ROCK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)3.73793402
2plasma membrane repair (GO:0001778)3.49820599
3locomotory exploration behavior (GO:0035641)3.47381805
4very-low-density lipoprotein particle assembly (GO:0034379)3.43835509
5embryonic retina morphogenesis in camera-type eye (GO:0060059)3.33727828
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.31836705
7negative regulation of protein activation cascade (GO:2000258)3.30257080
8negative regulation of fibrinolysis (GO:0051918)3.29874529
9positive regulation of fibroblast migration (GO:0010763)3.23408342
10synaptic vesicle docking involved in exocytosis (GO:0016081)3.19453446
11vocalization behavior (GO:0071625)3.17771334
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.16611562
13negative regulation of complement activation (GO:0045916)3.13620529
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.11025242
15synaptic vesicle maturation (GO:0016188)3.02483710
16negative regulation of fatty acid transport (GO:2000192)2.99492564
17regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.96765298
18mitotic sister chromatid cohesion (GO:0007064)2.96466824
19chondrocyte proliferation (GO:0035988)2.95866429
20ionotropic glutamate receptor signaling pathway (GO:0035235)2.95609557
21establishment of nucleus localization (GO:0040023)2.91142504
22regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.91055738
23glutamate secretion (GO:0014047)2.90320300
24nuclear pore organization (GO:0006999)2.89401653
25regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.89312019
26regulation of complement activation (GO:0030449)2.88416045
27regulation of protein activation cascade (GO:2000257)2.85661989
28positive regulation of cardiac muscle cell differentiation (GO:2000727)2.81991961
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.80276848
30insulin-like growth factor receptor signaling pathway (GO:0048009)2.76194552
31regulation of dendritic spine morphogenesis (GO:0061001)2.75982741
32desmosome organization (GO:0002934)2.75155293
33COPII vesicle coating (GO:0048208)2.74835485
34notochord development (GO:0030903)2.73791386
35regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.73128053
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.72188871
37regulation of long-term neuronal synaptic plasticity (GO:0048169)2.71692581
38response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.71061501
39regulation of glutamate receptor signaling pathway (GO:1900449)2.69048272
40positive regulation of dendritic spine morphogenesis (GO:0061003)2.67231137
41glutamate receptor signaling pathway (GO:0007215)2.66698944
42skin morphogenesis (GO:0043589)2.65967110
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.64623617
44synaptic vesicle exocytosis (GO:0016079)2.64314023
45plasma lipoprotein particle assembly (GO:0034377)2.63711104
46sequestering of extracellular ligand from receptor (GO:0035581)2.63575077
47response to muscle activity (GO:0014850)2.63295134
48cytoskeletal anchoring at plasma membrane (GO:0007016)2.63237116
49regulation of cell communication by electrical coupling (GO:0010649)2.62883183
50regulation of fibrinolysis (GO:0051917)2.62808070
51protein-lipid complex assembly (GO:0065005)2.60591982
52cell adhesion mediated by integrin (GO:0033627)2.60144178
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.59817947
54hypotonic response (GO:0006971)2.58300222
55regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.56062310
56regulation of apoptotic cell clearance (GO:2000425)2.55374109
57peptidyl-glutamic acid carboxylation (GO:0017187)2.55326270
58protein carboxylation (GO:0018214)2.55326270
59axon extension involved in axon guidance (GO:0048846)2.54380141
60neuron projection extension involved in neuron projection guidance (GO:1902284)2.54380141
61paraxial mesoderm development (GO:0048339)2.53834232
62regulation of non-canonical Wnt signaling pathway (GO:2000050)2.53569801
63NLS-bearing protein import into nucleus (GO:0006607)2.53240096
64regulation of RNA export from nucleus (GO:0046831)2.53138706
65positive regulation of cardiac muscle hypertrophy (GO:0010613)2.52466776
66positive regulation of muscle hypertrophy (GO:0014742)2.52466776
67cell-substrate junction assembly (GO:0007044)2.51976215
68protein targeting to Golgi (GO:0000042)2.51642943
69positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.51162696
70collagen fibril organization (GO:0030199)2.50387334
71hemidesmosome assembly (GO:0031581)2.49410661
72layer formation in cerebral cortex (GO:0021819)2.48439477
73long-term synaptic potentiation (GO:0060291)2.47519954
74cellular potassium ion homeostasis (GO:0030007)2.47117782
75stress fiber assembly (GO:0043149)2.47067269
76retrograde transport, vesicle recycling within Golgi (GO:0000301)2.46981312
77intestinal absorption (GO:0050892)2.46856172
78regulation of excitatory postsynaptic membrane potential (GO:0060079)2.46095123
79hepatocyte differentiation (GO:0070365)2.45318615
80embryonic foregut morphogenesis (GO:0048617)2.42760790
81regulation of synaptic vesicle exocytosis (GO:2000300)2.41910917
82establishment of protein localization to Golgi (GO:0072600)2.41886205
83gamma-aminobutyric acid signaling pathway (GO:0007214)2.40763167
84regulation of dendritic spine development (GO:0060998)2.40414224
85activation of protein kinase A activity (GO:0034199)2.39705739
86cell communication by electrical coupling (GO:0010644)2.39639081
87neuronal action potential propagation (GO:0019227)2.39024736
88regulation of plasminogen activation (GO:0010755)2.38582163
89exploration behavior (GO:0035640)2.38334394
90axonal fasciculation (GO:0007413)2.37680673
91vesicle transport along microtubule (GO:0047496)2.37565667
