RNPEPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)6.70157238
2lens fiber cell development (GO:0070307)6.28986603
3positive regulation of isotype switching (GO:0045830)5.73703287
4activated T cell proliferation (GO:0050798)5.70336802
5negative regulation of cell killing (GO:0031342)4.91604249
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.91604249
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.90767341
8positive regulation of DNA recombination (GO:0045911)4.83348659
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.82210713
10L-phenylalanine catabolic process (GO:0006559)4.82210713
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.65764069
12L-phenylalanine metabolic process (GO:0006558)4.65764069
13positive regulation of gamma-delta T cell activation (GO:0046645)4.58439026
14positive regulation of B cell mediated immunity (GO:0002714)4.13855156
15positive regulation of immunoglobulin mediated immune response (GO:0002891)4.13855156
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.11703593
17regulation of B cell receptor signaling pathway (GO:0050855)4.10228044
18regulation of NFAT protein import into nucleus (GO:0051532)4.07320659
19macrophage activation involved in immune response (GO:0002281)3.99275811
20aromatic amino acid family catabolic process (GO:0009074)3.95413506
21response to laminar fluid shear stress (GO:0034616)3.92307275
22toxin transport (GO:1901998)3.90423223
23regulation of isotype switching (GO:0045191)3.88436261
24regulation of cholesterol esterification (GO:0010872)3.82714334
25detection of bacterium (GO:0016045)3.80562196
26lymphocyte migration (GO:0072676)3.80021030
27alpha-linolenic acid metabolic process (GO:0036109)3.79437273
28detection of other organism (GO:0098543)3.77586284
29interferon-gamma production (GO:0032609)3.73578486
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.73100188
31positive regulation of immunoglobulin production (GO:0002639)3.69364161
32positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.65326224
33leukocyte aggregation (GO:0070486)3.65174557
34histamine transport (GO:0051608)3.63868376
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.60800756
36positive regulation by organism of defense response of other organism involved in symbiotic interact3.60800756
37modulation by symbiont of host immune response (GO:0052553)3.60800756
38positive regulation by symbiont of host defense response (GO:0052509)3.60800756
39modulation by symbiont of host defense response (GO:0052031)3.60800756
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.60800756
41sulfur amino acid catabolic process (GO:0000098)3.58350235
42pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.54896882
43UMP metabolic process (GO:0046049)3.54896882
44pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.54896882
45UMP biosynthetic process (GO:0006222)3.54896882
46neutrophil activation involved in immune response (GO:0002283)3.53265666
47regulation of triglyceride catabolic process (GO:0010896)3.52636403
48negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.52631095
49valine metabolic process (GO:0006573)3.51303523
50homocysteine metabolic process (GO:0050667)3.50150780
51cysteine metabolic process (GO:0006534)3.48880362
52peptidyl-glutamic acid carboxylation (GO:0017187)3.48062479
53protein carboxylation (GO:0018214)3.48062479
54negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.47388531
55glyoxylate metabolic process (GO:0046487)3.45553551
56regulation of gamma-delta T cell activation (GO:0046643)3.43919844
57phospholipid efflux (GO:0033700)3.43250845
58kynurenine metabolic process (GO:0070189)3.41567893
59lysine metabolic process (GO:0006553)3.39916910
60lysine catabolic process (GO:0006554)3.39916910
61negative regulation of erythrocyte differentiation (GO:0045647)3.39912836
62immunoglobulin mediated immune response (GO:0016064)3.36228622
63negative regulation of T-helper cell differentiation (GO:0045623)3.32892102
64negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.32892102
65positive regulation of Cdc42 GTPase activity (GO:0043089)3.32878161
66fatty acid beta-oxidation (GO:0006635)3.31545860
67tryptophan catabolic process (GO:0006569)3.30996721
68indole-containing compound catabolic process (GO:0042436)3.30996721
69indolalkylamine catabolic process (GO:0046218)3.30996721
70plasma lipoprotein particle clearance (GO:0034381)3.29608670
71regulation of necroptotic process (GO:0060544)3.29175998
72myeloid cell activation involved in immune response (GO:0002275)3.28732811
73regulation of gamma-delta T cell differentiation (GO:0045586)3.27228660
74regulation of cholesterol homeostasis (GO:2000188)3.26818288
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26167482
76cellular response to exogenous dsRNA (GO:0071360)3.23296674
77response to peptidoglycan (GO:0032494)3.22538943
78short-chain fatty acid metabolic process (GO:0046459)3.19793650
79cell-cell junction maintenance (GO:0045217)3.19739059
80high-density lipoprotein particle remodeling (GO:0034375)3.15449222
81amyloid precursor protein catabolic process (GO:0042987)3.15349621
82negative regulation of cholesterol transport (GO:0032375)3.15027367
83negative regulation of sterol transport (GO:0032372)3.15027367
84complement activation, alternative pathway (GO:0006957)3.14963007
85fatty acid catabolic process (GO:0009062)3.10126824
86growth hormone receptor signaling pathway (GO:0060396)3.09033333
87amino-acid betaine metabolic process (GO:0006577)3.09031618
88fatty acid oxidation (GO:0019395)3.07790711
89intestinal cholesterol absorption (GO:0030299)3.06954563
90regulation of immunoglobulin mediated immune response (GO:0002889)3.06758916
91low-density lipoprotein particle remodeling (GO:0034374)3.06491599
92tryptophan metabolic process (GO:0006568)3.06254529
93regulation of B cell mediated immunity (GO:0002712)3.06088645
94negative regulation of necroptotic process (GO:0060546)3.04185032
95detection of external biotic stimulus (GO:0098581)3.04053918
96lipid oxidation (GO:0034440)3.03662801
97bile acid biosynthetic process (GO:0006699)3.01707078
98creatine metabolic process (GO:0006600)3.00127667
