ROBO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1substrate-independent telencephalic tangential migration (GO:0021826)8.07884057
2substrate-independent telencephalic tangential interneuron migration (GO:0021843)8.07884057
3cerebellar Purkinje cell differentiation (GO:0021702)7.33148006
4negative regulation of neurotransmitter secretion (GO:0046929)5.99562269
5axonal fasciculation (GO:0007413)5.86885512
6dendritic spine morphogenesis (GO:0060997)5.79276264
7layer formation in cerebral cortex (GO:0021819)5.76145537
8pattern specification involved in kidney development (GO:0061004)5.70281807
9cell migration in hindbrain (GO:0021535)5.62810728
10metanephric mesenchyme development (GO:0072075)5.51901116
11axon ensheathment in central nervous system (GO:0032291)5.44614808
12central nervous system myelination (GO:0022010)5.44614808
13cell differentiation involved in metanephros development (GO:0072202)5.41290680
14neuron cell-cell adhesion (GO:0007158)5.28597292
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.22670112
16* neuron recognition (GO:0008038)5.20194701
17positive regulation of glomerulus development (GO:0090193)5.18426732
18behavioral response to nicotine (GO:0035095)5.16704915
19cranial nerve structural organization (GO:0021604)5.09928094
20regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.94822990
21vocalization behavior (GO:0071625)4.93172947
22mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.92570254
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.91120708
24body morphogenesis (GO:0010171)4.86146517
25embryonic body morphogenesis (GO:0010172)4.85784874
26regulation of short-term neuronal synaptic plasticity (GO:0048172)4.83602946
27cranial nerve morphogenesis (GO:0021602)4.83428523
28G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.79931408
29kidney mesenchyme development (GO:0072074)4.78891108
30mesenchymal cell differentiation involved in renal system development (GO:2001012)4.69519614
31mesenchymal cell differentiation involved in kidney development (GO:0072161)4.69519614
32tachykinin receptor signaling pathway (GO:0007217)4.66712737
33positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.65021132
34regulation of glutamate receptor signaling pathway (GO:1900449)4.63175772
35brain morphogenesis (GO:0048854)4.59798309
36positive regulation of protein homooligomerization (GO:0032464)4.59020129
37synaptic vesicle docking involved in exocytosis (GO:0016081)4.56727774
38synaptic vesicle maturation (GO:0016188)4.53107086
39cell differentiation in hindbrain (GO:0021533)4.52516127
40glial cell proliferation (GO:0014009)4.47572172
41regulation of nephron tubule epithelial cell differentiation (GO:0072182)4.44585397
42negative regulation of metanephros development (GO:0072217)4.43801272
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.42405041
44establishment of mitochondrion localization (GO:0051654)4.34429046
45regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.30027766
46collecting duct development (GO:0072044)4.27970845
47anatomical structure arrangement (GO:0048532)4.26742312
48synaptic transmission, dopaminergic (GO:0001963)4.23885859
49dendrite morphogenesis (GO:0048813)4.21036755
50mesonephros development (GO:0001823)4.18605459
51pyrimidine nucleobase catabolic process (GO:0006208)4.17947195
52response to pheromone (GO:0019236)4.15761673
53central nervous system projection neuron axonogenesis (GO:0021952)4.13124987
54spinal cord association neuron differentiation (GO:0021527)4.12109324
55locomotory exploration behavior (GO:0035641)4.11994403
56bone trabecula formation (GO:0060346)4.11401313
57regulation of dendritic spine morphogenesis (GO:0061001)4.11024326
58mating behavior (GO:0007617)4.05780455
59regulation of epithelial cell differentiation involved in kidney development (GO:2000696)4.05264879
60protein localization to synapse (GO:0035418)4.04213443
61mitochondrion transport along microtubule (GO:0047497)4.03114536
62establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.03114536
63nephron tubule formation (GO:0072079)4.02644989
64glutamate receptor signaling pathway (GO:0007215)3.99725470
65positive regulation of growth hormone secretion (GO:0060124)3.95491855
66embryonic retina morphogenesis in camera-type eye (GO:0060059)3.93243401
67positive regulation of gastrulation (GO:2000543)3.91366589
68negative regulation of neurotransmitter transport (GO:0051589)3.90816064
69positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.89477252
70regulation of neuron migration (GO:2001222)3.88433908
71uterus development (GO:0060065)3.85028697
72regulation of neuronal synaptic plasticity (GO:0048168)3.83971382
73glutamate secretion (GO:0014047)3.79337285
74positive regulation of mesonephros development (GO:0061213)3.68901202
75cornea development in camera-type eye (GO:0061303)3.68715875
76positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.68157703
77synaptic vesicle exocytosis (GO:0016079)3.65032965
78response to muscle activity (GO:0014850)3.64753739
79glucocorticoid biosynthetic process (GO:0006704)3.63665625
80specification of organ identity (GO:0010092)3.63128815
81dendritic spine organization (GO:0097061)3.61074691
82synaptic transmission, glutamatergic (GO:0035249)3.53935121
83cranial nerve development (GO:0021545)3.52873040
84regulation of apoptotic process involved in morphogenesis (GO:1902337)3.52650147
