ROCK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)4.86608475
2detection of molecule of bacterial origin (GO:0032490)4.06311909
3cellular extravasation (GO:0045123)4.01441643
4phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.80870016
5meiotic chromosome segregation (GO:0045132)3.72002644
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65009064
7negative regulation of cell killing (GO:0031342)3.65009064
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.60115653
9positive regulation by organism of defense response of other organism involved in symbiotic interact3.60115653
10modulation by symbiont of host immune response (GO:0052553)3.60115653
11positive regulation by symbiont of host defense response (GO:0052509)3.60115653
12modulation by symbiont of host defense response (GO:0052031)3.60115653
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.60115653
14regulation of gamma-delta T cell activation (GO:0046643)3.56096281
15regulation of gamma-delta T cell differentiation (GO:0045586)3.50234085
16negative T cell selection (GO:0043383)3.45087736
17negative thymic T cell selection (GO:0045060)3.44408345
18B cell receptor signaling pathway (GO:0050853)3.44216046
19monoubiquitinated protein deubiquitination (GO:0035520)3.41732340
20histone H3-K4 trimethylation (GO:0080182)3.38690278
21kinetochore organization (GO:0051383)3.28925482
22negative regulation of T cell mediated immunity (GO:0002710)3.27134090
23centriole replication (GO:0007099)3.23727762
24establishment of protein localization to Golgi (GO:0072600)3.19482651
25positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.18001392
26mitotic sister chromatid cohesion (GO:0007064)3.17764465
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16927248
28neutrophil mediated immunity (GO:0002446)3.16121069
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.13233731
30positive regulation of mitotic sister chromatid separation (GO:1901970)3.10145096
31positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.10145096
32positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.10145096
33mitotic metaphase plate congression (GO:0007080)3.09350074
34microglial cell activation (GO:0001774)3.09092019
35antigen processing and presentation via MHC class Ib (GO:0002475)3.07008204
36regulation of RIG-I signaling pathway (GO:0039535)3.02904906
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.01533841
38response to host immune response (GO:0052572)3.01533841
39protein targeting to Golgi (GO:0000042)3.00961372
40metaphase plate congression (GO:0051310)2.98844479
41detection of external biotic stimulus (GO:0098581)2.98831397
42positive T cell selection (GO:0043368)2.97807500
43sister chromatid cohesion (GO:0007062)2.96497533
44activated T cell proliferation (GO:0050798)2.96482447
45nuclear pore complex assembly (GO:0051292)2.95405192
46peptidyl-lysine trimethylation (GO:0018023)2.93299428
47retrograde transport, vesicle recycling within Golgi (GO:0000301)2.91915204
48histone mRNA catabolic process (GO:0071044)2.91703836
49regulation of interferon-beta biosynthetic process (GO:0045357)2.90815033
50response to host (GO:0075136)2.90531971
51response to host defenses (GO:0052200)2.90531971
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90531971
53negative regulation of interleukin-12 production (GO:0032695)2.88738492
54macrophage activation involved in immune response (GO:0002281)2.86949545
55necroptotic process (GO:0070266)2.84651065
56regulation of B cell differentiation (GO:0045577)2.83532224
57histone H3-K9 demethylation (GO:0033169)2.83443042
58histone H3-K36 demethylation (GO:0070544)2.83060197
59response to interleukin-15 (GO:0070672)2.82680817
60hypotonic response (GO:0006971)2.81042356
61kinetochore assembly (GO:0051382)2.79772014
62positive regulation of defense response to virus by host (GO:0002230)2.79270001
63centriole assembly (GO:0098534)2.78555309
64detection of other organism (GO:0098543)2.77971116
65myeloid leukocyte mediated immunity (GO:0002444)2.77587010
66necrotic cell death (GO:0070265)2.76552141
67cellular response to ethanol (GO:0071361)2.76516151
68regulation of necroptotic process (GO:0060544)2.76179242
69establishment of chromosome localization (GO:0051303)2.75711907
70negative regulation of DNA-dependent DNA replication (GO:2000104)2.73492957
71cytoplasmic mRNA processing body assembly (GO:0033962)2.73355363
72T cell selection (GO:0045058)2.70570033
73attachment of spindle microtubules to kinetochore (GO:0008608)2.69291692
74detection of biotic stimulus (GO:0009595)2.69157031
75production of molecular mediator involved in inflammatory response (GO:0002532)2.68841871
76positive regulation of B cell differentiation (GO:0045579)2.68098859
77mitotic chromosome condensation (GO:0007076)2.67870449
78regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.66853274
79B cell proliferation (GO:0042100)2.66774642
80female gonad development (GO:0008585)2.66191377
81neutrophil activation involved in immune response (GO:0002283)2.63967341
82cellular response to gamma radiation (GO:0071480)2.63092305
83positive thymic T cell selection (GO:0045059)2.62231547
84regulation of protein polyubiquitination (GO:1902914)2.62075195
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.61204644
