842137
183attachment of spindle microtubules to kinetochore (GO:0008608)2.11349958
184regulation of hypersensitivity (GO:0002883)2.10895529
185neutrophil mediated immunity (GO:0002446)2.10851591
186dopamine transport (GO:0015872)2.10084301
187somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.09795273
188somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.09795273
189isotype switching (GO:0045190)2.09795273
190regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.08421773
191positive regulation of mast cell degranulation (GO:0043306)2.08069069
192positive regulation of mast cell activation involved in immune response (GO:0033008)2.08069069
193meiosis I (GO:0007127)2.07395837
194L-methionine biosynthetic process (GO:0071265)2.06443097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.22717625
2EGR1_23403033_ChIP-Seq_LIVER_Mouse3.65981445
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.59094775
4E2F7_22180533_ChIP-Seq_HELA_Human3.54601256
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.54185711
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.23404807
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.71424575
8GATA1_22025678_ChIP-Seq_K562_Human2.61719729
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.56019490
10IGF1R_20145208_ChIP-Seq_DFB_Human2.55422196
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.48722802
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.48675965
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.43330598
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.29106270
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25822670
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22648529
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.18554871
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.10423005
19ZNF274_21170338_ChIP-Seq_K562_Hela2.07788921
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03518354
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95229749
22CLOCK_20551151_ChIP-Seq_293T_Human1.93247268
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91565369
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.91450916
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90228353
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88556353
27FOXP3_21729870_ChIP-Seq_TREG_Human1.87703705
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.80750718
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79050169
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78120272
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77818346
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.74900380
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74590935
34* ER_23166858_ChIP-Seq_MCF-7_Human1.70039262
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.69172395
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.68837394
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68618654
38EWS_26573619_Chip-Seq_HEK293_Human1.62869368
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62519397
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61569608
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.61067734
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61000619
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60531575
44* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60057042
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59989850
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.58630547
47VDR_22108803_ChIP-Seq_LS180_Human1.57515129
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56611241
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.55311061
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51578778
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.49220587
52TAF15_26573619_Chip-Seq_HEK293_Human1.48950259
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.48872877
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.47105920
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46621409
56FUS_26573619_Chip-Seq_HEK293_Human1.44811040
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.44702242
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44660408
59AR_21909140_ChIP-Seq_LNCAP_Human1.44600161
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43247642
61GATA3_26560356_Chip-Seq_TH2_Human1.41963402
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41187982
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38053992
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36836110
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36415440
