RNLS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.71494834
2axonemal dynein complex assembly (GO:0070286)8.76513183
3multicellular organism reproduction (GO:0032504)8.18965690
4sperm motility (GO:0030317)8.13955531
5male meiosis (GO:0007140)7.85372213
6sperm-egg recognition (GO:0035036)7.62619991
7plasma membrane fusion (GO:0045026)7.12465313
8binding of sperm to zona pellucida (GO:0007339)6.93194194
9epithelial cilium movement (GO:0003351)6.90120304
10synaptonemal complex organization (GO:0070193)6.87462910
11cell-cell recognition (GO:0009988)6.84131118
12DNA methylation involved in gamete generation (GO:0043046)6.61223013
13reproduction (GO:0000003)6.59584596
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.59420095
15motile cilium assembly (GO:0044458)6.58785798
16acrosome reaction (GO:0007340)6.45860525
17acrosome assembly (GO:0001675)6.40434115
18cilium movement (GO:0003341)6.40213732
19regulation of cilium movement (GO:0003352)6.20948257
20spermatid development (GO:0007286)6.19891579
21synaptonemal complex assembly (GO:0007130)6.19856084
22single fertilization (GO:0007338)5.91145014
23sperm capacitation (GO:0048240)5.61588121
24male meiosis I (GO:0007141)5.57316061
25intraciliary transport (GO:0042073)5.28596057
26cell wall macromolecule catabolic process (GO:0016998)5.25378746
27cell wall macromolecule metabolic process (GO:0044036)5.25378746
28fertilization (GO:0009566)5.10167684
29protein localization to cilium (GO:0061512)4.99808394
30chromosome organization involved in meiosis (GO:0070192)4.84430200
31meiotic cell cycle (GO:0051321)4.67793147
32meiosis I (GO:0007127)4.49972692
33meiotic nuclear division (GO:0007126)4.46782565
34negative regulation of inclusion body assembly (GO:0090084)4.41238491
35valine metabolic process (GO:0006573)4.35335931
36cellular ketone body metabolic process (GO:0046950)4.27189649
37axoneme assembly (GO:0035082)4.09267535
38spermatogenesis (GO:0007283)4.07937232
39microtubule severing (GO:0051013)4.07176007
40male gamete generation (GO:0048232)4.06850994
41ketone body metabolic process (GO:1902224)3.95611889
42protein complex biogenesis (GO:0070271)3.83687393
43proteasome assembly (GO:0043248)3.81050050
44replication fork processing (GO:0031297)3.78782306
45protein polyglutamylation (GO:0018095)3.77658448
46gamete generation (GO:0007276)3.77303883
47cellular process involved in reproduction in multicellular organism (GO:0022412)3.76667769
48seminiferous tubule development (GO:0072520)3.75219370
49germ cell development (GO:0007281)3.72458991
50maturation of 5.8S rRNA (GO:0000460)3.70642675
51signal peptide processing (GO:0006465)3.69975211
52synapsis (GO:0007129)3.67073698
53regulation of microtubule-based movement (GO:0060632)3.66850821
54respiratory chain complex IV assembly (GO:0008535)3.65323029
55branched-chain amino acid catabolic process (GO:0009083)3.62554165
56regulation of mitochondrial translation (GO:0070129)3.48893370
57mitochondrial respiratory chain complex assembly (GO:0033108)3.47433171
58cytochrome complex assembly (GO:0017004)3.44852183
59ubiquinone biosynthetic process (GO:0006744)3.42996724
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.36099817
61regulation of inclusion body assembly (GO:0090083)3.33107537
62lactate metabolic process (GO:0006089)3.31575004
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.24123530
64L-phenylalanine catabolic process (GO:0006559)3.24123530
65organic cation transport (GO:0015695)3.23357529
66regulation of meiosis I (GO:0060631)3.21577706
67gene silencing by RNA (GO:0031047)3.20640917
68xenobiotic catabolic process (GO:0042178)3.20558544
69cullin deneddylation (GO:0010388)3.20029678
70mitochondrial respiratory chain complex I assembly (GO:0032981)3.19631035
71NADH dehydrogenase complex assembly (GO:0010257)3.19631035
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19631035
73branched-chain amino acid metabolic process (GO:0009081)3.19165592
74ventricular system development (GO:0021591)3.18450883
75mannosylation (GO:0097502)3.17809656
76DNA deamination (GO:0045006)3.17348242
77water-soluble vitamin biosynthetic process (GO:0042364)3.17024814
78transcription elongation from RNA polymerase III promoter (GO:0006385)3.12057555
79termination of RNA polymerase III transcription (GO:0006386)3.12057555
80mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.11763761
81response to nitrosative stress (GO:0051409)3.09585153
82glycerol metabolic process (GO:0006071)3.06275872
83sphingosine metabolic process (GO:0006670)3.05702013
84sphingoid metabolic process (GO:0046519)3.04017510
85axon ensheathment in central nervous system (GO:0032291)3.03031640
86central nervous system myelination (GO:0022010)3.03031640
87genitalia morphogenesis (GO:0035112)3.02477823
88nucleoside diphosphate catabolic process (GO:0009134)3.00251415
89centriole replication (GO:0007099)2.98566528
90quinone biosynthetic process (GO:1901663)2.97558700
91ubiquinone metabolic process (GO:0006743)2.95740254
92cilium organization (GO:0044782)2.95463422
93dopamine transport (GO:0015872)2.93742788
94erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.93428929
95L-phenylalanine metabolic process (GO:0006558)2.93428929
96regulation of hexokinase activity (GO:1903299)2.92835891
97regulation of glucokinase activity (GO:0033131)2.92835891
98magnesium ion transport (GO:0015693)2.92605672
99cell recognition (GO:0008037)2.92107850
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.91781286
101tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.91781286
102regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.91761754
103respiratory electron transport chain (GO:0022904)2.91599466
104glutathione derivative metabolic process (GO:1901685)2.90814184
105glutathione derivative biosynthetic process (GO:1901687)2.90814184
106cilium morphogenesis (GO:0060271)2.89736364
107aromatic amino acid family catabolic process (GO:0009074)2.88918568
108protein deneddylation (GO:0000338)2.88878075
109aspartate family amino acid catabolic process (GO:0009068)2.87323425
110cilium assembly (GO:0042384)2.86333861
