ROBO4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)9.55394491
2vascular endothelial growth factor signaling pathway (GO:0038084)8.32367609
3endothelium development (GO:0003158)7.75087180
4lymphangiogenesis (GO:0001946)7.10732991
5cellular response to vascular endothelial growth factor stimulus (GO:0035924)6.54038088
6wound healing, spreading of epidermal cells (GO:0035313)6.00977169
7positive regulation of vasculogenesis (GO:2001214)5.83882784
8retina vasculature morphogenesis in camera-type eye (GO:0061299)5.45522244
9blood vessel maturation (GO:0001955)5.10877510
10ovulation from ovarian follicle (GO:0001542)5.04908076
11surfactant homeostasis (GO:0043129)5.04396698
12vascular endothelial growth factor receptor signaling pathway (GO:0048010)5.01808649
13sprouting angiogenesis (GO:0002040)4.98182799
14endothelial tube morphogenesis (GO:0061154)4.91391416
15morphogenesis of an endothelium (GO:0003159)4.91391416
16endothelial cell differentiation (GO:0045446)4.89690488
17transcytosis (GO:0045056)4.86845243
18peptidyl-tyrosine autophosphorylation (GO:0038083)4.84317471
19regulation of vasculogenesis (GO:2001212)4.80342293
20negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.63881243
21regulation of endothelial cell differentiation (GO:0045601)4.60525315
22heart trabecula formation (GO:0060347)4.57017355
23patterning of blood vessels (GO:0001569)4.42760565
24blood vessel endothelial cell migration (GO:0043534)4.32629805
25artery development (GO:0060840)4.17452526
26basement membrane organization (GO:0071711)4.14241399
27positive regulation of urine volume (GO:0035810)4.07322050
28wound healing, spreading of cells (GO:0044319)4.05158904
29cell migration involved in sprouting angiogenesis (GO:0002042)4.04569221
30negative regulation of endothelial cell apoptotic process (GO:2000352)3.98464451
31negative regulation of blood vessel endothelial cell migration (GO:0043537)3.93934004
32glomerular filtration (GO:0003094)3.93063123
33positive regulation of receptor recycling (GO:0001921)3.89354487
34chemical homeostasis within a tissue (GO:0048875)3.84936188
35endothelial cell morphogenesis (GO:0001886)3.80446488
36vasculogenesis (GO:0001570)3.78867504
37positive regulation of odontogenesis (GO:0042482)3.76050557
38regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.75836245
39regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.73236316
40negative regulation of adherens junction organization (GO:1903392)3.66875256
41negative regulation of focal adhesion assembly (GO:0051895)3.66875256
42negative regulation of cell junction assembly (GO:1901889)3.66875256
43venous blood vessel morphogenesis (GO:0048845)3.64195183
44renal filtration (GO:0097205)3.61737566
45regulation of glomerular filtration (GO:0003093)3.61035297
46negative regulation of endothelial cell migration (GO:0010596)3.60854408
47cell migration involved in heart development (GO:0060973)3.52677129
48regulation of cellular extravasation (GO:0002691)3.51920858
49embryonic heart tube development (GO:0035050)3.50783997
50establishment of endothelial barrier (GO:0061028)3.46823066
51definitive hemopoiesis (GO:0060216)3.40724090
52cell adhesion mediated by integrin (GO:0033627)3.38115384
53positive regulation of glomerulus development (GO:0090193)3.37300665
54nephron epithelium development (GO:0072009)3.35477914
55positive regulation of blood vessel endothelial cell migration (GO:0043536)3.33985937
56negative regulation of vascular permeability (GO:0043116)3.31946756
57negative regulation of DNA biosynthetic process (GO:2000279)3.31485363
58regulation of sequestering of triglyceride (GO:0010889)3.27931078
59regulation of endothelial cell apoptotic process (GO:2000351)3.27794780
60positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.23357830
61hyaluronan catabolic process (GO:0030214)3.20406417
62neuron remodeling (GO:0016322)3.19690161
63negative regulation of platelet activation (GO:0010544)3.17861931
64semaphorin-plexin signaling pathway (GO:0071526)3.17259568
65substrate-dependent cell migration (GO:0006929)3.11873994
66positive regulation of cell junction assembly (GO:1901890)3.11603077
67positive regulation of focal adhesion assembly (GO:0051894)3.11603077
68endothelial cell migration (GO:0043542)3.11536501
69fatty acid transmembrane transport (GO:1902001)3.10810345
70regulation of endothelial cell migration (GO:0010594)3.10456597
71regulation of urine volume (GO:0035809)3.08934991
72negative regulation of nitric-oxide synthase activity (GO:0051001)3.07636725
73arginine catabolic process (GO:0006527)3.04057229
74positive regulation of endothelial cell proliferation (GO:0001938)3.03767247
75positive regulation of endothelial cell migration (GO:0010595)3.02619967
76regulation of vascular permeability (GO:0043114)2.99413926
77plasma membrane repair (GO:0001778)2.95905045
78positive regulation of epithelial cell migration (GO:0010634)2.93005189
79angiogenesis involved in wound healing (GO:0060055)2.92231810
80negative regulation of epithelial cell migration (GO:0010633)2.91548788
81anatomical structure maturation (GO:0071695)2.90164554
82negative regulation of chondrocyte differentiation (GO:0032331)2.88589448
