RNFT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.25649731
2synaptic vesicle maturation (GO:0016188)6.11373602
3locomotory exploration behavior (GO:0035641)5.86331116
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.75973195
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.68662777
6vocalization behavior (GO:0071625)5.65174379
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.38916938
8synaptic vesicle exocytosis (GO:0016079)5.26961720
9glutamate secretion (GO:0014047)5.09701280
10regulation of glutamate receptor signaling pathway (GO:1900449)5.03515900
11regulation of synaptic vesicle exocytosis (GO:2000300)5.00358792
12behavioral response to nicotine (GO:0035095)4.94513126
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.91508773
14protein localization to synapse (GO:0035418)4.86738835
15layer formation in cerebral cortex (GO:0021819)4.69992916
16neuron cell-cell adhesion (GO:0007158)4.64946783
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.60696119
18exploration behavior (GO:0035640)4.59656407
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.47441308
20neurotransmitter secretion (GO:0007269)4.47115264
21regulation of neuronal synaptic plasticity (GO:0048168)4.41976856
22regulation of synaptic vesicle transport (GO:1902803)4.40824840
23dendritic spine morphogenesis (GO:0060997)4.40635456
24regulation of synapse structural plasticity (GO:0051823)4.39659001
25neurotransmitter-gated ion channel clustering (GO:0072578)4.24823639
26synaptic transmission, glutamatergic (GO:0035249)4.18256688
27neuronal action potential propagation (GO:0019227)4.16666723
28glutamate receptor signaling pathway (GO:0007215)4.13785547
29gamma-aminobutyric acid transport (GO:0015812)4.11746403
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.04849770
31proline transport (GO:0015824)3.95480997
32neuron-neuron synaptic transmission (GO:0007270)3.94146716
33positive regulation of membrane potential (GO:0045838)3.86817715
34long-term memory (GO:0007616)3.84648379
35pyrimidine nucleobase catabolic process (GO:0006208)3.79365700
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.77038832
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75878070
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.75147405
39neuron recognition (GO:0008038)3.73746633
40cellular potassium ion homeostasis (GO:0030007)3.73606720
41positive regulation of synapse maturation (GO:0090129)3.68773858
42regulation of dendritic spine morphogenesis (GO:0061001)3.62714274
43neurotransmitter transport (GO:0006836)3.60674653
44regulation of postsynaptic membrane potential (GO:0060078)3.59914351
45auditory behavior (GO:0031223)3.59316447
46transmission of nerve impulse (GO:0019226)3.57530342
47neuromuscular process controlling balance (GO:0050885)3.55494349
48postsynaptic membrane organization (GO:0001941)3.54802330
49activation of protein kinase A activity (GO:0034199)3.50764899
50sodium ion export (GO:0071436)3.49847624
51axonal fasciculation (GO:0007413)3.49415046
52regulation of synaptic plasticity (GO:0048167)3.48697607
53dendrite morphogenesis (GO:0048813)3.47573113
54synaptic vesicle endocytosis (GO:0048488)3.46723844
55regulation of neurotransmitter secretion (GO:0046928)3.42375941
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.42126704
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.40073957
58response to auditory stimulus (GO:0010996)3.39378508
59response to pheromone (GO:0019236)3.35583060
60prepulse inhibition (GO:0060134)3.35299463
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.34612131
62cerebellar Purkinje cell differentiation (GO:0021702)3.34502275
63negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.34249503
64negative regulation of translation, ncRNA-mediated (GO:0040033)3.34249503
65regulation of translation, ncRNA-mediated (GO:0045974)3.34249503
66nonmotile primary cilium assembly (GO:0035058)3.34013553
67regulation of neurotransmitter levels (GO:0001505)3.29935949
68neuronal ion channel clustering (GO:0045161)3.29000243
69regulation of vesicle fusion (GO:0031338)3.27948393
70positive regulation of neurotransmitter transport (GO:0051590)3.23041109
71long-term synaptic potentiation (GO:0060291)3.22317622
72glycine transport (GO:0015816)3.22060367
73membrane hyperpolarization (GO:0060081)3.22010467
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.20605904
75gamma-aminobutyric acid signaling pathway (GO:0007214)3.20404462
76G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.20362764
77dendritic spine organization (GO:0097061)3.20149714
78positive regulation of neurotransmitter secretion (GO:0001956)3.18647467
79detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.18391199
80nucleobase catabolic process (GO:0046113)3.18114622
81regulation of neurotransmitter transport (GO:0051588)3.17989731
82cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17019809
83positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.15430049
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14602092
85cell communication by electrical coupling (GO:0010644)3.13152381
86cell migration in hindbrain (GO:0021535)3.13138719
87presynaptic membrane organization (GO:0097090)3.12734004
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.11143888
89protein polyglutamylation (GO:0018095)3.09633104
90negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09531010
91synapse assembly (GO:0007416)3.09198124
92vesicle transport along microtubule (GO:0047496)3.08869185
93membrane depolarization (GO:0051899)3.08509464
94neuromuscular process controlling posture (GO:0050884)3.07939875
95presynaptic membrane assembly (GO:0097105)3.07665271
96learning (GO:0007612)3.06148231
97positive regulation of dendritic spine development (GO:0060999)3.06146901
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.05507361
99negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05147991
100innervation (GO:0060384)3.04764432
101regulation of dendritic spine development (GO:0060998)3.03657906
102membrane depolarization during action potential (GO:0086010)3.03462419
103neural tube formation (GO:0001841)3.02962237
104behavioral fear response (GO:0001662)2.99548927
105behavioral defense response (GO:0002209)2.99548927
106positive regulation of dendritic spine morphogenesis (GO:0061003)2.99066573
107intraspecies interaction between organisms (GO:0051703)2.98849304
108social behavior (GO:0035176)2.98849304
109cerebellar granule cell differentiation (GO:0021707)2.98774841
110neuromuscular process (GO:0050905)2.96115664
111indolalkylamine metabolic process (GO:0006586)2.94162607
112positive regulation of synaptic transmission (GO:0050806)2.93940172
113L-fucose metabolic process (GO:0042354)2.93578336
114L-fucose catabolic process (GO:0042355)2.93578336
115fucose catabolic process (GO:0019317)2.93578336
116regulation of synaptic transmission (GO:0050804)2.92079043
117organelle transport along microtubule (GO:0072384)2.90859710
118behavioral response to ethanol (GO:0048149)2.89541682
119protein localization to cilium (GO:0061512)2.88304048
120epithelial cilium movement (GO:0003351)2.83327632
121negative regulation of telomere maintenance (GO:0032205)2.82949675
122regulation of cilium movement (GO:0003352)2.80074386
123water-soluble vitamin biosynthetic process (GO:0042364)2.77463583
124protein complex biogenesis (GO:0070271)2.77323814
125somite development (GO:0061053)2.75400513
126reflex (GO:0060004)2.74121482
127negative regulation of transcription regulatory region DNA binding (GO:2000678)2.73406426
128limb bud formation (GO:0060174)2.71790579
129tryptophan catabolic process (GO:0006569)2.70923681
130indole-containing compound catabolic process (GO:0042436)2.70923681
131indolalkylamine catabolic process (GO:0046218)2.70923681
132startle response (GO:0001964)2.69254371
133cellular ketone body metabolic process (GO:0046950)2.67851721
134cilium morphogenesis (GO:0060271)2.66585608
135axoneme assembly (GO:0035082)2.65696311
136detection of light stimulus involved in visual perception (GO:0050908)2.65153597
137detection of light stimulus involved in sensory perception (GO:0050962)2.65153597
138regulation of telomere maintenance (GO:0032204)2.64698277
139replication fork processing (GO:0031297)2.62225407
140mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.61966958
141mitochondrial respiratory chain complex I assembly (GO:0032981)2.61966958
142NADH dehydrogenase complex assembly (GO:0010257)2.61966958
143spinal cord development (GO:0021510)2.61545779
144cell proliferation in forebrain (GO:0021846)2.60909483
145kynurenine metabolic process (GO:0070189)2.58391545
146mitochondrial respiratory chain complex assembly (GO:0033108)2.56871835
147neuronal action potential (GO:0019228)2.54845696
148intraciliary transport (GO:0042073)2.54813272
149protein-cofactor linkage (GO:0018065)2.52956170
150negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52936808
151cilium organization (GO:0044782)2.51514899
152cornea development in camera-type eye (GO:0061303)2.49546235
153spinal cord motor neuron differentiation (GO:0021522)2.49411799
154cilium assembly (GO:0042384)2.47375498
155regulation of gene silencing by RNA (GO:0060966)2.46036582
156regulation of posttranscriptional gene silencing (GO:0060147)2.46036582
157regulation of gene silencing by miRNA (GO:0060964)2.46036582
158regulation of hippo signaling (GO:0035330)2.45349535
159cilium movement (GO:0003341)2.44676324
160retinal ganglion cell axon guidance (GO:0031290)2.44554742
161platelet dense granule organization (GO:0060155)2.43875469
162hindbrain development (GO:0030902)2.43505153
163primary amino compound metabolic process (GO:1901160)2.43354696
164DNA double-strand break processing (GO:0000729)2.43237843
165regulation of action potential (GO:0098900)2.43216371
166photoreceptor cell development (GO:0042461)2.43063635
167indole-containing compound metabolic process (GO:0042430)2.42632045
168positive regulation of oligodendrocyte differentiation (GO:0048714)2.41727488
169limb development (GO:0060173)2.41236634
170appendage development (GO:0048736)2.41236634
171kidney morphogenesis (GO:0060993)2.41033562
172ketone body metabolic process (GO:1902224)2.40025614
173mechanosensory behavior (GO:0007638)2.39963647
174neuron fate determination (GO:0048664)2.37942696
175piRNA metabolic process (GO:0034587)2.36887877
176neuromuscular synaptic transmission (GO:0007274)2.36440367
177microtubule depolymerization (GO:0007019)2.36018327
178serotonin metabolic process (GO:0042428)2.35430191
179nephron tubule morphogenesis (GO:0072078)2.32574793
180nephron epithelium morphogenesis (GO:0072088)2.32574793
181tachykinin receptor signaling pathway (GO:0007217)2.32289260

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.98544399
2GBX2_23144817_ChIP-Seq_PC3_Human3.32824666
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09291498
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07617556
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00372477
6VDR_22108803_ChIP-Seq_LS180_Human2.85689845
7REST_21632747_ChIP-Seq_MESCs_Mouse2.79920499
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74276738
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74276738
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.69826155
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65166011
12* DROSHA_22980978_ChIP-Seq_HELA_Human2.56758822
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.55015934
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54909424
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53291514
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52289978
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48546732
