RNH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64531024
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.49374200
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.49374200
4neutrophil activation involved in immune response (GO:0002283)4.24434423
5antigen processing and presentation of endogenous antigen (GO:0019883)4.19964460
6protein localization to endosome (GO:0036010)4.09183385
7positive regulation by symbiont of host defense response (GO:0052509)3.92549511
8modulation by symbiont of host defense response (GO:0052031)3.92549511
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.92549511
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.92549511
11positive regulation by organism of defense response of other organism involved in symbiotic interact3.92549511
12modulation by symbiont of host immune response (GO:0052553)3.92549511
13regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.74479092
14regulation of interferon-beta biosynthetic process (GO:0045357)3.65519027
15mannose metabolic process (GO:0006013)3.64051534
16virion attachment to host cell (GO:0019062)3.58688196
17adhesion of symbiont to host cell (GO:0044650)3.58688196
18positive regulation of interferon-alpha production (GO:0032727)3.49968406
19adhesion of symbiont to host (GO:0044406)3.35478488
20respiratory burst (GO:0045730)3.34676288
21regulation of interferon-alpha production (GO:0032647)3.31271942
22negative regulation of erythrocyte differentiation (GO:0045647)3.28987218
23amino sugar catabolic process (GO:0046348)3.26986309
24immunoglobulin mediated immune response (GO:0016064)3.26779898
25fibril organization (GO:0097435)3.23507109
26extracellular fibril organization (GO:0043206)3.23070709
27response to peptidoglycan (GO:0032494)3.13895236
28stress fiber assembly (GO:0043149)3.07031379
29COPI coating of Golgi vesicle (GO:0048205)3.05469016
30Golgi transport vesicle coating (GO:0048200)3.05469016
31positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.04704022
32positive regulation of antigen processing and presentation (GO:0002579)3.04105801
33macrophage activation involved in immune response (GO:0002281)3.03891950
34negative regulation of nitric oxide biosynthetic process (GO:0045019)3.01223396
35glycosphingolipid catabolic process (GO:0046479)2.99758277
36low-density lipoprotein particle clearance (GO:0034383)2.99520139
37skin morphogenesis (GO:0043589)2.97777761
38pinocytosis (GO:0006907)2.91263407
39hyaluronan catabolic process (GO:0030214)2.90597777
40protein maturation by protein folding (GO:0022417)2.89308470
41UV protection (GO:0009650)2.85233463
42Arp2/3 complex-mediated actin nucleation (GO:0034314)2.84496625
43response to interferon-beta (GO:0035456)2.84468581
44production of molecular mediator involved in inflammatory response (GO:0002532)2.79218024
45regulation of extracellular matrix disassembly (GO:0010715)2.78629676
46regulation of antigen processing and presentation (GO:0002577)2.75719870
47mitochondrial calcium ion transport (GO:0006851)2.75374893
48signal peptide processing (GO:0006465)2.73684244
49regulation of early endosome to late endosome transport (GO:2000641)2.71042427
50aldehyde catabolic process (GO:0046185)2.69484659
51cellular response to type I interferon (GO:0071357)2.69107847
52type I interferon signaling pathway (GO:0060337)2.69107847
53hydrogen peroxide biosynthetic process (GO:0050665)2.68535916
54glycolipid catabolic process (GO:0019377)2.68074138
55apoptotic cell clearance (GO:0043277)2.68000613
56response to type I interferon (GO:0034340)2.67972560
57cellular response to arsenic-containing substance (GO:0071243)2.67894927
58antigen processing and presentation via MHC class Ib (GO:0002475)2.66587253
59membrane raft organization (GO:0031579)2.65187621
60regulation of cholesterol storage (GO:0010885)2.64416695
61type B pancreatic cell proliferation (GO:0044342)2.63572579
62negative regulation of interleukin-12 production (GO:0032695)2.63371386
63response to interferon-alpha (GO:0035455)2.62286813
64amyloid precursor protein catabolic process (GO:0042987)2.62161837
65maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60979563
66positive regulation of receptor recycling (GO:0001921)2.60555650
67regulation of leukocyte degranulation (GO:0043300)2.57891845
68granulocyte activation (GO:0036230)2.57263459
69myeloid cell homeostasis (GO:0002262)2.56267370
70mature B cell differentiation involved in immune response (GO:0002313)2.55309585
71regulation of mast cell degranulation (GO:0043304)2.52592219
72response to progesterone (GO:0032570)2.51782040
73reactive oxygen species biosynthetic process (GO:1903409)2.51375959
74lipopolysaccharide-mediated signaling pathway (GO:0031663)2.51087543
75response to muramyl dipeptide (GO:0032495)2.50870058
76positive regulation of interferon-beta production (GO:0032728)2.50728890
77regulation of B cell receptor signaling pathway (GO:0050855)2.48427676
78glial cell migration (GO:0008347)2.47779251
79myeloid cell activation involved in immune response (GO:0002275)2.47472253
80protein retention in ER lumen (GO:0006621)2.47332182
81regulation of mononuclear cell migration (GO:0071675)2.47030432
82detection of other organism (GO:0098543)2.46851187
83response to host immune response (GO:0052572)2.46335536
84response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.46335536