111electron transport chain (GO:0022900)2.85917740
112pteridine-containing compound biosynthetic process (GO:0042559)2.84522038
113succinate metabolic process (GO:0006105)2.84226026
114pseudouridine synthesis (GO:0001522)2.83880117
115multicellular organismal reproductive process (GO:0048609)2.83792734
116regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.80817794
117negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.80789276
118regulation of protein glycosylation (GO:0060049)2.79522156
119GTP biosynthetic process (GO:0006183)2.79085593
120meiotic cell cycle process (GO:1903046)2.78196984
121establishment of protein localization to mitochondrial membrane (GO:0090151)2.78088927
122negative regulation of skeletal muscle tissue development (GO:0048642)2.77662859
123regulation of cellular amino acid metabolic process (GO:0006521)2.77459230
124positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77141304
125negative regulation of necroptotic process (GO:0060546)2.76309334
126energy coupled proton transport, down electrochemical gradient (GO:0015985)2.73108749
127ATP synthesis coupled proton transport (GO:0015986)2.73108749
128alditol metabolic process (GO:0019400)2.72989557
129negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.72942353
130diol metabolic process (GO:0034311)2.72927087
131maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71976703
132protein refolding (GO:0042026)2.71148854
133ribonucleoprotein complex disassembly (GO:0032988)2.70529551
134somatic hypermutation of immunoglobulin genes (GO:0016446)2.68597069
135somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68597069
136cellular component assembly involved in morphogenesis (GO:0010927)2.67439777
137adenosine metabolic process (GO:0046085)2.67386899
138regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.65874863
139positive regulation of histone H3-K4 methylation (GO:0051571)2.65626764
140quinone metabolic process (GO:1901661)2.64988211
141negative regulation of transcription by competitive promoter binding (GO:0010944)2.62711964
142positive regulation of meiosis (GO:0045836)2.60428309
143centriole assembly (GO:0098534)2.60300511
144regulation of necroptotic process (GO:0060544)2.60100484
145microtubule depolymerization (GO:0007019)2.59340157
146glycerol ether metabolic process (GO:0006662)2.58820926
147meiotic chromosome segregation (GO:0045132)2.57844810
148indole-containing compound catabolic process (GO:0042436)2.57625268
149indolalkylamine catabolic process (GO:0046218)2.57625268
150tryptophan catabolic process (GO:0006569)2.57625268
151translesion synthesis (GO:0019985)2.54605442
152negative regulation of DNA-dependent DNA replication (GO:2000104)2.54315335
153preassembly of GPI anchor in ER membrane (GO:0016254)2.54291121
154aldehyde catabolic process (GO:0046185)2.53905548
155negative regulation of ligase activity (GO:0051352)2.53558185
156negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.53558185
157DNA catabolic process, exonucleolytic (GO:0000738)2.52172844
158regulation of acyl-CoA biosynthetic process (GO:0050812)2.51017208
159negative regulation of telomere maintenance (GO:0032205)2.49466370
160regulation of rhodopsin mediated signaling pathway (GO:0022400)2.48711805
161left/right pattern formation (GO:0060972)2.48148034
162amine catabolic process (GO:0009310)2.47766490
163cellular biogenic amine catabolic process (GO:0042402)2.47766490
164eye photoreceptor cell differentiation (GO:0001754)2.47602398
165photoreceptor cell differentiation (GO:0046530)2.47602398
166spermatid nucleus differentiation (GO:0007289)2.47289350
167rhodopsin mediated signaling pathway (GO:0016056)2.45866105
168fat-soluble vitamin catabolic process (GO:0042363)2.45380654
169vitamin catabolic process (GO:0009111)2.45380654
170anterograde synaptic vesicle transport (GO:0048490)2.45006914
171arginine metabolic process (GO:0006525)2.43923101
172mitochondrion degradation (GO:0000422)2.41619073
173platelet dense granule organization (GO:0060155)2.39083254
174amyloid precursor protein catabolic process (GO:0042987)2.37461749
175multicellular organismal development (GO:0007275)2.37115947
176protein K11-linked deubiquitination (GO:0035871)2.36973305
177ether metabolic process (GO:0018904)2.33363316
178monoubiquitinated protein deubiquitination (GO:0035520)2.33092568
179cellular hyperosmotic response (GO:0071474)2.31242054
180microtubule-based movement (GO:0007018)2.30510891
181GPI anchor biosynthetic process (GO:0006506)2.30047176
182protein ADP-ribosylation (GO:0006471)2.29887468
183DNA alkylation (GO:0006305)2.29310490
184DNA methylation (GO:0006306)2.29310490
185antigen processing and presentation via MHC class Ib (GO:0002475)2.28572896
186response to methylmercury (GO:0051597)2.28163425
187regulation of cytokine production involved in inflammatory response (GO:1900015)2.25636443
188cilium or flagellum-dependent cell motility (GO:0001539)12.5414040
189piRNA metabolic process (GO:0034587)10.1195782

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.51680464
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.32383541
3EZH2_22144423_ChIP-Seq_EOC_Human3.36025714
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.99257348
5ZNF274_21170338_ChIP-Seq_K562_Hela2.84857545
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.77620442
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.46032159
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39367775
9IGF1R_20145208_ChIP-Seq_DFB_Human2.36797700
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32304394
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17158098
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.14309594
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13295105
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13278377
15FUS_26573619_Chip-Seq_HEK293_Human2.04377995
16MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.01944644
17VDR_22108803_ChIP-Seq_LS180_Human2.01310363
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00396306
19P300_19829295_ChIP-Seq_ESCs_Human1.99261848
