ROM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of visible light (GO:0009584)9.78932335
2positive regulation of guanylate cyclase activity (GO:0031284)9.74177609
3regulation of guanylate cyclase activity (GO:0031282)8.81239347
4* visual perception (GO:0007601)8.63740643
5* sensory perception of light stimulus (GO:0050953)8.54728714
6protein-chromophore linkage (GO:0018298)7.95421292
7cellular response to light stimulus (GO:0071482)7.45802715
8detection of external stimulus (GO:0009581)6.99759393
9retina development in camera-type eye (GO:0060041)6.90851004
10detection of abiotic stimulus (GO:0009582)6.86308542
11regulation of cGMP metabolic process (GO:0030823)6.50850061
12positive regulation of cGMP biosynthetic process (GO:0030828)5.89720606
13regulation of cGMP biosynthetic process (GO:0030826)5.54283724
14axon ensheathment in central nervous system (GO:0032291)5.22635271
15central nervous system myelination (GO:0022010)5.22635271
16positive regulation of cGMP metabolic process (GO:0030825)5.19186929
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.13672812
18receptor guanylyl cyclase signaling pathway (GO:0007168)5.00321646
19nonmotile primary cilium assembly (GO:0035058)4.97579446
20positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.91597099
21cell morphogenesis involved in neuron differentiation (GO:0048667)4.78576083
22cellular response to radiation (GO:0071478)4.78075582
23detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.60431645
24astrocyte development (GO:0014002)4.57427260
25glutamate secretion (GO:0014047)4.56698980
26synaptic vesicle exocytosis (GO:0016079)4.56579854
27cellular response to electrical stimulus (GO:0071257)4.54252326
28vitamin A metabolic process (GO:0006776)4.44749755
29adaptation of signaling pathway (GO:0023058)4.29118204
30regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.23838838
31regulation of voltage-gated calcium channel activity (GO:1901385)4.23744715
32regulation of clathrin-mediated endocytosis (GO:2000369)4.10713978
33* sensory perception (GO:0007600)4.03031762
34postsynaptic membrane organization (GO:0001941)4.02664238
35response to parathyroid hormone (GO:0071107)4.01541120
36L-amino acid import (GO:0043092)3.97852774
37protein prenylation (GO:0018342)3.93413382
38prenylation (GO:0097354)3.93413382
39negative regulation of catenin import into nucleus (GO:0035414)3.87567451
40response to light stimulus (GO:0009416)3.86643860
41astrocyte differentiation (GO:0048708)3.85416380
42neuron development (GO:0048666)3.82362301
43peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.79600964
44retina homeostasis (GO:0001895)3.70655009
45positive regulation of synapse maturation (GO:0090129)3.65416054
46adenosine receptor signaling pathway (GO:0001973)3.63787153
47retina layer formation (GO:0010842)3.55634363
48positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.55230789
49amino acid import (GO:0043090)3.52450368
50neuronal ion channel clustering (GO:0045161)3.50188598
51negative regulation of receptor-mediated endocytosis (GO:0048261)3.49823475
52estrogen biosynthetic process (GO:0006703)3.49416107
53regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.46031524
54regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.46031524
55short-term memory (GO:0007614)3.41744960
56regulation of synaptic vesicle exocytosis (GO:2000300)3.41243314
57cellular response to nitric oxide (GO:0071732)3.38975074
58protein localization to synapse (GO:0035418)3.38704229
59positive regulation of sodium ion transmembrane transport (GO:1902307)3.35494092
60positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.34374865
61* photoreceptor cell differentiation (GO:0046530)3.33913522
62* eye photoreceptor cell differentiation (GO:0001754)3.33913522
63behavioral response to ethanol (GO:0048149)3.32562773
64regulation of penile erection (GO:0060405)3.31347999
65potassium ion import (GO:0010107)3.30782451
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.19478305
67chemosensory behavior (GO:0007635)3.17491759
68regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.17309097
69positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.12803023
70response to histamine (GO:0034776)3.10757576
71cellular sodium ion homeostasis (GO:0006883)3.10016265
72locomotory exploration behavior (GO:0035641)3.09922401
73regulation of neuronal synaptic plasticity (GO:0048168)3.07913640
74regulation of short-term neuronal synaptic plasticity (GO:0048172)3.07081769
75regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00559323
76neurotransmitter secretion (GO:0007269)3.00392606
77acidic amino acid transport (GO:0015800)3.00140628
78cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.98396575
79detection of temperature stimulus involved in sensory perception (GO:0050961)2.97566739
80detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.97566739
81myelin maintenance (GO:0043217)2.97474185
82cerebellar granule cell differentiation (GO:0021707)2.97036474
83membrane hyperpolarization (GO:0060081)2.95815128
84regulation of synaptic vesicle transport (GO:1902803)2.94985219
85negative regulation of telomerase activity (GO:0051974)2.94418743
86positive regulation of neurotransmitter transport (GO:0051590)2.90681404
87CDP-diacylglycerol biosynthetic process (GO:0016024)2.90514545
88regulation of response to food (GO:0032095)2.89696299
89regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.88580674
90cerebellar Purkinje cell layer development (GO:0021680)2.87224514
91cellular potassium ion homeostasis (GO:0030007)2.85681063
92negative regulation of DNA biosynthetic process (GO:2000279)2.85074415
93regulation of synapse structural plasticity (GO:0051823)2.84861874
94L-glutamate transport (GO:0015813)2.83273331
95cellular response to cadmium ion (GO:0071276)2.81356616
96epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.80613653