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45138951
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.31843314
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31756334
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.27435032
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.24834273
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.20403442
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.18363370
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14486689
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12418520
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10563089
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07906842
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07472927
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.06903408
31FUS_26573619_Chip-Seq_HEK293_Human2.06557589
32SALL1_21062744_ChIP-ChIP_HESCs_Human2.04026000
33POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03786876
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00326086
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99019756
36EWS_26573619_Chip-Seq_HEK293_Human1.94081875
37AR_21572438_ChIP-Seq_LNCaP_Human1.89670348
38* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85764062
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68089167
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61840175
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.61638007
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61279144
43ER_23166858_ChIP-Seq_MCF-7_Human1.55664509
44SMAD4_21799915_ChIP-Seq_A2780_Human1.53731587
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52448441
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48159153
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47059149
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.46414282
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44256408
50TAF15_26573619_Chip-Seq_HEK293_Human1.42806058
51IRF1_19129219_ChIP-ChIP_H3396_Human1.40539148
52ZNF274_21170338_ChIP-Seq_K562_Hela1.40535600
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39338522
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39320189
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.38591058
56BCAT_22108803_ChIP-Seq_LS180_Human1.38404911
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35527355
58CBP_20019798_ChIP-Seq_JUKART_Human1.35300807
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35300807
60TP53_22573176_ChIP-Seq_HFKS_Human1.33704091
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.31613666
62MYC_18940864_ChIP-ChIP_HL60_Human1.31394878
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29752884
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28210376
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27356841
66AR_19668381_ChIP-Seq_PC3_Human1.25252323
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24653509
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.24383984
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24291481
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23849278
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23116908
72EST1_17652178_ChIP-ChIP_JURKAT_Human1.21137310
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.20554560
74P300_19829295_ChIP-Seq_ESCs_Human1.20390495
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20361582
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.20343048
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20195943
78KDM2B_26808549_Chip-Seq_K562_Human1.20162081
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20137268
80STAT3_23295773_ChIP-Seq_U87_Human1.19250364
81TCF4_22108803_ChIP-Seq_LS180_Human1.19002083
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18711093
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.17454750
84AR_25329375_ChIP-Seq_VCAP_Human1.16030626
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15589545
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15321271
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14959509
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14490105
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.14259708
90KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11339658
91ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09689419
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09638085
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09217503
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08432492
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08228018
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08139353
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07438484
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06864660
99RNF2_27304074_Chip-Seq_NSC_Mouse1.05859296
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05668029
101NANOG_19829295_ChIP-Seq_ESCs_Human1.05559036
102SOX2_19829295_ChIP-Seq_ESCs_Human1.05559036
103ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05493966
104TCF4_23295773_ChIP-Seq_U87_Human1.05446640
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05216022
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.05122059
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04908731
108TP63_19390658_ChIP-ChIP_HaCaT_Human1.04448310
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.03843226
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.03506888
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03299470
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02873239
113IGF1R_20145208_ChIP-Seq_DFB_Human1.01868539
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01664746
115AHR_22903824_ChIP-Seq_MCF-7_Human1.01128602
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00557459
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00497176
118PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99701843
