ROGDI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein of unknown function. Loss-of-function mutation in this gene cause Kohlschutter-Tonz syndrome. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.62910398
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.15459492
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.74265257
4regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.72189846
5regulation of synaptic vesicle exocytosis (GO:2000300)4.62989510
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.60407652
7glutamate secretion (GO:0014047)4.44782867
8protein localization to synapse (GO:0035418)4.38691664
9sodium ion export (GO:0071436)4.36191880
10vocalization behavior (GO:0071625)4.28973736
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.26796376
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.25936970
13regulation of synaptic vesicle transport (GO:1902803)4.25230287
14positive regulation of synapse maturation (GO:0090129)4.23011411
15neuronal ion channel clustering (GO:0045161)4.20643391
16regulation of glutamate receptor signaling pathway (GO:1900449)4.18853644
17glutamate receptor signaling pathway (GO:0007215)4.16103398
18neurotransmitter-gated ion channel clustering (GO:0072578)4.15500210
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.14279263
20synaptic vesicle maturation (GO:0016188)4.13439249
21synaptic transmission, glutamatergic (GO:0035249)4.04859144
22cerebellar granule cell differentiation (GO:0021707)4.03251295
23axon ensheathment in central nervous system (GO:0032291)3.98966159
24central nervous system myelination (GO:0022010)3.98966159
25regulation of ARF protein signal transduction (GO:0032012)3.97968082
26neuron-neuron synaptic transmission (GO:0007270)3.97027486
27gamma-aminobutyric acid signaling pathway (GO:0007214)3.94317624
28G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.93536754
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.87030704
30transferrin transport (GO:0033572)3.83217348
31L-amino acid import (GO:0043092)3.82044278
32synaptic vesicle endocytosis (GO:0048488)3.78638162
33neuronal action potential propagation (GO:0019227)3.72402042
34neuron cell-cell adhesion (GO:0007158)3.66045093
35neurotransmitter secretion (GO:0007269)3.62882740
36regulation of synapse maturation (GO:0090128)3.62072753
37positive regulation of membrane potential (GO:0045838)3.61428989
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60235511
39regulation of vesicle fusion (GO:0031338)3.58052119
40ATP hydrolysis coupled proton transport (GO:0015991)3.57298854
41energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.57298854
42long-term memory (GO:0007616)3.56350251
43ferric iron transport (GO:0015682)3.51300494
44trivalent inorganic cation transport (GO:0072512)3.51300494
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.50306653
46regulation of neuronal synaptic plasticity (GO:0048168)3.50075310
47long-term synaptic potentiation (GO:0060291)3.48708444
48locomotory exploration behavior (GO:0035641)3.46704001
49neuromuscular process controlling posture (GO:0050884)3.41834976
50potassium ion homeostasis (GO:0055075)3.41326196
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.39923597
52establishment of mitochondrion localization (GO:0051654)3.39126968
53response to histamine (GO:0034776)3.38579679
54regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.37695130
55regulation of synapse structural plasticity (GO:0051823)3.32548304
56regulation of neurotransmitter levels (GO:0001505)3.29808832
57behavioral defense response (GO:0002209)3.29041197
58behavioral fear response (GO:0001662)3.29041197
59regulation of postsynaptic membrane potential (GO:0060078)3.27472011
60regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.27150656
61regulation of neurotransmitter secretion (GO:0046928)3.26445662
62amino acid import (GO:0043090)3.25744296
63serotonin metabolic process (GO:0042428)3.25702927
64positive regulation of neurotransmitter transport (GO:0051590)3.21374638
65exploration behavior (GO:0035640)3.20840886
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.20209302
67membrane depolarization during action potential (GO:0086010)3.18974430
68negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.18795936
69neuromuscular process controlling balance (GO:0050885)3.18771707
70regulation of long-term neuronal synaptic plasticity (GO:0048169)3.18763738
71regulation of synaptic plasticity (GO:0048167)3.15622956
72neurotransmitter transport (GO:0006836)3.15394802
73synaptic vesicle transport (GO:0048489)3.14969079
74establishment of synaptic vesicle localization (GO:0097480)3.14969079
75detection of calcium ion (GO:0005513)3.14587635
76layer formation in cerebral cortex (GO:0021819)3.13801199
77regulation of synaptic transmission, glutamatergic (GO:0051966)3.13550528
78fear response (GO:0042596)3.13339494
79regulation of glutamate secretion (GO:0014048)3.12518314
80phagosome maturation (GO:0090382)3.11357487
81adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.10480383
82cellular potassium ion homeostasis (GO:0030007)3.09920066
83mitochondrion transport along microtubule (GO:0047497)3.07135364
84establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.07135364
85positive regulation of dendritic spine development (GO:0060999)3.05678698