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.59573203
87N-terminal protein amino acid acetylation (GO:0006474)2.59563588
88regulation of tolerance induction (GO:0002643)2.57022881
89positive regulation of interleukin-17 production (GO:0032740)2.55819576
90phospholipid translocation (GO:0045332)2.55706769
91lipid translocation (GO:0034204)2.55706769
92negative regulation of lymphocyte mediated immunity (GO:0002707)2.55614424
93negative regulation of DNA repair (GO:0045738)2.55374698
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.54833979
95* regulation of establishment of cell polarity (GO:2000114)2.54745613
96pre-miRNA processing (GO:0031054)2.52454962
97macrophage activation (GO:0042116)2.52324085
98T cell proliferation (GO:0042098)2.52121327
99meiotic cell cycle (GO:0051321)2.51426015
100positive regulation of chromosome segregation (GO:0051984)2.50305834
101cellular response to interleukin-15 (GO:0071350)2.50213149
102positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.49696445
103positive regulation of tolerance induction (GO:0002645)2.49612476
104regulation of sister chromatid cohesion (GO:0007063)2.49586630
105response to muramyl dipeptide (GO:0032495)2.49303565
106regulation of RNA export from nucleus (GO:0046831)2.49020475
107growth hormone receptor signaling pathway (GO:0060396)2.48554201
108myeloid cell activation involved in immune response (GO:0002275)2.47911082
109histone lysine demethylation (GO:0070076)2.47318732
110pore complex assembly (GO:0046931)2.46742485
111histone demethylation (GO:0016577)2.44965544
112negative regulation of fibroblast apoptotic process (GO:2000270)2.44264319
113programmed necrotic cell death (GO:0097300)2.42573316
114regulation of fibroblast apoptotic process (GO:2000269)2.41274829
115DNA damage induced protein phosphorylation (GO:0006975)2.40608773
116hepatocyte apoptotic process (GO:0097284)2.39646375
117maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.39302489
118T cell lineage commitment (GO:0002360)2.36918364
119regulation of spindle organization (GO:0090224)2.36401018
120negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.35604657
121positive regulation of gamma-delta T cell activation (GO:0046645)2.34065914
122leukocyte aggregation (GO:0070486)2.30089509
123DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.29502628
124poly(A)+ mRNA export from nucleus (GO:0016973)2.28980574
125regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.28932206
126CENP-A containing nucleosome assembly (GO:0034080)2.28775429
127microtubule depolymerization (GO:0007019)2.26189529
128positive regulation of interferon-beta production (GO:0032728)2.25494956
129negative regulation of B cell proliferation (GO:0030889)2.24950637
130interferon-gamma production (GO:0032609)2.24889524
131radial glial cell differentiation (GO:0060019)2.24181705
132regulation of transcription from RNA polymerase I promoter (GO:0006356)2.24048666
133regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.22679332
134CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.21271013
135T-helper cell differentiation (GO:0042093)2.21271013
136tyrosine phosphorylation of STAT protein (GO:0007260)2.20749010
137positive regulation of interferon-alpha production (GO:0032727)2.20418847
138female gamete generation (GO:0007292)2.20253815
139neutrophil activation (GO:0042119)2.19930734
140response to peptidoglycan (GO:0032494)2.19669859
141nuclear pore organization (GO:0006999)2.15972912
142regulation of interferon-alpha production (GO:0032647)2.15688504
143definitive hemopoiesis (GO:0060216)2.15577255
144positive regulation of granulocyte differentiation (GO:0030854)2.15297015
145natural killer cell mediated immunity (GO:0002228)2.15106085
146natural killer cell mediated cytotoxicity (GO:0042267)2.15106085
147DNA damage response, signal transduction resulting in transcription (GO:0042772)2.15008322
148corticosteroid receptor signaling pathway (GO:0031958)2.11299259
149regulation of mitotic spindle organization (GO:0060236)2.11050061
150regulation of alpha-beta T cell proliferation (GO:0046640)2.10921368
151cellular response to growth hormone stimulus (GO:0071378)2.10201725
152positive regulation of macrophage differentiation (GO:0045651)2.09663699
153positive regulation of alpha-beta T cell proliferation (GO:0046641)2.08820015
154negative regulation of keratinocyte proliferation (GO:0010839)2.08425375
155chromatin remodeling at centromere (GO:0031055)2.08218241
156pericardium development (GO:0060039)2.08095912
157microtubule anchoring (GO:0034453)2.07676665
158regulation of mitotic spindle checkpoint (GO:1903504)2.06997433
159regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.06997433
160DNA synthesis involved in DNA repair (GO:0000731)2.06100663
161positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.05950244
162interkinetic nuclear migration (GO:0022027)2.05699227
163positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.05696853
164negative regulation of neurotransmitter secretion (GO:0046929)2.04759562
165granulocyte activation (GO:0036230)2.04659156
166histone monoubiquitination (GO:0010390)2.04344478
167histone H2A monoubiquitination (GO:0035518)2.04132394
168platelet-derived growth factor receptor signaling pathway (GO:0048008)2.03828766
