ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	signal peptide processing (GO:0006465)	7.82853934
2	cilium or flagellum-dependent cell motility (GO:0001539)	7.72877264
3	tryptophan catabolic process (GO:0006569)	6.75610253
4	indole-containing compound catabolic process (GO:0042436)	6.75610253
5	indolalkylamine catabolic process (GO:0046218)	6.75610253
6	indolalkylamine metabolic process (GO:0006586)	6.50236396
7	kynurenine metabolic process (GO:0070189)	6.42327438
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	6.23303673
9	regulation of hippo signaling (GO:0035330)	5.78892278
10	tryptophan metabolic process (GO:0006568)	5.51446788
11	regulation of posttranscriptional gene silencing (GO:0060147)	5.50483180
12	regulation of gene silencing by miRNA (GO:0060964)	5.50483180
13	regulation of gene silencing by RNA (GO:0060966)	5.50483180
14	tachykinin receptor signaling pathway (GO:0007217)	5.25745470
15	UDP-N-acetylglucosamine metabolic process (GO:0006047)	4.81592621
16	indole-containing compound metabolic process (GO:0042430)	4.73511170
17	photoreceptor cell maintenance (GO:0045494)	4.64561005
18	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.59947505
19	respiratory tube development (GO:0030323)	4.54645310
20	monoubiquitinated protein deubiquitination (GO:0035520)	4.53987358
21	auditory receptor cell stereocilium organization (GO:0060088)	4.52903595
22	NAD biosynthetic process (GO:0009435)	4.48115767
23	benzene-containing compound metabolic process (GO:0042537)	4.47046903
24	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	4.46267223
25	behavioral response to ethanol (GO:0048149)	4.46042896
26	reflex (GO:0060004)	4.43802678
27	histone H4-K12 acetylation (GO:0043983)	4.40208085
28	detection of mechanical stimulus involved in sensory perception (GO:0050974)	4.27049187
29	serotonin metabolic process (GO:0042428)	4.15536228
30	detection of light stimulus involved in sensory perception (GO:0050962)	4.12051628
31	detection of light stimulus involved in visual perception (GO:0050908)	4.12051628
32	negative regulation of calcium ion transport into cytosol (GO:0010523)	4.10248623
33	protein K48-linked deubiquitination (GO:0071108)	4.08897951
34	cellular ketone body metabolic process (GO:0046950)	3.95357804
35	cellular biogenic amine catabolic process (GO:0042402)	3.87330468
36	amine catabolic process (GO:0009310)	3.87330468
37	detection of mechanical stimulus (GO:0050982)	3.77148283
38	flavonoid metabolic process (GO:0009812)	3.75767833
39	primary amino compound metabolic process (GO:1901160)	3.71889541
40	phospholipid translocation (GO:0045332)	3.68867572
41	lipid translocation (GO:0034204)	3.68867572
42	positive regulation of developmental pigmentation (GO:0048087)	3.67291551
43	righting reflex (GO:0060013)	3.66176950
44	regulation of pigment cell differentiation (GO:0050932)	3.64363462
45	thyroid hormone metabolic process (GO:0042403)	3.63872253
46	aromatic amino acid family metabolic process (GO:0009072)	3.63036843
47	neural tube formation (GO:0001841)	3.59571444
48	aromatic amino acid family catabolic process (GO:0009074)	3.56575497
49	regulation of acrosome reaction (GO:0060046)	3.55859756
50	behavioral response to nicotine (GO:0035095)	3.55418921
51	snRNA transcription (GO:0009301)	3.54266110
52	regulation of skeletal muscle contraction (GO:0014819)	3.53457531
53	response to misfolded protein (GO:0051788)	3.49527702
54	ketone body metabolic process (GO:1902224)	3.45975289
55	inner ear receptor stereocilium organization (GO:0060122)	3.43320843
56	dicarboxylic acid biosynthetic process (GO:0043650)	3.40784179
57	cellular response to sterol (GO:0036315)	3.38369828
58	negative regulation of keratinocyte proliferation (GO:0010839)	3.37789525
59	opioid receptor signaling pathway (GO:0038003)	3.36833852
60	nicotinamide nucleotide biosynthetic process (GO:0019359)	3.36790862
61	pyridine nucleotide biosynthetic process (GO:0019363)	3.36790862
62	xenobiotic catabolic process (GO:0042178)	3.32751301
63	negative regulation of complement activation (GO:0045916)	3.32531221
64	membrane depolarization during action potential (GO:0086010)	3.32434799
65	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.27105975
66	sphingoid metabolic process (GO:0046519)	3.25417865
67	cytokine biosynthetic process (GO:0042089)	3.21330829
68	regulation of establishment of cell polarity (GO:2000114)	3.21056660