119NCOR_22424771_ChIP-Seq_293T_Human0.99589638
120NOTCH1_21737748_ChIP-Seq_TLL_Human0.99509102
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98670423
122FLI1_21867929_ChIP-Seq_TH2_Mouse0.98440538
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97755618
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.97708768
125NANOG_18555785_Chip-Seq_ESCs_Mouse0.97698562
126FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97312900
127FOXA1_25329375_ChIP-Seq_VCAP_Human0.97312900
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97111591
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95101202
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94769856
131RUNX2_22187159_ChIP-Seq_PCA_Human0.93199974
132* SMAD4_21741376_ChIP-Seq_HESCs_Human0.93145937
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.92826688
134ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92279722
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91924733
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89678590
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89678590
138TP53_16413492_ChIP-PET_HCT116_Human0.89188128
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.88582588
140ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88243944
141CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87811875
142* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87098170
143* TET1_21490601_ChIP-Seq_MESCs_Mouse0.86254460
144RXR_22108803_ChIP-Seq_LS180_Human0.85639674
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85157762
146TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84707803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.61266988
2MP0003880_abnormal_central_pattern4.55459887
3MP0003635_abnormal_synaptic_transmissio4.19368565
4MP0004270_analgesia3.83969713
5MP0009745_abnormal_behavioral_response3.39131176
6MP0002063_abnormal_learning/memory/cond3.35228807
7MP0005423_abnormal_somatic_nervous3.14059015
8MP0002064_seizures3.11835360
9MP0009046_muscle_twitch3.05013684
10MP0002822_catalepsy2.99922640
11MP0001968_abnormal_touch/_nociception2.88015032
12MP0006292_abnormal_olfactory_placode2.83696614
13MP0002572_abnormal_emotion/affect_behav2.76487489
14MP0002734_abnormal_mechanical_nocicepti2.70918532
15MP0001486_abnormal_startle_reflex2.66259065
16MP0002272_abnormal_nervous_system2.52034504
17MP0008877_abnormal_DNA_methylation2.27643512
18MP0002102_abnormal_ear_morphology2.14611269
19MP0009780_abnormal_chondrocyte_physiolo2.13776087
20MP0001501_abnormal_sleep_pattern2.13570190
21MP0002736_abnormal_nociception_after2.13070357
22MP0001440_abnormal_grooming_behavior2.11053252
23MP0002733_abnormal_thermal_nociception2.08265769
24MP0003136_yellow_coat_color2.04354550
25MP0002735_abnormal_chemical_nociception2.04138429
26MP0000778_abnormal_nervous_system2.00815781
27MP0001970_abnormal_pain_threshold1.96205167
28MP0004858_abnormal_nervous_system1.92849829
29MP0002938_white_spotting1.90104087
30MP0002067_abnormal_sensory_capabilities1.89946610
31MP0002184_abnormal_innervation1.86939027
32MP0008569_lethality_at_weaning1.86409275
33MP0002653_abnormal_ependyma_morphology1.84200906
34MP0004811_abnormal_neuron_physiology1.82784492
35MP0003329_amyloid_beta_deposits1.82440184
36MP0002557_abnormal_social/conspecific_i1.81744856
37MP0004924_abnormal_behavior1.76434420
38MP0005386_behavior/neurological_phenoty1.76434420
39MP0002909_abnormal_adrenal_gland1.70066365
40MP0005646_abnormal_pituitary_gland1.68886055
41MP0000955_abnormal_spinal_cord1.64880413
42MP0003195_calcinosis1.63641415
43MP0004885_abnormal_endolymph1.62963149
44MP0004133_heterotaxia1.61730022
45MP0003121_genomic_imprinting1.59335109
46MP0003879_abnormal_hair_cell1.54782056
47MP0002882_abnormal_neuron_morphology1.51733348
48MP0001984_abnormal_olfaction1.49922521
49MP0003787_abnormal_imprinting1.49610437
50MP0006276_abnormal_autonomic_nervous1.44678208
51MP0005645_abnormal_hypothalamus_physiol1.44091735
52MP0002066_abnormal_motor_capabilities/c1.43541736
53MP0008789_abnormal_olfactory_epithelium1.39855457
54MP0002234_abnormal_pharynx_morphology1.39249502
55MP0001529_abnormal_vocalization1.33607995
56MP0003119_abnormal_digestive_system1.32202235
57MP0003633_abnormal_nervous_system1.29756031
58MP0001502_abnormal_circadian_rhythm1.27348491
59MP0001986_abnormal_taste_sensitivity1.27007716
60MP0002837_dystrophic_cardiac_calcinosis1.26717236
61MP0004147_increased_porphyrin_level1.26567211
62MP0003890_abnormal_embryonic-extraembry1.24813656
63MP0005551_abnormal_eye_electrophysiolog1.24717487
64MP0004142_abnormal_muscle_tone1.22993804
65MP0003122_maternal_imprinting1.22120389
66MP0003878_abnormal_ear_physiology1.20619152
67MP0005377_hearing/vestibular/ear_phenot1.20619152
68MP0002152_abnormal_brain_morphology1.19338812
69MP0002751_abnormal_autonomic_nervous1.17528398
70MP0000026_abnormal_inner_ear1.16905694
71MP0003646_muscle_fatigue1.16456066
72MP0000566_synostosis1.15932839
73MP0001293_anophthalmia1.15301035
74MP0001905_abnormal_dopamine_level1.14733920
75MP0003631_nervous_system_phenotype1.11660146
76MP0003938_abnormal_ear_development1.09739231
77MP0002876_abnormal_thyroid_physiology1.08877164
78MP0000372_irregular_coat_pigmentation1.07578267
79MP0003937_abnormal_limbs/digits/tail_de1.06975667
80MP0000049_abnormal_middle_ear1.06691503
81MP0005195_abnormal_posterior_eye1.06534102
82MP0003283_abnormal_digestive_organ1.05919364
83MP0002229_neurodegeneration1.05213058
84MP0000427_abnormal_hair_cycle1.05157390
85MP0000569_abnormal_digit_pigmentation1.03860330
86MP0001188_hyperpigmentation1.00997958
87MP0008058_abnormal_DNA_repair1.00775302
88MP0002163_abnormal_gland_morphology0.98485440
89MP0003698_abnormal_male_reproductive0.97901049
90MP0005174_abnormal_tail_pigmentation0.96384417
91MP0001177_atelectasis0.95582714
92MP0002069_abnormal_eating/drinking_beha0.94241169
