ROBO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of oligodendrocyte differentiation (GO:0048715)7.07403672
2response to pheromone (GO:0019236)5.49659604
3cell-cell junction maintenance (GO:0045217)4.88784147
4proximal/distal pattern formation (GO:0009954)4.82301802
5presynaptic membrane assembly (GO:0097105)4.78386695
6negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.70728932
7negative regulation of translation, ncRNA-mediated (GO:0040033)4.70728932
8regulation of translation, ncRNA-mediated (GO:0045974)4.70728932
9pyrimidine nucleobase catabolic process (GO:0006208)4.68394619
10axonal fasciculation (GO:0007413)4.49256818
11cell junction maintenance (GO:0034331)4.40541755
12presynaptic membrane organization (GO:0097090)4.32159847
13* neuron recognition (GO:0008038)4.21689818
14hippocampus development (GO:0021766)4.09860321
15paraxial mesoderm development (GO:0048339)4.03629902
16layer formation in cerebral cortex (GO:0021819)3.91733231
17regulation of transcription involved in cell fate commitment (GO:0060850)3.91678999
18central nervous system projection neuron axonogenesis (GO:0021952)3.90665792
19lateral sprouting from an epithelium (GO:0060601)3.86525013
20negative regulation of Notch signaling pathway (GO:0045746)3.82994117
21dendritic spine morphogenesis (GO:0060997)3.77805830
22postsynaptic membrane organization (GO:0001941)3.77717055
23negative regulation of glial cell differentiation (GO:0045686)3.75263157
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.67155928
25olfactory bulb development (GO:0021772)3.65130142
26embryonic cranial skeleton morphogenesis (GO:0048701)3.59403034
27head development (GO:0060322)3.56278173
28regulation of oligodendrocyte differentiation (GO:0048713)3.55722269
29nucleobase catabolic process (GO:0046113)3.54459493
30G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.53348673
31establishment of planar polarity (GO:0001736)3.50577010
32establishment of tissue polarity (GO:0007164)3.50577010
33neurotransmitter-gated ion channel clustering (GO:0072578)3.44698175
34cell migration in hindbrain (GO:0021535)3.38073402
35regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.36966263
36vocalization behavior (GO:0071625)3.35317898
37establishment of nucleus localization (GO:0040023)3.32357824
38negative regulation of axon extension involved in axon guidance (GO:0048843)3.32177779
39planar cell polarity pathway involved in neural tube closure (GO:0090179)3.30434522
40dorsal/ventral axis specification (GO:0009950)3.28964084
41positive regulation of dendritic spine morphogenesis (GO:0061003)3.28156780
42polarized epithelial cell differentiation (GO:0030859)3.27957113
43calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.18901378
44nonmotile primary cilium assembly (GO:0035058)3.12367193
45negative regulation of gliogenesis (GO:0014014)3.12332685
46neuron cell-cell adhesion (GO:0007158)3.11930741
47limb bud formation (GO:0060174)3.08620284
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07154309
49negative regulation of catenin import into nucleus (GO:0035414)3.02928864
50cerebellar Purkinje cell differentiation (GO:0021702)3.02876094
51regulation of axon extension involved in axon guidance (GO:0048841)2.99131297
52negative regulation of axon guidance (GO:1902668)2.98947979
53embryonic retina morphogenesis in camera-type eye (GO:0060059)2.94960659
54positive regulation of gastrulation (GO:2000543)2.92466926
55peptidyl-arginine methylation (GO:0018216)2.92045894
56peptidyl-arginine N-methylation (GO:0035246)2.92045894
57peptidyl-arginine omega-N-methylation (GO:0035247)2.91698529
58dendrite morphogenesis (GO:0048813)2.90792843
59barbed-end actin filament capping (GO:0051016)2.90386300
60negative regulation of sodium ion transport (GO:0010766)2.89365775
61epithelial cell-cell adhesion (GO:0090136)2.88031134
62positive regulation of dendritic spine development (GO:0060999)2.87468902
63regulation of synapse structural plasticity (GO:0051823)2.86600670
64ganglion development (GO:0061548)2.86307256
65regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.85052112
66stress granule assembly (GO:0034063)2.84103659
67positive regulation of filopodium assembly (GO:0051491)2.82036393
68regulation of axon guidance (GO:1902667)2.81517483
69synapse assembly (GO:0007416)2.81299985
70establishment of mitochondrion localization (GO:0051654)2.79869713
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.79008488
72regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.78430288
73gastrulation with mouth forming second (GO:0001702)2.77227541
74central nervous system neuron axonogenesis (GO:0021955)2.74518031
75apical protein localization (GO:0045176)2.72757706
76neuron fate commitment (GO:0048663)2.71617968
77protein localization to synapse (GO:0035418)2.69480397
78regulation of long-term neuronal synaptic plasticity (GO:0048169)2.68179946
79neuron migration (GO:0001764)2.64302796
80ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.63697109