92inner ear receptor cell development (GO:0060119)2.37057352
93dendritic spine morphogenesis (GO:0060997)2.36628796
94regulation of postsynaptic membrane potential (GO:0060078)2.36474882
95substrate adhesion-dependent cell spreading (GO:0034446)2.35708622
96pore complex assembly (GO:0046931)2.35592467
97positive regulation of extracellular matrix organization (GO:1903055)2.34721699
98regulation of synapse structural plasticity (GO:0051823)2.33969753
99mitotic cytokinesis (GO:0000281)2.33782820
100regulation of clathrin-mediated endocytosis (GO:2000369)2.33051937
101negative regulation of sodium ion transport (GO:0010766)2.32592524
102regulation of calcium ion transmembrane transport (GO:1903169)2.32362427
103regulation of calcium ion transmembrane transporter activity (GO:1901019)2.32362427
104basement membrane organization (GO:0071711)2.32358156
105relaxation of cardiac muscle (GO:0055119)2.31777516
106intestinal cholesterol absorption (GO:0030299)2.31495443
107regulation of neuronal synaptic plasticity (GO:0048168)2.31434151
108negative regulation of synaptic transmission, GABAergic (GO:0032229)2.31417498
109positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.30972249
110cytoskeleton-dependent cytokinesis (GO:0061640)2.30703519
111mesodermal cell differentiation (GO:0048333)2.30036603
112protein localization to endosome (GO:0036010)2.29882436
113long-term memory (GO:0007616)2.29598023
114protein localization to synapse (GO:0035418)2.29522193
115regulation of mitotic spindle organization (GO:0060236)2.29143721
116cell-substrate adherens junction assembly (GO:0007045)2.28447587
117focal adhesion assembly (GO:0048041)2.28447587
118low-density lipoprotein particle remodeling (GO:0034374)2.28326919
119proline transport (GO:0015824)2.28235944
120negative regulation of DNA repair (GO:0045738)2.28090946
121pericardium development (GO:0060039)2.27208810
122actin-mediated cell contraction (GO:0070252)2.27096550
123long term synaptic depression (GO:0060292)2.26719025
124nucleus localization (GO:0051647)2.26542536
125endocardial cushion development (GO:0003197)2.26320721
126neuron-neuron synaptic transmission (GO:0007270)2.25804180
127morphogenesis of an epithelial sheet (GO:0002011)2.25693917
128lymphangiogenesis (GO:0001946)2.25349757
129glomerular visceral epithelial cell development (GO:0072015)2.24386132
130sodium ion export (GO:0071436)2.23206497
131regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.23017759
132cardiac myofibril assembly (GO:0055003)2.22587460
133regulation of voltage-gated calcium channel activity (GO:1901385)2.22069827
134regulation of bile acid biosynthetic process (GO:0070857)2.21782460
135synaptic transmission, glutamatergic (GO:0035249)2.21638892
136dendrite morphogenesis (GO:0048813)2.21507151
137axon extension (GO:0048675)2.21356820
138negative regulation of keratinocyte proliferation (GO:0010839)2.21047627
139embryonic process involved in female pregnancy (GO:0060136)2.20704611
140protein localization to cell surface (GO:0034394)2.20643914
141interkinetic nuclear migration (GO:0022027)2.20451683
142regulation of synaptic plasticity (GO:0048167)2.20194906
143neuron recognition (GO:0008038)2.20014418
144bundle of His cell to Purkinje myocyte communication (GO:0086069)2.19754298
145anterior/posterior axis specification, embryo (GO:0008595)2.18562562
146mesenchymal-epithelial cell signaling (GO:0060638)2.17704557
147negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.17619743
148regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.17438539
149regulation of nucleobase-containing compound transport (GO:0032239)2.17184283
150embryonic viscerocranium morphogenesis (GO:0048703)2.14299971
151midgut development (GO:0007494)2.13870014
152cerebellar Purkinje cell differentiation (GO:0021702)2.13625659
153blood coagulation, intrinsic pathway (GO:0007597)2.13350915
154negative regulation of protein localization to cell surface (GO:2000009)2.12788418
155cytoplasmic mRNA processing body assembly (GO:0033962)2.12500157
156retina vasculature morphogenesis in camera-type eye (GO:0061299)2.12481229
157cell migration involved in sprouting angiogenesis (GO:0002042)2.11634267
158detection of calcium ion (GO:0005513)2.11488982
159regulation of tight junction assembly (GO:2000810)2.11456176
160regulation of transforming growth factor beta2 production (GO:0032909)2.11414175
161negative regulation of potassium ion transmembrane transport (GO:1901380)2.11277831
162hippo signaling (GO:0035329)2.10632268
163adherens junction assembly (GO:0034333)2.10312392
164SMAD protein complex assembly (GO:0007183)2.09393955
165G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.08894697
166regulation of cardiac muscle cell differentiation (GO:2000725)2.08683690
167monoubiquitinated protein deubiquitination (GO:0035520)2.08344490
168substrate-dependent cell migration (GO:0006929)2.07575258
169negative regulation of vascular permeability (GO:0043116)2.06949888
170positive regulation of glucose transport (GO:0010828)2.06702255
171suckling behavior (GO:0001967)2.05935846
172actin filament-based movement (GO:0030048)2.05804242
173dendritic spine organization (GO:0097061)2.05535759
174myofibril assembly (GO:0030239)2.05462102
175regulation of cholesterol homeostasis (GO:2000188)2.04226157
176regulation of steroid hormone biosynthetic process (GO:0090030)2.04060222
177protein heterotrimerization (GO:0070208)2.03906908
178positive regulation of osteoblast proliferation (GO:0033690)2.03683853
179actomyosin structure organization (GO:0031032)2.03082069
180UDP-N-acetylglucosamine metabolic process (GO:0006047)2.02581341
181endothelial cell morphogenesis (GO:0001886)2.01263374
182regulation of hippo signaling (GO:0035330)2.00794406