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.95623253
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92542054
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91703736
23GATA1_26923725_Chip-Seq_HPCs_Mouse1.88671008
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.88359514
25ELK1_19687146_ChIP-ChIP_HELA_Human1.87730706
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82862804
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.82675809
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82396004
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79612207
30SCL_19346495_ChIP-Seq_HPC-7_Human1.75127886
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.72464504
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.69146356
33GBX2_23144817_ChIP-Seq_PC3_Human1.62975209
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.58599823
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.57626323
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56254890
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55565275
38* TAL1_26923725_Chip-Seq_HPCs_Mouse1.53842980
39TAF15_26573619_Chip-Seq_HEK293_Human1.53301917
40ER_23166858_ChIP-Seq_MCF-7_Human1.52978046
41SOX2_19829295_ChIP-Seq_ESCs_Human1.50385551
42NANOG_19829295_ChIP-Seq_ESCs_Human1.50385551
43STAT1_20625510_ChIP-Seq_HELA_Human1.47325439
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47034975
45EWS_26573619_Chip-Seq_HEK293_Human1.46108306
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45398389
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44495338
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44219355
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43131081
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.42861788
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.42468639
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42468639
53* PIAS1_25552417_ChIP-Seq_VCAP_Human1.41961282
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41492511
55* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39171452
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37998450
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37972354
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37643471
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.37493925
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37380400
61IRF1_19129219_ChIP-ChIP_H3396_Human1.34458486
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.34033516
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33153437
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29927843
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28977680
66TP53_22573176_ChIP-Seq_HFKS_Human1.28660276
67AR_20517297_ChIP-Seq_VCAP_Human1.28301788
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27460567
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27133337
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26316557
71GATA3_21867929_ChIP-Seq_CD8_Mouse1.26212078
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26191529
73FOXP3_21729870_ChIP-Seq_TREG_Human1.25070803
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24708256
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24627341
76BP1_19119308_ChIP-ChIP_Hs578T_Human1.23530278
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23482278
78KAP1_22055183_ChIP-Seq_ESCs_Mouse1.22906635
79CDX2_22108803_ChIP-Seq_LS180_Human1.22770771
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22546911
81SMAD4_21799915_ChIP-Seq_A2780_Human1.21894255
82* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21634811
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21282218
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21256867
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20652064
86CBP_20019798_ChIP-Seq_JUKART_Human1.20652064
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19870842
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19518949
89PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17933059
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.17734797
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17293761
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15752397
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15640362
94STAT1_17558387_ChIP-Seq_HELA_Human1.14281689
95BCAT_22108803_ChIP-Seq_LS180_Human1.14003411
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13095061
97NANOG_20526341_ChIP-Seq_ESCs_Human1.12672178
98SPI1_23547873_ChIP-Seq_NB4_Human1.12425393
99* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12394091
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12065052
101TCF4_22108803_ChIP-Seq_LS180_Human1.08820385
102* ERG_20517297_ChIP-Seq_VCAP_Human1.08681596
103SOX2_22085726_ChIP-Seq_NPCs_Mouse1.08399021
104CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08158805
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07381046
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06616861
107GATA3_21878914_ChIP-Seq_MCF-7_Human1.05858580
108* TCF4_23295773_ChIP-Seq_U87_Human1.05679215
109HTT_18923047_ChIP-ChIP_STHdh_Human1.05584527
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05003554
111MYC_18940864_ChIP-ChIP_HL60_Human1.04730729
112MYB_26560356_Chip-Seq_TH2_Human1.04242705
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.03551784
114* AR_25329375_ChIP-Seq_VCAP_Human1.03463477
115HOXB7_26014856_ChIP-Seq_BT474_Human1.03236120
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02330276
117* STAT3_23295773_ChIP-Seq_U87_Human1.02117310
118* CBP_21632823_ChIP-Seq_H3396_Human1.01647027
119* SMAD3_21741376_ChIP-Seq_EPCs_Human1.01526765
120NCOR_22424771_ChIP-Seq_293T_Human1.01469300
121ELK1_22589737_ChIP-Seq_MCF10A_Human1.01420318
122YY1_22570637_ChIP-Seq_MALME-3M_Human1.01367759
123VDR_23849224_ChIP-Seq_CD4+_Human1.01288659
124ETS1_22383799_ChIP-Seq_G1ME_Mouse1.01124679
125LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00536010
126CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00055351
127EST1_17652178_ChIP-ChIP_JURKAT_Human0.99705869
