RNY4P13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mucosal immune response (GO:0002385)8.83159995
2negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)8.57282251
3antibacterial humoral response (GO:0019731)8.18589239
4organ or tissue specific immune response (GO:0002251)8.06741556
5nucleosome assembly (GO:0006334)7.89340278
6molting cycle (GO:0042303)7.81854407
7hair cycle (GO:0042633)7.81854407
8antimicrobial humoral response (GO:0019730)7.51020179
9protein-DNA complex assembly (GO:0065004)6.87074797
10nucleosome organization (GO:0034728)6.31751729
11protein-DNA complex subunit organization (GO:0071824)5.66406876
12CENP-A containing nucleosome assembly (GO:0034080)5.42095571
13regulation of megakaryocyte differentiation (GO:0045652)5.36659760
14negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.22380580
15epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.20228250
16chromatin remodeling at centromere (GO:0031055)5.03099526
17natural killer cell mediated cytotoxicity (GO:0042267)5.02176204
18natural killer cell mediated immunity (GO:0002228)5.02176204
19histone lysine demethylation (GO:0070076)4.97631096
20T cell mediated immunity (GO:0002456)4.78188006
21otic vesicle formation (GO:0030916)4.77144007
22histone demethylation (GO:0016577)4.70767286
23mesonephros development (GO:0001823)4.68438507
24chromatin assembly or disassembly (GO:0006333)4.51432969
25viral mRNA export from host cell nucleus (GO:0046784)4.41659134
26protein demethylation (GO:0006482)4.27920700
27protein dealkylation (GO:0008214)4.27920700
28chromatin assembly (GO:0031497)4.18038671
29venous blood vessel morphogenesis (GO:0048845)4.17384243
30regulation of mammary gland epithelial cell proliferation (GO:0033599)4.13133834
31regulation of histone H3-K9 methylation (GO:0051570)4.06540077
32histone exchange (GO:0043486)4.05045519
33protein localization to chromosome, centromeric region (GO:0071459)3.94776774
34regulation of B cell receptor signaling pathway (GO:0050855)3.80878624
35protein prenylation (GO:0018342)3.69116767
36prenylation (GO:0097354)3.69116767
37regulation of somitogenesis (GO:0014807)3.67005256
38defense response to Gram-positive bacterium (GO:0050830)3.64666236
39transcription elongation from RNA polymerase I promoter (GO:0006362)3.62888185
40regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.60663133
41V(D)J recombination (GO:0033151)3.56605141
42regulation of hematopoietic progenitor cell differentiation (GO:1901532)3.52638461
43termination of RNA polymerase I transcription (GO:0006363)3.45732361
44regulation of DNA damage checkpoint (GO:2000001)3.44651055
45positive regulation of mitotic sister chromatid separation (GO:1901970)3.42213612
46positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.42213612
47positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.42213612
48DNA replication-independent nucleosome organization (GO:0034724)3.40636379
49DNA replication-independent nucleosome assembly (GO:0006336)3.40636379
50cytolysis (GO:0019835)3.33474956
51telomere maintenance (GO:0000723)3.32230068
52embryonic hindlimb morphogenesis (GO:0035116)3.30332225
53response to UV-C (GO:0010225)3.29259298
54telomere organization (GO:0032200)3.29060245
55trophoblast giant cell differentiation (GO:0060707)3.24895042
56regulation of histone H3-K27 methylation (GO:0061085)3.21422619
57regulation of gene silencing (GO:0060968)3.20008102
58mammary gland alveolus development (GO:0060749)3.18700228
59regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.18313235
60positive regulation of granulocyte differentiation (GO:0030854)3.09317006