99regulation of T cell tolerance induction (GO:0002664)2.98823762
100cellular response to fluid shear stress (GO:0071498)2.97663963
101leukocyte degranulation (GO:0043299)2.95272304
102antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.94620578
103antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94620578
104mast cell activation involved in immune response (GO:0002279)2.94459575
105mast cell degranulation (GO:0043303)2.94459575
106protein-lipid complex remodeling (GO:0034368)2.94442820
107macromolecular complex remodeling (GO:0034367)2.94442820
108plasma lipoprotein particle remodeling (GO:0034369)2.94442820
109regulation of cholesterol metabolic process (GO:0090181)2.93416894
110glucose 6-phosphate metabolic process (GO:0051156)2.91575244
111regulation of defense response to virus by virus (GO:0050690)2.90605278
1122-oxoglutarate metabolic process (GO:0006103)2.89973181
113mast cell activation (GO:0045576)2.89538792
114regulation of myeloid leukocyte mediated immunity (GO:0002886)2.88761282
115positive regulation of triglyceride metabolic process (GO:0090208)2.86741093
116negative regulation of lymphocyte mediated immunity (GO:0002707)2.86311925
117mannose metabolic process (GO:0006013)2.86090564
118lipopolysaccharide-mediated signaling pathway (GO:0031663)2.86019133
119phospholipid homeostasis (GO:0055091)2.85553985
120monocarboxylic acid catabolic process (GO:0072329)2.85222548
121positive regulation of lipoprotein lipase activity (GO:0051006)2.84815171
122positive regulation of triglyceride lipase activity (GO:0061365)2.84815171
123reverse cholesterol transport (GO:0043691)2.83995955
124acetyl-CoA metabolic process (GO:0006084)2.83332580
125drug transmembrane transport (GO:0006855)2.81007323
126urea cycle (GO:0000050)2.80733341
127urea metabolic process (GO:0019627)2.80733341
128bile acid metabolic process (GO:0008206)2.79873202
129cellular modified amino acid catabolic process (GO:0042219)2.79002520
130plasma lipoprotein particle assembly (GO:0034377)2.77942571
131positive regulation of production of molecular mediator of immune response (GO:0002702)2.77824307
132positive thymic T cell selection (GO:0045059)2.76921977
133response to fluid shear stress (GO:0034405)2.76210857
134fatty acid transmembrane transport (GO:1902001)2.75473933
135microglial cell activation (GO:0001774)2.75188481
136positive regulation of lymphocyte mediated immunity (GO:0002708)2.73803190
137cholesterol homeostasis (GO:0042632)2.73196242
138carnitine metabolic process (GO:0009437)2.72358074
139regulation of protein activation cascade (GO:2000257)2.71656990
140pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.70721299
141antigen processing and presentation of endogenous antigen (GO:0019883)2.70558725
142triglyceride homeostasis (GO:0070328)2.70242055
143acylglycerol homeostasis (GO:0055090)2.70242055
144regulation of tolerance induction (GO:0002643)2.70219837
145bile acid and bile salt transport (GO:0015721)2.70176257
146antigen processing and presentation via MHC class Ib (GO:0002475)2.69957054
147aspartate family amino acid catabolic process (GO:0009068)2.69805395
148sterol homeostasis (GO:0055092)2.69306563
149negative regulation of interleukin-12 production (GO:0032695)2.69160736
150regulation of immunoglobulin production (GO:0002637)2.68806529
151ethanol oxidation (GO:0006069)2.68781321
152positive regulation of lipid catabolic process (GO:0050996)2.68694156
153regulation of sequestering of triglyceride (GO:0010889)2.68170328
154regulation of mast cell degranulation (GO:0043304)2.68046712
155response to type I interferon (GO:0034340)2.68028246
156regulation of triglyceride metabolic process (GO:0090207)2.67377072
157cellular extravasation (GO:0045123)2.67116349
158lymphocyte homeostasis (GO:0002260)2.66745206
159negative regulation of leukocyte mediated immunity (GO:0002704)2.66460724
160aromatic amino acid family metabolic process (GO:0009072)2.66190938
161protein-lipid complex assembly (GO:0065005)2.65841997
162regulation of necrotic cell death (GO:0010939)2.64538168
163cellular response to growth hormone stimulus (GO:0071378)2.64486545
164positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.63861166
165cellular response to type I interferon (GO:0071357)2.62578800
166type I interferon signaling pathway (GO:0060337)2.62578800
167regulation of cholesterol biosynthetic process (GO:0045540)2.62481598
168detection of biotic stimulus (GO:0009595)2.62352793
169response to interleukin-15 (GO:0070672)2.61978661
170positive regulation of leukocyte mediated immunity (GO:0002705)2.61112010
171positive regulation of steroid metabolic process (GO:0045940)2.60927966
172dopamine transport (GO:0015872)2.60775066
173regulation of complement activation (GO:0030449)2.60261342
174regulation of interferon-beta biosynthetic process (GO:0045357)2.59265938
175negative regulation of fibrinolysis (GO:0051918)2.59186085
176cholesterol efflux (GO:0033344)2.58538687
177positive regulation of fatty acid beta-oxidation (GO:0032000)2.58096795
178nitrogen cycle metabolic process (GO:0071941)2.57490855
179dicarboxylic acid biosynthetic process (GO:0043650)2.57427469
180regulation of dendritic cell antigen processing and presentation (GO:0002604)2.57274344
181transcytosis (GO:0045056)2.57248885
182negative regulation of lipase activity (GO:0060192)2.57018748
183carnitine shuttle (GO:0006853)2.56814220
184positive regulation of B cell activation (GO:0050871)2.56273813
185alpha-amino acid catabolic process (GO:1901606)2.55976596
186pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.55739629
187response to mercury ion (GO:0046689)2.55445740
188macrophage activation (GO:0042116)2.54418327
189positive regulation of adaptive immune response (GO:0002821)2.54183439
190low-density lipoprotein particle clearance (GO:0034383)2.54160525
191cholesterol catabolic process (GO:0006707)2.53777041
192sterol catabolic process (GO:0016127)2.53777041
193ethanol metabolic process (GO:0006067)2.53599973
194tricarboxylic acid metabolic process (GO:0072350)2.53283803
195cellular response to interferon-beta (GO:0035458)2.53089357
196negative regulation of alpha-beta T cell activation (GO:0046636)2.52954979