128IRF8_27001747_Chip-Seq_BMDM_Mouse0.99626264
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99414373
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99407049
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99161182
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99161182
133POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99068971
134PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98929243
135STAT3_18555785_Chip-Seq_ESCs_Mouse0.98293200
136SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97494271
137PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97081532
138MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96879187
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.96741897
140STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96615066
141CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96475140
142E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96081627
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96059339
144AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96051218
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95953087
146LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95061815
147P53_21459846_ChIP-Seq_SAOS-2_Human0.95054012
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94989850
149GATA3_26560356_Chip-Seq_TH2_Human0.94901623
150GATA3_27048872_Chip-Seq_THYMUS_Human0.94085784
151CRX_20693478_ChIP-Seq_RETINA_Mouse0.93987835
152NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93971034
153GF1_26923725_Chip-Seq_HPCs_Mouse0.93000984
154SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91392040
155GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91359385
156* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90887441
157FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90874650
158RUNX1_26923725_Chip-Seq_HPCs_Mouse0.89843139
159BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89123475
160GATA3_21867929_ChIP-Seq_TH1_Mouse0.88794087
161RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88661212
162SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88133791
163MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87991265
164EZH2_27294783_Chip-Seq_NPCs_Mouse0.86544905
165SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.86497746
166CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85968237
167OCT4_20526341_ChIP-Seq_ESCs_Human0.85350746
168CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85197847
169GATA3_26560356_Chip-Seq_TH1_Human0.84603709
170RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84359463
171SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82436159
172MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.82397767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.44438672
2MP0002138_abnormal_hepatobiliary_system4.94354472
3MP0008877_abnormal_DNA_methylation4.74920400
4MP0001929_abnormal_gametogenesis3.96057820
5MP0003136_yellow_coat_color3.85959816
6MP0003698_abnormal_male_reproductive3.85452671
7MP0002139_abnormal_hepatobiliary_system3.11894921
8MP0002210_abnormal_sex_determination2.97261286
9MP0003183_abnormal_peptide_metabolism2.82817320
10MP0000569_abnormal_digit_pigmentation2.80993240
11MP0003186_abnormal_redox_activity2.80673527
12MP0001145_abnormal_male_reproductive2.33425377
13MP0001835_abnormal_antigen_presentation2.20919382
14MP0000685_abnormal_immune_system2.14556965
15MP0000653_abnormal_sex_gland2.10528618
16MP0002161_abnormal_fertility/fecundity2.03471646
17MP0005365_abnormal_bile_salt2.03194093
18MP0005671_abnormal_response_to2.02115569
19MP0003195_calcinosis2.01921505
20MP0000920_abnormal_myelination2.00671617
21MP0001984_abnormal_olfaction1.95860848
22MP0005084_abnormal_gallbladder_morpholo1.95543224
23MP0005085_abnormal_gallbladder_physiolo1.93323796
24MP0005379_endocrine/exocrine_gland_phen1.89335802
25MP0002653_abnormal_ependyma_morphology1.88685255
26MP0001986_abnormal_taste_sensitivity1.85921794
27MP0008057_abnormal_DNA_replication1.85540335
28MP0002876_abnormal_thyroid_physiology1.85099084
29MP0008875_abnormal_xenobiotic_pharmacok1.83700280
30MP0005332_abnormal_amino_acid1.77035218
31MP0002638_abnormal_pupillary_reflex1.76956589
32MP0005408_hypopigmentation1.71280946
33MP0006054_spinal_hemorrhage1.70536815
34MP0003252_abnormal_bile_duct1.67922038
35MP0006035_abnormal_mitochondrial_morpho1.63626489
36MP0005171_absent_coat_pigmentation1.61415374
37MP0004147_increased_porphyrin_level1.57364900
38MP0008058_abnormal_DNA_repair1.56897231
39MP0000749_muscle_degeneration1.53989133
40MP0003718_maternal_effect1.50366719
41MP0002160_abnormal_reproductive_system1.47225139
42MP0002102_abnormal_ear_morphology1.45646432
43MP0003890_abnormal_embryonic-extraembry1.43710178
44MP0002148_abnormal_hypersensitivity_rea1.43394960
45MP0000372_irregular_coat_pigmentation1.43364457
46MP0005075_abnormal_melanosome_morpholog1.43346417
47MP0005646_abnormal_pituitary_gland1.41960132
48MP0008007_abnormal_cellular_replicative1.40031184
49MP0004145_abnormal_muscle_electrophysio1.31728763
50MP0005409_darkened_coat_color1.31635048
51MP0001348_abnormal_lacrimal_gland1.30464961
52MP0009785_altered_susceptibility_to1.24463956
53MP0003763_abnormal_thymus_physiology1.24253152
54MP0004134_abnormal_chest_morphology1.23975380
55MP0002269_muscular_atrophy1.23968176
56MP0002254_reproductive_system_inflammat1.23080965
57MP0008004_abnormal_stomach_pH1.23040870
58MP0008872_abnormal_physiological_respon1.22345589
59MP0004381_abnormal_hair_follicle1.21228663
60MP0000427_abnormal_hair_cycle1.17566709
61MP0004036_abnormal_muscle_relaxation1.17308937
62MP0000013_abnormal_adipose_tissue1.17203290
63MP0001661_extended_life_span1.16926921
64MP0006072_abnormal_retinal_apoptosis1.15521509
65MP0005464_abnormal_platelet_physiology1.15255743
66MP0004808_abnormal_hematopoietic_stem1.14563779
67MP0004215_abnormal_myocardial_fiber1.14450663
68MP0003646_muscle_fatigue1.12744537
69MP0005670_abnormal_white_adipose1.11713176
70MP0002693_abnormal_pancreas_physiology1.10813557
71MP0003806_abnormal_nucleotide_metabolis1.10240691
72MP0002909_abnormal_adrenal_gland1.10074602