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.34433646
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33995811
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32437157
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32419490
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31490516
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31138199
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.29525283
73VDR_23849224_ChIP-Seq_CD4+_Human1.28283396
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27671691
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27411671
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26773354
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25449226
78SPI1_23547873_ChIP-Seq_NB4_Human1.25335516
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24497361
80ELK1_19687146_ChIP-ChIP_HELA_Human1.23171915
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22082746
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20269713
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19327571
84AR_20517297_ChIP-Seq_VCAP_Human1.17915092
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17667137
86E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17467032
87ETS1_20019798_ChIP-Seq_JURKAT_Human1.16794608
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16174646
89FOXA1_25329375_ChIP-Seq_VCAP_Human1.16174646
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15914666
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14842417
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.14822467
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14583794
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12936617
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12621326
96SALL4_22934838_ChIP-ChIP_CD34+_Human1.12058370
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11873981
98CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11675079
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11416587
100* CRX_20693478_ChIP-Seq_RETINA_Mouse1.11093916
101TP53_22573176_ChIP-Seq_HFKS_Human1.10987606
102* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10221289
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.09865974
104PU_27001747_Chip-Seq_BMDM_Mouse1.09761354
105PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09289499
106STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09210312
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08643750
108MYC_18940864_ChIP-ChIP_HL60_Human1.08123893
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.07105025
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05973065
111DCP1A_22483619_ChIP-Seq_HELA_Human1.05939187
112GABP_19822575_ChIP-Seq_HepG2_Human1.05549795
113* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05511377
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05183591
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04841273
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04407289
117P300_19829295_ChIP-Seq_ESCs_Human1.04121087
118NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03451809
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03169053
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03060588
121PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01284922
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01064269
123BCAT_22108803_ChIP-Seq_LS180_Human1.00820827
124HTT_18923047_ChIP-ChIP_STHdh_Human0.99885199
125NANOG_19829295_ChIP-Seq_ESCs_Human0.99394693
126SOX2_19829295_ChIP-Seq_ESCs_Human0.99394693
127NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98359340
128* MYB_26560356_Chip-Seq_TH1_Human0.98185960
129RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95864938
130PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95292999
131CBP_20019798_ChIP-Seq_JUKART_Human0.94493926
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94493926
133LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94368840
134GATA3_27048872_Chip-Seq_THYMUS_Human0.94274954
135ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94171641
136MYB_26560356_Chip-Seq_TH2_Human0.93746801
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92846507
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92165548
139* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92063061
140GATA4_25053715_ChIP-Seq_YYC3_Human0.91057877
141TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90836266
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90364572
143OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89840474
144EGR1_19032775_ChIP-ChIP_M12_Human0.89763158
145* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88540515
146SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88358007
147SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88358007
148ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86901901
149TFEB_21752829_ChIP-Seq_HELA_Human0.84793483
150HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.84785896
151STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.83826185
152CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83692610
153CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82759567
154CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.82503890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.19527233
2MP0005360_urolithiasis3.93558682
3MP0008438_abnormal_cutaneous_collagen3.03231764
4MP0005365_abnormal_bile_salt2.98061069
5MP0005085_abnormal_gallbladder_physiolo2.96189792
6MP0009840_abnormal_foam_cell2.43479993
7MP0003806_abnormal_nucleotide_metabolis2.40415268
8MP0005075_abnormal_melanosome_morpholog2.36990504
9MP0008875_abnormal_xenobiotic_pharmacok2.36060785
10MP0000372_irregular_coat_pigmentation2.28752683
11MP0003705_abnormal_hypodermis_morpholog2.20722924
12MP0005408_hypopigmentation2.17114818
13MP0000569_abnormal_digit_pigmentation2.10219545
14MP0000015_abnormal_ear_pigmentation2.08849437
15MP0005275_abnormal_skin_tensile2.07604378
16MP0001835_abnormal_antigen_presentation2.05669545
17MP0006036_abnormal_mitochondrial_physio1.99697551
18MP0003252_abnormal_bile_duct1.94132149
19MP0003191_abnormal_cellular_cholesterol1.92596918
20MP0008877_abnormal_DNA_methylation1.87039993
21MP0003436_decreased_susceptibility_to1.78149962
22MP0003195_calcinosis1.71645567
23MP0003186_abnormal_redox_activity1.70727222
24MP0008058_abnormal_DNA_repair1.68627316
25MP0010329_abnormal_lipoprotein_level1.67232420
26MP0003279_aneurysm1.66820249
27MP0000465_gastrointestinal_hemorrhage1.64806188
28MP0005174_abnormal_tail_pigmentation1.59795817
29MP0005503_abnormal_tendon_morphology1.59211941
30MP0010094_abnormal_chromosome_stability1.59163590
31MP0005332_abnormal_amino_acid1.58888287
32MP0002166_altered_tumor_susceptibility1.58781040
33MP0002102_abnormal_ear_morphology1.56487230
34MP0006054_spinal_hemorrhage1.49748516
35MP0009785_altered_susceptibility_to1.48789483
36MP0001542_abnormal_bone_strength1.45693613
37MP0001853_heart_inflammation1.44193506
38MP0008057_abnormal_DNA_replication1.37607113
39MP0002006_tumorigenesis1.36879623
40MP0003566_abnormal_cell_adhesion1.35452326
41MP0002396_abnormal_hematopoietic_system1.34965674
42MP0002060_abnormal_skin_morphology1.34800019
43MP0000609_abnormal_liver_physiology1.33488458
44MP0005319_abnormal_enzyme/_coenzyme1.32608005
45MP0002933_joint_inflammation1.31491428
46MP0002876_abnormal_thyroid_physiology1.31423518
47MP0009764_decreased_sensitivity_to1.30860383
48MP0002095_abnormal_skin_pigmentation1.29232825
49MP0002419_abnormal_innate_immunity1.29020793
50MP0003724_increased_susceptibility_to1.28336232
51MP0006035_abnormal_mitochondrial_morpho1.27410328
52MP0004019_abnormal_vitamin_homeostasis1.27270743
53MP0001873_stomach_inflammation1.26799275
54MP0005023_abnormal_wound_healing1.26482556
55MP0008469_abnormal_protein_level1.26148014
56MP0000371_diluted_coat_color1.26108185
57MP0003718_maternal_effect1.25735547
58MP0003786_premature_aging1.24401736
59MP0001666_abnormal_nutrient_absorption1.23749570
60MP0003172_abnormal_lysosome_physiology1.23731194
61MP0002148_abnormal_hypersensitivity_rea1.23446224
62MP0001533_abnormal_skeleton_physiology1.21822652
63MP0009697_abnormal_copulation1.18001500
64MP0001764_abnormal_homeostasis1.17419553
65MP0002138_abnormal_hepatobiliary_system1.17301851
66MP0009384_cardiac_valve_regurgitation1.15641264
67MP0000427_abnormal_hair_cycle1.14501318
68MP0005379_endocrine/exocrine_gland_phen1.14076242
69MP0005671_abnormal_response_to1.14074791
70MP0006082_CNS_inflammation1.13446635
71MP0005670_abnormal_white_adipose1.12911131
72MP0005410_abnormal_fertilization1.12307031
73MP0003646_muscle_fatigue1.11980068
74MP0000685_abnormal_immune_system1.10735564
75MP0005058_abnormal_lysosome_morphology1.10280026
76MP0005025_abnormal_response_to1.09714072
77MP0002254_reproductive_system_inflammat1.08556224
78MP0002452_abnormal_antigen_presenting1.07059908
79MP0001986_abnormal_taste_sensitivity1.06651507
80MP0009763_increased_sensitivity_to1.06554310
81MP0001845_abnormal_inflammatory_respons1.06265523
82MP0004808_abnormal_hematopoietic_stem1.04181963
83MP0001800_abnormal_humoral_immune1.03538421
84MP0004947_skin_inflammation1.03250523
85MP0001243_abnormal_dermal_layer1.02626484
86MP0001958_emphysema1.02531719
