RNPC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 65K protein that is a component of the U12-type spliceosome. This protein contains two RNA recognition motifs (RRMs), suggesting that it may contact one of the small nuclear RNAs of the minor spliceosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)5.23274059
2detection of light stimulus involved in visual perception (GO:0050908)5.23274059
3retinal rod cell development (GO:0046548)4.72416366
4retinal cone cell development (GO:0046549)4.64576661
5rhodopsin mediated signaling pathway (GO:0016056)4.48429191
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.29718609
7protein-chromophore linkage (GO:0018298)4.28884532
8regulation of rhodopsin mediated signaling pathway (GO:0022400)4.28476971
9mRNA splice site selection (GO:0006376)4.23902737
10G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.16430090
11positive regulation of gamma-delta T cell activation (GO:0046645)4.07085069
12striatum development (GO:0021756)4.06166689
13protein localization to synapse (GO:0035418)4.03904514
14photoreceptor cell development (GO:0042461)4.03263456
15regulation of B cell receptor signaling pathway (GO:0050855)3.99830607
16eye photoreceptor cell development (GO:0042462)3.99592469
17regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.95676824
18positive regulation of granulocyte differentiation (GO:0030854)3.93382756
19synaptic vesicle exocytosis (GO:0016079)3.92761386
20photoreceptor cell maintenance (GO:0045494)3.86752968
21nonmotile primary cilium assembly (GO:0035058)3.83914996
22activated T cell proliferation (GO:0050798)3.83546601
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.79662647
24GMP metabolic process (GO:0046037)3.73639360
25regulation of short-term neuronal synaptic plasticity (GO:0048172)3.73480288
26alternative mRNA splicing, via spliceosome (GO:0000380)3.71663040
27neuron cell-cell adhesion (GO:0007158)3.63351423
28response to histamine (GO:0034776)3.61585083
29presynaptic membrane assembly (GO:0097105)3.58134909
30positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.54831912
31DNA deamination (GO:0045006)3.53784817
32negative T cell selection (GO:0043383)3.52857974
33pyrimidine dimer repair (GO:0006290)3.52844223
34glutamate receptor signaling pathway (GO:0007215)3.52498711
35histone H3-K4 trimethylation (GO:0080182)3.51186446
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.50169869
37negative thymic T cell selection (GO:0045060)3.45949195
38neural tube formation (GO:0001841)3.45275810
39cilium or flagellum-dependent cell motility (GO:0001539)3.44937960
40positive regulation of B cell differentiation (GO:0045579)3.43764034
41regulation of synaptic vesicle exocytosis (GO:2000300)3.41990807
42negative regulation of cytosolic calcium ion concentration (GO:0051481)3.35557131
43ionotropic glutamate receptor signaling pathway (GO:0035235)3.35375501
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.35029187
45neurotransmitter-gated ion channel clustering (GO:0072578)3.31064534
46synaptic vesicle maturation (GO:0016188)3.29577532
47termination of RNA polymerase III transcription (GO:0006386)3.20635127
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.20635127
49interkinetic nuclear migration (GO:0022027)3.19917206
50synaptic transmission, glutamatergic (GO:0035249)3.19785807
51postsynaptic membrane organization (GO:0001941)3.14860146
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.14359480
53atrial cardiac muscle cell action potential (GO:0086014)3.10741907
54regulation of mRNA splicing, via spliceosome (GO:0048024)3.09771786
55startle response (GO:0001964)3.08960962
56regulation of synaptic vesicle transport (GO:1902803)3.07800050
57positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.04762032
58transmission of nerve impulse (GO:0019226)3.04578851
59regulation of gamma-delta T cell differentiation (GO:0045586)3.02940945
60interferon-gamma production (GO:0032609)3.02652054
61viral mRNA export from host cell nucleus (GO:0046784)3.01915195
62cerebellar Purkinje cell differentiation (GO:0021702)3.01766661
63establishment of protein localization to Golgi (GO:0072600)3.01214887
64righting reflex (GO:0060013)3.00726293
65negative regulation of mRNA processing (GO:0050686)2.96804667
66neuron-neuron synaptic transmission (GO:0007270)2.96216067
67response to pheromone (GO:0019236)2.95541713
68regulation of histone H3-K27 methylation (GO:0061085)2.95172943
69peptidyl-lysine trimethylation (GO:0018023)2.94737809
70presynaptic membrane organization (GO:0097090)2.93434486
71regulation of neurotransmitter secretion (GO:0046928)2.93035180
72regulation of gamma-delta T cell activation (GO:0046643)2.92604810
73negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.89729927
74regulation of relaxation of muscle (GO:1901077)2.88693203
75cell wall macromolecule catabolic process (GO:0016998)2.86340204
76regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.86028814
77positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.86028814
78regulation of B cell differentiation (GO:0045577)2.84204409
79epithelial cilium movement (GO:0003351)2.83034104
80B cell receptor signaling pathway (GO:0050853)2.82897114
81positive T cell selection (GO:0043368)2.82835137
82regulation of germinal center formation (GO:0002634)2.82524580
83histone H2A acetylation (GO:0043968)2.81426982
84cellular potassium ion homeostasis (GO:0030007)2.75910595
85protein targeting to Golgi (GO:0000042)2.75531668
86poly(A)+ mRNA export from nucleus (GO:0016973)2.75143228
87neurotransmitter secretion (GO:0007269)2.75114509
88positive regulation of membrane potential (GO:0045838)2.74118831
89positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.74062528
90long-term memory (GO:0007616)2.72552468
91termination of RNA polymerase II transcription (GO:0006369)2.71794588
92microglial cell activation (GO:0001774)2.70309762