85detection of bacterium (GO:0016045)2.46316468
86endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.46168570
87positive regulation of extracellular matrix organization (GO:1903055)2.46090338
88neutrophil activation (GO:0042119)2.45747218
89natural killer cell mediated immunity (GO:0002228)2.45192439
90natural killer cell mediated cytotoxicity (GO:0042267)2.45192439
91positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.44390551
92response to laminar fluid shear stress (GO:0034616)2.41682426
93response to thyroid hormone (GO:0097066)2.40961062
94regulation of necrotic cell death (GO:0010939)2.40607895
95positive regulation of chemokine biosynthetic process (GO:0045080)2.40210993
96cellular response to interferon-beta (GO:0035458)2.38905588
97retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.37959450
98keratan sulfate catabolic process (GO:0042340)2.37907355
99peptidyl-glutamic acid carboxylation (GO:0017187)2.36013529
100protein carboxylation (GO:0018214)2.36013529
101GDP-mannose metabolic process (GO:0019673)2.35629344
102B cell mediated immunity (GO:0019724)2.34631244
103decidualization (GO:0046697)2.33848853
104regulation of superoxide anion generation (GO:0032928)2.33379229
105positive regulation of Cdc42 GTPase activity (GO:0043089)2.33329492
106regulation of myeloid leukocyte mediated immunity (GO:0002886)2.32790531
107pentose-phosphate shunt (GO:0006098)2.32506650
108regulation of interleukin-8 biosynthetic process (GO:0045414)2.32433657
109cellular response to thyroid hormone stimulus (GO:0097067)2.31571737
110basement membrane organization (GO:0071711)2.31248211
111detection of molecule of bacterial origin (GO:0032490)2.31053528
112oligosaccharide catabolic process (GO:0009313)2.30745552
113positive regulation of natural killer cell differentiation (GO:0032825)2.30588701
114adenosine receptor signaling pathway (GO:0001973)2.29720021
115positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.29497394
116regulation of monocyte chemotaxis (GO:0090025)2.29051259
117myeloid dendritic cell differentiation (GO:0043011)2.28914114
118interferon-gamma-mediated signaling pathway (GO:0060333)2.28521243
119regulation of chemokine biosynthetic process (GO:0045073)2.28426932
120hypotonic response (GO:0006971)2.27815466
121positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.27760016
122modulation by symbiont of host cellular process (GO:0044068)2.26154417
123glucose catabolic process (GO:0006007)2.26099407
124negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.25760750
125cortical actin cytoskeleton organization (GO:0030866)2.25666938
126wound healing, spreading of epidermal cells (GO:0035313)2.25125044
127negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.25050809
128NADPH regeneration (GO:0006740)2.24880427
129ceramide catabolic process (GO:0046514)2.24513103
130negative regulation of cell size (GO:0045792)2.24292228
131positive regulation of gamma-delta T cell activation (GO:0046645)2.23895995
132macrophage activation (GO:0042116)2.23892643
133positive regulation of leukocyte degranulation (GO:0043302)2.23776964
134regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.22760531
135regulation of type I interferon-mediated signaling pathway (GO:0060338)2.22422089
136negative regulation of myeloid cell apoptotic process (GO:0033033)2.22100432
137regulation of vitamin D biosynthetic process (GO:0060556)2.21567301
138regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.21255866
139negative regulation of smooth muscle cell migration (GO:0014912)2.20892927
140regulation of mast cell activation involved in immune response (GO:0033006)2.20853900
141peptide catabolic process (GO:0043171)2.20488804
142negative regulation of tumor necrosis factor production (GO:0032720)2.20334542
143negative regulation of lipid storage (GO:0010888)2.19776895
144negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.19344808
145negative regulation of mast cell activation (GO:0033004)2.18777804
146primary alcohol catabolic process (GO:0034310)2.17989563
147barbed-end actin filament capping (GO:0051016)2.17462908
148response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.17154938
149response to host (GO:0075136)2.17154938
150response to host defenses (GO:0052200)2.17154938
151positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.16175537
152regulation of podosome assembly (GO:0071801)2.15562771
153positive regulation of B cell differentiation (GO:0045579)2.13260150
154actin nucleation (GO:0045010)2.12925117
155positive regulation of monocyte chemotaxis (GO:0090026)2.12869097
156positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.12632465
157antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.11810714
158cellular response to zinc ion (GO:0071294)2.11543600
159leukotriene metabolic process (GO:0006691)2.11299276
160positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.10036426
161regulation of membrane protein ectodomain proteolysis (GO:0051043)2.09718832
162NIK/NF-kappaB signaling (GO:0038061)2.09348406

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.85475575
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.27562842
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.05286296
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.95642388