197positive regulation of T cell cytokine production (GO:0002726)2.52547971

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.15304671
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.58803994
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.48521600
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.22903818
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.81053030
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.66584384
7* FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.02236338
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.71125519
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.56337419
10GATA1_22025678_ChIP-Seq_K562_Human2.43739935
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.38855050
12CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.28453133
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.09597571
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00117307
15* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.98385192
16RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97528552
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88730724
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87991750
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85142028
20CLOCK_20551151_ChIP-Seq_293T_Human1.79308055
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79223350
22* LXR_22292898_ChIP-Seq_THP-1_Human1.76951313
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71886924
24MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71291620
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69788010
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69389615
27MAF_26560356_Chip-Seq_TH2_Human1.66566557
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.66177600
29* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.65109237
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64962408
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64459858
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.64176636
33* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62001051
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60107157
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58883531
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51098867
37SPI1_23547873_ChIP-Seq_NB4_Human1.51006991
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51001980
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48870303
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.47474474
41ELF1_20517297_ChIP-Seq_JURKAT_Human1.43802685
42* MYB_26560356_Chip-Seq_TH1_Human1.42578364
43BCL6_27268052_Chip-Seq_Bcells_Human1.41158973
44VDR_21846776_ChIP-Seq_THP-1_Human1.40604666
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.40526368
46* RACK7_27058665_Chip-Seq_MCF-7_Human1.40364404
47MYB_26560356_Chip-Seq_TH2_Human1.39806234
48* ELK3_25401928_ChIP-Seq_HUVEC_Human1.38655334
49* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37142173
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.36518884
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35234659
52CDX2_20551321_ChIP-Seq_CACO-2_Human1.34930234
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.34684278
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34558938
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34495881
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33329987
57P68_20966046_ChIP-Seq_HELA_Human1.33272620
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.30715095
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30262194
60P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30247996
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.29346740
62TBX20_22328084_ChIP-Seq_HEART_Mouse1.28932980
63TBX20_22080862_ChIP-Seq_HEART_Mouse1.28932980
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.28516438
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27297009
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.25793803
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24992718
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23912144
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23024522
70GATA1_19941826_ChIP-Seq_K562_Human1.21681714
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21067944
72TCF7_22412390_ChIP-Seq_EML_Mouse1.20982196
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20725457
74* KDM2B_26808549_Chip-Seq_DND41_Human1.20292501
75KDM2B_26808549_Chip-Seq_K562_Human1.20095770
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.20090472
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19672376
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18493533
79* MAF_26560356_Chip-Seq_TH1_Human1.18049186
80* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17425546
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17049636
82SCL_19346495_ChIP-Seq_HPC-7_Human1.16534860
83* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15838421
84BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.15377926
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14329965
86VDR_24763502_ChIP-Seq_THP-1_Human1.14172525
87TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13694058
88* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13461863
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13250721
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12549719
91* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12219471
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.11775444
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11451713
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10192346
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08829612
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07401776
97* GATA4_25053715_ChIP-Seq_YYC3_Human1.07145940
98* TET1_21451524_ChIP-Seq_MESCs_Mouse1.07131211
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06438072
100* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06436090
101GATA3_27048872_Chip-Seq_THYMUS_Human1.05515101
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03990776
103SMC4_20622854_ChIP-Seq_HELA_Human1.03592703
104LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03356533
105STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03257692
106RUNX_20019798_ChIP-Seq_JUKART_Human1.02999039
107CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02902579
108SPI1_20517297_ChIP-Seq_HL60_Human1.02244746
109GATA2_19941826_ChIP-Seq_K562_Human1.01423174
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01381473
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00777958
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00586369
113SA1_27219007_Chip-Seq_Bcells_Human0.99546188
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99520033
115* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99474513
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.99282887
117PHF8_20622854_ChIP-Seq_HELA_Human0.98985217
118FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98941179
119* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98139330
120* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95999049
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95787567
122SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94889076
123SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94855041
124GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94583084
125PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94558414
126GATA6_25053715_ChIP-Seq_YYC3_Human0.94423179
127PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94257939
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93673283
129MYC_22102868_ChIP-Seq_BL_Human0.93009846
130BCOR_27268052_Chip-Seq_Bcells_Human0.92093329
131SOX2_20726797_ChIP-Seq_SW620_Human0.91662021
132UTX_26944678_Chip-Seq_JUKART_Human0.91352521
133ZNF263_19887448_ChIP-Seq_K562_Human0.91081661
134* SA1_27219007_Chip-Seq_ERYTHROID_Human0.90493405
135* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90296524
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90157028
137MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90025971
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89774322
139CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89120522
140SPI1_23127762_ChIP-Seq_K562_Human0.88402154
141GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88334541
142TP63_22573176_ChIP-Seq_HFKS_Human0.87646315
143VDR_24787735_ChIP-Seq_THP-1_Human0.86567797
144VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86475360
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86216571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002132_abnormal_respiratory_system5.76505382
2MP0005360_urolithiasis4.37499148
3MP0002139_abnormal_hepatobiliary_system4.37037500
4MP0005365_abnormal_bile_salt3.82218145
5MP0009840_abnormal_foam_cell3.61023005
6MP0005085_abnormal_gallbladder_physiolo3.38852234
7MP0005058_abnormal_lysosome_morphology3.03147385
8MP0000858_altered_metastatic_potential2.96071797
9MP0005671_abnormal_response_to2.84996847
10MP0008875_abnormal_xenobiotic_pharmacok2.72817403
11MP0003252_abnormal_bile_duct2.52869981
12MP0005083_abnormal_biliary_tract2.50924221
13MP0001666_abnormal_nutrient_absorption2.46220578
14MP0003191_abnormal_cellular_cholesterol2.42951785
15MP0001873_stomach_inflammation2.40481792
16MP0002405_respiratory_system_inflammati2.32679772
17MP0005670_abnormal_white_adipose2.30512051
18MP0010329_abnormal_lipoprotein_level2.26070766
19MP0005451_abnormal_body_composition2.13979798
20MP0002452_abnormal_antigen_presenting1.98232859
21MP0002138_abnormal_hepatobiliary_system1.94680271
22MP0002420_abnormal_adaptive_immunity1.93513503
23MP0001819_abnormal_immune_cell1.92655760
24MP0005332_abnormal_amino_acid1.92107728
25MP0003195_calcinosis1.89542496
26MP0009643_abnormal_urine_homeostasis1.78488289
27MP0003300_gastrointestinal_ulcer1.77251653
28MP0004019_abnormal_vitamin_homeostasis1.76427957
29MP0005408_hypopigmentation1.74694337
30MP0002118_abnormal_lipid_homeostasis1.72236238
31MP0009333_abnormal_splenocyte_physiolog1.72162964
32MP0004883_abnormal_blood_vessel1.65029106
33MP0000609_abnormal_liver_physiology1.60734366
34MP0003806_abnormal_nucleotide_metabolis1.59026566
35MP0009278_abnormal_bone_marrow1.55223566
36MP0004510_myositis1.47212960
37MP0002398_abnormal_bone_marrow1.47121640
38MP0000716_abnormal_immune_system1.46820363
39MP0005666_abnormal_adipose_tissue1.45958849
40MP0003705_abnormal_hypodermis_morpholog1.43923314
41MP0002837_dystrophic_cardiac_calcinosis1.41392357
42MP0002998_abnormal_bone_remodeling1.38895080
43MP0000685_abnormal_immune_system1.34044345
44MP0000465_gastrointestinal_hemorrhage1.33836606
45MP0005319_abnormal_enzyme/_coenzyme1.32613647
46MP0001790_abnormal_immune_system1.29021603
47MP0005387_immune_system_phenotype1.29021603
48MP0003172_abnormal_lysosome_physiology1.28900376
49MP0001663_abnormal_digestive_system1.26149514
50MP0002796_impaired_skin_barrier1.25764037
51MP0002722_abnormal_immune_system1.23639277
52MP0005584_abnormal_enzyme/coenzyme_acti1.22559674
53MP0003724_increased_susceptibility_to1.21999134
54MP0003436_decreased_susceptibility_to1.19197966
55MP0000689_abnormal_spleen_morphology1.17457764
56MP0010368_abnormal_lymphatic_system1.16857026
57MP0004185_abnormal_adipocyte_glucose1.16233196
58MP0001756_abnormal_urination1.14147139
59MP0002429_abnormal_blood_cell1.13952033
60MP0005375_adipose_tissue_phenotype1.13428021
61MP0003303_peritoneal_inflammation1.12790048
62MP0004130_abnormal_muscle_cell1.12425778
63MP0004782_abnormal_surfactant_physiolog1.11002763
64MP0003453_abnormal_keratinocyte_physiol1.10445715
65MP0005167_abnormal_blood-brain_barrier1.10366660
66MP0004947_skin_inflammation1.09886937
67MP0000604_amyloidosis1.08908595
68MP0008961_abnormal_basal_metabolism1.08277523
69MP0008260_abnormal_autophagy1.08276418
70MP0008469_abnormal_protein_level1.07027993
71MP0001835_abnormal_antigen_presentation1.05774836
72MP0005164_abnormal_response_to1.05007364
73MP0001545_abnormal_hematopoietic_system1.03846271
74MP0005397_hematopoietic_system_phenotyp1.03846271
75MP0002933_joint_inflammation1.03792910
76MP0005636_abnormal_mineral_homeostasis1.03475646
77MP0003868_abnormal_feces_composition1.03460771
78MP0004381_abnormal_hair_follicle1.03429494
79MP0002254_reproductive_system_inflammat1.02715568