97peptidyl-tyrosine autophosphorylation (GO:0038083)2.79001409
98regulation of synaptic plasticity (GO:0048167)2.78546300
99negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78347910
100white fat cell differentiation (GO:0050872)2.77916239
101regulation of cholesterol biosynthetic process (GO:0045540)2.77325221
102negative regulation of calcium ion transmembrane transport (GO:1903170)2.75834455
103negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.75834455
104response to leptin (GO:0044321)2.75230991
105arachidonic acid secretion (GO:0050482)2.74712499
106icosanoid secretion (GO:0032309)2.74712499
107gamma-aminobutyric acid signaling pathway (GO:0007214)2.74654791
108synaptic vesicle maturation (GO:0016188)2.74542175
109retinoid metabolic process (GO:0001523)2.73568221
110CDP-diacylglycerol metabolic process (GO:0046341)2.73121516
111axoneme assembly (GO:0035082)2.72221128
112negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.72159680
113ionotropic glutamate receptor signaling pathway (GO:0035235)2.71582305
114negative regulation of cation channel activity (GO:2001258)2.71449038
115regulation of sensory perception (GO:0051931)2.69842925
116regulation of sensory perception of pain (GO:0051930)2.69842925
117protein heterotetramerization (GO:0051290)2.69793171
118regulation of hydrogen peroxide-induced cell death (GO:1903205)2.68987787
119neuronal action potential propagation (GO:0019227)2.68380403
120regulation of synapse maturation (GO:0090128)2.67281064
121response to radiation (GO:0009314)2.64656527
122axon ensheathment (GO:0008366)2.64639557
123ensheathment of neurons (GO:0007272)2.64639557
124positive regulation of protein dephosphorylation (GO:0035307)2.64530396
125neuron projection regeneration (GO:0031102)2.63809099
126cell migration involved in heart development (GO:0060973)2.61897597
127sodium ion export (GO:0071436)2.61297243
128regulation of plasminogen activation (GO:0010755)2.61269017
129behavioral fear response (GO:0001662)2.60946181
130behavioral defense response (GO:0002209)2.60946181
131positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.60662338
132lipid translocation (GO:0034204)2.60495779
133phospholipid translocation (GO:0045332)2.60495779
134regulation of respiratory system process (GO:0044065)2.60411997
135regulation of long-term neuronal synaptic plasticity (GO:0048169)2.59803263
136myelination (GO:0042552)2.58752702
137lipoprotein transport (GO:0042953)2.58033628
138retinol metabolic process (GO:0042572)2.57661516
139positive regulation of extracellular matrix organization (GO:1903055)2.57063852
140long-term synaptic potentiation (GO:0060291)2.56950706
141positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.56619081
142detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.56429705
143dopamine receptor signaling pathway (GO:0007212)2.56370832
144behavioral response to cocaine (GO:0048148)2.56283312
145neuron cell-cell adhesion (GO:0007158)2.55942875
146detection of temperature stimulus (GO:0016048)2.55322553
147neuromuscular process controlling balance (GO:0050885)2.53862520
148synaptic transmission, dopaminergic (GO:0001963)2.53825414
149diterpenoid metabolic process (GO:0016101)2.52574807
150detection of chemical stimulus involved in sensory perception (GO:0050907)2.52009896
151dicarboxylic acid transport (GO:0006835)2.51480774
152negative regulation of transcription regulatory region DNA binding (GO:2000678)2.49966973
153layer formation in cerebral cortex (GO:0021819)2.48451337
154cellular response to reactive nitrogen species (GO:1902170)2.48228220
155potassium ion homeostasis (GO:0055075)2.48065715
156exploration behavior (GO:0035640)2.47547123
157response to pheromone (GO:0019236)2.47384397
158one-carbon compound transport (GO:0019755)2.45885183
159positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.45645382
160cell communication by electrical coupling (GO:0010644)2.44900151
161neurotransmitter-gated ion channel clustering (GO:0072578)2.43940297
162barbed-end actin filament capping (GO:0051016)2.42882790
163substantia nigra development (GO:0021762)2.41118548
164positive regulation of dendritic spine development (GO:0060999)2.40835964
165neuromuscular process controlling posture (GO:0050884)2.40534987
166cellular response to abiotic stimulus (GO:0071214)2.40211816
167positive regulation of cyclase activity (GO:0031281)2.40071793
168regulation of neurotransmitter uptake (GO:0051580)2.38341914
169positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.37743643
170terpenoid metabolic process (GO:0006721)2.30670622
171positive regulation of membrane potential (GO:0045838)2.28652942
172synaptic vesicle docking involved in exocytosis (GO:0016081)2.28018030
173regulation of rhodopsin mediated signaling pathway (GO:0022400)17.9498341
174rhodopsin mediated signaling pathway (GO:0016056)17.4857110
175retinal cone cell development (GO:0046549)15.1575151
176photoreceptor cell development (GO:0042461)12.8359172
177eye photoreceptor cell development (GO:0042462)12.2381878
178photoreceptor cell maintenance (GO:0045494)12.0980137
179detection of light stimulus involved in sensory perception (GO:0050962)11.2269737
180detection of light stimulus involved in visual perception (GO:0050908)11.2269737
181retinal rod cell development (GO:0046548)10.7319662
182phototransduction (GO:0007602)10.4520318
183GMP metabolic process (GO:0046037)10.4154231
184phototransduction, visible light (GO:0007603)10.1574291
185detection of light stimulus (GO:0009583)10.0154037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.78666457
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.48869619
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse4.25896688
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.90833838
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.39827491
6VDR_22108803_ChIP-Seq_LS180_Human3.39734033
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.03319695
8DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.94324218
9EZH2_22144423_ChIP-Seq_EOC_Human2.71018569
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.41196204
11DROSHA_22980978_ChIP-Seq_HELA_Human2.31447094
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23216511
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.14194714
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13635907
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.11840471
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.09077373
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.06723169
18KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89311300
19BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.87260220
20GBX2_23144817_ChIP-Seq_PC3_Human1.86345736
21KDM2B_26808549_Chip-Seq_K562_Human1.82764474
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81807278
23SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.81658271
24SMAD3_21741376_ChIP-Seq_HESCs_Human1.77940342
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.77590419
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74279086
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.72254202
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.71230810
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67939817
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65594925
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65248532
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.60962121
33* REST_18959480_ChIP-ChIP_MESCs_Mouse1.60818463
34REST_21632747_ChIP-Seq_MESCs_Mouse1.60661641
35SMC4_20622854_ChIP-Seq_HELA_Human1.60030669
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59473213
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57412020
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56422332
39CTCF_27219007_Chip-Seq_Bcells_Human1.56401510
40SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55947928
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55425914
42GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53195410
43TP53_20018659_ChIP-ChIP_R1E_Mouse1.51896212
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51625281
45P53_22127205_ChIP-Seq_FIBROBLAST_Human1.51386158
46NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.51223343
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50236323
48AR_19668381_ChIP-Seq_PC3_Human1.48070158
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47471865
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46837049
51AR_21572438_ChIP-Seq_LNCaP_Human1.45082883
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44649901
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.43219816
54RACK7_27058665_Chip-Seq_MCF-7_Human1.41309464
55* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40528937
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.39268667
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.36802496
58TCF4_18268006_ChIP-ChIP_LS174T_Human1.35338272
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.34846526
60STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.34254135
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34009395
62TET1_21490601_ChIP-Seq_MESCs_Mouse1.33347509
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32892896
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32409023
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30974435
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30974435
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30711477
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29404808
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28975529
70ZNF263_19887448_ChIP-Seq_K562_Human1.28632033
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.28343902
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27999069
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.27965423
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27901443
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27885315
76CTCF_20526341_ChIP-Seq_ESCs_Human1.27135632
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.26182603
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25709030
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25325468
80CREB1_26743006_Chip-Seq_LNCaP_Human1.23952155
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.23901544
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23519339
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22976296
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22813485
85ELK4_26923725_Chip-Seq_MESODERM_Mouse1.22768433
86MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.22750218
87WDR5_24793694_ChIP-Seq_LNCAP_Human1.22479104
88* P68_20966046_ChIP-Seq_HELA_Human1.17645416
89TBL1_22424771_ChIP-Seq_293T_Human1.15439939
90SA1_27219007_Chip-Seq_Bcells_Human1.13630988
91BCAT_22108803_ChIP-Seq_LS180_Human1.12895854
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12514217
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12410933
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12236161
95* TAF2_19829295_ChIP-Seq_ESCs_Human1.11278147
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10158968
97NCOR_22424771_ChIP-Seq_293T_Human1.10119929
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09049734
99LXR_22292898_ChIP-Seq_THP-1_Human1.07128694
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06875666
101DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06630764
102EZH2_27304074_Chip-Seq_ESCs_Mouse1.06230513
103VDR_21846776_ChIP-Seq_THP-1_Human1.05925529
104SMAD4_21799915_ChIP-Seq_A2780_Human1.05688907
105CBP_21632823_ChIP-Seq_H3396_Human1.04539849
106SMAD4_21741376_ChIP-Seq_ESCs_Human1.04130015
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04009868
108ERG_20517297_ChIP-Seq_VCAP_Human1.03717668
109SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03556035