81cellular component maintenance (GO:0043954)2.63568811
82cellular response to electrical stimulus (GO:0071257)2.63505518
83axon extension (GO:0048675)2.60880915
84bone trabecula formation (GO:0060346)2.59994263
85spinal cord development (GO:0021510)2.59877216
86negative regulation of microtubule polymerization (GO:0031115)2.59189634
87ionotropic glutamate receptor signaling pathway (GO:0035235)2.59080474
88insulin-like growth factor receptor signaling pathway (GO:0048009)2.56881475
89forebrain neuron differentiation (GO:0021879)2.55605073
90convergent extension (GO:0060026)2.55201554
91synaptic vesicle maturation (GO:0016188)2.55126188
92* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.55043451
93substrate-independent telencephalic tangential migration (GO:0021826)2.51556742
94substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.51556742
95cerebral cortex neuron differentiation (GO:0021895)2.50000011
96membrane hyperpolarization (GO:0060081)2.49366903
97gamma-aminobutyric acid transport (GO:0015812)2.48977962
98auditory behavior (GO:0031223)2.48697270
99regulation of non-canonical Wnt signaling pathway (GO:2000050)2.47644466
100locomotory exploration behavior (GO:0035641)2.47490272
101retinal ganglion cell axon guidance (GO:0031290)2.47448522
102adherens junction organization (GO:0034332)2.47384794
103regulation of neuron migration (GO:2001222)2.47261764
104craniofacial suture morphogenesis (GO:0097094)2.46113742
105synaptic vesicle exocytosis (GO:0016079)2.43983281
106negative regulation of vascular permeability (GO:0043116)2.43097482
107cerebral cortex cell migration (GO:0021795)2.42786818
108RNA localization (GO:0006403)2.41966107
109cerebral cortex radially oriented cell migration (GO:0021799)2.41950242
110body morphogenesis (GO:0010171)2.40866628
111collecting duct development (GO:0072044)2.40694608
112cell proliferation in forebrain (GO:0021846)2.39947231
113regulation of neuronal synaptic plasticity (GO:0048168)2.39593462
114limb development (GO:0060173)2.39441847
115appendage development (GO:0048736)2.39441847
116regulation of glutamate receptor signaling pathway (GO:1900449)2.39164609
117neuron projection extension involved in neuron projection guidance (GO:1902284)2.38065378
118axon extension involved in axon guidance (GO:0048846)2.38065378
119regulation of establishment of planar polarity (GO:0090175)2.37960341
120axonogenesis (GO:0007409)2.36831683
121positive regulation of synapse assembly (GO:0051965)2.36375674
122positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.35372934
123pre-miRNA processing (GO:0031054)2.35215469
124dendritic spine organization (GO:0097061)2.34774926
125exploration behavior (GO:0035640)2.34748860
126midbrain development (GO:0030901)2.33989080
127positive regulation of dendrite morphogenesis (GO:0050775)2.31287406
128regulation of NFAT protein import into nucleus (GO:0051532)2.29967301
129morphogenesis of an epithelial sheet (GO:0002011)2.29485402
130ectodermal placode formation (GO:0060788)2.28598411
131synapse organization (GO:0050808)2.28350865
132dermatan sulfate biosynthetic process (GO:0030208)2.28063408
133regulation of synapse assembly (GO:0051963)2.27651146
134mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.27141798
135membrane assembly (GO:0071709)2.26596284
136lens morphogenesis in camera-type eye (GO:0002089)2.25528661
137embryonic foregut morphogenesis (GO:0048617)2.25472521
138asymmetric protein localization (GO:0008105)2.25014449
139neuronal stem cell maintenance (GO:0097150)2.24865741
140neuron projection extension (GO:1990138)2.23155800
141establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.18616991
142regulation of growth hormone secretion (GO:0060123)2.17621240
143post-anal tail morphogenesis (GO:0036342)2.16632656
144Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.14883796
145developmental cell growth (GO:0048588)2.14758984
146sympathetic nervous system development (GO:0048485)2.14675485
147cell surface receptor signaling pathway involved in heart development (GO:0061311)2.13079375
148regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.12913642
149cellular response to cholesterol (GO:0071397)2.11176213
150cranial nerve development (GO:0021545)2.10124867
151cochlea morphogenesis (GO:0090103)2.10056528
152cytoplasmic mRNA processing body assembly (GO:0033962)2.09083051
153negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.08570565
154ephrin receptor signaling pathway (GO:0048013)2.07837860
155negative regulation of cytosolic calcium ion concentration (GO:0051481)2.06933520
156negative regulation of dendrite development (GO:2000171)2.06326508
157response to auditory stimulus (GO:0010996)2.05460319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.17765719
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.73505462
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.08366088
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.86473360
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.85856492