85neuronal action potential propagation (GO:0019227)3.48608844
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.46881618
87limb bud formation (GO:0060174)3.46470883
88regulation of synapse structural plasticity (GO:0051823)3.44778004
89regulation of dendritic spine development (GO:0060998)3.44492518
90metanephric nephron tubule development (GO:0072234)3.44080424
91metanephric tubule development (GO:0072170)3.44080424
92neuronal ion channel clustering (GO:0045161)3.43055714
93regulation of long-term neuronal synaptic plasticity (GO:0048169)3.42960311
94regulation of dendrite morphogenesis (GO:0048814)3.39964616
95cerebellum development (GO:0021549)3.39946088
96urogenital system development (GO:0001655)3.39321923
97ephrin receptor signaling pathway (GO:0048013)3.39122787
98parturition (GO:0007567)3.38081438
99positive regulation of membrane potential (GO:0045838)3.37020744
100positive regulation of metanephros development (GO:0072216)3.35376446
101nucleobase catabolic process (GO:0046113)3.34919908
102regulation of glomerulus development (GO:0090192)3.30713556
103cerebral cortex radially oriented cell migration (GO:0021799)3.30558719
104negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.30534145
105response to acidic pH (GO:0010447)3.28367816
106positive regulation of dendritic spine development (GO:0060999)3.27034087
107regulation of synaptic vesicle exocytosis (GO:2000300)3.26730631
108suckling behavior (GO:0001967)3.23699434
109transmission of nerve impulse (GO:0019226)3.21769496
110regulation of dendrite development (GO:0050773)3.21540511
111negative regulation of reactive oxygen species metabolic process (GO:2000378)3.21017480
112regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20427306
113cellular response to pH (GO:0071467)3.20390239
114presynaptic membrane organization (GO:0097090)3.19671920
115positive regulation of synapse assembly (GO:0051965)3.18953190
116peptidyl-tyrosine autophosphorylation (GO:0038083)3.18633555
117viral protein processing (GO:0019082)3.18498287
118negative regulation of catecholamine secretion (GO:0033604)3.17245366
119regulation of growth hormone secretion (GO:0060123)3.15632994
120regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.15408361
121phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.15009878
122positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.14220529
123neurotransmitter secretion (GO:0007269)3.14087219
124head development (GO:0060322)3.13777824
125positive regulation of dendritic spine morphogenesis (GO:0061003)3.12357435
126central nervous system neuron axonogenesis (GO:0021955)3.08976149
127postsynaptic membrane organization (GO:0001941)3.08601372
128neuromuscular process controlling balance (GO:0050885)3.07695704
129auditory behavior (GO:0031223)3.07344088
130regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07218971
131regulation of mesonephros development (GO:0061217)3.07012746
132regulation of postsynaptic membrane potential (GO:0060078)3.05158841
133regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.04663846
134cartilage condensation (GO:0001502)3.04126746
135cell aggregation (GO:0098743)3.04126746
136negative regulation of axon extension (GO:0030517)3.02969334
137mesenchymal to epithelial transition (GO:0060231)3.02899553
138gastrulation with mouth forming second (GO:0001702)3.01603623
139hippocampus development (GO:0021766)3.01059947
140nucleosome disassembly (GO:0006337)2.99569186
141protein-DNA complex disassembly (GO:0032986)2.99569186
142metanephric nephron epithelium development (GO:0072243)2.99461084
143negative regulation of axonogenesis (GO:0050771)2.98951805
144forebrain neuron differentiation (GO:0021879)2.98577409
145exploration behavior (GO:0035640)2.98546423
146regulation of cilium movement (GO:0003352)2.98203446
147neuron-neuron synaptic transmission (GO:0007270)2.96924460
148retinal ganglion cell axon guidance (GO:0031290)2.96726713
149positive regulation of synapse maturation (GO:0090129)2.95408242
150primitive streak formation (GO:0090009)2.94477243
151retina layer formation (GO:0010842)2.93485968
152regulation of respiratory system process (GO:0044065)2.92427335
153adult walking behavior (GO:0007628)2.91398295
154positive regulation of T cell apoptotic process (GO:0070234)2.89900005
155regulation of synaptic vesicle transport (GO:1902803)2.86939801
156axon extension (GO:0048675)2.86307838
157gamma-aminobutyric acid transport (GO:0015812)2.82510150
158spinal cord development (GO:0021510)2.79912384
159regulation of synaptic plasticity (GO:0048167)2.76901966
160regulation of synapse organization (GO:0050807)2.76870994
161regulation of synapse assembly (GO:0051963)2.76641234
162negative regulation of catenin import into nucleus (GO:0035414)2.76419492
163* neuron migration (GO:0001764)2.75635355
164neurofilament cytoskeleton organization (GO:0060052)2.73467835
165positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.72177631
166neuron projection morphogenesis (GO:0048812)2.70332864
167presynaptic membrane assembly (GO:0097105)2.69859468
168membrane hyperpolarization (GO:0060081)2.66933857
169central nervous system neuron differentiation (GO:0021953)2.66720122
170membrane depolarization (GO:0051899)2.66166176
171establishment of nucleus localization (GO:0040023)2.65220101
172cytoskeletal anchoring at plasma membrane (GO:0007016)2.64951793

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.93648706