61nuclear pore complex assembly (GO:0051292)3.00667051
62regulation of DNA endoreduplication (GO:0032875)2.99372241
63transcription initiation from RNA polymerase I promoter (GO:0006361)2.97886763
64outer ear morphogenesis (GO:0042473)2.96701560
65generation of neurons (GO:0048699)2.94130619
66pharyngeal system development (GO:0060037)2.93864617
67negative regulation of smoothened signaling pathway (GO:0045879)2.90603768
68protein localization to kinetochore (GO:0034501)2.90602003
69regulation of sister chromatid segregation (GO:0033045)2.87864781
70regulation of mitotic sister chromatid separation (GO:0010965)2.87864781
71regulation of mitotic sister chromatid segregation (GO:0033047)2.87864781
72hindlimb morphogenesis (GO:0035137)2.81045349
73leukocyte mediated cytotoxicity (GO:0001909)2.79602935
74nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.78749524
75mitotic sister chromatid cohesion (GO:0007064)2.77409630
76forebrain morphogenesis (GO:0048853)2.72495688
77pseudouridine synthesis (GO:0001522)2.70248668
78regulation of centrosome cycle (GO:0046605)2.70152530
79protein polyglutamylation (GO:0018095)2.69067878
80intestinal epithelial cell development (GO:0060576)2.67960129
81nuclear pore organization (GO:0006999)2.63942521
82regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.63770042
83branching involved in mammary gland duct morphogenesis (GO:0060444)2.63133869
84regulation of mitotic metaphase/anaphase transition (GO:0030071)2.62881439
85regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.62881439
86spindle checkpoint (GO:0031577)2.61521259
87histone H3-K36 demethylation (GO:0070544)2.59323434
88thyroid gland development (GO:0030878)2.57402286
89embryonic forelimb morphogenesis (GO:0035115)2.52294092
90negative regulation of cardiac muscle tissue development (GO:0055026)2.52169855
91regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.51681245
92sprouting angiogenesis (GO:0002040)2.51216517
93regulation of chromosome segregation (GO:0051983)2.49258020
94mitotic spindle assembly checkpoint (GO:0007094)2.48831365
95DNA integration (GO:0015074)2.48306531
96lymphangiogenesis (GO:0001946)2.48091052
97negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.46657701
98DNA replication-dependent nucleosome organization (GO:0034723)13.5611325
99DNA replication-dependent nucleosome assembly (GO:0006335)13.5611325
100innate immune response in mucosa (GO:0002227)10.5394038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.50869065
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.12812450
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51697468
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.03266781
5E2F7_22180533_ChIP-Seq_HELA_Human2.58629125
6POU5F1_16153702_ChIP-ChIP_HESCs_Human2.55658138
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.33057204
8RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.19762031
9SOX2_16153702_ChIP-ChIP_HESCs_Human2.10013041
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse19.9247322
11FOXM1_23109430_ChIP-Seq_U2OS_Human1.87224095
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86646590
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80891174
14MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64981877
15E2F1_21310950_ChIP-Seq_MCF-7_Human1.54445723
16IRF1_19129219_ChIP-ChIP_H3396_Human1.50889833
17CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.48244267
18HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33590576
19SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.29072956
20NANOG_16153702_ChIP-ChIP_HESCs_Human1.22628839
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13833304
22ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12564740
23VDR_23849224_ChIP-Seq_CD4+_Human1.08433422
24POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06979525
25AR_21572438_ChIP-Seq_LNCaP_Human1.04085135
26AR_21909140_ChIP-Seq_LNCAP_Human1.00896331
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00100938
28ELK1_19687146_ChIP-ChIP_HELA_Human0.99755524
29ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98086374
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97720431
31KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97369373
32VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95195343
33PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94957282
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.93751511
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92526997
36NELFA_20434984_ChIP-Seq_ESCs_Mouse0.85357792
37ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83530450
38GATA1_22025678_ChIP-Seq_K562_Human0.79515871
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.79447660
40MYC_18940864_ChIP-ChIP_HL60_Human0.77627745
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76482033
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76007763
43HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74275888
44SOX2_18555785_ChIP-Seq_MESCs_Mouse0.74221243
45MYC_19030024_ChIP-ChIP_MESCs_Mouse0.73783974
46NOTCH1_21737748_ChIP-Seq_TLL_Human0.72865872
47ESR1_15608294_ChIP-ChIP_MCF-7_Human0.72654825
48STAT4_19710469_ChIP-ChIP_TH1__Mouse0.70828164
49TDRD3_21172665_ChIP-Seq_MCF-7_Human0.70015819
50ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69738925
51PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.69565373
52PKCTHETA_26484144_Chip-Seq_BREAST_Human0.65655143
53PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.65519584
54SOX2_18692474_ChIP-Seq_MESCs_Mouse0.64907646
55TCF3_18692474_ChIP-Seq_MESCs_Mouse0.61570828
56SALL4_22934838_ChIP-ChIP_CD34+_Human0.60806135
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.57491224
58FOXP3_21729870_ChIP-Seq_TREG_Human0.54311087
59POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.53373103
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.50995009
61EWS_26573619_Chip-Seq_HEK293_Human0.50138591
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.49384349
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.48461337
64STAT6_21828071_ChIP-Seq_BEAS2B_Human0.48184035
65VDR_21846776_ChIP-Seq_THP-1_Human0.47675433
66GATA3_27048872_Chip-Seq_THYMUS_Human0.47581565
67CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.46749115
68EED_16625203_ChIP-ChIP_MESCs_Mouse0.46574292
69BRD4_27068464_Chip-Seq_AML-cells_Mouse0.46411000
70DCP1A_22483619_ChIP-Seq_HELA_Human0.46147417
71IGF1R_20145208_ChIP-Seq_DFB_Human0.45868157
72TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.44725340
73MYB_26560356_Chip-Seq_TH2_Human0.42860070
74MYC_18555785_ChIP-Seq_MESCs_Mouse0.42627206
75ER_23166858_ChIP-Seq_MCF-7_Human0.42330935
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.42092942
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.41566227
78CIITA_25753668_ChIP-Seq_RAJI_Human0.40496252
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.39923237
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.39860921
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.38538018
82FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.38367029
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.38365434
84NANOG_21062744_ChIP-ChIP_HESCs_Human0.38105758
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.38003745
86RUNX_20019798_ChIP-Seq_JUKART_Human0.37961845