93protein localization to cilium (GO:0061512)2.69495209
94DNA topological change (GO:0006265)2.69258672
95regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.68340867
96cilium movement (GO:0003341)2.65255195
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64979759
98regulation of glutamate receptor signaling pathway (GO:1900449)2.64631879
99calcium ion import (GO:0070509)2.64453961
100cell wall macromolecule metabolic process (GO:0044036)2.64235320
101retrograde transport, vesicle recycling within Golgi (GO:0000301)2.63734827
102regulation of neurotransmitter transport (GO:0051588)2.63656313
103regulation of development, heterochronic (GO:0040034)2.63578220
104visual perception (GO:0007601)2.61918290
105sensory perception of light stimulus (GO:0050953)2.61352323
106axoneme assembly (GO:0035082)2.61035800
107dendrite morphogenesis (GO:0048813)2.59834395
108regulation of cilium movement (GO:0003352)2.59293345
109histone H3-K9 modification (GO:0061647)2.58831029
110mast cell activation (GO:0045576)2.57979435
111negative regulation of mRNA metabolic process (GO:1903312)2.57968777
112vocalization behavior (GO:0071625)2.57006207
113negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.56607332
114negative regulation of cell killing (GO:0031342)2.56607332
115neuronal action potential (GO:0019228)2.56599095
116regulation of mRNA processing (GO:0050684)2.55941115
117membrane depolarization during action potential (GO:0086010)2.55517304
118monoubiquitinated protein deubiquitination (GO:0035520)2.55198142
119regulation of pigment cell differentiation (GO:0050932)2.54730765
120membrane hyperpolarization (GO:0060081)2.54036350
121innervation (GO:0060384)2.53662857
122sodium ion export (GO:0071436)2.53236850
123protein K11-linked deubiquitination (GO:0035871)2.52651470
124histone H3-K9 methylation (GO:0051567)2.52398033
125synaptic vesicle endocytosis (GO:0048488)2.51652279
126response to auditory stimulus (GO:0010996)2.51295279
127cellular response to interleukin-15 (GO:0071350)2.50635991
128regulation of vesicle fusion (GO:0031338)2.49649673
129positive regulation of mRNA catabolic process (GO:0061014)2.49632290
130detection of light stimulus (GO:0009583)2.49571473
131regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.49477408
132antigen processing and presentation of endogenous antigen (GO:0019883)2.49017493
133regulation of synaptic transmission, glutamatergic (GO:0051966)2.48358631
134membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.47756039
135positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.47680788
136mast cell activation involved in immune response (GO:0002279)2.47178980
137mast cell degranulation (GO:0043303)2.47178980
138neurotransmitter transport (GO:0006836)2.47079593
139positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.47000583
140regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.47000583
141positive regulation of developmental pigmentation (GO:0048087)2.46946606
142positive regulation of synapse maturation (GO:0090129)2.46011702
143mitotic sister chromatid cohesion (GO:0007064)2.45543674
144inositol phosphate dephosphorylation (GO:0046855)2.45180765
145phosphorylated carbohydrate dephosphorylation (GO:0046838)2.45180765
146positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.44499875
147seminiferous tubule development (GO:0072520)2.44214685
148phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.44190090
149response to interleukin-15 (GO:0070672)2.43034335
150detection of visible light (GO:0009584)2.42997720
151tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.42307356
152RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.42307356
153positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.41843351
154DNA-templated transcription, termination (GO:0006353)2.41741036
155L-fucose catabolic process (GO:0042355)2.37894234
156fucose catabolic process (GO:0019317)2.37894234
157L-fucose metabolic process (GO:0042354)2.37894234
158regulation of granulocyte differentiation (GO:0030852)2.37609338
159regulation of alpha-beta T cell proliferation (GO:0046640)2.36679922
160T cell migration (GO:0072678)2.36565272
161negative regulation of T cell mediated immunity (GO:0002710)2.35631504
162negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.35402669
163negative regulation of translation, ncRNA-mediated (GO:0040033)2.35402669
164regulation of translation, ncRNA-mediated (GO:0045974)2.35402669
165cAMP catabolic process (GO:0006198)2.33979008
166protein complex biogenesis (GO:0070271)2.32138414
167regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.31726310
168cellular response to ethanol (GO:0071361)2.31106152
169positive thymic T cell selection (GO:0045059)2.29639412
170indolalkylamine metabolic process (GO:0006586)2.29233014
171monoamine transport (GO:0015844)2.28621939
172dopamine transport (GO:0015872)2.28142852
173DNA demethylation (GO:0080111)2.25702010
174cyclic nucleotide catabolic process (GO:0009214)2.25064934
175protein localization to Golgi apparatus (GO:0034067)2.24477927
176T cell selection (GO:0045058)2.24451100
177inositol phosphate catabolic process (GO:0071545)2.24307182
178regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.22809091
179regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.22564102
180dentate gyrus development (GO:0021542)2.21208376
181aggressive behavior (GO:0002118)2.20738296
182mitochondrial respiratory chain complex I assembly (GO:0032981)2.20671316
183NADH dehydrogenase complex assembly (GO:0010257)2.20671316
184mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.20671316
185neutrophil mediated immunity (GO:0002446)2.19151787
186nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.18650771
187negative regulation of adaptive immune response (GO:0002820)2.18066492
188RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.17622645