73MP0005174_abnormal_tail_pigmentation1.10033212
74MP0006292_abnormal_olfactory_placode1.08950668
75MP0005310_abnormal_salivary_gland1.07996587
76MP0002405_respiratory_system_inflammati1.07959428
77MP0005025_abnormal_response_to1.07404011
78MP0003786_premature_aging1.05051724
79MP0005330_cardiomyopathy1.04914035
80MP0006036_abnormal_mitochondrial_physio1.04572506
81MP0006082_CNS_inflammation1.04297909
82MP0002723_abnormal_immune_serum1.03857884
83MP0009697_abnormal_copulation1.03714163
84MP0004142_abnormal_muscle_tone1.02385700
85MP0001756_abnormal_urination1.02227661
86MP0004019_abnormal_vitamin_homeostasis1.01529369
87MP0005000_abnormal_immune_tolerance1.01399309
88MP0010386_abnormal_urinary_bladder1.01352312
89MP0010329_abnormal_lipoprotein_level1.00745983
90MP0002837_dystrophic_cardiac_calcinosis0.99667146
91MP0005387_immune_system_phenotype0.98636504
92MP0001790_abnormal_immune_system0.98636504
93MP0001905_abnormal_dopamine_level0.97694244
94MP0003950_abnormal_plasma_membrane0.96975600
95MP0002009_preneoplasia0.95505524
96MP0005266_abnormal_metabolism0.95431524
97MP0009780_abnormal_chondrocyte_physiolo0.92423318
98MP0002420_abnormal_adaptive_immunity0.91508339
99MP0008775_abnormal_heart_ventricle0.91082703
100MP0008995_early_reproductive_senescence0.90904048
101MP0009046_muscle_twitch0.89930838
102MP0001819_abnormal_immune_cell0.89565752
103MP0003121_genomic_imprinting0.89334674
104MP0000465_gastrointestinal_hemorrhage0.86430753
105MP0001800_abnormal_humoral_immune0.86196217
106MP0002398_abnormal_bone_marrow0.86193545
107MP0005623_abnormal_meninges_morphology0.84259417
108MP0002452_abnormal_antigen_presenting0.83359497
109MP0002090_abnormal_vision0.83208449
110MP0000716_abnormal_immune_system0.83203040
111MP0009643_abnormal_urine_homeostasis0.83160950
112MP0002938_white_spotting0.82962684
113MP0002419_abnormal_innate_immunity0.82044488
114MP0005058_abnormal_lysosome_morphology0.81896177
115MP0005319_abnormal_enzyme/_coenzyme0.81235394
116MP0005253_abnormal_eye_physiology0.80717304
117MP0001853_heart_inflammation0.80310960
118MP0003011_delayed_dark_adaptation0.80177222
119MP0003943_abnormal_hepatobiliary_system0.80132329
120MP0005397_hematopoietic_system_phenotyp0.79726043
121MP0001545_abnormal_hematopoietic_system0.79726043
122MP0004043_abnormal_pH_regulation0.79158290
123MP0005645_abnormal_hypothalamus_physiol0.77466082
124MP0000230_abnormal_systemic_arterial0.77188577
125MP0005647_abnormal_sex_gland0.77069848
126MP0002078_abnormal_glucose_homeostasis0.76608833
127MP0000689_abnormal_spleen_morphology0.75932234
128MP0002282_abnormal_trachea_morphology0.75244136
129MP0001765_abnormal_ion_homeostasis0.75157996
130MP0003137_abnormal_impulse_conducting0.74574486
131MP0005389_reproductive_system_phenotype0.73174375
132MP0002396_abnormal_hematopoietic_system0.73106471
133MP0000516_abnormal_urinary_system0.73082480
134MP0005367_renal/urinary_system_phenotyp0.73082480
135MP0002295_abnormal_pulmonary_circulatio0.72885848
136MP0002163_abnormal_gland_morphology0.72513503
137MP0005220_abnormal_exocrine_pancreas0.72216095
138MP0002118_abnormal_lipid_homeostasis0.71851635
139MP0002095_abnormal_skin_pigmentation0.70269516
140MP0005636_abnormal_mineral_homeostasis0.70187763
141MP0002429_abnormal_blood_cell0.70012162
142MP0000462_abnormal_digestive_system0.68810340
143MP0005551_abnormal_eye_electrophysiolog0.68335887
144MP0000358_abnormal_cell_content/0.67768398
145MP0000647_abnormal_sebaceous_gland0.67706396
146MP0000678_abnormal_parathyroid_gland0.67561709
147MP0000015_abnormal_ear_pigmentation0.67300988
148MP0002132_abnormal_respiratory_system0.67108045
149MP0001851_eye_inflammation0.65812022
150MP0001764_abnormal_homeostasis0.65543549
151MP0004084_abnormal_cardiac_muscle0.65539564
152MP0000343_altered_response_to0.65121616
153MP0001542_abnormal_bone_strength0.64767465
154MP0001324_abnormal_eye_pigmentation0.64331795
155MP0001968_abnormal_touch/_nociception0.64285536
156MP0009278_abnormal_bone_marrow0.63325372
157MP0010094_abnormal_chromosome_stability0.62270488
158MP0005535_abnormal_body_temperature0.61258361
159MP0001666_abnormal_nutrient_absorption0.60947135
160MP0001944_abnormal_pancreas_morphology0.60461883
161MP0005395_other_phenotype0.60200212
162MP0005360_urolithiasis0.59475033

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.62581712
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.38752521
3Absent/shortened dynein arms (HP:0200106)8.38752521
4Abnormal respiratory motile cilium physiology (HP:0012261)6.72924515
5Abnormal respiratory motile cilium morphology (HP:0005938)6.62230317
6Abnormal respiratory epithelium morphology (HP:0012253)6.62230317
7Rhinitis (HP:0012384)6.02405721
8Abnormal ciliary motility (HP:0012262)5.51080660
9Chronic bronchitis (HP:0004469)4.83753500
10Nasal polyposis (HP:0100582)4.76482184
11Infertility (HP:0000789)4.01835293
12Abnormality of the nasal mucosa (HP:0000433)3.95844352
13Acute necrotizing encephalopathy (HP:0006965)3.87136769
14Bronchiectasis (HP:0002110)3.82600902
15Nephronophthisis (HP:0000090)3.79723213
16Bronchitis (HP:0012387)3.73644136
17Acute encephalopathy (HP:0006846)3.59865442
18Abnormal hair whorl (HP:0010721)3.41880840
19Abnormal mitochondria in muscle tissue (HP:0008316)3.41204134
20Methylmalonic acidemia (HP:0002912)3.40587855
21Progressive macrocephaly (HP:0004481)3.40192985
22Gonadotropin excess (HP:0000837)3.35628213
23Mitochondrial inheritance (HP:0001427)3.31936843
24Increased CSF lactate (HP:0002490)3.21040168
25Abnormality of aromatic amino acid family metabolism (HP:0004338)3.08939369
26Hepatic necrosis (HP:0002605)3.08717146
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.07988130
28Type I transferrin isoform profile (HP:0003642)3.06741237
29Recurrent bronchitis (HP:0002837)3.00237893
30Medial flaring of the eyebrow (HP:0010747)2.95593278
31Congenital, generalized hypertrichosis (HP:0004540)2.95226384
32Fair hair (HP:0002286)2.92595087
33Abnormality of the renal medulla (HP:0100957)2.91047353
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.90713671
35Hepatocellular necrosis (HP:0001404)2.89441175