169male meiosis I (GO:0007141)2.03705514
170protein localization to chromosome, centromeric region (GO:0071459)2.01586915
171regulation of retinoic acid receptor signaling pathway (GO:0048385)2.01155831
172protein K11-linked deubiquitination (GO:0035871)2.00998269
173replication fork processing (GO:0031297)2.00747825
174regulation of attachment of spindle microtubules to kinetochore (GO:0051988)1.99932968

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.26430950
2E2F7_22180533_ChIP-Seq_HELA_Human3.52942067
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.36880441
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.05184235
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.01884755
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.70430710
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.59112972
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54780066
9* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.49326245
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45691681
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.38712962
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.38547907
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.31321053
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.25492081
15PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97366165
16FOXM1_23109430_ChIP-Seq_U2OS_Human1.97226078
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.96321665
18* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95923232
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90897431
20IRF8_27001747_Chip-Seq_BMDM_Mouse1.82162092
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.81831918
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81065787
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78698782
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75521614
25* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.74491234
26GATA1_22025678_ChIP-Seq_K562_Human1.68227839
27RUNX_20019798_ChIP-Seq_JUKART_Human1.66182374
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.58088973
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56254253
30EWS_26573619_Chip-Seq_HEK293_Human1.50767934
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49912141
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49170169
33* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48961335
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48362346
35FUS_26573619_Chip-Seq_HEK293_Human1.48055452
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47476961
37CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.46321953
38* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44482428
39ELK1_19687146_ChIP-ChIP_HELA_Human1.44252935
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41813419
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40923015
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40478146
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.40246124
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40063484
45MYB_26560356_Chip-Seq_TH2_Human1.38111569
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.36537165
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34669008
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.33753511
49* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33730676
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32895972
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31203597
52SCL_19346495_ChIP-Seq_HPC-7_Human1.31057457
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30415898
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29740366
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29307494
56* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29010660
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28675492
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28443690
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28290367
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28057401
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27250079
62MYB_26560356_Chip-Seq_TH1_Human1.26824385
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26245561
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24293274
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.23717959
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20673828
67TAF15_26573619_Chip-Seq_HEK293_Human1.20324995
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20230306
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.19930828
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18146598
71TP53_16413492_ChIP-PET_HCT116_Human1.17911234
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.17252714
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17240957
74SPI1_23127762_ChIP-Seq_K562_Human1.17062945
75VDR_24787735_ChIP-Seq_THP-1_Human1.13817850
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13049198
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.12787098
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.12611611
79NMYC_18555785_Chip-Seq_ESCs_Mouse1.11460645
80SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11307985
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.11259042
82CJUN_26792858_Chip-Seq_BT549_Human1.11111008