110EGR1_19032775_ChIP-ChIP_M12_Human1.03427734
111HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02395551
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02393363
113SMAD4_21741376_ChIP-Seq_HESCs_Human1.01285898
114BCOR_27268052_Chip-Seq_Bcells_Human1.00973818
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00136102
116KDM2B_26808549_Chip-Seq_DND41_Human0.99519227
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99355103
118DPY_21335234_ChIP-Seq_ESCs_Mouse0.99143566
119ISL1_27105846_Chip-Seq_CPCs_Mouse0.99094310
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98514056
121IGF1R_20145208_ChIP-Seq_DFB_Human0.98428293
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97816370
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97686530
124* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97068473
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96874877
126SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96254994
127TP63_22573176_ChIP-Seq_HFKS_Human0.96077057
128PRDM14_20953172_ChIP-Seq_ESCs_Human0.95317080
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95301403
130JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94580098
131DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94375071
132GATA1_26923725_Chip-Seq_HPCs_Mouse0.93950725
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93479878
134STAT3_23295773_ChIP-Seq_U87_Human0.92832967
135SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92412429
136P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.91639746
137FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91326618
138* GATA1_19941827_ChIP-Seq_MEL_Mouse0.90419416
139CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90357137
140VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89909461
141EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89883368
142FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89863076
143* OCT4_19829295_ChIP-Seq_ESCs_Human0.89365117
144SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.89308538
145GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88717811
146RING1B_27294783_Chip-Seq_ESCs_Mouse0.88663547
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88658664
148P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88657587
149RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87424310
150SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87323323
151YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87185774
152OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85231582
153WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83070564
154TP53_23651856_ChIP-Seq_MEFs_Mouse0.83002025
155JARID2_20064375_ChIP-Seq_MESCs_Mouse0.82339463
156GF1_26923725_Chip-Seq_HPCs_Mouse0.82314521
157GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81809427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.69028478
2MP0005253_abnormal_eye_physiology6.94731505
3MP0006072_abnormal_retinal_apoptosis6.72151913
4MP0003950_abnormal_plasma_membrane4.10005196
5* MP0005195_abnormal_posterior_eye3.90058611
6MP0001324_abnormal_eye_pigmentation3.54224575
7MP0005391_vision/eye_phenotype3.38803274
8MP0002638_abnormal_pupillary_reflex3.13480252
9MP0002090_abnormal_vision2.86896474
10MP0003329_amyloid_beta_deposits2.70330817
11MP0003690_abnormal_glial_cell2.69846183
12MP0002229_neurodegeneration2.59430348
13MP0005423_abnormal_somatic_nervous2.58355917
14MP0000920_abnormal_myelination2.50477404
15MP0005167_abnormal_blood-brain_barrier2.31577364
16MP0003705_abnormal_hypodermis_morpholog2.23201754
17MP0001986_abnormal_taste_sensitivity2.23199543
18MP0001764_abnormal_homeostasis2.04851948
19MP0003011_delayed_dark_adaptation10.4442165
20MP0005670_abnormal_white_adipose1.96621459
21MP0002752_abnormal_somatic_nervous1.96338965
22MP0003879_abnormal_hair_cell1.95643281
23MP0002736_abnormal_nociception_after1.80635235
24MP0005058_abnormal_lysosome_morphology1.78897370
25MP0002735_abnormal_chemical_nociception1.77628814
26MP0005646_abnormal_pituitary_gland1.74873354
27MP0002653_abnormal_ependyma_morphology1.64322206
28MP0000604_amyloidosis1.60626192
29MP0003075_altered_response_to1.60619647
30MP0001970_abnormal_pain_threshold1.55659607
31MP0003631_nervous_system_phenotype1.51678104
32MP0001905_abnormal_dopamine_level1.48437325
33MP0002882_abnormal_neuron_morphology1.39268701
34MP0002733_abnormal_thermal_nociception1.35423843
35MP0001502_abnormal_circadian_rhythm1.35072700
36MP0009840_abnormal_foam_cell1.31958434
37MP0003123_paternal_imprinting1.27758843
38MP0005623_abnormal_meninges_morphology1.27373166
39MP0001984_abnormal_olfaction1.25237971
40MP0004233_abnormal_muscle_weight1.22805510
41MP0001346_abnormal_lacrimal_gland1.19172427
42MP0000566_synostosis1.15785645
43MP0002295_abnormal_pulmonary_circulatio1.14121312
44MP0004019_abnormal_vitamin_homeostasis1.12455306
45MP0003183_abnormal_peptide_metabolism1.11452693
46MP0000778_abnormal_nervous_system1.11122277
47MP0005377_hearing/vestibular/ear_phenot1.06987724
48MP0003878_abnormal_ear_physiology1.06987724
49MP0005197_abnormal_uvea_morphology1.06730178
50MP0001440_abnormal_grooming_behavior1.06174444
51MP0004885_abnormal_endolymph1.04295323
52MP0001501_abnormal_sleep_pattern1.01747555
53MP0002249_abnormal_larynx_morphology1.01515683
54MP0004185_abnormal_adipocyte_glucose1.01450332
55MP0002127_abnormal_cardiovascular_syste0.98776057
56MP0005499_abnormal_olfactory_system0.98186244
57MP0005394_taste/olfaction_phenotype0.98186244
58MP0000747_muscle_weakness0.97054620
59MP0008874_decreased_physiological_sensi0.95698791
60MP0006292_abnormal_olfactory_placode0.92233681
61MP0000955_abnormal_spinal_cord0.91818734
62MP0005187_abnormal_penis_morphology0.91485484
63MP0002332_abnormal_exercise_endurance0.91244297
64MP0008789_abnormal_olfactory_epithelium0.90024040
65MP0005171_absent_coat_pigmentation0.88336353
66MP0003634_abnormal_glial_cell0.85159394
67MP0001958_emphysema0.84989720