80MP0005464_abnormal_platelet_physiology1.01637797
81MP0002136_abnormal_kidney_physiology1.01478828
82MP0000703_abnormal_thymus_morphology1.01233830
83MP0000490_abnormal_crypts_of1.00848748
84MP0004043_abnormal_pH_regulation1.00838172
85MP0002971_abnormal_brown_adipose0.99571259
86MP0001851_eye_inflammation0.97553577
87MP0000767_abnormal_smooth_muscle0.97311233
88MP0001765_abnormal_ion_homeostasis0.96370811
89MP0005025_abnormal_response_to0.95135272
90MP0003566_abnormal_cell_adhesion0.94783732
91MP0003045_fibrosis0.94377015
92MP0005166_decreased_susceptibility_to0.93998355
93MP0009764_decreased_sensitivity_to0.92941309
94MP0010155_abnormal_intestine_physiology0.92583440
95MP0009379_abnormal_foot_pigmentation0.92530692
96MP0002060_abnormal_skin_morphology0.90888290
97MP0002148_abnormal_hypersensitivity_rea0.90819846
98MP0001915_intracranial_hemorrhage0.89477811
99MP0001845_abnormal_inflammatory_respons0.89145425
100MP0002166_altered_tumor_susceptibility0.87653008
101MP0005165_increased_susceptibility_to0.87593954
102MP0002419_abnormal_innate_immunity0.87124434
103MP0005334_abnormal_fat_pad0.86054617
104MP0005381_digestive/alimentary_phenotyp0.85888160
105MP0002098_abnormal_vibrissa_morphology0.85700313
106MP0008004_abnormal_stomach_pH0.85228229
107MP0002078_abnormal_glucose_homeostasis0.84785081
108MP0005220_abnormal_exocrine_pancreas0.84443952
109MP0008438_abnormal_cutaneous_collagen0.83731455
110MP0000598_abnormal_liver_morphology0.83707873
111MP0005084_abnormal_gallbladder_morpholo0.83236213
112MP0003011_delayed_dark_adaptation0.83089616
113MP0000749_muscle_degeneration0.82777932
114MP0006082_CNS_inflammation0.82580090
115MP0005076_abnormal_cell_differentiation0.81805059
116MP0001849_ear_inflammation0.81172111
117MP0000230_abnormal_systemic_arterial0.80756212
118MP0001800_abnormal_humoral_immune0.80736478
119MP0001853_heart_inflammation0.80040545
120MP0004036_abnormal_muscle_relaxation0.79414676
121MP0000343_altered_response_to0.79189697
122MP0005330_cardiomyopathy0.79153849
123MP0009642_abnormal_blood_homeostasis0.77701021
124MP0009785_altered_susceptibility_to0.77383401
125MP0003828_pulmonary_edema0.76315045
126MP0008874_decreased_physiological_sensi0.76248880
127MP0010234_abnormal_vibrissa_follicle0.75646657
128MP0000751_myopathy0.75038807
129MP0001533_abnormal_skeleton_physiology0.74852290
130MP0005310_abnormal_salivary_gland0.74730180
131MP0005000_abnormal_immune_tolerance0.74646331
132MP0003763_abnormal_thymus_physiology0.74067588
133MP0003075_altered_response_to0.73329289
134MP0001216_abnormal_epidermal_layer0.72640234
135MP0002723_abnormal_immune_serum0.71387464
136MP0009763_increased_sensitivity_to0.70849923
137MP0000249_abnormal_blood_vessel0.70178624
138MP0003329_amyloid_beta_deposits0.69105908
139MP0005275_abnormal_skin_tensile0.68729197
140MP0000383_abnormal_hair_follicle0.68372662
141MP0003690_abnormal_glial_cell0.67779016
142MP0003866_abnormal_defecation0.67678210
143MP0003183_abnormal_peptide_metabolism0.66470302
144MP0004084_abnormal_cardiac_muscle0.66394387
145MP0003279_aneurysm0.63848910
146MP0003448_altered_tumor_morphology0.63487761
147MP0005390_skeleton_phenotype0.61417633
148MP0000920_abnormal_myelination0.59880947
149MP0004858_abnormal_nervous_system0.58780485

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)7.12919117
2Elevated erythrocyte sedimentation rate (HP:0003565)5.52763027
3Myositis (HP:0100614)5.28079544
4Zonular cataract (HP:0010920)4.98386602
5Abnormality of pyrimidine metabolism (HP:0004353)4.69645407
6Xanthomatosis (HP:0000991)4.54000168
7Abnormality of macrophages (HP:0004311)4.51869875
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.25445875
9Recurrent abscess formation (HP:0002722)3.91901971
10Recurrent bacterial skin infections (HP:0005406)3.87084338
11Deep venous thrombosis (HP:0002625)3.74467986
12Hypoglycemic coma (HP:0001325)3.66445744
13Intrahepatic cholestasis (HP:0001406)3.64400116
14Systemic lupus erythematosus (HP:0002725)3.63536128
15Dysostosis multiplex (HP:0000943)3.62132771
16Thrombocytosis (HP:0001894)3.58273603
17Complement deficiency (HP:0004431)3.48904033
18Abnormality of T cell physiology (HP:0011840)3.46668788
19Hyperlipoproteinemia (HP:0010980)3.43759600
20Ketosis (HP:0001946)3.29806777
21Asymmetric septal hypertrophy (HP:0001670)3.21364846
22Obstructive sleep apnea (HP:0002870)3.20429571
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.11423369
24Abnormality of fatty-acid metabolism (HP:0004359)3.10014451
25Orchitis (HP:0100796)3.07907047
26Stridor (HP:0010307)3.05973388
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.05269952
28Diaphragmatic weakness (HP:0009113)3.03137044
29Ketoacidosis (HP:0001993)3.02761111
30Abnormality of monocarboxylic acid metabolism (HP:0010996)3.00932949
31Late onset (HP:0003584)2.98722013
32Generalized aminoaciduria (HP:0002909)2.97793376
33Neurofibrillary tangles (HP:0002185)2.97405064
34Meningitis (HP:0001287)2.91204939
35Abnormality of methionine metabolism (HP:0010901)2.90443736
36Hyperglycinuria (HP:0003108)2.88798493
37Abnormality of T cells (HP:0002843)2.86267228
38Recurrent fungal infections (HP:0002841)2.82635241
39Abnormality of complement system (HP:0005339)2.81415617
40Mucopolysacchariduria (HP:0008155)2.81283996
41Urinary glycosaminoglycan excretion (HP:0003541)2.81283996
42Hyperammonemia (HP:0001987)2.77377188
43Gout (HP:0001997)2.75847641
44Chronic obstructive pulmonary disease (HP:0006510)2.74517536
45Obstructive lung disease (HP:0006536)2.74517536
46Prolonged partial thromboplastin time (HP:0003645)2.73380743
47Vacuolated lymphocytes (HP:0001922)2.73368460
48Increased IgE level (HP:0003212)2.73162965
49Pustule (HP:0200039)2.72592284
50Optic neuritis (HP:0100653)2.69911722
51Retrobulbar optic neuritis (HP:0100654)2.69911722
52Hypergammaglobulinemia (HP:0010702)2.68072550
53Abnormality of serine family amino acid metabolism (HP:0010894)2.67126414
54Abnormality of glycine metabolism (HP:0010895)2.67126414
55Prolonged bleeding time (HP:0003010)2.66973256
56Increased serum ferritin (HP:0003281)2.66091892
57Abnormality of glutamine family amino acid metabolism (HP:0010902)2.65654678