87MP0005000_abnormal_immune_tolerance1.02015479
88MP0002009_preneoplasia1.01636494
89MP0008260_abnormal_autophagy1.01392794
90MP0001545_abnormal_hematopoietic_system1.01229042
91MP0005397_hematopoietic_system_phenotyp1.01229042
92MP0010368_abnormal_lymphatic_system1.00565034
93MP0002837_dystrophic_cardiac_calcinosis1.00167199
94MP0010352_gastrointestinal_tract_polyps0.99694446
95MP0002132_abnormal_respiratory_system0.99572037
96MP0005310_abnormal_salivary_gland0.98981736
97MP0002398_abnormal_bone_marrow0.98479290
98MP0000598_abnormal_liver_morphology0.98216055
99MP0004883_abnormal_blood_vessel0.98026671
100MP0005253_abnormal_eye_physiology0.97382098
101MP0000343_altered_response_to0.97229011
102MP0000716_abnormal_immune_system0.96798655
103MP0002723_abnormal_immune_serum0.95125605
104MP0001929_abnormal_gametogenesis0.95041569
105MP0008007_abnormal_cellular_replicative0.93720634
106MP0008995_early_reproductive_senescence0.92909239
107MP0002405_respiratory_system_inflammati0.92895534
108MP0002722_abnormal_immune_system0.92729851
109MP0004147_increased_porphyrin_level0.92591541
110MP0002736_abnormal_nociception_after0.92464730
111MP0003693_abnormal_embryo_hatching0.90680165
112MP0005464_abnormal_platelet_physiology0.89742674
113MP0005083_abnormal_biliary_tract0.88829733
114MP0001324_abnormal_eye_pigmentation0.88565412
115MP0001919_abnormal_reproductive_system0.88460632
116MP0005387_immune_system_phenotype0.87976485
117MP0001790_abnormal_immune_system0.87976485
118MP0008872_abnormal_physiological_respon0.87409368
119MP0003656_abnormal_erythrocyte_physiolo0.87190445
120MP0005390_skeleton_phenotype0.87091888
121MP0010155_abnormal_intestine_physiology0.86512601
122MP0002118_abnormal_lipid_homeostasis0.85609610
123MP0009643_abnormal_urine_homeostasis0.85117626
124MP0000358_abnormal_cell_content/0.84982469
125MP0005647_abnormal_sex_gland0.84356620
126MP0004381_abnormal_hair_follicle0.82068390
127MP0004782_abnormal_surfactant_physiolog0.81519944
128MP0005451_abnormal_body_composition0.81159055
129MP0000858_altered_metastatic_potential0.81133990
130MP0005395_other_phenotype0.80336406
131MP0005164_abnormal_response_to0.79627153
132MP0004484_altered_response_of0.79344779
133MP0000689_abnormal_spleen_morphology0.78447384
134MP0006072_abnormal_retinal_apoptosis0.78209995
135MP0005584_abnormal_enzyme/coenzyme_acti0.77574910
136MP0002420_abnormal_adaptive_immunity0.77520291
137MP0001819_abnormal_immune_cell0.77437059
138MP0009333_abnormal_splenocyte_physiolog0.77039526
139MP0002998_abnormal_bone_remodeling0.75097539
140MP0005166_decreased_susceptibility_to0.74115800
141MP0005084_abnormal_gallbladder_morpholo0.73744256
142MP0003763_abnormal_thymus_physiology0.73481145
143MP0002136_abnormal_kidney_physiology0.72593769
144MP0000490_abnormal_crypts_of0.72338348

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)3.96394104
2Intrahepatic cholestasis (HP:0001406)3.57748760
3Protrusio acetabuli (HP:0003179)3.43181127
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.42015559
5Upper motor neuron abnormality (HP:0002127)3.28613988
6Xanthomatosis (HP:0000991)3.25829261
7Abnormality of the intrinsic pathway (HP:0010989)3.23006770
8Reduced antithrombin III activity (HP:0001976)3.20175424
9Deep venous thrombosis (HP:0002625)3.12234525
10Stomatitis (HP:0010280)3.07452307
11Complement deficiency (HP:0004431)3.02541986
12Premature rupture of membranes (HP:0001788)3.01667500
13Hypoproteinemia (HP:0003075)3.00475744
14B lymphocytopenia (HP:0010976)2.99659874
15Thyroiditis (HP:0100646)2.95910501
16Systemic lupus erythematosus (HP:0002725)2.94694980
173-Methylglutaconic aciduria (HP:0003535)2.92295223
18Acute necrotizing encephalopathy (HP:0006965)2.89936174
19Panhypogammaglobulinemia (HP:0003139)2.89895542
20Abnormality of aromatic amino acid family metabolism (HP:0004338)2.89721397
21Abnormality of B cell number (HP:0010975)2.88513500
22Hypobetalipoproteinemia (HP:0003563)2.87204266
23Abnormality of the common coagulation pathway (HP:0010990)2.86066176
24Mitochondrial inheritance (HP:0001427)2.73866522
25Increased CSF lactate (HP:0002490)2.73309171
26Severe combined immunodeficiency (HP:0004430)2.71781703
27Acute encephalopathy (HP:0006846)2.71142757
28Progressive macrocephaly (HP:0004481)2.70276167
29Biconcave vertebral bodies (HP:0004586)2.67632493
30Nonimmune hydrops fetalis (HP:0001790)2.65840694
31Abnormality of glutamine family amino acid metabolism (HP:0010902)2.65017936
32Abnormality of methionine metabolism (HP:0010901)2.64673170
33Proximal tubulopathy (HP:0000114)2.64475946
34Myocardial infarction (HP:0001658)2.62509040
35Abnormality of complement system (HP:0005339)2.61893116