86G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.05385860
87activation of protein kinase A activity (GO:0034199)3.05248528
88peptidyl-tyrosine autophosphorylation (GO:0038083)3.01539364
89positive regulation of synaptic transmission, GABAergic (GO:0032230)3.00391022
90presynaptic membrane assembly (GO:0097105)3.00317313
91cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99385383
92protein localization to cilium (GO:0061512)2.98673828
93membrane depolarization (GO:0051899)2.98138390
94regulation of neurotransmitter transport (GO:0051588)2.98137152
95synaptic transmission (GO:0007268)2.95935677
96synaptic transmission, dopaminergic (GO:0001963)2.95138608
97behavioral response to cocaine (GO:0048148)2.94412245
98response to pheromone (GO:0019236)2.93954721
99positive regulation of neurotransmitter secretion (GO:0001956)2.93910495
100dopamine receptor signaling pathway (GO:0007212)2.92953687
101potassium ion import (GO:0010107)2.92471099
102postsynaptic membrane organization (GO:0001941)2.90108329
103membrane hyperpolarization (GO:0060081)2.87944646
104urinary tract smooth muscle contraction (GO:0014848)2.87854151
105regulation of dopamine metabolic process (GO:0042053)2.86132921
106regulation of catecholamine metabolic process (GO:0042069)2.86132921
107regulation of voltage-gated calcium channel activity (GO:1901385)2.85944750
108primary amino compound metabolic process (GO:1901160)2.84098677
109presynaptic membrane organization (GO:0097090)2.83821426
110dendritic spine morphogenesis (GO:0060997)2.82823897
111establishment of vesicle localization (GO:0051650)2.82165985
112innervation (GO:0060384)2.80992262
113startle response (GO:0001964)2.80719392
114cerebellar Purkinje cell differentiation (GO:0021702)2.80546066
115negative regulation of cytosolic calcium ion concentration (GO:0051481)2.80355981
116cerebellar Purkinje cell layer development (GO:0021680)2.80258537
117regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.78101748
118regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.78101748
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.77712231
120detection of light stimulus involved in sensory perception (GO:0050962)2.77668339
121detection of light stimulus involved in visual perception (GO:0050908)2.77668339
122regulation of exocytosis (GO:0017157)2.76917028
123dendritic spine organization (GO:0097061)2.76712035
124cell communication by electrical coupling (GO:0010644)2.75943660
125regulation of synaptic transmission (GO:0050804)2.75313648
126learning (GO:0007612)2.74757085
127positive regulation of dendritic spine morphogenesis (GO:0061003)2.74258846
128positive regulation of synaptic transmission (GO:0050806)2.74189577
129cell migration in hindbrain (GO:0021535)2.70087023
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.68733822
131cell-cell junction maintenance (GO:0045217)2.65066342
132cellular sodium ion homeostasis (GO:0006883)2.65002813
133cell communication involved in cardiac conduction (GO:0086065)2.63322797
134detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.55365860
135detection of temperature stimulus involved in sensory perception (GO:0050961)2.55365860
136cell differentiation in hindbrain (GO:0021533)2.54795705
137positive regulation of Rap GTPase activity (GO:0032854)2.53691628
138positive regulation of exocytosis (GO:0045921)2.52195434
139acidic amino acid transport (GO:0015800)2.52086637
140gamma-aminobutyric acid transport (GO:0015812)2.50508434
141cellular response to monoamine stimulus (GO:0071868)2.47109655
142cellular response to catecholamine stimulus (GO:0071870)2.47109655

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.54827798
2GBX2_23144817_ChIP-Seq_PC3_Human4.01362548
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.76617676
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.43394111
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.32064921
6REST_21632747_ChIP-Seq_MESCs_Mouse3.05929574
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.84850591
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.79853962
9* LXR_22292898_ChIP-Seq_THP-1_Human2.69688998
10REST_18959480_ChIP-ChIP_MESCs_Mouse2.68697912
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55745235
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50943368
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40497286
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39953476
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.35491226
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35148979
17DROSHA_22980978_ChIP-Seq_HELA_Human2.28433506
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25630390
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21651098
20KDM2B_26808549_Chip-Seq_K562_Human2.17385654
21* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.16448702
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16311730
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.15577264
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14349053
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10474242
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.07160881
27ZFP281_18757296_ChIP-ChIP_E14_Mouse2.07117894
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06805567
29EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04142303
30RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04142303
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.98366418
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98245077
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97167458
34* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.96062109
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94416625
36P68_20966046_ChIP-Seq_HELA_Human1.92475840
37CTCF_27219007_Chip-Seq_Bcells_Human1.89302319
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88455324
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.87412054
40VDR_22108803_ChIP-Seq_LS180_Human1.87086434
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.85936340
42KDM2B_26808549_Chip-Seq_DND41_Human1.81880943
43SMC4_20622854_ChIP-Seq_HELA_Human1.79543406
44TAF15_26573619_Chip-Seq_HEK293_Human1.75942578
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.75772552
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72349371
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69393636
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69333600
49SMAD4_21799915_ChIP-Seq_A2780_Human1.67475008
50* VDR_21846776_ChIP-Seq_THP-1_Human1.67292916
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66592816
52SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.64619079
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61689353
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.59129306
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56316107
56* RACK7_27058665_Chip-Seq_MCF-7_Human1.55221165
57P300_19829295_ChIP-Seq_ESCs_Human1.53903267
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52193978
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.48906985
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48320801
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43959497
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.43583986
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43564352
64* CREB1_26743006_Chip-Seq_LNCaP_Human1.42741966
65OCT4_19829295_ChIP-Seq_ESCs_Human1.42101993
66SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.39989975
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38952233
68TET1_21490601_ChIP-Seq_MESCs_Mouse1.38641473
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38325461
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36113791
71* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.35985463
72BCOR_27268052_Chip-Seq_Bcells_Human1.34635464
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.34441873
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33955940
75BCL6_27268052_Chip-Seq_Bcells_Human1.33834473
76TCF7_22412390_ChIP-Seq_EML_Mouse1.33824231
77AR_25329375_ChIP-Seq_VCAP_Human1.33508220
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.31813479
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30527916
80SA1_27219007_Chip-Seq_Bcells_Human1.30134940
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27999300
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25236243
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24675917
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.24622031
85MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.22236760
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21982074
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21720630
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21542431
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.20432598
90IGF1R_20145208_ChIP-Seq_DFB_Human1.20298622
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19439235
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18535935
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18439430
94OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18329303
95RNF2_27304074_Chip-Seq_NSC_Mouse1.16510214
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16096313
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15980987
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13858013
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13747813
100STAT3_23295773_ChIP-Seq_U87_Human1.13560850
101CTCF_20526341_ChIP-Seq_ESCs_Human1.13517565
102PHF8_20622854_ChIP-Seq_HELA_Human1.13269081
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13156778
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11076943
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10910862
106ELK3_25401928_ChIP-Seq_HUVEC_Human1.10728184
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.10177372
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09987632
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.09771363
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09579938
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07774814
112TP63_22573176_ChIP-Seq_HFKS_Human1.07217234
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06672895
114TCF4_23295773_ChIP-Seq_U87_Human1.06510442
115SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05882055
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05650064
117E2F1_20622854_ChIP-Seq_HELA_Human1.04923822
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.04059551
119CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03954181
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01744408
121SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00585280
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99743779
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.98863685
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98817025
125AR_19668381_ChIP-Seq_PC3_Human0.98816736
126KLF4_19829295_ChIP-Seq_ESCs_Human0.98148028
127ZNF274_21170338_ChIP-Seq_K562_Hela0.97473457
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.97410323
129* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97005911
130CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95805236
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95794515
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94996103
133TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94549875
134VDR_24763502_ChIP-Seq_THP-1_Human0.93626520
135ER_23166858_ChIP-Seq_MCF-7_Human0.93611453
136PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93529591
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92733969
138RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92531089
139JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92475866
140RUNX2_22187159_ChIP-Seq_PCA_Human0.92075113
141SOX2_18555785_Chip-Seq_ESCs_Mouse0.92047956
142PIAS1_25552417_ChIP-Seq_VCAP_Human0.91291364
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.91227488
144PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91084936
145SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90685985
146JUN_21703547_ChIP-Seq_K562_Human0.89152640
147P53_22387025_ChIP-Seq_ESCs_Mouse0.88867813
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87351401
149RING1B_27294783_Chip-Seq_ESCs_Mouse0.87056632
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86428213
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86119022
152CMYC_18555785_Chip-Seq_ESCs_Mouse0.86057176
153STAT3_18555785_Chip-Seq_ESCs_Mouse0.85814890
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85437373
155ARNT_22903824_ChIP-Seq_MCF-7_Human0.85257457
156RUNX1_27457419_Chip-Seq_LIVER_Mouse0.85054490
157OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85051205
158NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84665219
159AHR_22903824_ChIP-Seq_MCF-7_Human0.84450699
160E2F1_18555785_Chip-Seq_ESCs_Mouse0.84416104
161SOX9_26525672_Chip-Seq_HEART_Mouse0.84122685
162SMAD3_21741376_ChIP-Seq_ESCs_Human0.84027239
163TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82940746

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.22022807
2MP0003880_abnormal_central_pattern4.71192637
3MP0003635_abnormal_synaptic_transmissio3.54158212
4MP0009745_abnormal_behavioral_response3.08247858
5MP0002064_seizures2.94985691
6MP0002063_abnormal_learning/memory/cond2.92688478
7MP0009046_muscle_twitch2.84543781
8MP0001968_abnormal_touch/_nociception2.82870899
9MP0004270_analgesia2.77880817
10MP0002876_abnormal_thyroid_physiology2.76638606
11MP0002572_abnormal_emotion/affect_behav2.59505901
12MP0002736_abnormal_nociception_after2.57208178
13MP0002272_abnormal_nervous_system2.54544233
14MP0003787_abnormal_imprinting2.44265336
15MP0002735_abnormal_chemical_nociception2.38113784
16MP0002822_catalepsy2.29768950
17MP0001984_abnormal_olfaction2.29421351
18MP0002734_abnormal_mechanical_nocicepti2.24328140
19MP0001501_abnormal_sleep_pattern2.23211641
20MP0003879_abnormal_hair_cell2.16124029
21MP0005551_abnormal_eye_electrophysiolog2.11410950
22MP0001440_abnormal_grooming_behavior2.05222082
23MP0005645_abnormal_hypothalamus_physiol2.04160494
24MP0010386_abnormal_urinary_bladder2.03496413
25MP0003183_abnormal_peptide_metabolism2.01758549
26MP0005423_abnormal_somatic_nervous2.00326529
27MP0001486_abnormal_startle_reflex1.98457476
28MP0006276_abnormal_autonomic_nervous1.97195317
29MP0003690_abnormal_glial_cell1.95522840
30MP0001502_abnormal_circadian_rhythm1.91154534
31MP0003123_paternal_imprinting1.88956751
32MP0002163_abnormal_gland_morphology1.87762994
33MP0005646_abnormal_pituitary_gland1.87497287
34MP0002067_abnormal_sensory_capabilities1.87144628
35MP0001970_abnormal_pain_threshold1.74921176
36MP0003122_maternal_imprinting1.74498155
37MP0000920_abnormal_myelination1.71011784
38MP0001346_abnormal_lacrimal_gland1.70721936
39MP0002184_abnormal_innervation1.65632211
40MP0002733_abnormal_thermal_nociception1.60922613
41MP0001188_hyperpigmentation1.60465230
42MP0001905_abnormal_dopamine_level1.56545967
43MP0001529_abnormal_vocalization1.55848370
44MP0006072_abnormal_retinal_apoptosis1.52934438
45MP0002909_abnormal_adrenal_gland1.51084271
46MP0004142_abnormal_muscle_tone1.48744863
47MP0005310_abnormal_salivary_gland1.43021392
48MP0002638_abnormal_pupillary_reflex1.42337664
49MP0002557_abnormal_social/conspecific_i1.42087586
50MP0008877_abnormal_DNA_methylation1.41369174
51MP0008569_lethality_at_weaning1.39757574
52MP0003075_altered_response_to1.39747175
53MP0005379_endocrine/exocrine_gland_phen1.38203701
54MP0004510_myositis1.36158833
55MP0006292_abnormal_olfactory_placode1.34692677
56MP0004130_abnormal_muscle_cell1.32136646
57MP0005386_behavior/neurological_phenoty1.31604156
58MP0004924_abnormal_behavior1.31604156
59MP0005058_abnormal_lysosome_morphology1.31007367
60MP0000604_amyloidosis1.25916874
61MP0004811_abnormal_neuron_physiology1.25641339
62MP0003329_amyloid_beta_deposits1.24618707