83extracellular fibril organization (GO:0043206)2.87097111
84sarcomere organization (GO:0045214)2.86807037
85positive regulation of adherens junction organization (GO:1903393)2.86227545
86negative regulation of protein autophosphorylation (GO:0031953)2.86152829
87trabecula morphogenesis (GO:0061383)2.84419478
88low-density lipoprotein particle clearance (GO:0034383)2.84371753
89negative regulation of anoikis (GO:2000811)2.83646605
90endothelial cell chemotaxis (GO:0035767)2.83502941
91regulation of endothelial cell proliferation (GO:0001936)2.82979589
92trabecula formation (GO:0060343)2.82750358
93negative regulation of angiogenesis (GO:0016525)2.82611549
94cardiac myofibril assembly (GO:0055003)2.81319238
95regulation of blood vessel endothelial cell migration (GO:0043535)2.81115025
96endothelial cell proliferation (GO:0001935)2.80081705
97negative regulation of blood vessel morphogenesis (GO:2000181)2.80052247
98positive regulation of interleukin-8 secretion (GO:2000484)2.78472291
99positive regulation of protein kinase C signaling (GO:0090037)2.77783989
100mRNA transcription from RNA polymerase II promoter (GO:0042789)2.76497315
101positive regulation of endothelial cell apoptotic process (GO:2000353)2.75555039
102detection of bacterium (GO:0016045)2.75152552
103ovulation (GO:0030728)2.74836850
104regulation of epithelial cell migration (GO:0010632)2.74043467
105coronary vasculature morphogenesis (GO:0060977)2.73264660
106negative regulation of cartilage development (GO:0061037)2.72931648
107negative regulation of Rho protein signal transduction (GO:0035024)2.72244902
108positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.71014566
109protein kinase C signaling (GO:0070528)2.70918365
110endochondral ossification (GO:0001958)2.70911561
111replacement ossification (GO:0036075)2.70911561
112positive regulation of cartilage development (GO:0061036)2.70162030
113blood vessel remodeling (GO:0001974)2.69512578
114positive regulation of endothelial cell differentiation (GO:0045603)2.68798294
115regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.68725176
116endocrine process (GO:0050886)2.68725176
117regulation of systemic arterial blood pressure by hormone (GO:0001990)2.68725176
118mRNA transcription (GO:0009299)2.68321271
119negative regulation of vasculature development (GO:1901343)2.67079291
120bundle of His cell to Purkinje myocyte communication (GO:0086069)2.66448501
121positive regulation of chondrocyte differentiation (GO:0032332)2.66040073
122carnitine shuttle (GO:0006853)2.65216210
123regulation of establishment or maintenance of cell polarity (GO:0032878)2.64778323
124negative regulation of endothelial cell proliferation (GO:0001937)2.64272510
125cell volume homeostasis (GO:0006884)2.64130467
126adhesion of symbiont to host (GO:0044406)2.62573081
127* angiogenesis (GO:0001525)2.61492228
128SMAD protein complex assembly (GO:0007183)2.60529659
129phagocytosis, recognition (GO:0006910)2.60412698
130cell proliferation involved in metanephros development (GO:0072203)2.59919732
131atrioventricular valve morphogenesis (GO:0003181)2.58177030
132cell-substrate junction assembly (GO:0007044)2.58108698
133endodermal cell differentiation (GO:0035987)2.56961751
134cAMP biosynthetic process (GO:0006171)2.55849707
135exocrine pancreas development (GO:0031017)2.53633583
136axon extension involved in axon guidance (GO:0048846)2.52821550
137neuron projection extension involved in neuron projection guidance (GO:1902284)2.52821550
138response to mercury ion (GO:0046689)2.52529511
139cGMP-mediated signaling (GO:0019934)2.51366010
140ventricular trabecula myocardium morphogenesis (GO:0003222)2.51201066
141heart trabecula morphogenesis (GO:0061384)2.50108032
142sodium-independent organic anion transport (GO:0043252)2.50066452
143interleukin-6-mediated signaling pathway (GO:0070102)2.49388504
144regulation of cholesterol storage (GO:0010885)2.49213300
145blood vessel morphogenesis (GO:0048514)2.48842695
146detection of other organism (GO:0098543)2.48834317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.64402127
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.25401616
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.20106381
4* GATA2_21666600_ChIP-Seq_HMVEC_Human4.00003451
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.80610043
6CLOCK_20551151_ChIP-Seq_293T_Human3.49808680
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.90666029
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.88270028
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.87684752
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66813741
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48716023
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.43319198
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.40534097
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.39294617
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.38324978
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35169445
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32428335
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.10532254