36Recurrent gram-negative bacterial infections (HP:0005420)2.60845955
37Hypolipoproteinemia (HP:0010981)2.60605995
38Hepatic necrosis (HP:0002605)2.60178202
39Abnormal mitochondria in muscle tissue (HP:0008316)2.60015432
40Hypoalphalipoproteinemia (HP:0003233)2.59198501
41Albinism (HP:0001022)2.53857572
42Thrombocytosis (HP:0001894)2.52407384
43Irregular epiphyses (HP:0010582)2.50529875
44Hepatocellular necrosis (HP:0001404)2.50263235
45Fat malabsorption (HP:0002630)2.48495127
46Joint hemorrhage (HP:0005261)2.47591277
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.47311944
48Combined immunodeficiency (HP:0005387)2.46894054
49Hyperglycinemia (HP:0002154)2.43478582
50Hyperlipoproteinemia (HP:0010980)2.42573447
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.42318651
52Abnormal cartilage morphology (HP:0002763)2.41204710
53Abnormality of iron homeostasis (HP:0011031)2.41065764
54Cervical subluxation (HP:0003308)2.39003403
55Osteolytic defects of the hand bones (HP:0009699)2.38723087
56Osteolytic defects of the phalanges of the hand (HP:0009771)2.38723087
57Abnormality of sulfur amino acid metabolism (HP:0004339)2.36313921
58Hyperglycinuria (HP:0003108)2.36105669
59Eczematoid dermatitis (HP:0000976)2.33769297
60Generalized aminoaciduria (HP:0002909)2.32880257
61Hypercholesterolemia (HP:0003124)2.31374079
62Aortic dissection (HP:0002647)2.29354970
63Vacuolated lymphocytes (HP:0001922)2.28397451
64Beaking of vertebral bodies (HP:0004568)2.27532261
65Increased serum ferritin (HP:0003281)2.27163140
66Pustule (HP:0200039)2.25241923
67Abnormality of the renal cortex (HP:0011035)2.25137467
68Vertebral compression fractures (HP:0002953)2.24519141
69Cupped ribs (HP:0000887)2.23702974
70Abnormality of transition element cation homeostasis (HP:0011030)2.23018260
71Abnormality of T cell number (HP:0011839)2.22936900
72Steatorrhea (HP:0002570)2.22787703
73Eosinophilia (HP:0001880)2.22784664
74Pancreatic cysts (HP:0001737)2.22650000
75Abnormality of serum amino acid levels (HP:0003112)2.21767439
76Abnormality of pyrimidine metabolism (HP:0004353)2.20393613
77T lymphocytopenia (HP:0005403)2.20344199
78Abnormality of liposaccharide metabolism (HP:0010968)2.20173102
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.20173102
80Abnormality of glycolipid metabolism (HP:0010969)2.20173102
81Increased hepatocellular lipid droplets (HP:0006565)2.18363382
82Abnormality of the anterior horn cell (HP:0006802)2.18103494
83Degeneration of anterior horn cells (HP:0002398)2.18103494
84Methylmalonic acidemia (HP:0002912)2.16802564
85Lipid accumulation in hepatocytes (HP:0006561)2.16040949
86Renal Fanconi syndrome (HP:0001994)2.14555186
87Hydroxyprolinuria (HP:0003080)2.13343016
88Abnormality of proline metabolism (HP:0010907)2.13343016
89Hyperammonemia (HP:0001987)2.11383696
90Abnormality of the prostate (HP:0008775)2.10926719
91Abnormality of fatty-acid metabolism (HP:0004359)2.10790529
92Recurrent fungal infections (HP:0002841)2.10718243
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10019260
94Abnormality of alanine metabolism (HP:0010916)2.10019260
95Hyperalaninemia (HP:0003348)2.10019260
96Abnormality of eosinophils (HP:0001879)2.09513128
97Cerebral edema (HP:0002181)2.08324890
98Hypochromic anemia (HP:0001931)2.06127370
99Abnormality of serine family amino acid metabolism (HP:0010894)2.05689694
100Abnormality of glycine metabolism (HP:0010895)2.05689694
101Glomerulonephritis (HP:0000099)2.05541891
102Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.05115850
103Degeneration of the lateral corticospinal tracts (HP:0002314)2.05115850
104Hypoplasia of the thymus (HP:0000778)2.02786723
105Progressive muscle weakness (HP:0003323)2.02436774
106Aortic aneurysm (HP:0004942)2.01122328
107Petechiae (HP:0000967)2.01113667
108Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00372494
109Abnormality of nucleobase metabolism (HP:0010932)2.00021065
110Optic neuritis (HP:0100653)1.99918944
111Retrobulbar optic neuritis (HP:0100654)1.99918944
112Loss of speech (HP:0002371)1.99292896
113Recurrent cutaneous fungal infections (HP:0011370)1.99030327
114Chronic mucocutaneous candidiasis (HP:0002728)1.99030327
115Increased serum lactate (HP:0002151)1.98832879
116Lethargy (HP:0001254)1.97288099
117Abnormality of chromosome stability (HP:0003220)1.96454384
118Molar tooth sign on MRI (HP:0002419)1.93872090
119Abnormality of midbrain morphology (HP:0002418)1.93872090
120Lactic acidosis (HP:0003128)1.93495438
121Cardiovascular calcification (HP:0011915)1.93439683
122Abnormal tarsal ossification (HP:0008369)1.91967394
123Exertional dyspnea (HP:0002875)1.91814766