69	sulfation (GO:0051923)	3.17991127
70	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.15662034
71	regulation of sarcomere organization (GO:0060297)	3.15103931
72	cilium movement (GO:0003341)	3.14062565
73	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.13595010
74	neuronal action potential (GO:0019228)	3.11667990
75	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.09984725
76	protein K63-linked deubiquitination (GO:0070536)	3.09845261
77	oxidative demethylation (GO:0070989)	3.09614748
78	positive regulation of cell cycle G2/M phase transition (GO:1902751)	3.07129955
79	positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)	3.07129955
80	response to nitrosative stress (GO:0051409)	3.06845667
81	inner cell mass cell proliferation (GO:0001833)	3.06148526
82	dicarboxylic acid catabolic process (GO:0043649)	3.04598907
83	positive regulation of vasculogenesis (GO:2001214)	2.96611574
84	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.96163511
85	regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)	2.95981529
86	negative regulation of cAMP-mediated signaling (GO:0043951)	2.93011128
87	negative regulation of protein activation cascade (GO:2000258)	2.88972478
88	establishment of protein localization to Golgi (GO:0072600)	2.88277267
89	gamma-aminobutyric acid transport (GO:0015812)	2.87228658
90	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	2.83975009
91	drug catabolic process (GO:0042737)	2.83439587
92	retinal cone cell development (GO:0046549)	2.81639649
93	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.78882550
94	cellular response to ethanol (GO:0071361)	2.78809060
95	regulation of vasculogenesis (GO:2001212)	2.76787182
96	one-carbon compound transport (GO:0019755)	2.75242810
97	skeletal muscle tissue regeneration (GO:0043403)	2.72084551
98	striated muscle atrophy (GO:0014891)	2.71806942
99	response to caffeine (GO:0031000)	2.70001059
100	L-methionine biosynthetic process (GO:0071265)	2.69826394

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.70601152
2	VDR_22108803_ChIP-Seq_LS180_Human	3.63351867
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.40267421
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.99838798
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.75852206
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.56054309
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.35980521
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.30852313
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.24992085
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.17700182
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.17374736
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.16389291
13	DROSHA_22980978_ChIP-Seq_HELA_Human	2.08510359
14	STAT3_23295773_ChIP-Seq_U87_Human	2.05256963
15	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.01477887
16	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.99957448
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98533649
18	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.93882904
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.92666807
20	P300_19829295_ChIP-Seq_ESCs_Human	1.88324151
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.86708354
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.81865372
23	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.80449373
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.78949832
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.77552139
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.76693372
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.73379089
28	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.69966833
29	TCF4_23295773_ChIP-Seq_U87_Human	1.67424561
30	AR_21572438_ChIP-Seq_LNCaP_Human	1.61509227
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.53959400
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.52674081
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52674081
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50444585
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.50444585
36	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.49960869
37	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49073645
38	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.48394552
39	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.47988890