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81953965
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71108578
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71108578
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.66911893
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56957670
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.54682791
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49232036
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45392378
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41005736
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35059940
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24201310
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.20515615
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.18795879
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.13967833
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09955931
21* GBX2_23144817_ChIP-Seq_PC3_Human2.07069338
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.98569449
23IGF1R_20145208_ChIP-Seq_DFB_Human1.98525745
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.97732791
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.96498860
26AR_21572438_ChIP-Seq_LNCaP_Human1.90300439
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88752874
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.87244223
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86545852
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.83354990
31RING1B_27294783_Chip-Seq_NPCs_Mouse1.80390919
32* TAF15_26573619_Chip-Seq_HEK293_Human1.78740848
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.76543847
34* FUS_26573619_Chip-Seq_HEK293_Human1.76279079
35* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74652372
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71327861
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.70229749
38* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68701476
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.67029365
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66029148
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.65885497
42RNF2_27304074_Chip-Seq_NSC_Mouse1.65709047
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.64855853
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59284561
45* REST_21632747_ChIP-Seq_MESCs_Mouse1.58448608
46* ISL1_27105846_Chip-Seq_CPCs_Mouse1.58014210
47TP53_20018659_ChIP-ChIP_R1E_Mouse1.57911676
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.57905972
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.57210682
50DROSHA_22980978_ChIP-Seq_HELA_Human1.56921296
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52689843
52* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44750967
53* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41686700
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41600480
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40829247
56* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39828524
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39570832
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.37539202
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37264689
60ZNF274_21170338_ChIP-Seq_K562_Hela1.36835835
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36826983
62RARB_27405468_Chip-Seq_BRAIN_Mouse1.35620902
63TBX3_20139965_ChIP-Seq_MESCs_Mouse1.35223122
64TBX3_20139965_ChIP-Seq_ESCs_Mouse1.34601464
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34272996
66OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33802483
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33353132
68* SOX9_26525672_Chip-Seq_HEART_Mouse1.33037767
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31943770
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31851715
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30928747
72* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28742250
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28403251
74P300_19829295_ChIP-Seq_ESCs_Human1.27883887
75* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27843130
76* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25691042
77TP53_18474530_ChIP-ChIP_U2OS_Human1.25647212
78* EWS_26573619_Chip-Seq_HEK293_Human1.21655123
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.21542631
80* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21499671
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.20945512
82TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.20832575
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20009167
84KDM2B_26808549_Chip-Seq_K562_Human1.19293464
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17614328
86POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.17535637
87* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17334072
88* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17126374
89* STAT3_23295773_ChIP-Seq_U87_Human1.13760870
90* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13374956