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.66970626
2GBX2_23144817_ChIP-Seq_PC3_Human3.11979329
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.75633531
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.54716468
5AR_21909140_ChIP-Seq_LNCAP_Human2.40064874
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.34174103
7TP53_16413492_ChIP-PET_HCT116_Human2.25659000
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23061289
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10995494
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.09051382
11* FOXA2_19822575_ChIP-Seq_HepG2_Human2.06421364
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.03203438
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97260563
14EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97102556
15RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97102556
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96900867
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96013317
18EP300_21415370_ChIP-Seq_HL-1_Mouse1.91294372
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89585291
20SALL4_18804426_ChIP-ChIP_XEN_Mouse1.87710802
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85154302
22* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.81914500
23DROSHA_22980978_ChIP-Seq_HELA_Human1.79387413
24AR_21572438_ChIP-Seq_LNCaP_Human1.77935368
25CLOCK_20551151_ChIP-Seq_293T_Human1.75217672
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74918500
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72978438
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.70878660
29TP53_18474530_ChIP-ChIP_U2OS_Human1.70274032
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.69113737
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68218977
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65116248
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.63953944
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63703967
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.62051738
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.57959595
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54746951
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53304795
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52886410
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52563411
41* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.51454939
42* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.51454939
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.51043234
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49854650
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.48404193
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.48237724
47AHR_22903824_ChIP-Seq_MCF-7_Human1.48096591
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47332480
49* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47286424
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.46871612
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.46513278
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45227765
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45226645
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.43492924
55ZNF263_19887448_ChIP-Seq_K562_Human1.42926666
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40397159
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.39769668
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38907022
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.38366374
60TAF15_26573619_Chip-Seq_HEK293_Human1.38266123
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37520233
62ZNF274_21170338_ChIP-Seq_K562_Hela1.37326195
63CJUN_26792858_Chip-Seq_BT549_Human1.37139135
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.36129241
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35940452
66FUS_26573619_Chip-Seq_HEK293_Human1.35895878
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34636453
68* STAT3_23295773_ChIP-Seq_U87_Human1.34535002
69P300_19829295_ChIP-Seq_ESCs_Human1.34435777
70RARB_27405468_Chip-Seq_BRAIN_Mouse1.34373466
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33192763
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.32002140
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30830083
74LXR_22158963_ChIP-Seq_LIVER_Mouse1.30797167
75* TCF4_18268006_ChIP-ChIP_LS174T_Human1.30735662
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30463430
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30463430
78BCAT_22108803_ChIP-Seq_LS180_Human1.28220065
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.27849740
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27841975
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27758955
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27152329
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26543085
84AR_25329375_ChIP-Seq_VCAP_Human1.26515564
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26273051
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25632040
87E2F7_22180533_ChIP-Seq_HELA_Human1.24109045
88CDX2_20551321_ChIP-Seq_CACO-2_Human1.23378390
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23140704
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21876930
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21748822
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.21410771
93ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21334883
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21142801
95* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20761700
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20593438
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20148723