83OCT4_18555785_Chip-Seq_ESCs_Mouse1.11107867
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.10970207
85P53_22387025_ChIP-Seq_ESCs_Mouse1.08212594
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08051817
87WT1_19549856_ChIP-ChIP_CCG9911_Human1.07944251
88PU_27001747_Chip-Seq_BMDM_Mouse1.07515368
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06920114
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06208681
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05929295
92ER_23166858_ChIP-Seq_MCF-7_Human1.05779920
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.03708701
94SPI1_23547873_ChIP-Seq_NB4_Human1.03030106
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.02881166
96CDX2_22108803_ChIP-Seq_LS180_Human1.02854843
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.02779987
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02759877
99GATA3_27048872_Chip-Seq_THYMUS_Human1.02636266
100HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02143527
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02002034
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01272958
103NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01272958
104P300_18555785_Chip-Seq_ESCs_Mouse1.01265632
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.00107697
106OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99854944
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99583367
108* STAT3_23295773_ChIP-Seq_U87_Human0.99158903
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98327367
110GATA3_26560356_Chip-Seq_TH2_Human0.98176190
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97601411
112ZFX_18555785_Chip-Seq_ESCs_Mouse0.97469365
113PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96521586
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96517190
115PRDM14_20953172_ChIP-Seq_ESCs_Human0.96301865
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95242724
117ARNT_22903824_ChIP-Seq_MCF-7_Human0.95089816
118VDR_24763502_ChIP-Seq_THP-1_Human0.94819559
119* P300_19829295_ChIP-Seq_ESCs_Human0.94577960
120* BRD4_25478319_ChIP-Seq_HGPS_Human0.94469117
121* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93957316
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93837885
123E2F1_21310950_ChIP-Seq_MCF-7_Human0.93791762
124TP63_23658742_ChIP-Seq_EP156T_Human0.92513835
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91280653
126AHR_22903824_ChIP-Seq_MCF-7_Human0.89884002
127SMRT_27268052_Chip-Seq_Bcells_Human0.89705847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia2.93334748
2MP0008057_abnormal_DNA_replication2.77319595
3MP0003950_abnormal_plasma_membrane2.54979532
4MP0002877_abnormal_melanocyte_morpholog2.50058611
5MP0001835_abnormal_antigen_presentation2.44842954
6MP0005671_abnormal_response_to2.23306300
7MP0002006_tumorigenesis2.20025827
8MP0003724_increased_susceptibility_to2.16398495
9MP0003763_abnormal_thymus_physiology2.15358861
10MP0010352_gastrointestinal_tract_polyps2.10631864
11MP0005408_hypopigmentation2.04432362
12MP0008877_abnormal_DNA_methylation1.96277867
13MP0002166_altered_tumor_susceptibility1.92640229
14MP0003787_abnormal_imprinting1.92467984
15MP0008007_abnormal_cellular_replicative1.89733152
16MP0005000_abnormal_immune_tolerance1.85000811
17MP0002396_abnormal_hematopoietic_system1.79934958
18MP0005387_immune_system_phenotype1.79550352
19MP0001790_abnormal_immune_system1.79550352
20MP0001800_abnormal_humoral_immune1.73921348
21MP0005310_abnormal_salivary_gland1.73418582
22MP0009785_altered_susceptibility_to1.72854351
23MP0000383_abnormal_hair_follicle1.66741832
24* MP0002452_abnormal_antigen_presenting1.66430072
25MP0006082_CNS_inflammation1.65158062
26MP0005451_abnormal_body_composition1.64284433
27MP0003077_abnormal_cell_cycle1.63795433
28MP0002148_abnormal_hypersensitivity_rea1.63109797
29MP0002723_abnormal_immune_serum1.58232029
30MP0003693_abnormal_embryo_hatching1.57273404
31MP0005174_abnormal_tail_pigmentation1.52397531
32MP0009333_abnormal_splenocyte_physiolog1.52148200
33* MP0002420_abnormal_adaptive_immunity1.51589343
34* MP0001819_abnormal_immune_cell1.50425665
35* MP0002419_abnormal_innate_immunity1.46009479
36MP0002405_respiratory_system_inflammati1.45463339
37MP0010094_abnormal_chromosome_stability1.43193816
38MP0003300_gastrointestinal_ulcer1.39936480
39MP0005409_darkened_coat_color1.39269940
40MP0003448_altered_tumor_morphology1.39190366
41MP0003136_yellow_coat_color1.36411702
42MP0005025_abnormal_response_to1.35884301
43MP0003828_pulmonary_edema1.34546569
44MP0002398_abnormal_bone_marrow1.33284175
45MP0010678_abnormal_skin_adnexa1.32288902
46MP0000566_synostosis1.32211698
47MP0003183_abnormal_peptide_metabolism1.31663945
48MP0005171_absent_coat_pigmentation1.30486728
49MP0009384_cardiac_valve_regurgitation1.30380207
50MP0004808_abnormal_hematopoietic_stem1.30248966
51* MP0004883_abnormal_blood_vessel1.27448502
52MP0000685_abnormal_immune_system1.27077867
53MP0000716_abnormal_immune_system1.25917580
54MP0004381_abnormal_hair_follicle1.25594291
55MP0000465_gastrointestinal_hemorrhage1.25197848
56MP0010307_abnormal_tumor_latency1.23344847
57MP0002277_abnormal_respiratory_mucosa1.22898448
58MP0003221_abnormal_cardiomyocyte_apopto1.21919289
59MP0009697_abnormal_copulation1.17690016