189gamma-aminobutyric acid transport (GO:0015812)2.16830876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.95686748
2EZH2_22144423_ChIP-Seq_EOC_Human3.53080623
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.21290520
4GBX2_23144817_ChIP-Seq_PC3_Human3.15099763
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.97558820
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.87934360
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72566261
8* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.67431616
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65432877
10FUS_26573619_Chip-Seq_HEK293_Human2.59808535
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49718491
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40539924
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.33949363
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.25144275
15TAF15_26573619_Chip-Seq_HEK293_Human2.20632338
16E2F7_22180533_ChIP-Seq_HELA_Human2.19923809
17GATA1_22025678_ChIP-Seq_K562_Human2.18146549
18EWS_26573619_Chip-Seq_HEK293_Human2.17574698
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16195737
20VDR_22108803_ChIP-Seq_LS180_Human2.15677228
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.08460978
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05653273
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04452253
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99395556
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94721125
26AR_21572438_ChIP-Seq_LNCaP_Human1.90275310
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89353565
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79767041
29ZNF274_21170338_ChIP-Seq_K562_Hela1.78972640
30* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.77602463
31REST_21632747_ChIP-Seq_MESCs_Mouse1.74826590
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74656823
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70985715
34RUNX_20019798_ChIP-Seq_JUKART_Human1.70562057
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.68603332
36P300_19829295_ChIP-Seq_ESCs_Human1.68487909
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63484474
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58993258
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58655755
40BCAT_22108803_ChIP-Seq_LS180_Human1.52866316
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50514042
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.50484986
43SMAD4_21799915_ChIP-Seq_A2780_Human1.50420176
44CBP_20019798_ChIP-Seq_JUKART_Human1.48987403
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48987403
46LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47516981
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47127804
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.46798063
49IGF1R_20145208_ChIP-Seq_DFB_Human1.46217208
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43805776
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43805776
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43034906
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.41818229
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.41171722
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39873454
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39819052
57SCL_19346495_ChIP-Seq_HPC-7_Human1.39269039
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37257382
59IRF1_19129219_ChIP-ChIP_H3396_Human1.36916971
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36373234
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.35558359
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35310317
63CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.35225485
64* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34856952
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33707999
66ER_23166858_ChIP-Seq_MCF-7_Human1.33510385
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.33504270
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.32856820
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30627440
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.30478496
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29212268
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27753738
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27544137
74* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26875282
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26685923
76RARB_27405468_Chip-Seq_BRAIN_Mouse1.26402740
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.25277465
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24186980
79* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24094529
80CIITA_25753668_ChIP-Seq_RAJI_Human1.23623440
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23358488
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.23267013
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22969463
84STAT3_23295773_ChIP-Seq_U87_Human1.21718684
85* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20775036
86GATA3_26560356_Chip-Seq_TH2_Human1.20199442
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20144213
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18922602
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17732168
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.17307074
91* TCF4_23295773_ChIP-Seq_U87_Human1.17299524
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.17087066
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16199012
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15492751
95MYB_26560356_Chip-Seq_TH2_Human1.14672513
96TP53_22573176_ChIP-Seq_HFKS_Human1.14329879
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13991495
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13888820
99JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13074447