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10948763
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10295759
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10295759
94REST_18959480_ChIP-ChIP_MESCs_Mouse1.09575418
95* SMAD4_21799915_ChIP-Seq_A2780_Human1.08922079
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08721507
97* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08305922
98* ARNT_22903824_ChIP-Seq_MCF-7_Human1.07810849
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07011350
100* PIAS1_25552417_ChIP-Seq_VCAP_Human1.06920035
101NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06592978
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06592978
103* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06071390
104* AR_19668381_ChIP-Seq_PC3_Human1.03387620
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03085581
106* SMAD4_21741376_ChIP-Seq_HESCs_Human1.02547468
107SOX2_16153702_ChIP-ChIP_HESCs_Human1.02437355
108* AHR_22903824_ChIP-Seq_MCF-7_Human1.01975646
109SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01586675
110* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01453113
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.00052136
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99741960
113* SMAD3_21741376_ChIP-Seq_ESCs_Human0.99738585
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98667592
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98016365
116IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97870840
117* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95742747
118* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95612458
119* AR_25329375_ChIP-Seq_VCAP_Human0.95418245
120* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95220719
121* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93903476
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92433041
123* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91521367
124GATA1_26923725_Chip-Seq_HPCs_Mouse0.90780225
125TRIM28_21343339_ChIP-Seq_HEK293_Human0.88348416
126EP300_21415370_ChIP-Seq_HL-1_Mouse0.88176846
127KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86691319
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85714115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.37553666
2MP0003122_maternal_imprinting3.76254177
3MP0008789_abnormal_olfactory_epithelium3.35912563
4MP0005248_abnormal_Harderian_gland3.20517810
5MP0005394_taste/olfaction_phenotype2.95444551
6MP0005499_abnormal_olfactory_system2.95444551
7MP0000049_abnormal_middle_ear2.90181775
8MP0003880_abnormal_central_pattern2.88254530
9MP0001346_abnormal_lacrimal_gland2.81819254
10* MP0000778_abnormal_nervous_system2.73958922
11MP0000566_synostosis2.63883638
12MP0004859_abnormal_synaptic_plasticity2.42470479
13MP0001270_distended_abdomen2.14143555
14MP0003121_genomic_imprinting2.09183672
15MP0000537_abnormal_urethra_morphology2.07201819
16MP0002249_abnormal_larynx_morphology2.00801922
17MP0002822_catalepsy1.98545063
18MP0002653_abnormal_ependyma_morphology1.97436893
19MP0003385_abnormal_body_wall1.90639150
20MP0003755_abnormal_palate_morphology1.81409218
21MP0004858_abnormal_nervous_system1.78042255
22MP0009053_abnormal_anal_canal1.77807028
23MP0000534_abnormal_ureter_morphology1.73096771
24MP0005646_abnormal_pituitary_gland1.68972033
25MP0005645_abnormal_hypothalamus_physiol1.68197743
26MP0001188_hyperpigmentation1.66847582
27MP0005187_abnormal_penis_morphology1.65383215
28MP0008438_abnormal_cutaneous_collagen1.63210076
29MP0002184_abnormal_innervation1.63133689
30MP0003635_abnormal_synaptic_transmissio1.61042392
31MP0003942_abnormal_urinary_system1.60419163
32MP0001984_abnormal_olfaction1.58991173
33MP0003937_abnormal_limbs/digits/tail_de1.56868904
34MP0006276_abnormal_autonomic_nervous1.53340252
35MP0002233_abnormal_nose_morphology1.52765978
36MP0003890_abnormal_embryonic-extraembry1.52754187
37MP0003938_abnormal_ear_development1.52351046
38MP0002116_abnormal_craniofacial_bone1.50602005
39MP0003935_abnormal_craniofacial_develop1.49033210
40* MP0003861_abnormal_nervous_system1.48883599
41MP0009250_abnormal_appendicular_skeleto1.44928876
42MP0004270_analgesia1.43927368
43* MP0003115_abnormal_respiratory_system1.43220518
44* MP0000955_abnormal_spinal_cord1.42798323
45MP0002751_abnormal_autonomic_nervous1.38706306
46MP0003119_abnormal_digestive_system1.34721253
47MP0002063_abnormal_learning/memory/cond1.33702966
48MP0002557_abnormal_social/conspecific_i1.31804259
49MP0000569_abnormal_digit_pigmentation1.30948298
50MP0005503_abnormal_tendon_morphology1.27858731
51* MP0004811_abnormal_neuron_physiology1.27116551
52MP0003567_abnormal_fetal_cardiomyocyte1.26683815
53MP0001299_abnormal_eye_distance/1.25612042
54MP0009384_cardiac_valve_regurgitation1.23808069
55MP0002177_abnormal_outer_ear1.21481951
56MP0005171_absent_coat_pigmentation1.19962605
57MP0002938_white_spotting1.16340285
58MP0001849_ear_inflammation1.16098441
59MP0000762_abnormal_tongue_morphology1.14911880