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.20019961
99PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.17735820
100NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17482963
101FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17155606
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16795635
103* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16076350
104* HNF4A_19822575_ChIP-Seq_HepG2_Human1.15487052
105TCF4_23295773_ChIP-Seq_U87_Human1.14206675
106* RXR_22108803_ChIP-Seq_LS180_Human1.13643574
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13354708
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13069506
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12928041
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12155985
111BRD4_25478319_ChIP-Seq_HGPS_Human1.11891322
112SMAD3_21741376_ChIP-Seq_HESCs_Human1.11835246
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11644276
114* AR_19668381_ChIP-Seq_PC3_Human1.11103622
115MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09929433
116GATA2_21666600_ChIP-Seq_HMVEC_Human1.09479019
117HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08647845
118* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08640550
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07139330
120FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07013653
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06644658
122SOX2_20726797_ChIP-Seq_SW620_Human1.06541274
123PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05785038
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05113062
125EZH2_27294783_Chip-Seq_ESCs_Mouse1.03968101
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03780664
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03541441
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02586104
129E2F1_18555785_Chip-Seq_ESCs_Mouse1.02189616
130SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01435606
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01178106
132NANOG_18555785_Chip-Seq_ESCs_Mouse1.00785871
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00595215
134* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00448366
135TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00228286
136ISL1_27105846_Chip-Seq_CPCs_Mouse1.00051207
137TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99989214
138HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99671969
139CMYC_18555785_Chip-Seq_ESCs_Mouse0.99585598
140EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99582861
141PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98777787
142SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98327142
143ER_23166858_ChIP-Seq_MCF-7_Human0.98221300
144* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98159340
145UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96625381
146* RUNX2_22187159_ChIP-Seq_PCA_Human0.96416789
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94892605
148DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94790396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.04806797
2MP0008438_abnormal_cutaneous_collagen3.76987184
3MP0005623_abnormal_meninges_morphology2.84267604
4MP0005503_abnormal_tendon_morphology2.65953932
5MP0009780_abnormal_chondrocyte_physiolo2.50196680
6MP0000569_abnormal_digit_pigmentation2.50140857
7MP0005275_abnormal_skin_tensile2.49799919
8MP0005409_darkened_coat_color2.39664991
9MP0000751_myopathy2.26822813
10MP0003635_abnormal_synaptic_transmissio2.23091767
11MP0004272_abnormal_basement_membrane2.17935178
12MP0003045_fibrosis2.14769412
13MP0003705_abnormal_hypodermis_morpholog2.11246368
14MP0004484_altered_response_of2.06793385
15MP0004270_analgesia2.03983349
16MP0003880_abnormal_central_pattern1.93807002
17MP0003122_maternal_imprinting1.87879386
18MP0003279_aneurysm1.85155839
19MP0004084_abnormal_cardiac_muscle1.84926166
20MP0000013_abnormal_adipose_tissue1.82930253
21MP0002063_abnormal_learning/memory/cond1.77173595
22MP0008057_abnormal_DNA_replication1.76398616
23MP0002837_dystrophic_cardiac_calcinosis1.76398270
24MP0004145_abnormal_muscle_electrophysio1.76106862
25MP0003941_abnormal_skin_development1.75467926
26MP0003868_abnormal_feces_composition1.74972139
27MP0005257_abnormal_intraocular_pressure1.74178144
28MP0001299_abnormal_eye_distance/1.73960428
29MP0009745_abnormal_behavioral_response1.72559611
30MP0003091_abnormal_cell_migration1.72331627
31MP0010352_gastrointestinal_tract_polyps1.69248546
32MP0009384_cardiac_valve_regurgitation1.62285915
33MP0001958_emphysema1.61198298
34MP0004215_abnormal_myocardial_fiber1.61044033
35MP0000749_muscle_degeneration1.57985561
36MP0004036_abnormal_muscle_relaxation1.54546658
37MP0003566_abnormal_cell_adhesion1.51915160
38MP0003787_abnormal_imprinting1.51125237
39MP0009697_abnormal_copulation1.46619886
40MP0003890_abnormal_embryonic-extraembry1.46335527
41MP0009046_muscle_twitch1.45979079
42MP0005620_abnormal_muscle_contractility1.42383589
43MP0000733_abnormal_muscle_development1.41765593
44MP0010368_abnormal_lymphatic_system1.40774746
45MP0001501_abnormal_sleep_pattern1.39633263
46MP0002877_abnormal_melanocyte_morpholog1.39020221
47MP0004087_abnormal_muscle_fiber1.37573978
48MP0006138_congestive_heart_failure1.36749056
49MP0001177_atelectasis1.36339051
50MP0002064_seizures1.36302976
51MP0002108_abnormal_muscle_morphology1.35567601
52MP0003123_paternal_imprinting1.34355649
53MP0010234_abnormal_vibrissa_follicle1.34308327
54MP0003828_pulmonary_edema1.33686335
55MP0001915_intracranial_hemorrhage1.30191890
56MP0002572_abnormal_emotion/affect_behav1.29842858
57MP0000534_abnormal_ureter_morphology1.29615427
58MP0003942_abnormal_urinary_system1.27273082
59MP0004185_abnormal_adipocyte_glucose1.26731106