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12177116
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.11623071
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.10540118
103* RNF2_27304074_Chip-Seq_NSC_Mouse1.10289619
104P300_18555785_Chip-Seq_ESCs_Mouse1.10046067
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09655880
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08411652
107VDR_24787735_ChIP-Seq_THP-1_Human1.07908813
108RUNX2_22187159_ChIP-Seq_PCA_Human1.07380578
109OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07378898
110BP1_19119308_ChIP-ChIP_Hs578T_Human1.07319539
111P53_22387025_ChIP-Seq_ESCs_Mouse1.07219494
112SOX2_19829295_ChIP-Seq_ESCs_Human1.06868942
113NANOG_19829295_ChIP-Seq_ESCs_Human1.06868942
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06729091
115GATA3_27048872_Chip-Seq_THYMUS_Human1.06031882
116FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05733657
117EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05447291
118SOX9_26525672_Chip-Seq_HEART_Mouse1.05236518
119PIAS1_25552417_ChIP-Seq_VCAP_Human1.05170241
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04214406
121TCF4_22108803_ChIP-Seq_LS180_Human1.03569393
122TAL1_26923725_Chip-Seq_HPCs_Mouse1.01899091
123TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01578850
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.01288282
125AR_25329375_ChIP-Seq_VCAP_Human1.00516587
126* CMYC_18555785_Chip-Seq_ESCs_Mouse1.00341895
127VDR_23849224_ChIP-Seq_CD4+_Human0.99428912
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99082400
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98775081
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97891503
131PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97650255
132EZH2_27304074_Chip-Seq_ESCs_Mouse0.97506977
133STAT3_18555785_Chip-Seq_ESCs_Mouse0.97442032
134DROSHA_22980978_ChIP-Seq_HELA_Human0.97215517
135ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96462065
136YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96307954
137SMRT_27268052_Chip-Seq_Bcells_Human0.96098621
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96085215
139TP53_16413492_ChIP-PET_HCT116_Human0.95935865
140PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95906057
141BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95480407
142SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95324827
143NMYC_18555785_Chip-Seq_ESCs_Mouse0.95009722
144PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94902092
145SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94420811
146KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.94402982

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog4.52585754
2MP0006072_abnormal_retinal_apoptosis4.39264495
3MP0006292_abnormal_olfactory_placode3.36278193
4MP0005253_abnormal_eye_physiology3.09536730
5MP0003880_abnormal_central_pattern2.70267885
6MP0003787_abnormal_imprinting2.67849092
7MP0005423_abnormal_somatic_nervous2.65408340
8MP0001984_abnormal_olfaction2.64662978
9MP0002638_abnormal_pupillary_reflex2.62092341
10MP0001188_hyperpigmentation2.61117096
11MP0004859_abnormal_synaptic_plasticity2.48336645
12MP0001835_abnormal_antigen_presentation2.42756523
13MP0001486_abnormal_startle_reflex2.37332838
14MP0004270_analgesia2.35986602
15MP0005646_abnormal_pituitary_gland2.34371076
16MP0003635_abnormal_synaptic_transmissio2.31666294
17MP0009046_muscle_twitch2.17667235
18MP0003011_delayed_dark_adaptation2.02971482
19MP0003195_calcinosis2.01113579
20MP0001502_abnormal_circadian_rhythm1.95494662
21MP0009745_abnormal_behavioral_response1.91672628
22MP0003724_increased_susceptibility_to1.91376648
23MP0002272_abnormal_nervous_system1.84890951
24MP0002009_preneoplasia1.84317973
25MP0008995_early_reproductive_senescence1.83217016
26MP0005195_abnormal_posterior_eye1.81856021
27MP0002734_abnormal_mechanical_nocicepti1.80853131
28MP0001800_abnormal_humoral_immune1.79841269
29MP0002064_seizures1.79746034
30MP0002572_abnormal_emotion/affect_behav1.77806103
31MP0002063_abnormal_learning/memory/cond1.71373307
32MP0008877_abnormal_DNA_methylation1.68916023
33MP0004147_increased_porphyrin_level1.68828573
34MP0002067_abnormal_sensory_capabilities1.66980082
35MP0001986_abnormal_taste_sensitivity1.64996356
36MP0002229_neurodegeneration1.64044945
37MP0003890_abnormal_embryonic-extraembry1.63753013
38MP0002090_abnormal_vision1.58766315
39MP0004142_abnormal_muscle_tone1.55887774
40MP0003646_muscle_fatigue1.53222298
41MP0005075_abnormal_melanosome_morpholog1.48992226
42MP0003763_abnormal_thymus_physiology1.48222244
43MP0003121_genomic_imprinting1.48133378
44MP0002396_abnormal_hematopoietic_system1.46990163
45MP0002837_dystrophic_cardiac_calcinosis1.45665499
46MP0001501_abnormal_sleep_pattern1.43463398
47MP0010094_abnormal_chromosome_stability1.42539652
48MP0005391_vision/eye_phenotype1.42116787
49MP0002882_abnormal_neuron_morphology1.39392656
50MP0008569_lethality_at_weaning1.39284754
51MP0008007_abnormal_cellular_replicative1.38869555
52MP0000631_abnormal_neuroendocrine_gland1.35928435
53MP0001529_abnormal_vocalization1.35780124
54MP0002723_abnormal_immune_serum1.35747846
55MP0002752_abnormal_somatic_nervous1.35396455
56MP0000778_abnormal_nervous_system1.35126140
57MP0003183_abnormal_peptide_metabolism1.34728376
58MP0005394_taste/olfaction_phenotype1.34711416
59MP0005499_abnormal_olfactory_system1.34711416
60MP0002876_abnormal_thyroid_physiology1.34090612
61MP0005397_hematopoietic_system_phenotyp1.32425216
62MP0001545_abnormal_hematopoietic_system1.32425216
63MP0004924_abnormal_behavior1.30351497
64MP0005386_behavior/neurological_phenoty1.30351497
65MP0001790_abnormal_immune_system1.28449720
66MP0005387_immune_system_phenotype1.28449720
67MP0005000_abnormal_immune_tolerance1.28203156
68MP0002184_abnormal_innervation1.27908583
69MP0002420_abnormal_adaptive_immunity1.27374565