87MYB_26560356_Chip-Seq_TH1_Human0.37371199
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.35127409
89SOX17_20123909_ChIP-Seq_XEN_Mouse0.34658499
90SOX9_26525672_Chip-Seq_HEART_Mouse0.31651969
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.31582284
92ZNF274_21170338_ChIP-Seq_K562_Hela0.31415706
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.30911221
94AHR_22903824_ChIP-Seq_MCF-7_Human0.30449981
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.30136774
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.30136774
97THAP11_20581084_ChIP-Seq_MESCs_Mouse0.29701776
98SMAD_19615063_ChIP-ChIP_OVARY_Human0.29593028
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.28562191
100KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.27420968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system5.89975717
2MP0005083_abnormal_biliary_tract4.61605314
3MP0002160_abnormal_reproductive_system4.58007705
4MP0000569_abnormal_digit_pigmentation4.44750226
5MP0003693_abnormal_embryo_hatching3.85520511
6MP0002254_reproductive_system_inflammat3.52337610
7MP0000678_abnormal_parathyroid_gland3.24895843
8MP0010094_abnormal_chromosome_stability3.24298841
9MP0004381_abnormal_hair_follicle3.00208435
10MP0002396_abnormal_hematopoietic_system2.99424428
11MP0008057_abnormal_DNA_replication2.75620454
12MP0005389_reproductive_system_phenotype2.75058162
13MP0003111_abnormal_nucleus_morphology2.47069031
14MP0003763_abnormal_thymus_physiology2.43999860
15MP0004957_abnormal_blastocyst_morpholog2.36483023
16MP0001243_abnormal_dermal_layer2.33114820
17MP0003077_abnormal_cell_cycle2.26461902
18MP0000685_abnormal_immune_system2.01612156
19MP0003252_abnormal_bile_duct2.00622981
20MP0004134_abnormal_chest_morphology1.82455257
21MP0009250_abnormal_appendicular_skeleto1.80158666
22MP0002009_preneoplasia1.78199716
23MP0000703_abnormal_thymus_morphology1.57609347
24MP0001270_distended_abdomen1.56295808
25MP0001348_abnormal_lacrimal_gland1.49663564
26MP0006035_abnormal_mitochondrial_morpho1.43453876
27MP0005076_abnormal_cell_differentiation1.40408301
28MP0002928_abnormal_bile_duct1.38211722
29MP0005645_abnormal_hypothalamus_physiol1.33175427
30MP0000049_abnormal_middle_ear1.28599957
31MP0003942_abnormal_urinary_system1.28062187
32MP0002249_abnormal_larynx_morphology1.27599896
33MP0002139_abnormal_hepatobiliary_system1.25903892
34MP0003890_abnormal_embryonic-extraembry1.25144829
35MP0005671_abnormal_response_to1.24185620
36MP0000733_abnormal_muscle_development1.20917652
37MP0010307_abnormal_tumor_latency1.19440544
38MP0005075_abnormal_melanosome_morpholog1.17295010
39MP0005503_abnormal_tendon_morphology1.16893247
40MP0002405_respiratory_system_inflammati1.15250130
41MP0000350_abnormal_cell_proliferation1.13997992
42MP0001119_abnormal_female_reproductive1.12614547
43MP0008058_abnormal_DNA_repair1.10915403
44MP0001919_abnormal_reproductive_system1.09234390
45MP0002822_catalepsy1.08428020
46MP0008932_abnormal_embryonic_tissue1.08168735
47MP0002127_abnormal_cardiovascular_syste1.05003024
48MP0002876_abnormal_thyroid_physiology1.03779943
49MP0002722_abnormal_immune_system1.03391888
50MP0001216_abnormal_epidermal_layer1.00182064
51MP0003935_abnormal_craniofacial_develop1.00046359
52MP0003950_abnormal_plasma_membrane0.99770262
53MP0001697_abnormal_embryo_size0.97989584
54MP0004197_abnormal_fetal_growth/weight/0.96117480
55MP0000358_abnormal_cell_content/0.95255639
56MP0003806_abnormal_nucleotide_metabolis0.94830483
57MP0003937_abnormal_limbs/digits/tail_de0.93914668
58MP0000681_abnormal_thyroid_gland0.92185639
59MP0002398_abnormal_bone_marrow0.91825804
60MP0002971_abnormal_brown_adipose0.91392461