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02433339
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.01441411
21TBX20_22328084_ChIP-Seq_HEART_Mouse1.99770482
22TBX20_22080862_ChIP-Seq_HEART_Mouse1.99770482
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85397285
24SCL_19346495_ChIP-Seq_HPC-7_Human1.80707888
25GATA1_19941826_ChIP-Seq_K562_Human1.80097690
26* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74319604
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.73640416
28SALL4_18804426_ChIP-ChIP_XEN_Mouse1.72686037
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.72213451
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70692707
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.70587034
32ZNF263_19887448_ChIP-Seq_K562_Human1.70255793
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70206176
34EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.68806445
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67849072
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.65134563
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64617042
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63724585
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.63039106
40GATA1_22025678_ChIP-Seq_K562_Human1.62303327
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.49880992
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49548780
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47993545
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47993545
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43891883
46RUNX_20019798_ChIP-Seq_JUKART_Human1.42716893
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.42195409
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.42195409
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.42195409
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36270049
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33150876
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.28955874
53SMC3_22415368_ChIP-Seq_MEFs_Mouse1.26015974
54SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21130705
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21015485
56FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.20631467
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20173199
58* TP53_23651856_ChIP-Seq_MEFs_Mouse1.16412432
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16303176
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15878814
61CDX2_20551321_ChIP-Seq_CACO-2_Human1.15183663
62SMC1_22415368_ChIP-Seq_MEFs_Mouse1.14954123
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13443412
64PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13401468
65SOX2_20726797_ChIP-Seq_SW620_Human1.13167750
66* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12616794
67CJUN_26792858_Chip-Seq_BT549_Human1.11554353
68* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11548815
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11181200
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10847449
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09794397
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.09746839
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09606085
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.08102635
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07709901
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.07462032
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04352647
78NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03076153
79BRD4_25478319_ChIP-Seq_HGPS_Human1.02997716
80GATA2_19941826_ChIP-Seq_K562_Human1.02984497
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02706645
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02442110
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02149742
84* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01219861
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00668238
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00668238
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00204019
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99786917
89WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98590348
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98016194
91STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97522225
92TET1_21490601_ChIP-Seq_MESCs_Mouse0.96828003
93SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95505908
94UBF1/2_26484160_Chip-Seq_HMECs_Human0.94834500
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94672951
96TCF4_18268006_ChIP-ChIP_LS174T_Human0.94512508
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94055737
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92797645
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92646900
100P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92541929
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92257226
102RACK7_27058665_Chip-Seq_MCF-7_Human0.92202244
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91385696
104MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.90873774
105* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90791359