60* MP0002152_abnormal_brain_morphology1.14118815
61MP0002277_abnormal_respiratory_mucosa1.13430437
62MP0002735_abnormal_chemical_nociception1.13328966
63MP0002098_abnormal_vibrissa_morphology1.12467106
64MP0005076_abnormal_cell_differentiation1.11474017
65MP0010368_abnormal_lymphatic_system1.11361818
66MP0000428_abnormal_craniofacial_morphol1.10656979
67MP0003136_yellow_coat_color1.09200579
68MP0001177_atelectasis1.08272000
69* MP0002882_abnormal_neuron_morphology1.08131579
70MP0000163_abnormal_cartilage_morphology1.07502446
71MP0002282_abnormal_trachea_morphology1.06431266
72MP0009745_abnormal_behavioral_response1.06226498
73MP0004133_heterotaxia1.04403266
74MP0002909_abnormal_adrenal_gland1.03657854
75MP0000432_abnormal_head_morphology1.03616733
76MP0003283_abnormal_digestive_organ1.03220479
77* MP0002081_perinatal_lethality1.02129030
78MP0005423_abnormal_somatic_nervous1.00742452
79MP0002084_abnormal_developmental_patter1.00072060
80MP0008995_early_reproductive_senescence0.98349816
81MP0002234_abnormal_pharynx_morphology0.97871230
82MP0003315_abnormal_perineum_morphology0.97654367
83MP0002932_abnormal_joint_morphology0.97282166
84MP0000516_abnormal_urinary_system0.95419219
85MP0005367_renal/urinary_system_phenotyp0.95419219
86MP0002697_abnormal_eye_size0.95009638
87MP0000631_abnormal_neuroendocrine_gland0.94018149
88MP0003123_paternal_imprinting0.93716187
89MP0002064_seizures0.93202764
90MP0002102_abnormal_ear_morphology0.92587970
91MP0002572_abnormal_emotion/affect_behav0.91581281
92MP0002638_abnormal_pupillary_reflex0.91184593
93MP0006292_abnormal_olfactory_placode0.88819892
94MP0000462_abnormal_digestive_system0.88564446
95MP0000026_abnormal_inner_ear0.88292996
96MP0009046_muscle_twitch0.87523361
97* MP0001943_abnormal_respiration0.86810186
98MP0005409_darkened_coat_color0.86710832
99MP0002092_abnormal_eye_morphology0.86695746
100MP0009672_abnormal_birth_weight0.86001088
101MP0001340_abnormal_eyelid_morphology0.85537373
102MP0001486_abnormal_startle_reflex0.84884277
103MP0002109_abnormal_limb_morphology0.84473788
104MP0001529_abnormal_vocalization0.83931404
105MP0005391_vision/eye_phenotype0.83626471
106MP0005623_abnormal_meninges_morphology0.83247690
107MP0009703_decreased_birth_body0.83218229
108MP0004885_abnormal_endolymph0.81836430
109MP0002752_abnormal_somatic_nervous0.80528625
110MP0009780_abnormal_chondrocyte_physiolo0.80029365
111MP0001293_anophthalmia0.79660083
112MP0002734_abnormal_mechanical_nocicepti0.79476719
113MP0000579_abnormal_nail_morphology0.78787696
114MP0005257_abnormal_intraocular_pressure0.78696143
115MP0005275_abnormal_skin_tensile0.77917628
116MP0004272_abnormal_basement_membrane0.77588124
117MP0001286_abnormal_eye_development0.76693952
118MP0004197_abnormal_fetal_growth/weight/0.75959630
119MP0005508_abnormal_skeleton_morphology0.74582856
120MP0003941_abnormal_skin_development0.74113444
121MP0003705_abnormal_hypodermis_morpholog0.74050676
122MP0002733_abnormal_thermal_nociception0.72965587
123MP0002111_abnormal_tail_morphology0.72024397

Predicted human phenotypes

RankGene SetZ-score
1Split foot (HP:0001839)4.25202488
2Trigonocephaly (HP:0000243)4.09123123
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.06975514
4Short 4th metacarpal (HP:0010044)4.06975514
5Abnormality of the 4th metacarpal (HP:0010012)3.18276417
6Shallow orbits (HP:0000586)3.01053876
7Turricephaly (HP:0000262)3.00550217
8Polyphagia (HP:0002591)3.00507993
9Amyotrophic lateral sclerosis (HP:0007354)2.98569251
10Increased number of teeth (HP:0011069)2.88036907
11Abnormality of the labia minora (HP:0012880)2.80917721
12Failure to thrive in infancy (HP:0001531)2.80780489
13Renal duplication (HP:0000075)2.80388187
14Midline defect of the nose (HP:0004122)2.78116237
15Hepatoblastoma (HP:0002884)2.74856828
16Vitreoretinal degeneration (HP:0000655)2.73757796
17Sleep apnea (HP:0010535)2.67028838
18Cortical dysplasia (HP:0002539)2.66790279
19Long clavicles (HP:0000890)2.65266462
20Neoplasm of the heart (HP:0100544)2.47055697
21Wrist flexion contracture (HP:0001239)2.45462592
22Neonatal short-limb short stature (HP:0008921)2.42461123
23Coronal craniosynostosis (HP:0004440)2.30748807
24Abnormality of the diencephalon (HP:0010662)2.27874986
25Cutaneous finger syndactyly (HP:0010554)2.22337745
26Abnormality of the parietal bone (HP:0002696)2.20954070
27Small hand (HP:0200055)2.19179166
28Focal seizures (HP:0007359)2.16129909
29Lymphangioma (HP:0100764)2.09916230
30Papillary thyroid carcinoma (HP:0002895)2.05908457
31Abnormality of the corticospinal tract (HP:0002492)2.05381919
32Cutaneous syndactyly (HP:0012725)2.03393559
33Aplasia/Hypoplasia of the sternum (HP:0006714)2.03202852
34Excessive salivation (HP:0003781)2.03079964
35Drooling (HP:0002307)2.03079964
36Myelomeningocele (HP:0002475)2.00102831
37Insidious onset (HP:0003587)2.00038092
38Termporal pattern (HP:0011008)2.00038092
39Absent eyebrow (HP:0002223)1.99955891
40Protrusio acetabuli (HP:0003179)1.99548720
41Labial hypoplasia (HP:0000066)1.99394366