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.04316411
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.12055348
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11189003
5GBX2_23144817_ChIP-Seq_PC3_Human3.05812155
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98471426
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.98218147
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89748085
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.84718935
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.84718935
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.80633936
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76253789
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53112087
14* EZH2_27294783_Chip-Seq_ESCs_Mouse2.52643416
15* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.50300241
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49477800
17* RNF2_27304074_Chip-Seq_ESCs_Mouse2.48209445
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.41290945
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40674355
20REST_21632747_ChIP-Seq_MESCs_Mouse2.35572222
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25004609
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23628546
23DROSHA_22980978_ChIP-Seq_HELA_Human2.18960951
24ERG_21242973_ChIP-ChIP_JURKAT_Human2.05140251
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01344924
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.96290531
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95575641
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94971059
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.94561802
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.89780536
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.85700255
32* RING1B_27294783_Chip-Seq_ESCs_Mouse1.84077250
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82722724
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81641391
35RING1B_27294783_Chip-Seq_NPCs_Mouse1.78289201
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.75716668
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.72615364
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71340438
39CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.70236210
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64887095
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64613749
42ZNF274_21170338_ChIP-Seq_K562_Hela1.60975133
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60022528
44* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.58175268
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55053837
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53726851
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50177343
48* RNF2_27304074_Chip-Seq_NSC_Mouse1.46574796
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44723848
50* KDM2B_26808549_Chip-Seq_K562_Human1.44187218
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.40618851
52IRF1_19129219_ChIP-ChIP_H3396_Human1.39882309
53TAF15_26573619_Chip-Seq_HEK293_Human1.36535846
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33918820
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33510611
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23471264
57SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23077225
58AR_21572438_ChIP-Seq_LNCaP_Human1.21924831
59NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.18107647
60* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17450987
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16288773
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16288773
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.15453598
64* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14966991
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13954633
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13022319
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11774763
68P300_19829295_ChIP-Seq_ESCs_Human1.11361908
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09155818
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08926487
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08474861
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07512309
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07025030
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05639984
75SMAD4_21799915_ChIP-Seq_A2780_Human1.05246542
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.04846486
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04717171
78CTCF_27219007_Chip-Seq_Bcells_Human1.04433839
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04051980
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03866215
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03710496
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02992756
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02729173
84* LXR_22292898_ChIP-Seq_THP-1_Human1.02698708
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00832249
86AR_19668381_ChIP-Seq_PC3_Human0.99725953
87ISL1_27105846_Chip-Seq_CPCs_Mouse0.98725041
88WT1_19549856_ChIP-ChIP_CCG9911_Human0.97890538
89YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96533778
90AHR_22903824_ChIP-Seq_MCF-7_Human0.96191433
91* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96072670
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95977179