58Hypercholesterolemia (HP:0003124)2.61423891
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.61072616
60Right ventricular cardiomyopathy (HP:0011663)2.60628774
61Abnormality of polysaccharide metabolism (HP:0011012)2.60507735
62Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60507735
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60507735
64Axonal loss (HP:0003447)2.59898124
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.59712928
66Gastrointestinal infarctions (HP:0005244)2.59333429
67Gingivitis (HP:0000230)2.57755035
68Cellulitis (HP:0100658)2.57246334
69J-shaped sella turcica (HP:0002680)2.57214505
70Abnormality of purine metabolism (HP:0004352)2.55856050
71Urticaria (HP:0001025)2.55746213
72Recurrent skin infections (HP:0001581)2.54764218
73Joint hemorrhage (HP:0005261)2.53249209
74Stomatitis (HP:0010280)2.52089846
75Cheilitis (HP:0100825)2.50295832
76Abnormality of the common coagulation pathway (HP:0010990)2.49511571
77Mediastinal lymphadenopathy (HP:0100721)2.49230519
78Glomerulonephritis (HP:0000099)2.47317134
79Encephalitis (HP:0002383)2.45873108
80Abnormality of dicarboxylic acid metabolism (HP:0010995)2.45389808
81Dicarboxylic aciduria (HP:0003215)2.45389808
82Epidermoid cyst (HP:0200040)2.45184959
83Hyperglycinemia (HP:0002154)2.40851200
84Purpura (HP:0000979)2.40832548
85Myocardial infarction (HP:0001658)2.40779006
86Vascular calcification (HP:0004934)2.40438241
87Megaloblastic anemia (HP:0001889)2.38879504
88Chest pain (HP:0100749)2.38154453
89Hypoalphalipoproteinemia (HP:0003233)2.38102219
90Poikilocytosis (HP:0004447)2.37690031
91Cerebral inclusion bodies (HP:0100314)2.35086561
92Vasculitis (HP:0002633)2.34148227
93Myoglobinuria (HP:0002913)2.31800838
94Abnormality of the intrinsic pathway (HP:0010989)2.31321540
95Fat malabsorption (HP:0002630)2.30266829
96Petechiae (HP:0000967)2.27531728
97Hypochromic anemia (HP:0001931)2.27230233
98Polycythemia (HP:0001901)2.24473920
99Epistaxis (HP:0000421)2.21155420
100Hypobetalipoproteinemia (HP:0003563)2.21092098
101Ventricular tachycardia (HP:0004756)2.18680190
102Abnormality of iron homeostasis (HP:0011031)2.18099466
103Interstitial pulmonary disease (HP:0006530)2.17965211
104Cardiovascular calcification (HP:0011915)2.17803458
105Gastrointestinal inflammation (HP:0004386)2.17045181
106Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.17041180
107Esophageal varix (HP:0002040)2.16290106
108Hyperinsulinemic hypoglycemia (HP:0000825)2.15923896
109Inflammation of the large intestine (HP:0002037)2.14592117
110Hypolipoproteinemia (HP:0010981)2.14404904
111Hemoptysis (HP:0002105)2.12977842
112Amyloidosis (HP:0011034)2.12752616
113Chronic mucocutaneous candidiasis (HP:0002728)2.10477738
114Recurrent cutaneous fungal infections (HP:0011370)2.10477738
115Hypertriglyceridemia (HP:0002155)2.10124113
116Increased cerebral lipofuscin (HP:0011813)2.08296595
117Arterial thrombosis (HP:0004420)2.05962461
118Mitral stenosis (HP:0001718)2.03578210
119Spinal muscular atrophy (HP:0007269)2.03361860
120Increased IgM level (HP:0003496)2.03351065
121Emphysema (HP:0002097)2.02343558
122Impaired platelet aggregation (HP:0003540)2.01336348
123Abnormal platelet function (HP:0011869)2.01336348
124Hypoglycemic seizures (HP:0002173)1.98858023
125Abnormality of nucleobase metabolism (HP:0010932)1.98042602
126Hemiplegia (HP:0002301)1.97924250
127Keratoconjunctivitis sicca (HP:0001097)1.97411675
128Nephritis (HP:0000123)1.97310306
129Pancreatitis (HP:0001733)1.97171127
130Increased neuronal autofluorescent lipopigment (HP:0002074)1.96967666
131Malnutrition (HP:0004395)1.96473133
132Joint stiffness (HP:0001387)1.94040367
133Hyporeflexia of lower limbs (HP:0002600)1.93793308
134Skin nodule (HP:0200036)1.92605250
135Conjugated hyperbilirubinemia (HP:0002908)1.92593725
136Hyperbilirubinemia (HP:0002904)1.92312650
137Pulmonary infiltrates (HP:0002113)1.91923777
138Erythema (HP:0010783)1.91787095
139Metabolic acidosis (HP:0001942)1.88774043
140Protuberant abdomen (HP:0001538)1.88575367
141Osteomyelitis (HP:0002754)1.88499947
142Eczematoid dermatitis (HP:0000976)1.87290387
143Agammaglobulinemia (HP:0004432)1.87138682
144Premature loss of primary teeth (HP:0006323)1.87020122
145Cerebral aneurysm (HP:0004944)1.86736242
146Abnormality of T cell number (HP:0011839)1.86517463
147Alkalosis (HP:0001948)1.86278064
148Hemorrhage of the eye (HP:0011885)1.85585796
149Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85213588
150Abnormality of liposaccharide metabolism (HP:0010968)1.84799302
151Abnormality of glycosphingolipid metabolism (HP:0004343)1.84799302
152Abnormality of glycolipid metabolism (HP:0010969)1.84799302
153Proximal tubulopathy (HP:0000114)1.84712586
154Abnormality of urine glucose concentration (HP:0011016)1.83683532
155Glycosuria (HP:0003076)1.83683532
156Recurrent viral infections (HP:0004429)1.82084863
157Spontaneous hematomas (HP:0007420)1.81785483
158Increased purine levels (HP:0004368)1.80578664
159Hyperuricemia (HP:0002149)1.80578664
160Hypochromic microcytic anemia (HP:0004840)1.80063790
161Fatigue (HP:0012378)1.79865528
162Gingival bleeding (HP:0000225)1.79814474
163Gastrointestinal stroma tumor (HP:0100723)1.76878858
164Recurrent gram-negative bacterial infections (HP:0005420)1.76458264
165Abdominal distention (HP:0003270)1.76064512
166Sudden death (HP:0001699)1.75514763
167Keratoconjunctivitis (HP:0001096)1.74785124
168Alopecia of scalp (HP:0002293)1.74732142
169T lymphocytopenia (HP:0005403)1.73979503
170Ileus (HP:0002595)1.73914521
171Abnormality of the pancreatic islet cells (HP:0006476)1.73769287
172Abnormality of endocrine pancreas physiology (HP:0012093)1.73769287
173Pulmonary embolism (HP:0002204)1.72246978
174Hematuria (HP:0000790)1.71049954
175Autoimmune thrombocytopenia (HP:0001973)1.70728579
176Leukocytosis (HP:0001974)1.70149478
177Steatorrhea (HP:0002570)1.69227607
178Hypokalemic alkalosis (HP:0001949)1.68590668
179Hepatocellular carcinoma (HP:0001402)1.68166321
180Colitis (HP:0002583)1.67097681
181Abnormality of the nasal mucosa (HP:0000433)1.66498720
182Vomiting (HP:0002013)1.65820084

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.83165625
2BCKDK3.00107386
3RIPK42.91165249