40	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47841758
41	FUS_26573619_Chip-Seq_HEK293_Human	1.47505355
42	EWS_26573619_Chip-Seq_HEK293_Human	1.45129356
43	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.44021254
44	AR_25329375_ChIP-Seq_VCAP_Human	1.43191188
45	TCF4_22108803_ChIP-Seq_LS180_Human	1.42851770
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42255582
47	AHR_22903824_ChIP-Seq_MCF-7_Human	1.40368903
48	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.39025149
49	RXR_22108803_ChIP-Seq_LS180_Human	1.38683705
50	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.34961217
51	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.33275921
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32936115
53	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.32643817
54	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.31686991
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31233444
56	CDX2_22108803_ChIP-Seq_LS180_Human	1.29549070
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29407286
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23911117
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23911117
60	CJUN_26792858_Chip-Seq_BT549_Human	1.22738443
61	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.22440857
62	REST_21632747_ChIP-Seq_MESCs_Mouse	1.22147386
63	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.21889753
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21314074
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20659694
66	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.19891750
67	KDM2B_26808549_Chip-Seq_REH_Human	1.19536469
68	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19228524
69	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.16471130
70	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.13562799
71	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.12353736
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.12312294
73	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12036891
74	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.11738776
75	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11386568
76	AR_19668381_ChIP-Seq_PC3_Human	1.11241734
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10886134
78	TP53_18474530_ChIP-ChIP_U2OS_Human	1.10163598
79	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.08513680
80	TP53_16413492_ChIP-PET_HCT116_Human	1.07735475
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07540600
82	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07017299
83	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.04817230
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04301044
85	TP53_22573176_ChIP-Seq_HFKS_Human	1.04048803
86	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.03936184
87	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.03543557
88	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.02181644
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01956890
90	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.01689921
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.00266317
92	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99618330
93	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.99554329
94	TP63_23658742_ChIP-Seq_EP156T_Human	0.98504663
95	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.98473687
96	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.98473687
97	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.98448855
98	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.98405206
99	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.97364329
100	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.95286586

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	4.70189118
2	MP0008057_abnormal_DNA_replication	4.20035027
3	MP0003195_calcinosis	3.95813995
4	MP0001501_abnormal_sleep_pattern	3.82088295
5	MP0003950_abnormal_plasma_membrane	3.23836000
6	MP0003878_abnormal_ear_physiology	3.00410265
7	MP0005377_hearing/vestibular/ear_phenot	3.00410265
8	MP0001968_abnormal_touch/_nociception	2.94364782
9	MP0003879_abnormal_hair_cell	2.91982218
10	MP0001485_abnormal_pinna_reflex	2.87246244
11	MP0003646_muscle_fatigue	2.85794754
12	MP0005670_abnormal_white_adipose	2.85498908
13	MP0009046_muscle_twitch	2.82596320
14	MP0005551_abnormal_eye_electrophysiolog	2.61158695
15	MP0003045_fibrosis	2.56649745