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95397105
94SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95277165
95IGF1R_20145208_ChIP-Seq_DFB_Human0.95093715
96AR_25329375_ChIP-Seq_VCAP_Human0.95033831
97KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95016242
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94571464
99* SMAD3_21741376_ChIP-Seq_ESCs_Human0.94190912
100* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93855061
101MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.93635872
102ARNT_22903824_ChIP-Seq_MCF-7_Human0.93370648
103CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92909987
104P68_20966046_ChIP-Seq_HELA_Human0.92144706
105OCT4_19829295_ChIP-Seq_ESCs_Human0.91682546
106YY1_22570637_ChIP-Seq_MALME-3M_Human0.91632406
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90338062
108ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90115673
109MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.88799640
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88496804
111ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87853739
112TET1_21451524_ChIP-Seq_MESCs_Mouse0.87747305
113RXR_22108803_ChIP-Seq_LS180_Human0.87565323
114SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86794329
115SA1_27219007_Chip-Seq_ERYTHROID_Human0.86558901
116CREB1_26743006_Chip-Seq_LNCaP_Human0.86461102
117* KDM2B_26808549_Chip-Seq_JURKAT_Human0.85397643
118* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85238450
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.84256914
120E2F1_20622854_ChIP-Seq_HELA_Human0.83220802
121SA1_27219007_Chip-Seq_Bcells_Human0.83203583
122RUNX2_22187159_ChIP-Seq_PCA_Human0.82430106
123PHF8_20622854_ChIP-Seq_HELA_Human0.81941619
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81821878
125SOX3_22085726_ChIP-Seq_NPCs_Mouse0.81528905
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81520614
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.80827380
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80275472
129PIAS1_25552417_ChIP-Seq_VCAP_Human0.79495003
130EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79021075
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78791867
132HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.78707470
133* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.75932092
134REST_19997604_ChIP-ChIP_NEURONS_Mouse0.75746715
135* ELF1_20517297_ChIP-Seq_JURKAT_Human0.75432057
136MYC_27129775_Chip-Seq_CORNEA_Mouse0.74280858
137TP53_22127205_ChIP-Seq_IMR90_Human0.72592655
138KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.72548749
139STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.72508539
140RUNX1_26923725_Chip-Seq_HPCs_Mouse0.70017180
141PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.69961800
142KLF4_19829295_ChIP-Seq_ESCs_Human0.69596743

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.95873353
2* MP0003880_abnormal_central_pattern5.47797534
3MP0004270_analgesia4.03635023
4MP0005423_abnormal_somatic_nervous3.56054802
5MP0003635_abnormal_synaptic_transmissio3.44815089
6* MP0000778_abnormal_nervous_system3.38801352
7MP0001188_hyperpigmentation3.19342254
8MP0003123_paternal_imprinting3.16408672
9* MP0006276_abnormal_autonomic_nervous3.05056382
10MP0002063_abnormal_learning/memory/cond2.95879281
11MP0002653_abnormal_ependyma_morphology2.73309715
12MP0002734_abnormal_mechanical_nocicepti2.66262039
13MP0009745_abnormal_behavioral_response2.54954333
14MP0001486_abnormal_startle_reflex2.46993027
15MP0002064_seizures2.40472302
16MP0005623_abnormal_meninges_morphology2.27107501
17MP0002572_abnormal_emotion/affect_behav2.25926949
18MP0001485_abnormal_pinna_reflex2.12802642
19MP0004134_abnormal_chest_morphology2.06868431
20MP0004885_abnormal_endolymph1.96493303
21MP0002184_abnormal_innervation1.95597883
22MP0001968_abnormal_touch/_nociception1.91089825
23MP0002272_abnormal_nervous_system1.89204673
24MP0005257_abnormal_intraocular_pressure1.81231640
25MP0003315_abnormal_perineum_morphology1.78413339
26MP0002733_abnormal_thermal_nociception1.78399169
27MP0002163_abnormal_gland_morphology1.75613202
28MP0001970_abnormal_pain_threshold1.73625550
29MP0004145_abnormal_muscle_electrophysio1.73582572
30* MP0000955_abnormal_spinal_cord1.72593275
31MP0005187_abnormal_penis_morphology1.71217601
32MP0004811_abnormal_neuron_physiology1.67633747
33* MP0002882_abnormal_neuron_morphology1.63418454
34MP0002557_abnormal_social/conspecific_i1.62480610
35MP0003890_abnormal_embryonic-extraembry1.61992091
36MP0002909_abnormal_adrenal_gland1.60875760
37MP0001440_abnormal_grooming_behavior1.59901964
38MP0000537_abnormal_urethra_morphology1.55761006
39MP0009379_abnormal_foot_pigmentation1.55663078
40MP0003122_maternal_imprinting1.55349227
41MP0001501_abnormal_sleep_pattern1.54998026
42MP0009046_muscle_twitch1.53799496
43MP0003137_abnormal_impulse_conducting1.50781394
44* MP0002152_abnormal_brain_morphology1.46455239
45MP0002067_abnormal_sensory_capabilities1.45448785
46* MP0003861_abnormal_nervous_system1.44557925
47MP0004742_abnormal_vestibular_system1.44460473
48MP0002160_abnormal_reproductive_system1.43193840
49MP0003938_abnormal_ear_development1.42958953
50MP0005394_taste/olfaction_phenotype1.39009424
51MP0005499_abnormal_olfactory_system1.39009424
52MP0000569_abnormal_digit_pigmentation1.38723984
53MP0004133_heterotaxia1.38675343
54MP0002066_abnormal_motor_capabilities/c1.36804673
55MP0004858_abnormal_nervous_system1.35328654