4EPHB12.89795310
5TRIB32.87381973
6TGFBR22.61925265
7PRPF4B2.55409346
8MAP4K12.32903977
9FGFR42.31218410
10SIK12.30449339
11TAOK32.28653383
12FES2.08899355
13MET1.96223149
14PRKG21.94143278
15TYK21.88031299
16WNK41.85242781
17PKN21.84101348
18MAPK71.79701671
19INSRR1.77254719
20TNK21.75386610
21TTN1.74338834
22MAP3K101.74177501
23TBK11.73056669
24BMX1.70364713
25MAP2K21.66418123
26PTK61.64372460
27TAOK11.52271616
28PAK41.37114425
29CSF1R1.35838940
30IRAK31.33121059
31TIE11.32026542
32LRRK21.27045927
33MST1R1.24960338
34ZAP701.24084074
35STK101.23813812
36MAPK151.22583498
37STK391.21702654
38MAP3K31.21678590
39MAP3K71.20365429
40TESK21.19768139
41CAMK1D1.19606438
42MAP2K31.17571995
43JAK11.14756012
44JAK21.12183497
45EPHA31.12015339
46CSK1.09837446
47SMG11.07347188
48IKBKE1.03773040
49JAK31.03772047
50CDK41.02790972
51MAP3K131.02004310
52BLK1.01870243
53TAOK21.01852039
54MAP3K141.00027609
55BTK0.99740626
56TXK0.98956334
57GRK60.98784889
58KDR0.98594787
59CAMK1G0.97618571
60EEF2K0.96927505
61CDC42BPA0.95938275
62LYN0.95804694
63DMPK0.95091255
64PTK20.94684030
65PIK3CG0.93061205
66SIK30.92737738
67MAP3K20.90578237
68PIM10.90375891
69MAPK110.87797765
70PRKD10.87320496
71HIPK20.85640189
72RIPK10.81269086
73ITK0.80433378
74MAP3K10.77320587
75DYRK1B0.76250259
76MAP3K120.75879681
77NLK0.75674863
78CLK10.74175353
79FGR0.74130159
80PRKD20.73963545
81MYLK0.71986651
82PDPK10.71885273
83PRKAA20.70509046
84LMTK20.68898684
85FLT30.67210127
86MAP3K110.65216672
87GSK3A0.65097714
88MAPK120.64712326
89PTK2B0.64643991
90IKBKB0.64110352
91PDGFRB0.63469790
92TESK10.62394969
93STK380.62363163
94IRAK20.61131957
95PKN10.59268986
96OBSCN0.58977164
97SIK20.58853865
98OXSR10.58767990
99FYN0.57652482
100MATK0.57109308
101PDK10.56990522
102GRK70.56670453
103RET0.56555270
104NME20.55330441
105MARK30.52734802
106NEK90.52478418
107KSR20.52309731
108PHKG10.51775803
109PHKG20.51775803
110ILK0.51411697
111PRKCZ0.50671212
112HCK0.49825181
113MAPK40.49067640
114LCK0.49066192
115PRKCH0.48133553
116PRKCQ0.47157753
117KIT0.46700766
118FGFR30.46513567
119RPS6KC10.46094973
120RPS6KL10.46094973
121EPHB20.43960669
122IRAK40.43776579
123LATS10.43231687
124ICK0.43076400
125MARK20.42015549
126RPS6KA60.41786253
127SYK0.39968335
128EGFR0.39024243
129RPS6KA20.38994495
130TEC0.38483999
131MTOR0.37783503
132MAP3K60.37385136
133CHUK0.37135127
134WNK10.37054857
135EPHA20.33697711
136MAP2K60.31245585
137CAMKK10.29921001

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.23605577
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.85959782
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.70076161
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.63551340
5Fatty acid degradation_Homo sapiens_hsa000712.53601244
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42581339
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.39467192
8Allograft rejection_Homo sapiens_hsa053302.38474710
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.36176349
10Tryptophan metabolism_Homo sapiens_hsa003802.25635888
11Autoimmune thyroid disease_Homo sapiens_hsa053202.25051073
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.23375848
13Nitrogen metabolism_Homo sapiens_hsa009102.22020228
14Antigen processing and presentation_Homo sapiens_hsa046122.21976354
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.15090522
16Malaria_Homo sapiens_hsa051442.06006802
17Propanoate metabolism_Homo sapiens_hsa006402.05529913
18Viral myocarditis_Homo sapiens_hsa054162.03680426
19PPAR signaling pathway_Homo sapiens_hsa033202.01990247
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96067441
21Fat digestion and absorption_Homo sapiens_hsa049751.94099112
22Fatty acid metabolism_Homo sapiens_hsa012121.88289135
23Staphylococcus aureus infection_Homo sapiens_hsa051501.86323010
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.84737070
25Arginine biosynthesis_Homo sapiens_hsa002201.83623515
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82742229
27Complement and coagulation cascades_Homo sapiens_hsa046101.79093420
28Histidine metabolism_Homo sapiens_hsa003401.76641289
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.76205800
30Selenocompound metabolism_Homo sapiens_hsa004501.69738872
31T cell receptor signaling pathway_Homo sapiens_hsa046601.69417024
32Peroxisome_Homo sapiens_hsa041461.69290152
33Sulfur metabolism_Homo sapiens_hsa009201.64756153
34Type I diabetes mellitus_Homo sapiens_hsa049401.64297374
35Other glycan degradation_Homo sapiens_hsa005111.62959511
36Butanoate metabolism_Homo sapiens_hsa006501.62668186
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57379586
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56072143
39Fatty acid elongation_Homo sapiens_hsa000621.55941609
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55087511
41beta-Alanine metabolism_Homo sapiens_hsa004101.53475861
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53227068
43Caffeine metabolism_Homo sapiens_hsa002321.51075845
44Starch and sucrose metabolism_Homo sapiens_hsa005001.46777951
45Tuberculosis_Homo sapiens_hsa051521.44265874
46Linoleic acid metabolism_Homo sapiens_hsa005911.44026444
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39237274
48Hematopoietic cell lineage_Homo sapiens_hsa046401.36515011
49ABC transporters_Homo sapiens_hsa020101.35948321
50VEGF signaling pathway_Homo sapiens_hsa043701.31911343
51Steroid biosynthesis_Homo sapiens_hsa001001.31565086
52Measles_Homo sapiens_hsa051621.28590802
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.22300569
54Chemokine signaling pathway_Homo sapiens_hsa040621.20436267
55Bile secretion_Homo sapiens_hsa049761.19344927
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.18639408
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17750844
58Chemical carcinogenesis_Homo sapiens_hsa052041.16377427
59TNF signaling pathway_Homo sapiens_hsa046681.15940042
60Lysine degradation_Homo sapiens_hsa003101.14708966
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12552638
62Phenylalanine metabolism_Homo sapiens_hsa003601.10330438
63Asthma_Homo sapiens_hsa053101.08748100
64Influenza A_Homo sapiens_hsa051641.08706392