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90176406
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90129060
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89835600
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89637690
110* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88109422
111SA1_22415368_ChIP-Seq_MEFs_Mouse0.87300963
112KDM2B_26808549_Chip-Seq_DND41_Human0.86835073
113RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86625464
114SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86116276
115EZH2_27294783_Chip-Seq_ESCs_Mouse0.85165087
116TP53_22127205_ChIP-Seq_IMR90_Human0.84261641
117LXR_22292898_ChIP-Seq_THP-1_Human0.84210604
118SPI1_23127762_ChIP-Seq_K562_Human0.83755397
119RXR_22108803_ChIP-Seq_LS180_Human0.83393972
120TCF7_22412390_ChIP-Seq_EML_Mouse0.82497222
121* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82460743
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81642619
123PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.81412243
124KDM2B_26808549_Chip-Seq_K562_Human0.81208712
125PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80114476
126DROSHA_22980978_ChIP-Seq_HELA_Human0.79815130
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.79094146
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79067420
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78375666
130WT1_19549856_ChIP-ChIP_CCG9911_Human0.78163704
131ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77081042
132NCOR1_26117541_ChIP-Seq_K562_Human0.75598150
133SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.75284011

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system7.61016498
2MP0001879_abnormal_lymphatic_vessel5.92387674
3MP0005167_abnormal_blood-brain_barrier4.33078143
4MP0004272_abnormal_basement_membrane3.92967144
5MP0003724_increased_susceptibility_to3.50766531
6MP0003828_pulmonary_edema3.10374802
7MP0004147_increased_porphyrin_level3.08373392
8MP0004084_abnormal_cardiac_muscle3.08223519
9MP0006054_spinal_hemorrhage3.01200139
10MP0009278_abnormal_bone_marrow2.72298439
11MP0004215_abnormal_myocardial_fiber2.54816436
12MP0005670_abnormal_white_adipose2.22836889
13MP0000013_abnormal_adipose_tissue2.22109773
14MP0009379_abnormal_foot_pigmentation2.20832532
15MP0010030_abnormal_orbit_morphology2.13661178
16MP0006138_congestive_heart_failure2.10937133
17MP0003191_abnormal_cellular_cholesterol2.09744433
18MP0004036_abnormal_muscle_relaxation1.91564934
19MP0002877_abnormal_melanocyte_morpholog1.86423651
20MP0003705_abnormal_hypodermis_morpholog1.79786575
21MP0003300_gastrointestinal_ulcer1.79305733
22MP0004145_abnormal_muscle_electrophysio1.77041069
23MP0000751_myopathy1.76631605
24MP0002837_dystrophic_cardiac_calcinosis1.73400063
25MP0005330_cardiomyopathy1.69821111
26MP0000767_abnormal_smooth_muscle1.65311588
27MP0002933_joint_inflammation1.63257297
28MP0003279_aneurysm1.62053688
29MP0005360_urolithiasis1.58702798
30MP0001544_abnormal_cardiovascular_syste1.57363703
31MP0005385_cardiovascular_system_phenoty1.57363703
32MP0005397_hematopoietic_system_phenotyp1.56966162
33MP0001545_abnormal_hematopoietic_system1.56966162
34MP0004130_abnormal_muscle_cell1.54639914
35MP0003950_abnormal_plasma_membrane1.54004235
36MP0008775_abnormal_heart_ventricle1.51593696
37MP0010630_abnormal_cardiac_muscle1.49344252
38MP0004484_altered_response_of1.43711430
39MP0002127_abnormal_cardiovascular_syste1.43085558
40MP0002128_abnormal_blood_circulation1.41950633
41MP0005085_abnormal_gallbladder_physiolo1.41533688
42MP0005165_increased_susceptibility_to1.41391683
43MP0002332_abnormal_exercise_endurance1.37858249
44MP0002972_abnormal_cardiac_muscle1.36578999
45MP0005409_darkened_coat_color1.36162124
46MP0004233_abnormal_muscle_weight1.34852042
47MP0005365_abnormal_bile_salt1.31120658
48* MP0000249_abnormal_blood_vessel1.27795397
49MP0005595_abnormal_vascular_smooth1.26486294
50MP0008004_abnormal_stomach_pH1.22760954
51MP0004085_abnormal_heartbeat1.20989131
52MP0004510_myositis1.19736182
53MP0002138_abnormal_hepatobiliary_system1.18653928
54* MP0003091_abnormal_cell_migration1.18227974
55MP0005620_abnormal_muscle_contractility1.17987121
56MP0010329_abnormal_lipoprotein_level1.17163493
57MP0000343_altered_response_to1.16629455
58* MP0002925_abnormal_cardiovascular_devel1.14133646
59MP0003868_abnormal_feces_composition1.13837097
60MP0003943_abnormal_hepatobiliary_system1.13049210
61MP0005084_abnormal_gallbladder_morpholo1.12771626
62MP0009780_abnormal_chondrocyte_physiolo1.12418595
63MP0004087_abnormal_muscle_fiber1.10665233
64MP0001873_stomach_inflammation1.10571116
65MP0005275_abnormal_skin_tensile1.08749471
66* MP0001614_abnormal_blood_vessel1.08168012
67MP0000749_muscle_degeneration1.08046674
68MP0008875_abnormal_xenobiotic_pharmacok1.03963642
69MP0003566_abnormal_cell_adhesion1.03219727
70MP0001851_eye_inflammation1.02652104
71MP0000266_abnormal_heart_morphology1.02404639
72MP0000003_abnormal_adipose_tissue1.01666873
73MP0000759_abnormal_skeletal_muscle0.98217133
74MP0004808_abnormal_hematopoietic_stem0.95153606
75MP0002295_abnormal_pulmonary_circulatio0.94585465
76MP0003075_altered_response_to0.91637407
77MP0005666_abnormal_adipose_tissue0.87275045