70MP0006276_abnormal_autonomic_nervous1.25147866
71MP0002822_catalepsy1.23788139
72MP0001819_abnormal_immune_cell1.23441727
73MP0008058_abnormal_DNA_repair1.23282839
74MP0000566_synostosis1.22442604
75MP0003111_abnormal_nucleus_morphology1.21628649
76MP0002452_abnormal_antigen_presenting1.21477554
77MP0002557_abnormal_social/conspecific_i1.18600537
78MP0009278_abnormal_bone_marrow1.17104522
79MP0002653_abnormal_ependyma_morphology1.15214596
80MP0002736_abnormal_nociception_after1.13120620
81MP0006035_abnormal_mitochondrial_morpho1.12751186
82MP0003045_fibrosis1.12572146
83MP0000955_abnormal_spinal_cord1.09965703
84MP0008872_abnormal_physiological_respon1.09424103
85MP0001440_abnormal_grooming_behavior1.08669991
86MP0005645_abnormal_hypothalamus_physiol1.08553725
87MP0002928_abnormal_bile_duct1.08226718
88MP0002398_abnormal_bone_marrow1.08122628
89MP0010386_abnormal_urinary_bladder1.07740178
90MP0000372_irregular_coat_pigmentation1.07599474
91MP0009785_altered_susceptibility_to1.07404595
92MP0002277_abnormal_respiratory_mucosa1.06085776
93MP0008789_abnormal_olfactory_epithelium1.05491463
94MP0002132_abnormal_respiratory_system1.04415560
95MP0000716_abnormal_immune_system1.03558314
96MP0005379_endocrine/exocrine_gland_phen1.02031800
97MP0005025_abnormal_response_to1.01660854
98MP0004215_abnormal_myocardial_fiber1.01645576
99MP0002152_abnormal_brain_morphology1.01259119
100MP0001968_abnormal_touch/_nociception1.00217543
101MP0001485_abnormal_pinna_reflex0.97869585
102MP0009697_abnormal_copulation0.97126766
103MP0002419_abnormal_innate_immunity0.95932298
104MP0001324_abnormal_eye_pigmentation0.95240658
105MP0000689_abnormal_spleen_morphology0.94992930
106MP0005535_abnormal_body_temperature0.94005453
107MP0004043_abnormal_pH_regulation0.93350541
108MP0001963_abnormal_hearing_physiology0.89596971
109MP0002102_abnormal_ear_morphology0.88468301
110MP0008057_abnormal_DNA_replication0.88080729
111MP0004484_altered_response_of0.87192772
112MP0005174_abnormal_tail_pigmentation0.86728373
113MP0000685_abnormal_immune_system0.85997045
114MP0002148_abnormal_hypersensitivity_rea0.84947473
115MP0002066_abnormal_motor_capabilities/c0.84910837
116MP0005671_abnormal_response_to0.84801858
117MP0008775_abnormal_heart_ventricle0.84571847
118MP0006036_abnormal_mitochondrial_physio0.84458732
119MP0002405_respiratory_system_inflammati0.84148345
120MP0005409_darkened_coat_color0.84084488
121MP0003866_abnormal_defecation0.84025249
122MP0001764_abnormal_homeostasis0.83179214
123MP0004084_abnormal_cardiac_muscle0.83008550
124MP0005220_abnormal_exocrine_pancreas0.82576309
125MP0002166_altered_tumor_susceptibility0.81685606
126MP0003137_abnormal_impulse_conducting0.81612097
127MP0002095_abnormal_skin_pigmentation0.81400717
128MP0002909_abnormal_adrenal_gland0.81195185
129MP0001286_abnormal_eye_development0.80642872
130MP0002138_abnormal_hepatobiliary_system0.79604460
131MP0001970_abnormal_pain_threshold0.79068963
132MP0008961_abnormal_basal_metabolism0.78899643
133MP0004130_abnormal_muscle_cell0.78414265
134MP0000703_abnormal_thymus_morphology0.77794208
135MP0003698_abnormal_male_reproductive0.75968946
136MP0003950_abnormal_plasma_membrane0.75301380
137MP0002722_abnormal_immune_system0.75013268
138MP0001873_stomach_inflammation0.74185955
139MP0004885_abnormal_endolymph0.73489166
140MP0002735_abnormal_chemical_nociception0.73297589
141MP0004742_abnormal_vestibular_system0.71672537
142MP0003861_abnormal_nervous_system0.71156588
143MP0004811_abnormal_neuron_physiology0.70536769
144MP0002733_abnormal_thermal_nociception0.70205068
145MP0001346_abnormal_lacrimal_gland0.69371560
146MP0000569_abnormal_digit_pigmentation0.68961124
147MP0002210_abnormal_sex_determination0.67544839
148MP0001929_abnormal_gametogenesis0.67236863
149MP0002163_abnormal_gland_morphology0.66014146
150MP0003077_abnormal_cell_cycle0.65252086
151MP0004145_abnormal_muscle_electrophysio0.64962546
152MP0003693_abnormal_embryo_hatching0.64906086
153MP0001661_extended_life_span0.63918513
154MP0001905_abnormal_dopamine_level0.63583222

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.28288739
2Central scotoma (HP:0000603)5.22010774
3Abnormal rod and cone electroretinograms (HP:0008323)4.38903414
4Severe visual impairment (HP:0001141)4.25107505
5Dyschromatopsia (HP:0007641)4.17706440
6Panhypogammaglobulinemia (HP:0003139)4.13943071
7Abnormality of macular pigmentation (HP:0008002)4.01500073
8Bony spicule pigmentary retinopathy (HP:0007737)3.96737239
9Scotoma (HP:0000575)3.82598205
10Pendular nystagmus (HP:0012043)3.55450616
11Decreased central vision (HP:0007663)3.45641263
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.45160061
13Epileptic encephalopathy (HP:0200134)3.42610823
14Excessive salivation (HP:0003781)3.33059902
15Drooling (HP:0002307)3.33059902
16Pancreatic fibrosis (HP:0100732)3.14013551
17Absent/shortened dynein arms (HP:0200106)3.12652547
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.12652547
19Abnormality of midbrain morphology (HP:0002418)3.08707982
20Molar tooth sign on MRI (HP:0002419)3.08707982
21Attenuation of retinal blood vessels (HP:0007843)3.02650184
22Focal motor seizures (HP:0011153)3.02444634
23True hermaphroditism (HP:0010459)2.98747330
24Hyperventilation (HP:0002883)2.97744269
25Abnormal delayed hypersensitivity skin test (HP:0002963)2.96756496
26Volvulus (HP:0002580)2.94790547
27Abnormality of B cell number (HP:0010975)2.94031705
28T lymphocytopenia (HP:0005403)2.90998732
29Febrile seizures (HP:0002373)2.89671384
30Abnormality of T cell number (HP:0011839)2.89162605
31Stomach cancer (HP:0012126)2.82539215
32Mutism (HP:0002300)2.82092672
33Esotropia (HP:0000565)2.71672685
34Abnormality of the renal cortex (HP:0011035)2.71444978
35Abnormality of the renal medulla (HP:0100957)2.71132730
36Pancreatic cysts (HP:0001737)2.70390749
37B lymphocytopenia (HP:0010976)2.69849474
38Chronic hepatic failure (HP:0100626)2.59132026