60MP0004130_abnormal_muscle_cell1.24944795
61MP0001661_extended_life_span1.22870262
62MP0004233_abnormal_muscle_weight1.22739931
63MP0005171_absent_coat_pigmentation1.21908032
64MP0002972_abnormal_cardiac_muscle1.20380739
65MP0001879_abnormal_lymphatic_vessel1.19509921
66MP0004510_myositis1.18658195
67MP0000428_abnormal_craniofacial_morphol1.18365424
68MP0002269_muscular_atrophy1.15063279
69MP0001486_abnormal_startle_reflex1.14653443
70MP0003385_abnormal_body_wall1.14262477
71MP0003300_gastrointestinal_ulcer1.12717099
72MP0001968_abnormal_touch/_nociception1.10517741
73MP0003937_abnormal_limbs/digits/tail_de1.09021342
74MP0000762_abnormal_tongue_morphology1.08785974
75MP0001440_abnormal_grooming_behavior1.07634933
76MP0005023_abnormal_wound_healing1.07351981
77MP0001666_abnormal_nutrient_absorption1.06131986
78MP0003252_abnormal_bile_duct1.06075202
79MP0002060_abnormal_skin_morphology1.04821211
80MP0002295_abnormal_pulmonary_circulatio1.04550184
81MP0004085_abnormal_heartbeat1.03688137
82MP0005330_cardiomyopathy1.03532253
83MP0001188_hyperpigmentation1.03138349
84MP0000759_abnormal_skeletal_muscle1.02424653
85MP0000003_abnormal_adipose_tissue1.02308812
86MP0010630_abnormal_cardiac_muscle1.02269818
87MP0008775_abnormal_heart_ventricle1.01741819
88MP0005369_muscle_phenotype1.01628044
89MP0000747_muscle_weakness1.01058315
90MP0008569_lethality_at_weaning0.99718163
91MP0002734_abnormal_mechanical_nocicepti0.99476243
92MP0009250_abnormal_appendicular_skeleto0.99174494
93MP0003935_abnormal_craniofacial_develop0.98988793
94MP0002697_abnormal_eye_size0.96441610
95MP0002106_abnormal_muscle_physiology0.96274148
96MP0002168_other_aberrant_phenotype0.94568611
97MP0003115_abnormal_respiratory_system0.94431577
98MP0002234_abnormal_pharynx_morphology0.94288710
99MP0002971_abnormal_brown_adipose0.93945021
100MP0002896_abnormal_bone_mineralization0.93489888
101MP0003950_abnormal_plasma_membrane0.93280204
102MP0002133_abnormal_respiratory_system0.92640347
103MP0005388_respiratory_system_phenotype0.92640347
104MP0003755_abnormal_palate_morphology0.92573965
105MP0000767_abnormal_smooth_muscle0.92380155
106MP0000432_abnormal_head_morphology0.89942428
107* MP0002128_abnormal_blood_circulation0.89880877
108MP0005360_urolithiasis0.89389416
109MP0005187_abnormal_penis_morphology0.88124871
110MP0005076_abnormal_cell_differentiation0.87752719
111MP0002272_abnormal_nervous_system0.86352290
112* MP0002086_abnormal_extraembryonic_tissu0.86251352
113MP0002009_preneoplasia0.84798169
114MP0001544_abnormal_cardiovascular_syste0.84558495
115MP0005385_cardiovascular_system_phenoty0.84558495
116MP0005595_abnormal_vascular_smooth0.84377179
117MP0005408_hypopigmentation0.82286895
118MP0005508_abnormal_skeleton_morphology0.81888366
119MP0000750_abnormal_muscle_regeneration0.81771971
120MP0002092_abnormal_eye_morphology0.81252398
121MP0002084_abnormal_developmental_patter0.81019869
122MP0010329_abnormal_lipoprotein_level0.80851810
123MP0000516_abnormal_urinary_system0.80621082
124MP0005367_renal/urinary_system_phenotyp0.80621082
125MP0005666_abnormal_adipose_tissue0.80407701
126MP0010678_abnormal_skin_adnexa0.80227182
127MP0002114_abnormal_axial_skeleton0.79279355
128MP0003984_embryonic_growth_retardation0.78945200
129MP0002067_abnormal_sensory_capabilities0.77793930
130MP0002909_abnormal_adrenal_gland0.77663900
131MP0002088_abnormal_embryonic_growth/wei0.77602036
132MP0002233_abnormal_nose_morphology0.77397210
133MP0006054_spinal_hemorrhage0.77095091
134MP0002938_white_spotting0.76649935
135MP0005085_abnormal_gallbladder_physiolo0.75941614
136MP0000462_abnormal_digestive_system0.75485503
137MP0002925_abnormal_cardiovascular_devel0.74892378
138MP0005451_abnormal_body_composition0.74222969
139MP0004134_abnormal_chest_morphology0.73602486
140MP0004883_abnormal_blood_vessel0.73580478
141MP0005167_abnormal_blood-brain_barrier0.72949566
142MP0004811_abnormal_neuron_physiology0.72901891
143MP0005670_abnormal_white_adipose0.72399574
144MP0002736_abnormal_nociception_after0.71556476
145MP0005375_adipose_tissue_phenotype0.69277911
146MP0002089_abnormal_postnatal_growth/wei0.69209787
147MP0003137_abnormal_impulse_conducting0.68524273

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)3.82198518
2Protrusio acetabuli (HP:0003179)3.73560575
3Premature rupture of membranes (HP:0001788)3.66642180
4Aortic aneurysm (HP:0004942)3.59071120
5Deep venous thrombosis (HP:0002625)3.53146847
6Shallow orbits (HP:0000586)3.11276522
7Nemaline bodies (HP:0003798)3.10801813
8Vascular tortuosity (HP:0004948)3.04221328
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.03140841
10Aortic dissection (HP:0002647)3.00394110
11Muscle fiber inclusion bodies (HP:0100299)2.97258298
12Focal seizures (HP:0007359)2.95442128
13Distal lower limb amyotrophy (HP:0008944)2.89753721
14Papillary thyroid carcinoma (HP:0002895)2.86150549
15Cerebral aneurysm (HP:0004944)2.84883114
16Arterial tortuosity (HP:0005116)2.82056982
17Lower limb amyotrophy (HP:0007210)2.78813802
18Atrophic scars (HP:0001075)2.74916209
19Absent frontal sinuses (HP:0002688)2.69870478
20Neonatal short-limb short stature (HP:0008921)2.63748461
21Broad metatarsal (HP:0001783)2.61440556
22Dilatation of the ascending aorta (HP:0005111)2.59769639
23Atonic seizures (HP:0010819)2.56900478
24Abnormality of carpal bone ossification (HP:0006257)2.54085917
25Mitral valve prolapse (HP:0001634)2.51454282
26Increased connective tissue (HP:0009025)2.49624689
27Right ventricular cardiomyopathy (HP:0011663)2.45467759
28Hypobetalipoproteinemia (HP:0003563)2.45133534
29Flat acetabular roof (HP:0003180)2.44424248
30Epileptic encephalopathy (HP:0200134)2.42964409
31Abnormality of the calf musculature (HP:0001430)2.40212192