124Abnormality of T cells (HP:0002843)1.90556005
125Granulocytopenia (HP:0001913)1.90430377
126Abnormality of purine metabolism (HP:0004352)1.89834791
127Respiratory failure (HP:0002878)1.88579693
128Prostate neoplasm (HP:0100787)1.88206041
129True hermaphroditism (HP:0010459)1.87874262
130Abnormality of urine glucose concentration (HP:0011016)1.87612042
131Glycosuria (HP:0003076)1.87612042
132Nausea (HP:0002018)1.86372365
133Microcytic anemia (HP:0001935)1.85891690
134Reduced subcutaneous adipose tissue (HP:0003758)1.85578273
135IgA deficiency (HP:0002720)1.85200783
136Abnormal delayed hypersensitivity skin test (HP:0002963)1.85165758
137Type I transferrin isoform profile (HP:0003642)1.84545131
138Renal cortical cysts (HP:0000803)1.84089637
139Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82178116
140Abnormal protein N-linked glycosylation (HP:0012347)1.82178116
141Abnormal protein glycosylation (HP:0012346)1.82178116
142Abnormal glycosylation (HP:0012345)1.82178116
143Abnormality of T cell physiology (HP:0011840)1.81091084
144Disinhibition (HP:0000734)1.80615963
145Short tibia (HP:0005736)1.80559457
146IgG deficiency (HP:0004315)1.80548952
147Recurrent bacterial skin infections (HP:0005406)1.80192372
148Recurrent abscess formation (HP:0002722)1.79096962
149Joint swelling (HP:0001386)1.78813384
150Abnormal foot bone ossification (HP:0010675)1.77960117
151Methylmalonic aciduria (HP:0012120)1.77804318
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.76553706
153Abnormality of macrophages (HP:0004311)1.76069937
154Vascular calcification (HP:0004934)1.76066685
155Volvulus (HP:0002580)1.75963388
156Myositis (HP:0100614)1.75803855
157Neutropenia (HP:0001875)1.75616554
158Recurrent skin infections (HP:0001581)1.74749369
159Epiphyseal dysplasia (HP:0002656)1.74391064
160Hyperbilirubinemia (HP:0002904)1.74359509
161Abnormal delivery (HP:0001787)1.73176194
162Elevated erythrocyte sedimentation rate (HP:0003565)1.73104392
163Hypertriglyceridemia (HP:0002155)1.72624706
164Autoimmune hemolytic anemia (HP:0001890)1.72562369
165Peritonitis (HP:0002586)1.72315766
166Encephalitis (HP:0002383)1.71891330
167Neonatal short-limb short stature (HP:0008921)1.71743873
168Gout (HP:0001997)1.71452760
169Agnosia (HP:0010524)1.71450799
170Gonadal dysgenesis (HP:0000133)1.70442172
171Acute hepatic failure (HP:0006554)1.70350983
172Abnormal number of erythroid precursors (HP:0012131)1.70345332
173Medial flaring of the eyebrow (HP:0010747)1.69914087
174Abnormality of the fovea (HP:0000493)1.69891435
175Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.69886516
176CNS demyelination (HP:0007305)1.69663475
177Atrophy/Degeneration involving motor neurons (HP:0007373)1.69520277
178Epidermoid cyst (HP:0200040)1.68939070
179Conjugated hyperbilirubinemia (HP:0002908)1.67047230
180Abnormality of dicarboxylic acid metabolism (HP:0010995)1.66827380
181Dicarboxylic aciduria (HP:0003215)1.66827380
182Soft skin (HP:0000977)1.66375039
183Spontaneous abortion (HP:0005268)1.66102793
184Hypoglycemic coma (HP:0001325)1.65889885
185Abnormal spermatogenesis (HP:0008669)1.65849160
186Periodontitis (HP:0000704)1.65467887
187Generalized amyotrophy (HP:0003700)1.64258049
188Toxemia of pregnancy (HP:0100603)1.64037117
189Stillbirth (HP:0003826)1.63615981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.01890133
2NME22.43251177
3SIK32.39226520
4BMPR1B2.37853293
5MAP3K142.30131783
6EIF2AK12.27104261
7MST42.17789487
8FLT32.13986432
9ZAK2.13961848
10ERN12.11607163
11PIK3CG2.10216361
12BCKDK2.05693768
13TGFBR22.05303468
14MAP3K122.04358098
15PIM22.03524072
16SCYL22.02593752
17TBK11.90277775
18NEK91.86101424
19BCR1.82489594
20MAP4K21.81758997
21MAP3K31.78367185
22TYK21.75059338
23BUB11.74207714
24SIK11.73318817
25EIF2AK21.69776852
26ACVR1B1.65225495
27FGFR41.59455601
28KIT1.54847584
29KDR1.51525894
30MAP4K11.48887624
31EPHA31.47451172
32MAP2K31.46069038
33RPS6KA41.45597267
34BMPR21.43385745
35TAOK21.41482813
36EIF2AK31.41431738
37BLK1.40405005
38STK101.39597059
39PLK41.38171397
40WEE11.37656929
41CCNB11.36294832
42FRK1.36147254
43IRAK41.34488320
44IKBKE1.32701627
45TRPM71.31531824
46MARK31.29378673
47MKNK21.25628016
48MAPKAPK31.24563645
49PDK21.22748745
50IRAK31.22702607
51TXK1.22553487
52JAK11.21561508
53TEC1.21462913
54PBK1.21343780
55PDK41.20164375
56PDK31.20164375
57INSRR1.15990876
58LATS11.15160511
59IKBKB1.14522722
60JAK31.14186518
61OXSR11.11195639
62CDK81.10060950
63MKNK11.09957472
64STK38L1.08420265
65CSF1R1.04609989
66GRK61.04313529
67BRSK21.02396577
68STK161.01990407
69PIM11.01983873
70WNK31.00737633
71PINK11.00312323
72ADRBK20.97364939
73GRK70.93334462