68MP0002557_abnormal_social/conspecific_i0.82480468
69MP0002877_abnormal_melanocyte_morpholog0.81348665
70MP0000534_abnormal_ureter_morphology0.79886262
71MP0002272_abnormal_nervous_system0.75905730
72MP0004270_analgesia0.72616195
73MP0005166_decreased_susceptibility_to0.68821619
74MP0001486_abnormal_startle_reflex0.66267638
75MP0009250_abnormal_appendicular_skeleto0.64110247
76MP0004147_increased_porphyrin_level0.62696581
77MP0001177_atelectasis0.61162151
78MP0004215_abnormal_myocardial_fiber0.61109960
79MP0000762_abnormal_tongue_morphology0.60567067
80MP0003191_abnormal_cellular_cholesterol0.60230030
81MP0000681_abnormal_thyroid_gland0.60098903
82MP0001348_abnormal_lacrimal_gland0.59313919
83MP0005666_abnormal_adipose_tissue0.58714144
84MP0005535_abnormal_body_temperature0.57100044
85MP0002734_abnormal_mechanical_nocicepti0.54025710
86MP0003279_aneurysm0.53988357
87MP0001286_abnormal_eye_development0.53129102
88MP0005503_abnormal_tendon_morphology0.52653954
89MP0004145_abnormal_muscle_electrophysio0.50218044
90MP0003880_abnormal_central_pattern0.49548949
91MP0003646_muscle_fatigue0.46510824
92MP0002064_seizures0.46205502
93MP0000751_myopathy0.45508986
94MP0005376_homeostasis/metabolism_phenot0.45345454
95MP0009046_muscle_twitch0.45051247
96MP0004782_abnormal_surfactant_physiolog0.44839749
97MP0003635_abnormal_synaptic_transmissio0.43099817
98MP0001963_abnormal_hearing_physiology0.42790398
99MP0005620_abnormal_muscle_contractility0.42252594
100MP0004859_abnormal_synaptic_plasticity0.41236453
101MP0002067_abnormal_sensory_capabilities0.41206961
102MP0003045_fibrosis0.40456608
103MP0000465_gastrointestinal_hemorrhage0.40442523
104MP0004085_abnormal_heartbeat0.39869234
105MP0010386_abnormal_urinary_bladder0.39493051
106MP0005248_abnormal_Harderian_gland0.39225363
107MP0004036_abnormal_muscle_relaxation0.38324138
108MP0004043_abnormal_pH_regulation0.37900515
109MP0004084_abnormal_cardiac_muscle0.36741524
110MP0005595_abnormal_vascular_smooth0.35024302
111MP0002063_abnormal_learning/memory/cond0.33721654
112MP0002697_abnormal_eye_size0.33685975
113MP0000631_abnormal_neuroendocrine_gland0.31161041
114MP0005386_behavior/neurological_phenoty0.30278778
115MP0004924_abnormal_behavior0.30278778
116MP0002572_abnormal_emotion/affect_behav0.29334949
117MP0005193_abnormal_anterior_eye0.28743576
118MP0002234_abnormal_pharynx_morphology0.28276176
119MP0005076_abnormal_cell_differentiation0.27439112
120MP0010030_abnormal_orbit_morphology0.27403618
121MP0009745_abnormal_behavioral_response0.26064484
122MP0008569_lethality_at_weaning0.25893279
123MP0005330_cardiomyopathy0.25407382
124MP0008775_abnormal_heart_ventricle0.24350913
125MP0004142_abnormal_muscle_tone0.24305688
126MP0002184_abnormal_innervation0.24052006
127MP0000749_muscle_degeneration0.23214285
128MP0004811_abnormal_neuron_physiology0.22498584
129MP0001968_abnormal_touch/_nociception0.22463784
130MP0001661_extended_life_span0.22049652
131MP0000026_abnormal_inner_ear0.21522465
132MP0003890_abnormal_embryonic-extraembry0.21431092
133MP0002152_abnormal_brain_morphology0.21029651
134MP0002108_abnormal_muscle_morphology0.20635402
135MP0002066_abnormal_motor_capabilities/c0.19964466
136MP0003252_abnormal_bile_duct0.19816677
137MP0004742_abnormal_vestibular_system0.19539009
138MP0001915_intracranial_hemorrhage0.19232514
139MP0002909_abnormal_adrenal_gland0.19113758
140MP0009780_abnormal_chondrocyte_physiolo0.18600390
141MP0003633_abnormal_nervous_system0.17249407
142MP0000230_abnormal_systemic_arterial0.17123404
143MP0008961_abnormal_basal_metabolism0.16998075
144MP0002928_abnormal_bile_duct0.16644195
145MP0003137_abnormal_impulse_conducting0.16506813
146MP0003638_abnormal_response/metabolism_0.16050483
147MP0008004_abnormal_stomach_pH0.15174794
148MP0002972_abnormal_cardiac_muscle0.14054699
149MP0003632_abnormal_nervous_system0.14004740
150MP0004130_abnormal_muscle_cell0.13368883
151MP0010368_abnormal_lymphatic_system0.13264545

Predicted human phenotypes

RankGene SetZ-score
1Chorioretinal atrophy (HP:0000533)9.34658809
2Central scotoma (HP:0000603)8.31757439
3Pendular nystagmus (HP:0012043)8.07704251
4* Pigmentary retinal degeneration (HP:0001146)7.70035172
5Attenuation of retinal blood vessels (HP:0007843)7.45193604
6Abnormality of macular pigmentation (HP:0008002)7.34379866
7Dyschromatopsia (HP:0007641)7.33603206
8Scotoma (HP:0000575)7.30831839
9Abolished electroretinogram (ERG) (HP:0000550)7.11760755
10Decreased central vision (HP:0007663)6.41577954
11* Type II diabetes mellitus (HP:0005978)5.62907056
12Action tremor (HP:0002345)5.54397856
13* Photophobia (HP:0000613)5.45752849
14Keratoconus (HP:0000563)5.30694672
15Increased corneal curvature (HP:0100692)5.30694672
16Vitreoretinal degeneration (HP:0000655)5.20375130
17Macular degeneration (HP:0000608)5.11431749
18Posterior subcapsular cataract (HP:0007787)4.98097620
19Severe visual impairment (HP:0001141)4.97453002
20Cone-rod dystrophy (HP:0000548)4.82296597
21Constricted visual fields (HP:0001133)4.44205402
22Myokymia (HP:0002411)4.39961515
23Choroideremia (HP:0001139)4.25643563
24Peripheral hypomyelination (HP:0007182)4.20459013
25* Retinitis pigmentosa (HP:0000510)4.17382450
26Neurofibrillary tangles (HP:0002185)4.05272588
27Abnormality of binocular vision (HP:0011514)4.00395184
28Diplopia (HP:0000651)4.00395184
29Decreased electroretinogram (ERG) amplitude (HP:0000654)3.61603936
30Ankle clonus (HP:0011448)3.52548582
31Supranuclear gaze palsy (HP:0000605)3.47513984
32Progressive visual loss (HP:0000529)3.17809746
33Annular pancreas (HP:0001734)3.13754810
34Cerebral inclusion bodies (HP:0100314)2.99819157
35Subcapsular cataract (HP:0000523)2.98057388
36Turricephaly (HP:0000262)2.85274337
37Aplasia involving bones of the upper limbs (HP:0009823)2.83046155
38Aplasia of the phalanges of the hand (HP:0009802)2.83046155
39Aplasia involving bones of the extremities (HP:0009825)2.83046155