16	MP0002736_abnormal_nociception_after	2.54161573
17	MP0000569_abnormal_digit_pigmentation	2.43002845
18	MP0004043_abnormal_pH_regulation	2.29906453
19	MP0006054_spinal_hemorrhage	2.25720141
20	MP0003136_yellow_coat_color	2.20634008
21	MP0009053_abnormal_anal_canal	1.99797321
22	MP0003252_abnormal_bile_duct	1.98166420
23	MP0010386_abnormal_urinary_bladder	1.98063505
24	MP0005410_abnormal_fertilization	1.91044549
25	MP0006276_abnormal_autonomic_nervous	1.90140770
26	MP0009745_abnormal_behavioral_response	1.75768431
27	MP0000538_abnormal_urinary_bladder	1.73313207
28	MP0005167_abnormal_blood-brain_barrier	1.55148010
29	MP0002168_other_aberrant_phenotype	1.51091583
30	MP0002733_abnormal_thermal_nociception	1.50992434
31	MP0002928_abnormal_bile_duct	1.50603950
32	MP0005310_abnormal_salivary_gland	1.49712989
33	MP0000427_abnormal_hair_cycle	1.44917973
34	MP0001664_abnormal_digestion	1.41179073
35	MP0000230_abnormal_systemic_arterial	1.39846906
36	MP0008961_abnormal_basal_metabolism	1.36314671
37	MP0005646_abnormal_pituitary_gland	1.35714557
38	MP0001970_abnormal_pain_threshold	1.35685406
39	MP0001486_abnormal_startle_reflex	1.32670628
40	MP0000383_abnormal_hair_follicle	1.31148032
41	MP0003633_abnormal_nervous_system	1.29703154
42	MP0002272_abnormal_nervous_system	1.29580108
43	MP0005645_abnormal_hypothalamus_physiol	1.28783643
44	MP0002064_seizures	1.27936872
45	MP0008872_abnormal_physiological_respon	1.26419834
46	MP0002735_abnormal_chemical_nociception	1.23119031
47	MP0002067_abnormal_sensory_capabilities	1.21576660
48	MP0002572_abnormal_emotion/affect_behav	1.20408920
49	MP0003183_abnormal_peptide_metabolism	1.20070577
50	MP0001963_abnormal_hearing_physiology	1.15605563
51	MP0002229_neurodegeneration	1.15255693
52	MP0002876_abnormal_thyroid_physiology	1.13808040
53	MP0005253_abnormal_eye_physiology	1.12714094
54	MP0004130_abnormal_muscle_cell	1.09907449
55	MP0001986_abnormal_taste_sensitivity	1.09548579
56	MP0005085_abnormal_gallbladder_physiolo	1.09003184
57	MP0005647_abnormal_sex_gland	1.07197646
58	MP0003635_abnormal_synaptic_transmissio	1.04047030
59	MP0005360_urolithiasis	1.02602817
60	MP0000371_diluted_coat_color	1.01710240
61	MP0005503_abnormal_tendon_morphology	1.00505850
62	MP0004036_abnormal_muscle_relaxation	1.00182686
63	MP0004147_increased_porphyrin_level	0.99944870
64	MP0003698_abnormal_male_reproductive	0.99885093
65	MP0002693_abnormal_pancreas_physiology	0.98279639
66	MP0004145_abnormal_muscle_electrophysio	0.97803500
67	MP0005266_abnormal_metabolism	0.97244932
68	MP0000026_abnormal_inner_ear	0.94022739
69	MP0005171_absent_coat_pigmentation	0.93716250
70	MP0004085_abnormal_heartbeat	0.91096216
71	MP0005595_abnormal_vascular_smooth	0.90756147
72	MP0001756_abnormal_urination	0.88289232
73	MP0005395_other_phenotype	0.88236252
74	MP0009764_decreased_sensitivity_to	0.87099247
75	MP0003638_abnormal_response/metabolism_	0.84455328
76	MP0004742_abnormal_vestibular_system	0.84293988
77	MP0000372_irregular_coat_pigmentation	0.84221921
78	MP0002090_abnormal_vision	0.83611241
79	MP0003631_nervous_system_phenotype	0.83180943
80	MP0006082_CNS_inflammation	0.82109655
81	MP0001661_extended_life_span	0.81581233
82	MP0001984_abnormal_olfaction	0.81541235
83	MP0000470_abnormal_stomach_morphology	0.81435764
84	MP0002102_abnormal_ear_morphology	0.80406338
85	MP0002557_abnormal_social/conspecific_i	0.78830328
86	MP0004215_abnormal_myocardial_fiber	0.77174782
87	MP0003959_abnormal_lean_body	0.76753376
88	MP0005275_abnormal_skin_tensile	0.74984636
89	MP0002938_white_spotting	0.73757800
90	MP0003119_abnormal_digestive_system	0.72433647
91	MP0001873_stomach_inflammation	0.69756156
92	MP0004142_abnormal_muscle_tone	0.69684518
93	MP0003868_abnormal_feces_composition	0.68604056
94	MP0000631_abnormal_neuroendocrine_gland	0.68420062
95	MP0003941_abnormal_skin_development	0.66983067
96	MP0005195_abnormal_posterior_eye	0.66285470
97	MP0005174_abnormal_tail_pigmentation	0.63844737
98	MP0002063_abnormal_learning/memory/cond	0.62561542
99	MP0001440_abnormal_grooming_behavior	0.60330133
100	MP0001765_abnormal_ion_homeostasis	0.60006718

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	5.90748838
2	Increased neuronal autofluorescent lipopigment (HP:0002074)	5.65986320
3	Genetic anticipation (HP:0003743)	5.37557634
4	Attenuation of retinal blood vessels (HP:0007843)	5.07649935
5	Ileus (HP:0002595)	5.00602564
6	Central scotoma (HP:0000603)	4.69176468