78MP0000750_abnormal_muscle_regeneration0.87230856
79MP0005023_abnormal_wound_healing0.86673799
80MP0000230_abnormal_systemic_arterial0.85499297
81MP0005375_adipose_tissue_phenotype0.85162725
82MP0002971_abnormal_brown_adipose0.82693838
83MP0002139_abnormal_hepatobiliary_system0.82612613
84MP0003646_muscle_fatigue0.82318628
85MP0009697_abnormal_copulation0.81847194
86MP0000733_abnormal_muscle_development0.80512009
87MP0009840_abnormal_foam_cell0.80024155
88MP0000465_gastrointestinal_hemorrhage0.79399444
89MP0005623_abnormal_meninges_morphology0.78652233
90MP0001915_intracranial_hemorrhage0.78032409
91MP0002932_abnormal_joint_morphology0.77363853
92MP0004883_abnormal_blood_vessel0.76999823
93MP0000678_abnormal_parathyroid_gland0.76485226
94MP0005164_abnormal_response_to0.76321410
95MP0003567_abnormal_fetal_cardiomyocyte0.76040637
96MP0005319_abnormal_enzyme/_coenzyme0.73576502
97MP0003303_peritoneal_inflammation0.73279176
98MP0005388_respiratory_system_phenotype0.71247300
99MP0002133_abnormal_respiratory_system0.71247300
100MP0003948_abnormal_gas_homeostasis0.71126836
101* MP0001784_abnormal_fluid_regulation0.71030149
102MP0005166_decreased_susceptibility_to0.68935249
103MP0009115_abnormal_fat_cell0.68852759
104MP0003045_fibrosis0.68727496
105MP0008438_abnormal_cutaneous_collagen0.67967707
106MP0002896_abnormal_bone_mineralization0.67458515
107MP0008961_abnormal_basal_metabolism0.66891295
108MP0001849_ear_inflammation0.65963569
109MP0000609_abnormal_liver_physiology0.65521118
110MP0002396_abnormal_hematopoietic_system0.65098476
111MP0002166_altered_tumor_susceptibility0.64834932
112MP0005503_abnormal_tendon_morphology0.64746457
113MP0000598_abnormal_liver_morphology0.64744556
114MP0002106_abnormal_muscle_physiology0.64156677
115MP0005257_abnormal_intraocular_pressure0.64110465
116MP0003252_abnormal_bile_duct0.63832961
117MP0000747_muscle_weakness0.63402848
118MP0009764_decreased_sensitivity_to0.62488881
119MP0002086_abnormal_extraembryonic_tissu0.61958564
120MP0001756_abnormal_urination0.60940883
121MP0005508_abnormal_skeleton_morphology0.60359226
122MP0003385_abnormal_body_wall0.59665722
123MP0002168_other_aberrant_phenotype0.59336975
124MP0002118_abnormal_lipid_homeostasis0.58379529
125MP0005369_muscle_phenotype0.57426097
126MP0009643_abnormal_urine_homeostasis0.57351682
127MP0000049_abnormal_middle_ear0.57056181
128MP0002088_abnormal_embryonic_growth/wei0.56328464
129MP0009763_increased_sensitivity_to0.55112434
130MP0003984_embryonic_growth_retardation0.54157083
131MP0003959_abnormal_lean_body0.53924646
132MP0002108_abnormal_muscle_morphology0.53406053
133MP0001958_emphysema0.52650472
134MP0003935_abnormal_craniofacial_develop0.52573147
135MP0004782_abnormal_surfactant_physiolog0.52102748

Predicted human phenotypes

RankGene SetZ-score
1Nonimmune hydrops fetalis (HP:0001790)6.08367532
2Polycythemia (HP:0001901)5.38458790
3Spontaneous hematomas (HP:0007420)5.36297887
4Hematochezia (HP:0002573)4.84041489
5Esophageal varix (HP:0002040)4.77895528
6Wrist flexion contracture (HP:0001239)4.36880459
7Hypoglycemic coma (HP:0001325)4.13227132
8Ventricular tachycardia (HP:0004756)4.10987296
9Muscle fiber splitting (HP:0003555)4.06255220
10Lymphangioma (HP:0100764)3.99900565
11Broad metatarsal (HP:0001783)3.92012529
12Increased connective tissue (HP:0009025)3.77069553
13Asymmetry of the thorax (HP:0001555)3.71759429
14Arterial tortuosity (HP:0005116)3.68474222
15Deep venous thrombosis (HP:0002625)3.64704022
16Congenital, generalized hypertrichosis (HP:0004540)3.57778536
17Vascular tortuosity (HP:0004948)3.57546848
18Atrial fibrillation (HP:0005110)3.43578040
19Sudden death (HP:0001699)3.42123528
20Supraventricular arrhythmia (HP:0005115)3.29642199
21Conjunctival telangiectasia (HP:0000524)3.22067416
22Cerebral hemorrhage (HP:0001342)3.21557663
23Capillary hemangiomas (HP:0005306)3.20692282
24Primary atrial arrhythmia (HP:0001692)3.19947471
25Aortic aneurysm (HP:0004942)3.18394252
26Visceral angiomatosis (HP:0100761)3.12346085
27Hemangiomatosis (HP:0007461)3.11078175
28Lipoatrophy (HP:0100578)3.11039661
29Menorrhagia (HP:0000132)3.09849667
30Hyporeflexia of lower limbs (HP:0002600)3.06691256
31Supraventricular tachycardia (HP:0004755)3.04477278
32Myotonia (HP:0002486)3.04387792
33Portal hypertension (HP:0001409)3.03633338
34Adactyly (HP:0009776)3.02967036
35Premature rupture of membranes (HP:0001788)3.02794284
36Hemorrhage of the eye (HP:0011885)2.97556115
37Cerebral aneurysm (HP:0004944)2.96576842
38Pancreatic islet-cell hyperplasia (HP:0004510)2.93593552
39Hypoglycemic seizures (HP:0002173)2.92979882
40Joint hemorrhage (HP:0005261)2.88895061
41Abnormality of the nasal mucosa (HP:0000433)2.81444824
42Cervical subluxation (HP:0003308)2.78187466
43Difficulty running (HP:0009046)2.77342227
44Abnormality of the hepatic vasculature (HP:0006707)2.76252713
45Abnormality of the vasculature of the conjunctiva (HP:0008054)2.74948031
46Hyperinsulinemic hypoglycemia (HP:0000825)2.74450890
47Prolonged partial thromboplastin time (HP:0003645)2.69255540
48Abnormality of the intrinsic pathway (HP:0010989)2.67635451
49Facial diplegia (HP:0001349)2.67340083
50Aortic valve stenosis (HP:0001650)2.65252325