65Vitamin digestion and absorption_Homo sapiens_hsa049771.08347960
66Sulfur relay system_Homo sapiens_hsa041221.06183181
67Lysosome_Homo sapiens_hsa041421.06000506
68NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05791597
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04554333
70Glycerolipid metabolism_Homo sapiens_hsa005611.04193082
71Platelet activation_Homo sapiens_hsa046111.01981400
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.99843518
73Rheumatoid arthritis_Homo sapiens_hsa053230.99761293
74Pyruvate metabolism_Homo sapiens_hsa006200.99738759
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99175909
76Retinol metabolism_Homo sapiens_hsa008300.98148710
77Herpes simplex infection_Homo sapiens_hsa051680.96167063
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95674922
79Carbon metabolism_Homo sapiens_hsa012000.94152432
80Non-small cell lung cancer_Homo sapiens_hsa052230.94083898
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.93909103
82Folate biosynthesis_Homo sapiens_hsa007900.91678046
83Choline metabolism in cancer_Homo sapiens_hsa052310.89895684
84Chronic myeloid leukemia_Homo sapiens_hsa052200.88081371
85Phagosome_Homo sapiens_hsa041450.88033958
86Hepatitis C_Homo sapiens_hsa051600.87874858
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.86213999
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85050347
89Apoptosis_Homo sapiens_hsa042100.84354840
90African trypanosomiasis_Homo sapiens_hsa051430.84313431
91Insulin resistance_Homo sapiens_hsa049310.80135863
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79813513
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.79670447
94Arginine and proline metabolism_Homo sapiens_hsa003300.79617216
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78446579
96Hepatitis B_Homo sapiens_hsa051610.78314699
97Arachidonic acid metabolism_Homo sapiens_hsa005900.77327589
98Pancreatic cancer_Homo sapiens_hsa052120.77162121
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76101657
100GnRH signaling pathway_Homo sapiens_hsa049120.75764682
101Tyrosine metabolism_Homo sapiens_hsa003500.72650878
102Legionellosis_Homo sapiens_hsa051340.72623562
103Ether lipid metabolism_Homo sapiens_hsa005650.72602050
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.72564498
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.72022302
106Renal cell carcinoma_Homo sapiens_hsa052110.69592467
107Renin-angiotensin system_Homo sapiens_hsa046140.69337935
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.68918312
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67080877
110Galactose metabolism_Homo sapiens_hsa000520.66543257
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66319658
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65746741
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64205893
114Prolactin signaling pathway_Homo sapiens_hsa049170.61477546
115Salmonella infection_Homo sapiens_hsa051320.60575231
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58570300
117Endocytosis_Homo sapiens_hsa041440.58322986
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.57765886
119HTLV-I infection_Homo sapiens_hsa051660.57197491
120HIF-1 signaling pathway_Homo sapiens_hsa040660.56938444
121Shigellosis_Homo sapiens_hsa051310.56162371
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.56092280
123Rap1 signaling pathway_Homo sapiens_hsa040150.55265266
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.55060479
125Epstein-Barr virus infection_Homo sapiens_hsa051690.54678419
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54354171
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53708048
128Glutathione metabolism_Homo sapiens_hsa004800.53105189
129Pancreatic secretion_Homo sapiens_hsa049720.52903571
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52546631
131Protein digestion and absorption_Homo sapiens_hsa049740.51695604
132Insulin signaling pathway_Homo sapiens_hsa049100.49016242
133Fatty acid biosynthesis_Homo sapiens_hsa000610.48880830
134Biosynthesis of amino acids_Homo sapiens_hsa012300.48496999
135Primary immunodeficiency_Homo sapiens_hsa053400.48359455
136Estrogen signaling pathway_Homo sapiens_hsa049150.47546160
137Fructose and mannose metabolism_Homo sapiens_hsa000510.47539426
138Endometrial cancer_Homo sapiens_hsa052130.46985561
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.46835865
140Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46696421
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46167843
142MAPK signaling pathway_Homo sapiens_hsa040100.46012032
143Bladder cancer_Homo sapiens_hsa052190.44677722
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44425441
145Pentose phosphate pathway_Homo sapiens_hsa000300.43744497
146FoxO signaling pathway_Homo sapiens_hsa040680.43098146
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41742995
148B cell receptor signaling pathway_Homo sapiens_hsa046620.40038390
149mTOR signaling pathway_Homo sapiens_hsa041500.37829052
150Osteoclast differentiation_Homo sapiens_hsa043800.37200575
151Pertussis_Homo sapiens_hsa051330.36823544
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35998969
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35660640
154Amoebiasis_Homo sapiens_hsa051460.35399194
155Notch signaling pathway_Homo sapiens_hsa043300.34475525
156Viral carcinogenesis_Homo sapiens_hsa052030.32486979
157NF-kappa B signaling pathway_Homo sapiens_hsa040640.31976455
158Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31770839
159Type II diabetes mellitus_Homo sapiens_hsa049300.31492286
160Colorectal cancer_Homo sapiens_hsa052100.30907519
161Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30669936
162Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30255990
163Acute myeloid leukemia_Homo sapiens_hsa052210.29434314
164Focal adhesion_Homo sapiens_hsa045100.27802088
165Leishmaniasis_Homo sapiens_hsa051400.26597643
166Metabolic pathways_Homo sapiens_hsa011000.26075792
167Toxoplasmosis_Homo sapiens_hsa051450.25028437
168Prion diseases_Homo sapiens_hsa050200.22975181
169Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22334420

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