36Abnormal protein glycosylation (HP:0012346)2.89058491
37Abnormal glycosylation (HP:0012345)2.89058491
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.89058491
39Abnormal protein N-linked glycosylation (HP:0012347)2.89058491
40Cerebral edema (HP:0002181)2.68245923
41Methylmalonic aciduria (HP:0012120)2.68006403
42Amelogenesis imperfecta (HP:0000705)2.67864830
43Testicular atrophy (HP:0000029)2.66615398
44Increased hepatocellular lipid droplets (HP:0006565)2.64068640
45Retinal dysplasia (HP:0007973)2.60466857
46Recurrent sinusitis (HP:0011108)2.56682229
47J-shaped sella turcica (HP:0002680)2.56303159
48Tubulointerstitial nephritis (HP:0001970)2.55498245
49Myoglobinuria (HP:0002913)2.54508082
50Cerebellar dysplasia (HP:0007033)2.52242225
513-Methylglutaconic aciduria (HP:0003535)2.52086218
52Recurrent otitis media (HP:0000403)2.45241086
53Lipid accumulation in hepatocytes (HP:0006561)2.43225123
54Abnormality of vitamin B metabolism (HP:0004340)2.42203718
55Congenital stationary night blindness (HP:0007642)2.41386671
56Chronic sinusitis (HP:0011109)2.40881121
57Ketoacidosis (HP:0001993)2.40244127
5811 pairs of ribs (HP:0000878)2.39342970
59Abnormality of the anterior horn cell (HP:0006802)2.38722948
60Degeneration of anterior horn cells (HP:0002398)2.38722948
61Decreased central vision (HP:0007663)2.34690314
62Lactic acidosis (HP:0003128)2.31861493
63Abnormal biliary tract physiology (HP:0012439)2.30615885
64Bile duct proliferation (HP:0001408)2.30615885
65Renal Fanconi syndrome (HP:0001994)2.30374683
66Abnormality of midbrain morphology (HP:0002418)2.28368817
67Molar tooth sign on MRI (HP:0002419)2.28368817
68Abnormality of the labia minora (HP:0012880)2.26976327
69Postaxial foot polydactyly (HP:0001830)2.26622051
70Hypoglycemic coma (HP:0001325)2.26315388
71Fibular hypoplasia (HP:0003038)2.23113330
72Pancreatic fibrosis (HP:0100732)2.22784911
73Vacuolated lymphocytes (HP:0001922)2.22540531
74Type II lissencephaly (HP:0007260)2.21097847
75Abnormality of urine glucose concentration (HP:0011016)2.20966748
76Glycosuria (HP:0003076)2.20966748
77Abnormality of serum amino acid levels (HP:0003112)2.19162371
78Ketosis (HP:0001946)2.18981619
79Posterior subcapsular cataract (HP:0007787)2.18576601
80Congenital hepatic fibrosis (HP:0002612)2.18563720
81Chronic otitis media (HP:0000389)2.17936139
82Proximal tubulopathy (HP:0000114)2.16851340
83Abnormal spermatogenesis (HP:0008669)2.16572250
84Respiratory failure (HP:0002878)2.16341064
85Reduced antithrombin III activity (HP:0001976)2.16041234
86Progressive inability to walk (HP:0002505)2.14023114
87Increased corneal curvature (HP:0100692)2.13980316
88Keratoconus (HP:0000563)2.13980316
89Palpitations (HP:0001962)2.13759898
90Hyperglycinuria (HP:0003108)2.13337225
91Optic disc pallor (HP:0000543)2.12098277
92Focal motor seizures (HP:0011153)2.10477842
93Tubulointerstitial abnormality (HP:0001969)2.10106313
94Polydipsia (HP:0001959)2.07946880
95Abnormal drinking behavior (HP:0030082)2.07946880
96Generalized hypopigmentation of hair (HP:0011358)2.07678163
97Lethargy (HP:0001254)2.07524371
98Cerebral palsy (HP:0100021)2.06982788
99Abnormality of renal resorption (HP:0011038)2.06228707
100Abnormality of methionine metabolism (HP:0010901)2.03402613
101Abnormality of the dental root (HP:0006486)2.02751244
102Taurodontia (HP:0000679)2.02751244
103Abnormality of permanent molar morphology (HP:0011071)2.02751244
104Dry hair (HP:0011359)2.01607367
105Hypothermia (HP:0002045)2.01086555
106Abnormality of the dental pulp (HP:0006479)1.99650740
107Aplastic anemia (HP:0001915)1.99106536
108Abnormality of molar morphology (HP:0011070)1.98688038
109Abnormality of molar (HP:0011077)1.98688038
110Arthropathy (HP:0003040)1.98321938
111Abnormality of vitamin metabolism (HP:0100508)1.97566709
112Aplasia/Hypoplasia of the tongue (HP:0010295)1.97534439
113Severe visual impairment (HP:0001141)1.97448798
114Prostate neoplasm (HP:0100787)1.97381220
115True hermaphroditism (HP:0010459)1.96865913
116Abnormality of the renal cortex (HP:0011035)1.96851854
117Short thorax (HP:0010306)1.96731147
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.96384453
119Abnormality of the vitamin B12 metabolism (HP:0004341)1.95938162
120Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93665923
121Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93665923
122Increased serum lactate (HP:0002151)1.92689091
123Central scotoma (HP:0000603)1.92458787
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90970753
125Abnormality of serine family amino acid metabolism (HP:0010894)1.87990104
126Abnormality of glycine metabolism (HP:0010895)1.87990104
127Abnormality of dentin (HP:0010299)1.87224483
128Congenital primary aphakia (HP:0007707)1.86415839
129Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85601345
130Neoplasm of the adrenal gland (HP:0100631)1.84748096
131Cystic liver disease (HP:0006706)1.84372275
132Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84256845
133Pancytopenia (HP:0001876)1.83892576
134Hypokinesia (HP:0002375)1.83783438
135Supernumerary spleens (HP:0009799)1.83606293
136Generalized aminoaciduria (HP:0002909)1.83324547
137Hyperphosphaturia (HP:0003109)1.82522931
138Colon cancer (HP:0003003)1.82118845
139Inability to walk (HP:0002540)1.80358975
140Nephropathy (HP:0000112)1.76389941
141Degeneration of the lateral corticospinal tracts (HP:0002314)1.76060746
142Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76060746
143Tubular atrophy (HP:0000092)1.74464758
144Hypoglycemic seizures (HP:0002173)1.74458815
145Gait imbalance (HP:0002141)1.74307515
146Dicarboxylic aciduria (HP:0003215)1.72156894
147Upper motor neuron abnormality (HP:0002127)1.69871154
148Stage 5 chronic kidney disease (HP:0003774)1.69805844
149Impaired proprioception (HP:0010831)1.69709828
150Amyotrophic lateral sclerosis (HP:0007354)1.67448400
151Nephrogenic diabetes insipidus (HP:0009806)1.67052162
152Patchy hypopigmentation of hair (HP:0011365)1.65339980
153Abolished electroretinogram (ERG) (HP:0000550)1.64186068
154Hyperinsulinemic hypoglycemia (HP:0000825)1.63612472