63MP0002882_abnormal_neuron_morphology1.22766686
64MP0002066_abnormal_motor_capabilities/c1.22110823
65MP0000778_abnormal_nervous_system1.18986442
66MP0004043_abnormal_pH_regulation1.17665870
67MP0002229_neurodegeneration1.17655793
68MP0009780_abnormal_chondrocyte_physiolo1.14464046
69MP0002090_abnormal_vision1.14364408
70MP0001348_abnormal_lacrimal_gland1.13086467
71MP0000955_abnormal_spinal_cord1.12090220
72MP0008872_abnormal_physiological_respon1.06762645
73MP0005253_abnormal_eye_physiology1.05669560
74MP0008260_abnormal_autophagy1.05619889
75MP0004858_abnormal_nervous_system1.04196907
76MP0000751_myopathy1.03485179
77MP0003303_peritoneal_inflammation1.01101149
78MP0002837_dystrophic_cardiac_calcinosis0.99796473
79MP0004147_increased_porphyrin_level0.98910163
80MP0005535_abnormal_body_temperature0.98167568
81MP0000747_muscle_weakness0.96010089
82MP0001986_abnormal_taste_sensitivity0.94889897
83MP0002069_abnormal_eating/drinking_beha0.94829737
84MP0003633_abnormal_nervous_system0.93918456
85MP0001765_abnormal_ion_homeostasis0.93161574
86MP0005409_darkened_coat_color0.92864950
87MP0005083_abnormal_biliary_tract0.92574789
88MP0003191_abnormal_cellular_cholesterol0.92183617
89MP0002138_abnormal_hepatobiliary_system0.90093123
90MP0009278_abnormal_bone_marrow0.88031490
91MP0001963_abnormal_hearing_physiology0.87642128
92MP0003632_abnormal_nervous_system0.86230150
93MP0000013_abnormal_adipose_tissue0.83924137
94MP0003631_nervous_system_phenotype0.83362250
95MP0005499_abnormal_olfactory_system0.82223602
96MP0005394_taste/olfaction_phenotype0.82223602
97MP0002752_abnormal_somatic_nervous0.80868044
98MP0003137_abnormal_impulse_conducting0.80741597
99MP0005167_abnormal_blood-brain_barrier0.77097089
100MP0005377_hearing/vestibular/ear_phenot0.76460140
101MP0003878_abnormal_ear_physiology0.76460140
102MP0005166_decreased_susceptibility_to0.74437459
103MP0000631_abnormal_neuroendocrine_gland0.73892122
104MP0002152_abnormal_brain_morphology0.73606321
105MP0001485_abnormal_pinna_reflex0.70908821
106MP0009840_abnormal_foam_cell0.70783930
107MP0002693_abnormal_pancreas_physiology0.69892203
108MP0005084_abnormal_gallbladder_morpholo0.68457091
109MP0004885_abnormal_endolymph0.68293778
110MP0008874_decreased_physiological_sensi0.68139859
111MP0006035_abnormal_mitochondrial_morpho0.67457672
112MP0004742_abnormal_vestibular_system0.66473160
113MP0003172_abnormal_lysosome_physiology0.66441724
114MP0004145_abnormal_muscle_electrophysio0.66099754
115MP0000678_abnormal_parathyroid_gland0.65998333
116MP0005451_abnormal_body_composition0.64385445
117MP0003634_abnormal_glial_cell0.63864294
118MP0002653_abnormal_ependyma_morphology0.63604212
119MP0006036_abnormal_mitochondrial_physio0.63134192
120MP0004085_abnormal_heartbeat0.62294101
121MP0005410_abnormal_fertilization0.62159005
122MP0002277_abnormal_respiratory_mucosa0.61433034
123MP0003121_genomic_imprinting0.61245749
124MP0002751_abnormal_autonomic_nervous0.60614803
125MP0004133_heterotaxia0.60592133
126MP0000681_abnormal_thyroid_gland0.58769689
127MP0001664_abnormal_digestion0.56825249
128MP0002249_abnormal_larynx_morphology0.55931314
129MP0003638_abnormal_response/metabolism_0.54837705
130MP0004036_abnormal_muscle_relaxation0.52301050
131MP0005464_abnormal_platelet_physiology0.51293533

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.13966137
2Febrile seizures (HP:0002373)5.03912506
3Myokymia (HP:0002411)4.88503031
4Focal seizures (HP:0007359)4.80383086
5Atonic seizures (HP:0010819)4.69051475
6* Epileptic encephalopathy (HP:0200134)4.49629440
7Visual hallucinations (HP:0002367)4.30759473
8Absence seizures (HP:0002121)4.23608576
9Dialeptic seizures (HP:0011146)4.17379319
10Congenital stationary night blindness (HP:0007642)4.09943950
11Progressive cerebellar ataxia (HP:0002073)3.63418669
12Generalized tonic-clonic seizures (HP:0002069)3.58642229
13Hyperventilation (HP:0002883)3.48792100
14Neurofibrillary tangles (HP:0002185)3.46313783
15Obstructive sleep apnea (HP:0002870)3.45666199
16Neuronal loss in central nervous system (HP:0002529)3.17863862
17Decreased circulating renin level (HP:0003351)3.14131066
18Ventricular fibrillation (HP:0001663)3.12288657
19Peripheral hypomyelination (HP:0007182)3.06269737
20Mutism (HP:0002300)3.00757031
21Papilledema (HP:0001085)2.92500052
22Gait imbalance (HP:0002141)2.87648398
23Medial flaring of the eyebrow (HP:0010747)2.86702382
24Annular pancreas (HP:0001734)2.82927292
25Cerebral inclusion bodies (HP:0100314)2.82460244
26Bundle branch block (HP:0011710)2.81829018
27Hemiparesis (HP:0001269)2.76428749
28Nephrogenic diabetes insipidus (HP:0009806)2.76223815
29Congenital primary aphakia (HP:0007707)2.75413081
30Torticollis (HP:0000473)2.70654968
31Polyphagia (HP:0002591)2.68978967
32Abnormal hair whorl (HP:0010721)2.68790543
33Cerebral hypomyelination (HP:0006808)2.68667392
34Akinesia (HP:0002304)2.67760983
35Supranuclear gaze palsy (HP:0000605)2.66450117
36Abnormal eating behavior (HP:0100738)2.65883494
37Neuroendocrine neoplasm (HP:0100634)2.55404014
38Failure to thrive in infancy (HP:0001531)2.55236711
39* Epileptiform EEG discharges (HP:0011182)2.54861265
40Pheochromocytoma (HP:0002666)2.50369984
41Intention tremor (HP:0002080)2.49497662
42Clonus (HP:0002169)2.45507761
43Gaze-evoked nystagmus (HP:0000640)2.44860493
44Amblyopia (HP:0000646)2.43317068