60MP0005075_abnormal_melanosome_morpholog1.16069749
61MP0008058_abnormal_DNA_repair1.15696155
62MP0010155_abnormal_intestine_physiology1.15412556
63MP0003937_abnormal_limbs/digits/tail_de1.13115397
64MP0003718_maternal_effect1.12917969
65MP0008260_abnormal_autophagy1.11946810
66MP0001545_abnormal_hematopoietic_system1.11433927
67MP0005397_hematopoietic_system_phenotyp1.11433927
68MP0001879_abnormal_lymphatic_vessel1.09909338
69MP0003172_abnormal_lysosome_physiology1.09143929
70MP0005076_abnormal_cell_differentiation1.08431496
71MP0000569_abnormal_digit_pigmentation1.08017542
72MP0003436_decreased_susceptibility_to1.07510823
73MP0001873_stomach_inflammation1.06096528
74* MP0001851_eye_inflammation1.05618674
75MP0002933_joint_inflammation1.05517484
76MP0000015_abnormal_ear_pigmentation1.04680966
77MP0003111_abnormal_nucleus_morphology1.03154453
78MP0000689_abnormal_spleen_morphology1.03066200
79MP0003303_peritoneal_inflammation1.02747734
80MP0003890_abnormal_embryonic-extraembry1.02369145
81MP0003656_abnormal_erythrocyte_physiolo1.02126417
82MP0000858_altered_metastatic_potential0.99962759
83MP0002254_reproductive_system_inflammat0.98234643
84MP0002722_abnormal_immune_system0.96865662
85MP0003566_abnormal_cell_adhesion0.96307872
86MP0001119_abnormal_female_reproductive0.95759474
87* MP0005164_abnormal_response_to0.95500851
88MP0000490_abnormal_crypts_of0.95189954
89MP0001845_abnormal_inflammatory_respons0.93723790
90MP0002429_abnormal_blood_cell0.93398558
91MP0002132_abnormal_respiratory_system0.93227248
92MP0003941_abnormal_skin_development0.92824096
93MP0010368_abnormal_lymphatic_system0.92172631
94MP0004084_abnormal_cardiac_muscle0.91994481
95MP0004484_altered_response_of0.91606103
96MP0000371_diluted_coat_color0.91331289
97MP0002138_abnormal_hepatobiliary_system0.90971761
98MP0000703_abnormal_thymus_morphology0.89951559
99MP0003091_abnormal_cell_migration0.89368994
100MP0005621_abnormal_cell_physiology0.89175382
101MP0000372_irregular_coat_pigmentation0.87796435
102MP0001346_abnormal_lacrimal_gland0.87143602
103MP0000627_abnormal_mammary_gland0.86794657
104MP0004947_skin_inflammation0.86564403
105MP0002998_abnormal_bone_remodeling0.86481895
106MP0000427_abnormal_hair_cycle0.86471872
107MP0009115_abnormal_fat_cell0.86252369
108MP0008995_early_reproductive_senescence0.85804666
109MP0003045_fibrosis0.85113726
110MP0002098_abnormal_vibrissa_morphology0.84592886
111MP0006292_abnormal_olfactory_placode0.83875978
112MP0003943_abnormal_hepatobiliary_system0.83123339
113MP0000920_abnormal_myelination0.80457403
114MP0001915_intracranial_hemorrhage0.79582414
115MP0000350_abnormal_cell_proliferation0.79410372
116MP0000432_abnormal_head_morphology0.79306470
117* MP0000767_abnormal_smooth_muscle0.79101375
118MP0005464_abnormal_platelet_physiology0.77512087
119MP0006054_spinal_hemorrhage0.76541778
120MP0003121_genomic_imprinting0.75058903
121MP0003453_abnormal_keratinocyte_physiol0.74757976
122MP0004264_abnormal_extraembryonic_tissu0.74697720
123MP0005395_other_phenotype0.74665646
124MP0001958_emphysema0.72687413
125MP0001533_abnormal_skeleton_physiology0.72626911
126MP0003866_abnormal_defecation0.72329359
127MP0001853_heart_inflammation0.72224868
128MP0002163_abnormal_gland_morphology0.71643403
129MP0002086_abnormal_extraembryonic_tissu0.71134964
130MP0002019_abnormal_tumor_incidence0.70206503
131MP0008004_abnormal_stomach_pH0.69346253
132MP0009764_decreased_sensitivity_to0.69256859
133MP0002060_abnormal_skin_morphology0.67378361
134MP0002928_abnormal_bile_duct0.66745830
135MP0003252_abnormal_bile_duct0.66500669
136MP0003191_abnormal_cellular_cholesterol0.65295384
137MP0001191_abnormal_skin_condition0.65170346

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)5.26919784
2Chromsome breakage (HP:0040012)4.23523183
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.87927233
4Papillary thyroid carcinoma (HP:0002895)3.59753667
5Acute myeloid leukemia (HP:0004808)3.26828799
6Retrobulbar optic neuritis (HP:0100654)3.13153395
7Optic neuritis (HP:0100653)3.13153395
8Abnormality of the fingertips (HP:0001211)3.08346647
9Abnormality of the prostate (HP:0008775)3.03633516
10Aortic aneurysm (HP:0004942)3.02873868
11Volvulus (HP:0002580)3.00362242
12Recurrent abscess formation (HP:0002722)2.86438803
13Capillary hemangiomas (HP:0005306)2.76162908
14Lip pit (HP:0100267)2.75165667
15Abnormality of chromosome stability (HP:0003220)2.74320203
16Ectopic kidney (HP:0000086)2.72814925
17Abnormality of B cell number (HP:0010975)2.69891972
18Subacute progressive viral hepatitis (HP:0006572)2.68861351
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.67200579
20Eczematoid dermatitis (HP:0000976)2.67015792
21B lymphocytopenia (HP:0010976)2.57569516
22Orchitis (HP:0100796)2.52257065
23Recurrent bacterial skin infections (HP:0005406)2.50621117
24Acute lymphatic leukemia (HP:0006721)2.48252663
25Thyroiditis (HP:0100646)2.38551182
26Abnormality of T cell number (HP:0011839)2.38058355
27Myositis (HP:0100614)2.37300061
28T lymphocytopenia (HP:0005403)2.37076563
29Narrow palate (HP:0000189)2.36758445
30Birth length less than 3rd percentile (HP:0003561)2.36139840
31Curly hair (HP:0002212)2.32739680
32Hypoplasia of the thymus (HP:0000778)2.31007484
33Prominent nose (HP:0000448)2.29560747
34Gingival bleeding (HP:0000225)2.26600798