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.83790722
6* IRF8_27001747_Chip-Seq_BMDM_Mouse2.57604579
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54690683
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.54618057
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54030860
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.43485183
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43132502
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.42798699
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36757696
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.30078733
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.26227226
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23628344
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18940401
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16385266
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.15302826
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.13479262
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.04889180
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01690429
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.90821647
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90784454
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87752486
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86574184
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80138317
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76105107
29SPI1_23547873_ChIP-Seq_NB4_Human1.70777051
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69853739
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68721658
32* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64226856
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.63868274
34KDM2B_26808549_Chip-Seq_DND41_Human1.61895950
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.60527358
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59861948
37* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59438048
38ZNF263_19887448_ChIP-Seq_K562_Human1.57818157
39GATA1_22025678_ChIP-Seq_K562_Human1.55357915
40TCF7_22412390_ChIP-Seq_EML_Mouse1.53367031
41VDR_21846776_ChIP-Seq_THP-1_Human1.52001620
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50323089
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49421186
44* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47307127
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.47242169
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46828689
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46826973
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46491268
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44679200
50CLOCK_20551151_ChIP-Seq_293T_Human1.44311868
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.44049617
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43118780
53* ELF1_20517297_ChIP-Seq_JURKAT_Human1.42794931
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.42182802
55* P68_20966046_ChIP-Seq_HELA_Human1.41294945
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41280369
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39292139
58* VDR_24763502_ChIP-Seq_THP-1_Human1.37750996
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37501326
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36792694
61* ELK3_25401928_ChIP-Seq_HUVEC_Human1.36638198
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36463848
63* SA1_27219007_Chip-Seq_ERYTHROID_Human1.36015554
64BCL6_27268052_Chip-Seq_Bcells_Human1.33451474
65TFEB_21752829_ChIP-Seq_HELA_Human1.33375068
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33116684
67MAF_26560356_Chip-Seq_TH1_Human1.32834871
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32602591
69MAF_26560356_Chip-Seq_TH2_Human1.31192396
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30866884
71* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30641752
72* BCOR_27268052_Chip-Seq_Bcells_Human1.30347227
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29966091
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29407974
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27761809
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.27096727
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.26937681
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25828847
79MYB_26560356_Chip-Seq_TH2_Human1.25140279
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.24101185
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23378831
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22548567
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21944346
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19590534
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18045026
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18016603
87SOX2_20726797_ChIP-Seq_SW620_Human1.17082854
88KDM2B_26808549_Chip-Seq_K562_Human1.16664401
89TP53_22127205_ChIP-Seq_IMR90_Human1.16146183
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15903444
91* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15271308
92ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14360669
93SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14310625
94NCOR1_26117541_ChIP-Seq_K562_Human1.13955062
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12939310