61MP0000689_abnormal_spleen_morphology0.90528075
62MP0001529_abnormal_vocalization0.89956987
63MP0002166_altered_tumor_susceptibility0.88590359
64MP0000383_abnormal_hair_follicle0.85754019
65MP0000631_abnormal_neuroendocrine_gland0.85566156
66MP0000762_abnormal_tongue_morphology0.84276058
67MP0002086_abnormal_extraembryonic_tissu0.82389058
68MP0000428_abnormal_craniofacial_morphol0.82125571
69MP0009697_abnormal_copulation0.82039666
70MP0004264_abnormal_extraembryonic_tissu0.81712820
71MP0000371_diluted_coat_color0.80632903
72MP0000534_abnormal_ureter_morphology0.78598853
73MP0008877_abnormal_DNA_methylation0.78093118
74MP0002837_dystrophic_cardiac_calcinosis0.77615630
75MP0001800_abnormal_humoral_immune0.77258685
76MP0001929_abnormal_gametogenesis0.74947053
77MP0009780_abnormal_chondrocyte_physiolo0.73592591
78MP0004808_abnormal_hematopoietic_stem0.71845413
79MP0000313_abnormal_cell_death0.71570867
80MP0001340_abnormal_eyelid_morphology0.71477941
81MP0001542_abnormal_bone_strength0.70281725
82MP0002111_abnormal_tail_morphology0.68636594
83MP0003315_abnormal_perineum_morphology0.68416178
84MP0001879_abnormal_lymphatic_vessel0.68056102
85MP0001145_abnormal_male_reproductive0.67127236
86MP0002060_abnormal_skin_morphology0.66266104
87MP0002877_abnormal_melanocyte_morpholog0.62902269
88MP0002116_abnormal_craniofacial_bone0.62891334
89MP0002108_abnormal_muscle_morphology0.62497537
90MP0002089_abnormal_postnatal_growth/wei0.62472521
91MP0002210_abnormal_sex_determination0.62169379
92MP0000653_abnormal_sex_gland0.62073557
93MP0000716_abnormal_immune_system0.61962811
94MP0000367_abnormal_coat/_hair0.61557636
95MP0005174_abnormal_tail_pigmentation0.61108289
96MP0003936_abnormal_reproductive_system0.61055280
97MP0002177_abnormal_outer_ear0.59704896
98MP0000427_abnormal_hair_cycle0.59282864
99MP0000627_abnormal_mammary_gland0.58442369
100MP0002115_abnormal_skeleton_extremities0.58159247

Predicted human phenotypes

RankGene SetZ-score
1Neoplasm of the heart (HP:0100544)8.39207115
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)7.64487303
3Short 4th metacarpal (HP:0010044)7.64487303
4Medulloblastoma (HP:0002885)6.91209961
5Abnormality of the parietal bone (HP:0002696)6.82968858
6Down-sloping shoulders (HP:0200021)6.81649847
7Short phalanx of the thumb (HP:0009660)5.88640824
8Deformed sella turcica (HP:0002681)5.80030805
9Abnormality of the 4th metacarpal (HP:0010012)5.45754713
10Milia (HP:0001056)4.77038674
11Neoplasm of the oral cavity (HP:0100649)4.71353076
12Supernumerary ribs (HP:0005815)4.55757905
13Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.52439107
14Abnormality of the distal phalanx of the thumb (HP:0009617)4.47100491
15Neoplasm of striated muscle (HP:0009728)4.21849913
16Supernumerary bones of the axial skeleton (HP:0009144)4.15037628
17Abnormality of the sella turcica (HP:0002679)4.10242265
18Oral leukoplakia (HP:0002745)4.05113591
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.92795399
20Basal cell carcinoma (HP:0002671)3.81949926
21Abnormal hand bone ossification (HP:0010660)3.67903868
22Abnormality of the preputium (HP:0100587)3.64779421
23Skin pits (HP:0100276)3.56710782
24Chromsome breakage (HP:0040012)3.55316099
25B lymphocytopenia (HP:0010976)3.51338069
26Aplasia/Hypoplasia of the uvula (HP:0010293)3.45139370
27Hemivertebrae (HP:0002937)3.39446726
28Abnormality of chromosome stability (HP:0003220)3.38873054
29Abnormal ossification of hand bones (HP:0005921)3.38681366
30Rectal prolapse (HP:0002035)3.26255107
31Increased serum ferritin (HP:0003281)3.20136727
32Slow saccadic eye movements (HP:0000514)3.02116814