45Sleep apnea (HP:0010535)2.41609974
46Abnormality of macular pigmentation (HP:0008002)2.39385854
47Syncope (HP:0001279)2.39303049
48Abnormal mitochondria in muscle tissue (HP:0008316)2.38799366
49Sudden death (HP:0001699)2.38070910
50Anxiety (HP:0000739)2.37220775
51Rapidly progressive (HP:0003678)2.36158143
52Tetraplegia (HP:0002445)2.35143644
53Acute necrotizing encephalopathy (HP:0006965)2.34537730
54Abnormal EKG (HP:0003115)2.30186543
55Urinary urgency (HP:0000012)2.29880684
56Heart block (HP:0012722)2.28966319
57Depression (HP:0000716)2.28813413
58Dysdiadochokinesis (HP:0002075)2.28388652
59Craniofacial dystonia (HP:0012179)2.28338949
60Increased circulating renin level (HP:0000848)2.27371704
61Hyperactive renin-angiotensin system (HP:0000841)2.26253503
62* EEG with generalized epileptiform discharges (HP:0011198)2.25566649
63Abnormal rod and cone electroretinograms (HP:0008323)2.25408353
64Rigidity (HP:0002063)2.25176252
65Distal lower limb muscle weakness (HP:0009053)2.23933972
66Poor coordination (HP:0002370)2.22799922
67Abnormality of the corticospinal tract (HP:0002492)2.21939073
68Hyperthyroidism (HP:0000836)2.21525583
69Truncal ataxia (HP:0002078)2.21289294
70Central scotoma (HP:0000603)2.20969102
71Abnormality of glycolipid metabolism (HP:0010969)2.20386338
72Abnormality of liposaccharide metabolism (HP:0010968)2.20386338
73Abnormality of glycosphingolipid metabolism (HP:0004343)2.20386338
74Lower limb muscle weakness (HP:0007340)2.19763034
75Bradykinesia (HP:0002067)2.15923840
76Broad-based gait (HP:0002136)2.15662053
77Prolonged QT interval (HP:0001657)2.15405984
78Abnormal atrioventricular conduction (HP:0005150)2.14006889
79Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.12321180
80Dysmetria (HP:0001310)2.11561038
81Hemiplegia (HP:0002301)2.11124381
82Unsteady gait (HP:0002317)2.10735461
83Cortical visual impairment (HP:0100704)2.10575014
84Amyloidosis (HP:0011034)2.07676703
85Ankle clonus (HP:0011448)2.04729287
86Growth hormone excess (HP:0000845)2.04153048
87Foot dorsiflexor weakness (HP:0009027)2.04132538
88Hyporeflexia of lower limbs (HP:0002600)2.04103355
89Delusions (HP:0000746)2.03443402
90Apathy (HP:0000741)2.01261912
91Exercise-induced myalgia (HP:0003738)2.01140968
92Slow saccadic eye movements (HP:0000514)2.00186443
93Muscle fiber splitting (HP:0003555)1.99189483
94Abnormality of the lower motor neuron (HP:0002366)1.98853011
95Myopathic facies (HP:0002058)1.98582487
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98459962
97Lower limb asymmetry (HP:0100559)1.96888696
98Poor suck (HP:0002033)1.95982631
99Diminished motivation (HP:0000745)1.95474034
100Absent speech (HP:0001344)1.95345018
101Fetal akinesia sequence (HP:0001989)1.95212207
102Excessive salivation (HP:0003781)1.94724802
103Drooling (HP:0002307)1.94724802
104Ventricular arrhythmia (HP:0004308)1.93820097
105Abnormality of renin-angiotensin system (HP:0000847)1.93533701
106Hypothermia (HP:0002045)1.93167110
107Poor eye contact (HP:0000817)1.93108139
108Insomnia (HP:0100785)1.92867898
109Dynein arm defect of respiratory motile cilia (HP:0012255)1.92575500
110Absent/shortened dynein arms (HP:0200106)1.92575500
111Anomalous pulmonary venous return (HP:0010772)1.90991672
112Abnormality of the foot musculature (HP:0001436)1.90792384
113Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.90437405
114Mitochondrial inheritance (HP:0001427)1.90407781
115Severe visual impairment (HP:0001141)1.90292622
116Progressive macrocephaly (HP:0004481)1.89169046
117Action tremor (HP:0002345)1.89080836
118Truncus arteriosus (HP:0001660)1.89002701
119Spinal canal stenosis (HP:0003416)1.88349531
120Vaginal atresia (HP:0000148)1.88284883
121Scanning speech (HP:0002168)1.88268665
122Increased cerebral lipofuscin (HP:0011813)1.88002517
123* Hypsarrhythmia (HP:0002521)1.87529728
124Genital tract atresia (HP:0001827)1.87098390
125Lower limb amyotrophy (HP:0007210)1.86709514
126Distal upper limb amyotrophy (HP:0007149)1.85801960
127Upper limb amyotrophy (HP:0009129)1.85801960
128Centrally nucleated skeletal muscle fibers (HP:0003687)1.85425970
129Abnormality of saccadic eye movements (HP:0000570)1.84080991
130Postural instability (HP:0002172)1.83982913
131Pancreatic fibrosis (HP:0100732)1.83801786
132Urinary incontinence (HP:0000020)1.83329091
133Impaired vibration sensation in the lower limbs (HP:0002166)1.82800302
134Stereotypic behavior (HP:0000733)1.82671315
135Genetic anticipation (HP:0003743)1.82616817
136Decreased central vision (HP:0007663)1.82399397
137Impaired smooth pursuit (HP:0007772)1.81536502
138Limb dystonia (HP:0002451)1.81312201
139Asymmetric septal hypertrophy (HP:0001670)1.79284255
140Bony spicule pigmentary retinopathy (HP:0007737)1.78550586
141Impaired social interactions (HP:0000735)1.78470174
142Abnormal social behavior (HP:0012433)1.78470174
143Degeneration of the lateral corticospinal tracts (HP:0002314)1.78065128
144Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78065128
145Generalized myoclonic seizures (HP:0002123)1.77947100
146Hyperaldosteronism (HP:0000859)1.77815731
147Spastic tetraparesis (HP:0001285)1.77595918
148Abnormality of binocular vision (HP:0011514)1.77406595
149Diplopia (HP:0000651)1.77406595
150Specific learning disability (HP:0001328)1.75165534
151Urinary bladder sphincter dysfunction (HP:0002839)1.75089502