40Insomnia (HP:0100785)2.82065546
41Obstructive sleep apnea (HP:0002870)2.75847131
42Retinal atrophy (HP:0001105)2.74839544
43Systemic lupus erythematosus (HP:0002725)2.72382758
44Optic disc pallor (HP:0000543)2.66870237
45Intention tremor (HP:0002080)2.61043992
46Focal motor seizures (HP:0011153)2.58997188
47Spastic gait (HP:0002064)2.58537762
48Cerebral hypomyelination (HP:0006808)2.58082489
49Gait imbalance (HP:0002141)2.52003997
50Vertebral compression fractures (HP:0002953)2.51979713
51Congenital primary aphakia (HP:0007707)2.50194198
52* Wide nasal bridge (HP:0000431)2.48598245
53Ulnar claw (HP:0001178)2.46129474
54Dysmetria (HP:0001310)2.44744652
55Hemiparesis (HP:0001269)2.41449616
56Axonal loss (HP:0003447)2.37194410
57Protrusio acetabuli (HP:0003179)2.29138409
58Heterochromia iridis (HP:0001100)2.26487309
59Nuclear cataract (HP:0100018)2.25202196
60Akinesia (HP:0002304)2.24871362
61Nephrogenic diabetes insipidus (HP:0009806)2.21463426
62Hyperparathyroidism (HP:0000843)2.18580780
63Rigidity (HP:0002063)2.18349787
64Scanning speech (HP:0002168)2.17451603
65Congenital sensorineural hearing impairment (HP:0008527)2.16591664
66Focal seizures (HP:0007359)2.14409941
67Medial flaring of the eyebrow (HP:0010747)2.11779692
68Biconcave vertebral bodies (HP:0004586)2.10509363
69Foot dorsiflexor weakness (HP:0009027)2.09715617
70Persistence of primary teeth (HP:0006335)2.06664312
71Abnormal eating behavior (HP:0100738)2.04384403
72Athetosis (HP:0002305)2.02606541
73Congenital stationary night blindness (HP:0007642)15.2999712
74Bony spicule pigmentary retinopathy (HP:0007737)11.6030633
75Absent rod-and cone-mediated responses on ERG (HP:0007688)10.9818012
76Abnormal rod and cone electroretinograms (HP:0008323)10.7739693
77Clonus (HP:0002169)1.96145261
78Spinal canal stenosis (HP:0003416)1.95783363
79Congenital glaucoma (HP:0001087)1.94845030
80Abnormality of the phalanges of the hallux (HP:0010057)1.91955588
81Hyporeflexia of lower limbs (HP:0002600)1.91650743
82Rapidly progressive (HP:0003678)1.91066601
83Poor coordination (HP:0002370)1.90381499
84White forelock (HP:0002211)1.89858502
85Torticollis (HP:0000473)1.89236496
86Increased CSF protein (HP:0002922)1.87757074
87Anxiety (HP:0000739)1.86617239
88Dementia (HP:0000726)1.86566306
89Slow saccadic eye movements (HP:0000514)1.86442442
90Visceral angiomatosis (HP:0100761)1.81441494
91Amyloidosis (HP:0011034)1.80057444
92Papilledema (HP:0001085)1.79542891
93Esophageal varix (HP:0002040)1.78423632
94Glomerulonephritis (HP:0000099)1.77847465
95Atonic seizures (HP:0010819)1.77739635
96Ulnar bowing (HP:0003031)1.77638132
97Poor speech (HP:0002465)1.77586591
98Increased circulating renin level (HP:0000848)1.77542454
99Postural tremor (HP:0002174)1.76903537
100Megalencephaly (HP:0001355)1.76487255
101Abnormality of the foot musculature (HP:0001436)1.76031220
102Urinary incontinence (HP:0000020)1.75886263
103Choreoathetosis (HP:0001266)1.75578772
104Buphthalmos (HP:0000557)1.75188892
105Metaphyseal dysplasia (HP:0100255)1.75180074
106Decreased motor nerve conduction velocity (HP:0003431)1.72041518
107Abnormality of the periventricular white matter (HP:0002518)1.71959607
108Interstitial pulmonary disease (HP:0006530)1.70990246
109Shallow orbits (HP:0000586)1.70940551
110Vaginal atresia (HP:0000148)1.70706665
111Coronal craniosynostosis (HP:0004440)1.70541004
112Postural instability (HP:0002172)1.69781669
113Delusions (HP:0000746)1.69190257
114Complement deficiency (HP:0004431)1.68575813
115Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68253465
116Abnormality of alanine metabolism (HP:0010916)1.68253465
117Hyperalaninemia (HP:0003348)1.68253465
118Broad metatarsal (HP:0001783)1.67820612
119Segmental peripheral demyelination/remyelination (HP:0003481)1.67816469
120Hypoplastic left heart (HP:0004383)1.65985558
121Mitral regurgitation (HP:0001653)1.65146027
122Genital tract atresia (HP:0001827)1.63553117
123Polar cataract (HP:0010696)1.63434105
124* Optic atrophy (HP:0000648)1.62378479
125True hermaphroditism (HP:0010459)1.59882799
126Horizontal nystagmus (HP:0000666)1.43611243
127Severe Myopia (HP:0011003)1.43294056
128Aplasia/Hypoplasia of the lens (HP:0008063)1.43152429
129Pancreatic fibrosis (HP:0100732)1.34073253
130Dysdiadochokinesis (HP:0002075)1.31311228
131Abnormality of the fovea (HP:0000493)1.25369030
132Hypoplasia of the fovea (HP:0007750)1.21301852
133Aplasia/Hypoplasia of the fovea (HP:0008060)1.21301852
134Left ventricular hypertrophy (HP:0001712)1.15501381
135Cystic liver disease (HP:0006706)1.14722100
136Epileptic encephalopathy (HP:0200134)1.12164040
137Astigmatism (HP:0000483)1.10034854
138Cerebellar dysplasia (HP:0007033)1.09254174
139Retinal detachment (HP:0000541)1.08256340
140Pancreatic cysts (HP:0001737)1.06016909
141Aplasia/Hypoplasia of the tongue (HP:0010295)1.02248128
142Broad foot (HP:0001769)1.01712907
143Sclerocornea (HP:0000647)0.99105213
144Recurrent sinusitis (HP:0011108)0.99021617
145Aplasia/Hypoplasia of the macula (HP:0008059)0.98901255
146Specific learning disability (HP:0001328)0.98742650
147Decreased testicular size (HP:0008734)0.98251406
148Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.97704888
149Febrile seizures (HP:0002373)0.95370294
150Aplasia/Hypoplasia affecting the retina (HP:0008061)0.92975951
151Asthma (HP:0002099)0.92323853
152Visual hallucinations (HP:0002367)0.90674012
153Truncal ataxia (HP:0002078)0.89902866
154Chorioretinal coloboma (HP:0000567)0.87930550
155Hypermetropia (HP:0000540)0.85293943
156Progressive cerebellar ataxia (HP:0002073)0.85089606
157Prolonged QT interval (HP:0001657)0.83035118
158Furrowed tongue (HP:0000221)0.82195116
159Partial agenesis of the corpus callosum (HP:0001338)0.74273779
160Cholecystitis (HP:0001082)0.69712161
161Abnormal gallbladder physiology (HP:0012438)0.69712161
162Molar tooth sign on MRI (HP:0002419)0.68020462
163Abnormality of midbrain morphology (HP:0002418)0.68020462