32Abnormality of the common coagulation pathway (HP:0010990)2.39850823
33Dysmetric saccades (HP:0000641)2.37378671
34Cardiovascular calcification (HP:0011915)2.32769828
35Overgrowth (HP:0001548)2.32590412
36Hypoplastic ischia (HP:0003175)2.30876267
37Action tremor (HP:0002345)2.28759049
38Vertebral arch anomaly (HP:0008438)2.28316130
39Type 1 muscle fiber predominance (HP:0003803)2.26816248
40Genetic anticipation (HP:0003743)2.24947196
41Sudden death (HP:0001699)2.24871548
42Macroorchidism (HP:0000053)2.24842408
43Febrile seizures (HP:0002373)2.24688207
44Renal duplication (HP:0000075)2.24157882
45Limited hip movement (HP:0008800)2.21378736
46Limited elbow extension (HP:0001377)2.19515652
47Distal arthrogryposis (HP:0005684)2.19019855
48Hypolipoproteinemia (HP:0010981)2.18018927
49Spinal cord lesions (HP:0100561)2.17480758
50Syringomyelia (HP:0003396)2.17480758
51Mitral stenosis (HP:0001718)2.17340661
52Increased variability in muscle fiber diameter (HP:0003557)2.16916050
53Abnormal hand bone ossification (HP:0010660)2.16829138
54Small epiphyses (HP:0010585)2.16410958
55Asymmetry of the thorax (HP:0001555)2.14067780
56Progressive cerebellar ataxia (HP:0002073)2.13717567
57Abnormal ossification of hand bones (HP:0005921)2.13545509
58Atrial fibrillation (HP:0005110)2.13537968
59Aneurysm (HP:0002617)2.13373443
60Prolonged partial thromboplastin time (HP:0003645)2.13291036
61Mildly elevated creatine phosphokinase (HP:0008180)2.12651845
62Genu recurvatum (HP:0002816)2.11127898
63Acanthocytosis (HP:0001927)2.10474422
64Ankle contracture (HP:0006466)2.10206667
65Scapular winging (HP:0003691)2.09930314
66Heterotopia (HP:0002282)2.06601119
67Buphthalmos (HP:0000557)2.06389207
68Abnormality of the nasal septum (HP:0000419)2.06190842
69Abnormal foot bone ossification (HP:0010675)2.06101728
70Abnormality of the acetabulum (HP:0003170)2.06011750
71Urethral obstruction (HP:0000796)2.05437519
72Spinal rigidity (HP:0003306)2.05044793
73Vascular calcification (HP:0004934)2.04733128
74Hyporeflexia of lower limbs (HP:0002600)2.04200624
75Broad-based gait (HP:0002136)2.03695078
76Broad palm (HP:0001169)2.03629839
77Primary atrial arrhythmia (HP:0001692)2.02819706
78Fragile skin (HP:0001030)2.01917861
79Subacute progressive viral hepatitis (HP:0006572)1.99215283
80Bladder diverticulum (HP:0000015)1.98833641
81Abnormality of skeletal muscle fiber size (HP:0012084)1.97502231
82Muscle fiber splitting (HP:0003555)1.96561214
83Abnormality of the ischium (HP:0003174)1.95892408
84Cupped ribs (HP:0000887)1.94518682
85Short chin (HP:0000331)1.93411492
86Absence seizures (HP:0002121)1.92616015
87Hematochezia (HP:0002573)1.92401714
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92325959
89Submucous cleft hard palate (HP:0000176)1.90730915
90Aqueductal stenosis (HP:0002410)1.89791816
91Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88659540
92Papilledema (HP:0001085)1.88189403
93Insidious onset (HP:0003587)1.87378493
94Termporal pattern (HP:0011008)1.87378493
95Difficulty running (HP:0009046)1.87300450
96Wormian bones (HP:0002645)1.85619128
97Wide anterior fontanel (HP:0000260)1.85394026
98Aplasia involving bones of the extremities (HP:0009825)1.85218105
99Aplasia involving bones of the upper limbs (HP:0009823)1.85218105
100Aplasia of the phalanges of the hand (HP:0009802)1.85218105
101Calf muscle hypertrophy (HP:0008981)1.84502931
102Supraventricular arrhythmia (HP:0005115)1.84132965
103Narrow palate (HP:0000189)1.83453485
104Hypoalphalipoproteinemia (HP:0003233)1.83172987
105Gaze-evoked nystagmus (HP:0000640)1.83150626
106Cervical subluxation (HP:0003308)1.83083426
107Abnormal tarsal ossification (HP:0008369)1.83072040
108Hepatoblastoma (HP:0002884)1.82520921
109EMG: myopathic abnormalities (HP:0003458)1.82216344
110Coronal craniosynostosis (HP:0004440)1.82090079
111Exercise-induced myalgia (HP:0003738)1.81852054
112Muscle hypertrophy of the lower extremities (HP:0008968)1.81758912
113Bowel diverticulosis (HP:0005222)1.80888069
114Spondylolisthesis (HP:0003302)1.80860887
115Bell-shaped thorax (HP:0001591)1.80768140
116Supraventricular tachycardia (HP:0004755)1.79389753
117Exotropia (HP:0000577)1.79199138
118Ulnar bowing (HP:0003031)1.79144447
119Abnormal delivery (HP:0001787)1.79081685
120Subaortic stenosis (HP:0001682)1.78865558
121Abnormality of the left ventricular outflow tract (HP:0011103)1.78865558
122Knee flexion contracture (HP:0006380)1.77784631
123Difficulty climbing stairs (HP:0003551)1.77656621
124Rectal prolapse (HP:0002035)1.75803334
125Abnormality of the intrinsic pathway (HP:0010989)1.75317189
126Osteolytic defects of the hand bones (HP:0009699)1.75169338
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.75169338
128Ankyloglossia (HP:0010296)1.75142220
129Slender build (HP:0001533)1.74924322
130Abnormality of the frontal sinuses (HP:0002687)1.74556338
131Striae distensae (HP:0001065)1.74109192
132Volvulus (HP:0002580)1.73546779
133Menorrhagia (HP:0000132)1.72877422
134Advanced eruption of teeth (HP:0006288)1.72017969
135Dislocated radial head (HP:0003083)1.71832938
136Resting tremor (HP:0002322)1.71178747
137Round ear (HP:0100830)1.71056976
138Soft skin (HP:0000977)1.70656854
139Abnormality of the wing of the ilium (HP:0011867)1.70446658
140Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.70385187
141Wrist flexion contracture (HP:0001239)1.70027923
142Enlarged penis (HP:0000040)1.70015040
143Increased density of long bones (HP:0006392)1.68158943
144Scanning speech (HP:0002168)1.67428893
145Drooling (HP:0002307)1.66775680
146Excessive salivation (HP:0003781)1.66775680
147Back pain (HP:0003418)1.66688372
148Pulmonic stenosis (HP:0001642)1.65792208
149Microglossia (HP:0000171)1.65673027