56MP0002876_abnormal_thyroid_physiology1.31909452
57MP0003385_abnormal_body_wall1.31727370
58MP0003787_abnormal_imprinting1.31052960
59MP0004130_abnormal_muscle_cell1.30826243
60MP0003119_abnormal_digestive_system1.25919910
61MP0002736_abnormal_nociception_after1.23347219
62MP0002735_abnormal_chemical_nociception1.21956875
63MP0000631_abnormal_neuroendocrine_gland1.21463412
64MP0001905_abnormal_dopamine_level1.20694242
65MP0002822_catalepsy1.20104084
66MP0005645_abnormal_hypothalamus_physiol1.19026574
67MP0008569_lethality_at_weaning1.18067806
68MP0008789_abnormal_olfactory_epithelium1.17852055
69MP0004085_abnormal_heartbeat1.11665024
70MP0003879_abnormal_hair_cell1.09416941
71MP0001986_abnormal_taste_sensitivity1.08246008
72MP0005409_darkened_coat_color1.08018372
73MP0001286_abnormal_eye_development1.06332991
74MP0002069_abnormal_eating/drinking_beha1.05743847
75MP0000538_abnormal_urinary_bladder1.05604049
76MP0008961_abnormal_basal_metabolism1.05275526
77MP0000462_abnormal_digestive_system1.03695504
78MP0001293_anophthalmia1.03499555
79MP0008995_early_reproductive_senescence1.02074242
80MP0009780_abnormal_chondrocyte_physiolo1.01902483
81MP0005386_behavior/neurological_phenoty1.00471397
82MP0004924_abnormal_behavior1.00471397
83MP0010386_abnormal_urinary_bladder0.97397087
84MP0003011_delayed_dark_adaptation0.94799472
85MP0000026_abnormal_inner_ear0.94534151
86MP0002752_abnormal_somatic_nervous0.94209060
87* MP0002081_perinatal_lethality0.93968271
88MP0000534_abnormal_ureter_morphology0.93777107
89MP0002102_abnormal_ear_morphology0.92019262
90MP0000049_abnormal_middle_ear0.91624464
91MP0002751_abnormal_autonomic_nervous0.90112025
92MP0004142_abnormal_muscle_tone0.87028179
93MP0001502_abnormal_circadian_rhythm0.86492748
94MP0005195_abnormal_posterior_eye0.84753628
95MP0003329_amyloid_beta_deposits0.83992439
96MP0003121_genomic_imprinting0.83161354
97MP0000751_myopathy0.83043043
98MP0001963_abnormal_hearing_physiology0.82619856
99MP0001324_abnormal_eye_pigmentation0.82554330
100MP0003959_abnormal_lean_body0.81322999
101MP0000604_amyloidosis0.80097187
102MP0004233_abnormal_muscle_weight0.79974684
103MP0003283_abnormal_digestive_organ0.79961515
104MP0002932_abnormal_joint_morphology0.78210986
105MP0002638_abnormal_pupillary_reflex0.77597082
106MP0003633_abnormal_nervous_system0.77472152
107MP0005646_abnormal_pituitary_gland0.76170906
108MP0010030_abnormal_orbit_morphology0.76045029
109MP0001664_abnormal_digestion0.75671052
110MP0002229_neurodegeneration0.75623602
111MP0005389_reproductive_system_phenotype0.75588697
112* MP0003948_abnormal_gas_homeostasis0.75011661
113MP0002082_postnatal_lethality0.74772218
114MP0010770_preweaning_lethality0.74772218
115MP0006292_abnormal_olfactory_placode0.74745330
116MP0010769_abnormal_survival0.71457374
117* MP0001943_abnormal_respiration0.70147984
118MP0003631_nervous_system_phenotype0.69084777
119MP0010768_mortality/aging0.68520599
120MP0001529_abnormal_vocalization0.68475977
121MP0001984_abnormal_olfaction0.68017469
122MP0002092_abnormal_eye_morphology0.66880879
123MP0003634_abnormal_glial_cell0.65635094
124MP0003646_muscle_fatigue0.64194506
125MP0005379_endocrine/exocrine_gland_phen0.62572240
126MP0002233_abnormal_nose_morphology0.60205241
127MP0003942_abnormal_urinary_system0.59680695
128MP0002938_white_spotting0.58973537
129MP0003303_peritoneal_inflammation0.58648168

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macular pigmentation (HP:0008002)6.25236308
2Focal motor seizures (HP:0011153)5.44508979
3Myokymia (HP:0002411)5.01207069
4Facial shape deformation (HP:0011334)4.92811067
5Potter facies (HP:0002009)4.92811067
6Optic nerve coloboma (HP:0000588)4.81490258
7Focal seizures (HP:0007359)4.52102175
8Metaphyseal dysplasia (HP:0100255)3.86468500
9Epileptic encephalopathy (HP:0200134)3.83731071
10Hepatoblastoma (HP:0002884)3.74314311
11Amblyopia (HP:0000646)3.72052701
12Abnormality of the lower motor neuron (HP:0002366)3.67231084
13* Supranuclear gaze palsy (HP:0000605)3.65935228
14Anomalous pulmonary venous return (HP:0010772)3.60993970
15Neoplasm of the adrenal cortex (HP:0100641)3.52261524
16Rib fusion (HP:0000902)3.50138512
17Renal dysplasia (HP:0000110)3.45236394
18Bicornuate uterus (HP:0000813)3.43823295
19Neonatal hypoglycemia (HP:0001998)3.31203068
20Adrenal hypoplasia (HP:0000835)3.23360706
21Abnormality of the labia minora (HP:0012880)3.18838473
22Broad-based gait (HP:0002136)3.16978550
23Vaginal atresia (HP:0000148)3.14098337
24Abnormality of the pulmonary veins (HP:0011718)3.10315243
25Renal hypoplasia (HP:0000089)3.10104102
26Atonic seizures (HP:0010819)3.02652763
27Diastasis recti (HP:0001540)3.02595361
28Horseshoe kidney (HP:0000085)3.01725451
29Impaired vibration sensation in the lower limbs (HP:0002166)2.97674644
30Genital tract atresia (HP:0001827)2.97319329
31Hemiparesis (HP:0001269)2.93632382
32Chronic hepatic failure (HP:0100626)2.80927684
33Visual hallucinations (HP:0002367)2.80887557
34Focal segmental glomerulosclerosis (HP:0000097)2.80769074
35Febrile seizures (HP:0002373)2.77692357
36Morphological abnormality of the middle ear (HP:0008609)2.74855048
37Growth hormone deficiency (HP:0000824)2.72205388
38Generalized tonic-clonic seizures (HP:0002069)2.69969253
39Abnormal pancreas size (HP:0012094)2.69725055
40Insomnia (HP:0100785)2.68818871
41Short 4th metacarpal (HP:0010044)2.67438160