164Hypodontia (HP:0000668)0.67004209
165Abnormality of dental color (HP:0011073)0.65976115
166Dental crowding (HP:0000678)0.65599153
167Postaxial hand polydactyly (HP:0001162)0.65275350
168Congenital hepatic fibrosis (HP:0002612)0.65022356
169Septo-optic dysplasia (HP:0100842)0.64606883
170Lymphopenia (HP:0001888)0.63684731
171Abnormality of the lower motor neuron (HP:0002366)0.62796245
172Anencephaly (HP:0002323)0.62623479
173Short foot (HP:0001773)0.62157865
174Hypoventilation (HP:0002791)0.61777449
175Syncope (HP:0001279)0.61284762
176Albinism (HP:0001022)0.60560661
177Abnormal EKG (HP:0003115)0.60341857
178Genetic anticipation (HP:0003743)0.59565888
179Hirsutism (HP:0001007)0.58770686
180Polycystic ovaries (HP:0000147)0.58520637
181Depression (HP:0000716)0.58223597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK19.77991911
2PBK7.74731876
3PINK13.08688881
4IRAK23.02484338
5NTRK33.00640757
6TESK22.94564770
7NTRK22.85900880
8UHMK12.42569081
9EPHA42.36062018
10MAP3K102.23848798
11NTRK12.05610020
12CAMK2B2.02915623
13TESK11.96558698
14INSRR1.92933042
15CAMK2G1.82369370
16MAP3K111.80901751
17TRIB31.71013707
18DAPK21.69687048
19NEK11.65454557
20CCNB11.64806736
21ERN11.63868387
22SIK21.60617958
23ICK1.58385168
24TYRO31.54099043
25ADRBK11.53209964
26CAMK1G1.52306999
27MAP2K31.52062639
28SGK4941.47088457
29SGK2231.47088457
30MAPK71.45728480
31ARAF1.40378214
32RPS6KA41.39079433
33CAMK1D1.38705911
34TAOK31.37126349
35PRKD31.32949740
36PAK61.28716009
37MAPK121.27234023
38MAP3K31.25686595
39HIPK21.24249476
40LIMK11.18243834
41DDR21.15740825
42TAOK21.15596153
43STK381.14010656
44CDK121.12970090
45MAP3K61.10815613
46BRD41.10494812
47PRKCZ1.06368006
48EPHB21.06272047
49PRKCH1.04024266
50MARK11.01862730
51PHKG20.99725064
52PHKG10.99725064
53CDK30.96396698
54ERBB20.95757134
55ROCK20.95617967
56CSNK1D0.93745924
57MAP3K130.89823317
58ABL20.89791438
59PRKAA10.88816580
60NME20.87332408
61MAP3K40.85524078
62SGK20.84541704
63LATS20.82599599
64NEK20.82266346
65CAMKK10.80161311
66LMTK20.79771829
67PNCK0.79366766
68DYRK1A0.79002198
69SGK30.78850015
70CDK150.77007831
71DAPK10.75557545
72CAMK2D0.74484713
73MARK20.74356020
74IRAK30.73895699
75SCYL20.73658656
76DYRK1B0.71480105
77CDK11A0.69883252
78CAMKK20.69211737
79KSR20.69082787
80CDK180.68987316
81PRKG20.68430020
82PRKACG0.67858927
83PTK20.66906943
84MOS0.66643495
85PDGFRA0.66282841
86CDK140.66127208
87SMG10.65793903
88PRKCB0.65531718
89AKT30.62789829
90WNK10.62469950
91GRK50.59883294
92RPS6KA30.59439935
93PRKD20.58112340
94DAPK30.57311056
95SIK10.56192334
96MYLK0.56155195
97ROCK10.55585904
98PRKAA20.55115895
99CAMK10.54128548
100BCKDK0.54095718
101DMPK0.53519357
102MAP3K70.52663134
103MAP3K10.50383686
104CAMK2A0.49532622
105CDK90.49342871
106FES0.48561396
107MINK10.47316621
108MAPK40.46972214
109MAPK90.46618085
110LATS10.46004554
111SGK10.45182241
112MAPKAPK50.44343231
113CAMK40.44164017
114PDPK10.43498600
115AKT20.43411068
116GSK3B0.42532836
117PIK3CA0.42239775
118PRKDC0.40876068
119RIPK10.40515810
120STK110.39735541
121MAPK140.39717996
122PRPF4B0.39151749
123FGFR20.38136342
124MAP2K10.37819891
125MAPK100.37768580
126CDK50.36975693
127MAP2K40.36273073
128PRKACA0.35956798
129RPS6KA50.35446071
130BMX0.35423240
131PLK20.35369598
132PRKCG0.34741438
133MAP3K90.34063425
134NEK60.32786537
135PDGFRB0.31969403
136PLK30.31063846
137PRKCA0.29470471
138CDK10.29060463
139CDC42BPA0.28445365
140PRKD10.28406498
141TTK0.25832068
142PKN10.25254438
143RPS6KB10.23552352
144CSNK1E0.22824884
145TNK20.22522517
146PAK30.21300398
147MAPK80.21048385
148ALK0.21006384
149WNK40.20665884
150CHEK20.19085554
151PDK20.18206756
152TTN0.17922226
153FGFR10.17791979
154MAPK30.17430560
155MTOR0.16164572

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa0474415.7781407
2Prion diseases_Homo sapiens_hsa050201.78426242
3Synaptic vesicle cycle_Homo sapiens_hsa047211.74711734
4Vibrio cholerae infection_Homo sapiens_hsa051101.66387328
5Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.51972110
6Olfactory transduction_Homo sapiens_hsa047401.51695523
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50191440
8Folate biosynthesis_Homo sapiens_hsa007901.40210900
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.35481086
10GABAergic synapse_Homo sapiens_hsa047271.32809696
11Sulfur relay system_Homo sapiens_hsa041221.28007352
12Arginine and proline metabolism_Homo sapiens_hsa003301.20793995
13Vitamin B6 metabolism_Homo sapiens_hsa007501.20715703
14Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14259717
15Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00320096
16Cholinergic synapse_Homo sapiens_hsa047250.94828962
17Circadian rhythm_Homo sapiens_hsa047100.94278851
18Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92499794
19Estrogen signaling pathway_Homo sapiens_hsa049150.92350703
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91262842
21Glioma_Homo sapiens_hsa052140.91006801
22Morphine addiction_Homo sapiens_hsa050320.90575485
23Retinol metabolism_Homo sapiens_hsa008300.89402045
24Circadian entrainment_Homo sapiens_hsa047130.86087677
25Melanogenesis_Homo sapiens_hsa049160.84177852
26VEGF signaling pathway_Homo sapiens_hsa043700.81730905
27Neurotrophin signaling pathway_Homo sapiens_hsa047220.81727812
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80625182
29Sphingolipid signaling pathway_Homo sapiens_hsa040710.80581229
30Other glycan degradation_Homo sapiens_hsa005110.80551030
31Dopaminergic synapse_Homo sapiens_hsa047280.80062596
32Glutamatergic synapse_Homo sapiens_hsa047240.77792289
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75022871
34Histidine metabolism_Homo sapiens_hsa003400.74807204
35Gap junction_Homo sapiens_hsa045400.71025918
36Lysosome_Homo sapiens_hsa041420.68703025
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68364167
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67362244
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67152903