51Exercise-induced muscle cramps (HP:0003710)2.62654400
52Centrally nucleated skeletal muscle fibers (HP:0003687)2.60893093
53Overgrowth (HP:0001548)2.60130335
54Short hallux (HP:0010109)2.57817115
55Hip contracture (HP:0003273)2.57662516
56Spinal rigidity (HP:0003306)2.57604247
57Muscle stiffness (HP:0003552)2.54518374
58Acanthosis nigricans (HP:0000956)2.52928406
59Pulmonary hypertension (HP:0002092)2.52742251
60Cavernous hemangioma (HP:0001048)2.50284320
61Absent hand (HP:0004050)2.49980996
62Right ventricular cardiomyopathy (HP:0011663)2.49331320
63Skull defect (HP:0001362)2.48911995
64Aortic dissection (HP:0002647)2.47759732
65Dilated cardiomyopathy (HP:0001644)2.46318020
66Abnormality of skeletal muscle fiber size (HP:0012084)2.45408995
67Distal lower limb amyotrophy (HP:0008944)2.45168796
68Ketoacidosis (HP:0001993)2.43705278
69Ketosis (HP:0001946)2.43616877
70Shallow orbits (HP:0000586)2.42600262
71Abnormal platelet function (HP:0011869)2.41967599
72Impaired platelet aggregation (HP:0003540)2.41967599
73Porencephaly (HP:0002132)2.38746215
74Reduced subcutaneous adipose tissue (HP:0003758)2.38340185
75Aplasia/Hypoplasia of the hallux (HP:0008362)2.37109823
76Increased variability in muscle fiber diameter (HP:0003557)2.36604343
77Stroke (HP:0001297)2.35389344
78Microcytic anemia (HP:0001935)2.32600887
79Prolonged QT interval (HP:0001657)2.32466725
80Ectopia lentis (HP:0001083)2.31761030
81Insulin resistance (HP:0000855)2.31713745
82Mitral valve prolapse (HP:0001634)2.28653257
83Hypoalphalipoproteinemia (HP:0003233)2.27850314
84Growth hormone excess (HP:0000845)2.20754705
85Ileus (HP:0002595)2.19395452
86EMG: myopathic abnormalities (HP:0003458)2.18658812
87Wormian bones (HP:0002645)2.18324256
88Hypoplastic ischia (HP:0003175)2.17829813
89Atrioventricular block (HP:0001678)2.16733943
90Vertebral clefting (HP:0008428)2.15762528
91Joint contractures involving the joints of the feet (HP:0100492)2.15509786
92Flexion contracture of toe (HP:0005830)2.15509786
93Large hands (HP:0001176)2.14963313
94Pigmentary retinal degeneration (HP:0001146)2.14774106
95Abnormality of fatty-acid metabolism (HP:0004359)2.14437046
96Joint stiffness (HP:0001387)2.13341463
97Exercise-induced myalgia (HP:0003738)2.12427803
98Venous insufficiency (HP:0005293)2.11125003
99Broad face (HP:0000283)2.10574318
100Hypertriglyceridemia (HP:0002155)2.10418184
101Myoglobinuria (HP:0002913)2.10261051
102High pitched voice (HP:0001620)2.09495392
103Abnormal vertebral ossification (HP:0100569)2.09169822
104Mucosal telangiectasiae (HP:0100579)2.07683840
105Subaortic stenosis (HP:0001682)2.07456746
106Abnormality of the left ventricular outflow tract (HP:0011103)2.07456746
107Dicarboxylic aciduria (HP:0003215)2.07067991
108Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07067991
109Coxa vara (HP:0002812)2.06367007
110Pulmonary embolism (HP:0002204)2.05964080
111Neonatal death (HP:0003811)2.05878303
112Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.05797729
113Muscle fiber inclusion bodies (HP:0100299)2.04785332
114Lymphedema (HP:0001004)2.04592973
115Abnormality of the ischium (HP:0003174)2.04230664
116Limited hip movement (HP:0008800)2.03075685
117Nemaline bodies (HP:0003798)2.01276152
118Interstitial pulmonary disease (HP:0006530)2.00866455
119Hyperlipoproteinemia (HP:0010980)1.99786906
120Type 1 muscle fiber predominance (HP:0003803)1.99624524
121Pulmonary artery stenosis (HP:0004415)1.99132685
122Generalized muscle weakness (HP:0003324)1.98672831
123Hyperammonemia (HP:0001987)1.98629403
124Asymmetric septal hypertrophy (HP:0001670)1.98580621
125Venous abnormality (HP:0002624)1.98224449
126Aneurysm (HP:0002617)1.97354426
127Trismus (HP:0000211)1.96728535
128Difficulty climbing stairs (HP:0003551)1.96311744
129Polygenic inheritance (HP:0010982)1.95705607
130Malignant hyperthermia (HP:0002047)1.95343062
131Areflexia of lower limbs (HP:0002522)1.94405419
132Tetraparesis (HP:0002273)1.93724176
133Mesangial abnormality (HP:0001966)1.93139544
134Xanthomatosis (HP:0000991)1.92954273
135Round ear (HP:0100830)1.92565463
136Protrusio acetabuli (HP:0003179)1.92542349
137Absent toe (HP:0010760)1.92117307
138Large for gestational age (HP:0001520)1.90486635
139Distal lower limb muscle weakness (HP:0009053)1.88669164
140Neck muscle weakness (HP:0000467)1.88474747
141Myocardial infarction (HP:0001658)1.87259264
142Short nail (HP:0001799)1.87102244
143Epistaxis (HP:0000421)1.85076434
144Short 4th metacarpal (HP:0010044)1.84313886
145Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84313886
146Glucose intolerance (HP:0000833)1.81172788
147Hypoplasia of the iris (HP:0007676)1.80274448
148Striae distensae (HP:0001065)1.78792300
149Distal arthrogryposis (HP:0005684)1.77942136
150Blue sclerae (HP:0000592)1.77471066

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR8.66365339
2TGFBR23.41117349
3TGFBR12.58170911
4INSRR2.55625361
5GRK12.32520115
6TIE110.5294875
7PTK2B1.52719736
8RIPK11.49982573
9MYLK1.45496831
10ERN11.43563703
11MAP2K31.42332585
12NLK1.40776530
13TTN1.39851400
14NTRK11.33588366
15EPHB21.28764617
16BCKDK1.20537901
17PKN21.20209254
18CAMK1D1.18426609
19MAPK121.18028611