35Gingivitis (HP:0000230)2.26254297
36Adrenal hypoplasia (HP:0000835)2.25765785
37Parakeratosis (HP:0001036)2.25307513
38Long eyelashes (HP:0000527)2.24635535
39Thoracolumbar scoliosis (HP:0002944)2.24415126
40Conjunctival telangiectasia (HP:0000524)2.23778315
41Prolonged bleeding time (HP:0003010)2.23552470
42Peritonitis (HP:0002586)2.23048451
43Stomach cancer (HP:0012126)2.22347345
44Panhypogammaglobulinemia (HP:0003139)2.22288591
45Thyroid carcinoma (HP:0002890)2.19600486
46Viral hepatitis (HP:0006562)2.19538767
47Abnormality of incisor morphology (HP:0011063)2.19444102
48Low anterior hairline (HP:0000294)2.19195822
49Vasculitis (HP:0002633)2.18991172
50Clubbing of toes (HP:0100760)2.16238323
51Recurrent fungal infections (HP:0002841)2.15904096
52Hematochezia (HP:0002573)2.15459480
53Recurrent pneumonia (HP:0006532)2.14425407
54Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.14209556
55Keratoconjunctivitis sicca (HP:0001097)2.12305285
56Abnormality of the vasculature of the conjunctiva (HP:0008054)2.12042603
57Overgrowth (HP:0001548)2.11745818
58Abnormality of the preputium (HP:0100587)2.11205986
59Recurrent bronchitis (HP:0002837)2.10387034
60Truncal obesity (HP:0001956)2.08368185
61Osteomyelitis (HP:0002754)2.06488241
62Papilledema (HP:0001085)2.04987478
63Leukocytosis (HP:0001974)2.03983309
64Syringomyelia (HP:0003396)2.03943431
65Spinal cord lesions (HP:0100561)2.03943431
66Abnormal platelet volume (HP:0011876)2.03100122
67Duplicated collecting system (HP:0000081)2.02282336
68Abnormality of the nasal septum (HP:0000419)2.02121768
69Aortic dissection (HP:0002647)2.01618294
70Recurrent viral infections (HP:0004429)2.01162173
71Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00653687
72Inflammation of the large intestine (HP:0002037)2.00566266
73Facial hemangioma (HP:0000329)2.00307572
74Chronic diarrhea (HP:0002028)2.00223558
75Osteolytic defects of the phalanges of the hand (HP:0009771)1.99685833
76Osteolytic defects of the hand bones (HP:0009699)1.99685833
77Myelodysplasia (HP:0002863)1.99651463
78Meckel diverticulum (HP:0002245)1.98243513
79Transitional cell carcinoma of the bladder (HP:0006740)1.98151360
80Eosinophilia (HP:0001880)1.97952164
81Keratoconjunctivitis (HP:0001096)1.97729130
82Abnormality of the renal collecting system (HP:0004742)1.97595699
83Aplasia/Hypoplasia of the uvula (HP:0010293)1.97569177
84Periodontitis (HP:0000704)1.96366136
85Bladder neoplasm (HP:0009725)1.96163425
86Bladder carcinoma (HP:0002862)1.96163425
87Resting tremor (HP:0002322)1.95923697
88Chest pain (HP:0100749)1.95902221
89Recurrent gram-negative bacterial infections (HP:0005420)1.94443471
90Fair hair (HP:0002286)1.93928338
91White forelock (HP:0002211)1.93325066
92Chronic obstructive pulmonary disease (HP:0006510)1.93310089
93Obstructive lung disease (HP:0006536)1.93310089
94Hemoptysis (HP:0002105)1.92624698
95Spontaneous hematomas (HP:0007420)1.92300682
96Abnormality of male internal genitalia (HP:0000022)1.90572125
97Increased mean platelet volume (HP:0011877)1.89841166
98Mediastinal lymphadenopathy (HP:0100721)1.87971196
99Epistaxis (HP:0000421)1.87366389
100Recurrent skin infections (HP:0001581)1.86011181
101Patchy hypopigmentation of hair (HP:0011365)1.84722417
102Pulmonary infiltrates (HP:0002113)1.84636189
103Facial diplegia (HP:0001349)1.84531459
104Arterial tortuosity (HP:0005116)1.84130085
105Severe combined immunodeficiency (HP:0004430)1.83960086
106Abnormality of the hepatic vasculature (HP:0006707)1.83936353
107Colitis (HP:0002583)1.83467343
108Chronic mucocutaneous candidiasis (HP:0002728)1.82969915
109Recurrent cutaneous fungal infections (HP:0011370)1.82969915
110Abnormality of eosinophils (HP:0001879)1.82033231
111Meningitis (HP:0001287)1.81994761
112Abnormality of the frontal sinuses (HP:0002687)1.81746596
113Dilatation of the ascending aorta (HP:0005111)1.81611624
114Gastrointestinal inflammation (HP:0004386)1.81550646
115Metaphyseal dysplasia (HP:0100255)1.81114392
116Cellulitis (HP:0100658)1.81033704
117Macroorchidism (HP:0000053)1.80785097
118Amaurosis fugax (HP:0100576)1.80573321
119Arterial thrombosis (HP:0004420)1.79723266
120Spondylolisthesis (HP:0003302)1.79412535
121Abnormality of the ileum (HP:0001549)1.77699672
122Autoimmune thrombocytopenia (HP:0001973)1.77530916
123Thick nail (HP:0001805)1.77178999
124IgA deficiency (HP:0002720)1.76631472
125IgG deficiency (HP:0004315)1.75574190
126Deep philtrum (HP:0002002)1.73377777
127Encephalitis (HP:0002383)1.72272635
128Autoimmune hemolytic anemia (HP:0001890)1.71890081
129Pancreatic fibrosis (HP:0100732)1.70905973
130Stomatitis (HP:0010280)1.70440871
131Lymphoma (HP:0002665)1.69416331
132Neoplasm of the tracheobronchial system (HP:0100552)1.69207075
133Gastrointestinal infarctions (HP:0005244)1.68680919
134Recurrent lower respiratory tract infections (HP:0002783)1.68518020
135Absent frontal sinuses (HP:0002688)1.65251669
136Ectropion (HP:0000656)1.64616494
137Stillbirth (HP:0003826)1.63059151
138Abnormality of macrophages (HP:0004311)1.62706430
139Granulocytopenia (HP:0001913)1.61985057
140Myocardial infarction (HP:0001658)1.61253002
141Abnormal delayed hypersensitivity skin test (HP:0002963)1.61008442
142Molar tooth sign on MRI (HP:0002419)1.60777055
143Abnormality of midbrain morphology (HP:0002418)1.60777055