152Status epilepticus (HP:0002133)1.72825021
153Abnormality of calcium-phosphate metabolism (HP:0100530)1.71946342
154Psychosis (HP:0000709)1.70902853
155Optic disc pallor (HP:0000543)1.70583089
156Increased IgM level (HP:0003496)1.68215583
157Acute encephalopathy (HP:0006846)1.68182060
158Split foot (HP:0001839)1.67747327
159Hyperphosphatemia (HP:0002905)1.67430489
160Focal dystonia (HP:0004373)1.67387058
161Spastic gait (HP:0002064)1.67290237
162Dysautonomia (HP:0002459)1.67235752
163Inability to walk (HP:0002540)1.66546336
164Incomplete penetrance (HP:0003829)1.66507630
165Molar tooth sign on MRI (HP:0002419)1.65991094
166Abnormality of midbrain morphology (HP:0002418)1.65991094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.71072279
2EPHA43.68324815
3ARAF3.22135142
4PRPF4B2.97941091
5MAP3K122.83460153
6MAP3K92.83215971
7CASK2.78935134
8MAP2K72.70105325
9MAP3K112.49141488
10AKT32.41174890
11MAP3K42.37611367
12TRIB32.17375014
13MINK12.10668081
14MAP3K132.08030960
15NME11.99805664
16BMPR21.97144904
17SIK31.89948413
18RIPK41.85154659
19MARK21.84214883
20DAPK11.82778225
21BRAF1.82547303
22DAPK21.68466119
23MARK11.54431562
24RIPK11.54315188
25GRK51.51625299
26MAP2K41.45358406
27PAK61.45244439
28TAOK11.44015967
29PLK21.43725955
30KSR21.43420337
31BCR1.43143735
32INSRR1.37966699
33MAPK121.37964527
34KSR11.37685414
35MAPK131.37080228
36FES1.31762131
37CDK191.31517792
38TNIK1.31159421
39SIK11.28134574
40TESK11.26417352
41PDPK11.20723814
42PRKD31.18019402
43PRKCG1.17205128
44WNK31.14757586
45SGK2231.14383525
46SGK4941.14383525
47TSSK61.13126712
48PTK2B1.10350029
49STK161.09405414
50CDK51.09297824
51SGK21.09104974
52PDK11.03575914
53CCNB11.02409254
54CAMKK21.02165236
55PRKCH1.00813261
56PNCK1.00411155
57ERN11.00308524
58GRK60.99483876
59MAP2K30.98298340
60STK380.98106945
61CAMK2B0.97398706
62CAMK2A0.96895802
63OXSR10.94120800
64NTRK20.92297600
65PRKD20.90544172
66RAF10.90343627
67LIMK10.80047356
68DYRK1B0.79756023
69PRKCE0.79466286
70CDK30.78972512
71ICK0.78735797
72PINK10.78023041
73CDK180.77992955
74TYRO30.77873384
75DYRK1A0.77770278
76GRK70.73013898
77CAMKK10.72546350
78CAMK2D0.69877254
79DAPK30.69237994
80CDK150.68676286
81PKN10.67796928
82ALK0.66781084
83CDK140.66776074
84PRKG20.65777305
85CAMK10.64783058
86NTRK10.63843810
87ERBB30.63680416
88SGK30.63395339
89PRKD10.63039982
90PAK30.61736101
91ADRBK20.61727291
92CAMK2G0.61078358
93FER0.60203149
94RET0.58641178
95CAMK40.58514754
96CDK11A0.57891525
97FYN0.57755568
98MAP3K140.57597860
99MUSK0.57207149
100SGK10.56542794
101TNK20.56291153
102CDC42BPA0.55639579
103MAP3K60.54304013
104MAP3K10.53921320
105MAP2K20.52496788
106IRAK10.52476019
107BMX0.51617882
108STK38L0.51503753
109PRKCZ0.51320830
110TESK20.51159447
111RPS6KC10.50814928
112RPS6KL10.50814928
113DMPK0.50657785
114IRAK20.48558774
115TAOK20.48481712
116MAP2K60.47719100
117MAP3K30.47466769
118MAPK100.46518462
119FGR0.46426211
120NEK10.45396651
121MAPK40.44902589
122LMTK20.42512320
123ADRBK10.42150207
124IRAK40.41788293
125MAP2K10.39365217
126PHKG10.39090232
127PHKG20.39090232
128WNK40.38123657
129NEK60.37978238
130UHMK10.37947528
131MAPK150.37540916
132IRAK30.37052274
133MAP3K20.36551222
134SIK20.36453324
135SYK0.35180503
136RPS6KA20.35115159
137PRKACA0.35092210
138STK110.31603577

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.20025216
2Synaptic vesicle cycle_Homo sapiens_hsa047214.19123508
3Collecting duct acid secretion_Homo sapiens_hsa049663.26815044
4GABAergic synapse_Homo sapiens_hsa047272.87513321
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85998571
6Olfactory transduction_Homo sapiens_hsa047402.74834901
7Circadian entrainment_Homo sapiens_hsa047132.74052742
8Morphine addiction_Homo sapiens_hsa050322.70334205
9Amphetamine addiction_Homo sapiens_hsa050312.29487620
10Glutamatergic synapse_Homo sapiens_hsa047242.27612012
11Long-term potentiation_Homo sapiens_hsa047202.24265443
12Insulin secretion_Homo sapiens_hsa049112.15671116
13Phototransduction_Homo sapiens_hsa047442.13110517
14Vibrio cholerae infection_Homo sapiens_hsa051102.02789660
15Dopaminergic synapse_Homo sapiens_hsa047282.00505977
16Taste transduction_Homo sapiens_hsa047421.99789752
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98937831
18Serotonergic synapse_Homo sapiens_hsa047261.81372554
19Salivary secretion_Homo sapiens_hsa049701.80273769
20Oxidative phosphorylation_Homo sapiens_hsa001901.72434305
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.68561634
22Cholinergic synapse_Homo sapiens_hsa047251.62061264
23Renin secretion_Homo sapiens_hsa049241.56457679
24Calcium signaling pathway_Homo sapiens_hsa040201.45570170
25Cocaine addiction_Homo sapiens_hsa050301.42164935
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39566506
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36807873
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.35757432
29Oxytocin signaling pathway_Homo sapiens_hsa049211.35309527
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32528088
31Long-term depression_Homo sapiens_hsa047301.30990241
32Regulation of autophagy_Homo sapiens_hsa041401.28890335
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25443583
34Type I diabetes mellitus_Homo sapiens_hsa049401.24025763
35Gastric acid secretion_Homo sapiens_hsa049711.23767273
36Cardiac muscle contraction_Homo sapiens_hsa042601.19004035