42Sacral dimple (HP:0000960)1.98819824
43Renovascular hypertension (HP:0100817)1.98755977
44Bronchomalacia (HP:0002780)1.98738618
45Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.95156175
46Exotropia (HP:0000577)1.93994316
47Aplasia involving bones of the upper limbs (HP:0009823)1.92305837
48Aplasia of the phalanges of the hand (HP:0009802)1.92305837
49Aplasia involving bones of the extremities (HP:0009825)1.92305837
50Abnormality of dentin (HP:0010299)1.90183486
51Limb dystonia (HP:0002451)1.89750993
52Myokymia (HP:0002411)1.89235092
53High anterior hairline (HP:0009890)1.88932245
54Elfin facies (HP:0004428)1.88773674
55Abnormal eating behavior (HP:0100738)1.88369812
56Ankle clonus (HP:0011448)1.86404290
57Hyperacusis (HP:0010780)1.84494533
58Vertebral arch anomaly (HP:0008438)1.83508941
59Decreased lacrimation (HP:0000633)1.83501518
60Broad alveolar ridges (HP:0000187)1.83442087
61Hypomagnesemia (HP:0002917)1.83226420
62Overriding aorta (HP:0002623)1.82944534
63Morphological abnormality of the middle ear (HP:0008609)1.82462252
64Premature rupture of membranes (HP:0001788)1.82356878
65Micropenis (HP:0000054)1.81736946
66Intellectual disability, moderate (HP:0002342)1.80612334
67Broad metatarsal (HP:0001783)1.79609335
68Abnormality of the astrocytes (HP:0100707)1.79527024
69Astrocytoma (HP:0009592)1.79527024
70Bladder diverticulum (HP:0000015)1.79447895
71Impaired vibration sensation in the lower limbs (HP:0002166)1.78609817
72Omphalocele (HP:0001539)1.77654589
73Urinary bladder sphincter dysfunction (HP:0002839)1.76720355
74Intestinal atresia (HP:0011100)1.75632056
75Abnormality of the antihelix (HP:0009738)1.75572323
76Insomnia (HP:0100785)1.73969403
77Hypoplasia of the brainstem (HP:0002365)1.73879131
78Aplasia/Hypoplasia of the brainstem (HP:0007362)1.73879131
79Shawl scrotum (HP:0000049)1.73447443
80Focal motor seizures (HP:0011153)1.72475219
81Urinary urgency (HP:0000012)1.72209417
82Synostosis involving the elbow (HP:0003938)1.71863654
83Humeroradial synostosis (HP:0003041)1.71863654
84Broad palm (HP:0001169)1.70747822
85Abnormality of abdominal situs (HP:0011620)1.69551214
86Abdominal situs inversus (HP:0003363)1.69551214
87Absent hand (HP:0004050)1.69072479
88Aqueductal stenosis (HP:0002410)1.68100323
89Hypoplastic female external genitalia (HP:0012815)1.68085296
90Anophthalmia (HP:0000528)1.67760855
91Hypoplastic labia majora (HP:0000059)1.67151713
92Arterial tortuosity (HP:0005116)1.66618014
93Alacrima (HP:0000522)1.66451403
94Shoulder girdle muscle weakness (HP:0003547)1.66378562
95Amblyopia (HP:0000646)1.65420025
96Absent eyelashes (HP:0000561)1.64341962
97Precocious puberty (HP:0000826)1.63453282
98Pointed chin (HP:0000307)1.63410883
99Macroorchidism (HP:0000053)1.63122698
100Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.62613392
101Degeneration of the lateral corticospinal tracts (HP:0002314)1.62613392
102Open mouth (HP:0000194)1.62502023
103Aplasia/Hypoplasia of the clavicles (HP:0006710)1.62452207
104Microglossia (HP:0000171)1.61639236
105Broad toe (HP:0001837)1.61426680
106Vascular tortuosity (HP:0004948)1.60762049
107Anteriorly placed anus (HP:0001545)1.60350774
108Lissencephaly (HP:0001339)1.60292075
109Abnormality of the ischium (HP:0003174)1.59968207
110Abnormality of the nasolacrimal system (HP:0000614)1.59888756
111Action tremor (HP:0002345)1.59294461
112Wide anterior fontanel (HP:0000260)1.58531586
113Choanal stenosis (HP:0000452)1.58523428
114Atrophic scars (HP:0001075)1.58391374
115Bifid tongue (HP:0010297)1.58366842
116Preaxial foot polydactyly (HP:0001841)1.58262602
117Atrophy/Degeneration involving motor neurons (HP:0007373)1.58055814
118Flat cornea (HP:0007720)1.57844306
119Renal hypoplasia (HP:0000089)1.57768336
120Wide cranial sutures (HP:0010537)1.57635297
121Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.57634967
122Abnormality of the pubic bones (HP:0003172)1.56874257
123Asymmetry of the thorax (HP:0001555)1.56770681
124Delayed closure of the anterior fontanelle (HP:0001476)1.56496126
125Narrow nasal bridge (HP:0000446)1.56141540
126Soft skin (HP:0000977)1.55172500
127Absent speech (HP:0001344)1.54204494
128Glioma (HP:0009733)1.54048030
129Abnormality of the lower motor neuron (HP:0002366)1.53727893
130Arnold-Chiari malformation (HP:0002308)1.53577908
131Megalencephaly (HP:0001355)1.53155852
132Symptomatic seizures (HP:0011145)1.52658867
133Increased nuchal translucency (HP:0010880)1.52539764
134Telecanthus (HP:0000506)1.52524741
135Hypoventilation (HP:0002791)1.52522265
136Cupped ear (HP:0000378)1.51480768
137Hammertoe (HP:0001765)1.51159236
138Bowel diverticulosis (HP:0005222)1.49390688
139Abnormality of the aortic arch (HP:0012303)1.48595788
140Hyperventilation (HP:0002883)1.48444742
141Broad long bones (HP:0005622)1.48083961
142Heterotopia (HP:0002282)1.47663232
143Gastroesophageal reflux (HP:0002020)1.46533210
144Obsessive-compulsive behavior (HP:0000722)1.46384705
145Broad thumb (HP:0011304)1.45623013
146Scrotal hypoplasia (HP:0000046)1.43959620