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12841721
97SCL_19346495_ChIP-Seq_HPC-7_Human1.12685599
98PU_27001747_Chip-Seq_BMDM_Mouse1.11989715
99LXR_22292898_ChIP-Seq_THP-1_Human1.11655427
100GATA1_19941827_ChIP-Seq_MEL_Mouse1.10450160
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10391458
102* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10332605
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10069423
104GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10024857
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07936350
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07792329
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07404101
108KDM2B_26808549_Chip-Seq_JURKAT_Human1.07046421
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06509806
110PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06439367
111* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06345369
112* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06345369
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06121933
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06039977
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.05466275
116ATF3_27146783_Chip-Seq_COLON_Human1.05068578
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05020713
118* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04514310
119SPI1_23127762_ChIP-Seq_K562_Human1.04052246
120SMC4_20622854_ChIP-Seq_HELA_Human1.03790079
121CTCF_26484167_Chip-Seq_Bcells_Mouse1.03451619
122CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02853557
123* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02783190
124STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02428745
125SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02091546
126RACK7_27058665_Chip-Seq_MCF-7_Human1.02066339
127GATA4_25053715_ChIP-Seq_YYC3_Human1.02024637
128UTX_26944678_Chip-Seq_JUKART_Human1.01630401
129* UBF1/2_26484160_Chip-Seq_HMECs_Human1.00555324
130SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00253528
131CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99549386
132SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99110179
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98590964
134MYC_22102868_ChIP-Seq_BL_Human0.97453243
135PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96929144
136* MYB_26560356_Chip-Seq_TH1_Human0.96565962
137GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96042465
138PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94573556
139STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94036379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.31049368
2MP0003436_decreased_susceptibility_to3.12490022
3MP0001835_abnormal_antigen_presentation3.04911861
4MP0009840_abnormal_foam_cell2.39148826
5MP0009785_altered_susceptibility_to2.37230680
6MP0003191_abnormal_cellular_cholesterol2.32883545
7MP0002419_abnormal_innate_immunity2.21909344
8MP0002148_abnormal_hypersensitivity_rea2.21663533
9MP0006082_CNS_inflammation2.20633886
10MP0008438_abnormal_cutaneous_collagen2.13285101
11MP0003705_abnormal_hypodermis_morpholog2.06966328
12MP0003303_peritoneal_inflammation2.06508874
13MP0005025_abnormal_response_to2.02604673
14MP0005451_abnormal_body_composition2.01838603
15MP0005000_abnormal_immune_tolerance2.00829549
16MP0003172_abnormal_lysosome_physiology1.97891156
17MP0005083_abnormal_biliary_tract1.95951438
18MP0008260_abnormal_autophagy1.95357826
19MP0001533_abnormal_skeleton_physiology1.83479007
20MP0003724_increased_susceptibility_to1.80465237
21MP0001790_abnormal_immune_system1.79359311
22MP0005387_immune_system_phenotype1.79359311
23MP0004947_skin_inflammation1.78436119
24MP0000685_abnormal_immune_system1.77594212
25MP0003566_abnormal_cell_adhesion1.76928936
26MP0002452_abnormal_antigen_presenting1.74835180
27MP0005464_abnormal_platelet_physiology1.70633355
28MP0003329_amyloid_beta_deposits1.59905923
29MP0005275_abnormal_skin_tensile1.59242459
30MP0001800_abnormal_humoral_immune1.57672796
31MP0002723_abnormal_immune_serum1.57260052
32MP0001845_abnormal_inflammatory_respons1.56088524
33MP0003300_gastrointestinal_ulcer1.55515907
34MP0001853_heart_inflammation1.53527409
35MP0003186_abnormal_redox_activity1.52908334
36MP0003091_abnormal_cell_migration1.51601937
37MP0002405_respiratory_system_inflammati1.47971563
38MP0008469_abnormal_protein_level1.46030831
39MP0000343_altered_response_to1.45517814
40MP0001819_abnormal_immune_cell1.44074993
41MP0000751_myopathy1.43915316
42MP0002420_abnormal_adaptive_immunity1.43885633
43MP0000858_altered_metastatic_potential1.41060982
44MP0010155_abnormal_intestine_physiology1.40832437
45MP0002139_abnormal_hepatobiliary_system1.38078875
46MP0005671_abnormal_response_to1.36464638
47MP0005365_abnormal_bile_salt1.36197702
48MP0004272_abnormal_basement_membrane1.34981629
49MP0002254_reproductive_system_inflammat1.31191788
50MP0002933_joint_inflammation1.30849795
51MP0001849_ear_inflammation1.30787765
52MP0003448_altered_tumor_morphology1.30334091
53MP0005257_abnormal_intraocular_pressure1.29407489
54MP0003195_calcinosis1.28887783
55MP0001958_emphysema1.28802007
56MP0001666_abnormal_nutrient_absorption1.28655506
57MP0010234_abnormal_vibrissa_follicle1.26610328
58MP0005503_abnormal_tendon_morphology1.24314151
59MP0006054_spinal_hemorrhage1.23782940