20EPHA21.16015326
21PRKG21.12994716
22TESK11.08668761
23TRPM71.07802093
24PDK21.04823468
25PTK61.02239173
26DMPK0.98728471
27MOS0.95744381
28FGFR40.94128754
29MAPK70.91402290
30PRKAA20.85263925
31EPHB10.84810275
32CAMK40.84341764
33MAP3K60.82410485
34TEC0.81893168
35TRIB30.79505408
36MAP3K30.78054202
37FLT30.78040491
38CAMK1G0.77554976
39FER0.76568493
40PDGFRA0.75743355
41FGFR20.73829032
42FRK0.71317353
43MAP2K20.69404725
44PAK40.67755290
45MAPK150.67129499
46PRKD10.65516632
47RPS6KA20.65402095
48EEF2K0.65388553
49LIMK10.61941003
50LMTK20.60547834
51JAK10.59455240
52FGFR30.59394424
53JAK30.59363422
54CSK0.58973761
55ROCK10.58783951
56OBSCN0.58781466
57MAP3K110.56401325
58LATS20.55382173
59PHKG10.54313938
60PHKG20.54313938
61DAPK30.53648369
62GRK50.53222076
63GSK3A0.52100847
64IGF1R0.51548627
65ROCK20.50558026
66SIK10.46675203
67TYK20.45135914
68STK380.45094322
69MAP4K10.43169064
70JAK20.43132532
71ARAF0.42890600
72PTK20.41183667
73LRRK20.40705300
74ICK0.40016531
75CDC42BPA0.39629559
76MAP3K10.38761993
77DDR20.38654402
78MAP3K70.38222224
79PINK10.38156449
80PRKCH0.36171405
81ITK0.34937105
82KIT0.34584419
83MAP3K130.32521173
84HCK0.31627201
85MAPKAPK50.31236225
86CDK90.31137449
87PDK40.30936085
88PDK30.30936085
89TBK10.30936035
90SRC0.30652991
91FES0.30607091
92NEK90.30543944
93MAP2K10.30527261
94CDK80.30126670
95SGK30.29052626
96MAPKAPK30.28511575
97DAPK20.27419809
98MATK0.27250506
99PRKAA10.26768323
100EGFR0.25778277
101MARK20.25238602
102WNK40.24871270
103SMG10.24374130
104IRAK30.24298515
105MAPK40.24211030
106PIK3CA0.23598656
107CAMK10.23571340
108ERBB40.23424240
109PRKD20.22531620
110RET0.22449689
111HIPK20.22322653
112INSR0.22294185
113PAK20.20109324
114SGK20.18853813
115CDK60.18823281
116DAPK10.18411595
117PRKCE0.16959528
118PRKD30.15491952
119TSSK60.15434379
120PDGFRB0.15330442
121MTOR0.15106508
122BTK0.14921129
123MET0.14547656
124ZAP700.14178991
125STK100.13269399
126ZAK0.13251321
127EPHA30.12572985
128PDPK10.12271356
129ILK0.11796434
130ABL20.10360863
131PRKACB0.09168450

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.96674090
2Arginine biosynthesis_Homo sapiens_hsa002202.76474463
3PPAR signaling pathway_Homo sapiens_hsa033202.61481563
4Fatty acid degradation_Homo sapiens_hsa000712.56571879
5Propanoate metabolism_Homo sapiens_hsa006402.50703688
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47932407
7Complement and coagulation cascades_Homo sapiens_hsa046102.36441962
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.23852333
9Caffeine metabolism_Homo sapiens_hsa002322.19419950
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14772832
11Nitrogen metabolism_Homo sapiens_hsa009102.12531002
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99038165
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.94273336
14Bile secretion_Homo sapiens_hsa049761.90137641
15Fatty acid metabolism_Homo sapiens_hsa012121.89280081
16Dilated cardiomyopathy_Homo sapiens_hsa054141.79684946
17Focal adhesion_Homo sapiens_hsa045101.78764348
18African trypanosomiasis_Homo sapiens_hsa051431.76270344
19Tryptophan metabolism_Homo sapiens_hsa003801.75086075
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.73816154
21Adherens junction_Homo sapiens_hsa045201.73244472
22ECM-receptor interaction_Homo sapiens_hsa045121.72237064
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.55368853
24Malaria_Homo sapiens_hsa051441.54525966
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52177398
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.49610518
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46879256
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45251205
29Prion diseases_Homo sapiens_hsa050201.44679367
30ABC transporters_Homo sapiens_hsa020101.41281976
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.25221972
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24834617
33Rap1 signaling pathway_Homo sapiens_hsa040151.22546154
34Insulin resistance_Homo sapiens_hsa049311.21761154
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18981498
36Platelet activation_Homo sapiens_hsa046111.18541612
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17779248
38beta-Alanine metabolism_Homo sapiens_hsa004101.14887800
39Bladder cancer_Homo sapiens_hsa052191.10528497
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10036471
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08820745
42Fatty acid elongation_Homo sapiens_hsa000621.04191833
43Peroxisome_Homo sapiens_hsa041461.01476657
44GnRH signaling pathway_Homo sapiens_hsa049120.99921886
45Other glycan degradation_Homo sapiens_hsa005110.98383835
46Notch signaling pathway_Homo sapiens_hsa043300.97602367
47Butanoate metabolism_Homo sapiens_hsa006500.97281516
48Staphylococcus aureus infection_Homo sapiens_hsa051500.95016295
49Vitamin digestion and absorption_Homo sapiens_hsa049770.94364438
50Ovarian steroidogenesis_Homo sapiens_hsa049130.92400222
51PI3K-Akt signaling pathway_Homo sapiens_hsa041510.92382649
52HIF-1 signaling pathway_Homo sapiens_hsa040660.91662869
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.91330084
54Small cell lung cancer_Homo sapiens_hsa052220.88659621