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.67438160
43Long foot (HP:0001833)2.65735263
44Drooling (HP:0002307)2.65262282
45Excessive salivation (HP:0003781)2.65262282
46Abnormality of the corticospinal tract (HP:0002492)2.65200476
47Spastic tetraplegia (HP:0002510)2.64499991
48Hypoventilation (HP:0002791)2.57439359
49Abnormality of the nasal septum (HP:0000419)2.56076623
50Hyperacusis (HP:0010780)2.55081084
51Anosmia (HP:0000458)2.54669522
52Shawl scrotum (HP:0000049)2.54171393
53Exotropia (HP:0000577)2.54128323
54Dialeptic seizures (HP:0011146)2.53134198
55Macular degeneration (HP:0000608)2.49644927
56Exostoses (HP:0100777)2.49518802
57Agitation (HP:0000713)2.48530821
58Absence seizures (HP:0002121)2.47124169
59Abnormal eating behavior (HP:0100738)2.45338731
60Pointed chin (HP:0000307)2.43713698
61Esotropia (HP:0000565)2.41398486
62Epileptiform EEG discharges (HP:0011182)2.40920405
63Amaurosis fugax (HP:0100576)2.37959798
64Abnormality of the 1st metacarpal (HP:0010009)2.37827655
65Occipital encephalocele (HP:0002085)2.36199329
66Prolonged QT interval (HP:0001657)2.36044725
67Spastic tetraparesis (HP:0001285)2.34180538
68Elfin facies (HP:0004428)2.31983158
69EEG with generalized epileptiform discharges (HP:0011198)2.31593849
70Severe visual impairment (HP:0001141)2.30913270
71Hypsarrhythmia (HP:0002521)2.30648965
72Spastic gait (HP:0002064)2.30231631
73Ankyloglossia (HP:0010296)2.29960664
74Short 1st metacarpal (HP:0010034)2.29739771
75Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.29739771
76Polyphagia (HP:0002591)2.29316170
77Chorioretinal coloboma (HP:0000567)2.28796359
78White forelock (HP:0002211)2.28559244
79Amyotrophic lateral sclerosis (HP:0007354)2.25405483
80Insidious onset (HP:0003587)2.23350550
81Termporal pattern (HP:0011008)2.23350550
82Hydroureter (HP:0000072)2.22980509
83Stereotypic behavior (HP:0000733)2.22708837
84Abnormality of the intervertebral disk (HP:0005108)2.22364904
85Hypogonadotrophic hypogonadism (HP:0000044)2.21673332
86Midline defect of the nose (HP:0004122)2.20751876
87Cortical dysplasia (HP:0002539)2.19069162
88Urinary urgency (HP:0000012)2.18414092
89Deep palmar crease (HP:0006191)2.17174172
90Overgrowth (HP:0001548)2.17145635
91Hyperventilation (HP:0002883)2.16997955
92Degeneration of the lateral corticospinal tracts (HP:0002314)2.16921540
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16921540
94Anophthalmia (HP:0000528)2.14954779
95Urinary bladder sphincter dysfunction (HP:0002839)2.14614546
96Primary amenorrhea (HP:0000786)2.14114045
97Patchy hypopigmentation of hair (HP:0011365)2.13110265
98Tubulointerstitial nephritis (HP:0001970)2.12188700
99Renal agenesis (HP:0000104)2.10887674
100Ectopia lentis (HP:0001083)2.09519024
101Wrist flexion contracture (HP:0001239)2.08571338
102Lymphangioma (HP:0100764)2.08568060
103Retinal dysplasia (HP:0007973)2.07634578
104Abnormality of cells of the erythroid lineage (HP:0012130)2.07551546
105Apathy (HP:0000741)2.06032035
106Hand muscle atrophy (HP:0009130)2.03963870
107Anencephaly (HP:0002323)2.03718563
108Prominent occiput (HP:0000269)2.03436802
109Failure to thrive in infancy (HP:0001531)2.02562386
110Chorioretinal atrophy (HP:0000533)2.01789724
111Disproportionate short-trunk short stature (HP:0003521)2.01563603
112Cutaneous finger syndactyly (HP:0010554)2.01101171
113Soft skin (HP:0000977)2.00961832
114Hypoplasia of the brainstem (HP:0002365)1.99825175
115Aplasia/Hypoplasia of the brainstem (HP:0007362)1.99825175
116Glomerulosclerosis (HP:0000096)1.99482906
117Hyperthyroidism (HP:0000836)1.99481875
118Decreased lacrimation (HP:0000633)1.98706664
119Focal dystonia (HP:0004373)1.98300264
120Diminished motivation (HP:0000745)1.96321499
121Alacrima (HP:0000522)1.96184076
122Facial hemangioma (HP:0000329)1.95680953
123Abnormality of the 4th metacarpal (HP:0010012)1.95054165
124Autism (HP:0000717)1.94809871
125Meningocele (HP:0002435)1.94021892
126Poor eye contact (HP:0000817)1.93944451
127Hemiplegia (HP:0002301)1.93821073
128Pancreatic fibrosis (HP:0100732)1.93348324
129Nephronophthisis (HP:0000090)1.92584750
130Ventricular fibrillation (HP:0001663)1.92550187
131Reticulocytopenia (HP:0001896)1.90637375
132Depression (HP:0000716)1.90148082
133Vesicoureteral reflux (HP:0000076)1.89831628
134Ankle clonus (HP:0011448)1.89783253
135Patent foramen ovale (HP:0001655)1.89012479
136Obsessive-compulsive behavior (HP:0000722)1.88259995
137Truncus arteriosus (HP:0001660)1.88228088
138Cerebral inclusion bodies (HP:0100314)1.86359971
139Lissencephaly (HP:0001339)1.86055900
140Hypoplasia of the iris (HP:0007676)1.85879773
141Pendular nystagmus (HP:0012043)1.85452084
142Abnormal social behavior (HP:0012433)1.85207775
143Impaired social interactions (HP:0000735)1.85207775
144Abnormality of salivation (HP:0100755)1.84676055
145Heterochromia iridis (HP:0001100)1.84538188
146Hypoplasia of the corpus callosum (HP:0002079)1.84245672
147Macroorchidism (HP:0000053)1.83463351
148Craniofacial dystonia (HP:0012179)1.83344265
149Fetal akinesia sequence (HP:0001989)1.82478423
150Nasolacrimal duct obstruction (HP:0000579)1.82200518
151Wide cranial sutures (HP:0010537)1.81578022
152Epiphyseal dysplasia (HP:0002656)1.81572211
153Lip pit (HP:0100267)1.81334349
154Progressive cerebellar ataxia (HP:0002073)1.81277028
155Inappropriate behavior (HP:0000719)1.80893121
156Multicystic kidney dysplasia (HP:0000003)1.79471625
157Myotonia (HP:0002486)1.79315007