60MP0005165_increased_susceptibility_to1.23508764
61MP0005023_abnormal_wound_healing1.23424976
62MP0002060_abnormal_skin_morphology1.23115141
63MP0003453_abnormal_keratinocyte_physiol1.22762172
64MP0005360_urolithiasis1.22643752
65MP0002166_altered_tumor_susceptibility1.22636268
66MP0004782_abnormal_surfactant_physiolog1.21007418
67MP0010352_gastrointestinal_tract_polyps1.20276677
68MP0009764_decreased_sensitivity_to1.19495584
69MP0008875_abnormal_xenobiotic_pharmacok1.19130639
70MP0003828_pulmonary_edema1.17162464
71MP0003806_abnormal_nucleotide_metabolis1.17004253
72MP0002998_abnormal_bone_remodeling1.15717075
73MP0000465_gastrointestinal_hemorrhage1.15360367
74MP0004858_abnormal_nervous_system1.14177591
75MP0009333_abnormal_splenocyte_physiolog1.12683043
76MP0003183_abnormal_peptide_metabolism1.11810669
77MP0000767_abnormal_smooth_muscle1.10564298
78MP0002138_abnormal_hepatobiliary_system1.10421105
79MP0000604_amyloidosis1.05865449
80MP0002796_impaired_skin_barrier1.05209189
81MP0005397_hematopoietic_system_phenotyp1.04547140
82MP0001545_abnormal_hematopoietic_system1.04547140
83MP0009643_abnormal_urine_homeostasis1.04372043
84MP0005390_skeleton_phenotype1.04127173
85MP0003656_abnormal_erythrocyte_physiolo1.03212240
86MP0004510_myositis1.01696182
87MP0000716_abnormal_immune_system1.01480769
88MP0001873_stomach_inflammation0.99006936
89MP0000689_abnormal_spleen_morphology0.98879822
90MP0002006_tumorigenesis0.98562990
91MP0005164_abnormal_response_to0.98062582
92MP0000490_abnormal_crypts_of0.97784246
93MP0002877_abnormal_melanocyte_morpholog0.97000195
94MP0005319_abnormal_enzyme/_coenzyme0.96610067
95MP0000747_muscle_weakness0.95280908
96MP0003763_abnormal_thymus_physiology0.94909900
97MP0000750_abnormal_muscle_regeneration0.94046771
98MP0003795_abnormal_bone_structure0.93851789
99MP0003279_aneurysm0.93663095
100MP0010307_abnormal_tumor_latency0.93433959
101MP0001851_eye_inflammation0.93431546
102MP0001216_abnormal_epidermal_layer0.93112061
103MP0000609_abnormal_liver_physiology0.92998580
104MP0003075_altered_response_to0.91193659
105MP0003950_abnormal_plasma_membrane0.90590160
106MP0010329_abnormal_lipoprotein_level0.90383981
107MP0000015_abnormal_ear_pigmentation0.89696931
108MP0005310_abnormal_salivary_gland0.88685495
109MP0002429_abnormal_blood_cell0.88581627
110MP0005085_abnormal_gallbladder_physiolo0.88483468
111MP0002398_abnormal_bone_marrow0.87348095
112MP0009763_increased_sensitivity_to0.87341181
113MP0005166_decreased_susceptibility_to0.87293482
114MP0009278_abnormal_bone_marrow0.87105944
115MP0002722_abnormal_immune_system0.86798988
116MP0002136_abnormal_kidney_physiology0.86706944
117MP0001243_abnormal_dermal_layer0.84986715
118MP0000249_abnormal_blood_vessel0.84699443
119MP0005501_abnormal_skin_physiology0.84696774
120MP0001542_abnormal_bone_strength0.83807678
121MP0005508_abnormal_skeleton_morphology0.81070735
122MP0002295_abnormal_pulmonary_circulatio0.76533297
123MP0009384_cardiac_valve_regurgitation0.76508793
124MP0005330_cardiomyopathy0.76003601
125MP0002896_abnormal_bone_mineralization0.75862092
126MP0002332_abnormal_exercise_endurance0.75299049
127MP0008004_abnormal_stomach_pH0.74491236
128MP0005595_abnormal_vascular_smooth0.74040779
129MP0000733_abnormal_muscle_development0.73313907
130MP0005076_abnormal_cell_differentiation0.72879799
131MP0000681_abnormal_thyroid_gland0.72679595

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)5.11400910
2Increased cerebral lipofuscin (HP:0011813)4.68144177
3Recurrent abscess formation (HP:0002722)4.53294599
4Eczematoid dermatitis (HP:0000976)4.31825519
5Increased neuronal autofluorescent lipopigment (HP:0002074)4.15383117
6Recurrent gram-negative bacterial infections (HP:0005420)4.02732176
7Recurrent bacterial skin infections (HP:0005406)3.92870035
8Dysostosis multiplex (HP:0000943)3.77339854
9Abnormality of macrophages (HP:0004311)3.64382308
10Mucopolysacchariduria (HP:0008155)3.45282168
11Urinary glycosaminoglycan excretion (HP:0003541)3.45282168
12Axonal loss (HP:0003447)3.41677647
13Systemic lupus erythematosus (HP:0002725)3.35842772
14Elevated erythrocyte sedimentation rate (HP:0003565)3.27924497
15Interstitial pulmonary disease (HP:0006530)3.26161472
16Abnormality of polysaccharide metabolism (HP:0011012)3.11262666
17Abnormality of glycosaminoglycan metabolism (HP:0004371)3.11262666
18Abnormality of mucopolysaccharide metabolism (HP:0011020)3.11262666
19Abnormality of glycolipid metabolism (HP:0010969)3.00348223
20Abnormality of liposaccharide metabolism (HP:0010968)3.00348223
21Abnormality of glycosphingolipid metabolism (HP:0004343)3.00348223
22Vertebral compression fractures (HP:0002953)2.96019539
23Myositis (HP:0100614)2.93563604
24Myocardial infarction (HP:0001658)2.89341864
25Distal lower limb muscle weakness (HP:0009053)2.82730507
26Increased connective tissue (HP:0009025)2.80546110
27Beaking of vertebral bodies (HP:0004568)2.65527815
28Cerebral aneurysm (HP:0004944)2.56154510
29Loss of speech (HP:0002371)2.55085440
30Achilles tendon contracture (HP:0001771)2.54187668
31Distal lower limb amyotrophy (HP:0008944)2.51004549
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.48860247
33Gingivitis (HP:0000230)2.45593334
34Cervical subluxation (HP:0003308)2.45586331
35Orchitis (HP:0100796)2.44998388
36Mediastinal lymphadenopathy (HP:0100721)2.44047103