150Impaired pain sensation (HP:0007328)1.65651865
151Abnormality of pain sensation (HP:0010832)1.65651865
152Impaired vibration sensation in the lower limbs (HP:0002166)1.64614953
153Mesomelia (HP:0003027)1.64564753
154Visual hallucinations (HP:0002367)1.63654493
155Dialeptic seizures (HP:0011146)1.63225802
156Delayed closure of the anterior fontanelle (HP:0001476)1.62248739
157Renovascular hypertension (HP:0100817)1.61150526
158Hypercholesterolemia (HP:0003124)1.60630020
159Abnormality of the calcaneus (HP:0008364)1.57384885
160Elbow flexion contracture (HP:0002987)1.57346729
161Increased nuchal translucency (HP:0010880)1.55727587
162Ulnar deviation of the wrist (HP:0003049)1.54853778
163Complement deficiency (HP:0004431)1.53666162
164Missing ribs (HP:0000921)1.52600468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.27096609
2MST1R3.16736476
3NTRK33.10891977
4FRK2.74760374
5STK392.67825816
6TTN2.53761709
7DMPK2.53147825
8MET2.48966593
9PIK3CA2.26639922
10MAP3K42.13732989
11RIPK42.12607041
12PLK22.08727925
13CDK122.04905746
14DDR21.98907308
15WNK41.89613030
16CAMK1G1.83913255
17RIPK11.80440220
18LATS11.77700421
19MAP3K91.73548996
20STK38L1.69675164
21FER1.65417378
22LMTK21.58872854
23MINK11.56464610
24PTK2B1.55493866
25FGFR41.53520302
26SCYL21.49579245
27CAMK1D1.47682468
28PAK31.44781655
29PDGFRA1.43531860
30CAMKK11.39965654
31CASK1.37465824
32ICK1.35564850
33PAK61.34622850
34DAPK21.33176288
35MAP2K41.32348550
36BRSK21.30773324
37EEF2K1.27402405
38FGFR21.26168350
39NTRK11.25401501
40EIF2AK11.21282736
41MAP2K71.20604708
42LATS21.16022966
43WNK11.13066454
44MARK11.11916576
45PHKG11.11094677
46PHKG21.11094677
47KSR11.09009986
48STK381.08568331
49OBSCN1.07509260
50ERBB41.04653805
51SIK21.04450727
52EPHA21.03353519
53MAP3K71.02634670
54MAP3K121.02475164
55CAMKK21.02301165
56PBK1.02114223
57TGFBR21.00382641
58PNCK0.98997981
59RET0.98496960
60NUAK10.98109907
61BRD40.95377912
62CDK50.94880905
63MOS0.94819875
64SGK30.94037910
65PRKAA20.91928762
66FGFR30.90475357
67SGK10.89435733
68MAP3K130.88409982
69CAMK10.86499375
70PDGFRB0.86237880
71CAMK2A0.83425473
72KSR20.82995547
73MAP3K20.82613083
74NEK10.82043181
75ZAK0.81989654
76DAPK10.79551186
77PTK20.79541082
78MTOR0.79494409
79SGK20.79321863
80FGFR10.79226498
81TRPM70.78696446
82PRKD30.78569855
83STK110.76671207
84MELK0.74970999
85GRK50.74618407
86PRKCE0.72796369
87TYRO30.72312407
88PAK20.72295644
89PDK10.70859579
90BMX0.70499269
91ROCK10.69772928
92AKT30.69521603
93PKN20.69293016
94BCR0.68813338
95PRPF4B0.65760948
96STK30.65011062
97PRKCH0.64439352
98ROCK20.63765267
99CAMK2D0.63221153
100BMPR20.62721074
101TRIB30.62618671
102PDK20.62535190
103MAP2K10.62352654
104RPS6KB10.62239109
105CAMK2B0.61466633
106ACVR1B0.61312047
107PIK3CG0.60390235
108CDC42BPA0.59911988
109SGK4940.59366947
110EPHB20.59072239
111PDPK10.58342751
112NEK20.58147540
113EIF2AK30.58017436
114ERBB30.57332596
115CDK60.57006862
116CDK80.56163401
117NEK90.55509197
118* CSNK1E0.53984729
119CAMK40.53751787
120BMPR1B0.53338450
121TIE10.51777833
122RAF10.49817383
123SIK10.47587609
124PRKG20.47091820
125FYN0.47083457
126MYLK0.46613411
127PRKD10.45992218
128INSR0.45951243
129MAPK100.45683261
130ERBB20.44756063
131PRKAA10.44371270
132RPS6KA30.44216791
133RPS6KB20.42976098
134ALK0.42906614
135FES0.42813581
136MAPK120.42795785
137WEE10.41137154
138NEK60.40086442
139YES10.39700713
140CDK180.39314926
141CDK140.39303414
142OXSR10.39177445
143SGK2230.38868308
144GSK3A0.38260982
145ATM0.34028228

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046102.42630056
2Long-term potentiation_Homo sapiens_hsa047202.18212218
3Nicotine addiction_Homo sapiens_hsa050332.17965362
4Fatty acid biosynthesis_Homo sapiens_hsa000612.07518255
5Circadian entrainment_Homo sapiens_hsa047131.96418264
6Dilated cardiomyopathy_Homo sapiens_hsa054141.90982799
7Salivary secretion_Homo sapiens_hsa049701.88133633
8Renin secretion_Homo sapiens_hsa049241.77482237
9Amphetamine addiction_Homo sapiens_hsa050311.75288695
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74933545
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.70119024
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.66851051
13Glutamatergic synapse_Homo sapiens_hsa047241.64997357
14Olfactory transduction_Homo sapiens_hsa047401.63319058
15* Oxytocin signaling pathway_Homo sapiens_hsa049211.59822947
16ECM-receptor interaction_Homo sapiens_hsa045121.58520534
17Arginine biosynthesis_Homo sapiens_hsa002201.57929578
18Morphine addiction_Homo sapiens_hsa050321.57697662
19Gastric acid secretion_Homo sapiens_hsa049711.55920407
20Long-term depression_Homo sapiens_hsa047301.52176050
21* Focal adhesion_Homo sapiens_hsa045101.51309147
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51220634
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49028166
24Dopaminergic synapse_Homo sapiens_hsa047281.48717221
25GABAergic synapse_Homo sapiens_hsa047271.41992904
26Glioma_Homo sapiens_hsa052141.41437752
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.41022611
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39079177
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38210197
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35539642
31Calcium signaling pathway_Homo sapiens_hsa040201.34707476
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33837030
33* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.32261344
34Cholinergic synapse_Homo sapiens_hsa047251.31815083
35GnRH signaling pathway_Homo sapiens_hsa049121.30719122
36Synaptic vesicle cycle_Homo sapiens_hsa047211.25860702
37Gap junction_Homo sapiens_hsa045401.25248465
38Insulin secretion_Homo sapiens_hsa049111.24605393
39* cAMP signaling pathway_Homo sapiens_hsa040241.23995057
40Adherens junction_Homo sapiens_hsa045201.23076338