37Circadian rhythm_Homo sapiens_hsa047101.15787632
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13896795
39Parkinsons disease_Homo sapiens_hsa050121.13345847
40Alzheimers disease_Homo sapiens_hsa050101.11525837
41VEGF signaling pathway_Homo sapiens_hsa043701.09739702
42cAMP signaling pathway_Homo sapiens_hsa040241.09047067
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08986404
44Rheumatoid arthritis_Homo sapiens_hsa053231.08399952
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06138639
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03334342
47Type II diabetes mellitus_Homo sapiens_hsa049301.00082322
48GnRH signaling pathway_Homo sapiens_hsa049120.99238474
49Fructose and mannose metabolism_Homo sapiens_hsa000510.97479241
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96455565
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96097855
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94832629
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92526370
54Histidine metabolism_Homo sapiens_hsa003400.90490273
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90444530
56Huntingtons disease_Homo sapiens_hsa050160.83088321
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81773280
58Bile secretion_Homo sapiens_hsa049760.79457964
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.78375202
60Gap junction_Homo sapiens_hsa045400.74219037
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73424613
62Autoimmune thyroid disease_Homo sapiens_hsa053200.70720251
63Inositol phosphate metabolism_Homo sapiens_hsa005620.70629077
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.70084151
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69181720
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67826182
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67015577
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66344655
69Arginine and proline metabolism_Homo sapiens_hsa003300.64372231
70Proteasome_Homo sapiens_hsa030500.64084716
71Estrogen signaling pathway_Homo sapiens_hsa049150.62825520
72Rap1 signaling pathway_Homo sapiens_hsa040150.60012698
73Pancreatic secretion_Homo sapiens_hsa049720.58176734
74Other glycan degradation_Homo sapiens_hsa005110.56618106
75ErbB signaling pathway_Homo sapiens_hsa040120.56558649
76AMPK signaling pathway_Homo sapiens_hsa041520.55703744
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.55619482
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55258942
79Lysosome_Homo sapiens_hsa041420.54732092
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54605920
81mTOR signaling pathway_Homo sapiens_hsa041500.54517106
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54352716
83Arginine biosynthesis_Homo sapiens_hsa002200.53697399
84MAPK signaling pathway_Homo sapiens_hsa040100.53053351
85Endometrial cancer_Homo sapiens_hsa052130.52308981
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.52147846
87Phagosome_Homo sapiens_hsa041450.51621463
88beta-Alanine metabolism_Homo sapiens_hsa004100.51318394
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49558441
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.48290192
91Allograft rejection_Homo sapiens_hsa053300.46900061
92Notch signaling pathway_Homo sapiens_hsa043300.44339116
93Thyroid hormone synthesis_Homo sapiens_hsa049180.44123884
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42956179
95Chemokine signaling pathway_Homo sapiens_hsa040620.42295901
96Non-small cell lung cancer_Homo sapiens_hsa052230.40019523
97B cell receptor signaling pathway_Homo sapiens_hsa046620.39854106
98Glucagon signaling pathway_Homo sapiens_hsa049220.39615013
99Oocyte meiosis_Homo sapiens_hsa041140.38181868
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37736705
101Vitamin B6 metabolism_Homo sapiens_hsa007500.36919017
102Axon guidance_Homo sapiens_hsa043600.36578201
103Melanogenesis_Homo sapiens_hsa049160.36152077
104Osteoclast differentiation_Homo sapiens_hsa043800.35260748
105Glioma_Homo sapiens_hsa052140.34425400
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.34286560
107Ras signaling pathway_Homo sapiens_hsa040140.32653176
108African trypanosomiasis_Homo sapiens_hsa051430.31785092
109Dilated cardiomyopathy_Homo sapiens_hsa054140.30760240
110Prion diseases_Homo sapiens_hsa050200.29748337
111Choline metabolism in cancer_Homo sapiens_hsa052310.28984659
112Endocytosis_Homo sapiens_hsa041440.26481250
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.24924888
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24310836
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23332567
116Alcoholism_Homo sapiens_hsa050340.21426339
117Galactose metabolism_Homo sapiens_hsa000520.18837826
118Mineral absorption_Homo sapiens_hsa049780.18683909
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18282739
120Tuberculosis_Homo sapiens_hsa051520.18162213
121Graft-versus-host disease_Homo sapiens_hsa053320.17341055
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16805778
123Phenylalanine metabolism_Homo sapiens_hsa003600.15653115
124Insulin signaling pathway_Homo sapiens_hsa049100.14097903
125Protein export_Homo sapiens_hsa030600.13551775
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11659346

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