39Abnormal respiratory motile cilium morphology (HP:0005938)2.57070461
40Abnormal respiratory epithelium morphology (HP:0012253)2.57070461
41Abnormal ciliary motility (HP:0012262)2.56742387
42Vitreoretinal degeneration (HP:0000655)2.56302466
43Hypoproteinemia (HP:0003075)2.53025894
44Stomatitis (HP:0010280)2.52090211
45Recurrent fungal infections (HP:0002841)2.49596540
46Impaired smooth pursuit (HP:0007772)2.48828266
47Chronic otitis media (HP:0000389)2.47528288
48Protruding tongue (HP:0010808)2.46165164
49Gaze-evoked nystagmus (HP:0000640)2.41958832
50Renal cortical cysts (HP:0000803)2.40238504
51Optic nerve coloboma (HP:0000588)2.39719106
52Bifid tongue (HP:0010297)2.38424353
53Elevated erythrocyte sedimentation rate (HP:0003565)2.36361551
54Progressive cerebellar ataxia (HP:0002073)2.36287609
55Myositis (HP:0100614)2.34200005
56Agammaglobulinemia (HP:0004432)2.32134358
57Tubulointerstitial nephritis (HP:0001970)2.31398555
58Chronic sinusitis (HP:0011109)2.28650629
59Abnormality of ocular smooth pursuit (HP:0000617)2.25526411
60Eosinophilia (HP:0001880)2.25398900
61Birth length less than 3rd percentile (HP:0003561)2.24465689
62Gait imbalance (HP:0002141)2.23339745
63Abnormality of eosinophils (HP:0001879)2.23335609
64Combined immunodeficiency (HP:0005387)2.22599595
65Upper motor neuron abnormality (HP:0002127)2.22333642
66Keratoconus (HP:0000563)2.21614849
67Increased corneal curvature (HP:0100692)2.21614849
68Encephalitis (HP:0002383)2.20954287
69Abnormality of T cells (HP:0002843)2.19868718
70Retinitis pigmentosa (HP:0000510)2.19477737
71CNS hypomyelination (HP:0003429)2.18493199
72Photophobia (HP:0000613)2.17030805
73Aplasia/Hypoplasia of the fovea (HP:0008060)2.15968668
74Hypoplasia of the fovea (HP:0007750)2.15968668
75Chorioretinal atrophy (HP:0000533)2.15611808
76Neoplasm of the tracheobronchial system (HP:0100552)2.15557849
77Genetic anticipation (HP:0003743)2.14647551
78Abnormal respiratory motile cilium physiology (HP:0012261)2.13831623
79Absent speech (HP:0001344)2.13381691
80Recurrent cutaneous fungal infections (HP:0011370)2.12954439
81Chronic mucocutaneous candidiasis (HP:0002728)2.12954439
82Split foot (HP:0001839)2.12123806
83Atonic seizures (HP:0010819)2.12011303
84Abnormality of salivation (HP:0100755)2.09516585
85Medial flaring of the eyebrow (HP:0010747)2.09397605
86Congenital primary aphakia (HP:0007707)2.09049657
87Median cleft lip (HP:0000161)2.08461805
88Type II diabetes mellitus (HP:0005978)2.07325449
89Oligodactyly (hands) (HP:0001180)2.07316283
90Truncal ataxia (HP:0002078)2.07111456
91Abnormality of the fovea (HP:0000493)2.06949931
92Leukocytosis (HP:0001974)2.06770548
93Granulocytopenia (HP:0001913)2.04724140
94Cystic liver disease (HP:0006706)2.04346743
95Postural tremor (HP:0002174)2.03737174
96Nephrogenic diabetes insipidus (HP:0009806)2.03159916
97Retrobulbar optic neuritis (HP:0100654)2.02294210
98Optic neuritis (HP:0100653)2.02294210
99Hypoplasia of the thymus (HP:0000778)1.99581770
100Papilledema (HP:0001085)1.98258202
1013-Methylglutaconic aciduria (HP:0003535)1.98071618
102Broad-based gait (HP:0002136)1.97169918
103Recurrent bronchitis (HP:0002837)1.96946010
104Meningitis (HP:0001287)1.95859165
105Alveolar cell carcinoma (HP:0006519)1.95529259
106Septo-optic dysplasia (HP:0100842)1.94839273
107Dysmetria (HP:0001310)1.92921936
108Congenital hepatic fibrosis (HP:0002612)1.91765899
109Hypothermia (HP:0002045)1.91558529
110Abnormal drinking behavior (HP:0030082)1.90637791
111Polydipsia (HP:0001959)1.90637791
112Abolished electroretinogram (ERG) (HP:0000550)1.90020916
113Hypochromic microcytic anemia (HP:0004840)1.89648296
114Pigmentary retinal degeneration (HP:0001146)1.89221571
115Absence seizures (HP:0002121)1.88847658
116Scanning speech (HP:0002168)1.88420369
117Visual hallucinations (HP:0002367)1.86871482
118Thyroiditis (HP:0100646)1.83779577
119Abnormality of the columella (HP:0009929)1.83275920
120Type I transferrin isoform profile (HP:0003642)1.82624237
121Constricted visual fields (HP:0001133)1.81855424
122Widely spaced teeth (HP:0000687)1.81740721
123Choroideremia (HP:0001139)1.81521219
124Recurrent bacterial skin infections (HP:0005406)1.80988801
125Chorioretinal coloboma (HP:0000567)1.80955868
126Abnormality of the fingertips (HP:0001211)1.79514325
127Preaxial hand polydactyly (HP:0001177)1.77509777
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.76247003
129Recurrent viral infections (HP:0004429)1.75541426
130Thyroid-stimulating hormone excess (HP:0002925)1.75051180
131Dyskinesia (HP:0100660)1.74821313
132Mitochondrial inheritance (HP:0001427)1.74015597
133Severe combined immunodeficiency (HP:0004430)1.73983124
134Amyotrophic lateral sclerosis (HP:0007354)1.73862259
135Supernumerary spleens (HP:0009799)1.73230475
136Abnormality of the labia minora (HP:0012880)1.73122931
137Optic nerve hypoplasia (HP:0000609)1.72334728
138Neoplasm of the oral cavity (HP:0100649)1.71872732
139Hepatocellular necrosis (HP:0001404)1.71697705
140Type II lissencephaly (HP:0007260)1.71492341
141Congenital sensorineural hearing impairment (HP:0008527)1.71073278
142Genital tract atresia (HP:0001827)1.70694005
143Anencephaly (HP:0002323)1.69182155
144Highly arched eyebrow (HP:0002553)1.67861390
145Progressive inability to walk (HP:0002505)1.67841364
146Hemiparesis (HP:0001269)1.66353937
147Focal seizures (HP:0007359)1.66062303
148Postaxial foot polydactyly (HP:0001830)1.64349591
149Bile duct proliferation (HP:0001408)1.64329664
150Abnormal biliary tract physiology (HP:0012439)1.64329664
151Medulloblastoma (HP:0002885)1.63185159
152Poor coordination (HP:0002370)1.63019777
153Nephronophthisis (HP:0000090)1.62555615
154Dialeptic seizures (HP:0011146)1.62367740
155Acute lymphatic leukemia (HP:0006721)1.60480603
156Absent septum pellucidum (HP:0001331)1.60290427
157Narrow forehead (HP:0000341)1.59289076