33Abnormality of B cell number (HP:0010975)2.99780107
34Ectopic kidney (HP:0000086)2.99143818
35Short thumb (HP:0009778)2.95960875
36Meckel diverticulum (HP:0002245)2.87849646
37Hamartoma (HP:0010566)2.84552787
38Thyroiditis (HP:0100646)2.82099462
39Abnormality of the ileum (HP:0001549)2.79821036
40Progressive muscle weakness (HP:0003323)2.75400408
41Prominent nose (HP:0000448)2.74378644
42Gonadotropin excess (HP:0000837)2.62769078
43Skin tags (HP:0010609)2.62536478
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60799892
45Coronal craniosynostosis (HP:0004440)2.57377479
46Sloping forehead (HP:0000340)2.55665431
47Vertebral fusion (HP:0002948)2.46760623
48Anomalous pulmonary venous return (HP:0010772)2.43872411
49Clubbing of toes (HP:0100760)2.42513211
50Urethral obstruction (HP:0000796)2.41974067
51Abnormality of iron homeostasis (HP:0011031)2.40295491
52Tongue fasciculations (HP:0001308)2.39549458
53Abnormality of the carotid arteries (HP:0005344)2.38512600
54Rough bone trabeculation (HP:0100670)2.35140759
55Premature graying of hair (HP:0002216)2.31276623
56Small intestinal stenosis (HP:0012848)2.29669223
57Duodenal stenosis (HP:0100867)2.29669223
58Small hand (HP:0200055)2.26062254
59Nephroblastoma (Wilms tumor) (HP:0002667)2.25228418
60Bone marrow hypocellularity (HP:0005528)2.22403096
61Arteriovenous malformation (HP:0100026)2.17358222
62Abnormality of incisor morphology (HP:0011063)2.16447362
63Sprengel anomaly (HP:0000912)2.14595335
64Hypoplastic iliac wings (HP:0002866)2.13127745
65Malignant neoplasm of the central nervous system (HP:0100836)2.11002142
66Embryonal renal neoplasm (HP:0011794)2.10867351
67Abnormality of the pulmonary veins (HP:0011718)2.10572436
68Abnormality of the renal collecting system (HP:0004742)2.09530659
69Severe combined immunodeficiency (HP:0004430)2.05052859
70Severe visual impairment (HP:0001141)2.02827596
71Abnormality of the columella (HP:0009929)2.02622389
72Fibrous tissue neoplasm (HP:0012316)2.02442637
73Horseshoe kidney (HP:0000085)2.00688606
74Fibroma (HP:0010614)1.98697662
75Lymphangioma (HP:0100764)1.98513424
76Intestinal polyp (HP:0005266)1.98264082
77Muscle fibrillation (HP:0010546)1.97452936
78Myelodysplasia (HP:0002863)1.95284591
79Abnormality of transition element cation homeostasis (HP:0011030)1.95049981
80Panhypogammaglobulinemia (HP:0003139)1.91104530
81Combined immunodeficiency (HP:0005387)1.90532936
82Ovarian neoplasm (HP:0100615)1.89565743
83Squamous cell carcinoma (HP:0002860)1.86458522
84Aplastic anemia (HP:0001915)1.85006813
85Conical tooth (HP:0000698)1.82457942
86Cellular immunodeficiency (HP:0005374)1.82274110
87Abnormality of the duodenum (HP:0002246)1.82152868
88Pendular nystagmus (HP:0012043)1.79822778
89Abnormality of cochlea (HP:0000375)1.76776900
90Short ribs (HP:0000773)1.76268667
91Hypoplastic pelvis (HP:0008839)1.68368138
92Absent thumb (HP:0009777)1.67966419
93Oligodontia (HP:0000677)1.67958727
94Abnormal trabecular bone morphology (HP:0100671)1.64288323
95Sparse lateral eyebrow (HP:0005338)1.63816361
96Hypoplasia of the thymus (HP:0000778)1.62230903
97Decreased central vision (HP:0007663)1.61584510
98Eosinophilia (HP:0001880)1.60345546
99Prostate neoplasm (HP:0100787)1.59580127
100Abnormality of DNA repair (HP:0003254)1.57383498

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.57454618
2VRK15.20808199
3RPS6KA52.91456852
4STK42.29631784
5DAPK32.23345819
6ZAK10.0676292
7AURKA1.57316018
8PKN11.55565904
9NLK1.52578122
10CAMK41.49236334
11EIF2AK31.45046549
12MAP3K91.30065691
13MELK1.21798058
14AURKB1.21329065
15MAP3K81.18140933
16MST41.07065746
17PLK41.04159906
18PIM11.02565025