55Carbon metabolism_Homo sapiens_hsa012000.88615919
56Viral myocarditis_Homo sapiens_hsa054160.87506582
57Dorso-ventral axis formation_Homo sapiens_hsa043200.87221132
58Protein digestion and absorption_Homo sapiens_hsa049740.87128470
59Amoebiasis_Homo sapiens_hsa051460.87090477
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86607254
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85084999
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.84562806
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81371054
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80778257
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80039913
66Fat digestion and absorption_Homo sapiens_hsa049750.79145613
67Lysine degradation_Homo sapiens_hsa003100.78812913
68cAMP signaling pathway_Homo sapiens_hsa040240.78596354
69Pyruvate metabolism_Homo sapiens_hsa006200.78278535
70Endocytosis_Homo sapiens_hsa041440.77360949
71Estrogen signaling pathway_Homo sapiens_hsa049150.77348809
72Chronic myeloid leukemia_Homo sapiens_hsa052200.75139251
73Pancreatic cancer_Homo sapiens_hsa052120.74772755
74Oxytocin signaling pathway_Homo sapiens_hsa049210.74394702
75Phenylalanine metabolism_Homo sapiens_hsa003600.73937615
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72604966
77Starch and sucrose metabolism_Homo sapiens_hsa005000.71936884
78Tight junction_Homo sapiens_hsa045300.71907567
79Basal cell carcinoma_Homo sapiens_hsa052170.70642607
80Renin secretion_Homo sapiens_hsa049240.66938443
81Glucagon signaling pathway_Homo sapiens_hsa049220.66901933
82Proteoglycans in cancer_Homo sapiens_hsa052050.66571799
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65989552
84Toxoplasmosis_Homo sapiens_hsa051450.64664897
85Arginine and proline metabolism_Homo sapiens_hsa003300.64593548
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63223620
87MicroRNAs in cancer_Homo sapiens_hsa052060.62513977
88Melanogenesis_Homo sapiens_hsa049160.62446721
89Pathways in cancer_Homo sapiens_hsa052000.61692436
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60509673
91Ras signaling pathway_Homo sapiens_hsa040140.60446652
92Renin-angiotensin system_Homo sapiens_hsa046140.58204197
93VEGF signaling pathway_Homo sapiens_hsa043700.57965616
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57840530
95MAPK signaling pathway_Homo sapiens_hsa040100.57120926
96Insulin signaling pathway_Homo sapiens_hsa049100.56620620
97Salivary secretion_Homo sapiens_hsa049700.55540550
98Glioma_Homo sapiens_hsa052140.55007219
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53773301
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53144294
101TNF signaling pathway_Homo sapiens_hsa046680.52764907
102Salmonella infection_Homo sapiens_hsa051320.52050314
103AMPK signaling pathway_Homo sapiens_hsa041520.49657695
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.49620986
105Glycerolipid metabolism_Homo sapiens_hsa005610.49381650
106Hippo signaling pathway_Homo sapiens_hsa043900.49356841
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.48903952
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48073165
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47888769
110Thyroid cancer_Homo sapiens_hsa052160.47636787
111Folate biosynthesis_Homo sapiens_hsa007900.47602448
112Gap junction_Homo sapiens_hsa045400.46151427
113Long-term depression_Homo sapiens_hsa047300.46059710
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45784238
115Vitamin B6 metabolism_Homo sapiens_hsa007500.45726481
116Choline metabolism in cancer_Homo sapiens_hsa052310.45688501
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45016913
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44371823
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44270554
120Tyrosine metabolism_Homo sapiens_hsa003500.43940367
121Gastric acid secretion_Homo sapiens_hsa049710.43835019
122Renal cell carcinoma_Homo sapiens_hsa052110.43646446
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43272435
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.42071653
125Hedgehog signaling pathway_Homo sapiens_hsa043400.41929795
126Lysosome_Homo sapiens_hsa041420.41718658
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41453536
128Serotonergic synapse_Homo sapiens_hsa047260.40555124
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40226681
130Axon guidance_Homo sapiens_hsa043600.39820511
131Chemical carcinogenesis_Homo sapiens_hsa052040.39697439
132Pertussis_Homo sapiens_hsa051330.39353267
133Cardiac muscle contraction_Homo sapiens_hsa042600.39032279
134Hepatitis C_Homo sapiens_hsa051600.38584234
135Fatty acid biosynthesis_Homo sapiens_hsa000610.38567872
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38212469
137TGF-beta signaling pathway_Homo sapiens_hsa043500.37700486
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37648042
139Circadian rhythm_Homo sapiens_hsa047100.36646967
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36597675
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.36068435
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35975808
143Shigellosis_Homo sapiens_hsa051310.35103717

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