93MP0004742_abnormal_vestibular_system0.94171007
94MP0003634_abnormal_glial_cell0.93847599
95MP0000751_myopathy0.93175774
96MP0003011_delayed_dark_adaptation0.92909589
97MP0003718_maternal_effect0.91256802
98MP0002928_abnormal_bile_duct0.91145636
99MP0005084_abnormal_gallbladder_morpholo0.88304495
100MP0008872_abnormal_physiological_respon0.88268156
101MP0000631_abnormal_neuroendocrine_gland0.88077308
102MP0005499_abnormal_olfactory_system0.87518737
103MP0005394_taste/olfaction_phenotype0.87518737
104MP0010386_abnormal_urinary_bladder0.87404946
105MP0008961_abnormal_basal_metabolism0.87044214
106MP0008995_early_reproductive_senescence0.86158425
107MP0003690_abnormal_glial_cell0.86041353
108MP0003632_abnormal_nervous_system0.85336180
109MP0002752_abnormal_somatic_nervous0.84885991
110MP0004043_abnormal_pH_regulation0.84825547
111MP0002090_abnormal_vision0.84270231
112MP0002160_abnormal_reproductive_system0.83017148
113MP0004145_abnormal_muscle_electrophysio0.82476946
114MP0000920_abnormal_myelination0.82044720
115MP0001963_abnormal_hearing_physiology0.81449762
116MP0004085_abnormal_heartbeat0.80537592
117MP0008874_decreased_physiological_sensi0.80517028
118MP0005409_darkened_coat_color0.79336958
119MP0006072_abnormal_retinal_apoptosis0.77346454
120MP0000013_abnormal_adipose_tissue0.76660203
121MP0002638_abnormal_pupillary_reflex0.74525022
122MP0003075_altered_response_to0.74033805
123MP0005535_abnormal_body_temperature0.73882167
124MP0000604_amyloidosis0.72371796
125MP0004233_abnormal_muscle_weight0.69392890
126MP0003137_abnormal_impulse_conducting0.68821562
127MP0003861_abnormal_nervous_system0.67620819
128MP0001485_abnormal_pinna_reflex0.67258453
129MP0005623_abnormal_meninges_morphology0.62808459
130MP0005187_abnormal_penis_morphology0.62239558
131MP0005253_abnormal_eye_physiology0.62082884
132MP0003172_abnormal_lysosome_physiology0.61963116
133MP0001299_abnormal_eye_distance/0.60735013
134MP0005167_abnormal_blood-brain_barrier0.59676253
135MP0001943_abnormal_respiration0.56404118
136MP0001664_abnormal_digestion0.56315812
137MP0010769_abnormal_survival0.55319305
138MP0004484_altered_response_of0.54860790
139MP0004215_abnormal_myocardial_fiber0.54097591
140MP0010770_preweaning_lethality0.53431142
141MP0002082_postnatal_lethality0.53431142

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.92734330
2Myokymia (HP:0002411)6.86602112
3Focal seizures (HP:0007359)5.47398290
4Visual hallucinations (HP:0002367)5.13980258
5Epileptic encephalopathy (HP:0200134)4.66653434
6Atonic seizures (HP:0010819)4.15176837
7Febrile seizures (HP:0002373)4.14491679
8Progressive cerebellar ataxia (HP:0002073)4.11475929
9Pancreatic cysts (HP:0001737)3.90202583
10Supranuclear gaze palsy (HP:0000605)3.84310703
11Absence seizures (HP:0002121)3.82293390
12Action tremor (HP:0002345)3.80554884
13Ankle clonus (HP:0011448)3.70905157
14Generalized tonic-clonic seizures (HP:0002069)3.62552181
15Pancreatic fibrosis (HP:0100732)3.57986466
16True hermaphroditism (HP:0010459)3.53313718
17Abnormality of midbrain morphology (HP:0002418)3.51227930
18Molar tooth sign on MRI (HP:0002419)3.51227930
19Broad-based gait (HP:0002136)3.50361218
20Dialeptic seizures (HP:0011146)3.45860186
21Nephronophthisis (HP:0000090)3.44586287
22Poor eye contact (HP:0000817)3.40527005
23Mutism (HP:0002300)3.35291761
24Impaired vibration sensation in the lower limbs (HP:0002166)3.29521932
25Depression (HP:0000716)3.24168344
26Urinary bladder sphincter dysfunction (HP:0002839)3.19564482
27Congenital stationary night blindness (HP:0007642)3.14551764
28Gaze-evoked nystagmus (HP:0000640)3.13291212
29Papilledema (HP:0001085)3.12897320
30Dysdiadochokinesis (HP:0002075)3.11573736
31Abnormal social behavior (HP:0012433)3.09048453
32Impaired social interactions (HP:0000735)3.09048453
33Type II lissencephaly (HP:0007260)2.98267850
34Abnormality of the renal medulla (HP:0100957)2.94504403
35Pendular nystagmus (HP:0012043)2.93429711
36Medial flaring of the eyebrow (HP:0010747)2.92789397
37Abnormal eating behavior (HP:0100738)2.91610373
38Dysmetria (HP:0001310)2.90754282
39Anxiety (HP:0000739)2.88810397
40Hyperventilation (HP:0002883)2.87554520
41Postural instability (HP:0002172)2.86850442
42Truncal ataxia (HP:0002078)2.85727773
43Genetic anticipation (HP:0003743)2.83491623
44Hemiparesis (HP:0001269)2.79097577
45Abnormality of the labia minora (HP:0012880)2.78249015
46Abnormality of the lower motor neuron (HP:0002366)2.77549727
47Urinary urgency (HP:0000012)2.75762072
48Amblyopia (HP:0000646)2.75711285
49Neurofibrillary tangles (HP:0002185)2.75337589
50Torticollis (HP:0000473)2.74964507
51Excessive salivation (HP:0003781)2.72909739
52Drooling (HP:0002307)2.72909739
53Spastic gait (HP:0002064)2.71212710
54Cerebral inclusion bodies (HP:0100314)2.64349753
55Retinal dysplasia (HP:0007973)2.61601926
56Impaired smooth pursuit (HP:0007772)2.60754528
57Abnormality of binocular vision (HP:0011514)2.59831732
58Diplopia (HP:0000651)2.59831732
59Abnormality of the corticospinal tract (HP:0002492)2.59156010
60Gait imbalance (HP:0002141)2.58085281
61Sclerocornea (HP:0000647)2.58057978
62Cystic liver disease (HP:0006706)2.52226817
63Chronic hepatic failure (HP:0100626)2.51582648
64Abnormality of the renal cortex (HP:0011035)2.51070847
65Focal dystonia (HP:0004373)2.50725403
66Megalencephaly (HP:0001355)2.50693527
67Tubular atrophy (HP:0000092)2.50682717
68Stereotypic behavior (HP:0000733)2.50401482
69Limb dystonia (HP:0002451)2.50147236
70Lissencephaly (HP:0001339)2.48754659
71Intention tremor (HP:0002080)2.47337051
72Insidious onset (HP:0003587)2.45239872
73Termporal pattern (HP:0011008)2.45239872
74Progressive inability to walk (HP:0002505)2.44056513
75Bradykinesia (HP:0002067)2.44022434
76Amyotrophic lateral sclerosis (HP:0007354)2.38506798
77Scanning speech (HP:0002168)2.37176277
78Optic nerve hypoplasia (HP:0000609)2.37125752