158Hip dysplasia (HP:0001385)1.79284866
159Hypoplastic nipples (HP:0002557)1.78982839
160Overriding aorta (HP:0002623)1.78020522
161Pachygyria (HP:0001302)1.77774231
162Polymicrogyria (HP:0002126)1.77539760
163Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77371110
164Stage 5 chronic kidney disease (HP:0003774)1.77330234
165Neurofibrillary tangles (HP:0002185)1.77229598
166Impaired smooth pursuit (HP:0007772)1.74614174
167Enlarged kidneys (HP:0000105)1.72990955
168Abnormal number of erythroid precursors (HP:0012131)1.71742769
169Axonal loss (HP:0003447)1.67785781
170Molar tooth sign on MRI (HP:0002419)1.66488658
171Abnormality of midbrain morphology (HP:0002418)1.66488658
172True hermaphroditism (HP:0010459)1.66074749
173Megalencephaly (HP:0001355)1.65974782
174Gait imbalance (HP:0002141)1.64276891
175Restlessness (HP:0000711)1.63907405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK25.55723361
2MARK14.98203347
3EPHA43.36256674
4NTRK32.96614747
5PAK62.71942827
6TNIK2.51577899
7MAP3K92.41176333
8PNCK2.18072811
9ARAF2.16965950
10NTRK22.04437457
11DYRK22.00021055
12DAPK21.94107959
13MAPK131.93799331
14MAP3K41.89959673
15KSR11.79713787
16CAMK1G1.71001240
17MINK11.62811301
18ADRBK21.62040222
19UHMK11.57023464
20EPHB21.56549151
21PIM21.53607351
22INSRR1.53254078
23DYRK31.51059406
24KSR21.48083083
25CDK51.46437799
26ICK1.44882090
27MAP3K111.43860869
28MAP2K71.38184114
29RPS6KL11.33860133
30RPS6KC11.33860133
31RPS6KA61.29397959
32CAMKK11.29006926
33ERBB31.24096929
34MARK21.23035669
35LIMK11.16609259
36RPS6KA21.16537250
37CSNK1G21.12692723
38CDC42BPA1.10431444
39PINK11.10418222
40CASK1.09730321
41DYRK1B1.08686715
42CDK191.07385024
43BRAF1.07327859
44FES1.04197173
45SGK2231.02230890
46SGK4941.02230890
47PRKCH1.01123055
48TRIB30.99523014
49TYRO30.99519784
50MKNK20.99244784
51SGK20.97254079
52RIPK40.96623926
53ERBB20.92598489
54CSNK1A1L0.92106733
55NME10.92000539
56TESK20.90615225
57STK110.90032899
58MAP2K40.89922601
59PRKD20.87378044
60CSNK1G30.87250356
61DYRK1A0.87144786
62FGR0.85943988
63PAK30.85684512
64BMPR1B0.85220492
65PKN10.84136038
66BTK0.83254741
67PRKD30.82068758
68DAPK10.78177765
69NTRK10.75293583
70PRKCG0.73701713
71PTK2B0.72618141
72CAMK2A0.71383608
73GRK10.71028180
74CAMK10.70775682
75CDK150.67222203
76TAF10.66441551
77ZAK0.65996327
78CDK180.65542493
79CAMK40.65297690
80PRKD10.65241603
81CDK90.63795943
82WNK30.62082203
83CDK11A0.61210100
84CDK140.60822889
85BRD40.60267218
86RIPK10.59665790
87RET0.59533218
88CAMK2B0.59530190
89MAPK80.58671899
90FYN0.57104453
91PRKCZ0.56910660
92TAOK10.56386840
93MKNK10.55715671
94ROCK20.55632764
95OXSR10.54622114
96SGK30.54307069
97PRKAA10.54058021
98MAP3K130.53832794
99SIK30.53491342
100CAMKK20.52415716
101PHKG20.52405402
102PHKG10.52405402
103WNK10.52000224
104CSNK1G10.51783215
105MAP3K70.51746655
106PLK20.51193860
107HCK0.50116221
108RPS6KA10.49159044
109ROCK10.48389366
110AKT10.47933859
111GRK50.46762904
112HIPK20.44347155
113MAP2K20.44311221
114ALK0.44260210
115PRKCI0.44204429
116MAP3K20.43762169
117MAP2K10.43716744
118WNK40.43448521
119SGK10.42655136
120FGFR20.41590495
121PTK60.41556919
122STK390.41467316
123STK380.40386556
124BCKDK0.40155201
125CAMK1D0.40080381
126MTOR0.38961359
127CSNK1E0.38958471
128PRKACA0.38621026
129CDK30.38450933
130MAPK90.37756761
131PRKG10.37724335
132DDR20.37671623
133SIK10.37013293
134LRRK20.36423992
135DMPK0.36137991
136MAPK110.35585815
137ITK0.35291731
138PRKCQ0.35191939
139ADRBK10.35075805
140MAP3K60.34490727
141CHUK0.28346199
142ABL20.27904596
143PTK20.27795121
144TESK10.26983370
145SRC0.26832875

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77981403
2Sulfur relay system_Homo sapiens_hsa041223.13076717
3Glutamatergic synapse_Homo sapiens_hsa047242.68741781
4Circadian entrainment_Homo sapiens_hsa047132.56677207
5Synaptic vesicle cycle_Homo sapiens_hsa047212.49849585
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42838634
7* Axon guidance_Homo sapiens_hsa043602.37566550
8GABAergic synapse_Homo sapiens_hsa047272.27188086
9Morphine addiction_Homo sapiens_hsa050322.14923433
10Long-term potentiation_Homo sapiens_hsa047202.13965559
11Amphetamine addiction_Homo sapiens_hsa050312.05517320
12Cocaine addiction_Homo sapiens_hsa050302.00901387
13Ribosome_Homo sapiens_hsa030101.96209167
14Dopaminergic synapse_Homo sapiens_hsa047281.94399544
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93948681
16Olfactory transduction_Homo sapiens_hsa047401.91592956
17Parkinsons disease_Homo sapiens_hsa050121.91119844
18Salivary secretion_Homo sapiens_hsa049701.89873634
19Insulin secretion_Homo sapiens_hsa049111.84877862
20Cholinergic synapse_Homo sapiens_hsa047251.83145715
21Gastric acid secretion_Homo sapiens_hsa049711.76507357
22Oxidative phosphorylation_Homo sapiens_hsa001901.74903822
23Oxytocin signaling pathway_Homo sapiens_hsa049211.71421155
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71370588
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71328271
26Gap junction_Homo sapiens_hsa045401.57439843
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57110191
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54827720
29Long-term depression_Homo sapiens_hsa047301.52882767
30Renin secretion_Homo sapiens_hsa049241.51625827
31Serotonergic synapse_Homo sapiens_hsa047261.39403409
32Type II diabetes mellitus_Homo sapiens_hsa049301.39304683
33Melanogenesis_Homo sapiens_hsa049161.37160449
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34855979