147Skull defect (HP:0001362)1.43605303
148Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.42318187
149Hypsarrhythmia (HP:0002521)1.41991862
150Pulmonic stenosis (HP:0001642)1.40741917
151Broad ribs (HP:0000885)1.39832008
152Pachygyria (HP:0001302)1.39271836
153EEG with generalized epileptiform discharges (HP:0011198)1.38756329
154Hemivertebrae (HP:0002937)1.38030756
155Mild short stature (HP:0003502)1.36829094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.28411807
2MAP3K94.01199270
3ICK3.56389530
4EPHB22.45271981
5MINK12.43359293
6UHMK12.17431307
7MAP3K42.13813934
8WNK32.13570929
9FGFR22.12221854
10NTRK22.05336765
11ERBB31.93448388
12KSR11.92592323
13DYRK21.92162132
14LATS21.91195710
15NTRK31.89430502
16BCR1.77619152
17MAP3K121.72428369
18SIK31.65466620
19DDR21.63943638
20MAPK131.56172613
21EPHA41.55863289
22BRD41.48620565
23IRAK21.47684159
24PDGFRA1.42628438
25AKT31.39553430
26PAK61.28315375
27FER1.27261212
28TRIM281.26788043
29SIK21.25144003
30ERBB21.25081068
31SRPK11.23856695
32MAP2K41.21776650
33STK38L1.20368360
34LATS11.19588917
35PAK31.18721606
36PNCK1.18554683
37MKNK21.15665210
38CDK121.15462666
39TYRO31.14432098
40PKN21.12827882
41ROCK11.10657449
42FGFR11.08961414
43ACVR1B1.06309674
44TGFBR11.03250522
45MAP3K61.01614222
46CASK1.01390389
47PTK20.99381298
48FGFR40.98654259
49CAMK1D0.97834560
50SGK4940.95522621
51SGK2230.95522621
52CSNK1A1L0.94496049
53EEF2K0.94394820
54BMPR1B0.93703453
55MAP3K100.92931157
56TNIK0.90727958
57PRKCZ0.88421336
58MKNK10.87884058
59ROCK20.87196100
60PRKD30.86236851
61MAP3K130.85519554
62CDK50.83903001
63CSNK1G20.83383523
64CDK140.81596062
65MAP2K70.80844481
66SGK20.80690743
67NTRK10.79815166
68SGK10.78316401
69PLK20.77175485
70CSNK1G30.76661007
71EPHA30.74946466
72CAMK1G0.74482791
73MET0.72006947
74PRKCG0.71946631
75DYRK1B0.71058023
76RPS6KA40.69615363
77SGK30.68688696
78FGFR30.68467519
79PHKG10.67788387
80PHKG20.67788387
81CDK180.65747691
82DMPK0.64922892
83MTOR0.64055289
84CHEK20.63524145
85PLK30.63483189
86TSSK60.63297983
87ADRBK10.63246152
88ERBB40.61986527
89DYRK30.61919859
90CSNK1G10.60896708
91CDK30.60438079
92RET0.59638218
93IRAK10.58676564
94CDC70.57369864
95MAPK90.56882635
96DAPK20.54113693
97CDK150.53170259
98CSNK1D0.52995734
99MAPK100.52496547
100CSNK1E0.50444260
101SIK10.49956479
102PDGFRB0.49597823
103ATM0.48749738
104PRKAA10.48203231
105ARAF0.48095851
106PRKDC0.47758112
107GSK3B0.46870969
108YES10.45918137
109RPS6KA20.45733734
110MAPK80.45674921
111ERN10.45274180
112LIMK10.45166974
113PTK60.44721717
114DYRK1A0.44370205
115MAPK140.44246316
116INSRR0.43608079
117CDC42BPA0.42485232
118PRKCE0.41864693
119CDK11A0.41711625
120FYN0.40918446
121NEK20.40901847
122PAK20.40595396
123RIPK10.40443636
124RPS6KA30.39784190
125MAP2K10.39595758
126FLT30.39025193
127MAP4K20.38407242
128CAMK2B0.38281158
129CDK10.38104336
130RPS6KB10.37528235
131CAMK2A0.35340891
132PKN10.33795126

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.76629576
2* Axon guidance_Homo sapiens_hsa043602.63040411
3Nicotine addiction_Homo sapiens_hsa050332.13010597
4Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.10879200
5Hedgehog signaling pathway_Homo sapiens_hsa043402.05511053
6Hippo signaling pathway_Homo sapiens_hsa043902.00404001
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.98307365
8Steroid biosynthesis_Homo sapiens_hsa001001.91310061
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84460559
10Wnt signaling pathway_Homo sapiens_hsa043101.81475692
11Gap junction_Homo sapiens_hsa045401.80100216
12Glutamatergic synapse_Homo sapiens_hsa047241.77341389
13Cocaine addiction_Homo sapiens_hsa050301.77089352
14GABAergic synapse_Homo sapiens_hsa047271.76087831
15Dopaminergic synapse_Homo sapiens_hsa047281.73199362
16Circadian entrainment_Homo sapiens_hsa047131.69452059
17Melanogenesis_Homo sapiens_hsa049161.69069597
18Insulin secretion_Homo sapiens_hsa049111.66569995
19Synaptic vesicle cycle_Homo sapiens_hsa047211.61783859
20Amphetamine addiction_Homo sapiens_hsa050311.54914899
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54500620
22Long-term potentiation_Homo sapiens_hsa047201.51851711
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50362782
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49641959
25Colorectal cancer_Homo sapiens_hsa052101.46413687
26Morphine addiction_Homo sapiens_hsa050321.43298752
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42431099
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39984323
29Cholinergic synapse_Homo sapiens_hsa047251.39346620
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38338248
31Type II diabetes mellitus_Homo sapiens_hsa049301.38165366
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38102646
33Olfactory transduction_Homo sapiens_hsa047401.38012334
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34127531
35Adherens junction_Homo sapiens_hsa045201.33664267
36Endometrial cancer_Homo sapiens_hsa052131.30817744
37Dorso-ventral axis formation_Homo sapiens_hsa043201.29608698