7	Pancreatic cysts (HP:0001737)	4.68766857
8	Increased cerebral lipofuscin (HP:0011813)	4.65895125
9	Congenital sensorineural hearing impairment (HP:0008527)	4.62314712
10	Gaze-evoked nystagmus (HP:0000640)	4.62159120
11	Clumsiness (HP:0002312)	4.49785190
12	Progressive cerebellar ataxia (HP:0002073)	4.35529578
13	Bony spicule pigmentary retinopathy (HP:0007737)	4.31250616
14	Dysmetric saccades (HP:0000641)	3.91055796
15	Cystic liver disease (HP:0006706)	3.62201516
16	True hermaphroditism (HP:0010459)	3.47240541
17	Pancreatic fibrosis (HP:0100732)	3.43226749
18	Abnormal ciliary motility (HP:0012262)	3.40039751
19	Facial diplegia (HP:0001349)	3.33975952
20	Congenital stationary night blindness (HP:0007642)	3.33596711
21	Scotoma (HP:0000575)	3.29153099
22	Decreased circulating renin level (HP:0003351)	3.24416495
23	Abnormality of binocular vision (HP:0011514)	3.22414809
24	Diplopia (HP:0000651)	3.22414809
25	Increased corneal curvature (HP:0100692)	3.18904190
26	Keratoconus (HP:0000563)	3.18904190
27	Abolished electroretinogram (ERG) (HP:0000550)	3.07720786
28	Abnormality of the renal cortex (HP:0011035)	3.03149871
29	Hyperventilation (HP:0002883)	2.95516319
30	Constricted visual fields (HP:0001133)	2.89390629
31	Focal seizures (HP:0007359)	2.87427506
32	Facial shape deformation (HP:0011334)	2.75999412
33	Potter facies (HP:0002009)	2.75999412
34	Protruding tongue (HP:0010808)	2.74202394
35	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.71740361
36	Abnormal respiratory motile cilium physiology (HP:0012261)	2.70591074
37	Preaxial foot polydactyly (HP:0001841)	2.69454508
38	Chronic hepatic failure (HP:0100626)	2.60984076
39	Enlarged kidneys (HP:0000105)	2.57575599
40	Abnormality of the renal medulla (HP:0100957)	2.52178593
41	Large for gestational age (HP:0001520)	2.51769238
42	Abnormal drinking behavior (HP:0030082)	2.50454025
43	Polydipsia (HP:0001959)	2.50454025
44	Thyroid-stimulating hormone excess (HP:0002925)	2.48070709
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.46651016
46	Abnormality of alanine metabolism (HP:0010916)	2.46651016
47	Hyperalaninemia (HP:0003348)	2.46651016
48	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.44543593
49	Absent/shortened dynein arms (HP:0200106)	2.44543593
50	Congenital hepatic fibrosis (HP:0002612)	2.43088139
51	Dialeptic seizures (HP:0011146)	2.43075883
52	Febrile seizures (HP:0002373)	2.42792420
53	Tubulointerstitial fibrosis (HP:0005576)	2.39542594
54	Absent speech (HP:0001344)	2.38281132
55	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.33941923
56	Sclerocornea (HP:0000647)	2.32082181
57	Absence seizures (HP:0002121)	2.30582794
58	Prostate neoplasm (HP:0100787)	2.29703580
59	Cerebellar dysplasia (HP:0007033)	2.29624436
60	Abnormality of macular pigmentation (HP:0008002)	2.27888478
61	Furrowed tongue (HP:0000221)	2.26523001
62	Fair hair (HP:0002286)	2.26433208
63	Medial flaring of the eyebrow (HP:0010747)	2.24815217
64	Progressive visual loss (HP:0000529)	2.23335487
65	Hypothermia (HP:0002045)	2.21336622
66	Difficulty walking (HP:0002355)	2.20331226
67	Abnormality of midbrain morphology (HP:0002418)	2.19968417
68	Molar tooth sign on MRI (HP:0002419)	2.19968417
69	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.15287160
70	Nephronophthisis (HP:0000090)	2.11583984
71	Tubular atrophy (HP:0000092)	2.10402313
72	Type II lissencephaly (HP:0007260)	2.08875642
73	Tubulointerstitial abnormality (HP:0001969)	2.07425842
74	Hydroxyprolinuria (HP:0003080)	2.04921012
75	Abnormality of proline metabolism (HP:0010907)	2.04921012
76	Portal hypertension (HP:0001409)	2.01562205
77	Retinitis pigmentosa (HP:0000510)	2.01454431
78	Urinary bladder sphincter dysfunction (HP:0002839)	2.01238076
79	Hypoplastic ischia (HP:0003175)	1.99708834
80	Proximal tubulopathy (HP:0000114)	1.99098426
81	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.97979863
82	Abnormality of the ischium (HP:0003174)	1.97465085
83	Polyuria (HP:0000103)	1.96571320
84	Poikiloderma (HP:0001029)	1.96002252
85	Decreased central vision (HP:0007663)	1.92381976
86	Postural instability (HP:0002172)	1.91906028
87	Spastic paraplegia (HP:0001258)	1.91048612
88	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.89283109
89	Abnormality of renin-angiotensin system (HP:0000847)	1.88631407
90	Impaired smooth pursuit (HP:0007772)	1.87533349
91	Severe visual impairment (HP:0001141)	1.86351908