40Insulin secretion_Homo sapiens_hsa049110.63314946
41Nitrogen metabolism_Homo sapiens_hsa009100.62181767
42Serotonergic synapse_Homo sapiens_hsa047260.61673356
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59273120
44ABC transporters_Homo sapiens_hsa020100.58896853
45Fatty acid biosynthesis_Homo sapiens_hsa000610.57526219
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56588665
47Rap1 signaling pathway_Homo sapiens_hsa040150.56441345
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52468163
49Nicotine addiction_Homo sapiens_hsa050330.50454231
50Fructose and mannose metabolism_Homo sapiens_hsa000510.49953749
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49939240
52Axon guidance_Homo sapiens_hsa043600.49909026
53Cardiac muscle contraction_Homo sapiens_hsa042600.47739448
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47012356
55Sphingolipid metabolism_Homo sapiens_hsa006000.46747435
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45385041
57ErbB signaling pathway_Homo sapiens_hsa040120.45118279
58Dilated cardiomyopathy_Homo sapiens_hsa054140.44334936
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44244968
60Oxytocin signaling pathway_Homo sapiens_hsa049210.43783518
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43523661
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41184141
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40812160
64Alzheimers disease_Homo sapiens_hsa050100.39697479
65Phagosome_Homo sapiens_hsa041450.39513769
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39042470
67mTOR signaling pathway_Homo sapiens_hsa041500.38874369
68ECM-receptor interaction_Homo sapiens_hsa045120.38110370
69Long-term depression_Homo sapiens_hsa047300.37706333
70PPAR signaling pathway_Homo sapiens_hsa033200.37005144
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36249950
72Purine metabolism_Homo sapiens_hsa002300.36249087
73Arginine biosynthesis_Homo sapiens_hsa002200.36236446
74Renin secretion_Homo sapiens_hsa049240.35664412
75cAMP signaling pathway_Homo sapiens_hsa040240.35662014
76Pertussis_Homo sapiens_hsa051330.35337974
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35083396
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34212546
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.34183826
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33462873
81Biosynthesis of amino acids_Homo sapiens_hsa012300.33273913
82Inositol phosphate metabolism_Homo sapiens_hsa005620.33131005
83Salivary secretion_Homo sapiens_hsa049700.33109141
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32315091
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31499826
86Type II diabetes mellitus_Homo sapiens_hsa049300.28560993
87Galactose metabolism_Homo sapiens_hsa000520.27275073
88Glucagon signaling pathway_Homo sapiens_hsa049220.26940906
89Fatty acid elongation_Homo sapiens_hsa000620.26462596
90Glycerolipid metabolism_Homo sapiens_hsa005610.26339708
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26322551
92Caffeine metabolism_Homo sapiens_hsa002320.26069604
93Gastric acid secretion_Homo sapiens_hsa049710.24507040
94Lysine degradation_Homo sapiens_hsa003100.24370373
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.23360486
96Alcoholism_Homo sapiens_hsa050340.23319206
97HIF-1 signaling pathway_Homo sapiens_hsa040660.22824696
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22778900
99AMPK signaling pathway_Homo sapiens_hsa041520.22001431
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.21285488
101Cocaine addiction_Homo sapiens_hsa050300.21062348
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21049478
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.20876338
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20769636
105Bile secretion_Homo sapiens_hsa049760.19150759
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18986615
107Chemokine signaling pathway_Homo sapiens_hsa040620.18284537
108Long-term potentiation_Homo sapiens_hsa047200.15043608
109Pancreatic secretion_Homo sapiens_hsa049720.13814773
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.13691837
111Carbon metabolism_Homo sapiens_hsa012000.12858560
112Calcium signaling pathway_Homo sapiens_hsa040200.12439484
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12122991
114Insulin resistance_Homo sapiens_hsa049310.12051990
115Amphetamine addiction_Homo sapiens_hsa050310.10937784
116Ras signaling pathway_Homo sapiens_hsa040140.09921906
117Pyruvate metabolism_Homo sapiens_hsa006200.09914715
118Collecting duct acid secretion_Homo sapiens_hsa049660.09854096
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.09151903
120Thyroid hormone synthesis_Homo sapiens_hsa049180.08591028
121Mineral absorption_Homo sapiens_hsa049780.08363141
122GnRH signaling pathway_Homo sapiens_hsa049120.08354467
123mRNA surveillance pathway_Homo sapiens_hsa030150.07546115
124Tight junction_Homo sapiens_hsa045300.07032478
125Fat digestion and absorption_Homo sapiens_hsa049750.06846143
126Taste transduction_Homo sapiens_hsa047420.06241452
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.06062974
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.05223072
129Fatty acid metabolism_Homo sapiens_hsa012120.05104823
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.04511488
131MAPK signaling pathway_Homo sapiens_hsa040100.04408646
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.03007075
133Linoleic acid metabolism_Homo sapiens_hsa005910.02664566
134Insulin signaling pathway_Homo sapiens_hsa049100.02437594
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.02253560
136Renal cell carcinoma_Homo sapiens_hsa052110.02055322
137Notch signaling pathway_Homo sapiens_hsa043300.01551834
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.01262921
139Endocytosis_Homo sapiens_hsa041440.01152791

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