19MAP2K70.95651874
20BMPR1B0.86836326
21PINK10.84609632
22CHEK20.84401051
23CDC70.82357165
24BLK0.81543024
25NEK90.72783124
26STK38L0.70846179
27NEK10.70315104
28MAP3K20.67393955
29CDK70.64883558
30ACVR1B0.64354247
31SCYL20.63928196
32CAMKK20.59920020
33MAP3K30.59602939
34CCNB10.58973326
35PRKCQ0.56359318
36RPS6KA40.56252360
37MAPK70.56213988
38MAP3K70.55540748
39TTK0.55531885
40PRKAA10.54907243
41MARK30.51122860
42AKT30.50492433
43LATS10.50080986
44CDK80.49179077
45RIPK10.48873161
46BUB10.48392177
47BRSK10.48097472
48BTK0.47666586
49NEK20.46455621
50WEE10.45330991
51SGK20.45241318
52TAF10.43968291
53AKT20.43959702
54NME20.43618711
55STK30.41648112
56BRSK20.37751674
57CDK30.37660654
58PLK10.35739228
59NEK60.35345966
60JAK20.33688704
61MAP3K60.31967877
62PAK10.31773424
63MAP3K40.30649532
64GRK10.30450923
65BRD40.29408845
66SGK10.27199745
67ATR0.25941009
68SYK0.24593535
69ROCK10.24358101
70EIF2AK20.23318917
71SGK30.23195947
72HIPK20.22908627
73ATM0.22840526
74MAPK110.22612649
75CAMK10.22279035
76MAP3K100.21517355
77TEC0.20649799
78CSNK1A1L0.20250817
79CHEK10.20039153
80MAP3K120.18507604
81SGK2230.18457330
82SGK4940.18457330
83PBK0.17562898
84BRAF0.16822451
85CDK90.16598884
86PRKCH0.16285939
87OBSCN0.15535119
88ITK0.15467322
89IKBKB0.14676015
90INSRR0.14482266
91PAK20.14129855
92STK240.12772027
93MAP3K10.12400148
94RPS6KB10.11952981
95RPS6KA30.10514437
96HCK0.10408231
97STK380.10126904
98STK160.09200659
99CDK60.08504620
100CDK20.07260236

Predicted pathways (KEGG)

RankGene SetZ-score
1Alcoholism_Homo sapiens_hsa050348.72881123
2Viral carcinogenesis_Homo sapiens_hsa052034.07396144
3Transcriptional misregulation in cancer_Homo sapiens_hsa052022.06396667
4Systemic lupus erythematosus_Homo sapiens_hsa0532211.8201417
5Fanconi anemia pathway_Homo sapiens_hsa034601.53670963
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46223866
7Hedgehog signaling pathway_Homo sapiens_hsa043401.32900350
8DNA replication_Homo sapiens_hsa030301.21880619
9Basal cell carcinoma_Homo sapiens_hsa052171.19358682
10Cell cycle_Homo sapiens_hsa041101.07913063
11Melanoma_Homo sapiens_hsa052180.92999851
12Homologous recombination_Homo sapiens_hsa034400.89303755
13Basal transcription factors_Homo sapiens_hsa030220.85572589
14Ribosome_Homo sapiens_hsa030100.84908618
15Intestinal immune network for IgA production_Homo sapiens_hsa046720.80837193
16T cell receptor signaling pathway_Homo sapiens_hsa046600.74675488
17Mismatch repair_Homo sapiens_hsa034300.70477103
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70011686
19Nucleotide excision repair_Homo sapiens_hsa034200.69508530
20Primary immunodeficiency_Homo sapiens_hsa053400.68455224
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63936950
22NF-kappa B signaling pathway_Homo sapiens_hsa040640.63898572
23Non-small cell lung cancer_Homo sapiens_hsa052230.63873964
24Glioma_Homo sapiens_hsa052140.62639986
25Thyroid cancer_Homo sapiens_hsa052160.61102216
26B cell receptor signaling pathway_Homo sapiens_hsa046620.55769794
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53257799
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51435449
29MicroRNAs in cancer_Homo sapiens_hsa052060.51053059
30Oocyte meiosis_Homo sapiens_hsa041140.50779619
31HTLV-I infection_Homo sapiens_hsa051660.47877647
32p53 signaling pathway_Homo sapiens_hsa041150.47803608
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44491483
34RNA transport_Homo sapiens_hsa030130.43686133
35Prostate cancer_Homo sapiens_hsa052150.40210120
36One carbon pool by folate_Homo sapiens_hsa006700.40078892
37Measles_Homo sapiens_hsa051620.39615223
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39390120