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32848335
36Taste transduction_Homo sapiens_hsa047421.31048403
37Alzheimers disease_Homo sapiens_hsa050101.28597057
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26667218
39Huntingtons disease_Homo sapiens_hsa050161.25081760
40Calcium signaling pathway_Homo sapiens_hsa040201.19542995
41ErbB signaling pathway_Homo sapiens_hsa040121.15924018
42cAMP signaling pathway_Homo sapiens_hsa040241.15579033
43Cardiac muscle contraction_Homo sapiens_hsa042601.13394213
44Wnt signaling pathway_Homo sapiens_hsa043101.07443017
45Glioma_Homo sapiens_hsa052141.04461521
46Estrogen signaling pathway_Homo sapiens_hsa049151.04199840
47GnRH signaling pathway_Homo sapiens_hsa049120.96886363
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96186246
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95583673
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93553339
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92168053
52Dilated cardiomyopathy_Homo sapiens_hsa054140.92166961
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91754855
54Basal cell carcinoma_Homo sapiens_hsa052170.87480804
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86707095
56Colorectal cancer_Homo sapiens_hsa052100.86305444
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85868826
58Regulation of autophagy_Homo sapiens_hsa041400.85682278
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85070797
60Endometrial cancer_Homo sapiens_hsa052130.84616549
61Nitrogen metabolism_Homo sapiens_hsa009100.83880416
62Rap1 signaling pathway_Homo sapiens_hsa040150.83090012
63Endocytosis_Homo sapiens_hsa041440.82271937
64Phototransduction_Homo sapiens_hsa047440.81849140
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.80877447
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79459181
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79060834
68Choline metabolism in cancer_Homo sapiens_hsa052310.78378718
69VEGF signaling pathway_Homo sapiens_hsa043700.76790424
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74113712
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73214967
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73171360
73MAPK signaling pathway_Homo sapiens_hsa040100.72278465
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71888495
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.70632729
76Renal cell carcinoma_Homo sapiens_hsa052110.70486689
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69738364
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69324692
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68019715
80Bile secretion_Homo sapiens_hsa049760.67378443
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.66026220
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65557371
83Collecting duct acid secretion_Homo sapiens_hsa049660.65476389
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63592985
85Dorso-ventral axis formation_Homo sapiens_hsa043200.61598314
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61313001
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60598691
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60276222
89Pancreatic secretion_Homo sapiens_hsa049720.60001380
90Ras signaling pathway_Homo sapiens_hsa040140.58380966
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58268737
92Alcoholism_Homo sapiens_hsa050340.57857170
93p53 signaling pathway_Homo sapiens_hsa041150.56703061
94Basal transcription factors_Homo sapiens_hsa030220.56556194
95Hippo signaling pathway_Homo sapiens_hsa043900.56250179
96Oocyte meiosis_Homo sapiens_hsa041140.56188946
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55680870
98Ether lipid metabolism_Homo sapiens_hsa005650.54876145
99Steroid biosynthesis_Homo sapiens_hsa001000.54415654
100Folate biosynthesis_Homo sapiens_hsa007900.53918215
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53908191
102mTOR signaling pathway_Homo sapiens_hsa041500.52974420
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52523219
104Glucagon signaling pathway_Homo sapiens_hsa049220.50792188
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.50509145
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.49126502
107Prion diseases_Homo sapiens_hsa050200.49010512
108Ovarian steroidogenesis_Homo sapiens_hsa049130.48576610
109Lysine degradation_Homo sapiens_hsa003100.48396573
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47898429
111Non-small cell lung cancer_Homo sapiens_hsa052230.47316480
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.44346442
113Prolactin signaling pathway_Homo sapiens_hsa049170.43655856
114Circadian rhythm_Homo sapiens_hsa047100.43577004
115Phagosome_Homo sapiens_hsa041450.43089324
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42919156
117Viral myocarditis_Homo sapiens_hsa054160.41239129
118Chronic myeloid leukemia_Homo sapiens_hsa052200.40863497
119Platelet activation_Homo sapiens_hsa046110.39814213
120Notch signaling pathway_Homo sapiens_hsa043300.39175165
121Hedgehog signaling pathway_Homo sapiens_hsa043400.39077220
122Butanoate metabolism_Homo sapiens_hsa006500.38938953
123Thyroid hormone synthesis_Homo sapiens_hsa049180.37132880
124Insulin signaling pathway_Homo sapiens_hsa049100.37104173
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36510148

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