79Hemiplegia (HP:0002301)2.35563913
80Epileptiform EEG discharges (HP:0011182)2.35510280
81Congenital primary aphakia (HP:0007707)2.34328821
82Abolished electroretinogram (ERG) (HP:0000550)2.34233868
83Insomnia (HP:0100785)2.33848252
84Lower limb muscle weakness (HP:0007340)2.32878367
85EEG with generalized epileptiform discharges (HP:0011198)2.31762790
86Fetal akinesia sequence (HP:0001989)2.30369145
87Attenuation of retinal blood vessels (HP:0007843)2.30179215
88Abnormality of ocular smooth pursuit (HP:0000617)2.29555420
89Cerebellar dysplasia (HP:0007033)2.28089061
90Septo-optic dysplasia (HP:0100842)2.27673598
91Polyphagia (HP:0002591)2.26404328
92Craniofacial dystonia (HP:0012179)2.26029443
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.24798511
94Anencephaly (HP:0002323)2.22776131
95Genital tract atresia (HP:0001827)2.21737188
96Absent speech (HP:0001344)2.21389703
97Hypsarrhythmia (HP:0002521)2.21238765
98Oligodactyly (hands) (HP:0001180)2.19887868
99Nephrogenic diabetes insipidus (HP:0009806)2.18133053
100Pointed chin (HP:0000307)2.18103889
101Impaired vibratory sensation (HP:0002495)2.17967123
102Vaginal atresia (HP:0000148)2.17214200
103Annular pancreas (HP:0001734)2.16013891
104Polydipsia (HP:0001959)2.14104258
105Abnormal drinking behavior (HP:0030082)2.14104258
106Inappropriate behavior (HP:0000719)2.09635559
107Acute necrotizing encephalopathy (HP:0006965)2.08565097
108Patellar aplasia (HP:0006443)2.08454215
109Ventricular fibrillation (HP:0001663)2.04770503
110Status epilepticus (HP:0002133)2.04016092
111Aplasia/Hypoplasia of the tongue (HP:0010295)2.03793302
112Akinesia (HP:0002304)2.00724926
113Bony spicule pigmentary retinopathy (HP:0007737)2.00647627
114Generalized myoclonic seizures (HP:0002123)2.00156740
115Aplasia/Hypoplasia of the patella (HP:0006498)1.99301253
116Obstructive sleep apnea (HP:0002870)1.98585688
117Inability to walk (HP:0002540)1.97261545
118Clonus (HP:0002169)1.97216038
119Dysmetric saccades (HP:0000641)1.96953376
120Agitation (HP:0000713)1.95713690
121Abnormal rod and cone electroretinograms (HP:0008323)1.95303350
122Pheochromocytoma (HP:0002666)1.95244183
123Aplasia/Hypoplasia of the tibia (HP:0005772)1.92568197
124Neuronal loss in central nervous system (HP:0002529)1.91917874
125Protruding tongue (HP:0010808)1.91466958
126Intestinal atresia (HP:0011100)1.91286826
127Colon cancer (HP:0003003)1.91123457
128Ectopic kidney (HP:0000086)1.89719728
129Aplasia/Hypoplasia of the uvula (HP:0010293)1.89197692
130Apathy (HP:0000741)1.88779445
131Anophthalmia (HP:0000528)1.88118356
132Lower limb amyotrophy (HP:0007210)1.87527303
133Pachygyria (HP:0001302)1.84883150
134Blue irides (HP:0000635)1.84184231
135Decreased central vision (HP:0007663)1.83869996
136Acute encephalopathy (HP:0006846)1.83631072
137Progressive macrocephaly (HP:0004481)1.83485014
138Poor coordination (HP:0002370)1.83123303
139Incomplete penetrance (HP:0003829)1.83060244
140Increased corneal curvature (HP:0100692)1.82938994
141Keratoconus (HP:0000563)1.82938994
142Male pseudohermaphroditism (HP:0000037)1.82564273
143Postaxial foot polydactyly (HP:0001830)1.82197361
144Resting tremor (HP:0002322)1.81131109
145Gait ataxia (HP:0002066)1.80997376
146Abnormality of salivation (HP:0100755)1.80871973
147Preaxial hand polydactyly (HP:0001177)1.79830778
148Chorioretinal atrophy (HP:0000533)1.79694948
149Mitochondrial inheritance (HP:0001427)1.79189554
150Abnormal EKG (HP:0003115)1.78920986
151Congenital hepatic fibrosis (HP:0002612)1.78573242
152Abnormal mitochondria in muscle tissue (HP:0008316)1.78192875
153Dandy-Walker malformation (HP:0001305)1.78098331
154Aplasia involving bones of the upper limbs (HP:0009823)1.77488574
155Aplasia of the phalanges of the hand (HP:0009802)1.77488574
156Aplasia involving bones of the extremities (HP:0009825)1.77488574
157Absent/shortened dynein arms (HP:0200106)1.74962805
158Dynein arm defect of respiratory motile cilia (HP:0012255)1.74962805
159Ankyloglossia (HP:0010296)1.74155054
160Postaxial hand polydactyly (HP:0001162)1.73618585
161Increased CSF lactate (HP:0002490)1.72378490
162Aqueductal stenosis (HP:0002410)1.72000709
163Polyuria (HP:0000103)1.71116893
164Meckel diverticulum (HP:0002245)1.70943544
165Specific learning disability (HP:0001328)1.70890503
166Optic disc pallor (HP:0000543)1.70376187
167Abnormality of alanine metabolism (HP:0010916)1.70366149
168Hyperalaninemia (HP:0003348)1.70366149
169Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70366149
170Central scotoma (HP:0000603)1.70365672
171Abnormality of the ileum (HP:0001549)1.70345568
172Hypothermia (HP:0002045)1.69818475
173Rapidly progressive (HP:0003678)1.69470480
174Lower limb asymmetry (HP:0100559)1.69371470
175Concave nail (HP:0001598)1.68500227
176Hypoplasia of the pons (HP:0012110)1.68239130
177Small hand (HP:0200055)1.67859102
178Methylmalonic acidemia (HP:0002912)1.67465871
179Rib fusion (HP:0000902)1.66125405
180Abnormal respiratory epithelium morphology (HP:0012253)1.63409156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.71589928
2EPHA44.20425819
3NTRK34.17557828
4MAP3K94.07983096
5MARK14.00261273
6MAP3K42.95027767
7MINK12.77061029
8BMPR1B2.48489129
9DAPK22.45202402
10ADRBK22.42632764
11MAP2K72.41664180
12PAK62.37239543
13NTRK22.36243008
14INSRR2.21618637
15ZAK2.20253810
16MAP4K22.19929577
17PRKD32.16881290
18KSR22.11166851
19GRK11.94233796
20MKNK21.91432422
21NTRK11.88896993
22WNK41.87873736
23NUAK11.86512925
24TLK11.85084287
25CAMKK11.84690632
26DYRK21.77671950
27MAP2K41.76720119
28KSR11.76678916
29SIK21.68646651
30TNIK1.59339333
31CDK51.58198679
32STK391.55723839
33MAP3K121.51475583
34MAPK131.49313516
35PRPF4B1.44950706
36RIPK41.43397982
37ACVR1B1.42971162
38CASK1.42021021
39DAPK11.39785579
40PNCK1.38321385
41LATS21.36758192
42STK381.34751817
43PLK21.32119482
44TRIM281.29815289
45TYRO31.29195179
46PHKG11.26341937