155Postaxial hand polydactyly (HP:0001162)1.62139369
156Hyperphosphatemia (HP:0002905)1.61719857
157Neurofibrillary tangles (HP:0002185)1.61558927
158Aplasia/Hypoplasia of the lens (HP:0008063)1.59720904
159Tubulointerstitial fibrosis (HP:0005576)1.59398081
160Abnormal rod and cone electroretinograms (HP:0008323)1.59060770
161Median cleft lip (HP:0000161)1.58754597
162Weak cry (HP:0001612)1.58453773
163Bell-shaped thorax (HP:0001591)1.58334473
164Nonprogressive disorder (HP:0003680)1.55116896
165Type 2 muscle fiber atrophy (HP:0003554)1.52171025
166Azoospermia (HP:0000027)1.51944814
167Aplasia/Hypoplasia of the fovea (HP:0008060)1.50224025
168Hypoplasia of the fovea (HP:0007750)1.50224025
169Deformed sella turcica (HP:0002681)1.48239053
170Anencephaly (HP:0002323)1.47874400
171White forelock (HP:0002211)1.46444377
172Pancreatic cysts (HP:0001737)1.46150089
173Retinitis pigmentosa (HP:0000510)1.46091765
174Facial cleft (HP:0002006)1.46014469
175Loss of speech (HP:0002371)1.44822524

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.97311023
2PDK45.97311023
3STK38L4.54896562
4FRK3.95668934
5PDK23.62572685
6LATS13.46562721
7MAPK153.41890380
8TESK12.91127258
9STK392.84308626
10MST42.74106171
11WNK42.63639357
12NUAK12.50194228
13ICK2.33374117
14PRKD32.32591975
15STK32.31920225
16EIF2AK12.13388397
17VRK22.02072034
18MAP4K21.98043301
19TNIK1.97035046
20PASK1.95855750
21PIK3CG1.89092359
22STK161.84398357
23BMPR1B1.83156174
24ACVR1B1.81546272
25PINK11.80657083
26KIT1.74761377
27MUSK1.72789005
28MAPKAPK51.66642667
29MAP3K121.66037086
30FLT31.62369445
31MAP4K11.60686734
32GRK11.57107333
33MKNK21.49927432
34DYRK31.34662954
35NME11.32669763
36DYRK1B1.31484281
37CSF1R1.29379764
38CDK81.27468125
39PTK2B1.25997349
40PLK21.22736476
41TEC1.19785152
42TAOK31.17172722
43EIF2AK31.15868192
44CCNB11.13695432
45PLK31.12053851
46PBK1.11944659
47BTK1.08017956
48OBSCN1.03959153
49LATS21.03388795
50PRKCE1.03218839
51IKBKE1.01013218
52VRK11.00529144
53TBK10.97752782
54NEK10.97064772
55PLK10.96750565
56INSRR0.95697566
57MKNK10.95444222
58NLK0.94523372
59TTK0.92465139
60STK40.92048566
61IRAK10.91988100
62LIMK10.91391555
63CSNK1G10.89552297
64ADRBK10.87770325
65CLK10.87334253
66TXK0.87203172
67CSNK1G20.87172772
68WNK10.86698493
69NEK60.82964598
70ZAP700.82300047
71MAP2K60.81271640
72EPHB10.79880492
73PAK30.79183681
74DMPK0.78637383
75TIE10.78306463
76TRIM280.77783677
77CDK190.77745969
78BMPR20.76053782
79CSNK1G30.75838127
80TLK10.75161307
81WNK30.75132529
82PKN10.71641508
83BUB10.70327524
84IKBKB0.69548067
85ATR0.67790750
86BCKDK0.67214419
87HIPK20.66038225
88NEK20.63871616
89TESK20.63836278
90STK380.63566152
91DYRK20.63268743
92ADRBK20.62780207
93FER0.61318473
94SIK30.58392207
95GRK50.57263103
96CAMK2D0.55917615
97IRAK40.53399733
98GRK70.53372574
99DAPK10.52681490
100EPHA30.52479430
101JAK30.51781334
102PRKCQ0.51686283
103BRAF0.50928514
104OXSR10.49389239
105PRKCG0.49355483
106PRKCI0.49171724
107TYK20.48330032
108ATM0.48313776
109MAP2K30.48041001
110STK240.47599676
111PHKG20.46690314
112PHKG10.46690314
113TRPM70.46541465
114PDK10.44899376
115CDK70.44531142
116DAPK20.44305057
117CSNK1A10.43159933
118RPS6KA50.43028630
119PRKAA20.42649438
120PNCK0.42441075
121BRD40.42163078
122WEE10.41172560
123MOS0.40687705
124ILK0.40592893
125ERBB40.40284852
126ZAK0.40051150
127LCK0.39904309
128ARAF0.39559535
129PLK40.37755591
130MARK30.37690309
131CSNK1A1L0.37686377
132MAPK130.37120121
133MAP3K140.36822206
134MAPKAPK30.36593811
135ABL20.35937440
136MAP3K60.35118188
137UHMK10.34999051
138CSNK2A20.34093358
139CDC70.34062848
140PRKACA0.33171765
141LYN0.32879311
142KDR0.32856118
143SYK0.32800552
144STK100.32069533
145SRPK10.32014362
146PIM20.31774779
147NEK90.31454757
148AKT20.31418182
149TGFBR20.31131754
150ABL10.30346469
151PRKD20.29405103
152MINK10.28864658
153MYLK0.28843694
154CAMK2A0.28390080
155BRSK20.28186531
156TNK20.28080469
157ERBB30.27823995
158CDK30.27793361
159DAPK30.27783285
160YES10.27778197
161ITK0.27546917
162MET0.26482895
163MARK20.26161252
164TGFBR10.24592797
165PRKG10.24489627

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.42490155
2Basal transcription factors_Homo sapiens_hsa030223.00026146
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72838479
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.68778164
5Butanoate metabolism_Homo sapiens_hsa006502.43129984
6Fanconi anemia pathway_Homo sapiens_hsa034602.30456673
7Fatty acid elongation_Homo sapiens_hsa000622.25552701
8Phototransduction_Homo sapiens_hsa047442.23699796
9Mismatch repair_Homo sapiens_hsa034302.12196479
10N-Glycan biosynthesis_Homo sapiens_hsa005102.10961225
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09549917
12DNA replication_Homo sapiens_hsa030302.09263609
13Other glycan degradation_Homo sapiens_hsa005111.94202634
14Ether lipid metabolism_Homo sapiens_hsa005651.94088554
15Sulfur metabolism_Homo sapiens_hsa009201.93506527
16Folate biosynthesis_Homo sapiens_hsa007901.90298322
17Homologous recombination_Homo sapiens_hsa034401.89726631
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.88751384
19Selenocompound metabolism_Homo sapiens_hsa004501.88480972
20Propanoate metabolism_Homo sapiens_hsa006401.88212167
21Pyruvate metabolism_Homo sapiens_hsa006201.85189085
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.84337988
23Linoleic acid metabolism_Homo sapiens_hsa005911.82079901
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79674763
25Base excision repair_Homo sapiens_hsa034101.79075077
26Tryptophan metabolism_Homo sapiens_hsa003801.68226433
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.67976651
28Caffeine metabolism_Homo sapiens_hsa002321.61159878
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.58747057
30Non-homologous end-joining_Homo sapiens_hsa034501.57051293
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.53859756
32Huntingtons disease_Homo sapiens_hsa050161.53530970
33Vitamin B6 metabolism_Homo sapiens_hsa007501.51218892
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47744785
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46794241