144Cystic hygroma (HP:0000476)1.60255422
145Renal cortical cysts (HP:0000803)1.59851004
146Abnormal hair whorl (HP:0010721)1.58840923
147Blepharitis (HP:0000498)1.58553297
148Abnormality of T cells (HP:0002843)1.56144660
149IgM deficiency (HP:0002850)1.55934537
150Flat capital femoral epiphysis (HP:0003370)1.55558224

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.38228347
2NUAK13.07256983
3MAP3K142.53138129
4TAOK32.30521370
5RIPK42.25510648
6TXK2.17184034
7IRAK42.14473775
8STK38L2.14108827
9PLK42.10953404
10JAK31.99647913
11FRK1.97043544
12STK31.95960365
13PBK1.92965079
14PIK3CG1.80043975
15NLK1.77664212
16CDC71.77159349
17ZAK1.75606860
18IRAK31.75532842
19STK101.74587779
20MST41.73439844
21AKT31.63069913
22MAP3K131.62567748
23CDK121.61086510
24TRPM71.54478569
25STK391.48392464
26TEC1.46120468
27MKNK21.46111509
28NEK61.45808163
29STK41.38257806
30IKBKE1.37690051
31CDK91.36406100
32SGK21.35633436
33MELK1.33421015
34PRPF4B1.33294729
35TNIK1.32892944
36EPHB11.30611407
37FES1.26398343
38IRAK11.25972737
39DMPK1.25427191
40BMPR21.25087562
41MAP2K31.24753853
42NEK91.24566762
43ERBB41.23020284
44MAP3K101.21454319
45SYK1.21452756
46IKBKB1.19999013
47STK241.19561425
48BMPR1B1.17707107
49CHUK1.17548521
50BRSK21.16812774
51CAMK1G1.15865323
52SRPK11.15360339
53MARK31.12408957
54MUSK1.11501648
55MKNK11.09430995
56EPHA31.09428014
57ZAP701.09177287
58MAP3K21.08593595
59MAP4K11.06785733
60CHEK21.05754304
61SGK31.05709314
62MAP3K61.04949087
63PIM11.04725425
64BLK1.03833617
65GRK61.03763791
66FGFR31.03169279
67BCR1.03129977
68CLK11.01628602
69ITK0.99085782
70CDK30.97332522
71CAMK1D0.95089447
72FGR0.93934414
73PIK3CA0.93499301
74TYK20.91667206
75JAK10.90814716
76PDGFRB0.89932077
77HIPK20.87159433
78YES10.84929534
79PRKCQ0.83283095
80CSK0.82713416
81ABL10.81639240
82ATM0.80572732
83PKN10.80308093
84CSNK1A1L0.77955664
85RPS6KA50.76241888
86CDK60.75772253
87BRD40.74299239
88LCK0.73388399
89AURKB0.71560572
90PTK2B0.71514234
91SIK30.71490484
92CDK80.71163942
93CDK40.70222597
94EIF2AK20.70038089
95JAK20.69404630
96CSNK1G10.69044187
97MYLK0.67687810
98TTK0.67403979
99CSF1R0.67052607
100IRAK20.66984620
101FGFR20.66504021
102INSRR0.66056153
103KSR10.65365038
104VRK10.65272087
105BTK0.63755025
106CAMKK20.63316007
107PAK30.63212983
108EGFR0.61909531
109TAF10.61194225
110WNK10.59089257
111CHEK10.58843302
112MAP3K10.57622686
113OXSR10.56100089
114KIT0.56014668
115STK380.54961682
116MATK0.54054871
117ACVR1B0.54025763
118NEK20.53920053
119TGFBR20.50902701
120PLK30.50712873
121PRKAA20.48942472
122HCK0.48549577
123LATS20.47998091
124MAP3K70.46638154
125LYN0.46040537
126MAPK70.45116281
127PNCK0.43171116
128ATR0.42211966
129PLK10.41578035
130SGK2230.41259297
131SGK4940.41259297
132PLK20.40786166
133CSNK1G30.40124219
134MAP3K30.38957054
135SIK20.38818443
136RPS6KA40.38002167
137EIF2AK30.34994163
138ERBB30.34889545
139TBK10.34321559
140DYRK20.33987855

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.27331267
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.23335191
3Basal transcription factors_Homo sapiens_hsa030222.14244051
4Graft-versus-host disease_Homo sapiens_hsa053322.07054402
5Allograft rejection_Homo sapiens_hsa053301.92854662
6Fanconi anemia pathway_Homo sapiens_hsa034601.86752229
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.86375304
8Non-homologous end-joining_Homo sapiens_hsa034501.85146776
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79772917
10Measles_Homo sapiens_hsa051621.79193643
11Primary immunodeficiency_Homo sapiens_hsa053401.78115293
12Non-small cell lung cancer_Homo sapiens_hsa052231.76829424
13Cell cycle_Homo sapiens_hsa041101.75800674
14Leishmaniasis_Homo sapiens_hsa051401.72782524
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71063434
16Autoimmune thyroid disease_Homo sapiens_hsa053201.69616543
17Hematopoietic cell lineage_Homo sapiens_hsa046401.64174315
18Herpes simplex infection_Homo sapiens_hsa051681.62273369
19Malaria_Homo sapiens_hsa051441.61701715
20Homologous recombination_Homo sapiens_hsa034401.49286934
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.48654905
22RNA degradation_Homo sapiens_hsa030181.44532390
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43933911
24p53 signaling pathway_Homo sapiens_hsa041151.36054445
25Sphingolipid metabolism_Homo sapiens_hsa006001.34007882
26RNA polymerase_Homo sapiens_hsa030201.32886501
27Protein export_Homo sapiens_hsa030601.28162949
28Ether lipid metabolism_Homo sapiens_hsa005651.27464276
29Asthma_Homo sapiens_hsa053101.26838503
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25755285
31Osteoclast differentiation_Homo sapiens_hsa043801.25622768
32Endometrial cancer_Homo sapiens_hsa052131.25420572
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24029087
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23005207
35* MicroRNAs in cancer_Homo sapiens_hsa052061.22645889
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22464274
37Pancreatic cancer_Homo sapiens_hsa052121.20295156
38TNF signaling pathway_Homo sapiens_hsa046681.20036093
39Influenza A_Homo sapiens_hsa051641.17261541
40Toxoplasmosis_Homo sapiens_hsa051451.17067632
41Adherens junction_Homo sapiens_hsa045201.12007720
42T cell receptor signaling pathway_Homo sapiens_hsa046601.11954827
43Hepatitis B_Homo sapiens_hsa051611.08839781