47PHKG21.26341937
48UHMK11.22399958
49PLK41.21017295
50GRK51.20565782
51MAP3K21.19409349
52PRKCG1.19364418
53ARAF1.15863092
54TAOK11.10756806
55MKNK11.06087838
56CDK191.03454851
57FES1.02768454
58CDC70.99762703
59BCR0.97157738
60STK110.95955566
61MAP3K130.93551276
62PLK30.92488989
63VRK10.92071340
64PRKCH0.91994972
65CDK180.91817111
66CDK150.90915354
67RET0.89568371
68BRSK20.89223353
69SGK2230.89150192
70SGK4940.89150192
71CAMK2A0.87579838
72CDK140.87336837
73CSNK1G10.87206608
74CAMK10.87100083
75CAMKK20.86459422
76ADRBK10.86047884
77WEE10.84260071
78TAOK30.84029298
79ALK0.83913448
80NEK20.82818494
81CSNK1G20.81634204
82MARK20.79251809
83CDK11A0.78775069
84BUB10.78518333
85RAF10.75964973
86PAK30.74055624
87DYRK1A0.73372777
88CSNK1G30.73255408
89PLK10.72158396
90SGK20.71586165
91MUSK0.70982282
92SGK30.69834365
93SGK10.69481358
94NME10.68305375
95PINK10.66246653
96CAMK2B0.65876718
97LMTK20.65849461
98CAMK1G0.63328518
99TIE10.60385853
100OXSR10.60326968
101PRKCZ0.60031412
102TGFBR10.59726614
103CSNK1A1L0.58743682
104RIPK10.58274935
105VRK20.58043908
106MAPK150.57554462
107BMPR20.57394733
108EPHB20.55706633
109DYRK30.55167762
110TAF10.53953889
111PDK10.53831530
112STK38L0.53535466
113CDC42BPA0.53431665
114PRKCI0.52005077
115CSNK1A10.51151203
116ERBB30.50774455
117CAMK1D0.50496960
118RPS6KA30.50390702
119PIK3CA0.50194382
120CHEK20.49825220
121WNK10.49780877
122MAP2K60.49535901
123PDPK10.49326617
124ATR0.49068558
125FYN0.48863009
126MAP3K60.48554641
127PRKCE0.47718289
128PTK2B0.47366419
129TNK20.46876906
130ERBB20.46104856
131MAP3K10.45602560
132MAPK100.45582163
133PRKACA0.44538983
134PRKAA10.42910152
135NEK60.42731280
136TSSK60.42631178
137RPS6KA50.41938482
138STK30.41402753
139SCYL20.41290756
140PKN10.40960952
141CDK30.39285340
142RPS6KA20.38861723
143CAMK2D0.38513908
144CSNK1E0.38510673
145CAMK40.38469139
146ICK0.38270036
147PRKG10.37835034
148PASK0.36057221
149ATM0.35819296
150FGR0.35477592
151BRSK10.33818214
152WNK30.33624484
153CAMK2G0.33480539
154PRKCB0.33026515
155MAP2K10.32914610
156DDR20.32697118
157FGFR20.32511735
158NEK10.31642174
159DMPK0.31284432

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.53319641
2Synaptic vesicle cycle_Homo sapiens_hsa047213.25496328
3Olfactory transduction_Homo sapiens_hsa047402.80617022
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.79194239
5GABAergic synapse_Homo sapiens_hsa047272.72290114
6Circadian entrainment_Homo sapiens_hsa047132.68728347
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59387968
8Glutamatergic synapse_Homo sapiens_hsa047242.59017267
9Long-term potentiation_Homo sapiens_hsa047202.53406488
10Morphine addiction_Homo sapiens_hsa050322.52608686
11Oxidative phosphorylation_Homo sapiens_hsa001902.46331822
12Butanoate metabolism_Homo sapiens_hsa006502.33643078
13Amphetamine addiction_Homo sapiens_hsa050312.33359697
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18283594
15Dopaminergic synapse_Homo sapiens_hsa047282.17598677
16Salivary secretion_Homo sapiens_hsa049702.10299722
17Cholinergic synapse_Homo sapiens_hsa047251.99946981
18Parkinsons disease_Homo sapiens_hsa050121.99597253
19Homologous recombination_Homo sapiens_hsa034401.99002059
20Insulin secretion_Homo sapiens_hsa049111.96597441
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.93717222
22Fanconi anemia pathway_Homo sapiens_hsa034601.85813809
23Gastric acid secretion_Homo sapiens_hsa049711.85054673
24RNA polymerase_Homo sapiens_hsa030201.84953363
25Protein export_Homo sapiens_hsa030601.82769325
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81391100
27Linoleic acid metabolism_Homo sapiens_hsa005911.80005264
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79890731
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79134239
30Selenocompound metabolism_Homo sapiens_hsa004501.72742023
31Cocaine addiction_Homo sapiens_hsa050301.72479489
32Long-term depression_Homo sapiens_hsa047301.69493926
33Basal transcription factors_Homo sapiens_hsa030221.68607788
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67468239
35Taste transduction_Homo sapiens_hsa047421.67120322
36Renin secretion_Homo sapiens_hsa049241.66899011
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.66848287
38Oxytocin signaling pathway_Homo sapiens_hsa049211.64395862
39Serotonergic synapse_Homo sapiens_hsa047261.64382728
40Huntingtons disease_Homo sapiens_hsa050161.51400850
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51041791
42Calcium signaling pathway_Homo sapiens_hsa040201.50720527
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49319591
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47712420
45GnRH signaling pathway_Homo sapiens_hsa049121.45650493
46Tryptophan metabolism_Homo sapiens_hsa003801.43894817
47Gap junction_Homo sapiens_hsa045401.42757825
48Phototransduction_Homo sapiens_hsa047441.35848851
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35657782
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32535715
51Alzheimers disease_Homo sapiens_hsa050101.32209457
52Axon guidance_Homo sapiens_hsa043601.29855640
53RNA degradation_Homo sapiens_hsa030181.28030166
54Ether lipid metabolism_Homo sapiens_hsa005651.26926961
55cAMP signaling pathway_Homo sapiens_hsa040241.25852808
56Type II diabetes mellitus_Homo sapiens_hsa049301.25130595
57Propanoate metabolism_Homo sapiens_hsa006401.23410669
58Collecting duct acid secretion_Homo sapiens_hsa049661.22606197
59Estrogen signaling pathway_Homo sapiens_hsa049151.18117030
60Glioma_Homo sapiens_hsa052141.17563447
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16069651
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14654608
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11815965
64ErbB signaling pathway_Homo sapiens_hsa040121.10028152
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07854021
66Steroid biosynthesis_Homo sapiens_hsa001001.07706721