158Macular degeneration (HP:0000608)1.58042393
159Dysdiadochokinesis (HP:0002075)1.57654417
160IgG deficiency (HP:0004315)1.56175329
161Abnormality of the septum pellucidum (HP:0007375)1.55818419
162Flat capital femoral epiphysis (HP:0003370)1.53505012
163Small hand (HP:0200055)1.53419025
164Truncal obesity (HP:0001956)1.53024810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.48583798
2TNIK3.87688679
3SIK23.12025360
4TAOK32.87811272
5NTRK32.71180750
6BRD42.47743602
7MUSK2.38473808
8SRPK12.37319919
9MKNK22.31206629
10INSRR2.18811421
11TEC2.18705748
12MAP4K22.12186326
13EPHA41.96699422
14CCNB11.95572496
15CASK1.93943588
16MAP4K11.92199857
17DYRK1A1.88388382
18CDK121.83376752
19MAPK131.82183983
20EPHA31.75849889
21KIT1.70265288
22GRK11.63254794
23SIK31.59250339
24RIPK41.57503669
25MAP3K41.54664663
26CDC71.54483896
27NUAK11.54165930
28IRAK21.53647364
29NEK61.53238171
30MAP2K71.52802009
31ITK1.51434465
32SYK1.50136461
33NLK1.46292193
34NME11.45333822
35MARK11.45306633
36TNK21.40894364
37PIK3CG1.35659533
38SGK21.35183453
39OBSCN1.33891605
40BTK1.33041363
41ERBB31.33024385
42TXK1.32311378
43ACVR1B1.31782295
44MKNK11.26946924
45FLT31.21957787
46CDK31.20642972
47MAP3K131.19266197
48ADRBK21.18903081
49PNCK1.18864439
50DYRK31.18735676
51SGK2231.18692579
52SGK4941.18692579
53NTRK21.16790129
54CSF1R1.15096909
55WNK31.14306187
56CAMKK21.12201567
57CDK81.11122866
58IKBKE1.09062407
59PRKD31.06480512
60HIPK21.05660079
61LYN1.02510232
62FGFR21.01456267
63OXSR11.01235027
64PRKAA21.00798193
65MARK30.96900373
66PAK30.93926113
67BLK0.91901773
68LCK0.91502667
69IRAK10.91013290
70MAPK150.90363584
71PTK2B0.88816516
72PHKG20.88319018
73PHKG10.88319018
74VRK10.87500202
75MAP3K70.87418999
76RPS6KB10.87381751
77STK160.87117522
78EIF2AK20.87000174
79PRKCQ0.83580872
80TYK20.83360444
81AKT30.82641841
82CHEK20.80380667
83TLK10.79750873
84ATR0.79684639
85STK110.79182142
86CDK90.78629914
87SGK10.78547252
88PRKCE0.78523495
89JAK30.77883678
90RPS6KA50.77536594
91PRKCG0.76570592
92IKBKB0.76090677
93BMPR20.75461447
94MARK20.74021523
95SIK10.73605396
96DAPK20.73415713
97YES10.72629297
98HCK0.72554173
99GRK60.72011117
100JAK10.71291271
101MAP3K90.70969992
102GRK70.70034050
103MAP2K60.69589168
104ZAK0.67742217
105PRKD20.66802302
106SGK30.66555358
107MAPK100.66269446
108IRAK40.65328048
109BCR0.65268535
110CDK10.65228746
111PINK10.64855828
112ADRBK10.63531916
113TRPM70.63114956
114ATM0.63064596
115FGFR30.62820263
116PKN10.62227665
117MAPK120.61746804
118RPS6KA30.59971202
119ZAP700.59554836
120UHMK10.59245408
121CAMK1G0.58948507
122CDK50.57207943
123GSK3B0.56775374
124PRKAA10.56129399
125PRKCB0.55367573
126CSNK1A1L0.55356071
127TRIM280.55177617
128DYRK20.54486628
129PRKG10.53973217
130BMPR1B0.53913814
131MAPK70.53352675
132CAMKK10.52606093
133CDK20.51920294
134PLK30.51781182
135PLK10.50727494
136PRKDC0.50453169
137JAK20.50412982
138BRAF0.50151295
139WNK10.48311475
140BUB10.47796694
141CSK0.46428751
142MAPK140.46263031
143TBK10.46085581
144AURKB0.45902359
145PRKACA0.45794640
146DYRK1B0.44680399
147EIF2AK10.44376602
148FES0.43876773
149PRKCH0.43753843
150CAMK2A0.43499341
151MAPK80.43248543
152PAK60.42691499
153PLK20.42620348
154CDC42BPA0.42341105
155CAMK10.42263002
156MAP2K40.42070943
157CHEK10.41718430
158FGR0.40539626
159CDK190.38942590
160TGFBR10.38757319

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.28071933
2Nicotine addiction_Homo sapiens_hsa050334.14424634
3GABAergic synapse_Homo sapiens_hsa047272.95286118
4RNA polymerase_Homo sapiens_hsa030202.82870724
5Morphine addiction_Homo sapiens_hsa050322.68079638
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54898739
7Graft-versus-host disease_Homo sapiens_hsa053322.41930848
8Circadian entrainment_Homo sapiens_hsa047132.23757967
9Glutamatergic synapse_Homo sapiens_hsa047242.21089187
10Spliceosome_Homo sapiens_hsa030402.02993829
11Circadian rhythm_Homo sapiens_hsa047102.02863287
12Olfactory transduction_Homo sapiens_hsa047402.00991716
13Linoleic acid metabolism_Homo sapiens_hsa005911.81984617
14RNA degradation_Homo sapiens_hsa030181.79635613
15Synaptic vesicle cycle_Homo sapiens_hsa047211.79285868
16Fanconi anemia pathway_Homo sapiens_hsa034601.77803662
17Non-homologous end-joining_Homo sapiens_hsa034501.71829373
18Taste transduction_Homo sapiens_hsa047421.71725478
19Insulin secretion_Homo sapiens_hsa049111.69633276
20Alcoholism_Homo sapiens_hsa050341.63798606
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59310888
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57967494
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54638864
24Long-term potentiation_Homo sapiens_hsa047201.53402672
25mRNA surveillance pathway_Homo sapiens_hsa030151.52556650
26Homologous recombination_Homo sapiens_hsa034401.49864167
27Serotonergic synapse_Homo sapiens_hsa047261.49545258
28Amphetamine addiction_Homo sapiens_hsa050311.48769777
29Dopaminergic synapse_Homo sapiens_hsa047281.48574967
30Systemic lupus erythematosus_Homo sapiens_hsa053221.46825070
31Oxidative phosphorylation_Homo sapiens_hsa001901.45615136
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42165923
33Basal transcription factors_Homo sapiens_hsa030221.40476832
34Ether lipid metabolism_Homo sapiens_hsa005651.40078407
35Nitrogen metabolism_Homo sapiens_hsa009101.37496974
36Staphylococcus aureus infection_Homo sapiens_hsa051501.33026518
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32742366
38Renin secretion_Homo sapiens_hsa049241.28690366
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26264094
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23731595
41Leishmaniasis_Homo sapiens_hsa051401.23664051
42Cholinergic synapse_Homo sapiens_hsa047251.23208318
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22892787
44Primary immunodeficiency_Homo sapiens_hsa053401.22815757
45Parkinsons disease_Homo sapiens_hsa050121.22538542
46DNA replication_Homo sapiens_hsa030301.22107794