92	Abnormal rod and cone electroretinograms (HP:0008323)	1.86149312
93	Abnormality of the hepatic vasculature (HP:0006707)	1.86013770
94	Inability to walk (HP:0002540)	1.84785150
95	Congenital primary aphakia (HP:0007707)	1.84291072
96	Gait imbalance (HP:0002141)	1.84028363
97	Focal motor seizures (HP:0011153)	1.82835397
98	Small hand (HP:0200055)	1.80854796
99	Hyperkalemia (HP:0002153)	1.80487663
100	Opisthotonus (HP:0002179)	1.77185655

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	3.75677978
2	ACVR1B	2.80854823
3	BMPR1B	2.80753749
4	PIK3CG	2.77678623
5	INSRR	2.34775497
6	FRK	12.3801447
7	NTRK3	1.95566994
8	OXSR1	1.72846042
9	STK38L	1.71904703
10	TAOK3	1.71292623
11	ADRBK1	1.61016966
12	TIE1	1.56457430
13	GRK1	1.53685291
14	PINK1	1.46875298
15	ZAK	1.40829023
16	TNK2	1.33491243
17	STK39	1.29781408
18	TGFBR1	1.20749537
19	TEC	1.20189965
20	DAPK2	1.19347205
21	MKNK2	1.12236903
22	FER	1.11637872
23	CDK19	1.07831613
24	KDR	1.00572415
25	WNK3	0.99310843
26	STK38	0.98632459
27	LATS1	0.96984777
28	PRKCG	0.93976334
29	MAP3K7	0.91444817
30	STK3	0.89525622
31	PTK2B	0.84292538
32	ITK	0.83706816
33	PRKCE	0.78243436
34	TRPM7	0.76769367
35	MYLK	0.76709796
36	PRKAA2	0.76395884
37	NUAK1	0.69642671
38	PIK3CA	0.69375747
39	MELK	0.67771049
40	KIT	0.66471321
41	TXK	0.66172517
42	CASK	0.64087652
43	CAMK2A	0.63661026
44	MAPKAPK3	0.58264087
45	TLK1	0.56612276
46	MAPK13	0.56076334
47	WNK4	0.54177844
48	NEK2	0.53952200
49	MARK3	0.50412227
50	MUSK	0.49803204
51	SGK2	0.49491224
52	MAP3K4	0.49097578
53	BTK	0.47382416
54	MAPK15	0.46586867
55	MAPKAPK5	0.46417954
56	IRAK1	0.45747242
57	CHUK	0.44967337
58	IKBKB	0.44684518
59	PRKG2	0.43654507
60	PRKACB	0.40846982
61	OBSCN	0.40426785
62	CDK3	0.39155247
63	CAMK1	0.38760990
64	DDR2	0.38505043
65	PRKAA1	0.38384666
66	MAPK11	0.38275534
67	MKNK1	0.36819974
68	NLK	0.35302862
69	PDK1	0.35252447
70	PKN1	0.34472765
71	SYK	0.33487100
72	AKT3	0.32401351
73	PRKCB	0.32366852
74	PRKCH	0.31415320
75	CHEK2	0.31342085
76	MAP2K1	0.31035408
77	PRKCA	0.30659730
78	RPS6KA6	0.30446090
79	GRK7	0.29554639
80	MAP2K6	0.29464952
81	FES	0.29460741
82	PRKACA	0.29241598
83	SGK223	0.26427470
84	SGK494	0.26427470
85	RPS6KA5	0.26190617
86	BLK	0.25013872
87	MAP4K2	0.24828303
88	PRKCQ	0.23251961
89	HCK	0.22305901
90	GRK5	0.21721516
91	IGF1R	0.21170095
92	LCK	0.20393350
93	MAP3K9	0.20286676
94	RPS6KA3	0.20119030
95	EIF2AK3	0.19081366
96	PRKG1	0.18279661
97	MAPK7	0.17292086
98	CSNK1D	0.17238718
99	AKT1	0.17232559
100	LYN	0.17217471

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	ABC transporters_Homo sapiens_hsa02010	3.53178283
2	Tryptophan metabolism_Homo sapiens_hsa00380	3.21397323
3	Butanoate metabolism_Homo sapiens_hsa00650	2.99324677
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.54521397
5	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.34690487
6	Nicotine addiction_Homo sapiens_hsa05033	2.32436990
7	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.30476871
8	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.21798818
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.07097378
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.05801837
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.03236399
12	Phototransduction_Homo sapiens_hsa04744	2.01460039
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.95204682
14	Histidine metabolism_Homo sapiens_hsa00340	1.85399718
15	Morphine addiction_Homo sapiens_hsa05032	1.85142027
16	Homologous recombination_Homo sapiens_hsa03440	1.74996372
17	Chemical carcinogenesis_Homo sapiens_hsa05204	1.74519588
18	Retinol metabolism_Homo sapiens_hsa00830	1.72850258
19	Olfactory transduction_Homo sapiens_hsa04740	1.72785268
20	Glycerolipid metabolism_Homo sapiens_hsa00561	1.67176372
21	Salivary secretion_Homo sapiens_hsa04970	1.59924490
22	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.59415320
23	Taste transduction_Homo sapiens_hsa04742	1.59327201
24	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.57995982
25	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.57749448
26	Circadian entrainment_Homo sapiens_hsa04713	1.49168850
27	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.47818825
28	Calcium signaling pathway_Homo sapiens_hsa04020	1.42568913
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.39581743
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.35683609
31	Serotonergic synapse_Homo sapiens_hsa04726	1.30858365