37Spinal rigidity (HP:0003306)2.42212081
38Atrophic scars (HP:0001075)2.40255167
39Autoimmune thrombocytopenia (HP:0001973)2.40245864
40Recurrent skin infections (HP:0001581)2.39346639
41Urticaria (HP:0001025)2.39340843
42Petechiae (HP:0000967)2.36887153
43Distal upper limb amyotrophy (HP:0007149)2.34979102
44Upper limb amyotrophy (HP:0009129)2.34979102
45Spondylolisthesis (HP:0003302)2.34413006
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.31191812
47Fragile skin (HP:0001030)2.28624836
48Dilatation of the ascending aorta (HP:0005111)2.27195163
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.25880047
50Osteolytic defects of the hand bones (HP:0009699)2.25880047
51Periodontitis (HP:0000704)2.24385402
52Joint stiffness (HP:0001387)2.24375639
53Abnormality of the Achilles tendon (HP:0005109)2.23559135
54Increased variability in muscle fiber diameter (HP:0003557)2.22857430
55Thrombocytosis (HP:0001894)2.22577475
56Xanthomatosis (HP:0000991)2.22050743
57Short nail (HP:0001799)2.20483308
58Chronic otitis media (HP:0000389)2.20362869
59Nuclear cataract (HP:0100018)2.20111190
60Pustule (HP:0200039)2.19158090
61Abnormality of the lumbar spine (HP:0100712)2.18147590
62Ankle contracture (HP:0006466)2.18005480
63Aortic aneurysm (HP:0004942)2.16667243
64Obstructive lung disease (HP:0006536)2.12497064
65Chronic obstructive pulmonary disease (HP:0006510)2.12497064
66Generalized amyotrophy (HP:0003700)2.11354732
67Prolonged neonatal jaundice (HP:0006579)2.10470177
68Thoracic kyphosis (HP:0002942)2.10028746
69Cellulitis (HP:0100658)2.09081219
70Hepatosplenomegaly (HP:0001433)2.08892975
71Joint hemorrhage (HP:0005261)2.08728386
72Thin bony cortex (HP:0002753)2.08124273
73Pathologic fracture (HP:0002756)2.06820050
74Abnormality of skeletal muscle fiber size (HP:0012084)2.06131463
75Wormian bones (HP:0002645)2.05653288
76J-shaped sella turcica (HP:0002680)2.05087311
77Abnormality of complement system (HP:0005339)2.05074311
78Tetraparesis (HP:0002273)2.03907315
79Abnormality of the vasculature of the conjunctiva (HP:0008054)2.02121364
80Peritonitis (HP:0002586)2.01414358
81Recurrent fungal infections (HP:0002841)2.00681916
82Blue sclerae (HP:0000592)1.99849819
83Elbow flexion contracture (HP:0002987)1.98395725
84Disinhibition (HP:0000734)1.97572333
85Neurofibrillary tangles (HP:0002185)1.97130323
86Hypertensive crisis (HP:0100735)1.96645223
87Centrally nucleated skeletal muscle fibers (HP:0003687)1.96000990
88Progressive neurologic deterioration (HP:0002344)1.95486780
89Aortic dissection (HP:0002647)1.95360507
90Type 1 muscle fiber predominance (HP:0003803)1.94598006
91Abnormality of the nasal mucosa (HP:0000433)1.93681234
92Bladder diverticulum (HP:0000015)1.93565459
93Reduced subcutaneous adipose tissue (HP:0003758)1.91957923
94Natal tooth (HP:0000695)1.91900243
95Abnormality of the common coagulation pathway (HP:0010990)1.90807660
96Mitral regurgitation (HP:0001653)1.90625210
97Nasal polyposis (HP:0100582)1.90011136
98Premature rupture of membranes (HP:0001788)1.89708602
99Protuberant abdomen (HP:0001538)1.89515012
100Vasculitis (HP:0002633)1.89300399
101Genu recurvatum (HP:0002816)1.89171988
102Mildly elevated creatine phosphokinase (HP:0008180)1.87589073
103Upper motor neuron abnormality (HP:0002127)1.87486854
104Hyperacusis (HP:0010780)1.87167702
105Basal ganglia calcification (HP:0002135)1.86852637
106Glomerulonephritis (HP:0000099)1.85805303
107Osteomyelitis (HP:0002754)1.84469948
108Slender build (HP:0001533)1.83804146
109Increased serum ferritin (HP:0003281)1.83682934
110Nausea (HP:0002018)1.83617814
111Hand muscle atrophy (HP:0009130)1.83490082
112Poor head control (HP:0002421)1.82562067
113Ovoid vertebral bodies (HP:0003300)1.82297766
114Hematochezia (HP:0002573)1.81652673
115Steatorrhea (HP:0002570)1.81261121
116Aneurysm (HP:0002617)1.80494728
117Hypertriglyceridemia (HP:0002155)1.80404988
118Asymmetric septal hypertrophy (HP:0001670)1.79564678
119Thick nail (HP:0001805)1.78295660
120Cholecystitis (HP:0001082)1.77025398
121Abnormal gallbladder physiology (HP:0012438)1.77025398
122Polycythemia (HP:0001901)1.76639931
123Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76144343
124Increased IgE level (HP:0003212)1.76118164
125Abnormality of the intrinsic pathway (HP:0010989)1.76041362
126Abnormality of the distal phalanges of the toes (HP:0010182)1.75962768
127Biconcave vertebral bodies (HP:0004586)1.74892457
128Abnormality of iron homeostasis (HP:0011031)1.74314454
129Protrusio acetabuli (HP:0003179)1.74251512
130Gingival bleeding (HP:0000225)1.74071649
131Cerebral inclusion bodies (HP:0100314)1.73834741
132IgM deficiency (HP:0002850)1.73580453
133Broad face (HP:0000283)1.73369461
134Esophageal varix (HP:0002040)1.73339518
135Skin ulcer (HP:0200042)1.72860071
136Polygenic inheritance (HP:0010982)1.72309368
137Vascular tortuosity (HP:0004948)1.71409754
138Hemorrhage of the eye (HP:0011885)1.70760073
139Rough bone trabeculation (HP:0100670)1.70608099
140Amyloidosis (HP:0011034)1.70544406
141Mucosal telangiectasiae (HP:0100579)1.70449225
142Stomatitis (HP:0010280)1.70326407
143Nephritis (HP:0000123)1.70042567
144Abnormality of the thoracic spine (HP:0100711)1.69969629
145Menorrhagia (HP:0000132)1.69543224
146Spontaneous hematomas (HP:0007420)1.69532462
147Purpura (HP:0000979)1.69044243
148Bone pain (HP:0002653)1.68243439