41Lysine degradation_Homo sapiens_hsa003101.22163240
42PPAR signaling pathway_Homo sapiens_hsa033201.21921078
43Taste transduction_Homo sapiens_hsa047421.20268765
44Circadian rhythm_Homo sapiens_hsa047101.19734126
45* Proteoglycans in cancer_Homo sapiens_hsa052051.15869964
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14593064
47Estrogen signaling pathway_Homo sapiens_hsa049151.14461166
48Fat digestion and absorption_Homo sapiens_hsa049751.09781961
49Melanogenesis_Homo sapiens_hsa049161.08070847
50Fatty acid degradation_Homo sapiens_hsa000711.07191094
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06958187
52ErbB signaling pathway_Homo sapiens_hsa040121.06932502
53Serotonergic synapse_Homo sapiens_hsa047261.06420184
54* Vascular smooth muscle contraction_Homo sapiens_hsa042701.05047242
55* Axon guidance_Homo sapiens_hsa043601.04004861
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03716827
57Vitamin B6 metabolism_Homo sapiens_hsa007501.03715410
58Non-homologous end-joining_Homo sapiens_hsa034501.03580227
59Starch and sucrose metabolism_Homo sapiens_hsa005001.03418837
60Amoebiasis_Homo sapiens_hsa051461.02447657
61Thyroid cancer_Homo sapiens_hsa052161.00945669
62Rap1 signaling pathway_Homo sapiens_hsa040151.00707648
63Type II diabetes mellitus_Homo sapiens_hsa049301.00613033
64* Platelet activation_Homo sapiens_hsa046110.98961178
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98123877
66Cocaine addiction_Homo sapiens_hsa050300.98012433
67* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97847463
68Dorso-ventral axis formation_Homo sapiens_hsa043200.97521824
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96541175
70Bile secretion_Homo sapiens_hsa049760.96299531
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95532576
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95188971
73Insulin resistance_Homo sapiens_hsa049310.94881351
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91664539
75Fatty acid metabolism_Homo sapiens_hsa012120.89289617
76MAPK signaling pathway_Homo sapiens_hsa040100.87477975
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86660633
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85235065
79Melanoma_Homo sapiens_hsa052180.84622923
80Thyroid hormone synthesis_Homo sapiens_hsa049180.83880379
81Histidine metabolism_Homo sapiens_hsa003400.82799010
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.82479676
83Nitrogen metabolism_Homo sapiens_hsa009100.81057634
84Tight junction_Homo sapiens_hsa045300.80497442
85Renal cell carcinoma_Homo sapiens_hsa052110.80463331
86mTOR signaling pathway_Homo sapiens_hsa041500.80238174
87Ras signaling pathway_Homo sapiens_hsa040140.79777140
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.78914851
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78096234
90ABC transporters_Homo sapiens_hsa020100.77861466
91VEGF signaling pathway_Homo sapiens_hsa043700.77364712
92AMPK signaling pathway_Homo sapiens_hsa041520.77069167
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.76743958
94Renin-angiotensin system_Homo sapiens_hsa046140.76605032
95Choline metabolism in cancer_Homo sapiens_hsa052310.76288925
96MicroRNAs in cancer_Homo sapiens_hsa052060.75852381
97TGF-beta signaling pathway_Homo sapiens_hsa043500.75354285
98Basal cell carcinoma_Homo sapiens_hsa052170.74898108
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.74879297
100Glucagon signaling pathway_Homo sapiens_hsa049220.74296685
101Hippo signaling pathway_Homo sapiens_hsa043900.71356258
102Mineral absorption_Homo sapiens_hsa049780.70917568
103Small cell lung cancer_Homo sapiens_hsa052220.69339122
104Chronic myeloid leukemia_Homo sapiens_hsa052200.69117038
105Pancreatic secretion_Homo sapiens_hsa049720.68571068
106Non-small cell lung cancer_Homo sapiens_hsa052230.67230897
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67075974
108* Wnt signaling pathway_Homo sapiens_hsa043100.66656585
109* Leukocyte transendothelial migration_Homo sapiens_hsa046700.64339630
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64329268
111Endometrial cancer_Homo sapiens_hsa052130.63889269
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62655062
113Pancreatic cancer_Homo sapiens_hsa052120.62496436
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62446656
115HIF-1 signaling pathway_Homo sapiens_hsa040660.61957323
116African trypanosomiasis_Homo sapiens_hsa051430.61879214
117Hedgehog signaling pathway_Homo sapiens_hsa043400.61442171
118* Pathways in cancer_Homo sapiens_hsa052000.60432190
119Oocyte meiosis_Homo sapiens_hsa041140.59313990
120Inositol phosphate metabolism_Homo sapiens_hsa005620.58313321
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58033340
122Protein digestion and absorption_Homo sapiens_hsa049740.57853827
123Insulin signaling pathway_Homo sapiens_hsa049100.57250027
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57192652
125* Salmonella infection_Homo sapiens_hsa051320.56946413
126Ovarian steroidogenesis_Homo sapiens_hsa049130.56810774
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56794073
128FoxO signaling pathway_Homo sapiens_hsa040680.56723885
129Colorectal cancer_Homo sapiens_hsa052100.56032959
130Vitamin digestion and absorption_Homo sapiens_hsa049770.55912191
131Propanoate metabolism_Homo sapiens_hsa006400.54878507
132Prostate cancer_Homo sapiens_hsa052150.54021763
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.53418391
134Endocytosis_Homo sapiens_hsa041440.52789600
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52646163
136Viral myocarditis_Homo sapiens_hsa054160.52231544
137Bladder cancer_Homo sapiens_hsa052190.51686912

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