32	Glutamatergic synapse_Homo sapiens_hsa04724	1.29288856
33	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.26861751
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.26136886
35	GABAergic synapse_Homo sapiens_hsa04727	1.17168851
36	Pancreatic secretion_Homo sapiens_hsa04972	1.13389966
37	Graft-versus-host disease_Homo sapiens_hsa05332	1.13310641
38	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.12311294
39	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.10117119
40	Sphingolipid metabolism_Homo sapiens_hsa00600	1.05941586
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.04225397
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.03823897
43	Gastric acid secretion_Homo sapiens_hsa04971	1.02348924
44	Selenocompound metabolism_Homo sapiens_hsa00450	1.01434553
45	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.01404628
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.98262640
47	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.95069557
48	Protein digestion and absorption_Homo sapiens_hsa04974	0.94878287
49	Fatty acid degradation_Homo sapiens_hsa00071	0.89314995
50	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.88114607
51	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.86132340
52	Sulfur relay system_Homo sapiens_hsa04122	0.85934160
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.84152909
54	Insulin secretion_Homo sapiens_hsa04911	0.83441268
55	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.81674929
56	Renin secretion_Homo sapiens_hsa04924	0.81015549
57	Platelet activation_Homo sapiens_hsa04611	0.79356308
58	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.79045720
59	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.78351145
60	ECM-receptor interaction_Homo sapiens_hsa04512	0.77488707
61	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.76966813
62	Bile secretion_Homo sapiens_hsa04976	0.76798806
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.75603005
64	Cholinergic synapse_Homo sapiens_hsa04725	0.74904215
65	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.72882533
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64182023
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64070897
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.62789242
69	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.59593882
70	One carbon pool by folate_Homo sapiens_hsa00670	0.59395941
71	Asthma_Homo sapiens_hsa05310	0.58227889
72	Long-term depression_Homo sapiens_hsa04730	0.57887640
73	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.55561731
74	cAMP signaling pathway_Homo sapiens_hsa04024	0.55153583
75	Complement and coagulation cascades_Homo sapiens_hsa04610	0.54369043
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.54270635
77	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.52974520
78	Lysine degradation_Homo sapiens_hsa00310	0.52862513
79	Propanoate metabolism_Homo sapiens_hsa00640	0.52337486
80	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.49902596
81	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.49164295
82	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.44086081
83	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.43435219
84	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.43257266
85	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.42003179
86	Fat digestion and absorption_Homo sapiens_hsa04975	0.41732381
87	Ras signaling pathway_Homo sapiens_hsa04014	0.41089267
88	Type II diabetes mellitus_Homo sapiens_hsa04930	0.40545823
89	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.40514708
90	Glutathione metabolism_Homo sapiens_hsa00480	0.40364258
91	Mineral absorption_Homo sapiens_hsa04978	0.39797750
92	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.39245275
93	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.38856022
94	PPAR signaling pathway_Homo sapiens_hsa03320	0.37998329
95	Estrogen signaling pathway_Homo sapiens_hsa04915	0.37499077
96	Fanconi anemia pathway_Homo sapiens_hsa03460	0.37021038
97	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.36749904
98	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.36104799
99	Purine metabolism_Homo sapiens_hsa00230	0.35756122
100	Allograft rejection_Homo sapiens_hsa05330	0.35483727

ROCK1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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