67Melanogenesis_Homo sapiens_hsa049161.07146434
68Caffeine metabolism_Homo sapiens_hsa002321.05157874
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03125459
70Non-homologous end-joining_Homo sapiens_hsa034501.00035028
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97901304
72Nitrogen metabolism_Homo sapiens_hsa009100.97411132
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95410337
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.93659065
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.89586468
76Dorso-ventral axis formation_Homo sapiens_hsa043200.88880711
77Oocyte meiosis_Homo sapiens_hsa041140.88705029
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.88695957
79Cardiac muscle contraction_Homo sapiens_hsa042600.88023999
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86857415
81Basal cell carcinoma_Homo sapiens_hsa052170.85412903
82Vibrio cholerae infection_Homo sapiens_hsa051100.80736788
83Peroxisome_Homo sapiens_hsa041460.80648281
84Hedgehog signaling pathway_Homo sapiens_hsa043400.78843698
85Pancreatic secretion_Homo sapiens_hsa049720.77628027
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77103309
87One carbon pool by folate_Homo sapiens_hsa006700.76772941
88Dilated cardiomyopathy_Homo sapiens_hsa054140.75794544
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74460426
90Choline metabolism in cancer_Homo sapiens_hsa052310.73890060
91Thyroid hormone synthesis_Homo sapiens_hsa049180.73767094
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73528211
93MAPK signaling pathway_Homo sapiens_hsa040100.73251918
94Retinol metabolism_Homo sapiens_hsa008300.73236156
95Purine metabolism_Homo sapiens_hsa002300.73060088
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72589558
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.71924308
98Regulation of autophagy_Homo sapiens_hsa041400.70627917
99ABC transporters_Homo sapiens_hsa020100.70344744
100Chemical carcinogenesis_Homo sapiens_hsa052040.69152289
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68480494
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.68343703
103Mismatch repair_Homo sapiens_hsa034300.66309733
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66149160
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65455108
106beta-Alanine metabolism_Homo sapiens_hsa004100.64657953
107VEGF signaling pathway_Homo sapiens_hsa043700.64043058
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63981362
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63927741
110Ribosome_Homo sapiens_hsa030100.63485676
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62320909
112Ras signaling pathway_Homo sapiens_hsa040140.61147572
113mTOR signaling pathway_Homo sapiens_hsa041500.60040870
114Endometrial cancer_Homo sapiens_hsa052130.59539754
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59247886
116Alcoholism_Homo sapiens_hsa050340.58727717
117Rap1 signaling pathway_Homo sapiens_hsa040150.57754588
118Sulfur relay system_Homo sapiens_hsa041220.57688056
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.57050792
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56438945
121Metabolic pathways_Homo sapiens_hsa011000.56351055
122Type I diabetes mellitus_Homo sapiens_hsa049400.56321960
123Renal cell carcinoma_Homo sapiens_hsa052110.52593869
124Glucagon signaling pathway_Homo sapiens_hsa049220.52579247
125RNA transport_Homo sapiens_hsa030130.51593747
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51340432
127Endocytosis_Homo sapiens_hsa041440.51245978
128Non-small cell lung cancer_Homo sapiens_hsa052230.50836219
129Wnt signaling pathway_Homo sapiens_hsa043100.50651089
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.50626000
131Hippo signaling pathway_Homo sapiens_hsa043900.49760368
132Lysine degradation_Homo sapiens_hsa003100.49704028
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48443377
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48219109
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48034789
136Arachidonic acid metabolism_Homo sapiens_hsa005900.47835867
137Fat digestion and absorption_Homo sapiens_hsa049750.47768217
138Inositol phosphate metabolism_Homo sapiens_hsa005620.47523215
139Glycerolipid metabolism_Homo sapiens_hsa005610.46702565
140Pyrimidine metabolism_Homo sapiens_hsa002400.46230775
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46099097
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46053348
143Bile secretion_Homo sapiens_hsa049760.44662680
144Prion diseases_Homo sapiens_hsa050200.44539009
145Nucleotide excision repair_Homo sapiens_hsa034200.44363097
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44117226
147Insulin signaling pathway_Homo sapiens_hsa049100.43926556
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43766373
149Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42466570
150Circadian rhythm_Homo sapiens_hsa047100.41092426
151Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41090675
152Ovarian steroidogenesis_Homo sapiens_hsa049130.40171682
153Colorectal cancer_Homo sapiens_hsa052100.38585179
154Chemokine signaling pathway_Homo sapiens_hsa040620.38099645
155Proteasome_Homo sapiens_hsa030500.36330527
156Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36230021
157Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33931263
158Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32991488
159Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32049072
160Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30789475
161Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29806898
162SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28794776
163African trypanosomiasis_Homo sapiens_hsa051430.28378094
164Prolactin signaling pathway_Homo sapiens_hsa049170.24630487

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