36Pentose phosphate pathway_Homo sapiens_hsa000301.46785994
37One carbon pool by folate_Homo sapiens_hsa006701.46739288
38Sphingolipid metabolism_Homo sapiens_hsa006001.45019588
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43639265
40beta-Alanine metabolism_Homo sapiens_hsa004101.42702640
41Nucleotide excision repair_Homo sapiens_hsa034201.39401287
42Purine metabolism_Homo sapiens_hsa002301.37098693
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36748265
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35931392
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34301814
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.32207169
47Chemical carcinogenesis_Homo sapiens_hsa052041.31514363
48RNA degradation_Homo sapiens_hsa030181.31431651
49Pyrimidine metabolism_Homo sapiens_hsa002401.25338999
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22159631
51Arachidonic acid metabolism_Homo sapiens_hsa005901.20169376
52ABC transporters_Homo sapiens_hsa020101.19854503
53RNA polymerase_Homo sapiens_hsa030201.15081865
54Primary immunodeficiency_Homo sapiens_hsa053401.15008186
55Oxidative phosphorylation_Homo sapiens_hsa001901.13952404
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11148175
57Antigen processing and presentation_Homo sapiens_hsa046121.03000377
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.02125098
59Histidine metabolism_Homo sapiens_hsa003400.99481823
60Allograft rejection_Homo sapiens_hsa053300.99164954
61Parkinsons disease_Homo sapiens_hsa050120.97088511
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96210206
63Peroxisome_Homo sapiens_hsa041460.95438611
64Phenylalanine metabolism_Homo sapiens_hsa003600.89502105
65Arginine and proline metabolism_Homo sapiens_hsa003300.88112608
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87025520
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85955048
68Nitrogen metabolism_Homo sapiens_hsa009100.85391460
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85028757
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84233398
71Proteasome_Homo sapiens_hsa030500.83658533
72Lysosome_Homo sapiens_hsa041420.82132747
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82089321
74Collecting duct acid secretion_Homo sapiens_hsa049660.81198889
75Measles_Homo sapiens_hsa051620.80494101
76Steroid biosynthesis_Homo sapiens_hsa001000.79742451
77Alzheimers disease_Homo sapiens_hsa050100.79257687
78Glucagon signaling pathway_Homo sapiens_hsa049220.78746901
79Sulfur relay system_Homo sapiens_hsa041220.78137192
80B cell receptor signaling pathway_Homo sapiens_hsa046620.77949187
81Metabolic pathways_Homo sapiens_hsa011000.75968992
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72652224
83Fatty acid metabolism_Homo sapiens_hsa012120.71550412
84Glutathione metabolism_Homo sapiens_hsa004800.70878717
85Tyrosine metabolism_Homo sapiens_hsa003500.70583461
86Fructose and mannose metabolism_Homo sapiens_hsa000510.68946959
87Starch and sucrose metabolism_Homo sapiens_hsa005000.67077784
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.65414605
89Fatty acid biosynthesis_Homo sapiens_hsa000610.64639385
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64028213
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63464907
92Legionellosis_Homo sapiens_hsa051340.63409442
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60863677
94Hematopoietic cell lineage_Homo sapiens_hsa046400.60498036
95Spliceosome_Homo sapiens_hsa030400.59569447
96Vibrio cholerae infection_Homo sapiens_hsa051100.59472493
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56768117
98RNA transport_Homo sapiens_hsa030130.56572856
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56292907
100Malaria_Homo sapiens_hsa051440.55848951
101Herpes simplex infection_Homo sapiens_hsa051680.54726910
102Dorso-ventral axis formation_Homo sapiens_hsa043200.53986971
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.53599388
104Fatty acid degradation_Homo sapiens_hsa000710.52706268
105Circadian rhythm_Homo sapiens_hsa047100.52399788
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.50587097
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49934039
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48528773
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47748566
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47437959
111Ribosome_Homo sapiens_hsa030100.45792527
112Cardiac muscle contraction_Homo sapiens_hsa042600.45779752
113Cell cycle_Homo sapiens_hsa041100.44527897
114mRNA surveillance pathway_Homo sapiens_hsa030150.44450824
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44256108
116PPAR signaling pathway_Homo sapiens_hsa033200.41683315
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41427396
118Retinol metabolism_Homo sapiens_hsa008300.40720075
119Asthma_Homo sapiens_hsa053100.40439968
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40116496
121Vitamin digestion and absorption_Homo sapiens_hsa049770.39652459
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.37387311
123Fat digestion and absorption_Homo sapiens_hsa049750.36904152
124Regulation of autophagy_Homo sapiens_hsa041400.35358452
125Type I diabetes mellitus_Homo sapiens_hsa049400.34955215
126Lysine degradation_Homo sapiens_hsa003100.33409980
127Ovarian steroidogenesis_Homo sapiens_hsa049130.33368065
128Galactose metabolism_Homo sapiens_hsa000520.33264301
129Insulin secretion_Homo sapiens_hsa049110.32121777
130Carbon metabolism_Homo sapiens_hsa012000.32118515
131NF-kappa B signaling pathway_Homo sapiens_hsa040640.31509395
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31059473
133Mineral absorption_Homo sapiens_hsa049780.31036394
134Oocyte meiosis_Homo sapiens_hsa041140.27709929
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27137289
136Phagosome_Homo sapiens_hsa041450.26665307
137Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25485789
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25424209
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24936054

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