149Emphysema (HP:0002097)1.67980457
150Complement deficiency (HP:0004431)1.67744613
151Bulbar palsy (HP:0001283)1.67741710
152Epistaxis (HP:0000421)1.66641139
153Recurrent bronchitis (HP:0002837)1.66500112
154Recurrent viral infections (HP:0004429)1.65310026
155Nonimmune hydrops fetalis (HP:0001790)1.65271990
156Difficulty climbing stairs (HP:0003551)1.64649443
157Hydroxyprolinuria (HP:0003080)1.64191330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.94044728
2NME23.05625785
3TRIB32.98598245
4TBK12.96299090
5PRPF4B2.71441060
6MAP3K32.57918847
7PIM22.48208873
8MAP4K12.39490151
9KIT2.36482032
10MAP3K142.35708141
11BLK2.34743124
12SMG12.30377404
13TYK22.23955782
14IRAK32.12333527
15MAP2K32.10454342
16LIMK11.83147125
17PKN21.82610189
18LRRK21.76392617
19BCKDK1.76161793
20IRAK41.70368116
21PBK1.64671412
22MAP3K111.63883952
23NEK91.62498693
24ZAP701.62430574
25FLT31.55145633
26IKBKB1.54635165
27JAK31.52965830
28IKBKE1.51154460
29DDR21.50179316
30TGFBR21.49123989
31ICK1.46502169
32RPS6KA41.45903718
33MST1R1.40657042
34TTN1.37281574
35TAOK31.36646224
36MAP3K101.36353090
37PTK61.34715170
38PIK3CG1.32488778
39TRPM71.32004042
40CSF1R1.29680669
41MST41.26716257
42LMTK21.23206863
43TESK11.22871560
44EPHB11.20692573
45FGFR41.19951478
46BTK1.18162393
47STK101.15418963
48PDGFRA1.15301496
49CDC42BPA1.12806925
50MAPKAPK31.11667184
51PRKD21.09957289
52JAK11.08157664
53MAP2K21.05819265
54PAK41.04763787
55ABL21.03314751
56MAP3K131.01600914
57TEC1.01597987
58GRK70.98273544
59CSK0.95758227
60SYK0.89588683
61MATK0.88867681
62HCK0.88172137
63CHUK0.87864185
64PDPK10.84360640
65KDR0.82846278
66MAP3K60.82755475
67MOS0.81911473
68TGFBR10.80577587
69EPHA20.80535308
70RPS6KA20.78676011
71SCYL20.77454664
72EPHB20.75526616
73MAP3K10.74341096
74LYN0.72867904
75MAPK110.72689408
76BMX0.72269950
77GRK60.71340106
78PIM10.71224556
79MAPK120.71122997
80RIPK40.70450293
81EPHA30.69205124
82HIPK20.68668078
83SIK10.68541339
84LCK0.66733800
85JAK20.65096290
86ILK0.64781860
87TAOK20.63504910
88RPS6KB20.62968444
89PRKG20.62587085
90PRKD30.62367412
91ITK0.62260401
92MAP3K20.60948184
93TESK20.60593310
94PAK20.60430844
95EEF2K0.58705649
96PAK10.58302105
97TXK0.57684583
98VRK20.56296696
99MAPKAPK20.54730717
100MAPK70.54014004
101MAP2K10.53803113
102DAPK10.53026729
103IRAK20.52608709
104RPS6KA60.51539077
105ARAF0.51408444
106CDK60.51113036
107MARK20.50850212
108STK240.50681768
109FES0.50539640
110RIPK10.48950680
111ERBB30.48892153
112BRAF0.48661145
113ABL10.48269862
114PRKCD0.47147893
115DAPK30.46623321
116MAPK150.44664811
117PDK10.44456366
118EGFR0.43981561
119TAOK10.43598696
120EIF2AK30.43017507
121PRKD10.42856390
122MAP3K80.42101098
123MAPK40.41783267
124MTOR0.41751577
125PTK20.41582765
126MET0.41330737
127RPS6KC10.40968014
128RPS6KL10.40968014
129MAP3K50.40957786
130KSR20.40439856
131CAMKK20.39689374
132MYLK0.37563423
133FGR0.36301259
134FGFR30.35963960
135DYRK1B0.35608297

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysosome_Homo sapiens_hsa041422.89284008
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.59614300
3Other glycan degradation_Homo sapiens_hsa005112.58984823
4Leishmaniasis_Homo sapiens_hsa051402.40313589
5Staphylococcus aureus infection_Homo sapiens_hsa051502.38138517
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.09959109
7Legionellosis_Homo sapiens_hsa051341.95172962
8Caffeine metabolism_Homo sapiens_hsa002321.85642012
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.79374509
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72663966
11Pertussis_Homo sapiens_hsa051331.69878180
12Phagosome_Homo sapiens_hsa041451.68418646
13Antigen processing and presentation_Homo sapiens_hsa046121.62713129
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.61974707
15Osteoclast differentiation_Homo sapiens_hsa043801.61655737
16Malaria_Homo sapiens_hsa051441.60907035
17Tuberculosis_Homo sapiens_hsa051521.57853333
18Complement and coagulation cascades_Homo sapiens_hsa046101.50661932
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.46749673
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45989512
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44538107
22Fructose and mannose metabolism_Homo sapiens_hsa000511.43187879
23Histidine metabolism_Homo sapiens_hsa003401.38372694
24Rheumatoid arthritis_Homo sapiens_hsa053231.31370619
25Apoptosis_Homo sapiens_hsa042101.30110052
26Prion diseases_Homo sapiens_hsa050201.28494247
27Protein export_Homo sapiens_hsa030601.27148960
28Toxoplasmosis_Homo sapiens_hsa051451.23422668
29Folate biosynthesis_Homo sapiens_hsa007901.19346773
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17681662
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17484204
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15100519
33Autoimmune thyroid disease_Homo sapiens_hsa053201.14992941
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13549995
35Measles_Homo sapiens_hsa051621.09764739
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.07515710
37Influenza A_Homo sapiens_hsa051641.07212848
38Focal adhesion_Homo sapiens_hsa045101.06450696
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06340009
40Shigellosis_Homo sapiens_hsa051311.06315281
41Chronic myeloid leukemia_Homo sapiens_hsa052201.05573808
42Sulfur relay system_Homo sapiens_hsa041221.03632263
43Endocytosis_Homo sapiens_hsa041441.03204614