74NME10.92567610
75PLK30.91720174
76FES0.91556224
77TTN0.91419960
78MUSK0.90971527
79PLK20.90853526
80ZAP700.90727632
81PRKG20.90262660
82TAOK30.89356595
83GRK10.88922988
84PKN20.86556118
85CSNK1G30.85955517
86TGFBR10.83483112
87NUAK10.83361693
88STK30.81121231
89CHUK0.80733566
90CSNK1G10.80638636
91FER0.80241719
92PRKAA20.79962340
93FGFR30.78308174
94CSNK1G20.78137810
95PIK3CA0.77671736
96ERBB30.77621595
97PAK30.77221112
98MAP3K40.76581609
99STK390.75927132
100VRK10.75087707
101SRPK10.74517519
102ERBB40.74039521
103MATK0.73961733
104MAPK130.72186932
105CDK40.71635547
106ABL20.71486022
107LRRK20.70454112
108CAMKK20.69104037
109NLK0.67815957
110TNK20.67501019
111SYK0.67140802
112MAP3K110.66625940
113CLK10.66145119
114FGR0.65437857
115DDR20.64995161
116AURKB0.64367137
117CSNK1A1L0.64199331
118DYRK30.63168722
119TTK0.61449355
120PLK10.61104403
121TNIK0.59735505
122NEK10.58323440
123MAPK110.56953566
124PTK2B0.56609646
125MAP3K50.55903454
126MST1R0.55613570
127CDK60.53972353
128TESK10.53779170
129LYN0.53337494
130IRAK10.52892122
131PRKCQ0.52746393
132MAP2K60.52731919
133NEK60.51938588
134PRKCE0.51352498
135TRIB30.50281610
136MAP3K80.49816456
137MOS0.49578485
138HCK0.49235052
139IGF1R0.48415696
140NEK20.47368451
141LCK0.46268183
142BTK0.45049919
143CSK0.44223780
144DYRK1B0.44092634
145ABL10.43102113
146ITK0.41440715
147CSNK2A10.36339251
148MYLK0.35907087

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.91751676
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.57575256
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.43857429
4Folate biosynthesis_Homo sapiens_hsa007902.36698366
5Non-homologous end-joining_Homo sapiens_hsa034502.34359978
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26318700
7Complement and coagulation cascades_Homo sapiens_hsa046102.24664422
8Fatty acid elongation_Homo sapiens_hsa000622.16047365
9Staphylococcus aureus infection_Homo sapiens_hsa051502.14679216
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.12633521
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.12213749
12Fatty acid degradation_Homo sapiens_hsa000712.09880002
13Caffeine metabolism_Homo sapiens_hsa002322.09675885
14Asthma_Homo sapiens_hsa053102.09480906
15Oxidative phosphorylation_Homo sapiens_hsa001902.03125195
16Selenocompound metabolism_Homo sapiens_hsa004501.92820550
17Propanoate metabolism_Homo sapiens_hsa006401.74997118
18Mismatch repair_Homo sapiens_hsa034301.74487014
19Peroxisome_Homo sapiens_hsa041461.71024860
20Fanconi anemia pathway_Homo sapiens_hsa034601.70857262
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.68854654
22Chemical carcinogenesis_Homo sapiens_hsa052041.67827977
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67268684
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65317700
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64149420
26Regulation of autophagy_Homo sapiens_hsa041401.63194807
27Autoimmune thyroid disease_Homo sapiens_hsa053201.60104195
28Tryptophan metabolism_Homo sapiens_hsa003801.56239059
29RNA polymerase_Homo sapiens_hsa030201.55340658
30Parkinsons disease_Homo sapiens_hsa050121.55061222
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.52825726
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52666167
33Type I diabetes mellitus_Homo sapiens_hsa049401.50952308
34Proteasome_Homo sapiens_hsa030501.50832781
35Rheumatoid arthritis_Homo sapiens_hsa053231.45605158
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.44934406
37PPAR signaling pathway_Homo sapiens_hsa033201.44363809
38DNA replication_Homo sapiens_hsa030301.42006584
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.41444916
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.39189604
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.38271278
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36893006
43Collecting duct acid secretion_Homo sapiens_hsa049661.35028116
44Vitamin digestion and absorption_Homo sapiens_hsa049771.31699889
45Arginine biosynthesis_Homo sapiens_hsa002201.30119667
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28910517
47Pyruvate metabolism_Homo sapiens_hsa006201.28514289
48One carbon pool by folate_Homo sapiens_hsa006701.26384927
49Retinol metabolism_Homo sapiens_hsa008301.25681354
50Starch and sucrose metabolism_Homo sapiens_hsa005001.24713903
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24675765
52Basal transcription factors_Homo sapiens_hsa030221.23983926
53Fatty acid metabolism_Homo sapiens_hsa012121.23211235
54Pentose phosphate pathway_Homo sapiens_hsa000301.21833623
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20290101