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29144891
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28302692
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24517897
41Gastric acid secretion_Homo sapiens_hsa049711.23815553
42MicroRNAs in cancer_Homo sapiens_hsa052061.23028739
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18853309
44Estrogen signaling pathway_Homo sapiens_hsa049151.18418900
45Taste transduction_Homo sapiens_hsa047421.16254757
46Renin secretion_Homo sapiens_hsa049241.15850522
47ErbB signaling pathway_Homo sapiens_hsa040121.13163227
48Notch signaling pathway_Homo sapiens_hsa043301.11243092
49Long-term depression_Homo sapiens_hsa047301.10981854
50Oxytocin signaling pathway_Homo sapiens_hsa049211.09919013
51GnRH signaling pathway_Homo sapiens_hsa049121.08456965
52Glioma_Homo sapiens_hsa052141.07674043
53Serotonergic synapse_Homo sapiens_hsa047261.07571909
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06107064
55Proteoglycans in cancer_Homo sapiens_hsa052051.05351659
56Lysine degradation_Homo sapiens_hsa003101.05188221
57TGF-beta signaling pathway_Homo sapiens_hsa043501.04909063
58Dilated cardiomyopathy_Homo sapiens_hsa054141.04619081
59Salivary secretion_Homo sapiens_hsa049701.04085052
60Oocyte meiosis_Homo sapiens_hsa041141.03488016
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99977079
62Protein digestion and absorption_Homo sapiens_hsa049740.95340735
63Tight junction_Homo sapiens_hsa045300.91970618
64Focal adhesion_Homo sapiens_hsa045100.90465250
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89606330
66mTOR signaling pathway_Homo sapiens_hsa041500.87287027
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.84588638
68cAMP signaling pathway_Homo sapiens_hsa040240.84504329
69Calcium signaling pathway_Homo sapiens_hsa040200.84035024
70Butanoate metabolism_Homo sapiens_hsa006500.82614546
71Fatty acid metabolism_Homo sapiens_hsa012120.82554802
72ECM-receptor interaction_Homo sapiens_hsa045120.82413578
73Rap1 signaling pathway_Homo sapiens_hsa040150.81892967
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81592577
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81479423
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81031412
77Alcoholism_Homo sapiens_hsa050340.80288054
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.80162987
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77068106
80Fatty acid biosynthesis_Homo sapiens_hsa000610.76777862
81Ovarian steroidogenesis_Homo sapiens_hsa049130.75717070
82Pathways in cancer_Homo sapiens_hsa052000.75613553
83MAPK signaling pathway_Homo sapiens_hsa040100.74943644
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74801319
85Choline metabolism in cancer_Homo sapiens_hsa052310.73550855
86Thyroid hormone synthesis_Homo sapiens_hsa049180.73184431
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73117980
88Melanoma_Homo sapiens_hsa052180.71548247
89mRNA surveillance pathway_Homo sapiens_hsa030150.70743212
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69733849
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.68726631
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68526913
93Circadian rhythm_Homo sapiens_hsa047100.68258558
94Renal cell carcinoma_Homo sapiens_hsa052110.68014235
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67952039
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66297011
97Insulin signaling pathway_Homo sapiens_hsa049100.65903094
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65088150
99Ras signaling pathway_Homo sapiens_hsa040140.63099306
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61826353
101Prostate cancer_Homo sapiens_hsa052150.61396457
102AMPK signaling pathway_Homo sapiens_hsa041520.59328931
103Non-homologous end-joining_Homo sapiens_hsa034500.58616031
104Chronic myeloid leukemia_Homo sapiens_hsa052200.58471883
105Propanoate metabolism_Homo sapiens_hsa006400.58362702
106Glucagon signaling pathway_Homo sapiens_hsa049220.57548920
107Complement and coagulation cascades_Homo sapiens_hsa046100.57238411
108VEGF signaling pathway_Homo sapiens_hsa043700.57060897
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57033184
110HTLV-I infection_Homo sapiens_hsa051660.56123732
111Selenocompound metabolism_Homo sapiens_hsa004500.53516651
112Prion diseases_Homo sapiens_hsa050200.52795583
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52691168
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51828415
115Vibrio cholerae infection_Homo sapiens_hsa051100.50934325
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50868308
117Biosynthesis of amino acids_Homo sapiens_hsa012300.50091927
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.49173250
119Viral myocarditis_Homo sapiens_hsa054160.47846079
120RNA transport_Homo sapiens_hsa030130.46881886
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44181938
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.43993375

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