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.01466152
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00905107
46VEGF signaling pathway_Homo sapiens_hsa043701.00696432
47TNF signaling pathway_Homo sapiens_hsa046681.00516337
48Ribosome_Homo sapiens_hsa030101.00108073
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99676283
50Fat digestion and absorption_Homo sapiens_hsa049750.99033278
51B cell receptor signaling pathway_Homo sapiens_hsa046620.98015520
52Salmonella infection_Homo sapiens_hsa051320.97997770
53Chemical carcinogenesis_Homo sapiens_hsa052040.97976621
54Starch and sucrose metabolism_Homo sapiens_hsa005000.96673369
55Sulfur metabolism_Homo sapiens_hsa009200.94557167
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94250942
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.93320810
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92831093
59Galactose metabolism_Homo sapiens_hsa000520.92757761
60Glutathione metabolism_Homo sapiens_hsa004800.91887952
61Proteasome_Homo sapiens_hsa030500.91830731
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.89424704
63Fatty acid degradation_Homo sapiens_hsa000710.88720025
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.88189364
65Pancreatic cancer_Homo sapiens_hsa052120.87611124
66Hematopoietic cell lineage_Homo sapiens_hsa046400.84014527
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82801339
68Renin-angiotensin system_Homo sapiens_hsa046140.81404977
69Vibrio cholerae infection_Homo sapiens_hsa051100.80777378
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80340582
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.78973852
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78813016
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78378084
74Pentose phosphate pathway_Homo sapiens_hsa000300.78107487
75Amoebiasis_Homo sapiens_hsa051460.77716065
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.77539089
77Peroxisome_Homo sapiens_hsa041460.77291556
78Notch signaling pathway_Homo sapiens_hsa043300.77079762
79Graft-versus-host disease_Homo sapiens_hsa053320.76619193
80Hepatitis C_Homo sapiens_hsa051600.76151019
81Tryptophan metabolism_Homo sapiens_hsa003800.76048688
82Phenylalanine metabolism_Homo sapiens_hsa003600.74846047
83Proteoglycans in cancer_Homo sapiens_hsa052050.73793667
84Selenocompound metabolism_Homo sapiens_hsa004500.73595461
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73296095
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72503959
87Sphingolipid metabolism_Homo sapiens_hsa006000.72423375
88PPAR signaling pathway_Homo sapiens_hsa033200.72259457
89Steroid biosynthesis_Homo sapiens_hsa001000.68740257
90beta-Alanine metabolism_Homo sapiens_hsa004100.68259276
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.67860703
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67633274
93HTLV-I infection_Homo sapiens_hsa051660.67420827
94Herpes simplex infection_Homo sapiens_hsa051680.63345032
95Non-small cell lung cancer_Homo sapiens_hsa052230.61615621
96Allograft rejection_Homo sapiens_hsa053300.61438382
97N-Glycan biosynthesis_Homo sapiens_hsa005100.61000361
98Arachidonic acid metabolism_Homo sapiens_hsa005900.60832279
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60765443
100Protein digestion and absorption_Homo sapiens_hsa049740.60562664
101Platelet activation_Homo sapiens_hsa046110.60125656
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59753561
103Small cell lung cancer_Homo sapiens_hsa052220.58647387
104Asthma_Homo sapiens_hsa053100.58214191
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57987595
106Hepatitis B_Homo sapiens_hsa051610.57865406
107Type I diabetes mellitus_Homo sapiens_hsa049400.57199966
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56411789
109Chemokine signaling pathway_Homo sapiens_hsa040620.55871274
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54890575
111Viral carcinogenesis_Homo sapiens_hsa052030.54491340
112Acute myeloid leukemia_Homo sapiens_hsa052210.54143898
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53531076
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.53033992
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52858516
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52701285
117Epstein-Barr virus infection_Homo sapiens_hsa051690.51061199
118Collecting duct acid secretion_Homo sapiens_hsa049660.50451793
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50148254
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.50145868
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49356843
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49106496
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.48130484
124ECM-receptor interaction_Homo sapiens_hsa045120.47055843
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46796673
126HIF-1 signaling pathway_Homo sapiens_hsa040660.46718043
127Bladder cancer_Homo sapiens_hsa052190.46697103
128Retinol metabolism_Homo sapiens_hsa008300.45428757
129Renal cell carcinoma_Homo sapiens_hsa052110.44974331
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.44766367
131Viral myocarditis_Homo sapiens_hsa054160.44685512
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43157131
133Arginine biosynthesis_Homo sapiens_hsa002200.42532507

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