56Glutathione metabolism_Homo sapiens_hsa004801.20242345
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16792675
58Pyrimidine metabolism_Homo sapiens_hsa002401.15949472
59Carbon metabolism_Homo sapiens_hsa012001.15632261
60Nitrogen metabolism_Homo sapiens_hsa009101.12296286
61beta-Alanine metabolism_Homo sapiens_hsa004101.10517939
62Biosynthesis of amino acids_Homo sapiens_hsa012301.09919942
63Vitamin B6 metabolism_Homo sapiens_hsa007501.05307206
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03870361
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99356188
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99114593
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98650718
68Legionellosis_Homo sapiens_hsa051340.97616061
69Base excision repair_Homo sapiens_hsa034100.95704580
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94755493
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92739431
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91621709
73Malaria_Homo sapiens_hsa051440.90885535
74Histidine metabolism_Homo sapiens_hsa003400.89158779
75RNA degradation_Homo sapiens_hsa030180.88186498
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87402617
77Galactose metabolism_Homo sapiens_hsa000520.85962458
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85347822
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.81633931
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80445966
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79632280
82Sulfur metabolism_Homo sapiens_hsa009200.77827126
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.77427208
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.76550708
85Antigen processing and presentation_Homo sapiens_hsa046120.76489141
86Fructose and mannose metabolism_Homo sapiens_hsa000510.76229532
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74131776
88Steroid biosynthesis_Homo sapiens_hsa001000.73816582
89Butanoate metabolism_Homo sapiens_hsa006500.73790590
90Other glycan degradation_Homo sapiens_hsa005110.73535810
91Tuberculosis_Homo sapiens_hsa051520.71549135
92Huntingtons disease_Homo sapiens_hsa050160.71187980
93Alzheimers disease_Homo sapiens_hsa050100.69616298
94Protein export_Homo sapiens_hsa030600.68918719
95Herpes simplex infection_Homo sapiens_hsa051680.68545584
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.67718344
97Linoleic acid metabolism_Homo sapiens_hsa005910.67710266
98Measles_Homo sapiens_hsa051620.67144376
99p53 signaling pathway_Homo sapiens_hsa041150.66005025
100Leishmaniasis_Homo sapiens_hsa051400.65608442
101Sulfur relay system_Homo sapiens_hsa041220.65502105
102Sphingolipid metabolism_Homo sapiens_hsa006000.64221709
103Phenylalanine metabolism_Homo sapiens_hsa003600.63051016
104Phagosome_Homo sapiens_hsa041450.62019047
105Homologous recombination_Homo sapiens_hsa034400.60062068
106Purine metabolism_Homo sapiens_hsa002300.59222598
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56184824
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56115192
109ABC transporters_Homo sapiens_hsa020100.54988962
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52575495
111Fat digestion and absorption_Homo sapiens_hsa049750.51885859
112Osteoclast differentiation_Homo sapiens_hsa043800.50976565
113Primary immunodeficiency_Homo sapiens_hsa053400.50528847
114Pertussis_Homo sapiens_hsa051330.50230831
115Cell cycle_Homo sapiens_hsa041100.49166824
116RNA transport_Homo sapiens_hsa030130.47761292
117Graft-versus-host disease_Homo sapiens_hsa053320.47466614
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46327006
119Shigellosis_Homo sapiens_hsa051310.45986490
120ECM-receptor interaction_Homo sapiens_hsa045120.45912154
121Renin-angiotensin system_Homo sapiens_hsa046140.45563934
122Metabolic pathways_Homo sapiens_hsa011000.45260263
123Allograft rejection_Homo sapiens_hsa053300.45146032
124Arginine and proline metabolism_Homo sapiens_hsa003300.45079554
125Arachidonic acid metabolism_Homo sapiens_hsa005900.44814863
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44607513
127Hematopoietic cell lineage_Homo sapiens_hsa046400.44152860
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44146205
129Fatty acid biosynthesis_Homo sapiens_hsa000610.43739178
130Lysosome_Homo sapiens_hsa041420.43525456
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42283081
132Nucleotide excision repair_Homo sapiens_hsa034200.42057643
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39630403
134Influenza A_Homo sapiens_hsa051640.39382411
135Ribosome_Homo sapiens_hsa030100.39330335

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