44* TGF-beta signaling pathway_Homo sapiens_hsa043501.08478823
45Prostate cancer_Homo sapiens_hsa052151.07934865
46Antigen processing and presentation_Homo sapiens_hsa046121.04874967
47B cell receptor signaling pathway_Homo sapiens_hsa046621.04688454
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.01204925
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00855168
50Viral myocarditis_Homo sapiens_hsa054161.00671110
51Small cell lung cancer_Homo sapiens_hsa052220.98094828
52Rheumatoid arthritis_Homo sapiens_hsa053230.95966435
53* Leukocyte transendothelial migration_Homo sapiens_hsa046700.94742035
54Glioma_Homo sapiens_hsa052140.94278262
55Inositol phosphate metabolism_Homo sapiens_hsa005620.93000932
56Pertussis_Homo sapiens_hsa051330.92055875
57mTOR signaling pathway_Homo sapiens_hsa041500.91540273
58* Chemokine signaling pathway_Homo sapiens_hsa040620.90203077
59Dorso-ventral axis formation_Homo sapiens_hsa043200.89616631
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89261931
61Viral carcinogenesis_Homo sapiens_hsa052030.86327889
62Tuberculosis_Homo sapiens_hsa051520.86213363
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86159120
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84897920
65* Focal adhesion_Homo sapiens_hsa045100.84377684
66Steroid biosynthesis_Homo sapiens_hsa001000.83157606
67Type I diabetes mellitus_Homo sapiens_hsa049400.81882742
68Epstein-Barr virus infection_Homo sapiens_hsa051690.81161077
69Apoptosis_Homo sapiens_hsa042100.79415152
70Arachidonic acid metabolism_Homo sapiens_hsa005900.78910868
71VEGF signaling pathway_Homo sapiens_hsa043700.77709683
72Staphylococcus aureus infection_Homo sapiens_hsa051500.77414790
73* Proteoglycans in cancer_Homo sapiens_hsa052050.77015304
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76947982
75FoxO signaling pathway_Homo sapiens_hsa040680.76317680
76Hepatitis C_Homo sapiens_hsa051600.76262131
77Renal cell carcinoma_Homo sapiens_hsa052110.75604149
78Ovarian steroidogenesis_Homo sapiens_hsa049130.75503549
79Prolactin signaling pathway_Homo sapiens_hsa049170.73867362
80Melanoma_Homo sapiens_hsa052180.73501673
81ErbB signaling pathway_Homo sapiens_hsa040120.73226828
82mRNA surveillance pathway_Homo sapiens_hsa030150.72174254
83Legionellosis_Homo sapiens_hsa051340.71764168
84HTLV-I infection_Homo sapiens_hsa051660.71520898
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71514208
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70276861
87* Sphingolipid signaling pathway_Homo sapiens_hsa040710.69743867
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69669824
89Choline metabolism in cancer_Homo sapiens_hsa052310.69601279
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68380937
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67506697
92ECM-receptor interaction_Homo sapiens_hsa045120.67382269
93* Shigellosis_Homo sapiens_hsa051310.67243651
94MAPK signaling pathway_Homo sapiens_hsa040100.67097580
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66904079
96Chronic myeloid leukemia_Homo sapiens_hsa052200.66677981
97Amoebiasis_Homo sapiens_hsa051460.66518386
98* Platelet activation_Homo sapiens_hsa046110.66178733
99Linoleic acid metabolism_Homo sapiens_hsa005910.66010725
100* Salmonella infection_Homo sapiens_hsa051320.65623421
101African trypanosomiasis_Homo sapiens_hsa051430.65097633
102* Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63523662
103Insulin resistance_Homo sapiens_hsa049310.62687317
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.61189223
105Long-term potentiation_Homo sapiens_hsa047200.60747028
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60706171
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59972388
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59971047
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59526798
110GnRH signaling pathway_Homo sapiens_hsa049120.59306361
111Spliceosome_Homo sapiens_hsa030400.57742912
112* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57722102
113Notch signaling pathway_Homo sapiens_hsa043300.57332419
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57057634
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57044763
116* Pathways in cancer_Homo sapiens_hsa052000.56595796
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56291432
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55458180
119Phagosome_Homo sapiens_hsa041450.54896403
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54219692
121Colorectal cancer_Homo sapiens_hsa052100.53315716
122HIF-1 signaling pathway_Homo sapiens_hsa040660.53228161
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52881011
124Estrogen signaling pathway_Homo sapiens_hsa049150.52436727
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51855833
126Ras signaling pathway_Homo sapiens_hsa040140.50550485
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49874279
128Rap1 signaling pathway_Homo sapiens_hsa040150.48719600
129Acute myeloid leukemia_Homo sapiens_hsa052210.48527586
130Mismatch repair_Homo sapiens_hsa034300.48204846
131Thyroid cancer_Homo sapiens_hsa052160.48101694
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46925423
133RNA transport_Homo sapiens_hsa030130.46881891

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