39Dorso-ventral axis formation_Homo sapiens_hsa043200.37336298
40Acute myeloid leukemia_Homo sapiens_hsa052210.36465281
41Circadian rhythm_Homo sapiens_hsa047100.36088872
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36034191
43Chronic myeloid leukemia_Homo sapiens_hsa052200.35468917
44Endometrial cancer_Homo sapiens_hsa052130.33971957
45Small cell lung cancer_Homo sapiens_hsa052220.33430845
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32796948
47Pancreatic cancer_Homo sapiens_hsa052120.31684515
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30311784
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29657146
50Spliceosome_Homo sapiens_hsa030400.29638847
51TNF signaling pathway_Homo sapiens_hsa046680.28892246
52Pathways in cancer_Homo sapiens_hsa052000.28648619
53Herpes simplex infection_Homo sapiens_hsa051680.28589340
54Hepatitis B_Homo sapiens_hsa051610.26939747
55RNA degradation_Homo sapiens_hsa030180.25316794
56Colorectal cancer_Homo sapiens_hsa052100.24695319
57mRNA surveillance pathway_Homo sapiens_hsa030150.24255451
58Pyrimidine metabolism_Homo sapiens_hsa002400.23766823
59Purine metabolism_Homo sapiens_hsa002300.22910369
60Apoptosis_Homo sapiens_hsa042100.22782542
61Epstein-Barr virus infection_Homo sapiens_hsa051690.21065768
62ErbB signaling pathway_Homo sapiens_hsa040120.20544704
63FoxO signaling pathway_Homo sapiens_hsa040680.20361275
64Non-homologous end-joining_Homo sapiens_hsa034500.19598494
65Prolactin signaling pathway_Homo sapiens_hsa049170.19522493
66mTOR signaling pathway_Homo sapiens_hsa041500.19163663
67MAPK signaling pathway_Homo sapiens_hsa040100.18482205
68Wnt signaling pathway_Homo sapiens_hsa043100.18343295
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17447061
70Osteoclast differentiation_Homo sapiens_hsa043800.17233477
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16807629
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.16361508
73Base excision repair_Homo sapiens_hsa034100.16211402
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.14724151
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.12608871
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12454084
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12287127
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.12197921
79Long-term potentiation_Homo sapiens_hsa047200.11674819
80Melanogenesis_Homo sapiens_hsa049160.11158918
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10836039
82Hematopoietic cell lineage_Homo sapiens_hsa046400.09872484
83Gap junction_Homo sapiens_hsa045400.09763873
84Cholinergic synapse_Homo sapiens_hsa047250.09350098
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.08653428
86TGF-beta signaling pathway_Homo sapiens_hsa043500.08612136
87Influenza A_Homo sapiens_hsa051640.07904143
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07454051
89Inositol phosphate metabolism_Homo sapiens_hsa005620.06422140
90Ras signaling pathway_Homo sapiens_hsa040140.06230248
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.04633756
92Olfactory transduction_Homo sapiens_hsa047400.03472962
93Renal cell carcinoma_Homo sapiens_hsa052110.03158996
94Bladder cancer_Homo sapiens_hsa052190.02081344
95Hepatitis C_Homo sapiens_hsa051600.01859783
96Lysine degradation_Homo sapiens_hsa003100.01837569
97Hippo signaling pathway_Homo sapiens_hsa043900.01246202
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.00322728
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.00172605
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.00115440

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