47Salivary secretion_Homo sapiens_hsa049701.21780995
48Antigen processing and presentation_Homo sapiens_hsa046121.20986742
49Hematopoietic cell lineage_Homo sapiens_hsa046401.19113701
50Purine metabolism_Homo sapiens_hsa002301.18529564
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17527731
52Mismatch repair_Homo sapiens_hsa034301.17248763
53Oocyte meiosis_Homo sapiens_hsa041141.14667629
54Butanoate metabolism_Homo sapiens_hsa006501.12565702
55Cell cycle_Homo sapiens_hsa041101.08236323
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07770225
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05256820
58Rheumatoid arthritis_Homo sapiens_hsa053231.04235572
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03604683
60Calcium signaling pathway_Homo sapiens_hsa040201.03588055
61Folate biosynthesis_Homo sapiens_hsa007901.01731697
62Type I diabetes mellitus_Homo sapiens_hsa049401.01282351
63Cardiac muscle contraction_Homo sapiens_hsa042601.00715565
64Long-term depression_Homo sapiens_hsa047300.99557705
65Oxytocin signaling pathway_Homo sapiens_hsa049210.98298399
66Allograft rejection_Homo sapiens_hsa053300.97534031
67Protein export_Homo sapiens_hsa030600.95290955
68Collecting duct acid secretion_Homo sapiens_hsa049660.94856520
69Cocaine addiction_Homo sapiens_hsa050300.94778219
70Pyrimidine metabolism_Homo sapiens_hsa002400.94088202
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.93735717
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93530191
73T cell receptor signaling pathway_Homo sapiens_hsa046600.93008986
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87545522
75cAMP signaling pathway_Homo sapiens_hsa040240.85863243
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85285931
77Arachidonic acid metabolism_Homo sapiens_hsa005900.81748679
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81286387
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.80749132
80Platelet activation_Homo sapiens_hsa046110.78511137
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77476402
82Measles_Homo sapiens_hsa051620.77023073
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76617092
84Propanoate metabolism_Homo sapiens_hsa006400.74154778
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72944614
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72808111
87Alzheimers disease_Homo sapiens_hsa050100.72785234
88Peroxisome_Homo sapiens_hsa041460.72753705
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72103072
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71439662
91Gastric acid secretion_Homo sapiens_hsa049710.70891789
92Caffeine metabolism_Homo sapiens_hsa002320.69039997
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67835456
94Osteoclast differentiation_Homo sapiens_hsa043800.67792313
95RNA transport_Homo sapiens_hsa030130.66956360
96Tuberculosis_Homo sapiens_hsa051520.65118087
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64781491
98B cell receptor signaling pathway_Homo sapiens_hsa046620.64320336
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63898214
100Huntingtons disease_Homo sapiens_hsa050160.63853417
101Herpes simplex infection_Homo sapiens_hsa051680.63329684
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62390493
103Base excision repair_Homo sapiens_hsa034100.62098297
104Autoimmune thyroid disease_Homo sapiens_hsa053200.60774511
105Regulation of autophagy_Homo sapiens_hsa041400.60759044
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60721478
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60533446
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59084922
109Tryptophan metabolism_Homo sapiens_hsa003800.57373875
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56203032
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56067501
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.55306337
113Nucleotide excision repair_Homo sapiens_hsa034200.54169174
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53705302
115Fructose and mannose metabolism_Homo sapiens_hsa000510.53518105
116Selenocompound metabolism_Homo sapiens_hsa004500.52976900
117Type II diabetes mellitus_Homo sapiens_hsa049300.52883048
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52612951
119Ovarian steroidogenesis_Homo sapiens_hsa049130.51859432
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50677812
121Viral myocarditis_Homo sapiens_hsa054160.49371866
122Chemical carcinogenesis_Homo sapiens_hsa052040.47977853
123Fatty acid biosynthesis_Homo sapiens_hsa000610.44414847
124Inositol phosphate metabolism_Homo sapiens_hsa005620.43533805
125Choline metabolism in cancer_Homo sapiens_hsa052310.42915195
126MAPK signaling pathway_Homo sapiens_hsa040100.41486930
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.40831991
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39523327
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38316627
130Lysine degradation_Homo sapiens_hsa003100.38301532
131Pancreatic secretion_Homo sapiens_hsa049720.37170414
132Glucagon signaling pathway_Homo sapiens_hsa049220.36229323
133GnRH signaling pathway_Homo sapiens_hsa049120.34837629
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.34648549
135Gap junction_Homo sapiens_hsa045400.34071866
136Axon guidance_Homo sapiens_hsa043600.33561073
137Sphingolipid metabolism_Homo sapiens_hsa006000.32935910
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30866377
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.30170593
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27517183
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27486936
142Dorso-ventral axis formation_Homo sapiens_hsa043200.27407036
143Asthma_Homo sapiens_hsa053100.26716204
144N-Glycan biosynthesis_Homo sapiens_hsa005100.26092863
145ABC transporters_Homo sapiens_hsa020100.25213274

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